Ligand: STU

Total number of chains: 108
Active chains: 28
Total number of genes: 39
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 64 59.3% 5E8XA
DFGin None 17 15.7% 6B1UA
DFGin ABAminus 9 8.3% 3LCSA
DFGin BLBplus 6 5.6% 7NVQA
DFGin BLBminus 4 3.7% 4EZ7A
None None 4 3.7% 3FMEA
DFGinter BABtrans 3 2.8% 2CLQA
DFGin BLAplus 1 0.9% 5LOHA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC MASTL GWL_HUMAN 5LOHA 3.1 Inactive DFGin‑BLAplus none-none out-out nonTYR APEdihe_aanon APEdist_nnno STU Type1 30 - 854 0 None None Serine/threonine-protein kinase greatwall
AGC MASTL GWL_HUMAN 5LOHB 3.1 Inactive None‑None none-none none-out nonTYR APEdihe_aannn APEdist_nnno STU Type1 30 - 854 0 None None Serine/threonine-protein kinase greatwall
AGC PDPK1 PDPK1_HUMAN 1OKYA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi STU Type1 72 - 360 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
AGC PRKCQ KPCT_HUMAN 1XJDA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 377 - 696 0 TPO538,SEP695 None Protein kinase C theta type
AGC RPS6KA1-1 KS6A1_HUMAN 2Z7RA 2.0 Inactive DFGin‑BLBplus none-none out-out nonTYR APEdihe_aaiii APEdist_nnno STU Type1 53 - 340 0 None None Ribosomal protein S6 kinase alpha-1
AGC RPS6KB1 KS6B1_HUMAN 3A62A 2.35 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aaioi APEdist_iioo STU Type1 85 - 372 0 TPO252 None Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A60A 2.8 Inactive DFGin‑None in-out out-none nonTYR APEdihe_aanii APEdist_nnnn STU Type1 85 - 371 0 None None Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A61A 3.43 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnno STU Type1 87 - 371 0 None None Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 4RLOB 2.527 Inactive None‑None none-none out-out nonTYR APEdihe_aanoi APEdist_nnnn STU Type1 85 - 372 0 None None Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A60B 2.8 Inactive None‑None none-none in-out nonTYR APEdihe_aaioi APEdist_nnoo STU Type1 85 - 372 0 None None Ribosomal protein S6 kinase beta-1
AGC STK32A ST32A_HUMAN 4FR4A 2.29 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 14 - 373 0 None None Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4B 2.29 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 14 - 373 0 None None Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4C 2.29 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 14 - 373 0 None None Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4D 2.29 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 14 - 373 0 None None Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4E 2.29 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 14 - 372 0 None None Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4F 2.29 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 14 - 373 0 None None Serine/threonine-protein kinase 32A
CAMK CHEK1 CHK1_HUMAN 1NVRA 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 3 - 273 0 None None Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7AKOA 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 2 - 271 0 None D10R Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7AKOB 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 2 - 271 0 None D10R Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5OORA 1.9 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 3 - 283 0 None N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S Serine/threonine-protein kinase Chk1
CAMK DAPK1 DAPK1_HUMAN 1WVYA 2.8 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi STU Type1 4 - 276 0 None None Death-associated protein kinase 1
CAMK MAPKAPK2 MAPK2_HUMAN 2PZYC 2.9 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn STU Type1 42 - 359 0 None None MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKA 2.7 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn STU Type1 42 - 345 0 None None MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKB 2.7 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn STU Type1 44 - 345 0 None None MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKC 2.7 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn STU Type1 41 - 357 0 None None MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKD 2.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaoio APEdist_nnoo STU Type1 43 - 342 0 None None MAP kinase-activated protein kinase 2
CAMK MKNK2 MKNK2_HUMAN 2HW7A 2.71 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno STU Type1 72 - 371 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2
CAMK PIM1 PIM1_HUMAN 1YHSA 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 33 - 305 0 SEP261 None Serine/threonine-protein kinase pim-1
CAMK PRKAA1 AAPK1_HUMAN 6C9FA 2.924 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii R34, STU Allosteric, Type1 22 - 558 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 6C9GA 2.7 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii R93, STU Allosteric, Type1 22 - 558 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 6C9HA 2.65 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii R34, STU Allosteric, Type1 22 - 558 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 6C9JA 3.05 Active DFGin‑BLAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii R34, STU Allosteric, Type1 22 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 4RERA 4.047 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 20 - 559 0 TPO183 E480G,E483A,K485A 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 4REWA 4.58 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaiii APEdist_iiio STU Type1 20 - 559 0 None E480G,E483A,K485A 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA2 AAPK2_HUMAN 5ISOA 2.63 Inactive DFGin‑ABAminus out-none in-out nonTYR APEdihe_aaioi APEdist_iiii STU, 992 Type1, Allosteric 9 - 551 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5ISOC 2.63 Inactive DFGin‑ABAminus out-none in-out nonTYR APEdihe_aaioi APEdist_iiii STU, 992 Type1, Allosteric 9 - 550 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 6B1UC 2.77 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii STU, CG7 Type1, Allosteric 9 - 552 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFFA 3.924 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioo APEdist_iiii STU Type1 8 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 8BIKA 2.5 Inactive DFGin‑BLAminus out-in in-out nonTYR APEdihe_aaioi APEdist_iiii STU, QTN Type1, Allosteric 8 - 551 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 8BIKD 2.5 Inactive DFGin‑BLAminus out-in in-out nonTYR APEdihe_aaioi APEdist_iiii STU, QTN Type1, Allosteric 9 - 551 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 6B2EA 3.8 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaioo APEdist_iiio STU, CG7 Type1, Allosteric 9 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFEA 3.023 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioo APEdist_iiii STU, 992 Type1, Allosteric 8 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFEC 3.023 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioo APEdist_iiii STU, 992 Type1, Allosteric 10 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5EZVA 2.99 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU, C1V Type1, Allosteric 8 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5EZVC 2.99 Inactive DFGin‑None out-in in-out nonTYR APEdihe_aaioi APEdist_iiii STU, C1V Type1, Allosteric 9 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 6B1UA 2.77 Inactive DFGin‑None out-in in-out nonTYR APEdihe_aaioi APEdist_iiii STU, CG7 Type1, Allosteric 8 - 550 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFFC 3.924 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaioo APEdist_iiii STU, C1V Type1, Allosteric 10 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2
CMGC CDK2 CDK2_HUMAN 4ERWA 2.0 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo STU Type1 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EZ7A 2.49 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaoii APEdist_oooo STU, 2AN, 2AN Type1, Type3, Allosteric 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1AQ1A 2.0 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaioi APEdist_nooo STU Type1 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7NVQA 2.05 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo STU Type1 1 - 294 0 None None Cyclin-dependent kinase 2
CMGC GSK3B GSK3B_HUMAN 1Q3DA 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 35 - 385 0 None None Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1Q3DB 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 35 - 383 0 None None Glycogen synthase kinase-3 beta
OTHER ERN1 ERN1_HUMAN 4YZCA 2.494 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 562 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZCB 2.494 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 562 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER STK16 STK16_HUMAN 2BUJA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU, STU Type1, Allosteric 13 - 299 0 None R19H,R266W Serine/threonine-protein kinase 16
OTHER STK16 STK16_HUMAN 2BUJB 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU, STU Type1, Type1 13 - 297 0 None R19H,R266W Serine/threonine-protein kinase 16
OTHER TTK TTK_HUMAN 3HMOA 2.4 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo STU Type1 514 - 794 0 None None Dual specificity protein kinase TTK
STE MAP2K6 MP2K6_HUMAN 3FMEA 2.26 Inactive None‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnno STU Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP3K5 M3K5_HUMAN 4BF2A 2.11 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaiii APEdist_iooi STU Type1 671 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 4BF2B 2.11 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_nnoi STU Type1 671 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 2CLQA 2.3 Inactive DFGinter‑BABtrans out-out in-out nonTYR APEdihe_aaiii APEdist_iooi STU Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 2CLQB 2.3 Inactive DFGinter‑BABtrans in-none in-out nonTYR APEdihe_aaiii APEdist_nooi STU Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE PAK4 PAK4_HUMAN 5VEDA 2.301 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE STK24 STK24_HUMAN 3CKXA 2.7 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 32 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QMYA 1.883 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 20 - 310 0 TPO190 None Serine/threonine-protein kinase 24
TKL IRAK4 IRAK4_HUMAN 2OICA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICB 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICC 2.4 None DFGin‑BLAminus in-in none-none nonTYR APEdihe_aaiii APEdist_nnni STU Type1 161 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICD 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRYC 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 164 - 458 0 TPO345 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRYD 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 164 - 460 0 TPO345 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U97A 2.65 None DFGin‑BLAminus in-in none-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 166 - 458 0 None D311N Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U9AA 2.8 None DFGin‑BLAminus in-in none-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 166 - 458 0 None D311N Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRYA 2.15 Inactive DFGin‑BLBminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 164 - 458 0 TPO345 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRYB 2.15 Inactive DFGin‑BLBminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 164 - 458 0 TPO345 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U97B 2.65 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno STU Type1 166 - 458 0 None D311N Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U9AB 2.8 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno STU Type1 166 - 458 0 None D311N Interleukin-1 receptor-associated kinase 4
TKL LIMK1 LIMK1_HUMAN 3S95A 1.65 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiai APEdist_iiii STU Type1 330 - 637 0 None None LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 3S95B 1.65 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiai APEdist_iiii STU Type1 330 - 637 0 None None LIM domain kinase 1
TKL RIPK2 RIPK2_HUMAN 5NG2A 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno STU Type1 5 - 298 0 None D146N Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5NG2B 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno STU Type1 5 - 298 0 None D146N Receptor-interacting serine/threonine-protein kinase 2
TKL TGFBR1 TGFR1_HUMAN 5E8XA 1.45 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 200 - 503 0 None T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 5E8WA 1.86 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 200 - 501 0 None T204D TGF-beta receptor type-1
TKL TGFBR2 TGFR2_HUMAN 5E8YA 2.05 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 240 - 541 0 None E431A,R433A,E485A,K488A,R493A,R495A TGF-beta receptor type-2
TYR ALK ALK_HUMAN 3LCSA 1.95 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao STU Type1 1096 - 1399 0 None S1281G ALK tyrosine kinase receptor
TYR CSK CSK_HUMAN 3D7TA 2.899 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 188 - 450 0 None K361A,K362A Tyrosine-protein kinase CSK
TYR CSK CSK_HUMAN 1BYGA 2.4 Inactive DFGinter‑BABtrans out-out none-none TYR APEdihe_nniai APEdist_aaai STU Type1 187 - 448 0 None None Tyrosine-protein kinase CSK
TYR EPHB4 EPHB4_HUMAN 3ZEWA 2.5 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai STU Type1 609 - 888 0 PTR774 None Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 3ZEWB 2.5 None DFGin‑BLAminus in-none none-none TYR APEdihe_nniai APEdist_aaai STU Type1 609 - 887 0 PTR774 None Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2YN8A 2.11 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 608 - 888 0 None Y774E,A803V,V870I Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2YN8B 2.11 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 606 - 888 0 None Y774E,A803V,V870I Ephrin type-B receptor 4
TYR FES FES_HUMAN 3BKBA 1.78 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai STU Type1 449 - 821 0 None None Tyrosine-protein kinase Fes/Fps
TYR FES FES_HUMAN 3CBLA 1.75 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU, STU, STU Type1, Allosteric, Allosteric 448 - 821 0 None None Tyrosine-protein kinase Fes/Fps
TYR FES FES_HUMAN 3CD3A 1.98 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU, STU, STU Type1, Allosteric, Allosteric 448 - 821 0 PTR713 None Tyrosine-protein kinase Fes/Fps
TYR FYN FYN_HUMAN 2DQ7X 2.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 261 - 523 0 PTR420 None Tyrosine-protein kinase Fyn
TYR ITK ITK_HUMAN 1SM2A 2.3 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SNUA 2.5 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SM2B 2.3 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 358 - 617 0 None None Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SNUB 2.5 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 358 - 617 0 None None Tyrosine-protein kinase ITK/TSK
TYR KIT KIT_HUMAN 8S19A 2.3 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 566 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 8S19B 2.3 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 566 - 930 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
TYR LCK LCK_HUMAN 1QPJA 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 236 - 501 0 PTR394 None Tyrosine-protein kinase Lck
TYR LCK LCK_HUMAN 1QPDA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck
TYR LYN LYN_HUMAN 3A4OX 3.0 Inactive DFGin‑None in-in in-out TYR APEdihe_ooiai APEdist_aaai STU Type1 238 - 505 0 None None Tyrosine-protein kinase Lyn
TYR NTRK1 NTRK1_HUMAN 9DAIA 2.864 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai STU Type1 501 - 796 0 None None High affinity nerve growth factor receptor
TYR SYK KSYK_HUMAN 1XBCA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
TYR ZAP70 ZAP70_HUMAN 1U59A 2.3 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao STU Type1 328 - 606 0 None None Tyrosine-protein kinase ZAP-70

Ligand: STU

Total number of chains: 131
Active chains: 31
Total number of genes: 47
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 71 54.2% 5E8XA
DFGin ABAminus 21 16.0% 4C34A
DFGin None 19 14.5% 6B1UA
DFGin BLBplus 6 4.6% 7NVQA
DFGin BLBminus 4 3.1% 4EZ7A
None None 4 3.1% 3FMEA
DFGinter BABtrans 3 2.3% 2CLQA
DFGout None 2 1.5% 3D7TB
DFGin BLAplus 1 0.8% 5LOHA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TKL CTR1 CTR1_ARATH 3PPZA 2.99 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 540 - 810 0 TPO704,SEP707,SEP710 None Serine/threonine-protein kinase CTR1 Arabidopsis thaliana
TKL CTR1 CTR1_ARATH 3P86A 2.496 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno STU Type1 544 - 810 0 None D676N Serine/threonine-protein kinase CTR1 Arabidopsis thaliana
AGC GRK2 ARBK1_BOVIN 8JPBG 3.07 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 2 - 659 0 None A292P,R295I,S455D Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 8JPCG 3.07 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 2 - 659 0 None A292P,R295I,S455D Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 8JPDG 2.81 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 2 - 659 0 None A292P,R295I,S455D Beta-adrenergic receptor kinase 1 Bos taurus
AGC PRKACA KAPCA_BOVIN 1STCE 2.3 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 16 - 351 0 SEP11,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_BOVIN 4C34A 1.78 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 11 - 351 0 SEP11,SEP140,TPO198,SEP339 F55Y,M121L,V124L,L174M,Q182K cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
TYR SRC SRC_CHICK 3D7TB 2.899 Inactive DFGout‑None in-in out-none TYR APEdihe_niiai APEdist_aaai STU Type1 258 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
AGC MASTL GWL_HUMAN 5LOHA 3.1 Inactive DFGin‑BLAplus none-none out-out nonTYR APEdihe_aanon APEdist_nnno STU Type1 30 - 854 0 None None Serine/threonine-protein kinase greatwall Homo sapiens
AGC MASTL GWL_HUMAN 5LOHB 3.1 Inactive None‑None none-none none-out nonTYR APEdihe_aannn APEdist_nnno STU Type1 30 - 854 0 None None Serine/threonine-protein kinase greatwall Homo sapiens
AGC PDPK1 PDPK1_HUMAN 1OKYA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi STU Type1 72 - 360 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PRKCQ KPCT_HUMAN 1XJDA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 377 - 696 0 TPO538,SEP695 None Protein kinase C theta type Homo sapiens
AGC RPS6KA1-1 KS6A1_HUMAN 2Z7RA 2.0 Inactive DFGin‑BLBplus none-none out-out nonTYR APEdihe_aaiii APEdist_nnno STU Type1 53 - 340 0 None None Ribosomal protein S6 kinase alpha-1 Homo sapiens
AGC RPS6KB1 KS6B1_HUMAN 3A62A 2.35 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aaioi APEdist_iioo STU Type1 85 - 372 0 TPO252 None Ribosomal protein S6 kinase beta-1 Homo sapiens
AGC RPS6KB1 KS6B1_HUMAN 3A60A 2.8 Inactive DFGin‑None in-out out-none nonTYR APEdihe_aanii APEdist_nnnn STU Type1 85 - 371 0 None None Ribosomal protein S6 kinase beta-1 Homo sapiens
AGC RPS6KB1 KS6B1_HUMAN 3A61A 3.43 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnno STU Type1 87 - 371 0 None None Ribosomal protein S6 kinase beta-1 Homo sapiens
AGC RPS6KB1 KS6B1_HUMAN 4RLOB 2.527 Inactive None‑None none-none out-out nonTYR APEdihe_aanoi APEdist_nnnn STU Type1 85 - 372 0 None None Ribosomal protein S6 kinase beta-1 Homo sapiens
AGC RPS6KB1 KS6B1_HUMAN 3A60B 2.8 Inactive None‑None none-none in-out nonTYR APEdihe_aaioi APEdist_nnoo STU Type1 85 - 372 0 None None Ribosomal protein S6 kinase beta-1 Homo sapiens
AGC STK32A ST32A_HUMAN 4FR4A 2.29 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 14 - 373 0 None None Serine/threonine-protein kinase 32A Homo sapiens
AGC STK32A ST32A_HUMAN 4FR4B 2.29 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 14 - 373 0 None None Serine/threonine-protein kinase 32A Homo sapiens
AGC STK32A ST32A_HUMAN 4FR4C 2.29 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 14 - 373 0 None None Serine/threonine-protein kinase 32A Homo sapiens
AGC STK32A ST32A_HUMAN 4FR4D 2.29 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 14 - 373 0 None None Serine/threonine-protein kinase 32A Homo sapiens
AGC STK32A ST32A_HUMAN 4FR4E 2.29 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 14 - 372 0 None None Serine/threonine-protein kinase 32A Homo sapiens
AGC STK32A ST32A_HUMAN 4FR4F 2.29 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 14 - 373 0 None None Serine/threonine-protein kinase 32A Homo sapiens
CAMK CHEK1 CHK1_HUMAN 1NVRA 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 3 - 273 0 None None Serine/threonine-protein kinase Chk1 Homo sapiens
CAMK CHEK1 CHK1_HUMAN 7AKOA 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 2 - 271 0 None D10R Serine/threonine-protein kinase Chk1 Homo sapiens
CAMK CHEK1 CHK1_HUMAN 7AKOB 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 2 - 271 0 None D10R Serine/threonine-protein kinase Chk1 Homo sapiens
CAMK CHEK1 CHK1_HUMAN 5OORA 1.9 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 3 - 283 0 None N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S Serine/threonine-protein kinase Chk1 Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 1WVYA 2.8 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi STU Type1 4 - 276 0 None None Death-associated protein kinase 1 Homo sapiens
CAMK MAPKAPK2 MAPK2_HUMAN 2PZYC 2.9 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn STU Type1 42 - 359 0 None None MAP kinase-activated protein kinase 2 Homo sapiens
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKA 2.7 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn STU Type1 42 - 345 0 None None MAP kinase-activated protein kinase 2 Homo sapiens
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKB 2.7 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn STU Type1 44 - 345 0 None None MAP kinase-activated protein kinase 2 Homo sapiens
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKC 2.7 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn STU Type1 41 - 357 0 None None MAP kinase-activated protein kinase 2 Homo sapiens
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKD 2.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaoio APEdist_nnoo STU Type1 43 - 342 0 None None MAP kinase-activated protein kinase 2 Homo sapiens
CAMK MKNK2 MKNK2_HUMAN 2HW7A 2.71 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno STU Type1 72 - 371 0 None D228G MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens
CAMK PIM1 PIM1_HUMAN 1YHSA 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 33 - 305 0 SEP261 None Serine/threonine-protein kinase pim-1 Homo sapiens
CAMK PRKAA1 AAPK1_HUMAN 6C9FA 2.924 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii R34, STU Allosteric, Type1 22 - 558 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
CAMK PRKAA1 AAPK1_HUMAN 6C9GA 2.7 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii R93, STU Allosteric, Type1 22 - 558 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
CAMK PRKAA1 AAPK1_HUMAN 6C9HA 2.65 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii R34, STU Allosteric, Type1 22 - 558 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
CAMK PRKAA1 AAPK1_HUMAN 6C9JA 3.05 Active DFGin‑BLAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii R34, STU Allosteric, Type1 22 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
CAMK PRKAA1 AAPK1_HUMAN 4RERA 4.047 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 20 - 559 0 TPO183 E480G,E483A,K485A 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
CAMK PRKAA1 AAPK1_HUMAN 4REWA 4.58 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaiii APEdist_iiio STU Type1 20 - 559 0 None E480G,E483A,K485A 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
CAMK PRKAA2 AAPK2_HUMAN 5ISOA 2.63 Inactive DFGin‑ABAminus out-none in-out nonTYR APEdihe_aaioi APEdist_iiii STU, 992 Type1, Allosteric 9 - 551 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens
CAMK PRKAA2 AAPK2_HUMAN 5ISOC 2.63 Inactive DFGin‑ABAminus out-none in-out nonTYR APEdihe_aaioi APEdist_iiii STU, 992 Type1, Allosteric 9 - 550 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens
CAMK PRKAA2 AAPK2_HUMAN 6B1UC 2.77 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii STU, CG7 Type1, Allosteric 9 - 552 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens
CAMK PRKAA2 AAPK2_HUMAN 4CFFA 3.924 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioo APEdist_iiii STU Type1 8 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens
CAMK PRKAA2 AAPK2_HUMAN 8BIKA 2.5 Inactive DFGin‑BLAminus out-in in-out nonTYR APEdihe_aaioi APEdist_iiii STU, QTN Type1, Allosteric 8 - 551 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens
CAMK PRKAA2 AAPK2_HUMAN 8BIKD 2.5 Inactive DFGin‑BLAminus out-in in-out nonTYR APEdihe_aaioi APEdist_iiii STU, QTN Type1, Allosteric 9 - 551 0 None None 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens
CAMK PRKAA2 AAPK2_HUMAN 6B2EA 3.8 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaioo APEdist_iiio STU, CG7 Type1, Allosteric 9 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens
CAMK PRKAA2 AAPK2_HUMAN 4CFEA 3.023 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioo APEdist_iiii STU, 992 Type1, Allosteric 8 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens
CAMK PRKAA2 AAPK2_HUMAN 4CFEC 3.023 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioo APEdist_iiii STU, 992 Type1, Allosteric 10 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens
CAMK PRKAA2 AAPK2_HUMAN 5EZVA 2.99 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU, C1V Type1, Allosteric 8 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens
CAMK PRKAA2 AAPK2_HUMAN 5EZVC 2.99 Inactive DFGin‑None out-in in-out nonTYR APEdihe_aaioi APEdist_iiii STU, C1V Type1, Allosteric 9 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens
CAMK PRKAA2 AAPK2_HUMAN 6B1UA 2.77 Inactive DFGin‑None out-in in-out nonTYR APEdihe_aaioi APEdist_iiii STU, CG7 Type1, Allosteric 8 - 550 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens
CAMK PRKAA2 AAPK2_HUMAN 4CFFC 3.924 Inactive DFGin‑None out-out in-out nonTYR APEdihe_aaioo APEdist_iiii STU, C1V Type1, Allosteric 10 - 551 0 TPO172 None 5'-AMP-activated protein kinase catalytic subunit alpha-2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 4ERWA 2.0 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo STU Type1 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 4EZ7A 2.49 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaoii APEdist_oooo STU, 2AN, 2AN Type1, Type3, Allosteric 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 1AQ1A 2.0 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaioi APEdist_nooo STU Type1 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 7NVQA 2.05 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo STU Type1 1 - 294 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC GSK3B GSK3B_HUMAN 1Q3DA 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 35 - 385 0 None None Glycogen synthase kinase-3 beta Homo sapiens
CMGC GSK3B GSK3B_HUMAN 1Q3DB 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 35 - 383 0 None None Glycogen synthase kinase-3 beta Homo sapiens
OTHER ERN1 ERN1_HUMAN 4YZCA 2.494 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 562 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
OTHER ERN1 ERN1_HUMAN 4YZCB 2.494 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 562 - 963 0 SEP724,SEP726,SEP729 None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
OTHER STK16 STK16_HUMAN 2BUJA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU, STU Type1, Allosteric 13 - 299 0 None R19H,R266W Serine/threonine-protein kinase 16 Homo sapiens
OTHER STK16 STK16_HUMAN 2BUJB 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU, STU Type1, Type1 13 - 297 0 None R19H,R266W Serine/threonine-protein kinase 16 Homo sapiens
OTHER TTK TTK_HUMAN 3HMOA 2.4 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo STU Type1 514 - 794 0 None None Dual specificity protein kinase TTK Homo sapiens
STE MAP2K6 MP2K6_HUMAN 3FMEA 2.26 Inactive None‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnno STU Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP3K5 M3K5_HUMAN 4BF2A 2.11 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaiii APEdist_iooi STU Type1 671 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 4BF2B 2.11 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_nnoi STU Type1 671 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 2CLQA 2.3 Inactive DFGinter‑BABtrans out-out in-out nonTYR APEdihe_aaiii APEdist_iooi STU Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 2CLQB 2.3 Inactive DFGinter‑BABtrans in-none in-out nonTYR APEdihe_aaiii APEdist_nooi STU Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE PAK4 PAK4_HUMAN 5VEDA 2.301 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE STK24 STK24_HUMAN 3CKXA 2.7 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 32 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK24 STK24_HUMAN 4QMYA 1.883 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 20 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 2OICA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 163 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 2OICB 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 2OICC 2.4 None DFGin‑BLAminus in-in none-none nonTYR APEdihe_aaiii APEdist_nnni STU Type1 161 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 2OICD 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 2NRYC 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 164 - 458 0 TPO345 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 2NRYD 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 164 - 460 0 TPO345 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 4U97A 2.65 None DFGin‑BLAminus in-in none-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 166 - 458 0 None D311N Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 4U9AA 2.8 None DFGin‑BLAminus in-in none-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 166 - 458 0 None D311N Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 2NRYA 2.15 Inactive DFGin‑BLBminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 164 - 458 0 TPO345 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 2NRYB 2.15 Inactive DFGin‑BLBminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 164 - 458 0 TPO345 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 4U97B 2.65 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno STU Type1 166 - 458 0 None D311N Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 4U9AB 2.8 Inactive DFGin‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno STU Type1 166 - 458 0 None D311N Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL LIMK1 LIMK1_HUMAN 3S95A 1.65 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiai APEdist_iiii STU Type1 330 - 637 0 None None LIM domain kinase 1 Homo sapiens
TKL LIMK1 LIMK1_HUMAN 3S95B 1.65 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiai APEdist_iiii STU Type1 330 - 637 0 None None LIM domain kinase 1 Homo sapiens
TKL RIPK2 RIPK2_HUMAN 5NG2A 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno STU Type1 5 - 298 0 None D146N Receptor-interacting serine/threonine-protein kinase 2 Homo sapiens
TKL RIPK2 RIPK2_HUMAN 5NG2B 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno STU Type1 5 - 298 0 None D146N Receptor-interacting serine/threonine-protein kinase 2 Homo sapiens
TKL TGFBR1 TGFR1_HUMAN 5E8XA 1.45 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 200 - 503 0 None T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F TGF-beta receptor type-1 Homo sapiens
TKL TGFBR1 TGFR1_HUMAN 5E8WA 1.86 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 200 - 501 0 None T204D TGF-beta receptor type-1 Homo sapiens
TKL TGFBR2 TGFR2_HUMAN 5E8YA 2.05 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 240 - 541 0 None E431A,R433A,E485A,K488A,R493A,R495A TGF-beta receptor type-2 Homo sapiens
TYR ALK ALK_HUMAN 3LCSA 1.95 Inactive DFGin‑ABAminus in-in out-out TYR APEdihe_oiiai APEdist_aaao STU Type1 1096 - 1399 0 None S1281G ALK tyrosine kinase receptor Homo sapiens
TYR CSK CSK_HUMAN 3D7TA 2.899 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 188 - 450 0 None K361A,K362A Tyrosine-protein kinase CSK Homo sapiens
TYR CSK CSK_HUMAN 1BYGA 2.4 Inactive DFGinter‑BABtrans out-out none-none TYR APEdihe_nniai APEdist_aaai STU Type1 187 - 448 0 None None Tyrosine-protein kinase CSK Homo sapiens
TYR EPHB4 EPHB4_HUMAN 3ZEWA 2.5 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai STU Type1 609 - 888 0 PTR774 None Ephrin type-B receptor 4 Homo sapiens
TYR EPHB4 EPHB4_HUMAN 3ZEWB 2.5 None DFGin‑BLAminus in-none none-none TYR APEdihe_nniai APEdist_aaai STU Type1 609 - 887 0 PTR774 None Ephrin type-B receptor 4 Homo sapiens
TYR EPHB4 EPHB4_HUMAN 2YN8A 2.11 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 608 - 888 0 None Y774E,A803V,V870I Ephrin type-B receptor 4 Homo sapiens
TYR EPHB4 EPHB4_HUMAN 2YN8B 2.11 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 606 - 888 0 None Y774E,A803V,V870I Ephrin type-B receptor 4 Homo sapiens
TYR FES FES_HUMAN 3BKBA 1.78 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai STU Type1 449 - 821 0 None None Tyrosine-protein kinase Fes/Fps Homo sapiens
TYR FES FES_HUMAN 3CBLA 1.75 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU, STU, STU Type1, Allosteric, Allosteric 448 - 821 0 None None Tyrosine-protein kinase Fes/Fps Homo sapiens
TYR FES FES_HUMAN 3CD3A 1.98 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU, STU, STU Type1, Allosteric, Allosteric 448 - 821 0 PTR713 None Tyrosine-protein kinase Fes/Fps Homo sapiens
TYR FYN FYN_HUMAN 2DQ7X 2.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 261 - 523 0 PTR420 None Tyrosine-protein kinase Fyn Homo sapiens
TYR ITK ITK_HUMAN 1SM2A 2.3 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
TYR ITK ITK_HUMAN 1SNUA 2.5 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
TYR ITK ITK_HUMAN 1SM2B 2.3 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 358 - 617 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
TYR ITK ITK_HUMAN 1SNUB 2.5 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 358 - 617 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
TYR KIT KIT_HUMAN 8S19A 2.3 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 566 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
TYR KIT KIT_HUMAN 8S19B 2.3 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 566 - 930 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
TYR LCK LCK_HUMAN 1QPJA 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 236 - 501 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
TYR LCK LCK_HUMAN 1QPDA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
TYR LYN LYN_HUMAN 3A4OX 3.0 Inactive DFGin‑None in-in in-out TYR APEdihe_ooiai APEdist_aaai STU Type1 238 - 505 0 None None Tyrosine-protein kinase Lyn Homo sapiens
TYR NTRK1 NTRK1_HUMAN 9DAIA 2.864 Inactive DFGin‑None in-in none-none TYR APEdihe_nniai APEdist_aaai STU Type1 501 - 796 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR SYK KSYK_HUMAN 1XBCA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
TYR ZAP70 ZAP70_HUMAN 1U59A 2.3 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao STU Type1 328 - 606 0 None None Tyrosine-protein kinase ZAP-70 Homo sapiens
TYR RTKC8 A9VBW0_MONBE 8E4TA 1.95 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaao STU, STU Type1, Allosteric 1412 - 1684 0 None None non-specific protein-tyrosine kinase Monosiga brevicollis
CAMK PRKAA1 AAPK1_MOUSE 5UFUA 3.45 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, 85V Type1, Allosteric 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Mus musculus
TKL RIPK4 RIPK4_MOUSE 5WNLA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_nnoo STU Type1 10 - 288 0 None D143N Receptor-interacting serine/threonine-protein kinase 4 Mus musculus
CAMK CDPK2 CDPK2_PLAFK 4MVFA 2.0 Inactive DFGin‑ABAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn STU Type1 60 - 511 0 None None Calcium-dependent protein kinase 2 Plasmodium falciparum
CAMK PRKAA1 AAPK1_RAT 6E4TA 3.4 Inactive DFGin‑ABAminus out-in in-out nonTYR APEdihe_aaioi APEdist_iiio HTV, STU Allosteric, Type1 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
CAMK PRKAA1 AAPK1_RAT 4QFGA 3.46 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
CAMK PRKAA1 AAPK1_RAT 4QFRA 3.34 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, 32J Type1, Allosteric 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
CAMK PRKAA1 AAPK1_RAT 4QFSA 3.55 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, 32H Type1, Allosteric 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
CAMK PRKAA1 AAPK1_RAT 6E4UA 3.27 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, HU7 Type1, Allosteric 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
CAMK PRKAA1 AAPK1_RAT 6E4WA 3.35 Inactive DFGin‑ABAminus out-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, HUG Type1, Allosteric 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
CAMK PRKAA1 AAPK1_RAT 5T5TA 3.46 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU Type1 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
CAMK PRKAA1 AAPK1_RAT 4CFHA 3.24 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiio APEdist_iiio STU Type1 21 - 481 0 TPO183,TPO388 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
CAMK PRKAA1 AAPK1_RAT 5KQ5A 3.41 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, 6VT Type1, Allosteric 21 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
STE TAOK2 TAOK2_RAT 2GCDA 2.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 12 - 320 0 SEP181 None Serine/threonine-protein kinase TAO2 Rattus norvegicus
STE TAOK2 TAOK2_RAT 2GCDB 2.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 12 - 320 0 SEP181 None Serine/threonine-protein kinase TAO2 Rattus norvegicus

Ligand: STU

Total number of chains: 23
Active chains: 3
Total number of genes: 9
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 12 52.2% 4C34A
DFGin BLAminus 7 30.4% 2GCDA
DFGin None 2 8.7% 4CFHA
DFGout None 2 8.7% 3D7TB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TKL CTR1 CTR1_ARATH 3PPZA 2.99 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 540 - 810 0 TPO704,SEP707,SEP710 None Serine/threonine-protein kinase CTR1 Arabidopsis thaliana
TKL CTR1 CTR1_ARATH 3P86A 2.496 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno STU Type1 544 - 810 0 None D676N Serine/threonine-protein kinase CTR1 Arabidopsis thaliana
AGC GRK2 ARBK1_BOVIN 8JPBG 3.07 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 2 - 659 0 None A292P,R295I,S455D Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 8JPCG 3.07 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 2 - 659 0 None A292P,R295I,S455D Beta-adrenergic receptor kinase 1 Bos taurus
AGC GRK2 ARBK1_BOVIN 8JPDG 2.81 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 2 - 659 0 None A292P,R295I,S455D Beta-adrenergic receptor kinase 1 Bos taurus
AGC PRKACA KAPCA_BOVIN 1STCE 2.3 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 16 - 351 0 SEP11,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_BOVIN 4C34A 1.78 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 11 - 351 0 SEP11,SEP140,TPO198,SEP339 F55Y,M121L,V124L,L174M,Q182K cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
TYR SRC SRC_CHICK 3D7TB 2.899 Inactive DFGout‑None in-in out-none TYR APEdihe_niiai APEdist_aaai STU Type1 258 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR RTKC8 A9VBW0_MONBE 8E4TA 1.95 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaao STU, STU Type1, Allosteric 1412 - 1684 0 None None non-specific protein-tyrosine kinase Monosiga brevicollis
CAMK PRKAA1 AAPK1_MOUSE 5UFUA 3.45 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, 85V Type1, Allosteric 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Mus musculus
TKL RIPK4 RIPK4_MOUSE 5WNLA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_nnoo STU Type1 10 - 288 0 None D143N Receptor-interacting serine/threonine-protein kinase 4 Mus musculus
CAMK CDPK2 CDPK2_PLAFK 4MVFA 2.0 Inactive DFGin‑ABAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn STU Type1 60 - 511 0 None None Calcium-dependent protein kinase 2 Plasmodium falciparum
CAMK PRKAA1 AAPK1_RAT 6E4TA 3.4 Inactive DFGin‑ABAminus out-in in-out nonTYR APEdihe_aaioi APEdist_iiio HTV, STU Allosteric, Type1 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
CAMK PRKAA1 AAPK1_RAT 4QFGA 3.46 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
CAMK PRKAA1 AAPK1_RAT 4QFRA 3.34 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, 32J Type1, Allosteric 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
CAMK PRKAA1 AAPK1_RAT 4QFSA 3.55 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, 32H Type1, Allosteric 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
CAMK PRKAA1 AAPK1_RAT 6E4UA 3.27 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, HU7 Type1, Allosteric 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
CAMK PRKAA1 AAPK1_RAT 6E4WA 3.35 Inactive DFGin‑ABAminus out-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, HUG Type1, Allosteric 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
CAMK PRKAA1 AAPK1_RAT 5T5TA 3.46 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU Type1 20 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
CAMK PRKAA1 AAPK1_RAT 4CFHA 3.24 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiio APEdist_iiio STU Type1 21 - 481 0 TPO183,TPO388 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
CAMK PRKAA1 AAPK1_RAT 5KQ5A 3.41 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_iiio STU, 6VT Type1, Allosteric 21 - 559 0 TPO183 None 5'-AMP-activated protein kinase catalytic subunit alpha-1 Rattus norvegicus
STE TAOK2 TAOK2_RAT 2GCDA 2.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 12 - 320 0 SEP181 None Serine/threonine-protein kinase TAO2 Rattus norvegicus
STE TAOK2 TAOK2_RAT 2GCDB 2.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 12 - 320 0 SEP181 None Serine/threonine-protein kinase TAO2 Rattus norvegicus