AGC_MASTL (Serine/threonine-protein kinase greatwall)

Total number of chains: 5
Active chains: 2
Uniprot: GWL_HUMAN
Kinase Domain Residues: 35 - 835
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 60.0% AF-Q96GX5-K1A
DFGin BLAplus 1 20.0% 5LOHA
None None 1 20.0% 5LOHB

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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q96GX5-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 27 - 843 0 None None Serine/threonine-protein kinase greatwall
AF-Q96GX5-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 27 - 843 0 None None Serine/threonine-protein kinase greatwall
8V5HA 2.74 Inactive DFGin‑BLAminus in-out none-out nonTYR APEdihe_aaiii APEdist_nnoo A1AAE Type1 29 - 847 0 None None Serine/threonine-protein kinase greatwall
5LOHA 3.1 Inactive DFGin‑BLAplus none-none out-out nonTYR APEdihe_aanon APEdist_nnno STU Type1 30 - 854 0 None None Serine/threonine-protein kinase greatwall
5LOHB 3.1 Inactive None‑None none-none none-out nonTYR APEdihe_aannn APEdist_nnno STU Type1 30 - 854 0 None None Serine/threonine-protein kinase greatwall

AGC_MASTL (Serine/threonine-protein kinase greatwall)

Total number of chains: 5
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 60.0% AF-Q96GX5-K1A
DFGin BLAplus 1 20.0% 5LOHA
None None 1 20.0% 5LOHB

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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
GWL_HUMAN AF-Q96GX5-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 27 - 843 0 None None Serine/threonine-protein kinase greatwall Homo sapiens
GWL_HUMAN AF-Q96GX5-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 27 - 843 0 None None Serine/threonine-protein kinase greatwall Homo sapiens
GWL_HUMAN 8V5HA 2.74 Inactive DFGin‑BLAminus in-out none-out nonTYR APEdihe_aaiii APEdist_nnoo A1AAE Type1 29 - 847 0 None None Serine/threonine-protein kinase greatwall Homo sapiens
GWL_HUMAN 5LOHA 3.1 Inactive DFGin‑BLAplus none-none out-out nonTYR APEdihe_aanon APEdist_nnno STU Type1 30 - 854 0 None None Serine/threonine-protein kinase greatwall Homo sapiens
GWL_HUMAN 5LOHB 3.1 Inactive None‑None none-none none-out nonTYR APEdihe_aannn APEdist_nnno STU Type1 30 - 854 0 None None Serine/threonine-protein kinase greatwall Homo sapiens

AGC_MASTL (Serine/threonine-protein kinase greatwall)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism