Ligand: STU

Total number of chains: 108
Active chains: 28
Total number of genes: 39
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 64 59.3% 5E8XA
DFGin None 17 15.7% 6B1UA
DFGin ABAminus 9 8.3% 3LCSA
DFGin BLBplus 6 5.6% 7NVQA
DFGin BLBminus 4 3.7% 4EZ7A
None None 4 3.7% 3FMEA
DFGinter BABtrans 3 2.8% 2CLQA
DFGin BLAplus 1 0.9% 5LOHA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC MASTL GWL_HUMAN 5LOHA Q96GX5 30 854 879.0 STU:60901 Type1 Inactive DFGin 10.8403 13.5188 BLAplus -154.04, -179.93 62.84, 37.43 -106.51, -23.39 59.72, 80.58 -168.74, -25.48 none-none none 999.0 Saltbr-none 999.0 HRD-in -59.31, -45.76 66.7, 4.42 none-out-out SNCnoo out-out ActLoopNT-out 8.33 ActLoopCT-out nonTYR APEdihe_aanon APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 165.16 APE8-dihe-none -79.14, 999.0 APE8-rot-out 44.79 APE67-dihe-none -72.42, -27.62 999.0, 33.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8912 None None None XRAY 3.1 0.209 0.265 A 341.0 246.0 34 28 13 15 [[35, 835]] 1.0 5loh AGC_MASTL_HUMAN AGC 4e-131 441.8 1.0 260.0 260.0 173 174 175 177 179 62 81 85 153 155 154 156.0 760 201 196 195 741 740 -9999 -9999 -9999 111 Serine/threonine-protein kinase greatwall
AGC MASTL GWL_HUMAN 5LOHB Q96GX5 30 854 879.0 STU:60901 Type1 Inactive None 999.0 13.3388 None -152.85, -174.25 66.27, 69.27 -150.61, -21.46 41.33, 82.81 -90.34, 22.29 none-none none 999.0 Saltbr-none 999.0 HRD-in -60.11, -44.59 64.53, 4.15 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aannn APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -141.8 APE8-dihe-none -77.31, 999.0 APE8-rot-none 999.0 APE67-dihe-none 49.84, -65.93 999.0, -82.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7129 None None None XRAY 3.1 0.209 0.265 B 341.0 250.0 30 28 11 17 [[35, 835]] 1.0 5loh AGC_MASTL_HUMAN AGC 4e-131 441.8 1.0 260.0 260.0 173 174 175 177 179 62 81 85 153 155 154 156.0 760 201 196 195 741 740 -9999 -9999 -9999 111 Serine/threonine-protein kinase greatwall
AGC PDPK1 PDPK1_HUMAN 1OKYA O15530 72 360 556.0 STU:1368 Type1 Inactive DFGin 6.1532 14.4616 BLAminus -148.97, -170.84 70.56, 80.45 -102.75, 23.82 286.84, 96.04 -69.28, -20.21 in-in in 8.6718 Saltbr-in 2.6729 HRD-in -67.69, -57.78 80.28, 0.43 in-in-out SNCiio in-out ActLoopNT-in 2.9341 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.7, -80.59 APE9-dihe-na 115.49, 169.91 APE8-dihe-in -54.49, 123.73 APE8-rot-in 316.76 APE67-dihe-in -63.35, -17.55 -42.07, -50.54 APE12-dist-in 9.2892 APE11-dist-out 5.5558 APE10-dist-out 9.7186 APE9-dist-in 4.222 None SEP241 SEP241 XRAY 2.3 0.219 0.255 A 310.0 283.0 6 30 24 6 [[82, 342]] 1.0 1oky AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PRKCQ KPCT_HUMAN 1XJDA Q04759 377 696 706.0 STU:200 Type1 Active DFGin 5.8284 13.1925 BLAminus -132.69, 162.8 69.28, 95.13 -109.8, 21.13 305.67, 104.94 -64.79, -17.76 in-in in 8.0639 Saltbr-in 2.5131 HRD-in -67.27, -48.59 64.56, -1.72 in-in-in SNCiii in-in ActLoopNT-in 2.9684 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.73, 166.78 APE9-dihe-na 120.3, 163.8 APE8-dihe-in -75.86, 125.98 APE8-rot-in 298.87 APE67-dihe-in -57.15, -29.94 -38.43, -48.34 APE12-dist-in 9.0296 APE11-dist-in 12.2938 APE10-dist-in 6.8961 APE9-dist-in 3.7669 None TPO538,SEP695 TPO538,SEP695 XRAY 2.0 0.201 0.216 A 345.0 282.0 0 28 28 0 [[380, 634]] 1.0 1xjd AGC_PRKCQ_HUMAN AGC 1.2e-95 325.5 1.0 260.0 260.0 521 522 523 525 527 409 428 432 501 503 502 504.0 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC RPS6KA1-1 KS6A1_HUMAN 2Z7RA Q15418 53 340 735.0 STU:1 Type1 Inactive DFGin 6.9283 12.3219 BLBplus -135.18, 169.76 58.7, 61.01 -129.8, -169.31 56.27, 83.01 123.62, -72.1 none-none none 999.0 Saltbr-none 999.0 HRD-out -70.75, 75.42 -55.39, -34.53 none-out-out SNCnoo out-out ActLoopNT-out 7.3785 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.4 APE8-dihe-in -65.4, 109.6 APE8-rot-in 309.27 APE67-dihe-in -55.68, -21.45 -56.7, -41.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.7538 None None None XRAY 2.0 0.255 0.286 A 321.0 265.0 23 28 16 12 [[62, 321], [418, 675]] 2.0 2z7r AGC_RPS6KA1-1_HUMAN AGC 1.5e-95 325.1 1.0 260.0 260.0 204 205 206 208 210 94 112 116 184 186 185 187.0 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
AGC RPS6KB1 KS6B1_HUMAN 3A62A P23443 85 372 525.0 STU:400 Type1 Inactive DFGin 6.524 14.1168 ABAminus -137.83, -32.54 -98.98, 101.69 -111.0, 24.18 305.63, 93.27 -75.95, -178.42 in-in in 8.2379 Saltbr-in 2.9117 HRD-in -88.81, -24.52 69.43, -47.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -65.23, -49.64 APE9-dihe-na -102.67, -164.37 APE8-dihe-in -63.46, 142.22 APE8-rot-out 175.82 APE67-dihe-in -68.79, -14.76 -111.61, 8.72 APE12-dist-in 10.2473 APE11-dist-in 13.1357 APE10-dist-out 9.3091 APE9-dist-out 11.6078 None TPO252 TPO252 XRAY 2.35 0.229 0.272 A 327.0 264.0 24 28 18 10 [[91, 352]] 1.0 3a62 AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1.0 260.0 260.0 235 236 237 239 241 123 143 147 215 217 216 218.0 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A60A P23443 85 371 525.0 STU:400 Type1 Inactive DFGin 6.1574 13.694 None -106.91, -67.93 -78.35, 124.27 -119.68, -133.11 293.51, 79.75 162.78, -54.12 in-out in 7.7541 Saltbr-out 3.9045 HRD-in -63.83, -43.18 73.78, -30.83 out-out-none SNCoon out-none ActLoopNT-out 3.673 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -74.9 APE8-rot-in 297.46 APE67-dihe-in -54.54, -22.69 -86.47, -11.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.21 0.268 A 327.0 263.0 24 28 15 13 [[91, 352]] 1.0 3a60 AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1.0 260.0 260.0 235 236 237 239 241 123 143 147 215 217 216 218.0 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A61A P23443 87 371 525.0 STU:400 Type1 Inactive DFGin 5.8125 13.4055 None -134.05, -75.4 -81.48, 111.28 -98.21, -179.91 302.65, 80.45 -119.91, 999.0 in-in in 7.8631 Saltbr-in 3.4595 HRD-in -91.01, -26.19 64.38, -56.51 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -70.31 APE8-dihe-in -167.04, 106.84 APE8-rot-out 166.31 APE67-dihe-in -54.66, 20.97 -86.85, -22.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9635 None None None XRAY 3.43 0.274 0.349 A 327.0 254.0 31 28 12 16 [[91, 352]] 1.0 3a61 AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1.0 260.0 260.0 235 236 237 239 241 123 143 147 215 217 216 218.0 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 4RLOB P23443 85 372 525.0 STU:401 Type1 Inactive None 999.0 7.1958 None -86.75, 160.35 -107.62, 22.98 -156.62, 162.78 69.29, 88.54 159.5, 162.01 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.31, -49.02 69.03, -42.5 none-out-out SNCnoo out-out ActLoopNT-out 4.8155 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 152.17 APE8-rot-out 189.44 APE67-dihe-in -65.44, -8.07 -124.54, 4.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.527 0.193 0.222 B 288.0 254.0 34 28 17 11 [[91, 352]] 1.0 4rlo AGC_RPS6KB1_HUMAN AGC 2.9e-96 327.5 1.0 260.0 260.0 235 236 237 239 241 123 143 147 215 217 216 218.0 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A60B P23443 85 372 525.0 STU:401 Type1 Inactive None 999.0 9.1812 None -122.3, -155.7 -144.9, 63.43 -46.62, 179.79 231.81, 121.03 -99.91, 37.09 none-none none 999.0 Saltbr-none 999.0 HRD-in -85.46, -48.18 73.35, -54.05 none-in-out SNCnio in-out ActLoopNT-in 2.8646 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -2.69 APE9-dihe-na -82.95, -88.68 APE8-dihe-in -146.72, 128.75 APE8-rot-out 80.81 APE67-dihe-in -72.02, 1.17 -100.99, 0.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 29.7774 APE9-dist-out 31.9666 None None None XRAY 2.8 0.21 0.268 B 327.0 255.0 33 28 18 10 [[91, 352]] 1.0 3a60 AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1.0 260.0 260.0 235 236 237 239 241 123 143 147 215 217 216 218.0 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC STK32A ST32A_HUMAN 4FR4A Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 6.9576 14.5496 BLAminus -131.26, -171.36 55.81, 77.24 -91.39, 23.54 282.26, 68.76 -52.72, -37.5 in-out in 9.4495 Saltbr-out 4.4048 HRD-in -80.59, -48.19 75.72, 1.95 out-in-in SNCoii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.54, 125.66 APE9-dihe-na 163.36, -179.6 APE8-dihe-in -98.31, 118.28 APE8-rot-in 302.74 APE67-dihe-in -69.16, -7.09 -58.36, -42.03 APE12-dist-in 9.9839 APE11-dist-in 11.6999 APE10-dist-in 6.0373 APE9-dist-in 3.5766 None None None XRAY 2.29 0.206 0.244 A 384.0 350.0 0 27 27 0 [[23, 281]] 1.0 4fr4 AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1.0 259.0 259.0 163 164 165 167 169 52 71 75 143 145 144 146.0 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4B Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 7.0038 14.6646 BLAminus -130.94, -173.3 57.57, 78.46 -91.73, 35.47 281.68, 71.64 -62.72, -37.53 in-out in 9.5233 Saltbr-out 4.6779 HRD-in -83.22, -47.99 75.33, -2.43 out-in-in SNCoii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.47, 130.4 APE9-dihe-na 159.4, 177.51 APE8-dihe-in -93.68, 119.81 APE8-rot-in 304.76 APE67-dihe-in -71.88, -7.25 -60.98, -38.06 APE12-dist-in 10.0245 APE11-dist-in 11.735 APE10-dist-in 6.0193 APE9-dist-in 3.5697 None None None XRAY 2.29 0.206 0.244 B 384.0 350.0 0 27 27 0 [[23, 281]] 1.0 4fr4 AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1.0 259.0 259.0 163 164 165 167 169 52 71 75 143 145 144 146.0 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4C Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 6.9501 14.6971 BLAminus -132.52, -169.93 52.69, 78.95 -90.58, 33.35 282.07, 69.09 -66.67, -30.48 in-out in 9.5382 Saltbr-out 4.6525 HRD-in -81.16, -46.81 73.79, 0.59 out-in-in SNCoii in-in ActLoopNT-in 2.9022 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.08, 126.04 APE9-dihe-na 163.32, 177.32 APE8-dihe-in -92.37, 117.65 APE8-rot-in 306.61 APE67-dihe-in -71.09, -9.62 -57.49, -40.3 APE12-dist-in 9.9861 APE11-dist-in 11.7192 APE10-dist-in 6.0306 APE9-dist-in 3.5686 None None None XRAY 2.29 0.206 0.244 C 384.0 344.0 0 27 27 0 [[23, 281]] 1.0 4fr4 AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1.0 259.0 259.0 163 164 165 167 169 52 71 75 143 145 144 146.0 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4D Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 6.9681 14.5401 BLAminus -131.99, -171.7 54.78, 77.72 -90.01, 30.97 282.82, 68.36 -59.09, -35.1 in-out in 9.5397 Saltbr-out 4.1113 HRD-in -82.23, -46.79 74.71, 0.05 out-in-in SNCoii in-in ActLoopNT-in 2.9038 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.67, 126.06 APE9-dihe-na 163.38, 179.82 APE8-dihe-in -95.08, 119.14 APE8-rot-in 303.5 APE67-dihe-in -68.68, -8.82 -58.5, -42.47 APE12-dist-in 10.0285 APE11-dist-in 11.6738 APE10-dist-in 5.9782 APE9-dist-in 3.621 None None None XRAY 2.29 0.206 0.244 D 384.0 346.0 0 27 27 0 [[23, 281]] 1.0 4fr4 AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1.0 259.0 259.0 163 164 165 167 169 52 71 75 143 145 144 146.0 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4E Q8WU08 14 372 396.0 STU:401 Type1 Inactive DFGin 6.9286 14.6895 BLAminus -131.82, -175.27 57.96, 79.76 -93.48, 35.37 282.42, 66.15 -67.02, -30.68 in-out in 9.5587 Saltbr-out 4.6665 HRD-in -80.84, -48.94 74.6, -0.56 out-in-in SNCoii in-in ActLoopNT-in 2.9355 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.84, 126.86 APE9-dihe-na 161.76, 179.6 APE8-dihe-in -94.71, 118.0 APE8-rot-in 302.52 APE67-dihe-in -65.82, -9.98 -56.35, -43.97 APE12-dist-in 10.0325 APE11-dist-in 11.7534 APE10-dist-in 6.0105 APE9-dist-in 3.5549 None None None XRAY 2.29 0.206 0.244 E 384.0 342.0 0 27 27 0 [[23, 281]] 1.0 4fr4 AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1.0 259.0 259.0 163 164 165 167 169 52 71 75 143 145 144 146.0 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4F Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 6.9223 14.4801 BLAminus -133.24, -172.46 54.73, 79.35 -94.14, 35.98 283.65, 67.48 -61.74, -33.87 in-out in 9.4582 Saltbr-out 4.4586 HRD-in -80.63, -46.14 70.35, 4.86 out-in-in SNCoii in-in ActLoopNT-in 2.8837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.84, 129.22 APE9-dihe-na 160.43, 179.28 APE8-dihe-in -96.01, 118.11 APE8-rot-in 307.21 APE67-dihe-in -68.52, -8.52 -57.81, -41.21 APE12-dist-in 10.0068 APE11-dist-in 11.7034 APE10-dist-in 5.9864 APE9-dist-in 3.5873 None None None XRAY 2.29 0.206 0.244 F 384.0 346.0 0 27 27 0 [[23, 281]] 1.0 4fr4 AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1.0 259.0 259.0 163 164 165 167 169 52 71 75 143 145 144 146.0 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
CAMK CHEK1 CHK1_HUMAN 1NVRA O14757 3 273 476.0 STU:400 Type1 Active DFGin 7.0073 14.466 BLAminus -138.12, 170.91 63.58, 88.44 -97.82, 26.51 284.37, 82.9 -65.94, -21.37 in-in in 8.8343 Saltbr-in 3.3246 HRD-in -77.73, -42.26 72.42, 0.07 in-in-in SNCiii in-in ActLoopNT-in 2.8923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.96, 168.99 APE9-dihe-na 123.47, -148.6 APE8-dihe-in -135.84, 118.76 APE8-rot-in 301.9 APE67-dihe-in -60.54, -22.99 -38.52, -52.15 APE12-dist-in 8.9865 APE11-dist-in 11.7725 APE10-dist-in 6.2204 APE9-dist-in 3.3435 None None None XRAY 1.8 0.193 0.226 A 289.0 264.0 7 30 30 0 [[9, 265]] 1.0 1nvr CAMK_CHEK1_HUMAN CAMK 2.6e-71 245.9 2.0 256.0 255.0 147 148 149 151 153 38 55 59 127 129 128 130.0 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7AKOA O14757 2 271 476.0 STU:60301 Type1 Active DFGin 7.2577 14.3463 BLAminus -129.99, 164.38 63.12, 90.57 -95.99, 30.1 286.66, 77.28 -66.31, -26.96 in-in in 8.8335 Saltbr-in 2.687 HRD-in -79.3, -45.9 76.54, 2.66 in-in-in SNCiii in-in ActLoopNT-in 2.9991 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.15, 172.04 APE9-dihe-na 107.34, -156.22 APE8-dihe-in -136.58, 123.75 APE8-rot-in 305.71 APE67-dihe-in -59.04, -20.83 -49.6, -50.22 APE12-dist-in 8.9513 APE11-dist-in 11.9214 APE10-dist-in 6.385 APE9-dist-in 3.5724 D10R None None XRAY 1.8 0.192 0.235 A 300.0 270.0 0 30 30 0 [[9, 265]] 1.0 7ako CAMK_CHEK1_HUMAN CAMK 3.4e-71 245.5 2.0 256.0 255.0 147 148 149 151 153 38 55 59 127 129 128 130.0 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7AKOB O14757 2 271 476.0 STU:60301 Type1 Active DFGin 7.0372 14.5267 BLAminus -133.06, 166.86 60.65, 91.44 -101.1, 26.21 287.91, 78.35 -62.72, -24.94 in-in in 9.1831 Saltbr-in 3.4036 HRD-in -77.35, -44.25 76.09, 6.63 in-in-in SNCiii in-in ActLoopNT-in 3.0391 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.79, 168.24 APE9-dihe-na 123.14, -149.89 APE8-dihe-in -132.89, 126.1 APE8-rot-in 304.27 APE67-dihe-in -62.82, -10.87 -52.63, -48.98 APE12-dist-in 8.6304 APE11-dist-in 11.8841 APE10-dist-in 6.2467 APE9-dist-in 3.4952 D10R None None XRAY 1.8 0.192 0.235 B 300.0 270.0 0 30 30 0 [[9, 265]] 1.0 7ako CAMK_CHEK1_HUMAN CAMK 3.4e-71 245.5 2.0 256.0 255.0 147 148 149 151 153 38 55 59 127 129 128 130.0 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5OORA O14757 3 283 476.0 STU:301 Type1 Inactive DFGin 7.1962 13.6031 BLAminus -121.08, 157.07 78.53, 94.76 -101.65, 21.08 291.71, 78.34 -70.5, -20.28 in-out in 9.325 Saltbr-out 5.3808 HRD-in -78.63, -43.76 73.29, -4.94 out-in-in SNCoii in-in ActLoopNT-in 2.9061 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.81, 173.83 APE9-dihe-na 115.52, -146.73 APE8-dihe-in -140.31, 116.76 APE8-rot-in 299.43 APE67-dihe-in -68.59, -17.99 -48.27, -41.97 APE12-dist-in 9.1544 APE11-dist-in 11.7443 APE10-dist-in 6.2959 APE9-dist-in 3.5968 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.9 0.167 0.208 A 297.0 273.0 8 30 30 0 [[9, 265]] 1.0 5oor CAMK_CHEK1_HUMAN CAMK 4.8e-69 238.4 2.0 256.0 255.0 147 148 149 151 153 38 55 59 127 129 128 130.0 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK DAPK1 DAPK1_HUMAN 1WVYA P53355 4 276 1430.0 STU:1001 Type1 Inactive DFGin 6.7415 14.2933 ABAminus -89.35, -23.12 -108.72, 148.84 -138.39, 21.2 279.12, 93.85 -56.2, -46.66 in-in in 9.4531 Saltbr-in 2.7914 HRD-in -70.14, -42.49 63.36, 7.4 in-in-out SNCiio in-out ActLoopNT-in 2.7569 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -134.32, 148.67 APE9-dihe-na -105.19, -133.62 APE8-dihe-in -62.12, 122.93 APE8-rot-in 303.72 APE67-dihe-in -56.52, -27.75 -50.01, -41.98 APE12-dist-in 10.3491 APE11-dist-out 5.638 APE10-dist-out 8.7625 APE9-dist-in 4.9739 None None None XRAY 2.8 0.222 0.274 A 278.0 273.0 0 27 27 0 [[13, 275]] 1.0 1wvy CAMK_DAPK1_HUMAN CAMK 5e-95 323.6 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK MAPKAPK2 MAPK2_HUMAN 2PZYC P49137 42 359 400.0 STU:3 Type1 None DFGin 4.7421 13.5838 BLAminus -137.32, 155.33 89.76, 83.85 -93.67, 22.39 287.9, 52.26 -71.67, 3.21 in-in in 8.8993 Saltbr-in 2.4787 HRD-in -82.26, -44.82 71.63, -15.61 in-in-none SNCiin in-none ActLoopNT-in 2.8228 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -81.01, -7.47 999.0, -140.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.251 0.313 C 324.0 307.0 11 27 16 11 [[63, 325]] 1.0 2pzy CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3.0 256.0 254.0 206 207 208 210 212 93 104 108 183 185 184 186.0 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKA P49137 42 345 400.0 STU:401 Type1 None DFGin 4.8289 13.4276 BLAminus -122.05, -170.73 42.15, 101.84 -103.58, 19.28 282.18, 65.24 -58.03, -23.15 in-in in 8.7159 Saltbr-in 2.4725 HRD-in -79.4, -39.47 62.13, 0.83 in-in-none SNCiin in-none ActLoopNT-in 2.6831 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -71.16, 3.04 999.0, 148.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 A 400.0 290.0 14 27 16 11 [[63, 325]] 1.0 1nxk CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3.0 256.0 254.0 206 207 208 210 212 93 104 108 183 185 184 186.0 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKB P49137 44 345 400.0 STU:403 Type1 None DFGin 4.5769 13.8216 BLAminus -128.27, 177.79 53.09, 103.0 -104.87, 20.3 276.49, 67.38 -57.0, -14.43 in-in in 8.6474 Saltbr-in 2.5635 HRD-in -64.22, -46.2 66.47, 1.25 in-in-none SNCiin in-none ActLoopNT-in 2.8195 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.0, -19.87 999.0, 111.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 B 400.0 283.0 19 27 16 11 [[63, 325]] 1.0 1nxk CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3.0 256.0 254.0 206 207 208 210 212 93 104 108 183 185 184 186.0 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKC P49137 41 357 400.0 STU:401 Type1 None DFGin 4.9628 13.774 BLAminus -132.89, 178.15 57.47, 93.76 -100.34, 25.49 283.43, 65.32 -70.88, 11.4 in-in in 8.6843 Saltbr-in 2.3398 HRD-in -75.36, -47.72 65.17, 8.17 in-in-none SNCiin in-none ActLoopNT-in 2.9819 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.28, 2.34 999.0, 115.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 C 400.0 306.0 11 27 16 11 [[63, 325]] 1.0 1nxk CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3.0 256.0 254.0 206 207 208 210 212 93 104 108 183 185 184 186.0 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKD P49137 43 342 400.0 STU:401 Type1 Inactive DFGin 4.8314 13.91 BLAminus -136.01, 172.45 58.97, 96.18 -97.02, 30.62 280.59, 64.96 -55.97, -37.81 in-in in 8.8025 Saltbr-in 2.6493 HRD-in -61.55, -54.52 76.31, -8.43 in-in-out SNCiio in-out ActLoopNT-in 3.0037 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, 21.79 APE9-dihe-na -95.93, -89.71 APE8-dihe-out 87.4, 89.72 APE8-rot-in 304.66 APE67-dihe-out -57.06, -12.13 -63.98, 136.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 30.4871 APE9-dist-out 33.3307 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 D 400.0 288.0 12 27 19 8 [[63, 325]] 1.0 1nxk CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3.0 256.0 254.0 206 207 208 210 212 93 104 108 183 185 184 186.0 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MKNK2 MKNK2_HUMAN 2HW7A Q9HBH9 72 371 465.0 STU:60031 Type1 Inactive DFGin 4.9051 14.1234 BLBplus -153.19, 172.78 68.05, 27.15 -77.7, 175.81 23.89, 67.82 81.52, 999.0 in-in in 8.9926 Saltbr-in 2.9032 HRD-in -73.6, -55.95 77.37, -18.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 26.54 APE8-dihe-out -84.42, -14.4 APE8-rot-in 301.04 APE67-dihe-in -61.16, -21.76 -49.65, -47.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 33.4696 D228G None None XRAY 2.71 0.203 0.246 A 316.0 269.0 31 35 12 23 [[83, 368]] 1.0 2hw7 CAMK_MKNK2_HUMAN CAMK 8e-79 270.5 1.0 256.0 256.0 225 226 227 229 231 113 129 133 202 204 203 205.0 277 260 255 254 253 252 251 250 249 160 MAP kinase-interacting serine/threonine-protein kinase 2
CAMK PIM1 PIM1_HUMAN 1YHSA P11309 33 305 313.0 STU:306 Type1 Active DFGin 6.3607 14.5116 BLAminus -129.35, 165.16 65.09, 87.92 -99.2, 21.71 283.47, 69.45 -67.38, -11.76 in-in in 8.5242 Saltbr-in 2.8992 HRD-naA -65.05, -49.56 68.79, 3.6 in-in-in SNCiii in-in ActLoopNT-in 2.9031 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.4, 26.1 APE9-dihe-na -84.03, -156.82 APE8-dihe-in -85.78, 122.63 APE8-rot-in 304.34 APE67-dihe-in -62.69, -6.01 -56.85, -49.38 APE12-dist-in 9.327 APE11-dist-in 8.5203 APE10-dist-in 5.5084 APE9-dist-in 3.8321 None SEP261 CME161,SEP261 XRAY 2.15 0.233 0.233 A 273.0 269.0 4 26 26 0 [[38, 290]] 1.0 1yhs CAMK_PIM1_HUMAN CAMK 2.4e-65 226.3 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PRKAA1 AAPK1_HUMAN 6C9FA Q13131 22 558 559.0 R34:60601,STU:60602 Allosteric,Type1 Inactive DFGin 6.7283 14.2948 ABAminus -116.49, -61.55 -94.26, 110.71 -99.52, 6.4 287.66, 85.72 -50.13, -39.13 out-out out 10.7128 Saltbr-out 5.3185 HRD-in -66.33, -58.11 53.99, 16.31 out-in-out SNCoio in-out ActLoopNT-in 2.7714 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.89, 155.28 APE9-dihe-na 94.11, 171.31 APE8-dihe-in -69.7, 144.51 APE8-rot-out 175.9 APE67-dihe-in -64.59, -37.19 -54.17, -35.84 APE12-dist-in 8.2675 APE11-dist-in 10.7302 APE10-dist-in 5.1485 APE9-dist-in 4.2372 None TPO183 TPO183 XRAY 2.924 0.229 0.245 A 494.0 371.0 0 27 27 0 [[27, 279]] 1.0 6c9f CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 6C9GA Q13131 22 558 559.0 R93:60601,STU:60602 Allosteric,Type1 Inactive DFGin 6.9066 14.3995 BLAminus -135.02, 170.21 60.34, 77.63 -85.45, 11.43 285.05, 75.57 -50.8, -32.37 out-out out 10.6954 Saltbr-out 5.5967 HRD-in -79.11, -48.44 68.49, -16.14 out-in-out SNCoio in-out ActLoopNT-in 2.8772 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -145.15, 158.83 APE9-dihe-na 72.57, 174.42 APE8-dihe-in -69.04, 143.86 APE8-rot-out 162.73 APE67-dihe-in -62.81, -32.14 -55.18, -38.62 APE12-dist-in 8.4498 APE11-dist-in 11.0313 APE10-dist-in 6.0082 APE9-dist-in 4.0093 None TPO183 TPO183 XRAY 2.7 0.205 0.24 A 494.0 384.0 0 27 27 0 [[27, 279]] 1.0 6c9g CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 6C9HA Q13131 22 558 559.0 R34:60601,STU:60602 Allosteric,Type1 Inactive DFGin 6.7117 14.3818 BLAminus -138.26, 171.2 60.5, 73.75 -84.01, 6.76 285.61, 85.73 -48.49, -36.53 out-out out 10.6488 Saltbr-out 5.6307 HRD-in -69.22, -48.97 68.92, -5.29 out-in-out SNCoio in-out ActLoopNT-in 3.017 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -142.6, 158.62 APE9-dihe-na 60.32, -132.0 APE8-dihe-in -130.57, 153.41 APE8-rot-out 177.79 APE67-dihe-in -63.0, -34.49 -63.07, -41.05 APE12-dist-in 8.6555 APE11-dist-in 10.6184 APE10-dist-in 6.1892 APE9-dist-in 3.8729 None None None XRAY 2.65 0.215 0.242 A 494.0 433.0 0 27 27 0 [[27, 279]] 1.0 6c9h CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 6C9JA Q13131 22 559 559.0 R34:60601,STU:60602 Allosteric,Type1 Active DFGin 6.9799 13.9321 BLAminus -148.31, -179.86 61.68, 68.06 -82.96, 8.26 285.07, 89.54 -49.65, -37.12 out-in out 10.0503 Saltbr-in 3.0249 HRD-in -61.18, -61.45 68.18, -7.34 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.03, 155.55 APE9-dihe-na 81.79, 170.06 APE8-dihe-in -65.93, 140.22 APE8-rot-in 298.24 APE67-dihe-in -65.83, -31.14 -52.06, -38.38 APE12-dist-in 8.3121 APE11-dist-in 11.1991 APE10-dist-in 5.6399 APE9-dist-in 4.1005 None TPO183 TPO183 XRAY 3.05 0.215 0.225 A 494.0 384.0 0 27 27 0 [[27, 279]] 1.0 6c9j CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 4RERA Q13131 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.7243 14.6822 None -104.41, -74.44 -70.58, 123.21 -111.45, 7.12 271.34, 95.59 -64.34, -25.66 in-in in 9.3938 Saltbr-in 3.1678 HRD-out -106.73, 104.09 -76.93, -37.65 in-in-in SNCiii in-in ActLoopNT-in 2.9275 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.23, 162.43 APE9-dihe-na 109.76, -176.61 APE8-dihe-in -65.38, 159.16 APE8-rot-in 282.67 APE67-dihe-in -82.84, -28.7 -67.98, -40.26 APE12-dist-in 8.7645 APE11-dist-in 11.1018 APE10-dist-in 5.3529 APE9-dist-in 4.5655 E480G,E483A,K485A TPO183 TPO183 XRAY 4.047 0.227 0.26 A 540.0 459.0 0 27 27 0 [[27, 279]] 1.0 4rer CAMK_PRKAA1_HUMAN CAMK 8.5e-89 303.4 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 4REWA Q13131 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.2816 14.4447 None -106.98, -78.3 -79.98, 116.66 -98.66, 4.74 266.69, 106.69 -52.57, -49.44 out-out out 10.8944 Saltbr-out 4.8489 HRD-out -91.4, 104.28 -79.59, -35.51 out-in-out SNCoio in-out ActLoopNT-in 2.9485 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -146.3, 177.71 APE9-dihe-na 92.22, 179.97 APE8-dihe-in -62.77, 176.84 APE8-rot-in 309.53 APE67-dihe-in -79.73, -37.36 -85.43, -26.86 APE12-dist-in 9.0318 APE11-dist-in 10.9116 APE10-dist-in 6.0735 APE9-dist-out 7.1663 E480G,E483A,K485A None None XRAY 4.58 0.234 0.259 A 540.0 411.0 0 27 27 0 [[27, 279]] 1.0 4rew CAMK_PRKAA1_HUMAN CAMK 8.5e-89 303.4 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA2 AAPK2_HUMAN 5ISOA P54646 9 551 552.0 STU:601,992:602 Type1,Allosteric Inactive DFGin 7.0764 13.7542 ABAminus -124.01, -69.61 -91.71, 113.8 -98.34, 8.3 284.02, 83.8 -52.09, -32.8 out-none out 10.6758 Saltbr-none 999.0 HRD-in -77.82, -48.64 73.79, -15.56 none-in-out SNCnio in-out ActLoopNT-in 3.0698 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -153.96, 161.46 APE9-dihe-na 108.89, 175.81 APE8-dihe-in -73.92, 127.97 APE8-rot-out 47.66 APE67-dihe-in -62.08, -29.52 -54.52, -36.25 APE12-dist-in 8.114 APE11-dist-in 11.3548 APE10-dist-in 6.5955 APE9-dist-in 5.0387 None None None XRAY 2.63 0.18 0.23 A 552.0 453.0 0 27 27 0 [[16, 268]] 1.0 5iso CAMK_PRKAA2_HUMAN CAMK 1.1e-89 306.3 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5ISOC P54646 9 550 552.0 STU:601,992:602 Type1,Allosteric Inactive DFGin 7.1851 14.12 ABAminus -118.95, -64.95 -97.93, 114.29 -100.77, 6.08 282.8, 83.31 -57.51, -20.09 out-none out 10.9206 Saltbr-none 999.0 HRD-in -73.97, -50.71 73.94, -15.38 none-in-out SNCnio in-out ActLoopNT-in 3.0258 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.17, 145.11 APE9-dihe-na 105.06, -178.93 APE8-dihe-in -75.45, 134.7 APE8-rot-out 182.56 APE67-dihe-in -57.91, -29.21 -54.57, -40.7 APE12-dist-in 9.0148 APE11-dist-in 11.2229 APE10-dist-in 5.4236 APE9-dist-in 4.3015 None None None XRAY 2.63 0.18 0.23 C 552.0 429.0 0 27 27 0 [[16, 268]] 1.0 5iso CAMK_PRKAA2_HUMAN CAMK 1.1e-89 306.3 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 6B1UC P54646 9 552 552.0 STU:60601,CG7:60602 Type1,Allosteric Inactive DFGin 7.4516 14.1299 ABAminus -133.95, -50.46 -79.36, 100.93 -96.81, 22.67 283.51, 87.03 -67.96, -35.6 out-out out 10.2466 Saltbr-out 4.344 HRD-in -62.69, -52.12 64.78, 6.12 out-in-out SNCoio in-out ActLoopNT-in 3.0313 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 59.85, -130.04 APE9-dihe-na -84.76, -170.01 APE8-dihe-in -60.51, 139.79 APE8-rot-out 157.81 APE67-dihe-in -64.49, -24.93 -66.94, -29.94 APE12-dist-in 7.802 APE11-dist-in 10.1021 APE10-dist-in 6.0757 APE9-dist-in 4.4225 None TPO172 TPO172 XRAY 2.77 0.196 0.226 C 565.0 460.0 0 27 27 0 [[16, 268]] 1.0 6b1u CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFFA P54646 8 551 552.0 STU:61552 Type1 Inactive DFGin 7.0564 14.0818 BLAminus -149.77, 179.95 57.3, 81.92 -95.29, 37.99 289.6, 92.87 -75.43, -19.2 out-out out 10.9893 Saltbr-out 5.616 HRD-out -79.02, 102.38 -90.23, 5.49 out-in-out SNCoio in-out ActLoopNT-in 3.1062 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -140.4, 154.3 APE9-dihe-na 120.73, -179.28 APE8-dihe-in -68.72, 155.02 APE8-rot-out 179.49 APE67-dihe-out -92.39, 175.4 -57.6, -33.75 APE12-dist-in 7.9516 APE11-dist-in 11.1768 APE10-dist-in 5.5536 APE9-dist-in 3.902 None TPO172 TPO172 XRAY 3.924 0.211 0.264 A 571.0 425.0 0 27 27 0 [[16, 268]] 1.0 4cff CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 8BIKA P54646 8 551 552.0 STU:61001,QTN:61002 Type1,Allosteric Inactive DFGin 7.4108 14.1375 BLAminus -139.87, 175.04 60.92, 88.41 -94.92, 18.04 278.75, 87.35 -59.01, -34.32 out-in out 10.1739 Saltbr-in 2.8766 HRD-in -67.48, -51.05 72.2, -5.59 in-in-out SNCiio in-out ActLoopNT-in 3.0285 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.52, 150.63 APE9-dihe-na 107.16, 178.8 APE8-dihe-in -62.54, 134.22 APE8-rot-out 175.32 APE67-dihe-in -59.81, -28.17 -63.52, -36.76 APE12-dist-in 7.7788 APE11-dist-in 11.4392 APE10-dist-in 5.7681 APE9-dist-in 4.246 None None None XRAY 2.5 0.183 0.215 A 559.0 451.0 0 27 27 0 [[16, 268]] 1.0 8bik CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 8BIKD P54646 9 551 552.0 STU:61001,QTN:61002 Type1,Allosteric Inactive DFGin 7.384 14.4446 BLAminus -141.24, 172.63 63.28, 83.56 -89.35, 21.67 278.42, 85.15 -58.54, -35.7 out-in out 10.1752 Saltbr-in 2.8052 HRD-in -67.72, -52.05 72.56, -5.24 in-in-out SNCiio in-out ActLoopNT-in 3.0392 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -138.07, 151.38 APE9-dihe-na 109.6, 178.13 APE8-dihe-in -63.22, 133.31 APE8-rot-out 174.24 APE67-dihe-in -63.88, -27.23 -63.0, -33.55 APE12-dist-in 7.8083 APE11-dist-in 11.3382 APE10-dist-in 5.6939 APE9-dist-in 4.2241 None None None XRAY 2.5 0.183 0.215 D 559.0 443.0 0 27 27 0 [[16, 268]] 1.0 8bik CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 6B2EA P54646 9 551 552.0 STU:60601,CG7:60602 Type1,Allosteric Inactive DFGin 6.8359 14.6749 BLAminus -127.75, -179.24 60.25, 73.12 -88.18, 14.06 273.69, 88.23 -67.6, -15.67 out-none out 10.0019 Saltbr-none 999.0 HRD-out -78.51, 91.55 -68.49, -19.81 none-in-out SNCnio in-out ActLoopNT-in 3.1235 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiio APE10-dihe-na -70.16, 148.6 APE9-dihe-na -63.35, -41.66 APE8-dihe-in -61.85, 118.31 APE8-rot-out 58.89 APE67-dihe-out -81.11, 165.06 -67.04, -35.27 APE12-dist-in 8.4672 APE11-dist-in 10.8 APE10-dist-in 6.9386 APE9-dist-out 8.497 None TPO172 TPO172 XRAY 3.8 0.246 0.277 A 565.0 443.0 0 27 27 0 [[16, 268]] 1.0 6b2e CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFEA P54646 8 551 552.0 STU:61552,992:61553 Type1,Allosteric Inactive DFGin 7.0796 14.0721 BLAminus -145.68, 179.18 60.7, 83.63 -96.97, 26.73 284.08, 87.71 -65.51, -24.73 out-out out 10.7276 Saltbr-out 5.3537 HRD-out -86.27, 102.77 -89.89, 0.95 out-in-out SNCoio in-out ActLoopNT-in 3.1121 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -129.79, 163.12 APE9-dihe-na 115.46, -178.56 APE8-dihe-in -67.55, 156.43 APE8-rot-out 179.35 APE67-dihe-out -75.24, 179.33 -55.61, -52.75 APE12-dist-in 7.8317 APE11-dist-in 11.1822 APE10-dist-in 5.5022 APE9-dist-in 4.035 None TPO172 TPO172 XRAY 3.023 0.219 0.253 A 571.0 426.0 0 27 27 0 [[16, 268]] 1.0 4cfe CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFEC P54646 10 551 552.0 STU:61552,992:61553 Type1,Allosteric Inactive DFGin 6.7879 14.041 BLAminus -149.49, 177.86 54.08, 78.43 -74.33, -60.5 283.52, 75.88 44.88, -65.29 out-out out 10.8275 Saltbr-out 5.2457 HRD-out -83.19, 107.96 -92.05, 0.22 out-in-out SNCoio in-out ActLoopNT-in 2.9738 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -138.71, 159.05 APE9-dihe-na 117.28, 177.67 APE8-dihe-in -66.82, 154.33 APE8-rot-out 184.3 APE67-dihe-out -85.99, 172.12 -55.69, -41.12 APE12-dist-in 7.7099 APE11-dist-in 11.0432 APE10-dist-in 5.4181 APE9-dist-in 4.2153 None TPO172 TPO172 XRAY 3.023 0.219 0.253 C 571.0 404.0 0 27 27 0 [[16, 268]] 1.0 4cfe CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5EZVA P54646 8 551 552.0 STU:60601,C1V:60602 Type1,Allosteric Inactive DFGin 7.2674 14.6333 None -121.03, -63.06 -68.65, 101.9 -100.19, 25.35 279.34, 91.81 -68.17, -44.69 in-in in 9.8608 Saltbr-in 2.6899 HRD-in -59.46, -47.11 63.8, -4.14 in-in-in SNCiii in-in ActLoopNT-in 3.0028 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.63, 144.51 APE9-dihe-na 86.66, 177.12 APE8-dihe-in -64.88, 140.75 APE8-rot-in 312.82 APE67-dihe-in -66.61, -22.38 -58.4, -32.39 APE12-dist-in 7.7539 APE11-dist-in 10.4368 APE10-dist-in 5.1306 APE9-dist-in 4.4026 None TPO172 TPO172 XRAY 2.99 0.225 0.245 A 560.0 433.0 0 27 27 0 [[16, 268]] 1.0 5ezv CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5EZVC P54646 9 551 552.0 STU:60601,C1V:60602 Type1,Allosteric Inactive DFGin 7.4323 14.3494 None -121.9, -67.2 -69.32, 103.91 -104.03, 30.29 280.2, 90.51 -70.5, -44.85 out-in out 10.4146 Saltbr-in 3.2079 HRD-in -65.9, -50.28 64.78, -4.1 in-in-out SNCiio in-out ActLoopNT-in 2.9393 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.83, 151.12 APE9-dihe-na 88.46, 177.26 APE8-dihe-in -64.21, 140.09 APE8-rot-out 194.68 APE67-dihe-in -65.12, -32.21 -57.93, -31.87 APE12-dist-in 7.8362 APE11-dist-in 10.5358 APE10-dist-in 5.1127 APE9-dist-in 4.4856 None TPO172 TPO172 XRAY 2.99 0.225 0.245 C 560.0 434.0 0 27 27 0 [[16, 268]] 1.0 5ezv CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 6B1UA P54646 8 550 552.0 STU:60601,CG7:60602 Type1,Allosteric Inactive DFGin 7.2691 14.4408 None -129.47, -55.38 -79.75, 100.47 -94.16, 25.18 281.88, 87.91 -69.36, -38.1 out-in out 10.0903 Saltbr-in 2.8061 HRD-in -70.7, -48.35 62.09, 8.12 in-in-out SNCiio in-out ActLoopNT-in 3.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -119.71, 141.45 APE9-dihe-na 98.59, 173.56 APE8-dihe-in -72.38, 142.58 APE8-rot-out 181.03 APE67-dihe-in -62.9, -27.33 -58.67, -32.16 APE12-dist-in 7.9718 APE11-dist-in 10.5218 APE10-dist-in 4.9765 APE9-dist-in 3.8757 None TPO172 TPO172 XRAY 2.77 0.196 0.226 A 565.0 442.0 0 27 27 0 [[16, 268]] 1.0 6b1u CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFFC P54646 10 551 552.0 STU:61552,C1V:61553 Type1,Allosteric Inactive DFGin 6.7813 14.0798 None -150.62, -172.52 53.67, 68.27 -65.24, -76.3 281.99, 78.69 54.48, -69.27 out-out out 10.8955 Saltbr-out 5.3095 HRD-out -84.81, 105.73 -92.0, 12.06 out-in-out SNCoio in-out ActLoopNT-in 3.0342 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -122.19, 170.3 APE9-dihe-na 112.32, 178.27 APE8-dihe-in -67.95, 156.54 APE8-rot-out 180.36 APE67-dihe-out -82.42, 177.62 -55.27, -42.84 APE12-dist-in 7.7542 APE11-dist-in 11.1374 APE10-dist-in 5.4326 APE9-dist-in 3.967 None TPO172 TPO172 XRAY 3.924 0.211 0.264 C 571.0 423.0 0 27 27 0 [[16, 268]] 1.0 4cff CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CMGC CDK2 CDK2_HUMAN 4ERWA P24941 1 298 298.0 STU:301 Type1 Inactive DFGin 8.1617 15.6021 BLBminus -125.29, 160.66 52.47, 61.82 -60.63, 138.56 279.12, 65.63 -74.82, 135.35 out-out out 15.4669 Saltbr-out 12.0237 HRD-in -85.09, -48.23 77.57, -22.2 out-out-out SNCooo out-out ActLoopNT-out 9.2791 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -82.87, 148.53 APE9-dihe-na -96.15, 140.05 APE8-dihe-in -88.42, 131.99 APE8-rot-out 198.97 APE67-dihe-in -59.72, -24.59 -102.21, -6.98 APE12-dist-out 19.529 APE11-dist-out 16.2582 APE10-dist-out 18.6866 APE9-dist-out 10.8972 None None OCS177 XRAY 2.0 0.196 0.244 A 306.0 293.0 5 28 28 0 [[4, 286]] 1.0 4erw CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EZ7A P24941 1 298 298.0 STU:60301,2AN:60302,2AN:60303 Type1,Type3,Allosteric Inactive DFGin 6.9781 14.6249 BLBminus -145.53, 170.39 52.9, 57.73 -61.57, 149.9 287.28, 68.06 -86.96, 168.33 out-out out 16.748 Saltbr-out 14.4128 HRD-in -86.07, -42.21 71.45, -15.9 out-out-out SNCooo out-out ActLoopNT-out 10.2365 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -63.47, 156.15 APE9-dihe-na -125.23, 14.23 APE8-dihe-out -63.17, -28.79 APE8-rot-in 293.42 APE67-dihe-in -53.71, -31.99 -57.23, -35.61 APE12-dist-out 18.4717 APE11-dist-out 18.425 APE10-dist-out 13.9772 APE9-dist-out 11.3055 None None None XRAY 2.49 0.22 0.274 A 306.0 298.0 0 28 28 0 [[4, 286]] 1.0 4ez7 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1AQ1A P24941 1 298 298.0 STU:299 Type1 Inactive DFGin 7.2826 14.9343 BLBplus -138.32, 166.15 50.99, 60.93 -140.99, 149.68 67.4, 106.52 86.86, 1.1 out-out out 14.8878 Saltbr-out 13.1715 HRD-in -84.88, -53.74 82.51, -14.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -59.57, 119.45 APE9-dihe-na -86.87, 141.05 APE8-dihe-in -59.86, 138.54 APE8-rot-out 207.57 APE67-dihe-in -54.1, -30.89 -108.21, -4.5 APE12-dist-none 999.0 APE11-dist-out 16.3195 APE10-dist-out 19.1238 APE9-dist-out 10.6767 None None None XRAY 2.0 0.22 0.26 A 298.0 277.0 21 28 15 13 [[4, 286]] 1.0 1aq1 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7NVQA P24941 1 294 298.0 STU:301 Type1 Inactive DFGin 7.0261 14.7007 BLBplus -138.98, 166.91 60.92, 69.03 -161.06, 162.59 72.07, 108.19 128.48, -14.92 out-out out 14.3509 Saltbr-out 15.1658 HRD-in -80.38, -55.15 83.91, -13.55 out-out-out SNCooo out-out ActLoopNT-out 6.0294 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.14, 127.57 APE9-dihe-na -77.4, 113.59 APE8-dihe-in -55.3, 141.9 APE8-rot-out 195.1 APE67-dihe-in -55.26, -27.26 -100.43, -4.92 APE12-dist-out 18.864 APE11-dist-out 17.7027 APE10-dist-out 18.9757 APE9-dist-out 9.8903 None None None XRAY 2.05 0.24 0.288 A 300.0 287.0 7 28 28 0 [[4, 286]] 1.0 7nvq CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC GSK3B GSK3B_HUMAN 1Q3DA P49841 35 385 420.0 STU:451 Type1 Active DFGin 7.2063 14.4113 BLAminus -139.48, 178.33 63.94, 87.17 -99.43, 23.77 282.58, 69.4 -66.25, -14.58 in-in in 8.701 Saltbr-in 2.8552 HRD-in -65.74, -44.7 66.01, 11.52 in-in-in SNCiii in-in ActLoopNT-in 3.0363 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -94.53, 169.72 APE9-dihe-na 81.56, 143.56 APE8-dihe-in -91.54, 154.32 APE8-rot-in 294.67 APE67-dihe-inflip 96.36, -28.56 -51.12, 132.48 APE12-dist-in 13.0736 APE11-dist-in 11.1082 APE10-dist-in 6.0869 APE9-dist-in 3.274 None None None XRAY 2.2 0.23 0.252 A 424.0 339.0 12 27 27 0 [[56, 340]] 1.0 1q3d CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1Q3DB P49841 35 383 420.0 STU:452 Type1 Active DFGin 7.26 14.4195 BLAminus -137.95, 177.39 64.41, 87.07 -97.99, 22.53 282.7, 70.11 -63.96, -17.29 in-in in 8.7081 Saltbr-in 2.9721 HRD-in -67.72, -45.35 66.86, 12.1 in-in-in SNCiii in-in ActLoopNT-in 3.0238 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -93.75, 170.28 APE9-dihe-na 79.08, 144.81 APE8-dihe-in -89.94, 151.95 APE8-rot-in 299.26 APE67-dihe-inflip 101.61, -31.22 -54.51, 132.99 APE12-dist-in 13.0847 APE11-dist-in 11.0881 APE10-dist-in 6.1457 APE9-dist-in 3.2379 None None None XRAY 2.2 0.23 0.252 B 424.0 339.0 10 27 27 0 [[56, 340]] 1.0 1q3d CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
OTHER ERN1 ERN1_HUMAN 4YZCA O75460 562 963 977.0 STU:1001 Type1 None DFGin 4.5402 13.5982 BLAminus -149.66, -173.45 57.49, 66.53 -77.65, -2.16 287.89, 65.87 -48.01, -38.7 in-none in 9.3632 Saltbr-none 999.0 HRD-in -69.99, -44.37 70.23, -12.54 none-in-in SNCnii in-in ActLoopNT-in 2.8966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -68.95, 160.8 APE9-dihe-na 106.7, 168.85 APE8-dihe-in -105.56, 142.33 APE8-rot-in 309.63 APE67-dihe-inflip 90.78, -21.58 -55.3, 131.97 APE12-dist-in 10.4006 APE11-dist-in 11.3276 APE10-dist-in 5.4058 APE9-dist-in 3.6014 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.494 0.249 0.289 A 405.0 385.0 17 31 30 1 [[571, 832]] 1.0 4yzc OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZCB O75460 562 963 977.0 STU:1001 Type1 None DFGin 4.3622 13.613 BLAminus -140.88, -173.22 59.3, 72.64 -84.99, 5.45 286.37, 62.28 -53.44, -38.69 in-none in 9.6084 Saltbr-none 999.0 HRD-in -70.83, -44.64 74.46, -16.49 none-in-in SNCnii in-in ActLoopNT-in 2.9715 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -78.48, 164.52 APE9-dihe-na 106.87, 177.31 APE8-dihe-in -111.04, 139.81 APE8-rot-in 310.36 APE67-dihe-inflip 90.66, -20.76 -52.98, 131.15 APE12-dist-in 10.8362 APE11-dist-in 11.2328 APE10-dist-in 5.3941 APE9-dist-in 3.6931 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.494 0.249 0.289 B 405.0 384.0 18 31 29 2 [[571, 832]] 1.0 4yzc OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER STK16 STK16_HUMAN 2BUJA O75716 13 299 305.0 STU:61301,STU:61302 Type1,Allosteric Active DFGin 5.2885 13.0033 BLAminus -135.89, -178.46 61.93, 77.23 -105.11, 26.12 316.44, 178.21 -83.9, 1.31 in-in in 9.0243 Saltbr-in 2.9892 HRD-in -74.11, -51.49 80.14, -8.2 in-in-in SNCiii in-in ActLoopNT-in 2.9713 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.51, -7.91 APE9-dihe-na -119.57, 103.56 APE8-dihe-in -42.23, 126.34 APE8-rot-in 303.64 APE67-dihe-in -75.83, -5.68 -58.31, -41.55 APE12-dist-in 12.9195 APE11-dist-in 9.1773 APE10-dist-in 4.9411 APE9-dist-in 4.0001 R19H,R266W None None XRAY 2.6 0.187 0.229 A 317.0 283.0 4 37 37 0 [[20, 292]] 1.0 2buj OTHER_STK16_HUMAN OTHER 4.7e-40 143.7 1.0 258.0 258.0 165 166 167 169 171 49 65 69 145 147 146 148.0 217 202 197 196 195 194 193 192 191 99 Serine/threonine-protein kinase 16
OTHER STK16 STK16_HUMAN 2BUJB O75716 13 297 305.0 STU:61299,STU:61300 Type1,Type1 Active DFGin 5.4737 13.4932 BLAminus -129.22, -175.67 64.04, 67.15 -107.31, -12.83 320.05, 164.52 -59.54, -39.15 in-in in 8.9475 Saltbr-in 2.3744 HRD-in -61.68, -60.28 75.79, -4.77 in-in-in SNCiii in-in ActLoopNT-in 3.1971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.51, -36.93 APE9-dihe-na -101.29, 104.25 APE8-dihe-in -41.65, 126.41 APE8-rot-in 314.22 APE67-dihe-in -74.19, -9.63 -59.55, -34.23 APE12-dist-in 13.9482 APE11-dist-in 10.1855 APE10-dist-in 6.5377 APE9-dist-in 3.6972 R19H,R266W None None XRAY 2.6 0.187 0.229 B 317.0 277.0 8 37 37 0 [[20, 292]] 1.0 2buj OTHER_STK16_HUMAN OTHER 4.7e-40 143.7 1.0 258.0 258.0 165 166 167 169 171 49 65 69 145 147 146 148.0 217 202 197 196 195 194 193 192 191 99 Serine/threonine-protein kinase 16
OTHER TTK TTK_HUMAN 3HMOA P33981 514 794 857.0 STU:1 Type1 Inactive DFGin 4.0338 15.2785 ABAminus -96.9, -14.35 -154.28, 164.59 -116.14, 11.51 302.21, 156.99 70.91, 11.96 out-out out 11.1476 Saltbr-out 6.638 HRD-in -61.3, -53.03 75.35, 1.42 out-out-out SNCooo out-out ActLoopNT-out 11.6803 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -169.39 APE9-dihe-na 94.05, 108.89 APE8-dihe-in -96.62, 156.5 APE8-rot-out 54.19 APE67-dihe-in -64.02, -25.79 -101.71, 14.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.1227 APE9-dist-out 11.5633 None None None XRAY 2.4 0.217 0.261 A 342.0 257.0 24 30 18 12 [[525, 791]] 1.0 3hmo OTHER_TTK_HUMAN CAMK 1.1e-53 188.1 1.0 256.0 256.0 663 664 665 667 669 553 571 575 644 646 645 647.0 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
STE MAP2K6 MP2K6_HUMAN 3FMEA P52564 47 333 334.0 STU:60001 Type1 Inactive None 999.0 999.0 None -108.01, 128.57 -82.08, 37.27 -74.9, 999.0 999.0, 999.0 999.0, 999.0 out-na out 16.0922 Saltbr-na 15.2311 HRD-in -57.54, -47.19 80.18, -0.06 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_nnno APE10-dihe-na 999.0, 108.95 APE9-dihe-na -76.08, 66.3 APE8-dihe-in -91.33, 156.42 APE8-rot-na 298.81 APE67-dihe-out -82.0, 103.94 -93.42, 147.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.9762 S207D,T211D None None XRAY 2.26 0.213 0.236 A 290.0 267.0 20 27 12 15 [[53, 314]] 1.0 3fme STE_MAP2K6_HUMAN STE 3.8e-85 291.3 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
STE MAP3K5 M3K5_HUMAN 4BF2A Q99683 671 939 1374.0 STU:1940 Type1 Inactive DFGin 7.2126 13.8075 BLAminus -114.3, -178.78 51.44, 86.67 -90.54, 15.85 294.66, 96.8 -75.78, -2.2 out-none out 10.049 Saltbr-none 999.0 HRD-in -67.79, -49.78 78.33, -4.9 none-in-out SNCnio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -128.2, 134.23 APE9-dihe-na -68.74, -169.24 APE8-dihe-in -70.38, 133.03 APE8-rot-in 304.95 APE67-dihe-in -66.2, -12.84 -50.6, -52.99 APE12-dist-in 11.0591 APE11-dist-out 5.4399 APE10-dist-out 9.7364 APE9-dist-in 3.5118 T838E None None XRAY 2.11 0.208 0.247 A 334.0 253.0 16 28 22 6 [[678, 938]] 1.0 4bf2 STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5.0 257.0 253.0 821 822 823 825 827 709 725 729 800 802 801 803.0 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 4BF2B Q99683 671 940 1374.0 STU:1941 Type1 Inactive DFGin 6.9205 13.8035 BLAminus -128.63, -177.63 56.0, 77.77 -86.85, 11.45 292.4, 104.75 -69.02, -19.49 in-none in 9.7404 Saltbr-none 999.0 HRD-in -67.52, -45.29 72.76, -9.25 none-in-out SNCnio in-out ActLoopNT-in 3.0123 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 145.57 APE9-dihe-na -77.44, -148.98 APE8-dihe-in -83.86, 130.43 APE8-rot-in 307.99 APE67-dihe-in -59.87, -30.7 -43.72, -58.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.6962 APE9-dist-in 3.5274 T838E None None XRAY 2.11 0.208 0.247 B 334.0 252.0 18 28 19 9 [[678, 938]] 1.0 4bf2 STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5.0 257.0 253.0 821 822 823 825 827 709 725 729 800 802 801 803.0 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 2CLQA Q99683 670 940 1374.0 STU:1941 Type1 Inactive DFGinter 5.9176 8.4686 BABtrans -91.39, 129.8 -141.56, 7.65 -79.81, 110.16 226.87, 94.37 134.88, -46.11 out-out out 10.1274 Saltbr-out 4.7959 HRD-in -81.27, -49.85 78.55, 0.8 out-in-out SNCoio in-out ActLoopNT-in 3.0253 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -136.64, 134.41 APE9-dihe-na -79.2, -159.26 APE8-dihe-in -79.76, 137.19 APE8-rot-in 323.06 APE67-dihe-in -73.67, -16.9 -62.96, -40.27 APE12-dist-in 11.6102 APE11-dist-out 6.2233 APE10-dist-out 10.0395 APE9-dist-in 3.702 None None None XRAY 2.3 0.204 0.257 A 295.0 263.0 8 28 23 5 [[678, 938]] 1.0 2clq STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5.0 257.0 253.0 821 822 823 825 827 709 725 729 800 802 801 803.0 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 2CLQB Q99683 670 940 1374.0 STU:1941 Type1 Inactive DFGinter 6.5637 8.0205 BABtrans -97.55, 126.7 -140.68, 10.18 -79.54, 109.54 215.05, 109.45 130.73, -46.4 in-none in 9.9798 Saltbr-none 999.0 HRD-in -83.48, -49.36 79.39, -1.77 none-in-out SNCnio in-out ActLoopNT-in 3.0007 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -136.24, 136.94 APE9-dihe-na -82.54, -165.1 APE8-dihe-in -71.26, 138.19 APE8-rot-in 313.5 APE67-dihe-in -70.89, -23.23 -61.89, -43.74 APE12-dist-none 999.0 APE11-dist-out 6.2673 APE10-dist-out 10.0131 APE9-dist-in 3.7494 None None None XRAY 2.3 0.204 0.257 B 295.0 259.0 12 28 20 8 [[678, 938]] 1.0 2clq STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5.0 257.0 253.0 821 822 823 825 827 709 725 729 800 802 801 803.0 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE PAK4 PAK4_HUMAN 5VEDA O96013 300 589 591.0 STU:601 Type1 Inactive DFGin 7.5909 14.8713 BLAminus -137.67, -169.84 57.61, 74.14 -100.29, 38.24 286.21, 78.54 -72.3, -31.74 in-out in 8.7707 Saltbr-out 5.2787 HRD-in -70.67, -47.26 60.82, 22.3 out-in-in SNCoii in-in ActLoopNT-in 2.9784 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.74, 169.93 APE9-dihe-na 110.0, -167.24 APE8-dihe-in -107.4, 122.99 APE8-rot-in 313.49 APE67-dihe-in -72.02, -18.93 -37.81, -47.81 APE12-dist-in 8.4933 APE11-dist-in 11.1297 APE10-dist-in 5.2711 APE9-dist-in 3.4124 None SEP474 SEP474 XRAY 2.301 0.231 0.277 A 319.0 290.0 0 28 28 0 [[321, 572]] 1.0 5ved STE_PAK4_HUMAN STE 2.4e-88 301.8 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE STK24 STK24_HUMAN 3CKXA Q9Y6E0 32 310 443.0 STU:60305 Type1 Inactive DFGin 6.5536 14.1491 BLAminus -132.73, 176.63 58.71, 84.09 -98.54, 27.24 290.72, 79.22 -58.51, -31.96 in-out in 8.0183 Saltbr-out 4.1372 HRD-in -69.03, -39.23 63.51, 16.34 out-in-in SNCoii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.66, 153.77 APE9-dihe-na 128.68, -169.17 APE8-dihe-in -106.02, 124.24 APE8-rot-in 327.58 APE67-dihe-in -59.9, -29.27 -40.36, -54.25 APE12-dist-in 8.4325 APE11-dist-in 11.0654 APE10-dist-in 5.4726 APE9-dist-in 3.366 None TPO190 TPO190 XRAY 2.7 0.204 0.268 A 304.0 277.0 2 28 28 0 [[36, 286]] 1.0 3ckx STE_STK24_HUMAN STE 3.6e-100 340.5 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QMYA Q9Y6E0 20 310 443.0 STU:60401 Type1 Active DFGin 6.7458 14.586 BLAminus -133.42, 171.19 64.86, 84.46 -97.43, 25.83 286.76, 75.76 -58.45, -26.25 in-in in 8.7396 Saltbr-in 3.0921 HRD-in -71.07, -50.71 71.45, 2.06 in-in-in SNCiii in-in ActLoopNT-in 2.8283 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.42, 163.67 APE9-dihe-na 122.07, -169.11 APE8-dihe-in -113.85, 118.11 APE8-rot-in 305.93 APE67-dihe-in -57.67, -29.25 -41.23, -48.77 APE12-dist-in 8.3194 APE11-dist-in 10.9316 APE10-dist-in 5.108 APE9-dist-in 3.2458 None TPO190 TPO190 XRAY 1.883 0.18 0.22 A 310.0 288.0 0 28 28 0 [[36, 286]] 1.0 4qmy STE_STK24_HUMAN STE 3.9e-100 340.4 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
TKL IRAK4 IRAK4_HUMAN 2OICA Q9NWZ3 163 458 460.0 STU:1 Type1 Active DFGin 7.5415 14.5501 BLAminus -120.17, -157.79 43.1, 78.64 -95.77, 16.12 291.84, 81.73 -52.42, -46.68 in-in in 9.1643 Saltbr-in 2.7447 HRD-in -70.7, -51.8 81.1, -5.15 in-in-in SNCiii in-in ActLoopNT-in 2.8301 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.11, 162.72 APE9-dihe-na 127.09, -176.82 APE8-dihe-in -109.75, 123.25 APE8-rot-in 303.17 APE67-dihe-in -63.31, -16.61 -48.06, -48.45 APE12-dist-in 10.1333 APE11-dist-in 11.7238 APE10-dist-in 6.3469 APE9-dist-in 3.4459 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 A 301.0 279.0 17 30 24 6 [[183, 456]] 1.0 2oic TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICB Q9NWZ3 164 459 460.0 STU:2 Type1 Active DFGin 7.3007 14.318 BLAminus -135.72, -165.01 43.24, 86.39 -100.56, 27.64 301.91, 89.45 -68.65, -40.8 in-in in 8.997 Saltbr-in 3.0216 HRD-in -70.79, -51.12 80.52, -12.66 in-in-in SNCiii in-in ActLoopNT-in 2.8485 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.84, 167.54 APE9-dihe-na 125.4, -168.64 APE8-dihe-in -121.45, 120.26 APE8-rot-in 302.84 APE67-dihe-in -66.81, -13.26 -49.44, -48.37 APE12-dist-in 10.0934 APE11-dist-in 11.7177 APE10-dist-in 6.031 APE9-dist-in 3.6867 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 B 301.0 278.0 18 30 24 6 [[183, 456]] 1.0 2oic TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICC Q9NWZ3 161 458 460.0 STU:3 Type1 None DFGin 7.6419 14.5124 BLAminus -134.38, -175.33 55.45, 88.83 -103.9, 2.57 299.42, 100.27 -42.77, 999.0 in-in in 9.1756 Saltbr-in 3.2966 HRD-in -70.98, -49.49 84.28, -16.44 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -109.35, 145.04 APE9-dihe-na 142.04, -179.34 APE8-dihe-in -123.52, 118.39 APE8-rot-in 307.07 APE67-dihe-in -69.67, -21.31 -65.38, -24.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.5672 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 C 301.0 280.0 18 30 20 10 [[183, 456]] 1.0 2oic TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICD Q9NWZ3 161 459 460.0 STU:4 Type1 Active DFGin 6.9643 14.7946 BLAminus -128.12, -176.74 47.11, 78.66 -89.74, 11.31 298.87, 93.52 -54.67, -36.62 in-in in 8.7014 Saltbr-in 2.6141 HRD-in -65.25, -53.17 80.56, 0.44 in-in-in SNCiii in-in ActLoopNT-in 2.8622 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.06, 151.9 APE9-dihe-na 143.33, 177.59 APE8-dihe-in -104.02, 127.84 APE8-rot-in 302.2 APE67-dihe-in -61.5, -18.42 -54.54, -50.36 APE12-dist-in 10.5716 APE11-dist-in 11.6739 APE10-dist-in 6.1102 APE9-dist-in 3.4836 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 D 301.0 287.0 12 30 28 2 [[183, 456]] 1.0 2oic TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRYC Q9NWZ3 164 458 460.0 STU:503 Type1 Active DFGin 7.3959 13.9911 BLAminus -129.87, 177.33 66.53, 79.75 -106.36, 3.08 302.75, 99.86 -41.96, -44.4 in-in in 9.0503 Saltbr-in 2.876 HRD-in -69.99, -46.9 74.7, -3.92 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.06, 166.37 APE9-dihe-na 122.8, -162.09 APE8-dihe-in -122.72, 120.05 APE8-rot-in 297.38 APE67-dihe-in -61.23, -20.14 -50.62, -47.6 APE12-dist-in 11.8451 APE11-dist-in 12.224 APE10-dist-in 6.9995 APE9-dist-in 3.8635 None TPO345 TPO345 XRAY 2.15 0.212 0.261 C 307.0 281.0 14 30 26 4 [[183, 456]] 1.0 2nry TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRYD Q9NWZ3 164 460 460.0 STU:501 Type1 Active DFGin 7.1034 14.6012 BLAminus -126.69, 167.35 70.82, 64.69 -93.05, 43.05 345.42, 126.85 -89.85, -18.2 in-in in 9.1762 Saltbr-in 2.9498 HRD-in -59.6, -55.9 83.92, -5.49 in-in-in SNCiii in-in ActLoopNT-in 2.7235 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.15, 176.95 APE9-dihe-na 112.24, -167.34 APE8-dihe-in -128.61, 119.15 APE8-rot-in 302.8 APE67-dihe-in -66.3, -17.75 -48.9, -47.71 APE12-dist-in 10.0254 APE11-dist-in 11.6148 APE10-dist-in 6.2715 APE9-dist-in 3.5382 None TPO345 TPO345 XRAY 2.15 0.212 0.261 D 307.0 283.0 14 30 25 5 [[183, 456]] 1.0 2nry TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U97A Q9NWZ3 166 458 460.0 STU:501 Type1 None DFGin 7.218 14.4948 BLAminus -133.4, -177.52 44.45, 65.76 -75.86, 30.58 295.34, 78.33 -61.24, -17.68 in-in in 9.1113 Saltbr-in 2.7963 HRD-in -81.28, -51.43 74.22, 0.69 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.32, 150.98 APE9-dihe-na 154.49, -177.45 APE8-dihe-in -96.07, 115.4 APE8-rot-in 303.66 APE67-dihe-in -67.54, -17.85 -61.65, -28.02 APE12-dist-in 9.909 APE11-dist-in 11.8395 APE10-dist-in 7.0324 APE9-dist-in 3.8244 D311N None None XRAY 2.65 0.206 0.251 A 312.0 272.0 21 30 22 8 [[183, 456]] 1.0 4u97 TKL_IRAK4_HUMAN TKL 3e-83 285.4 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U9AA Q9NWZ3 166 458 460.0 STU:501 Type1 None DFGin 7.0448 14.9069 BLAminus -101.08, -157.39 29.3, 88.18 -95.05, 25.51 282.71, 82.79 -64.14, 4.87 in-in in 8.9978 Saltbr-in 3.2256 HRD-in -68.43, -44.05 62.5, 13.64 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.36, 146.03 APE9-dihe-na 162.68, -156.1 APE8-dihe-in -121.4, 112.37 APE8-rot-in 316.45 APE67-dihe-in -59.48, -18.83 -58.3, -38.15 APE12-dist-in 9.9834 APE11-dist-in 11.9507 APE10-dist-in 7.2186 APE9-dist-in 3.878 D311N None None XRAY 2.8 0.185 0.24 A 312.0 272.0 21 30 22 8 [[183, 456]] 1.0 4u9a TKL_IRAK4_HUMAN TKL 3e-83 285.4 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRYA Q9NWZ3 164 458 460.0 STU:504 Type1 Inactive DFGin 7.0388 13.8495 BLBminus -119.68, 177.11 59.06, 71.69 -112.23, -126.05 350.98, 70.79 78.1, -70.69 in-in in 9.0302 Saltbr-in 2.7579 HRD-in -65.27, -50.09 77.33, -7.45 in-in-in SNCiii in-in ActLoopNT-in 2.7537 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.61, 161.22 APE9-dihe-na 128.42, -175.43 APE8-dihe-in -120.1, 117.97 APE8-rot-in 299.02 APE67-dihe-in -57.48, -21.15 -43.86, -55.05 APE12-dist-in 10.9882 APE11-dist-in 13.0534 APE10-dist-in 7.6703 APE9-dist-in 3.6824 None TPO345 TPO345 XRAY 2.15 0.212 0.261 A 307.0 287.0 8 30 25 5 [[183, 456]] 1.0 2nry TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRYB Q9NWZ3 164 458 460.0 STU:502 Type1 Inactive DFGin 7.3303 14.2109 BLBminus -121.91, 179.32 63.59, 83.43 -104.91, -160.11 313.36, 100.13 93.41, -69.05 in-out in 8.9923 Saltbr-out 3.7751 HRD-in -74.38, -53.26 85.42, -10.52 out-in-in SNCoii in-in ActLoopNT-in 2.61 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.77, 162.03 APE9-dihe-na 124.37, -168.49 APE8-dihe-in -121.78, 111.1 APE8-rot-in 307.1 APE67-dihe-in -48.86, -28.56 -36.36, -56.5 APE12-dist-in 9.9324 APE11-dist-in 12.1379 APE10-dist-in 6.4849 APE9-dist-in 3.62 None TPO345 TPO345 XRAY 2.15 0.212 0.261 B 307.0 287.0 8 30 25 5 [[183, 456]] 1.0 2nry TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U97B Q9NWZ3 166 458 460.0 STU:501 Type1 Inactive DFGin 5.2944 14.2173 None -136.34, -175.59 46.99, 62.58 -120.73, 999.0 61.34, 86.78 999.0, 999.0 in-in in 9.393 Saltbr-in 2.9962 HRD-in -71.9, -50.3 83.45, -13.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -128.91, -19.36 APE9-dihe-na -55.91, 145.79 APE8-dihe-in -64.15, 91.3 APE8-rot-in 291.9 APE67-dihe-in -57.49, -34.64 -51.29, -30.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.1454 D311N None None XRAY 2.65 0.206 0.251 B 312.0 270.0 23 30 18 12 [[183, 456]] 1.0 4u97 TKL_IRAK4_HUMAN TKL 3e-83 285.4 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U9AB Q9NWZ3 166 458 460.0 STU:501 Type1 Inactive DFGin 5.6327 14.406 None -136.0, 173.79 77.97, 80.6 -165.88, 999.0 67.94, 103.04 999.0, 999.0 in-in in 9.4018 Saltbr-in 2.9242 HRD-in -69.54, -47.75 75.57, 5.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -138.84, -18.64 APE9-dihe-na -63.49, 153.65 APE8-dihe-in -64.27, 92.38 APE8-rot-in 304.32 APE67-dihe-in -63.41, -26.11 -54.68, -17.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.3588 D311N None None XRAY 2.8 0.185 0.24 B 312.0 270.0 23 30 18 12 [[183, 456]] 1.0 4u9a TKL_IRAK4_HUMAN TKL 3e-83 285.4 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL LIMK1 LIMK1_HUMAN 3S95A P53667 330 637 647.0 STU:60001 Type1 Active DFGin 6.5043 14.0715 BLAminus -132.12, 176.01 61.94, 79.29 -96.74, 17.56 299.36, 104.43 -67.12, -24.68 in-in in 7.4783 Saltbr-in 2.7701 HRD-in -69.3, -54.34 71.96, -1.22 in-in-in SNCiii in-in ActLoopNT-in 2.8744 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -137.33, 152.92 APE9-dihe-na 118.99, 175.51 APE8-dihe-in -76.56, 127.6 APE8-rot-na 188.61 APE67-dihe-in -66.82, -23.07 -64.42, -23.72 APE12-dist-in 9.2185 APE11-dist-in 11.4435 APE10-dist-in 5.6449 APE9-dist-in 3.7458 None None None XRAY 1.65 0.157 0.181 A 310.0 288.0 20 42 22 20 [[339, 606]] 1.0 3s95 TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 3S95B P53667 330 637 647.0 STU:60001 Type1 Active DFGin 6.4648 13.7229 BLAminus -137.18, 172.16 66.04, 80.35 -97.8, 13.37 302.38, 103.91 -61.7, -26.69 in-in in 7.8062 Saltbr-in 2.5961 HRD-in -67.95, -51.91 71.9, -3.03 in-in-in SNCiii in-in ActLoopNT-in 2.8557 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -131.01, 146.52 APE9-dihe-na 126.16, 169.25 APE8-dihe-in -67.25, 124.73 APE8-rot-na 183.11 APE67-dihe-in -72.71, -16.93 -64.76, -21.17 APE12-dist-in 9.1152 APE11-dist-in 11.2682 APE10-dist-in 5.4051 APE9-dist-in 3.7833 None None None XRAY 1.65 0.157 0.181 B 310.0 288.0 20 42 22 20 [[339, 606]] 1.0 3s95 TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL RIPK2 RIPK2_HUMAN 5NG2A O43353 5 298 540.0 STU:401 Type1 Inactive DFGin 5.9592 13.8755 BLAminus -127.83, 178.19 61.49, 80.49 -96.67, 24.09 288.33, 78.8 -62.82, -31.8 in-in in 8.0911 Saltbr-in 2.9024 HRD-in -73.87, -50.37 57.71, 19.44 in-in-out SNCiio in-out ActLoopNT-in 2.8273 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 149.89 APE8-dihe-in -77.86, 146.25 APE8-rot-out 189.94 APE67-dihe-in -66.59, -20.81 -105.1, 1.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8555 D146N None None XRAY 2.8 0.209 0.226 A 304.0 274.0 20 33 19 14 [[18, 292]] 1.0 5ng2 TKL_RIPK2_HUMAN TKL 2.6e-72 249.5 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5NG2B O43353 5 298 540.0 STU:401 Type1 Inactive DFGin 5.987 13.9001 BLAminus -127.96, 178.42 61.45, 80.21 -96.5, 23.45 288.92, 78.23 -62.02, -31.71 in-in in 8.0927 Saltbr-in 2.8937 HRD-in -73.84, -50.5 58.4, 18.77 in-in-out SNCiio in-out ActLoopNT-in 2.8272 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.58 APE8-dihe-in -77.44, 145.88 APE8-rot-out 189.53 APE67-dihe-in -67.7, -20.58 -104.84, 1.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.7903 D146N None None XRAY 2.8 0.209 0.226 B 304.0 278.0 16 33 18 15 [[18, 292]] 1.0 5ng2 TKL_RIPK2_HUMAN TKL 2.6e-72 249.5 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL TGFBR1 TGFR1_HUMAN 5E8XA P36897 200 503 503.0 STU:601 Type1 Active DFGin 7.4008 13.7714 BLAminus -132.02, 177.79 68.95, 84.86 -101.89, 20.89 298.69, 99.78 -60.9, -22.78 in-in in 7.6457 Saltbr-in 3.3162 HRD-in -78.83, -50.32 78.23, -2.28 in-in-in SNCiii in-in ActLoopNT-in 2.9268 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.2, 171.93 APE9-dihe-na 104.3, 177.57 APE8-dihe-in -80.96, 119.4 APE8-rot-in 304.53 APE67-dihe-in -55.33, -34.35 -53.44, -41.29 APE12-dist-in 11.7091 APE11-dist-in 11.9272 APE10-dist-in 6.2584 APE9-dist-in 3.9463 T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F None None XRAY 1.45 0.191 0.21 A 307.0 304.0 0 32 32 0 [[205, 494]] 1.0 5e8x TKL_TGFBR1_HUMAN TKL 2.3e-85 292.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 5E8WA P36897 200 501 503.0 STU:60601 Type1 Active DFGin 6.2162 12.9909 BLAminus -115.91, -168.56 48.03, 66.8 -87.81, 6.99 303.66, 6.47 -53.89, -34.67 in-in in 7.5613 Saltbr-in 2.815 HRD-in -71.33, -51.46 73.08, -1.55 in-in-in SNCiii in-in ActLoopNT-in 2.9924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -81.36, -32.83 APE9-dihe-na -81.66, -157.24 APE8-dihe-in -82.54, 122.58 APE8-rot-in 299.35 APE67-dihe-in -53.78, -37.25 -53.32, -45.52 APE12-dist-in 13.0541 APE11-dist-in 12.4184 APE10-dist-in 6.2997 APE9-dist-in 3.7378 T204D None None XRAY 1.86 0.168 0.186 A 307.0 302.0 0 32 32 0 [[205, 494]] 1.0 5e8w TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR2 TGFR2_HUMAN 5E8YA P37173 240 541 567.0 STU:601 Type1 Inactive DFGin 7.4313 13.6382 ABAminus -147.57, -29.88 -97.01, 88.29 -98.27, 19.66 300.85, 114.87 -63.28, -27.98 in-in in 7.6628 Saltbr-in 2.6836 HRD-in -60.19, -53.17 75.99, -7.12 in-in-in SNCiii in-in ActLoopNT-in 2.8159 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.67, 141.68 APE9-dihe-na 119.62, -164.78 APE8-dihe-in -99.54, 120.03 APE8-rot-in 310.13 APE67-dihe-in -59.04, -35.21 -51.44, -37.92 APE12-dist-in 11.2111 APE11-dist-in 12.0735 APE10-dist-in 5.9745 APE9-dist-in 4.0108 E431A,R433A,E485A,K488A,R493A,R495A None None XRAY 2.05 0.198 0.227 A 316.0 298.0 4 32 32 0 [[244, 540]] 1.0 5e8y TKL_TGFBR2_HUMAN TKL 1.9e-77 266.3 2.0 266.0 265.0 396 397 398 400 402 277 290 294 376 378 377 379.0 446 428 423 422 421 420 419 418 417 326 TGF-beta receptor type-2
TYR ALK ALK_HUMAN 3LCSA Q9UM73 1096 1399 1620.0 STU:1 Type1 Inactive DFGin 6.3299 14.9123 ABAminus -115.64, -37.74 -102.74, 114.2 -112.42, 20.01 289.12, 86.66 -56.01, -38.26 in-in in 7.78 Saltbr-in 2.6618 HRD-in -69.52, -44.32 78.89, -12.54 in-out-out SNCioo out-out ActLoopNT-out 6.7937 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.07, -13.05 APE9-dihe-in -64.04, 139.47 APE8-dihe-in -80.51, 60.39 APE8-rot-na 31.54 APE67-dihe-in -67.01, -14.6 -60.37, -27.86 APE12-dist-na 15.3078 APE11-dist-na 15.5689 APE10-dist-na 10.5385 APE9-dist-out 8.2956 S1281G None None XRAY 1.95 0.196 0.229 A 344.0 304.0 0 30 30 0 [[1116, 1385]] 1.0 3lcs TYR_ALK_HUMAN TYR 5e-90 307.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR CSK CSK_HUMAN 3D7TA P41240 188 450 450.0 STU:6335 Type1 Inactive DFGin 4.8478 13.7273 None -129.86, -75.48 -112.49, 120.17 -68.38, 132.53 310.55, 71.3 -108.94, 999.0 in-in in 9.7085 Saltbr-in 3.505 HRD-in -84.81, -41.33 76.65, -6.36 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 92.32 APE8-rot-na 27.67 APE67-dihe-in -57.33, -30.65 -43.31, -55.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K361A,K362A None None XRAY 2.899 0.239 0.278 A 269.0 249.0 14 25 11 14 [[195, 442]] 1.0 3d7t TYR_CSK_HUMAN TYR 5.7e-87 297.2 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
TYR CSK CSK_HUMAN 1BYGA P41240 187 448 450.0 STU:501 Type1 Inactive DFGinter 10.8596 7.9227 BABtrans -99.17, 153.06 -105.84, -7.01 -68.56, 146.18 156.4, 90.07 -161.79, 133.09 out-out out 14.7753 Saltbr-out 12.6461 HRD-in -79.54, -44.6 72.05, -5.51 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.52 APE8-dihe-in -71.25, 96.92 APE8-rot-na 16.81 APE67-dihe-in -75.84, -8.12 -42.46, -43.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2924 None None None XRAY 2.4 0.199 0.287 A 278.0 246.0 16 25 13 12 [[195, 442]] 1.0 1byg TYR_CSK_HUMAN TYR 1.2e-87 299.5 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
TYR EPHB4 EPHB4_HUMAN 3ZEWA P54760 609 888 987.0 STU:1889 Type1 None DFGin 6.1222 14.3588 BLAminus -139.16, 174.72 57.83, 79.91 -97.95, 22.7 299.52, 94.02 -63.4, -45.19 in-in in 8.066 Saltbr-in 2.7962 HRD-in -71.2, -51.67 69.26, -8.65 in-in-none SNCiin in-none ActLoopNT-in 2.8209 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 56.2 APE9-dihe-in -113.28, 124.67 APE8-dihe-in -75.39, 88.73 APE8-rot-na 23.8 APE67-dihe-in -74.18, -2.68 -39.84, -58.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.2917 APE9-dist-in 6.0712 None PTR774 PTR774 XRAY 2.5 0.24 0.282 A 298.0 270.0 10 33 27 6 [[615, 876]] 1.0 3zew TYR_EPHB4_HUMAN TYR 2.6e-104 354.1 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 3ZEWB P54760 609 887 987.0 STU:1888 Type1 None DFGin 6.5999 14.6897 BLAminus -136.46, 179.33 65.25, 57.03 -88.32, 123.85 306.76, 101.31 132.26, 999.0 in-none in 7.638 Saltbr-none 999.0 HRD-in -68.01, -45.09 76.33, -22.89 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.88 APE8-dihe-in -93.06, 95.29 APE8-rot-na 27.85 APE67-dihe-in -68.25, -2.97 -47.06, -56.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5541 None PTR774 PTR774 XRAY 2.5 0.24 0.282 B 298.0 252.0 27 33 12 21 [[615, 876]] 1.0 3zew TYR_EPHB4_HUMAN TYR 2.6e-104 354.1 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2YN8A P54760 608 888 987.0 STU:1889 Type1 Inactive DFGin 6.4266 14.6174 None -130.9, 178.33 70.32, 85.06 -121.95, 999.0 309.1, 102.44 999.0, 999.0 in-in in 7.5327 Saltbr-in 2.7506 HRD-in -74.77, -43.96 71.71, -21.91 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.38 APE8-rot-na 24.51 APE67-dihe-in -59.12, -26.62 -41.36, -49.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y774E,A803V,V870I None None XRAY 2.11 0.197 0.234 A 298.0 253.0 28 33 10 23 [[615, 876]] 1.0 2yn8 TYR_EPHB4_HUMAN TYR 4.3e-105 356.6 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2YN8B P54760 606 888 987.0 STU:1889 Type1 Inactive DFGin 6.4286 14.6268 None -131.1, 178.0 70.17, 85.21 -120.37, 999.0 309.66, 103.01 999.0, 999.0 in-in in 7.4864 Saltbr-in 2.7603 HRD-in -75.37, -48.88 76.16, -20.77 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.61 APE8-rot-na 24.46 APE67-dihe-in -59.58, -26.36 -40.69, -50.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y774E,A803V,V870I None None XRAY 2.11 0.197 0.234 B 298.0 260.0 23 33 10 23 [[615, 876]] 1.0 2yn8 TYR_EPHB4_HUMAN TYR 4.3e-105 356.6 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR FES FES_HUMAN 3BKBA P07332 449 821 822.0 STU:826 Type1 Inactive DFGin 6.8661 14.4239 BLAminus -130.98, -162.57 38.75, 71.71 -85.89, 14.89 281.41, 76.5 -59.73, -36.44 in-in in 6.7723 Saltbr-in 2.6204 HRD-in -78.26, -50.49 76.66, -9.4 in-in-out SNCiio in-out ActLoopNT-in 2.8204 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 47.37, 40.72 APE9-dihe-in -62.75, 132.26 APE8-dihe-in -76.49, 72.71 APE8-rot-na 30.4 APE67-dihe-in -70.68, -13.35 -50.64, -47.62 APE12-dist-na 8.3405 APE11-dist-na 11.9812 APE10-dist-na 11.2254 APE9-dist-in 7.3541 None None None XRAY 1.78 0.15 0.189 A 377.0 373.0 0 30 30 0 [[561, 816]] 1.0 3bkb TYR_FES_HUMAN TYR 6.6e-94 320.0 1.0 260.0 260.0 700 701 702 704 706 590 607 611 680 682 681 683.0 742 730 725 724 723 722 721 720 719 637 Tyrosine-protein kinase Fes/Fps
TYR FES FES_HUMAN 3CBLA P07332 448 821 822.0 STU:60901,STU:60902,STU:60903 Type1,Allosteric,Allosteric Active DFGin 6.9919 14.3472 BLAminus -129.39, -161.99 36.63, 77.42 -90.17, 19.41 283.19, 78.42 -59.92, -34.07 in-in in 7.0184 Saltbr-in 2.618 HRD-in -73.99, -51.91 78.82, -2.64 in-in-in SNCiii in-in ActLoopNT-in 2.7424 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.35, 116.24 APE9-dihe-in -118.34, 122.46 APE8-dihe-in -80.03, 88.22 APE8-rot-na 26.81 APE67-dihe-in -66.64, -12.19 -59.28, -46.73 APE12-dist-na 13.8621 APE11-dist-na 9.6806 APE10-dist-na 8.625 APE9-dist-in 6.8668 None None None XRAY 1.75 0.183 0.227 A 377.0 354.0 0 30 30 0 [[561, 816]] 1.0 3cbl TYR_FES_HUMAN TYR 6.6e-94 320.0 1.0 260.0 260.0 700 701 702 704 706 590 607 611 680 682 681 683.0 742 730 725 724 723 722 721 720 719 637 Tyrosine-protein kinase Fes/Fps
TYR FES FES_HUMAN 3CD3A P07332 448 821 822.0 STU:60901,STU:60902,STU:60903 Type1,Allosteric,Allosteric Active DFGin 7.0423 14.319 BLAminus -131.29, -161.96 36.95, 76.94 -87.41, 20.64 283.25, 80.52 -64.77, -30.01 in-in in 6.9546 Saltbr-in 2.4508 HRD-in -75.66, -48.21 74.09, -7.23 in-in-in SNCiii in-in ActLoopNT-in 2.8131 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.76, 114.63 APE9-dihe-in -118.9, 123.98 APE8-dihe-in -79.16, 82.58 APE8-rot-na 23.88 APE67-dihe-in -66.61, -9.96 -49.19, -54.65 APE12-dist-na 14.1032 APE11-dist-na 10.0433 APE10-dist-na 8.9304 APE9-dist-in 7.039 None PTR713 PTR713 XRAY 1.98 0.188 0.247 A 377.0 351.0 4 30 30 0 [[561, 816]] 1.0 3cd3 TYR_FES_HUMAN TYR 6.6e-94 320.0 1.0 260.0 260.0 700 701 702 704 706 590 607 611 680 682 681 683.0 742 730 725 724 723 722 721 720 719 637 Tyrosine-protein kinase Fes/Fps
TYR FYN FYN_HUMAN 2DQ7X P06241 261 523 537.0 STU:60902 Type1 Active DFGin 6.9701 13.8533 BLAminus -137.79, 173.21 69.46, 82.83 -98.97, 30.24 286.34, 86.38 -56.5, -37.75 in-in in 7.7541 Saltbr-in 2.468 HRD-in -90.12, -49.46 72.41, 2.38 in-in-in SNCiii in-in ActLoopNT-in 2.8825 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.8, 126.18 APE9-dihe-in -111.81, 159.77 APE8-dihe-in -55.65, 79.81 APE8-rot-na 29.61 APE67-dihe-in -72.56, -28.8 -30.08, -40.64 APE12-dist-na 13.298 APE11-dist-na 8.6792 APE10-dist-na 12.4565 APE9-dist-in 6.2157 None PTR420 PTR420 XRAY 2.8 0.255 0.281 X 283.0 263.0 0 29 29 0 [[271, 522]] 1.0 2dq7 TYR_FYN_HUMAN TYR 2.6e-94 321.3 1.0 260.0 260.0 407 408 409 411 413 299 314 318 387 389 388 390.0 448 436 431 430 429 428 427 426 425 343 Tyrosine-protein kinase Fyn
TYR ITK ITK_HUMAN 1SM2A Q08881 357 619 620.0 STU:301 Type1 Inactive DFGin 5.4974 13.3207 BLBplus -148.18, -157.96 48.2, 18.11 -92.5, -172.62 59.26, 91.5 71.27, 999.0 out-out out 10.5039 Saltbr-out 8.0102 HRD-out -81.72, 93.89 -66.35, 12.1 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.52 APE8-rot-na 340.44 APE67-dihe-in -77.92, -11.34 -60.73, -6.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.246 0.292 A 264.0 245.0 18 29 11 18 [[363, 614]] 1.0 1sm2 TYR_ITK_HUMAN TYR 9.2e-93 316.2 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SNUA Q08881 357 619 620.0 STU:301 Type1 Inactive DFGin 5.4095 13.5857 BLBplus -121.03, -147.07 39.99, 19.77 -95.61, 161.03 65.42, 97.15 81.16, 999.0 out-out out 10.9852 Saltbr-out 7.7298 HRD-out -99.78, 92.32 -72.7, 37.05 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.98 APE8-rot-na 339.02 APE67-dihe-in -71.29, -26.27 -59.31, -15.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.262 0.295 A 264.0 245.0 18 29 11 18 [[363, 614]] 1.0 1snu TYR_ITK_HUMAN TYR 9.2e-93 316.2 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SM2B Q08881 358 617 620.0 STU:621 Type1 Inactive DFGin 5.378 13.3785 None -126.46, -161.15 38.96, 42.72 -115.58, 999.0 63.86, 78.79 999.0, 999.0 out-out out 11.099 Saltbr-out 6.8051 HRD-out -89.1, 89.71 -64.14, 17.77 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 70.78 APE8-rot-na 24.5 APE67-dihe-in -53.23, -18.63 -53.68, -42.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.246 0.292 B 264.0 241.0 19 29 10 19 [[363, 614]] 1.0 1sm2 TYR_ITK_HUMAN TYR 9.2e-93 316.2 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SNUB Q08881 358 617 620.0 STU:621 Type1 Inactive DFGin 5.3215 13.3612 None -135.24, -161.39 47.41, 33.44 -112.08, 999.0 66.07, 77.87 999.0, 999.0 out-out out 11.1179 Saltbr-out 7.4836 HRD-out -85.26, 96.7 -69.16, 21.34 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 61.67 APE8-rot-na 31.48 APE67-dihe-in -68.53, -31.16 -49.5, -27.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.262 0.295 B 264.0 241.0 19 29 10 19 [[363, 614]] 1.0 1snu TYR_ITK_HUMAN TYR 9.2e-93 316.2 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR KIT KIT_HUMAN 8S19A P10721 566 931 976.0 STU:61001 Type1 Active DFGin 7.4038 13.6674 BLAminus -127.12, -176.58 57.62, 86.03 -104.33, 27.64 287.94, 75.89 -65.62, -32.19 in-in in 8.5279 Saltbr-in 2.8072 HRD-in -86.95, -44.99 76.04, 4.46 in-in-in SNCiii in-in ActLoopNT-in 2.9798 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.78, 135.36 APE9-dihe-in -116.81, 146.55 APE8-dihe-in -80.8, 82.76 APE8-rot-na 31.59 APE67-dihe-in -71.09, -10.53 -60.41, -40.84 APE12-dist-na 14.6501 APE11-dist-na 10.0069 APE10-dist-na 13.4676 APE9-dist-in 7.8988 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.3 0.186 0.208 A 327.0 287.0 1 30 29 1 [[589, 926]] 1.0 8s19 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1.0 261.0 261.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 8S19B P10721 566 930 976.0 STU:61001 Type1 Active DFGin 7.3271 13.5376 BLAminus -128.07, -176.35 62.24, 79.08 -101.65, 27.17 286.46, 78.41 -65.78, -31.3 in-in in 8.4236 Saltbr-in 3.2444 HRD-in -86.63, -46.82 74.21, 3.84 in-in-in SNCiii in-in ActLoopNT-in 2.9724 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.88, 148.22 APE9-dihe-in -128.01, 146.9 APE8-dihe-in -81.2, 79.5 APE8-rot-na 31.77 APE67-dihe-in -74.43, -9.18 -60.72, -38.08 APE12-dist-na 14.1209 APE11-dist-na 10.1321 APE10-dist-na 13.2289 APE9-dist-in 7.6951 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.3 0.186 0.208 B 327.0 284.0 3 30 30 0 [[589, 926]] 1.0 8s19 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1.0 261.0 261.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR LCK LCK_HUMAN 1QPJA P06239 236 501 509.0 STU:902 Type1 Active DFGin 6.6673 13.9099 BLAminus -132.46, 174.81 60.31, 82.59 -95.23, 22.99 299.73, 90.17 -64.21, -26.94 in-in in 8.1293 Saltbr-in 2.566 HRD-in -98.38, -45.69 71.81, -4.26 in-in-in SNCiii in-in ActLoopNT-in 2.8829 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.6, 145.72 APE9-dihe-in -137.74, 152.71 APE8-dihe-in -60.2, 95.29 APE8-rot-na 326.72 APE67-dihe-in -63.01, -25.44 -48.62, -46.8 APE12-dist-na 14.7028 APE11-dist-na 10.0918 APE10-dist-na 12.9477 APE9-dist-in 7.0162 None PTR394 PTR394 XRAY 2.2 0.214 0.267 A 279.0 266.0 0 29 29 0 [[245, 496]] 1.0 1qpj TYR_LCK_HUMAN TYR 1.4e-94 322.2 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TYR LCK LCK_HUMAN 1QPDA P06239 231 502 509.0 STU:902 Type1 Active DFGin 6.4653 14.1815 BLAminus -132.18, 176.72 55.71, 84.19 -94.48, 25.19 297.78, 91.73 -59.44, -39.94 in-in in 8.4176 Saltbr-in 2.8434 HRD-in -101.42, -45.84 73.23, 2.58 in-in-in SNCiii in-in ActLoopNT-in 2.9762 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.47, 143.78 APE9-dihe-in -134.7, 155.74 APE8-dihe-in -59.6, 112.24 APE8-rot-na 334.8 APE67-dihe-in -60.08, -21.25 -55.42, -48.02 APE12-dist-na 14.972 APE11-dist-na 10.2937 APE10-dist-na 12.9671 APE9-dist-in 6.9506 None PTR394 PTR394 XRAY 2.0 0.195 0.237 A 279.0 272.0 0 29 29 0 [[245, 496]] 1.0 1qpd TYR_LCK_HUMAN TYR 3.6e-93 317.5 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TYR LYN LYN_HUMAN 3A4OX P07948 238 505 512.0 STU:60902 Type1 Inactive DFGin 6.6497 15.5814 None -103.69, -177.97 54.14, 148.85 -166.58, 42.86 276.85, 106.11 -75.66, -40.91 in-in in 9.1227 Saltbr-in 3.2202 HRD-in -82.15, -55.06 93.66, -27.17 in-in-out SNCiio in-out ActLoopNT-in 2.8615 ActLoopCT-out TYR APEdihe_ooiai APEdist_aaai APE10-dihe-out -155.78, -36.41 APE9-dihe-out 3.09, -67.88 APE8-dihe-in -48.66, 80.66 APE8-rot-na 28.53 APE67-dihe-in -67.02, 39.44 -53.16, -65.62 APE12-dist-na 7.583 APE11-dist-na 3.3978 APE10-dist-na 8.537 APE9-dist-in 6.4504 None None None XRAY 3.0 0.293 0.324 X 286.0 259.0 9 29 20 9 [[247, 499]] 1.0 3a4o TYR_LYN_HUMAN TYR 1.2e-95 325.7 1.0 260.0 260.0 384 385 386 388 390 275 290 294 364 366 365 367.0 425 413 408 407 406 405 404 403 402 320 Tyrosine-protein kinase Lyn
TYR NTRK1 NTRK1_HUMAN 9DAIA P04629 501 796 796.0 STU:801 Type1 Inactive DFGin 7.3285 15.1025 None -134.39, -155.28 28.01, 68.03 -73.72, 999.0 288.62, 88.06 999.0, 999.0 in-in in 9.6981 Saltbr-in 3.2532 HRD-in -62.59, -42.57 78.74, -33.91 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.11 APE8-dihe-in -86.91, 69.17 APE8-rot-na 30.89 APE67-dihe-in -62.36, -34.09 -52.62, -31.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4955 None None None XRAY 2.864 0.22 0.277 A 320.0 264.0 32 30 11 19 [[510, 783]] 1.0 9dai TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR SYK KSYK_HUMAN 1XBCA P43405 363 635 635.0 STU:60001 Type1 Active DFGin 6.6992 14.2365 BLAminus -133.2, -171.25 54.9, 81.04 -97.63, 25.87 287.7, 80.31 -62.67, -30.77 in-in in 8.107 Saltbr-in 2.6812 HRD-in -73.91, -54.08 72.64, 5.62 in-in-in SNCiii in-in ActLoopNT-in 2.8734 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.93, 102.31 APE9-dihe-in -115.14, 122.86 APE8-dihe-in -77.21, 74.28 APE8-rot-na 27.13 APE67-dihe-in -62.04, -14.77 -51.56, -42.64 APE12-dist-na 10.2255 APE11-dist-na 10.6613 APE10-dist-na 9.591 APE9-dist-in 6.8302 None None None XRAY 2.0 0.246 0.294 A 291.0 267.0 6 31 31 0 [[370, 628]] 1.0 1xbc TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR ZAP70 ZAP70_HUMAN 1U59A P43403 328 606 619.0 STU:60100 Type1 Inactive DFGin 6.4492 14.6547 BLAminus -132.39, 179.54 60.68, 79.94 -93.24, 26.52 286.21, 85.42 -61.36, -30.97 in-in in 8.5451 Saltbr-in 2.6048 HRD-in -75.34, -52.46 82.3, -36.8 in-in-out SNCiio in-out ActLoopNT-in 2.9844 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -109.77, 150.26 APE9-dihe-in -93.67, 137.73 APE8-dihe-in -75.36, 68.87 APE8-rot-na 32.83 APE67-dihe-in -59.55, -7.44 -43.09, -46.01 APE12-dist-na 14.4853 APE11-dist-na 13.5249 APE10-dist-na 14.7003 APE9-dist-out 9.0998 None None None XRAY 2.3 0.217 0.271 A 287.0 276.0 3 31 31 0 [[338, 595]] 1.0 1u59 TYR_ZAP70_HUMAN TYR 2.5e-90 308.2 6.0 259.0 254.0 478 479 480 482 484 369 386 390 458 460 459 461.0 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70

Ligand: STU

Total number of chains: 131
Active chains: 31
Total number of genes: 47
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 71 54.2% 5E8XA
DFGin ABAminus 21 16.0% 4C34A
DFGin None 19 14.5% 6B1UA
DFGin BLBplus 6 4.6% 7NVQA
DFGin BLBminus 4 3.1% 4EZ7A
None None 4 3.1% 3FMEA
DFGinter BABtrans 3 2.3% 2CLQA
DFGout None 2 1.5% 3D7TB
DFGin BLAplus 1 0.8% 5LOHA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL CTR1 CTR1_ARATH 3PPZA Q05609 540 810 821.0 STU:1 Type1 Active DFGin 7.1683 14.1759 BLAminus -141.04, 175.37 60.27, 75.13 -95.53, 20.67 299.73, 103.42 -61.37, -41.48 in-in in 9.2355 Saltbr-in 3.0989 HRD-in -68.66, -37.79 67.09, -5.56 in-in-in SNCiii in-in ActLoopNT-in 3.1696 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.6, 161.97 APE9-dihe-na 135.37, 159.66 APE8-dihe-in -74.98, 124.27 APE8-rot-in 310.73 APE67-dihe-in -59.97, -23.72 -59.94, -40.82 APE12-dist-in 7.4492 APE11-dist-in 10.7563 APE10-dist-in 6.0215 APE9-dist-in 3.9622 None TPO704,SEP707,SEP710 TPO704,SEP707,SEP710 XRAY 2.99 0.204 0.256 A 309.0 267.0 4 28 28 0 [[551, 807]] 1.0 3ppz Arabidopsis thaliana TKL_CTR1_ARATH TKL 5e-79 271.5 2.0 265.0 264.0 693 694 695 697 699 578 596 600 673 675 674 676.0 733 721 716 715 714 713 712 711 710 626 Serine/threonine-protein kinase CTR1
TKL CTR1 CTR1_ARATH 3P86A Q05609 544 810 821.0 STU:0 Type1 Inactive DFGout 11.6989 11.4173 None -88.96, 103.02 -108.84, 121.4 -126.5, 999.0 59.02, 88.01 999.0, 999.0 out-out out 11.0091 Saltbr-out 6.0815 HRD-out -107.29, 93.48 -77.8, -17.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -129.5 APE8-dihe-in -88.96, 138.18 APE8-rot-out 51.6 APE67-dihe-in -62.6, -7.91 -94.5, 4.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.4622 D676N None None XRAY 2.496 0.197 0.232 A 309.0 250.0 17 28 11 17 [[551, 807]] 1.0 3p86 Arabidopsis thaliana TKL_CTR1_ARATH TKL 3.2e-78 268.9 2.0 265.0 264.0 693 694 695 697 699 578 596 600 673 675 674 676.0 733 721 716 715 714 713 712 711 710 626 Serine/threonine-protein kinase CTR1
AGC GRK2 ARBK1_BOVIN 8JPBG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.5082 12.2136 ABAminus -113.28, -56.44 -93.74, 100.06 -93.25, 26.0 307.53, 3.55 -63.32, -43.2 in-out in 8.9334 Saltbr-out 4.2174 HRD-out -93.17, 87.64 -73.74, -9.71 out-in-in SNCoii in-in ActLoopNT-in 2.7258 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.15, 142.89 APE9-dihe-na 142.59, -152.8 APE8-dihe-in -124.3, 137.48 APE8-rot-in 299.05 APE67-dihe-inflip 90.41, -8.27 -58.8, 137.88 APE12-dist-in 9.9025 APE11-dist-in 12.0099 APE10-dist-in 6.0986 APE9-dist-in 3.6298 A292P,R295I,S455D None None EM 3.07 999.0 999.0 G 688.0 658.0 0 26 26 0 [[191, 453]] 1.0 8jpb Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 8JPCG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.385 12.1571 ABAminus -113.22, -56.58 -93.6, 101.44 -93.44, 27.48 306.81, 9.79 -63.79, -45.14 in-out in 8.9895 Saltbr-out 4.6535 HRD-out -92.62, 94.67 -75.66, -35.58 out-in-in SNCoii in-in ActLoopNT-in 2.6526 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.27, 130.92 APE9-dihe-na 162.84, -151.71 APE8-dihe-in -129.7, 130.81 APE8-rot-in 302.62 APE67-dihe-inflip 97.48, -17.5 -57.09, 134.46 APE12-dist-in 9.7132 APE11-dist-in 11.9892 APE10-dist-in 5.9887 APE9-dist-in 4.3163 A292P,R295I,S455D None None EM 3.07 999.0 999.0 G 688.0 658.0 0 26 26 0 [[191, 453]] 1.0 8jpc Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 8JPDG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.3847 12.1571 ABAminus -113.24, -56.55 -93.57, 101.39 -93.42, 27.53 306.84, 9.79 -63.78, -45.12 in-out in 8.9895 Saltbr-out 4.6534 HRD-out -92.61, 94.65 -75.65, -35.58 out-in-in SNCoii in-in ActLoopNT-in 2.6534 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.32, 130.92 APE9-dihe-na 162.83, -151.7 APE8-dihe-in -129.72, 130.82 APE8-rot-in 302.58 APE67-dihe-inflip 97.48, -17.49 -57.11, 134.43 APE12-dist-in 9.7137 APE11-dist-in 11.9887 APE10-dist-in 5.9885 APE9-dist-in 4.3171 A292P,R295I,S455D None None EM 2.81 999.0 999.0 G 688.0 658.0 0 26 26 0 [[191, 453]] 1.0 8jpd Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC PRKACA KAPCA_BOVIN 1STCE P00517 16 351 351.0 STU:60351 Type1 Inactive DFGin 6.1254 14.6764 ABAminus -152.28, -21.25 -98.94, 113.28 -112.23, 27.12 284.07, 102.64 -65.61, -29.61 in-in in 9.1737 Saltbr-in 2.6077 HRD-out -84.15, -57.61 42.07, 55.99 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.84, 156.46 APE9-dihe-na 129.45, -158.0 APE8-dihe-in -121.73, 124.56 APE8-rot-in 292.46 APE67-dihe-in -75.12, -21.46 -28.7, -46.78 APE12-dist-in 8.3869 APE11-dist-in 11.1625 APE10-dist-in 5.8257 APE9-dist-in 4.4432 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.3 0.208 0.33 E 350.0 336.0 0 25 25 0 [[44, 298]] 1.0 1stc Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 4C34A P00517 11 351 351.0 STU:61351 Type1 Inactive DFGin 6.5166 14.8494 ABAminus -119.31, -40.44 -98.64, 112.68 -107.28, 23.29 283.36, 88.13 -59.12, -19.89 in-in in 8.8642 Saltbr-in 2.9854 HRD-in -78.06, -54.1 69.84, 7.38 in-in-in SNCiii in-in ActLoopNT-in 2.9107 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.66, 162.66 APE9-dihe-na 118.12, -166.39 APE8-dihe-in -111.07, 134.19 APE8-rot-in 303.77 APE67-dihe-in -56.72, -26.94 -46.04, -52.13 APE12-dist-in 8.3983 APE11-dist-in 11.4581 APE10-dist-in 5.7648 APE9-dist-in 3.4077 F55Y,M121L,V124L,L174M,Q182K SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.78 0.18 0.214 A 351.0 340.0 0 25 25 0 [[44, 298]] 1.0 4c34 Bos taurus AGC_PRKACA_BOVIN AGC 7.8e-94 319.7 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
TYR SRC SRC_CHICK 3D7TB P00523 258 533 533.0 STU:6334 Type1 Inactive DFGout 12.8141 10.1214 None -137.48, -160.64 -79.66, 41.23 -140.31, 108.32 334.97, 53.33 120.28, -36.98 in-in in 8.0289 Saltbr-in 2.6221 HRD-in -81.72, -43.05 80.64, -35.93 in-out-none SNCion out-none ActLoopNT-out 5.4127 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 102.99 APE9-dihe-in -85.23, 141.01 APE8-dihe-in -81.53, 111.41 APE8-rot-na 348.05 APE67-dihe-in -53.4, -28.51 -45.34, -53.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.2899 APE9-dist-in 5.671 None None None XRAY 2.899 0.239 0.278 B 286.0 265.0 11 29 18 11 [[267, 518]] 1.0 3d7t Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
AGC MASTL GWL_HUMAN 5LOHA Q96GX5 30 854 879.0 STU:60901 Type1 Inactive DFGin 10.8403 13.5188 BLAplus -154.04, -179.93 62.84, 37.43 -106.51, -23.39 59.72, 80.58 -168.74, -25.48 none-none none 999.0 Saltbr-none 999.0 HRD-in -59.31, -45.76 66.7, 4.42 none-out-out SNCnoo out-out ActLoopNT-out 8.33 ActLoopCT-out nonTYR APEdihe_aanon APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 165.16 APE8-dihe-none -79.14, 999.0 APE8-rot-out 44.79 APE67-dihe-none -72.42, -27.62 999.0, 33.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8912 None None None XRAY 3.1 0.209 0.265 A 341.0 246.0 34 28 13 15 [[35, 835]] 1.0 5loh Homo sapiens AGC_MASTL_HUMAN AGC 4e-131 441.8 1.0 260.0 260.0 173 174 175 177 179 62 81 85 153 155 154 156.0 760 201 196 195 741 740 -9999 -9999 -9999 111 Serine/threonine-protein kinase greatwall
AGC MASTL GWL_HUMAN 5LOHB Q96GX5 30 854 879.0 STU:60901 Type1 Inactive None 999.0 13.3388 None -152.85, -174.25 66.27, 69.27 -150.61, -21.46 41.33, 82.81 -90.34, 22.29 none-none none 999.0 Saltbr-none 999.0 HRD-in -60.11, -44.59 64.53, 4.15 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aannn APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -141.8 APE8-dihe-none -77.31, 999.0 APE8-rot-none 999.0 APE67-dihe-none 49.84, -65.93 999.0, -82.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7129 None None None XRAY 3.1 0.209 0.265 B 341.0 250.0 30 28 11 17 [[35, 835]] 1.0 5loh Homo sapiens AGC_MASTL_HUMAN AGC 4e-131 441.8 1.0 260.0 260.0 173 174 175 177 179 62 81 85 153 155 154 156.0 760 201 196 195 741 740 -9999 -9999 -9999 111 Serine/threonine-protein kinase greatwall
AGC PDPK1 PDPK1_HUMAN 1OKYA O15530 72 360 556.0 STU:1368 Type1 Inactive DFGin 6.1532 14.4616 BLAminus -148.97, -170.84 70.56, 80.45 -102.75, 23.82 286.84, 96.04 -69.28, -20.21 in-in in 8.6718 Saltbr-in 2.6729 HRD-in -67.69, -57.78 80.28, 0.43 in-in-out SNCiio in-out ActLoopNT-in 2.9341 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.7, -80.59 APE9-dihe-na 115.49, 169.91 APE8-dihe-in -54.49, 123.73 APE8-rot-in 316.76 APE67-dihe-in -63.35, -17.55 -42.07, -50.54 APE12-dist-in 9.2892 APE11-dist-out 5.5558 APE10-dist-out 9.7186 APE9-dist-in 4.222 None SEP241 SEP241 XRAY 2.3 0.219 0.255 A 310.0 283.0 6 30 24 6 [[82, 342]] 1.0 1oky Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PRKCQ KPCT_HUMAN 1XJDA Q04759 377 696 706.0 STU:200 Type1 Active DFGin 5.8284 13.1925 BLAminus -132.69, 162.8 69.28, 95.13 -109.8, 21.13 305.67, 104.94 -64.79, -17.76 in-in in 8.0639 Saltbr-in 2.5131 HRD-in -67.27, -48.59 64.56, -1.72 in-in-in SNCiii in-in ActLoopNT-in 2.9684 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.73, 166.78 APE9-dihe-na 120.3, 163.8 APE8-dihe-in -75.86, 125.98 APE8-rot-in 298.87 APE67-dihe-in -57.15, -29.94 -38.43, -48.34 APE12-dist-in 9.0296 APE11-dist-in 12.2938 APE10-dist-in 6.8961 APE9-dist-in 3.7669 None TPO538,SEP695 TPO538,SEP695 XRAY 2.0 0.201 0.216 A 345.0 282.0 0 28 28 0 [[380, 634]] 1.0 1xjd Homo sapiens AGC_PRKCQ_HUMAN AGC 1.2e-95 325.5 1.0 260.0 260.0 521 522 523 525 527 409 428 432 501 503 502 504.0 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC RPS6KA1-1 KS6A1_HUMAN 2Z7RA Q15418 53 340 735.0 STU:1 Type1 Inactive DFGin 6.9283 12.3219 BLBplus -135.18, 169.76 58.7, 61.01 -129.8, -169.31 56.27, 83.01 123.62, -72.1 none-none none 999.0 Saltbr-none 999.0 HRD-out -70.75, 75.42 -55.39, -34.53 none-out-out SNCnoo out-out ActLoopNT-out 7.3785 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.4 APE8-dihe-in -65.4, 109.6 APE8-rot-in 309.27 APE67-dihe-in -55.68, -21.45 -56.7, -41.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.7538 None None None XRAY 2.0 0.255 0.286 A 321.0 265.0 23 28 16 12 [[62, 321], [418, 675]] 2.0 2z7r Homo sapiens AGC_RPS6KA1-1_HUMAN AGC 1.5e-95 325.1 1.0 260.0 260.0 204 205 206 208 210 94 112 116 184 186 185 187.0 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
AGC RPS6KB1 KS6B1_HUMAN 3A62A P23443 85 372 525.0 STU:400 Type1 Inactive DFGin 6.524 14.1168 ABAminus -137.83, -32.54 -98.98, 101.69 -111.0, 24.18 305.63, 93.27 -75.95, -178.42 in-in in 8.2379 Saltbr-in 2.9117 HRD-in -88.81, -24.52 69.43, -47.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -65.23, -49.64 APE9-dihe-na -102.67, -164.37 APE8-dihe-in -63.46, 142.22 APE8-rot-out 175.82 APE67-dihe-in -68.79, -14.76 -111.61, 8.72 APE12-dist-in 10.2473 APE11-dist-in 13.1357 APE10-dist-out 9.3091 APE9-dist-out 11.6078 None TPO252 TPO252 XRAY 2.35 0.229 0.272 A 327.0 264.0 24 28 18 10 [[91, 352]] 1.0 3a62 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1.0 260.0 260.0 235 236 237 239 241 123 143 147 215 217 216 218.0 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A60A P23443 85 371 525.0 STU:400 Type1 Inactive DFGin 6.1574 13.694 None -106.91, -67.93 -78.35, 124.27 -119.68, -133.11 293.51, 79.75 162.78, -54.12 in-out in 7.7541 Saltbr-out 3.9045 HRD-in -63.83, -43.18 73.78, -30.83 out-out-none SNCoon out-none ActLoopNT-out 3.673 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -74.9 APE8-rot-in 297.46 APE67-dihe-in -54.54, -22.69 -86.47, -11.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.21 0.268 A 327.0 263.0 24 28 15 13 [[91, 352]] 1.0 3a60 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1.0 260.0 260.0 235 236 237 239 241 123 143 147 215 217 216 218.0 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A61A P23443 87 371 525.0 STU:400 Type1 Inactive DFGin 5.8125 13.4055 None -134.05, -75.4 -81.48, 111.28 -98.21, -179.91 302.65, 80.45 -119.91, 999.0 in-in in 7.8631 Saltbr-in 3.4595 HRD-in -91.01, -26.19 64.38, -56.51 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -70.31 APE8-dihe-in -167.04, 106.84 APE8-rot-out 166.31 APE67-dihe-in -54.66, 20.97 -86.85, -22.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9635 None None None XRAY 3.43 0.274 0.349 A 327.0 254.0 31 28 12 16 [[91, 352]] 1.0 3a61 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1.0 260.0 260.0 235 236 237 239 241 123 143 147 215 217 216 218.0 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 4RLOB P23443 85 372 525.0 STU:401 Type1 Inactive None 999.0 7.1958 None -86.75, 160.35 -107.62, 22.98 -156.62, 162.78 69.29, 88.54 159.5, 162.01 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.31, -49.02 69.03, -42.5 none-out-out SNCnoo out-out ActLoopNT-out 4.8155 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 152.17 APE8-rot-out 189.44 APE67-dihe-in -65.44, -8.07 -124.54, 4.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.527 0.193 0.222 B 288.0 254.0 34 28 17 11 [[91, 352]] 1.0 4rlo Homo sapiens AGC_RPS6KB1_HUMAN AGC 2.9e-96 327.5 1.0 260.0 260.0 235 236 237 239 241 123 143 147 215 217 216 218.0 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A60B P23443 85 372 525.0 STU:401 Type1 Inactive None 999.0 9.1812 None -122.3, -155.7 -144.9, 63.43 -46.62, 179.79 231.81, 121.03 -99.91, 37.09 none-none none 999.0 Saltbr-none 999.0 HRD-in -85.46, -48.18 73.35, -54.05 none-in-out SNCnio in-out ActLoopNT-in 2.8646 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -2.69 APE9-dihe-na -82.95, -88.68 APE8-dihe-in -146.72, 128.75 APE8-rot-out 80.81 APE67-dihe-in -72.02, 1.17 -100.99, 0.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 29.7774 APE9-dist-out 31.9666 None None None XRAY 2.8 0.21 0.268 B 327.0 255.0 33 28 18 10 [[91, 352]] 1.0 3a60 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1.0 260.0 260.0 235 236 237 239 241 123 143 147 215 217 216 218.0 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC STK32A ST32A_HUMAN 4FR4A Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 6.9576 14.5496 BLAminus -131.26, -171.36 55.81, 77.24 -91.39, 23.54 282.26, 68.76 -52.72, -37.5 in-out in 9.4495 Saltbr-out 4.4048 HRD-in -80.59, -48.19 75.72, 1.95 out-in-in SNCoii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.54, 125.66 APE9-dihe-na 163.36, -179.6 APE8-dihe-in -98.31, 118.28 APE8-rot-in 302.74 APE67-dihe-in -69.16, -7.09 -58.36, -42.03 APE12-dist-in 9.9839 APE11-dist-in 11.6999 APE10-dist-in 6.0373 APE9-dist-in 3.5766 None None None XRAY 2.29 0.206 0.244 A 384.0 350.0 0 27 27 0 [[23, 281]] 1.0 4fr4 Homo sapiens AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1.0 259.0 259.0 163 164 165 167 169 52 71 75 143 145 144 146.0 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4B Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 7.0038 14.6646 BLAminus -130.94, -173.3 57.57, 78.46 -91.73, 35.47 281.68, 71.64 -62.72, -37.53 in-out in 9.5233 Saltbr-out 4.6779 HRD-in -83.22, -47.99 75.33, -2.43 out-in-in SNCoii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.47, 130.4 APE9-dihe-na 159.4, 177.51 APE8-dihe-in -93.68, 119.81 APE8-rot-in 304.76 APE67-dihe-in -71.88, -7.25 -60.98, -38.06 APE12-dist-in 10.0245 APE11-dist-in 11.735 APE10-dist-in 6.0193 APE9-dist-in 3.5697 None None None XRAY 2.29 0.206 0.244 B 384.0 350.0 0 27 27 0 [[23, 281]] 1.0 4fr4 Homo sapiens AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1.0 259.0 259.0 163 164 165 167 169 52 71 75 143 145 144 146.0 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4C Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 6.9501 14.6971 BLAminus -132.52, -169.93 52.69, 78.95 -90.58, 33.35 282.07, 69.09 -66.67, -30.48 in-out in 9.5382 Saltbr-out 4.6525 HRD-in -81.16, -46.81 73.79, 0.59 out-in-in SNCoii in-in ActLoopNT-in 2.9022 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.08, 126.04 APE9-dihe-na 163.32, 177.32 APE8-dihe-in -92.37, 117.65 APE8-rot-in 306.61 APE67-dihe-in -71.09, -9.62 -57.49, -40.3 APE12-dist-in 9.9861 APE11-dist-in 11.7192 APE10-dist-in 6.0306 APE9-dist-in 3.5686 None None None XRAY 2.29 0.206 0.244 C 384.0 344.0 0 27 27 0 [[23, 281]] 1.0 4fr4 Homo sapiens AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1.0 259.0 259.0 163 164 165 167 169 52 71 75 143 145 144 146.0 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4D Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 6.9681 14.5401 BLAminus -131.99, -171.7 54.78, 77.72 -90.01, 30.97 282.82, 68.36 -59.09, -35.1 in-out in 9.5397 Saltbr-out 4.1113 HRD-in -82.23, -46.79 74.71, 0.05 out-in-in SNCoii in-in ActLoopNT-in 2.9038 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.67, 126.06 APE9-dihe-na 163.38, 179.82 APE8-dihe-in -95.08, 119.14 APE8-rot-in 303.5 APE67-dihe-in -68.68, -8.82 -58.5, -42.47 APE12-dist-in 10.0285 APE11-dist-in 11.6738 APE10-dist-in 5.9782 APE9-dist-in 3.621 None None None XRAY 2.29 0.206 0.244 D 384.0 346.0 0 27 27 0 [[23, 281]] 1.0 4fr4 Homo sapiens AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1.0 259.0 259.0 163 164 165 167 169 52 71 75 143 145 144 146.0 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4E Q8WU08 14 372 396.0 STU:401 Type1 Inactive DFGin 6.9286 14.6895 BLAminus -131.82, -175.27 57.96, 79.76 -93.48, 35.37 282.42, 66.15 -67.02, -30.68 in-out in 9.5587 Saltbr-out 4.6665 HRD-in -80.84, -48.94 74.6, -0.56 out-in-in SNCoii in-in ActLoopNT-in 2.9355 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.84, 126.86 APE9-dihe-na 161.76, 179.6 APE8-dihe-in -94.71, 118.0 APE8-rot-in 302.52 APE67-dihe-in -65.82, -9.98 -56.35, -43.97 APE12-dist-in 10.0325 APE11-dist-in 11.7534 APE10-dist-in 6.0105 APE9-dist-in 3.5549 None None None XRAY 2.29 0.206 0.244 E 384.0 342.0 0 27 27 0 [[23, 281]] 1.0 4fr4 Homo sapiens AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1.0 259.0 259.0 163 164 165 167 169 52 71 75 143 145 144 146.0 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4F Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 6.9223 14.4801 BLAminus -133.24, -172.46 54.73, 79.35 -94.14, 35.98 283.65, 67.48 -61.74, -33.87 in-out in 9.4582 Saltbr-out 4.4586 HRD-in -80.63, -46.14 70.35, 4.86 out-in-in SNCoii in-in ActLoopNT-in 2.8837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.84, 129.22 APE9-dihe-na 160.43, 179.28 APE8-dihe-in -96.01, 118.11 APE8-rot-in 307.21 APE67-dihe-in -68.52, -8.52 -57.81, -41.21 APE12-dist-in 10.0068 APE11-dist-in 11.7034 APE10-dist-in 5.9864 APE9-dist-in 3.5873 None None None XRAY 2.29 0.206 0.244 F 384.0 346.0 0 27 27 0 [[23, 281]] 1.0 4fr4 Homo sapiens AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1.0 259.0 259.0 163 164 165 167 169 52 71 75 143 145 144 146.0 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
CAMK CHEK1 CHK1_HUMAN 1NVRA O14757 3 273 476.0 STU:400 Type1 Active DFGin 7.0073 14.466 BLAminus -138.12, 170.91 63.58, 88.44 -97.82, 26.51 284.37, 82.9 -65.94, -21.37 in-in in 8.8343 Saltbr-in 3.3246 HRD-in -77.73, -42.26 72.42, 0.07 in-in-in SNCiii in-in ActLoopNT-in 2.8923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.96, 168.99 APE9-dihe-na 123.47, -148.6 APE8-dihe-in -135.84, 118.76 APE8-rot-in 301.9 APE67-dihe-in -60.54, -22.99 -38.52, -52.15 APE12-dist-in 8.9865 APE11-dist-in 11.7725 APE10-dist-in 6.2204 APE9-dist-in 3.3435 None None None XRAY 1.8 0.193 0.226 A 289.0 264.0 7 30 30 0 [[9, 265]] 1.0 1nvr Homo sapiens CAMK_CHEK1_HUMAN CAMK 2.6e-71 245.9 2.0 256.0 255.0 147 148 149 151 153 38 55 59 127 129 128 130.0 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7AKOA O14757 2 271 476.0 STU:60301 Type1 Active DFGin 7.2577 14.3463 BLAminus -129.99, 164.38 63.12, 90.57 -95.99, 30.1 286.66, 77.28 -66.31, -26.96 in-in in 8.8335 Saltbr-in 2.687 HRD-in -79.3, -45.9 76.54, 2.66 in-in-in SNCiii in-in ActLoopNT-in 2.9991 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.15, 172.04 APE9-dihe-na 107.34, -156.22 APE8-dihe-in -136.58, 123.75 APE8-rot-in 305.71 APE67-dihe-in -59.04, -20.83 -49.6, -50.22 APE12-dist-in 8.9513 APE11-dist-in 11.9214 APE10-dist-in 6.385 APE9-dist-in 3.5724 D10R None None XRAY 1.8 0.192 0.235 A 300.0 270.0 0 30 30 0 [[9, 265]] 1.0 7ako Homo sapiens CAMK_CHEK1_HUMAN CAMK 3.4e-71 245.5 2.0 256.0 255.0 147 148 149 151 153 38 55 59 127 129 128 130.0 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7AKOB O14757 2 271 476.0 STU:60301 Type1 Active DFGin 7.0372 14.5267 BLAminus -133.06, 166.86 60.65, 91.44 -101.1, 26.21 287.91, 78.35 -62.72, -24.94 in-in in 9.1831 Saltbr-in 3.4036 HRD-in -77.35, -44.25 76.09, 6.63 in-in-in SNCiii in-in ActLoopNT-in 3.0391 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.79, 168.24 APE9-dihe-na 123.14, -149.89 APE8-dihe-in -132.89, 126.1 APE8-rot-in 304.27 APE67-dihe-in -62.82, -10.87 -52.63, -48.98 APE12-dist-in 8.6304 APE11-dist-in 11.8841 APE10-dist-in 6.2467 APE9-dist-in 3.4952 D10R None None XRAY 1.8 0.192 0.235 B 300.0 270.0 0 30 30 0 [[9, 265]] 1.0 7ako Homo sapiens CAMK_CHEK1_HUMAN CAMK 3.4e-71 245.5 2.0 256.0 255.0 147 148 149 151 153 38 55 59 127 129 128 130.0 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5OORA O14757 3 283 476.0 STU:301 Type1 Inactive DFGin 7.1962 13.6031 BLAminus -121.08, 157.07 78.53, 94.76 -101.65, 21.08 291.71, 78.34 -70.5, -20.28 in-out in 9.325 Saltbr-out 5.3808 HRD-in -78.63, -43.76 73.29, -4.94 out-in-in SNCoii in-in ActLoopNT-in 2.9061 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.81, 173.83 APE9-dihe-na 115.52, -146.73 APE8-dihe-in -140.31, 116.76 APE8-rot-in 299.43 APE67-dihe-in -68.59, -17.99 -48.27, -41.97 APE12-dist-in 9.1544 APE11-dist-in 11.7443 APE10-dist-in 6.2959 APE9-dist-in 3.5968 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.9 0.167 0.208 A 297.0 273.0 8 30 30 0 [[9, 265]] 1.0 5oor Homo sapiens CAMK_CHEK1_HUMAN CAMK 4.8e-69 238.4 2.0 256.0 255.0 147 148 149 151 153 38 55 59 127 129 128 130.0 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK DAPK1 DAPK1_HUMAN 1WVYA P53355 4 276 1430.0 STU:1001 Type1 Inactive DFGin 6.7415 14.2933 ABAminus -89.35, -23.12 -108.72, 148.84 -138.39, 21.2 279.12, 93.85 -56.2, -46.66 in-in in 9.4531 Saltbr-in 2.7914 HRD-in -70.14, -42.49 63.36, 7.4 in-in-out SNCiio in-out ActLoopNT-in 2.7569 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -134.32, 148.67 APE9-dihe-na -105.19, -133.62 APE8-dihe-in -62.12, 122.93 APE8-rot-in 303.72 APE67-dihe-in -56.52, -27.75 -50.01, -41.98 APE12-dist-in 10.3491 APE11-dist-out 5.638 APE10-dist-out 8.7625 APE9-dist-in 4.9739 None None None XRAY 2.8 0.222 0.274 A 278.0 273.0 0 27 27 0 [[13, 275]] 1.0 1wvy Homo sapiens CAMK_DAPK1_HUMAN CAMK 5e-95 323.6 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK MAPKAPK2 MAPK2_HUMAN 2PZYC P49137 42 359 400.0 STU:3 Type1 None DFGin 4.7421 13.5838 BLAminus -137.32, 155.33 89.76, 83.85 -93.67, 22.39 287.9, 52.26 -71.67, 3.21 in-in in 8.8993 Saltbr-in 2.4787 HRD-in -82.26, -44.82 71.63, -15.61 in-in-none SNCiin in-none ActLoopNT-in 2.8228 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -81.01, -7.47 999.0, -140.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.251 0.313 C 324.0 307.0 11 27 16 11 [[63, 325]] 1.0 2pzy Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3.0 256.0 254.0 206 207 208 210 212 93 104 108 183 185 184 186.0 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKA P49137 42 345 400.0 STU:401 Type1 None DFGin 4.8289 13.4276 BLAminus -122.05, -170.73 42.15, 101.84 -103.58, 19.28 282.18, 65.24 -58.03, -23.15 in-in in 8.7159 Saltbr-in 2.4725 HRD-in -79.4, -39.47 62.13, 0.83 in-in-none SNCiin in-none ActLoopNT-in 2.6831 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -71.16, 3.04 999.0, 148.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 A 400.0 290.0 14 27 16 11 [[63, 325]] 1.0 1nxk Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3.0 256.0 254.0 206 207 208 210 212 93 104 108 183 185 184 186.0 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKB P49137 44 345 400.0 STU:403 Type1 None DFGin 4.5769 13.8216 BLAminus -128.27, 177.79 53.09, 103.0 -104.87, 20.3 276.49, 67.38 -57.0, -14.43 in-in in 8.6474 Saltbr-in 2.5635 HRD-in -64.22, -46.2 66.47, 1.25 in-in-none SNCiin in-none ActLoopNT-in 2.8195 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.0, -19.87 999.0, 111.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 B 400.0 283.0 19 27 16 11 [[63, 325]] 1.0 1nxk Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3.0 256.0 254.0 206 207 208 210 212 93 104 108 183 185 184 186.0 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKC P49137 41 357 400.0 STU:401 Type1 None DFGin 4.9628 13.774 BLAminus -132.89, 178.15 57.47, 93.76 -100.34, 25.49 283.43, 65.32 -70.88, 11.4 in-in in 8.6843 Saltbr-in 2.3398 HRD-in -75.36, -47.72 65.17, 8.17 in-in-none SNCiin in-none ActLoopNT-in 2.9819 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.28, 2.34 999.0, 115.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 C 400.0 306.0 11 27 16 11 [[63, 325]] 1.0 1nxk Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3.0 256.0 254.0 206 207 208 210 212 93 104 108 183 185 184 186.0 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKD P49137 43 342 400.0 STU:401 Type1 Inactive DFGin 4.8314 13.91 BLAminus -136.01, 172.45 58.97, 96.18 -97.02, 30.62 280.59, 64.96 -55.97, -37.81 in-in in 8.8025 Saltbr-in 2.6493 HRD-in -61.55, -54.52 76.31, -8.43 in-in-out SNCiio in-out ActLoopNT-in 3.0037 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, 21.79 APE9-dihe-na -95.93, -89.71 APE8-dihe-out 87.4, 89.72 APE8-rot-in 304.66 APE67-dihe-out -57.06, -12.13 -63.98, 136.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 30.4871 APE9-dist-out 33.3307 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 D 400.0 288.0 12 27 19 8 [[63, 325]] 1.0 1nxk Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3.0 256.0 254.0 206 207 208 210 212 93 104 108 183 185 184 186.0 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MKNK2 MKNK2_HUMAN 2HW7A Q9HBH9 72 371 465.0 STU:60031 Type1 Inactive DFGin 4.9051 14.1234 BLBplus -153.19, 172.78 68.05, 27.15 -77.7, 175.81 23.89, 67.82 81.52, 999.0 in-in in 8.9926 Saltbr-in 2.9032 HRD-in -73.6, -55.95 77.37, -18.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 26.54 APE8-dihe-out -84.42, -14.4 APE8-rot-in 301.04 APE67-dihe-in -61.16, -21.76 -49.65, -47.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 33.4696 D228G None None XRAY 2.71 0.203 0.246 A 316.0 269.0 31 35 12 23 [[83, 368]] 1.0 2hw7 Homo sapiens CAMK_MKNK2_HUMAN CAMK 8e-79 270.5 1.0 256.0 256.0 225 226 227 229 231 113 129 133 202 204 203 205.0 277 260 255 254 253 252 251 250 249 160 MAP kinase-interacting serine/threonine-protein kinase 2
CAMK PIM1 PIM1_HUMAN 1YHSA P11309 33 305 313.0 STU:306 Type1 Active DFGin 6.3607 14.5116 BLAminus -129.35, 165.16 65.09, 87.92 -99.2, 21.71 283.47, 69.45 -67.38, -11.76 in-in in 8.5242 Saltbr-in 2.8992 HRD-naA -65.05, -49.56 68.79, 3.6 in-in-in SNCiii in-in ActLoopNT-in 2.9031 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.4, 26.1 APE9-dihe-na -84.03, -156.82 APE8-dihe-in -85.78, 122.63 APE8-rot-in 304.34 APE67-dihe-in -62.69, -6.01 -56.85, -49.38 APE12-dist-in 9.327 APE11-dist-in 8.5203 APE10-dist-in 5.5084 APE9-dist-in 3.8321 None SEP261 CME161,SEP261 XRAY 2.15 0.233 0.233 A 273.0 269.0 4 26 26 0 [[38, 290]] 1.0 1yhs Homo sapiens CAMK_PIM1_HUMAN CAMK 2.4e-65 226.3 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PRKAA1 AAPK1_HUMAN 6C9FA Q13131 22 558 559.0 R34:60601,STU:60602 Allosteric,Type1 Inactive DFGin 6.7283 14.2948 ABAminus -116.49, -61.55 -94.26, 110.71 -99.52, 6.4 287.66, 85.72 -50.13, -39.13 out-out out 10.7128 Saltbr-out 5.3185 HRD-in -66.33, -58.11 53.99, 16.31 out-in-out SNCoio in-out ActLoopNT-in 2.7714 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.89, 155.28 APE9-dihe-na 94.11, 171.31 APE8-dihe-in -69.7, 144.51 APE8-rot-out 175.9 APE67-dihe-in -64.59, -37.19 -54.17, -35.84 APE12-dist-in 8.2675 APE11-dist-in 10.7302 APE10-dist-in 5.1485 APE9-dist-in 4.2372 None TPO183 TPO183 XRAY 2.924 0.229 0.245 A 494.0 371.0 0 27 27 0 [[27, 279]] 1.0 6c9f Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 6C9GA Q13131 22 558 559.0 R93:60601,STU:60602 Allosteric,Type1 Inactive DFGin 6.9066 14.3995 BLAminus -135.02, 170.21 60.34, 77.63 -85.45, 11.43 285.05, 75.57 -50.8, -32.37 out-out out 10.6954 Saltbr-out 5.5967 HRD-in -79.11, -48.44 68.49, -16.14 out-in-out SNCoio in-out ActLoopNT-in 2.8772 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -145.15, 158.83 APE9-dihe-na 72.57, 174.42 APE8-dihe-in -69.04, 143.86 APE8-rot-out 162.73 APE67-dihe-in -62.81, -32.14 -55.18, -38.62 APE12-dist-in 8.4498 APE11-dist-in 11.0313 APE10-dist-in 6.0082 APE9-dist-in 4.0093 None TPO183 TPO183 XRAY 2.7 0.205 0.24 A 494.0 384.0 0 27 27 0 [[27, 279]] 1.0 6c9g Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 6C9HA Q13131 22 558 559.0 R34:60601,STU:60602 Allosteric,Type1 Inactive DFGin 6.7117 14.3818 BLAminus -138.26, 171.2 60.5, 73.75 -84.01, 6.76 285.61, 85.73 -48.49, -36.53 out-out out 10.6488 Saltbr-out 5.6307 HRD-in -69.22, -48.97 68.92, -5.29 out-in-out SNCoio in-out ActLoopNT-in 3.017 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -142.6, 158.62 APE9-dihe-na 60.32, -132.0 APE8-dihe-in -130.57, 153.41 APE8-rot-out 177.79 APE67-dihe-in -63.0, -34.49 -63.07, -41.05 APE12-dist-in 8.6555 APE11-dist-in 10.6184 APE10-dist-in 6.1892 APE9-dist-in 3.8729 None None None XRAY 2.65 0.215 0.242 A 494.0 433.0 0 27 27 0 [[27, 279]] 1.0 6c9h Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 6C9JA Q13131 22 559 559.0 R34:60601,STU:60602 Allosteric,Type1 Active DFGin 6.9799 13.9321 BLAminus -148.31, -179.86 61.68, 68.06 -82.96, 8.26 285.07, 89.54 -49.65, -37.12 out-in out 10.0503 Saltbr-in 3.0249 HRD-in -61.18, -61.45 68.18, -7.34 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.03, 155.55 APE9-dihe-na 81.79, 170.06 APE8-dihe-in -65.93, 140.22 APE8-rot-in 298.24 APE67-dihe-in -65.83, -31.14 -52.06, -38.38 APE12-dist-in 8.3121 APE11-dist-in 11.1991 APE10-dist-in 5.6399 APE9-dist-in 4.1005 None TPO183 TPO183 XRAY 3.05 0.215 0.225 A 494.0 384.0 0 27 27 0 [[27, 279]] 1.0 6c9j Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 4RERA Q13131 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.7243 14.6822 None -104.41, -74.44 -70.58, 123.21 -111.45, 7.12 271.34, 95.59 -64.34, -25.66 in-in in 9.3938 Saltbr-in 3.1678 HRD-out -106.73, 104.09 -76.93, -37.65 in-in-in SNCiii in-in ActLoopNT-in 2.9275 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.23, 162.43 APE9-dihe-na 109.76, -176.61 APE8-dihe-in -65.38, 159.16 APE8-rot-in 282.67 APE67-dihe-in -82.84, -28.7 -67.98, -40.26 APE12-dist-in 8.7645 APE11-dist-in 11.1018 APE10-dist-in 5.3529 APE9-dist-in 4.5655 E480G,E483A,K485A TPO183 TPO183 XRAY 4.047 0.227 0.26 A 540.0 459.0 0 27 27 0 [[27, 279]] 1.0 4rer Homo sapiens CAMK_PRKAA1_HUMAN CAMK 8.5e-89 303.4 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 4REWA Q13131 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.2816 14.4447 None -106.98, -78.3 -79.98, 116.66 -98.66, 4.74 266.69, 106.69 -52.57, -49.44 out-out out 10.8944 Saltbr-out 4.8489 HRD-out -91.4, 104.28 -79.59, -35.51 out-in-out SNCoio in-out ActLoopNT-in 2.9485 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -146.3, 177.71 APE9-dihe-na 92.22, 179.97 APE8-dihe-in -62.77, 176.84 APE8-rot-in 309.53 APE67-dihe-in -79.73, -37.36 -85.43, -26.86 APE12-dist-in 9.0318 APE11-dist-in 10.9116 APE10-dist-in 6.0735 APE9-dist-out 7.1663 E480G,E483A,K485A None None XRAY 4.58 0.234 0.259 A 540.0 411.0 0 27 27 0 [[27, 279]] 1.0 4rew Homo sapiens CAMK_PRKAA1_HUMAN CAMK 8.5e-89 303.4 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA2 AAPK2_HUMAN 5ISOA P54646 9 551 552.0 STU:601,992:602 Type1,Allosteric Inactive DFGin 7.0764 13.7542 ABAminus -124.01, -69.61 -91.71, 113.8 -98.34, 8.3 284.02, 83.8 -52.09, -32.8 out-none out 10.6758 Saltbr-none 999.0 HRD-in -77.82, -48.64 73.79, -15.56 none-in-out SNCnio in-out ActLoopNT-in 3.0698 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -153.96, 161.46 APE9-dihe-na 108.89, 175.81 APE8-dihe-in -73.92, 127.97 APE8-rot-out 47.66 APE67-dihe-in -62.08, -29.52 -54.52, -36.25 APE12-dist-in 8.114 APE11-dist-in 11.3548 APE10-dist-in 6.5955 APE9-dist-in 5.0387 None None None XRAY 2.63 0.18 0.23 A 552.0 453.0 0 27 27 0 [[16, 268]] 1.0 5iso Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.1e-89 306.3 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5ISOC P54646 9 550 552.0 STU:601,992:602 Type1,Allosteric Inactive DFGin 7.1851 14.12 ABAminus -118.95, -64.95 -97.93, 114.29 -100.77, 6.08 282.8, 83.31 -57.51, -20.09 out-none out 10.9206 Saltbr-none 999.0 HRD-in -73.97, -50.71 73.94, -15.38 none-in-out SNCnio in-out ActLoopNT-in 3.0258 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.17, 145.11 APE9-dihe-na 105.06, -178.93 APE8-dihe-in -75.45, 134.7 APE8-rot-out 182.56 APE67-dihe-in -57.91, -29.21 -54.57, -40.7 APE12-dist-in 9.0148 APE11-dist-in 11.2229 APE10-dist-in 5.4236 APE9-dist-in 4.3015 None None None XRAY 2.63 0.18 0.23 C 552.0 429.0 0 27 27 0 [[16, 268]] 1.0 5iso Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.1e-89 306.3 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 6B1UC P54646 9 552 552.0 STU:60601,CG7:60602 Type1,Allosteric Inactive DFGin 7.4516 14.1299 ABAminus -133.95, -50.46 -79.36, 100.93 -96.81, 22.67 283.51, 87.03 -67.96, -35.6 out-out out 10.2466 Saltbr-out 4.344 HRD-in -62.69, -52.12 64.78, 6.12 out-in-out SNCoio in-out ActLoopNT-in 3.0313 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 59.85, -130.04 APE9-dihe-na -84.76, -170.01 APE8-dihe-in -60.51, 139.79 APE8-rot-out 157.81 APE67-dihe-in -64.49, -24.93 -66.94, -29.94 APE12-dist-in 7.802 APE11-dist-in 10.1021 APE10-dist-in 6.0757 APE9-dist-in 4.4225 None TPO172 TPO172 XRAY 2.77 0.196 0.226 C 565.0 460.0 0 27 27 0 [[16, 268]] 1.0 6b1u Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFFA P54646 8 551 552.0 STU:61552 Type1 Inactive DFGin 7.0564 14.0818 BLAminus -149.77, 179.95 57.3, 81.92 -95.29, 37.99 289.6, 92.87 -75.43, -19.2 out-out out 10.9893 Saltbr-out 5.616 HRD-out -79.02, 102.38 -90.23, 5.49 out-in-out SNCoio in-out ActLoopNT-in 3.1062 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -140.4, 154.3 APE9-dihe-na 120.73, -179.28 APE8-dihe-in -68.72, 155.02 APE8-rot-out 179.49 APE67-dihe-out -92.39, 175.4 -57.6, -33.75 APE12-dist-in 7.9516 APE11-dist-in 11.1768 APE10-dist-in 5.5536 APE9-dist-in 3.902 None TPO172 TPO172 XRAY 3.924 0.211 0.264 A 571.0 425.0 0 27 27 0 [[16, 268]] 1.0 4cff Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 8BIKA P54646 8 551 552.0 STU:61001,QTN:61002 Type1,Allosteric Inactive DFGin 7.4108 14.1375 BLAminus -139.87, 175.04 60.92, 88.41 -94.92, 18.04 278.75, 87.35 -59.01, -34.32 out-in out 10.1739 Saltbr-in 2.8766 HRD-in -67.48, -51.05 72.2, -5.59 in-in-out SNCiio in-out ActLoopNT-in 3.0285 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.52, 150.63 APE9-dihe-na 107.16, 178.8 APE8-dihe-in -62.54, 134.22 APE8-rot-out 175.32 APE67-dihe-in -59.81, -28.17 -63.52, -36.76 APE12-dist-in 7.7788 APE11-dist-in 11.4392 APE10-dist-in 5.7681 APE9-dist-in 4.246 None None None XRAY 2.5 0.183 0.215 A 559.0 451.0 0 27 27 0 [[16, 268]] 1.0 8bik Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 8BIKD P54646 9 551 552.0 STU:61001,QTN:61002 Type1,Allosteric Inactive DFGin 7.384 14.4446 BLAminus -141.24, 172.63 63.28, 83.56 -89.35, 21.67 278.42, 85.15 -58.54, -35.7 out-in out 10.1752 Saltbr-in 2.8052 HRD-in -67.72, -52.05 72.56, -5.24 in-in-out SNCiio in-out ActLoopNT-in 3.0392 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -138.07, 151.38 APE9-dihe-na 109.6, 178.13 APE8-dihe-in -63.22, 133.31 APE8-rot-out 174.24 APE67-dihe-in -63.88, -27.23 -63.0, -33.55 APE12-dist-in 7.8083 APE11-dist-in 11.3382 APE10-dist-in 5.6939 APE9-dist-in 4.2241 None None None XRAY 2.5 0.183 0.215 D 559.0 443.0 0 27 27 0 [[16, 268]] 1.0 8bik Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 6B2EA P54646 9 551 552.0 STU:60601,CG7:60602 Type1,Allosteric Inactive DFGin 6.8359 14.6749 BLAminus -127.75, -179.24 60.25, 73.12 -88.18, 14.06 273.69, 88.23 -67.6, -15.67 out-none out 10.0019 Saltbr-none 999.0 HRD-out -78.51, 91.55 -68.49, -19.81 none-in-out SNCnio in-out ActLoopNT-in 3.1235 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiio APE10-dihe-na -70.16, 148.6 APE9-dihe-na -63.35, -41.66 APE8-dihe-in -61.85, 118.31 APE8-rot-out 58.89 APE67-dihe-out -81.11, 165.06 -67.04, -35.27 APE12-dist-in 8.4672 APE11-dist-in 10.8 APE10-dist-in 6.9386 APE9-dist-out 8.497 None TPO172 TPO172 XRAY 3.8 0.246 0.277 A 565.0 443.0 0 27 27 0 [[16, 268]] 1.0 6b2e Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFEA P54646 8 551 552.0 STU:61552,992:61553 Type1,Allosteric Inactive DFGin 7.0796 14.0721 BLAminus -145.68, 179.18 60.7, 83.63 -96.97, 26.73 284.08, 87.71 -65.51, -24.73 out-out out 10.7276 Saltbr-out 5.3537 HRD-out -86.27, 102.77 -89.89, 0.95 out-in-out SNCoio in-out ActLoopNT-in 3.1121 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -129.79, 163.12 APE9-dihe-na 115.46, -178.56 APE8-dihe-in -67.55, 156.43 APE8-rot-out 179.35 APE67-dihe-out -75.24, 179.33 -55.61, -52.75 APE12-dist-in 7.8317 APE11-dist-in 11.1822 APE10-dist-in 5.5022 APE9-dist-in 4.035 None TPO172 TPO172 XRAY 3.023 0.219 0.253 A 571.0 426.0 0 27 27 0 [[16, 268]] 1.0 4cfe Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFEC P54646 10 551 552.0 STU:61552,992:61553 Type1,Allosteric Inactive DFGin 6.7879 14.041 BLAminus -149.49, 177.86 54.08, 78.43 -74.33, -60.5 283.52, 75.88 44.88, -65.29 out-out out 10.8275 Saltbr-out 5.2457 HRD-out -83.19, 107.96 -92.05, 0.22 out-in-out SNCoio in-out ActLoopNT-in 2.9738 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -138.71, 159.05 APE9-dihe-na 117.28, 177.67 APE8-dihe-in -66.82, 154.33 APE8-rot-out 184.3 APE67-dihe-out -85.99, 172.12 -55.69, -41.12 APE12-dist-in 7.7099 APE11-dist-in 11.0432 APE10-dist-in 5.4181 APE9-dist-in 4.2153 None TPO172 TPO172 XRAY 3.023 0.219 0.253 C 571.0 404.0 0 27 27 0 [[16, 268]] 1.0 4cfe Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5EZVA P54646 8 551 552.0 STU:60601,C1V:60602 Type1,Allosteric Inactive DFGin 7.2674 14.6333 None -121.03, -63.06 -68.65, 101.9 -100.19, 25.35 279.34, 91.81 -68.17, -44.69 in-in in 9.8608 Saltbr-in 2.6899 HRD-in -59.46, -47.11 63.8, -4.14 in-in-in SNCiii in-in ActLoopNT-in 3.0028 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.63, 144.51 APE9-dihe-na 86.66, 177.12 APE8-dihe-in -64.88, 140.75 APE8-rot-in 312.82 APE67-dihe-in -66.61, -22.38 -58.4, -32.39 APE12-dist-in 7.7539 APE11-dist-in 10.4368 APE10-dist-in 5.1306 APE9-dist-in 4.4026 None TPO172 TPO172 XRAY 2.99 0.225 0.245 A 560.0 433.0 0 27 27 0 [[16, 268]] 1.0 5ezv Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5EZVC P54646 9 551 552.0 STU:60601,C1V:60602 Type1,Allosteric Inactive DFGin 7.4323 14.3494 None -121.9, -67.2 -69.32, 103.91 -104.03, 30.29 280.2, 90.51 -70.5, -44.85 out-in out 10.4146 Saltbr-in 3.2079 HRD-in -65.9, -50.28 64.78, -4.1 in-in-out SNCiio in-out ActLoopNT-in 2.9393 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.83, 151.12 APE9-dihe-na 88.46, 177.26 APE8-dihe-in -64.21, 140.09 APE8-rot-out 194.68 APE67-dihe-in -65.12, -32.21 -57.93, -31.87 APE12-dist-in 7.8362 APE11-dist-in 10.5358 APE10-dist-in 5.1127 APE9-dist-in 4.4856 None TPO172 TPO172 XRAY 2.99 0.225 0.245 C 560.0 434.0 0 27 27 0 [[16, 268]] 1.0 5ezv Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 6B1UA P54646 8 550 552.0 STU:60601,CG7:60602 Type1,Allosteric Inactive DFGin 7.2691 14.4408 None -129.47, -55.38 -79.75, 100.47 -94.16, 25.18 281.88, 87.91 -69.36, -38.1 out-in out 10.0903 Saltbr-in 2.8061 HRD-in -70.7, -48.35 62.09, 8.12 in-in-out SNCiio in-out ActLoopNT-in 3.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -119.71, 141.45 APE9-dihe-na 98.59, 173.56 APE8-dihe-in -72.38, 142.58 APE8-rot-out 181.03 APE67-dihe-in -62.9, -27.33 -58.67, -32.16 APE12-dist-in 7.9718 APE11-dist-in 10.5218 APE10-dist-in 4.9765 APE9-dist-in 3.8757 None TPO172 TPO172 XRAY 2.77 0.196 0.226 A 565.0 442.0 0 27 27 0 [[16, 268]] 1.0 6b1u Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFFC P54646 10 551 552.0 STU:61552,C1V:61553 Type1,Allosteric Inactive DFGin 6.7813 14.0798 None -150.62, -172.52 53.67, 68.27 -65.24, -76.3 281.99, 78.69 54.48, -69.27 out-out out 10.8955 Saltbr-out 5.3095 HRD-out -84.81, 105.73 -92.0, 12.06 out-in-out SNCoio in-out ActLoopNT-in 3.0342 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -122.19, 170.3 APE9-dihe-na 112.32, 178.27 APE8-dihe-in -67.95, 156.54 APE8-rot-out 180.36 APE67-dihe-out -82.42, 177.62 -55.27, -42.84 APE12-dist-in 7.7542 APE11-dist-in 11.1374 APE10-dist-in 5.4326 APE9-dist-in 3.967 None TPO172 TPO172 XRAY 3.924 0.211 0.264 C 571.0 423.0 0 27 27 0 [[16, 268]] 1.0 4cff Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CMGC CDK2 CDK2_HUMAN 4ERWA P24941 1 298 298.0 STU:301 Type1 Inactive DFGin 8.1617 15.6021 BLBminus -125.29, 160.66 52.47, 61.82 -60.63, 138.56 279.12, 65.63 -74.82, 135.35 out-out out 15.4669 Saltbr-out 12.0237 HRD-in -85.09, -48.23 77.57, -22.2 out-out-out SNCooo out-out ActLoopNT-out 9.2791 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -82.87, 148.53 APE9-dihe-na -96.15, 140.05 APE8-dihe-in -88.42, 131.99 APE8-rot-out 198.97 APE67-dihe-in -59.72, -24.59 -102.21, -6.98 APE12-dist-out 19.529 APE11-dist-out 16.2582 APE10-dist-out 18.6866 APE9-dist-out 10.8972 None None OCS177 XRAY 2.0 0.196 0.244 A 306.0 293.0 5 28 28 0 [[4, 286]] 1.0 4erw Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EZ7A P24941 1 298 298.0 STU:60301,2AN:60302,2AN:60303 Type1,Type3,Allosteric Inactive DFGin 6.9781 14.6249 BLBminus -145.53, 170.39 52.9, 57.73 -61.57, 149.9 287.28, 68.06 -86.96, 168.33 out-out out 16.748 Saltbr-out 14.4128 HRD-in -86.07, -42.21 71.45, -15.9 out-out-out SNCooo out-out ActLoopNT-out 10.2365 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -63.47, 156.15 APE9-dihe-na -125.23, 14.23 APE8-dihe-out -63.17, -28.79 APE8-rot-in 293.42 APE67-dihe-in -53.71, -31.99 -57.23, -35.61 APE12-dist-out 18.4717 APE11-dist-out 18.425 APE10-dist-out 13.9772 APE9-dist-out 11.3055 None None None XRAY 2.49 0.22 0.274 A 306.0 298.0 0 28 28 0 [[4, 286]] 1.0 4ez7 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1AQ1A P24941 1 298 298.0 STU:299 Type1 Inactive DFGin 7.2826 14.9343 BLBplus -138.32, 166.15 50.99, 60.93 -140.99, 149.68 67.4, 106.52 86.86, 1.1 out-out out 14.8878 Saltbr-out 13.1715 HRD-in -84.88, -53.74 82.51, -14.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -59.57, 119.45 APE9-dihe-na -86.87, 141.05 APE8-dihe-in -59.86, 138.54 APE8-rot-out 207.57 APE67-dihe-in -54.1, -30.89 -108.21, -4.5 APE12-dist-none 999.0 APE11-dist-out 16.3195 APE10-dist-out 19.1238 APE9-dist-out 10.6767 None None None XRAY 2.0 0.22 0.26 A 298.0 277.0 21 28 15 13 [[4, 286]] 1.0 1aq1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7NVQA P24941 1 294 298.0 STU:301 Type1 Inactive DFGin 7.0261 14.7007 BLBplus -138.98, 166.91 60.92, 69.03 -161.06, 162.59 72.07, 108.19 128.48, -14.92 out-out out 14.3509 Saltbr-out 15.1658 HRD-in -80.38, -55.15 83.91, -13.55 out-out-out SNCooo out-out ActLoopNT-out 6.0294 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.14, 127.57 APE9-dihe-na -77.4, 113.59 APE8-dihe-in -55.3, 141.9 APE8-rot-out 195.1 APE67-dihe-in -55.26, -27.26 -100.43, -4.92 APE12-dist-out 18.864 APE11-dist-out 17.7027 APE10-dist-out 18.9757 APE9-dist-out 9.8903 None None None XRAY 2.05 0.24 0.288 A 300.0 287.0 7 28 28 0 [[4, 286]] 1.0 7nvq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC GSK3B GSK3B_HUMAN 1Q3DA P49841 35 385 420.0 STU:451 Type1 Active DFGin 7.2063 14.4113 BLAminus -139.48, 178.33 63.94, 87.17 -99.43, 23.77 282.58, 69.4 -66.25, -14.58 in-in in 8.701 Saltbr-in 2.8552 HRD-in -65.74, -44.7 66.01, 11.52 in-in-in SNCiii in-in ActLoopNT-in 3.0363 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -94.53, 169.72 APE9-dihe-na 81.56, 143.56 APE8-dihe-in -91.54, 154.32 APE8-rot-in 294.67 APE67-dihe-inflip 96.36, -28.56 -51.12, 132.48 APE12-dist-in 13.0736 APE11-dist-in 11.1082 APE10-dist-in 6.0869 APE9-dist-in 3.274 None None None XRAY 2.2 0.23 0.252 A 424.0 339.0 12 27 27 0 [[56, 340]] 1.0 1q3d Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1Q3DB P49841 35 383 420.0 STU:452 Type1 Active DFGin 7.26 14.4195 BLAminus -137.95, 177.39 64.41, 87.07 -97.99, 22.53 282.7, 70.11 -63.96, -17.29 in-in in 8.7081 Saltbr-in 2.9721 HRD-in -67.72, -45.35 66.86, 12.1 in-in-in SNCiii in-in ActLoopNT-in 3.0238 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -93.75, 170.28 APE9-dihe-na 79.08, 144.81 APE8-dihe-in -89.94, 151.95 APE8-rot-in 299.26 APE67-dihe-inflip 101.61, -31.22 -54.51, 132.99 APE12-dist-in 13.0847 APE11-dist-in 11.0881 APE10-dist-in 6.1457 APE9-dist-in 3.2379 None None None XRAY 2.2 0.23 0.252 B 424.0 339.0 10 27 27 0 [[56, 340]] 1.0 1q3d Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
OTHER ERN1 ERN1_HUMAN 4YZCA O75460 562 963 977.0 STU:1001 Type1 None DFGin 4.5402 13.5982 BLAminus -149.66, -173.45 57.49, 66.53 -77.65, -2.16 287.89, 65.87 -48.01, -38.7 in-none in 9.3632 Saltbr-none 999.0 HRD-in -69.99, -44.37 70.23, -12.54 none-in-in SNCnii in-in ActLoopNT-in 2.8966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -68.95, 160.8 APE9-dihe-na 106.7, 168.85 APE8-dihe-in -105.56, 142.33 APE8-rot-in 309.63 APE67-dihe-inflip 90.78, -21.58 -55.3, 131.97 APE12-dist-in 10.4006 APE11-dist-in 11.3276 APE10-dist-in 5.4058 APE9-dist-in 3.6014 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.494 0.249 0.289 A 405.0 385.0 17 31 30 1 [[571, 832]] 1.0 4yzc Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZCB O75460 562 963 977.0 STU:1001 Type1 None DFGin 4.3622 13.613 BLAminus -140.88, -173.22 59.3, 72.64 -84.99, 5.45 286.37, 62.28 -53.44, -38.69 in-none in 9.6084 Saltbr-none 999.0 HRD-in -70.83, -44.64 74.46, -16.49 none-in-in SNCnii in-in ActLoopNT-in 2.9715 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -78.48, 164.52 APE9-dihe-na 106.87, 177.31 APE8-dihe-in -111.04, 139.81 APE8-rot-in 310.36 APE67-dihe-inflip 90.66, -20.76 -52.98, 131.15 APE12-dist-in 10.8362 APE11-dist-in 11.2328 APE10-dist-in 5.3941 APE9-dist-in 3.6931 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.494 0.249 0.289 B 405.0 384.0 18 31 29 2 [[571, 832]] 1.0 4yzc Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER STK16 STK16_HUMAN 2BUJA O75716 13 299 305.0 STU:61301,STU:61302 Type1,Allosteric Active DFGin 5.2885 13.0033 BLAminus -135.89, -178.46 61.93, 77.23 -105.11, 26.12 316.44, 178.21 -83.9, 1.31 in-in in 9.0243 Saltbr-in 2.9892 HRD-in -74.11, -51.49 80.14, -8.2 in-in-in SNCiii in-in ActLoopNT-in 2.9713 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.51, -7.91 APE9-dihe-na -119.57, 103.56 APE8-dihe-in -42.23, 126.34 APE8-rot-in 303.64 APE67-dihe-in -75.83, -5.68 -58.31, -41.55 APE12-dist-in 12.9195 APE11-dist-in 9.1773 APE10-dist-in 4.9411 APE9-dist-in 4.0001 R19H,R266W None None XRAY 2.6 0.187 0.229 A 317.0 283.0 4 37 37 0 [[20, 292]] 1.0 2buj Homo sapiens OTHER_STK16_HUMAN OTHER 4.7e-40 143.7 1.0 258.0 258.0 165 166 167 169 171 49 65 69 145 147 146 148.0 217 202 197 196 195 194 193 192 191 99 Serine/threonine-protein kinase 16
OTHER STK16 STK16_HUMAN 2BUJB O75716 13 297 305.0 STU:61299,STU:61300 Type1,Type1 Active DFGin 5.4737 13.4932 BLAminus -129.22, -175.67 64.04, 67.15 -107.31, -12.83 320.05, 164.52 -59.54, -39.15 in-in in 8.9475 Saltbr-in 2.3744 HRD-in -61.68, -60.28 75.79, -4.77 in-in-in SNCiii in-in ActLoopNT-in 3.1971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.51, -36.93 APE9-dihe-na -101.29, 104.25 APE8-dihe-in -41.65, 126.41 APE8-rot-in 314.22 APE67-dihe-in -74.19, -9.63 -59.55, -34.23 APE12-dist-in 13.9482 APE11-dist-in 10.1855 APE10-dist-in 6.5377 APE9-dist-in 3.6972 R19H,R266W None None XRAY 2.6 0.187 0.229 B 317.0 277.0 8 37 37 0 [[20, 292]] 1.0 2buj Homo sapiens OTHER_STK16_HUMAN OTHER 4.7e-40 143.7 1.0 258.0 258.0 165 166 167 169 171 49 65 69 145 147 146 148.0 217 202 197 196 195 194 193 192 191 99 Serine/threonine-protein kinase 16
OTHER TTK TTK_HUMAN 3HMOA P33981 514 794 857.0 STU:1 Type1 Inactive DFGin 4.0338 15.2785 ABAminus -96.9, -14.35 -154.28, 164.59 -116.14, 11.51 302.21, 156.99 70.91, 11.96 out-out out 11.1476 Saltbr-out 6.638 HRD-in -61.3, -53.03 75.35, 1.42 out-out-out SNCooo out-out ActLoopNT-out 11.6803 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -169.39 APE9-dihe-na 94.05, 108.89 APE8-dihe-in -96.62, 156.5 APE8-rot-out 54.19 APE67-dihe-in -64.02, -25.79 -101.71, 14.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.1227 APE9-dist-out 11.5633 None None None XRAY 2.4 0.217 0.261 A 342.0 257.0 24 30 18 12 [[525, 791]] 1.0 3hmo Homo sapiens OTHER_TTK_HUMAN CAMK 1.1e-53 188.1 1.0 256.0 256.0 663 664 665 667 669 553 571 575 644 646 645 647.0 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
STE MAP2K6 MP2K6_HUMAN 3FMEA P52564 47 333 334.0 STU:60001 Type1 Inactive None 999.0 999.0 None -108.01, 128.57 -82.08, 37.27 -74.9, 999.0 999.0, 999.0 999.0, 999.0 out-na out 16.0922 Saltbr-na 15.2311 HRD-in -57.54, -47.19 80.18, -0.06 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_nnno APE10-dihe-na 999.0, 108.95 APE9-dihe-na -76.08, 66.3 APE8-dihe-in -91.33, 156.42 APE8-rot-na 298.81 APE67-dihe-out -82.0, 103.94 -93.42, 147.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.9762 S207D,T211D None None XRAY 2.26 0.213 0.236 A 290.0 267.0 20 27 12 15 [[53, 314]] 1.0 3fme Homo sapiens STE_MAP2K6_HUMAN STE 3.8e-85 291.3 3.0 257.0 255.0 196 197 198 200 202 82 99 103 176 178 177 179.0 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
STE MAP3K5 M3K5_HUMAN 4BF2A Q99683 671 939 1374.0 STU:1940 Type1 Inactive DFGin 7.2126 13.8075 BLAminus -114.3, -178.78 51.44, 86.67 -90.54, 15.85 294.66, 96.8 -75.78, -2.2 out-none out 10.049 Saltbr-none 999.0 HRD-in -67.79, -49.78 78.33, -4.9 none-in-out SNCnio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -128.2, 134.23 APE9-dihe-na -68.74, -169.24 APE8-dihe-in -70.38, 133.03 APE8-rot-in 304.95 APE67-dihe-in -66.2, -12.84 -50.6, -52.99 APE12-dist-in 11.0591 APE11-dist-out 5.4399 APE10-dist-out 9.7364 APE9-dist-in 3.5118 T838E None None XRAY 2.11 0.208 0.247 A 334.0 253.0 16 28 22 6 [[678, 938]] 1.0 4bf2 Homo sapiens STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5.0 257.0 253.0 821 822 823 825 827 709 725 729 800 802 801 803.0 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 4BF2B Q99683 671 940 1374.0 STU:1941 Type1 Inactive DFGin 6.9205 13.8035 BLAminus -128.63, -177.63 56.0, 77.77 -86.85, 11.45 292.4, 104.75 -69.02, -19.49 in-none in 9.7404 Saltbr-none 999.0 HRD-in -67.52, -45.29 72.76, -9.25 none-in-out SNCnio in-out ActLoopNT-in 3.0123 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 145.57 APE9-dihe-na -77.44, -148.98 APE8-dihe-in -83.86, 130.43 APE8-rot-in 307.99 APE67-dihe-in -59.87, -30.7 -43.72, -58.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.6962 APE9-dist-in 3.5274 T838E None None XRAY 2.11 0.208 0.247 B 334.0 252.0 18 28 19 9 [[678, 938]] 1.0 4bf2 Homo sapiens STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5.0 257.0 253.0 821 822 823 825 827 709 725 729 800 802 801 803.0 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 2CLQA Q99683 670 940 1374.0 STU:1941 Type1 Inactive DFGinter 5.9176 8.4686 BABtrans -91.39, 129.8 -141.56, 7.65 -79.81, 110.16 226.87, 94.37 134.88, -46.11 out-out out 10.1274 Saltbr-out 4.7959 HRD-in -81.27, -49.85 78.55, 0.8 out-in-out SNCoio in-out ActLoopNT-in 3.0253 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -136.64, 134.41 APE9-dihe-na -79.2, -159.26 APE8-dihe-in -79.76, 137.19 APE8-rot-in 323.06 APE67-dihe-in -73.67, -16.9 -62.96, -40.27 APE12-dist-in 11.6102 APE11-dist-out 6.2233 APE10-dist-out 10.0395 APE9-dist-in 3.702 None None None XRAY 2.3 0.204 0.257 A 295.0 263.0 8 28 23 5 [[678, 938]] 1.0 2clq Homo sapiens STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5.0 257.0 253.0 821 822 823 825 827 709 725 729 800 802 801 803.0 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 2CLQB Q99683 670 940 1374.0 STU:1941 Type1 Inactive DFGinter 6.5637 8.0205 BABtrans -97.55, 126.7 -140.68, 10.18 -79.54, 109.54 215.05, 109.45 130.73, -46.4 in-none in 9.9798 Saltbr-none 999.0 HRD-in -83.48, -49.36 79.39, -1.77 none-in-out SNCnio in-out ActLoopNT-in 3.0007 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -136.24, 136.94 APE9-dihe-na -82.54, -165.1 APE8-dihe-in -71.26, 138.19 APE8-rot-in 313.5 APE67-dihe-in -70.89, -23.23 -61.89, -43.74 APE12-dist-none 999.0 APE11-dist-out 6.2673 APE10-dist-out 10.0131 APE9-dist-in 3.7494 None None None XRAY 2.3 0.204 0.257 B 295.0 259.0 12 28 20 8 [[678, 938]] 1.0 2clq Homo sapiens STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5.0 257.0 253.0 821 822 823 825 827 709 725 729 800 802 801 803.0 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE PAK4 PAK4_HUMAN 5VEDA O96013 300 589 591.0 STU:601 Type1 Inactive DFGin 7.5909 14.8713 BLAminus -137.67, -169.84 57.61, 74.14 -100.29, 38.24 286.21, 78.54 -72.3, -31.74 in-out in 8.7707 Saltbr-out 5.2787 HRD-in -70.67, -47.26 60.82, 22.3 out-in-in SNCoii in-in ActLoopNT-in 2.9784 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.74, 169.93 APE9-dihe-na 110.0, -167.24 APE8-dihe-in -107.4, 122.99 APE8-rot-in 313.49 APE67-dihe-in -72.02, -18.93 -37.81, -47.81 APE12-dist-in 8.4933 APE11-dist-in 11.1297 APE10-dist-in 5.2711 APE9-dist-in 3.4124 None SEP474 SEP474 XRAY 2.301 0.231 0.277 A 319.0 290.0 0 28 28 0 [[321, 572]] 1.0 5ved Homo sapiens STE_PAK4_HUMAN STE 2.4e-88 301.8 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE STK24 STK24_HUMAN 3CKXA Q9Y6E0 32 310 443.0 STU:60305 Type1 Inactive DFGin 6.5536 14.1491 BLAminus -132.73, 176.63 58.71, 84.09 -98.54, 27.24 290.72, 79.22 -58.51, -31.96 in-out in 8.0183 Saltbr-out 4.1372 HRD-in -69.03, -39.23 63.51, 16.34 out-in-in SNCoii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.66, 153.77 APE9-dihe-na 128.68, -169.17 APE8-dihe-in -106.02, 124.24 APE8-rot-in 327.58 APE67-dihe-in -59.9, -29.27 -40.36, -54.25 APE12-dist-in 8.4325 APE11-dist-in 11.0654 APE10-dist-in 5.4726 APE9-dist-in 3.366 None TPO190 TPO190 XRAY 2.7 0.204 0.268 A 304.0 277.0 2 28 28 0 [[36, 286]] 1.0 3ckx Homo sapiens STE_STK24_HUMAN STE 3.6e-100 340.5 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QMYA Q9Y6E0 20 310 443.0 STU:60401 Type1 Active DFGin 6.7458 14.586 BLAminus -133.42, 171.19 64.86, 84.46 -97.43, 25.83 286.76, 75.76 -58.45, -26.25 in-in in 8.7396 Saltbr-in 3.0921 HRD-in -71.07, -50.71 71.45, 2.06 in-in-in SNCiii in-in ActLoopNT-in 2.8283 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.42, 163.67 APE9-dihe-na 122.07, -169.11 APE8-dihe-in -113.85, 118.11 APE8-rot-in 305.93 APE67-dihe-in -57.67, -29.25 -41.23, -48.77 APE12-dist-in 8.3194 APE11-dist-in 10.9316 APE10-dist-in 5.108 APE9-dist-in 3.2458 None TPO190 TPO190 XRAY 1.883 0.18 0.22 A 310.0 288.0 0 28 28 0 [[36, 286]] 1.0 4qmy Homo sapiens STE_STK24_HUMAN STE 3.9e-100 340.4 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
TKL IRAK4 IRAK4_HUMAN 2OICA Q9NWZ3 163 458 460.0 STU:1 Type1 Active DFGin 7.5415 14.5501 BLAminus -120.17, -157.79 43.1, 78.64 -95.77, 16.12 291.84, 81.73 -52.42, -46.68 in-in in 9.1643 Saltbr-in 2.7447 HRD-in -70.7, -51.8 81.1, -5.15 in-in-in SNCiii in-in ActLoopNT-in 2.8301 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.11, 162.72 APE9-dihe-na 127.09, -176.82 APE8-dihe-in -109.75, 123.25 APE8-rot-in 303.17 APE67-dihe-in -63.31, -16.61 -48.06, -48.45 APE12-dist-in 10.1333 APE11-dist-in 11.7238 APE10-dist-in 6.3469 APE9-dist-in 3.4459 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 A 301.0 279.0 17 30 24 6 [[183, 456]] 1.0 2oic Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICB Q9NWZ3 164 459 460.0 STU:2 Type1 Active DFGin 7.3007 14.318 BLAminus -135.72, -165.01 43.24, 86.39 -100.56, 27.64 301.91, 89.45 -68.65, -40.8 in-in in 8.997 Saltbr-in 3.0216 HRD-in -70.79, -51.12 80.52, -12.66 in-in-in SNCiii in-in ActLoopNT-in 2.8485 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.84, 167.54 APE9-dihe-na 125.4, -168.64 APE8-dihe-in -121.45, 120.26 APE8-rot-in 302.84 APE67-dihe-in -66.81, -13.26 -49.44, -48.37 APE12-dist-in 10.0934 APE11-dist-in 11.7177 APE10-dist-in 6.031 APE9-dist-in 3.6867 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 B 301.0 278.0 18 30 24 6 [[183, 456]] 1.0 2oic Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICC Q9NWZ3 161 458 460.0 STU:3 Type1 None DFGin 7.6419 14.5124 BLAminus -134.38, -175.33 55.45, 88.83 -103.9, 2.57 299.42, 100.27 -42.77, 999.0 in-in in 9.1756 Saltbr-in 3.2966 HRD-in -70.98, -49.49 84.28, -16.44 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -109.35, 145.04 APE9-dihe-na 142.04, -179.34 APE8-dihe-in -123.52, 118.39 APE8-rot-in 307.07 APE67-dihe-in -69.67, -21.31 -65.38, -24.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.5672 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 C 301.0 280.0 18 30 20 10 [[183, 456]] 1.0 2oic Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICD Q9NWZ3 161 459 460.0 STU:4 Type1 Active DFGin 6.9643 14.7946 BLAminus -128.12, -176.74 47.11, 78.66 -89.74, 11.31 298.87, 93.52 -54.67, -36.62 in-in in 8.7014 Saltbr-in 2.6141 HRD-in -65.25, -53.17 80.56, 0.44 in-in-in SNCiii in-in ActLoopNT-in 2.8622 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.06, 151.9 APE9-dihe-na 143.33, 177.59 APE8-dihe-in -104.02, 127.84 APE8-rot-in 302.2 APE67-dihe-in -61.5, -18.42 -54.54, -50.36 APE12-dist-in 10.5716 APE11-dist-in 11.6739 APE10-dist-in 6.1102 APE9-dist-in 3.4836 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 D 301.0 287.0 12 30 28 2 [[183, 456]] 1.0 2oic Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRYC Q9NWZ3 164 458 460.0 STU:503 Type1 Active DFGin 7.3959 13.9911 BLAminus -129.87, 177.33 66.53, 79.75 -106.36, 3.08 302.75, 99.86 -41.96, -44.4 in-in in 9.0503 Saltbr-in 2.876 HRD-in -69.99, -46.9 74.7, -3.92 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.06, 166.37 APE9-dihe-na 122.8, -162.09 APE8-dihe-in -122.72, 120.05 APE8-rot-in 297.38 APE67-dihe-in -61.23, -20.14 -50.62, -47.6 APE12-dist-in 11.8451 APE11-dist-in 12.224 APE10-dist-in 6.9995 APE9-dist-in 3.8635 None TPO345 TPO345 XRAY 2.15 0.212 0.261 C 307.0 281.0 14 30 26 4 [[183, 456]] 1.0 2nry Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRYD Q9NWZ3 164 460 460.0 STU:501 Type1 Active DFGin 7.1034 14.6012 BLAminus -126.69, 167.35 70.82, 64.69 -93.05, 43.05 345.42, 126.85 -89.85, -18.2 in-in in 9.1762 Saltbr-in 2.9498 HRD-in -59.6, -55.9 83.92, -5.49 in-in-in SNCiii in-in ActLoopNT-in 2.7235 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.15, 176.95 APE9-dihe-na 112.24, -167.34 APE8-dihe-in -128.61, 119.15 APE8-rot-in 302.8 APE67-dihe-in -66.3, -17.75 -48.9, -47.71 APE12-dist-in 10.0254 APE11-dist-in 11.6148 APE10-dist-in 6.2715 APE9-dist-in 3.5382 None TPO345 TPO345 XRAY 2.15 0.212 0.261 D 307.0 283.0 14 30 25 5 [[183, 456]] 1.0 2nry Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U97A Q9NWZ3 166 458 460.0 STU:501 Type1 None DFGin 7.218 14.4948 BLAminus -133.4, -177.52 44.45, 65.76 -75.86, 30.58 295.34, 78.33 -61.24, -17.68 in-in in 9.1113 Saltbr-in 2.7963 HRD-in -81.28, -51.43 74.22, 0.69 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.32, 150.98 APE9-dihe-na 154.49, -177.45 APE8-dihe-in -96.07, 115.4 APE8-rot-in 303.66 APE67-dihe-in -67.54, -17.85 -61.65, -28.02 APE12-dist-in 9.909 APE11-dist-in 11.8395 APE10-dist-in 7.0324 APE9-dist-in 3.8244 D311N None None XRAY 2.65 0.206 0.251 A 312.0 272.0 21 30 22 8 [[183, 456]] 1.0 4u97 Homo sapiens TKL_IRAK4_HUMAN TKL 3e-83 285.4 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U9AA Q9NWZ3 166 458 460.0 STU:501 Type1 None DFGin 7.0448 14.9069 BLAminus -101.08, -157.39 29.3, 88.18 -95.05, 25.51 282.71, 82.79 -64.14, 4.87 in-in in 8.9978 Saltbr-in 3.2256 HRD-in -68.43, -44.05 62.5, 13.64 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.36, 146.03 APE9-dihe-na 162.68, -156.1 APE8-dihe-in -121.4, 112.37 APE8-rot-in 316.45 APE67-dihe-in -59.48, -18.83 -58.3, -38.15 APE12-dist-in 9.9834 APE11-dist-in 11.9507 APE10-dist-in 7.2186 APE9-dist-in 3.878 D311N None None XRAY 2.8 0.185 0.24 A 312.0 272.0 21 30 22 8 [[183, 456]] 1.0 4u9a Homo sapiens TKL_IRAK4_HUMAN TKL 3e-83 285.4 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRYA Q9NWZ3 164 458 460.0 STU:504 Type1 Inactive DFGin 7.0388 13.8495 BLBminus -119.68, 177.11 59.06, 71.69 -112.23, -126.05 350.98, 70.79 78.1, -70.69 in-in in 9.0302 Saltbr-in 2.7579 HRD-in -65.27, -50.09 77.33, -7.45 in-in-in SNCiii in-in ActLoopNT-in 2.7537 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.61, 161.22 APE9-dihe-na 128.42, -175.43 APE8-dihe-in -120.1, 117.97 APE8-rot-in 299.02 APE67-dihe-in -57.48, -21.15 -43.86, -55.05 APE12-dist-in 10.9882 APE11-dist-in 13.0534 APE10-dist-in 7.6703 APE9-dist-in 3.6824 None TPO345 TPO345 XRAY 2.15 0.212 0.261 A 307.0 287.0 8 30 25 5 [[183, 456]] 1.0 2nry Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRYB Q9NWZ3 164 458 460.0 STU:502 Type1 Inactive DFGin 7.3303 14.2109 BLBminus -121.91, 179.32 63.59, 83.43 -104.91, -160.11 313.36, 100.13 93.41, -69.05 in-out in 8.9923 Saltbr-out 3.7751 HRD-in -74.38, -53.26 85.42, -10.52 out-in-in SNCoii in-in ActLoopNT-in 2.61 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.77, 162.03 APE9-dihe-na 124.37, -168.49 APE8-dihe-in -121.78, 111.1 APE8-rot-in 307.1 APE67-dihe-in -48.86, -28.56 -36.36, -56.5 APE12-dist-in 9.9324 APE11-dist-in 12.1379 APE10-dist-in 6.4849 APE9-dist-in 3.62 None TPO345 TPO345 XRAY 2.15 0.212 0.261 B 307.0 287.0 8 30 25 5 [[183, 456]] 1.0 2nry Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U97B Q9NWZ3 166 458 460.0 STU:501 Type1 Inactive DFGin 5.2944 14.2173 None -136.34, -175.59 46.99, 62.58 -120.73, 999.0 61.34, 86.78 999.0, 999.0 in-in in 9.393 Saltbr-in 2.9962 HRD-in -71.9, -50.3 83.45, -13.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -128.91, -19.36 APE9-dihe-na -55.91, 145.79 APE8-dihe-in -64.15, 91.3 APE8-rot-in 291.9 APE67-dihe-in -57.49, -34.64 -51.29, -30.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.1454 D311N None None XRAY 2.65 0.206 0.251 B 312.0 270.0 23 30 18 12 [[183, 456]] 1.0 4u97 Homo sapiens TKL_IRAK4_HUMAN TKL 3e-83 285.4 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U9AB Q9NWZ3 166 458 460.0 STU:501 Type1 Inactive DFGin 5.6327 14.406 None -136.0, 173.79 77.97, 80.6 -165.88, 999.0 67.94, 103.04 999.0, 999.0 in-in in 9.4018 Saltbr-in 2.9242 HRD-in -69.54, -47.75 75.57, 5.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -138.84, -18.64 APE9-dihe-na -63.49, 153.65 APE8-dihe-in -64.27, 92.38 APE8-rot-in 304.32 APE67-dihe-in -63.41, -26.11 -54.68, -17.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.3588 D311N None None XRAY 2.8 0.185 0.24 B 312.0 270.0 23 30 18 12 [[183, 456]] 1.0 4u9a Homo sapiens TKL_IRAK4_HUMAN TKL 3e-83 285.4 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL LIMK1 LIMK1_HUMAN 3S95A P53667 330 637 647.0 STU:60001 Type1 Active DFGin 6.5043 14.0715 BLAminus -132.12, 176.01 61.94, 79.29 -96.74, 17.56 299.36, 104.43 -67.12, -24.68 in-in in 7.4783 Saltbr-in 2.7701 HRD-in -69.3, -54.34 71.96, -1.22 in-in-in SNCiii in-in ActLoopNT-in 2.8744 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -137.33, 152.92 APE9-dihe-na 118.99, 175.51 APE8-dihe-in -76.56, 127.6 APE8-rot-na 188.61 APE67-dihe-in -66.82, -23.07 -64.42, -23.72 APE12-dist-in 9.2185 APE11-dist-in 11.4435 APE10-dist-in 5.6449 APE9-dist-in 3.7458 None None None XRAY 1.65 0.157 0.181 A 310.0 288.0 20 42 22 20 [[339, 606]] 1.0 3s95 Homo sapiens TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 3S95B P53667 330 637 647.0 STU:60001 Type1 Active DFGin 6.4648 13.7229 BLAminus -137.18, 172.16 66.04, 80.35 -97.8, 13.37 302.38, 103.91 -61.7, -26.69 in-in in 7.8062 Saltbr-in 2.5961 HRD-in -67.95, -51.91 71.9, -3.03 in-in-in SNCiii in-in ActLoopNT-in 2.8557 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -131.01, 146.52 APE9-dihe-na 126.16, 169.25 APE8-dihe-in -67.25, 124.73 APE8-rot-na 183.11 APE67-dihe-in -72.71, -16.93 -64.76, -21.17 APE12-dist-in 9.1152 APE11-dist-in 11.2682 APE10-dist-in 5.4051 APE9-dist-in 3.7833 None None None XRAY 1.65 0.157 0.181 B 310.0 288.0 20 42 22 20 [[339, 606]] 1.0 3s95 Homo sapiens TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL RIPK2 RIPK2_HUMAN 5NG2A O43353 5 298 540.0 STU:401 Type1 Inactive DFGin 5.9592 13.8755 BLAminus -127.83, 178.19 61.49, 80.49 -96.67, 24.09 288.33, 78.8 -62.82, -31.8 in-in in 8.0911 Saltbr-in 2.9024 HRD-in -73.87, -50.37 57.71, 19.44 in-in-out SNCiio in-out ActLoopNT-in 2.8273 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 149.89 APE8-dihe-in -77.86, 146.25 APE8-rot-out 189.94 APE67-dihe-in -66.59, -20.81 -105.1, 1.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8555 D146N None None XRAY 2.8 0.209 0.226 A 304.0 274.0 20 33 19 14 [[18, 292]] 1.0 5ng2 Homo sapiens TKL_RIPK2_HUMAN TKL 2.6e-72 249.5 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5NG2B O43353 5 298 540.0 STU:401 Type1 Inactive DFGin 5.987 13.9001 BLAminus -127.96, 178.42 61.45, 80.21 -96.5, 23.45 288.92, 78.23 -62.02, -31.71 in-in in 8.0927 Saltbr-in 2.8937 HRD-in -73.84, -50.5 58.4, 18.77 in-in-out SNCiio in-out ActLoopNT-in 2.8272 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.58 APE8-dihe-in -77.44, 145.88 APE8-rot-out 189.53 APE67-dihe-in -67.7, -20.58 -104.84, 1.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.7903 D146N None None XRAY 2.8 0.209 0.226 B 304.0 278.0 16 33 18 15 [[18, 292]] 1.0 5ng2 Homo sapiens TKL_RIPK2_HUMAN TKL 2.6e-72 249.5 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL TGFBR1 TGFR1_HUMAN 5E8XA P36897 200 503 503.0 STU:601 Type1 Active DFGin 7.4008 13.7714 BLAminus -132.02, 177.79 68.95, 84.86 -101.89, 20.89 298.69, 99.78 -60.9, -22.78 in-in in 7.6457 Saltbr-in 3.3162 HRD-in -78.83, -50.32 78.23, -2.28 in-in-in SNCiii in-in ActLoopNT-in 2.9268 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.2, 171.93 APE9-dihe-na 104.3, 177.57 APE8-dihe-in -80.96, 119.4 APE8-rot-in 304.53 APE67-dihe-in -55.33, -34.35 -53.44, -41.29 APE12-dist-in 11.7091 APE11-dist-in 11.9272 APE10-dist-in 6.2584 APE9-dist-in 3.9463 T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F None None XRAY 1.45 0.191 0.21 A 307.0 304.0 0 32 32 0 [[205, 494]] 1.0 5e8x Homo sapiens TKL_TGFBR1_HUMAN TKL 2.3e-85 292.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 5E8WA P36897 200 501 503.0 STU:60601 Type1 Active DFGin 6.2162 12.9909 BLAminus -115.91, -168.56 48.03, 66.8 -87.81, 6.99 303.66, 6.47 -53.89, -34.67 in-in in 7.5613 Saltbr-in 2.815 HRD-in -71.33, -51.46 73.08, -1.55 in-in-in SNCiii in-in ActLoopNT-in 2.9924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -81.36, -32.83 APE9-dihe-na -81.66, -157.24 APE8-dihe-in -82.54, 122.58 APE8-rot-in 299.35 APE67-dihe-in -53.78, -37.25 -53.32, -45.52 APE12-dist-in 13.0541 APE11-dist-in 12.4184 APE10-dist-in 6.2997 APE9-dist-in 3.7378 T204D None None XRAY 1.86 0.168 0.186 A 307.0 302.0 0 32 32 0 [[205, 494]] 1.0 5e8w Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR2 TGFR2_HUMAN 5E8YA P37173 240 541 567.0 STU:601 Type1 Inactive DFGin 7.4313 13.6382 ABAminus -147.57, -29.88 -97.01, 88.29 -98.27, 19.66 300.85, 114.87 -63.28, -27.98 in-in in 7.6628 Saltbr-in 2.6836 HRD-in -60.19, -53.17 75.99, -7.12 in-in-in SNCiii in-in ActLoopNT-in 2.8159 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.67, 141.68 APE9-dihe-na 119.62, -164.78 APE8-dihe-in -99.54, 120.03 APE8-rot-in 310.13 APE67-dihe-in -59.04, -35.21 -51.44, -37.92 APE12-dist-in 11.2111 APE11-dist-in 12.0735 APE10-dist-in 5.9745 APE9-dist-in 4.0108 E431A,R433A,E485A,K488A,R493A,R495A None None XRAY 2.05 0.198 0.227 A 316.0 298.0 4 32 32 0 [[244, 540]] 1.0 5e8y Homo sapiens TKL_TGFBR2_HUMAN TKL 1.9e-77 266.3 2.0 266.0 265.0 396 397 398 400 402 277 290 294 376 378 377 379.0 446 428 423 422 421 420 419 418 417 326 TGF-beta receptor type-2
TYR ALK ALK_HUMAN 3LCSA Q9UM73 1096 1399 1620.0 STU:1 Type1 Inactive DFGin 6.3299 14.9123 ABAminus -115.64, -37.74 -102.74, 114.2 -112.42, 20.01 289.12, 86.66 -56.01, -38.26 in-in in 7.78 Saltbr-in 2.6618 HRD-in -69.52, -44.32 78.89, -12.54 in-out-out SNCioo out-out ActLoopNT-out 6.7937 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.07, -13.05 APE9-dihe-in -64.04, 139.47 APE8-dihe-in -80.51, 60.39 APE8-rot-na 31.54 APE67-dihe-in -67.01, -14.6 -60.37, -27.86 APE12-dist-na 15.3078 APE11-dist-na 15.5689 APE10-dist-na 10.5385 APE9-dist-out 8.2956 S1281G None None XRAY 1.95 0.196 0.229 A 344.0 304.0 0 30 30 0 [[1116, 1385]] 1.0 3lcs Homo sapiens TYR_ALK_HUMAN TYR 5e-90 307.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR CSK CSK_HUMAN 3D7TA P41240 188 450 450.0 STU:6335 Type1 Inactive DFGin 4.8478 13.7273 None -129.86, -75.48 -112.49, 120.17 -68.38, 132.53 310.55, 71.3 -108.94, 999.0 in-in in 9.7085 Saltbr-in 3.505 HRD-in -84.81, -41.33 76.65, -6.36 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 92.32 APE8-rot-na 27.67 APE67-dihe-in -57.33, -30.65 -43.31, -55.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K361A,K362A None None XRAY 2.899 0.239 0.278 A 269.0 249.0 14 25 11 14 [[195, 442]] 1.0 3d7t Homo sapiens TYR_CSK_HUMAN TYR 5.7e-87 297.2 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
TYR CSK CSK_HUMAN 1BYGA P41240 187 448 450.0 STU:501 Type1 Inactive DFGinter 10.8596 7.9227 BABtrans -99.17, 153.06 -105.84, -7.01 -68.56, 146.18 156.4, 90.07 -161.79, 133.09 out-out out 14.7753 Saltbr-out 12.6461 HRD-in -79.54, -44.6 72.05, -5.51 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.52 APE8-dihe-in -71.25, 96.92 APE8-rot-na 16.81 APE67-dihe-in -75.84, -8.12 -42.46, -43.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2924 None None None XRAY 2.4 0.199 0.287 A 278.0 246.0 16 25 13 12 [[195, 442]] 1.0 1byg Homo sapiens TYR_CSK_HUMAN TYR 1.2e-87 299.5 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
TYR EPHB4 EPHB4_HUMAN 3ZEWA P54760 609 888 987.0 STU:1889 Type1 None DFGin 6.1222 14.3588 BLAminus -139.16, 174.72 57.83, 79.91 -97.95, 22.7 299.52, 94.02 -63.4, -45.19 in-in in 8.066 Saltbr-in 2.7962 HRD-in -71.2, -51.67 69.26, -8.65 in-in-none SNCiin in-none ActLoopNT-in 2.8209 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 56.2 APE9-dihe-in -113.28, 124.67 APE8-dihe-in -75.39, 88.73 APE8-rot-na 23.8 APE67-dihe-in -74.18, -2.68 -39.84, -58.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.2917 APE9-dist-in 6.0712 None PTR774 PTR774 XRAY 2.5 0.24 0.282 A 298.0 270.0 10 33 27 6 [[615, 876]] 1.0 3zew Homo sapiens TYR_EPHB4_HUMAN TYR 2.6e-104 354.1 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 3ZEWB P54760 609 887 987.0 STU:1888 Type1 None DFGin 6.5999 14.6897 BLAminus -136.46, 179.33 65.25, 57.03 -88.32, 123.85 306.76, 101.31 132.26, 999.0 in-none in 7.638 Saltbr-none 999.0 HRD-in -68.01, -45.09 76.33, -22.89 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.88 APE8-dihe-in -93.06, 95.29 APE8-rot-na 27.85 APE67-dihe-in -68.25, -2.97 -47.06, -56.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5541 None PTR774 PTR774 XRAY 2.5 0.24 0.282 B 298.0 252.0 27 33 12 21 [[615, 876]] 1.0 3zew Homo sapiens TYR_EPHB4_HUMAN TYR 2.6e-104 354.1 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2YN8A P54760 608 888 987.0 STU:1889 Type1 Inactive DFGin 6.4266 14.6174 None -130.9, 178.33 70.32, 85.06 -121.95, 999.0 309.1, 102.44 999.0, 999.0 in-in in 7.5327 Saltbr-in 2.7506 HRD-in -74.77, -43.96 71.71, -21.91 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.38 APE8-rot-na 24.51 APE67-dihe-in -59.12, -26.62 -41.36, -49.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y774E,A803V,V870I None None XRAY 2.11 0.197 0.234 A 298.0 253.0 28 33 10 23 [[615, 876]] 1.0 2yn8 Homo sapiens TYR_EPHB4_HUMAN TYR 4.3e-105 356.6 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2YN8B P54760 606 888 987.0 STU:1889 Type1 Inactive DFGin 6.4286 14.6268 None -131.1, 178.0 70.17, 85.21 -120.37, 999.0 309.66, 103.01 999.0, 999.0 in-in in 7.4864 Saltbr-in 2.7603 HRD-in -75.37, -48.88 76.16, -20.77 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.61 APE8-rot-na 24.46 APE67-dihe-in -59.58, -26.36 -40.69, -50.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y774E,A803V,V870I None None XRAY 2.11 0.197 0.234 B 298.0 260.0 23 33 10 23 [[615, 876]] 1.0 2yn8 Homo sapiens TYR_EPHB4_HUMAN TYR 4.3e-105 356.6 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR FES FES_HUMAN 3BKBA P07332 449 821 822.0 STU:826 Type1 Inactive DFGin 6.8661 14.4239 BLAminus -130.98, -162.57 38.75, 71.71 -85.89, 14.89 281.41, 76.5 -59.73, -36.44 in-in in 6.7723 Saltbr-in 2.6204 HRD-in -78.26, -50.49 76.66, -9.4 in-in-out SNCiio in-out ActLoopNT-in 2.8204 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 47.37, 40.72 APE9-dihe-in -62.75, 132.26 APE8-dihe-in -76.49, 72.71 APE8-rot-na 30.4 APE67-dihe-in -70.68, -13.35 -50.64, -47.62 APE12-dist-na 8.3405 APE11-dist-na 11.9812 APE10-dist-na 11.2254 APE9-dist-in 7.3541 None None None XRAY 1.78 0.15 0.189 A 377.0 373.0 0 30 30 0 [[561, 816]] 1.0 3bkb Homo sapiens TYR_FES_HUMAN TYR 6.6e-94 320.0 1.0 260.0 260.0 700 701 702 704 706 590 607 611 680 682 681 683.0 742 730 725 724 723 722 721 720 719 637 Tyrosine-protein kinase Fes/Fps
TYR FES FES_HUMAN 3CBLA P07332 448 821 822.0 STU:60901,STU:60902,STU:60903 Type1,Allosteric,Allosteric Active DFGin 6.9919 14.3472 BLAminus -129.39, -161.99 36.63, 77.42 -90.17, 19.41 283.19, 78.42 -59.92, -34.07 in-in in 7.0184 Saltbr-in 2.618 HRD-in -73.99, -51.91 78.82, -2.64 in-in-in SNCiii in-in ActLoopNT-in 2.7424 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.35, 116.24 APE9-dihe-in -118.34, 122.46 APE8-dihe-in -80.03, 88.22 APE8-rot-na 26.81 APE67-dihe-in -66.64, -12.19 -59.28, -46.73 APE12-dist-na 13.8621 APE11-dist-na 9.6806 APE10-dist-na 8.625 APE9-dist-in 6.8668 None None None XRAY 1.75 0.183 0.227 A 377.0 354.0 0 30 30 0 [[561, 816]] 1.0 3cbl Homo sapiens TYR_FES_HUMAN TYR 6.6e-94 320.0 1.0 260.0 260.0 700 701 702 704 706 590 607 611 680 682 681 683.0 742 730 725 724 723 722 721 720 719 637 Tyrosine-protein kinase Fes/Fps
TYR FES FES_HUMAN 3CD3A P07332 448 821 822.0 STU:60901,STU:60902,STU:60903 Type1,Allosteric,Allosteric Active DFGin 7.0423 14.319 BLAminus -131.29, -161.96 36.95, 76.94 -87.41, 20.64 283.25, 80.52 -64.77, -30.01 in-in in 6.9546 Saltbr-in 2.4508 HRD-in -75.66, -48.21 74.09, -7.23 in-in-in SNCiii in-in ActLoopNT-in 2.8131 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.76, 114.63 APE9-dihe-in -118.9, 123.98 APE8-dihe-in -79.16, 82.58 APE8-rot-na 23.88 APE67-dihe-in -66.61, -9.96 -49.19, -54.65 APE12-dist-na 14.1032 APE11-dist-na 10.0433 APE10-dist-na 8.9304 APE9-dist-in 7.039 None PTR713 PTR713 XRAY 1.98 0.188 0.247 A 377.0 351.0 4 30 30 0 [[561, 816]] 1.0 3cd3 Homo sapiens TYR_FES_HUMAN TYR 6.6e-94 320.0 1.0 260.0 260.0 700 701 702 704 706 590 607 611 680 682 681 683.0 742 730 725 724 723 722 721 720 719 637 Tyrosine-protein kinase Fes/Fps
TYR FYN FYN_HUMAN 2DQ7X P06241 261 523 537.0 STU:60902 Type1 Active DFGin 6.9701 13.8533 BLAminus -137.79, 173.21 69.46, 82.83 -98.97, 30.24 286.34, 86.38 -56.5, -37.75 in-in in 7.7541 Saltbr-in 2.468 HRD-in -90.12, -49.46 72.41, 2.38 in-in-in SNCiii in-in ActLoopNT-in 2.8825 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.8, 126.18 APE9-dihe-in -111.81, 159.77 APE8-dihe-in -55.65, 79.81 APE8-rot-na 29.61 APE67-dihe-in -72.56, -28.8 -30.08, -40.64 APE12-dist-na 13.298 APE11-dist-na 8.6792 APE10-dist-na 12.4565 APE9-dist-in 6.2157 None PTR420 PTR420 XRAY 2.8 0.255 0.281 X 283.0 263.0 0 29 29 0 [[271, 522]] 1.0 2dq7 Homo sapiens TYR_FYN_HUMAN TYR 2.6e-94 321.3 1.0 260.0 260.0 407 408 409 411 413 299 314 318 387 389 388 390.0 448 436 431 430 429 428 427 426 425 343 Tyrosine-protein kinase Fyn
TYR ITK ITK_HUMAN 1SM2A Q08881 357 619 620.0 STU:301 Type1 Inactive DFGin 5.4974 13.3207 BLBplus -148.18, -157.96 48.2, 18.11 -92.5, -172.62 59.26, 91.5 71.27, 999.0 out-out out 10.5039 Saltbr-out 8.0102 HRD-out -81.72, 93.89 -66.35, 12.1 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.52 APE8-rot-na 340.44 APE67-dihe-in -77.92, -11.34 -60.73, -6.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.246 0.292 A 264.0 245.0 18 29 11 18 [[363, 614]] 1.0 1sm2 Homo sapiens TYR_ITK_HUMAN TYR 9.2e-93 316.2 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SNUA Q08881 357 619 620.0 STU:301 Type1 Inactive DFGin 5.4095 13.5857 BLBplus -121.03, -147.07 39.99, 19.77 -95.61, 161.03 65.42, 97.15 81.16, 999.0 out-out out 10.9852 Saltbr-out 7.7298 HRD-out -99.78, 92.32 -72.7, 37.05 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.98 APE8-rot-na 339.02 APE67-dihe-in -71.29, -26.27 -59.31, -15.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.262 0.295 A 264.0 245.0 18 29 11 18 [[363, 614]] 1.0 1snu Homo sapiens TYR_ITK_HUMAN TYR 9.2e-93 316.2 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SM2B Q08881 358 617 620.0 STU:621 Type1 Inactive DFGin 5.378 13.3785 None -126.46, -161.15 38.96, 42.72 -115.58, 999.0 63.86, 78.79 999.0, 999.0 out-out out 11.099 Saltbr-out 6.8051 HRD-out -89.1, 89.71 -64.14, 17.77 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 70.78 APE8-rot-na 24.5 APE67-dihe-in -53.23, -18.63 -53.68, -42.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.246 0.292 B 264.0 241.0 19 29 10 19 [[363, 614]] 1.0 1sm2 Homo sapiens TYR_ITK_HUMAN TYR 9.2e-93 316.2 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SNUB Q08881 358 617 620.0 STU:621 Type1 Inactive DFGin 5.3215 13.3612 None -135.24, -161.39 47.41, 33.44 -112.08, 999.0 66.07, 77.87 999.0, 999.0 out-out out 11.1179 Saltbr-out 7.4836 HRD-out -85.26, 96.7 -69.16, 21.34 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 61.67 APE8-rot-na 31.48 APE67-dihe-in -68.53, -31.16 -49.5, -27.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.262 0.295 B 264.0 241.0 19 29 10 19 [[363, 614]] 1.0 1snu Homo sapiens TYR_ITK_HUMAN TYR 9.2e-93 316.2 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR KIT KIT_HUMAN 8S19A P10721 566 931 976.0 STU:61001 Type1 Active DFGin 7.4038 13.6674 BLAminus -127.12, -176.58 57.62, 86.03 -104.33, 27.64 287.94, 75.89 -65.62, -32.19 in-in in 8.5279 Saltbr-in 2.8072 HRD-in -86.95, -44.99 76.04, 4.46 in-in-in SNCiii in-in ActLoopNT-in 2.9798 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.78, 135.36 APE9-dihe-in -116.81, 146.55 APE8-dihe-in -80.8, 82.76 APE8-rot-na 31.59 APE67-dihe-in -71.09, -10.53 -60.41, -40.84 APE12-dist-na 14.6501 APE11-dist-na 10.0069 APE10-dist-na 13.4676 APE9-dist-in 7.8988 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.3 0.186 0.208 A 327.0 287.0 1 30 29 1 [[589, 926]] 1.0 8s19 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1.0 261.0 261.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 8S19B P10721 566 930 976.0 STU:61001 Type1 Active DFGin 7.3271 13.5376 BLAminus -128.07, -176.35 62.24, 79.08 -101.65, 27.17 286.46, 78.41 -65.78, -31.3 in-in in 8.4236 Saltbr-in 3.2444 HRD-in -86.63, -46.82 74.21, 3.84 in-in-in SNCiii in-in ActLoopNT-in 2.9724 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.88, 148.22 APE9-dihe-in -128.01, 146.9 APE8-dihe-in -81.2, 79.5 APE8-rot-na 31.77 APE67-dihe-in -74.43, -9.18 -60.72, -38.08 APE12-dist-na 14.1209 APE11-dist-na 10.1321 APE10-dist-na 13.2289 APE9-dist-in 7.6951 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.3 0.186 0.208 B 327.0 284.0 3 30 30 0 [[589, 926]] 1.0 8s19 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1.0 261.0 261.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR LCK LCK_HUMAN 1QPJA P06239 236 501 509.0 STU:902 Type1 Active DFGin 6.6673 13.9099 BLAminus -132.46, 174.81 60.31, 82.59 -95.23, 22.99 299.73, 90.17 -64.21, -26.94 in-in in 8.1293 Saltbr-in 2.566 HRD-in -98.38, -45.69 71.81, -4.26 in-in-in SNCiii in-in ActLoopNT-in 2.8829 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.6, 145.72 APE9-dihe-in -137.74, 152.71 APE8-dihe-in -60.2, 95.29 APE8-rot-na 326.72 APE67-dihe-in -63.01, -25.44 -48.62, -46.8 APE12-dist-na 14.7028 APE11-dist-na 10.0918 APE10-dist-na 12.9477 APE9-dist-in 7.0162 None PTR394 PTR394 XRAY 2.2 0.214 0.267 A 279.0 266.0 0 29 29 0 [[245, 496]] 1.0 1qpj Homo sapiens TYR_LCK_HUMAN TYR 1.4e-94 322.2 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TYR LCK LCK_HUMAN 1QPDA P06239 231 502 509.0 STU:902 Type1 Active DFGin 6.4653 14.1815 BLAminus -132.18, 176.72 55.71, 84.19 -94.48, 25.19 297.78, 91.73 -59.44, -39.94 in-in in 8.4176 Saltbr-in 2.8434 HRD-in -101.42, -45.84 73.23, 2.58 in-in-in SNCiii in-in ActLoopNT-in 2.9762 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.47, 143.78 APE9-dihe-in -134.7, 155.74 APE8-dihe-in -59.6, 112.24 APE8-rot-na 334.8 APE67-dihe-in -60.08, -21.25 -55.42, -48.02 APE12-dist-na 14.972 APE11-dist-na 10.2937 APE10-dist-na 12.9671 APE9-dist-in 6.9506 None PTR394 PTR394 XRAY 2.0 0.195 0.237 A 279.0 272.0 0 29 29 0 [[245, 496]] 1.0 1qpd Homo sapiens TYR_LCK_HUMAN TYR 3.6e-93 317.5 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TYR LYN LYN_HUMAN 3A4OX P07948 238 505 512.0 STU:60902 Type1 Inactive DFGin 6.6497 15.5814 None -103.69, -177.97 54.14, 148.85 -166.58, 42.86 276.85, 106.11 -75.66, -40.91 in-in in 9.1227 Saltbr-in 3.2202 HRD-in -82.15, -55.06 93.66, -27.17 in-in-out SNCiio in-out ActLoopNT-in 2.8615 ActLoopCT-out TYR APEdihe_ooiai APEdist_aaai APE10-dihe-out -155.78, -36.41 APE9-dihe-out 3.09, -67.88 APE8-dihe-in -48.66, 80.66 APE8-rot-na 28.53 APE67-dihe-in -67.02, 39.44 -53.16, -65.62 APE12-dist-na 7.583 APE11-dist-na 3.3978 APE10-dist-na 8.537 APE9-dist-in 6.4504 None None None XRAY 3.0 0.293 0.324 X 286.0 259.0 9 29 20 9 [[247, 499]] 1.0 3a4o Homo sapiens TYR_LYN_HUMAN TYR 1.2e-95 325.7 1.0 260.0 260.0 384 385 386 388 390 275 290 294 364 366 365 367.0 425 413 408 407 406 405 404 403 402 320 Tyrosine-protein kinase Lyn
TYR NTRK1 NTRK1_HUMAN 9DAIA P04629 501 796 796.0 STU:801 Type1 Inactive DFGin 7.3285 15.1025 None -134.39, -155.28 28.01, 68.03 -73.72, 999.0 288.62, 88.06 999.0, 999.0 in-in in 9.6981 Saltbr-in 3.2532 HRD-in -62.59, -42.57 78.74, -33.91 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.11 APE8-dihe-in -86.91, 69.17 APE8-rot-na 30.89 APE67-dihe-in -62.36, -34.09 -52.62, -31.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4955 None None None XRAY 2.864 0.22 0.277 A 320.0 264.0 32 30 11 19 [[510, 783]] 1.0 9dai Homo sapiens TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR SYK KSYK_HUMAN 1XBCA P43405 363 635 635.0 STU:60001 Type1 Active DFGin 6.6992 14.2365 BLAminus -133.2, -171.25 54.9, 81.04 -97.63, 25.87 287.7, 80.31 -62.67, -30.77 in-in in 8.107 Saltbr-in 2.6812 HRD-in -73.91, -54.08 72.64, 5.62 in-in-in SNCiii in-in ActLoopNT-in 2.8734 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.93, 102.31 APE9-dihe-in -115.14, 122.86 APE8-dihe-in -77.21, 74.28 APE8-rot-na 27.13 APE67-dihe-in -62.04, -14.77 -51.56, -42.64 APE12-dist-na 10.2255 APE11-dist-na 10.6613 APE10-dist-na 9.591 APE9-dist-in 6.8302 None None None XRAY 2.0 0.246 0.294 A 291.0 267.0 6 31 31 0 [[370, 628]] 1.0 1xbc Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR ZAP70 ZAP70_HUMAN 1U59A P43403 328 606 619.0 STU:60100 Type1 Inactive DFGin 6.4492 14.6547 BLAminus -132.39, 179.54 60.68, 79.94 -93.24, 26.52 286.21, 85.42 -61.36, -30.97 in-in in 8.5451 Saltbr-in 2.6048 HRD-in -75.34, -52.46 82.3, -36.8 in-in-out SNCiio in-out ActLoopNT-in 2.9844 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -109.77, 150.26 APE9-dihe-in -93.67, 137.73 APE8-dihe-in -75.36, 68.87 APE8-rot-na 32.83 APE67-dihe-in -59.55, -7.44 -43.09, -46.01 APE12-dist-na 14.4853 APE11-dist-na 13.5249 APE10-dist-na 14.7003 APE9-dist-out 9.0998 None None None XRAY 2.3 0.217 0.271 A 287.0 276.0 3 31 31 0 [[338, 595]] 1.0 1u59 Homo sapiens TYR_ZAP70_HUMAN TYR 2.5e-90 308.2 6.0 259.0 254.0 478 479 480 482 484 369 386 390 458 460 459 461.0 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70
TYR RTKC8 A9VBW0_MONBE 8E4TA A9VBW0 1412 1684 1911.0 STU:61901,STU:61902 Type1,Allosteric Inactive DFGin 5.7982 14.2575 BLAminus -127.66, 178.05 63.29, 82.89 -96.19, 23.12 289.39, 77.3 -56.36, -33.99 in-in in 8.0346 Saltbr-in 2.8966 HRD-in -84.2, -48.48 70.19, 15.14 in-in-out SNCiio in-out ActLoopNT-in 2.9354 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.95, 2.58 APE9-dihe-in -47.64, 117.94 APE8-dihe-in -73.3, 83.54 APE8-rot-na 25.08 APE67-dihe-in -68.63, -15.26 -57.08, -37.63 APE12-dist-na 12.1483 APE11-dist-na 14.5735 APE10-dist-na 11.1729 APE9-dist-out 8.0268 None None None XRAY 1.95 0.206 0.255 A 283.0 268.0 5 29 24 5 [[1423, 1678]] 1.0 8e4t Monosiga brevicollis TYR_RTKC8_MONBE TYR 8.9e-85 290.0 3.0 260.0 258.0 1563 1564 1565 1567 1569 1455 1472 1476 1543 1545 1544 1546.0 1604 1592 1587 1586 1585 1584 1583 1582 1581 1502 non-specific protein-tyrosine kinase
CAMK PRKAA1 AAPK1_MOUSE 5UFUA Q5EG47 20 559 559.0 STU:60601,85V:60602 Type1,Allosteric Inactive DFGin 7.217 14.2462 BLAminus -131.5, 162.6 65.85, 93.86 -99.38, 24.57 280.79, 65.36 -57.61, -46.84 in-in in 9.7642 Saltbr-in 2.7483 HRD-out -69.82, 100.36 -85.07, 166.65 in-in-out SNCiio in-out ActLoopNT-in 2.7449 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -90.3, 155.77 APE9-dihe-na 100.05, 157.58 APE8-dihe-in -52.88, 143.31 APE8-rot-out 164.19 APE67-dihe-in -65.21, -41.11 -61.15, -33.48 APE12-dist-in 7.5744 APE11-dist-in 11.0949 APE10-dist-in 5.1302 APE9-dist-out 6.066 None TPO183 TPO183 XRAY 3.45 0.195 0.238 A 503.0 249.0 0 27 27 0 [[27, 279]] 1.0 5ufu Mus musculus CAMK_PRKAA1_MOUSE CAMK 3.9e-89 304.5 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
TKL RIPK4 RIPK4_MOUSE 5WNLA Q9ERK0 10 288 786.0 STU:401 Type1 Inactive DFGin 5.3569 14.5725 BLAminus -134.03, 174.48 63.33, 81.72 -96.92, 21.29 289.3, 76.96 -59.26, -33.93 in-in in 8.7782 Saltbr-in 2.733 HRD-in -81.33, -54.8 69.56, 11.14 in-in-out SNCiio in-out ActLoopNT-in 3.066 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 144.67 APE9-dihe-na 85.9, -57.36 APE8-dihe-out -63.74, -13.96 APE8-rot-out 59.65 APE67-dihe-in -59.52, -31.71 -58.84, -41.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.6648 APE9-dist-out 11.7093 D143N None None XRAY 2.5 0.224 0.256 A 342.0 262.0 17 31 17 14 [[19, 285]] 1.0 5wnl Mus musculus TKL_RIPK4_MOUSE TKL 1.4e-74 257.0 4.0 266.0 263.0 160 161 162 164 166 51 69 73 140 142 141 143.0 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4
CAMK CDPK2 CDPK2_PLAFK 4MVFA O15865 60 511 513.0 STU:60601 Type1 Inactive DFGin 6.8149 14.4306 ABAminus -113.07, -2.16 -142.08, 130.21 -125.4, 28.29 288.94, 85.92 -61.14, -23.54 in-in in 9.4389 Saltbr-in 2.7799 HRD-in -82.17, -47.76 70.19, 0.74 in-in-none SNCiin in-none ActLoopNT-in 2.8942 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.195 0.23 A 506.0 405.0 39 27 8 19 [[72, 326]] 1.0 4mvf Plasmodium falciparum CAMK_CDPK2_PLAFK CAMK 7.5e-88 300.5 1.0 256.0 256.0 212 213 214 216 218 101 117 121 189 191 190 192.0 250 239 234 233 232 231 230 229 228 147 Calcium-dependent protein kinase 2
CAMK PRKAA1 AAPK1_RAT 6E4TA P54645 20 559 559.0 HTV:60601,STU:60602 Allosteric,Type1 Inactive DFGin 7.4354 14.2606 ABAminus -127.14, -39.21 -103.64, 92.84 -85.31, 24.03 289.4, 72.26 -73.07, -34.04 out-in out 10.0186 Saltbr-in 3.1477 HRD-out -67.59, 99.51 -83.8, 164.42 in-in-out SNCiio in-out ActLoopNT-in 2.8682 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -86.15, 147.86 APE9-dihe-na 86.15, 170.33 APE8-dihe-in -53.88, 128.36 APE8-rot-out 178.71 APE67-dihe-in -78.32, -32.83 -55.05, -15.97 APE12-dist-in 7.7373 APE11-dist-in 10.9496 APE10-dist-in 5.1078 APE9-dist-out 6.0467 None TPO183 TPO183 XRAY 3.4 0.218 0.245 A 503.0 362.0 0 27 27 0 [[27, 279]] 1.0 6e4t Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 4QFGA P54645 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.5311 14.8343 ABAminus -129.83, -31.53 -108.51, 95.59 -86.54, 22.6 280.04, 73.48 -69.33, -40.23 in-in in 8.7666 Saltbr-in 2.7784 HRD-out -72.26, 87.26 -69.37, 157.2 in-in-in SNCiii in-in ActLoopNT-in 2.8109 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.6, 162.5 APE9-dihe-na 108.84, 159.63 APE8-dihe-in -59.24, 132.89 APE8-rot-in 308.45 APE67-dihe-in -56.78, -50.62 -41.69, -48.89 APE12-dist-in 7.8041 APE11-dist-in 11.2797 APE10-dist-in 5.635 APE9-dist-in 5.9765 None TPO183 TPO183 XRAY 3.46 0.224 0.267 A 503.0 366.0 0 27 27 0 [[27, 279]] 1.0 4qfg Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 4QFRA P54645 20 559 559.0 STU:60601,32J:60606 Type1,Allosteric Inactive DFGin 7.1795 14.4615 ABAminus -135.94, -12.01 -110.66, 91.74 -85.33, 22.64 282.92, 78.98 -65.65, -45.25 in-in in 9.739 Saltbr-in 3.3805 HRD-out -83.58, 90.91 -68.37, 165.86 in-in-out SNCiio in-out ActLoopNT-in 2.9366 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -94.98, 155.0 APE9-dihe-na 104.66, 160.03 APE8-dihe-in -55.29, 137.08 APE8-rot-out 167.48 APE67-dihe-in -71.49, -40.84 -60.68, -24.54 APE12-dist-in 7.6236 APE11-dist-in 11.1612 APE10-dist-in 5.1813 APE9-dist-out 6.0551 None TPO183 TPO183 XRAY 3.34 0.212 0.249 A 503.0 362.0 0 27 27 0 [[27, 279]] 1.0 4qfr Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 4QFSA P54645 20 559 559.0 STU:60601,32H:60602 Type1,Allosteric Inactive DFGin 6.8904 14.3775 ABAminus -124.9, -28.24 -112.18, 85.76 -75.27, 7.65 284.68, 79.39 -57.92, -39.76 in-in in 9.7636 Saltbr-in 3.4673 HRD-out -68.1, 87.64 -69.41, 154.35 in-in-out SNCiio in-out ActLoopNT-in 2.903 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -125.95, 151.68 APE9-dihe-na 98.37, 158.77 APE8-dihe-in -43.48, 135.81 APE8-rot-out 168.88 APE67-dihe-in -73.46, -39.34 -64.14, -18.67 APE12-dist-in 7.7211 APE11-dist-in 11.3043 APE10-dist-in 5.5453 APE9-dist-out 6.2808 None TPO183 TPO183 XRAY 3.55 0.228 0.269 A 503.0 362.0 0 27 27 0 [[27, 279]] 1.0 4qfs Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 6E4UA P54645 20 559 559.0 STU:60601,HU7:60602 Type1,Allosteric Inactive DFGin 7.2287 14.4867 ABAminus -129.48, -32.52 -101.47, 99.32 -91.51, 18.06 282.35, 82.84 -62.17, -40.84 in-in in 9.7775 Saltbr-in 2.8999 HRD-out -78.35, 93.03 -70.69, 167.95 in-in-out SNCiio in-out ActLoopNT-in 2.9076 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -104.64, -70.24 APE9-dihe-na -62.49, -169.58 APE8-dihe-in -69.59, 137.05 APE8-rot-out 166.67 APE67-dihe-in -62.15, -31.58 -48.72, -38.44 APE12-dist-in 7.8875 APE11-dist-in 10.9362 APE10-dist-in 5.3018 APE9-dist-out 6.1152 None TPO183 TPO183 XRAY 3.27 0.213 0.231 A 503.0 366.0 0 27 27 0 [[27, 279]] 1.0 6e4u Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 6E4WA P54645 20 559 559.0 STU:60601,HUG:60602 Type1,Allosteric Inactive DFGin 7.496 14.4075 ABAminus -129.16, -43.82 -96.4, 98.46 -86.03, 19.41 285.3, 80.28 -65.13, -32.32 out-in out 10.281 Saltbr-in 3.4137 HRD-out -66.89, 97.04 -81.94, 166.54 in-in-out SNCiio in-out ActLoopNT-in 2.8853 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -119.09, -68.02 APE9-dihe-na -76.27, -164.02 APE8-dihe-in -59.87, 132.49 APE8-rot-out 168.71 APE67-dihe-in -67.7, -51.69 -45.66, -33.67 APE12-dist-in 7.7135 APE11-dist-in 10.8706 APE10-dist-in 5.4855 APE9-dist-out 6.0807 None TPO183 TPO183 XRAY 3.35 0.21 0.244 A 503.0 362.0 0 27 27 0 [[27, 279]] 1.0 6e4w Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 5T5TA P54645 20 559 559.0 STU:60601 Type1 Inactive DFGin 7.2749 14.4462 BLAminus -131.93, 169.19 62.59, 84.7 -94.86, 17.97 279.02, 73.94 -55.16, -41.28 in-in in 9.798 Saltbr-in 3.1713 HRD-out -77.74, 95.53 -76.17, 164.09 in-in-out SNCiio in-out ActLoopNT-in 2.8385 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -99.9, 148.13 APE9-dihe-na 108.52, 171.16 APE8-dihe-in -60.68, 140.01 APE8-rot-out 180.44 APE67-dihe-in -65.41, -31.73 -60.15, -34.97 APE12-dist-in 7.7967 APE11-dist-in 11.284 APE10-dist-in 5.3159 APE9-dist-out 6.2478 None TPO183 TPO183 XRAY 3.46 0.212 0.231 A 503.0 369.0 0 27 27 0 [[27, 279]] 1.0 5t5t Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 4CFHA P54645 21 481 559.0 STU:61550 Type1 Inactive DFGin 6.6088 14.765 None -117.21, -79.88 -80.17, 112.56 -105.2, 27.91 278.75, 78.83 -62.93, -29.8 in-in in 9.2938 Saltbr-in 2.6645 HRD-out -123.7, 94.84 -71.28, 163.89 in-in-out SNCiio in-out ActLoopNT-in 3.0286 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiio APE10-dihe-na -124.99, -9.44 APE9-dihe-na -61.07, -171.7 APE8-dihe-in -76.22, 167.06 APE8-rot-in 301.11 APE67-dihe-out -88.03, -177.87 -58.32, -48.27 APE12-dist-in 8.3547 APE11-dist-in 10.8638 APE10-dist-in 5.2822 APE9-dist-out 6.0779 None TPO183,TPO388 TPO183,TPO388 XRAY 3.24 0.234 0.268 A 493.0 402.0 0 27 27 0 [[27, 279]] 1.0 4cfh Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.7e-89 304.6 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 5KQ5A P54645 21 559 559.0 STU:60601,6VT:60602 Type1,Allosteric Inactive DFGin 7.4725 14.6042 None -132.46, -37.52 -94.52, 85.46 -82.34, 16.94 281.45, 80.99 -67.49, -33.4 in-in in 9.8975 Saltbr-in 3.2515 HRD-out -71.96, 95.28 -74.85, 167.58 in-in-out SNCiio in-out ActLoopNT-in 2.8817 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -101.64, 146.06 APE9-dihe-na 119.59, 166.41 APE8-dihe-in -64.65, 139.74 APE8-rot-out 166.73 APE67-dihe-in -69.09, -28.51 -58.99, -33.91 APE12-dist-in 7.8697 APE11-dist-in 11.3589 APE10-dist-in 5.426 APE9-dist-out 6.0759 None TPO183 TPO183 XRAY 3.41 0.223 0.259 A 503.0 363.0 0 27 27 0 [[27, 279]] 1.0 5kq5 Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
STE TAOK2 TAOK2_RAT 2GCDA Q9JLS3 12 320 1235.0 STU:400 Type1 Active DFGin 7.5535 13.9109 BLAminus -132.94, -176.95 54.35, 85.93 -97.33, 11.47 293.74, 82.14 -43.28, -29.02 in-in in 8.7034 Saltbr-in 2.6655 HRD-in -73.77, -54.73 77.19, 2.76 in-in-in SNCiii in-in ActLoopNT-in 2.5835 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.82, 161.5 APE9-dihe-na 135.37, -167.85 APE8-dihe-in -112.69, 128.97 APE8-rot-in 298.27 APE67-dihe-in -60.01, -20.68 -41.39, -55.54 APE12-dist-in 9.2267 APE11-dist-in 11.1645 APE10-dist-in 5.326 APE9-dist-in 2.9408 None SEP181 SEP181 XRAY 2.55 0.203 0.261 A 309.0 309.0 0 24 24 0 [[28, 281]] 1.0 2gcd Rattus norvegicus STE_TAOK2_RAT STE 9.6e-90 306.4 2.0 257.0 256.0 168 169 170 172 174 57 76 80 148 150 149 151.0 207 192 187 186 185 184 183 182 181 106 Serine/threonine-protein kinase TAO2
STE TAOK2 TAOK2_RAT 2GCDB Q9JLS3 12 320 1235.0 STU:500 Type1 Active DFGin 7.4529 13.677 BLAminus -123.25, 173.38 55.73, 83.59 -94.3, 26.26 300.5, 83.93 -55.16, -25.83 in-in in 8.6133 Saltbr-in 3.0135 HRD-in -78.82, -57.88 82.93, 0.43 in-in-in SNCiii in-in ActLoopNT-in 2.7261 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.09, 152.57 APE9-dihe-na 123.5, -174.51 APE8-dihe-in -104.1, 125.98 APE8-rot-in 318.99 APE67-dihe-in -59.8, -23.52 -41.19, -51.52 APE12-dist-in 8.8695 APE11-dist-in 11.056 APE10-dist-in 5.7304 APE9-dist-in 3.1298 None SEP181 SEP181 XRAY 2.55 0.203 0.261 B 309.0 309.0 0 24 24 0 [[28, 281]] 1.0 2gcd Rattus norvegicus STE_TAOK2_RAT STE 9.6e-90 306.4 2.0 257.0 256.0 168 169 170 172 174 57 76 80 148 150 149 151.0 207 192 187 186 185 184 183 182 181 106 Serine/threonine-protein kinase TAO2

Ligand: STU

Total number of chains: 23
Active chains: 3
Total number of genes: 9
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 12 52.2% 4C34A
DFGin BLAminus 7 30.4% 2GCDA
DFGin None 2 8.7% 4CFHA
DFGout None 2 8.7% 3D7TB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL CTR1 CTR1_ARATH 3PPZA Q05609 540 810 821.0 STU:1 Type1 Active DFGin 7.1683 14.1759 BLAminus -141.04, 175.37 60.27, 75.13 -95.53, 20.67 299.73, 103.42 -61.37, -41.48 in-in in 9.2355 Saltbr-in 3.0989 HRD-in -68.66, -37.79 67.09, -5.56 in-in-in SNCiii in-in ActLoopNT-in 3.1696 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.6, 161.97 APE9-dihe-na 135.37, 159.66 APE8-dihe-in -74.98, 124.27 APE8-rot-in 310.73 APE67-dihe-in -59.97, -23.72 -59.94, -40.82 APE12-dist-in 7.4492 APE11-dist-in 10.7563 APE10-dist-in 6.0215 APE9-dist-in 3.9622 None TPO704,SEP707,SEP710 TPO704,SEP707,SEP710 XRAY 2.99 0.204 0.256 A 309.0 267.0 4 28 28 0 [[551, 807]] 1.0 3ppz Arabidopsis thaliana TKL_CTR1_ARATH TKL 5e-79 271.5 2.0 265.0 264.0 693 694 695 697 699 578 596 600 673 675 674 676.0 733 721 716 715 714 713 712 711 710 626 Serine/threonine-protein kinase CTR1
TKL CTR1 CTR1_ARATH 3P86A Q05609 544 810 821.0 STU:0 Type1 Inactive DFGout 11.6989 11.4173 None -88.96, 103.02 -108.84, 121.4 -126.5, 999.0 59.02, 88.01 999.0, 999.0 out-out out 11.0091 Saltbr-out 6.0815 HRD-out -107.29, 93.48 -77.8, -17.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -129.5 APE8-dihe-in -88.96, 138.18 APE8-rot-out 51.6 APE67-dihe-in -62.6, -7.91 -94.5, 4.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.4622 D676N None None XRAY 2.496 0.197 0.232 A 309.0 250.0 17 28 11 17 [[551, 807]] 1.0 3p86 Arabidopsis thaliana TKL_CTR1_ARATH TKL 3.2e-78 268.9 2.0 265.0 264.0 693 694 695 697 699 578 596 600 673 675 674 676.0 733 721 716 715 714 713 712 711 710 626 Serine/threonine-protein kinase CTR1
AGC GRK2 ARBK1_BOVIN 8JPBG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.5082 12.2136 ABAminus -113.28, -56.44 -93.74, 100.06 -93.25, 26.0 307.53, 3.55 -63.32, -43.2 in-out in 8.9334 Saltbr-out 4.2174 HRD-out -93.17, 87.64 -73.74, -9.71 out-in-in SNCoii in-in ActLoopNT-in 2.7258 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.15, 142.89 APE9-dihe-na 142.59, -152.8 APE8-dihe-in -124.3, 137.48 APE8-rot-in 299.05 APE67-dihe-inflip 90.41, -8.27 -58.8, 137.88 APE12-dist-in 9.9025 APE11-dist-in 12.0099 APE10-dist-in 6.0986 APE9-dist-in 3.6298 A292P,R295I,S455D None None EM 3.07 999.0 999.0 G 688.0 658.0 0 26 26 0 [[191, 453]] 1.0 8jpb Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 8JPCG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.385 12.1571 ABAminus -113.22, -56.58 -93.6, 101.44 -93.44, 27.48 306.81, 9.79 -63.79, -45.14 in-out in 8.9895 Saltbr-out 4.6535 HRD-out -92.62, 94.67 -75.66, -35.58 out-in-in SNCoii in-in ActLoopNT-in 2.6526 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.27, 130.92 APE9-dihe-na 162.84, -151.71 APE8-dihe-in -129.7, 130.81 APE8-rot-in 302.62 APE67-dihe-inflip 97.48, -17.5 -57.09, 134.46 APE12-dist-in 9.7132 APE11-dist-in 11.9892 APE10-dist-in 5.9887 APE9-dist-in 4.3163 A292P,R295I,S455D None None EM 3.07 999.0 999.0 G 688.0 658.0 0 26 26 0 [[191, 453]] 1.0 8jpc Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 8JPDG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.3847 12.1571 ABAminus -113.24, -56.55 -93.57, 101.39 -93.42, 27.53 306.84, 9.79 -63.78, -45.12 in-out in 8.9895 Saltbr-out 4.6534 HRD-out -92.61, 94.65 -75.65, -35.58 out-in-in SNCoii in-in ActLoopNT-in 2.6534 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.32, 130.92 APE9-dihe-na 162.83, -151.7 APE8-dihe-in -129.72, 130.82 APE8-rot-in 302.58 APE67-dihe-inflip 97.48, -17.49 -57.11, 134.43 APE12-dist-in 9.7137 APE11-dist-in 11.9887 APE10-dist-in 5.9885 APE9-dist-in 4.3171 A292P,R295I,S455D None None EM 2.81 999.0 999.0 G 688.0 658.0 0 26 26 0 [[191, 453]] 1.0 8jpd Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC PRKACA KAPCA_BOVIN 1STCE P00517 16 351 351.0 STU:60351 Type1 Inactive DFGin 6.1254 14.6764 ABAminus -152.28, -21.25 -98.94, 113.28 -112.23, 27.12 284.07, 102.64 -65.61, -29.61 in-in in 9.1737 Saltbr-in 2.6077 HRD-out -84.15, -57.61 42.07, 55.99 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.84, 156.46 APE9-dihe-na 129.45, -158.0 APE8-dihe-in -121.73, 124.56 APE8-rot-in 292.46 APE67-dihe-in -75.12, -21.46 -28.7, -46.78 APE12-dist-in 8.3869 APE11-dist-in 11.1625 APE10-dist-in 5.8257 APE9-dist-in 4.4432 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.3 0.208 0.33 E 350.0 336.0 0 25 25 0 [[44, 298]] 1.0 1stc Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 4C34A P00517 11 351 351.0 STU:61351 Type1 Inactive DFGin 6.5166 14.8494 ABAminus -119.31, -40.44 -98.64, 112.68 -107.28, 23.29 283.36, 88.13 -59.12, -19.89 in-in in 8.8642 Saltbr-in 2.9854 HRD-in -78.06, -54.1 69.84, 7.38 in-in-in SNCiii in-in ActLoopNT-in 2.9107 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.66, 162.66 APE9-dihe-na 118.12, -166.39 APE8-dihe-in -111.07, 134.19 APE8-rot-in 303.77 APE67-dihe-in -56.72, -26.94 -46.04, -52.13 APE12-dist-in 8.3983 APE11-dist-in 11.4581 APE10-dist-in 5.7648 APE9-dist-in 3.4077 F55Y,M121L,V124L,L174M,Q182K SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.78 0.18 0.214 A 351.0 340.0 0 25 25 0 [[44, 298]] 1.0 4c34 Bos taurus AGC_PRKACA_BOVIN AGC 7.8e-94 319.7 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
TYR SRC SRC_CHICK 3D7TB P00523 258 533 533.0 STU:6334 Type1 Inactive DFGout 12.8141 10.1214 None -137.48, -160.64 -79.66, 41.23 -140.31, 108.32 334.97, 53.33 120.28, -36.98 in-in in 8.0289 Saltbr-in 2.6221 HRD-in -81.72, -43.05 80.64, -35.93 in-out-none SNCion out-none ActLoopNT-out 5.4127 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 102.99 APE9-dihe-in -85.23, 141.01 APE8-dihe-in -81.53, 111.41 APE8-rot-na 348.05 APE67-dihe-in -53.4, -28.51 -45.34, -53.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.2899 APE9-dist-in 5.671 None None None XRAY 2.899 0.239 0.278 B 286.0 265.0 11 29 18 11 [[267, 518]] 1.0 3d7t Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR RTKC8 A9VBW0_MONBE 8E4TA A9VBW0 1412 1684 1911.0 STU:61901,STU:61902 Type1,Allosteric Inactive DFGin 5.7982 14.2575 BLAminus -127.66, 178.05 63.29, 82.89 -96.19, 23.12 289.39, 77.3 -56.36, -33.99 in-in in 8.0346 Saltbr-in 2.8966 HRD-in -84.2, -48.48 70.19, 15.14 in-in-out SNCiio in-out ActLoopNT-in 2.9354 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.95, 2.58 APE9-dihe-in -47.64, 117.94 APE8-dihe-in -73.3, 83.54 APE8-rot-na 25.08 APE67-dihe-in -68.63, -15.26 -57.08, -37.63 APE12-dist-na 12.1483 APE11-dist-na 14.5735 APE10-dist-na 11.1729 APE9-dist-out 8.0268 None None None XRAY 1.95 0.206 0.255 A 283.0 268.0 5 29 24 5 [[1423, 1678]] 1.0 8e4t Monosiga brevicollis TYR_RTKC8_MONBE TYR 8.9e-85 290.0 3.0 260.0 258.0 1563 1564 1565 1567 1569 1455 1472 1476 1543 1545 1544 1546.0 1604 1592 1587 1586 1585 1584 1583 1582 1581 1502 non-specific protein-tyrosine kinase
CAMK PRKAA1 AAPK1_MOUSE 5UFUA Q5EG47 20 559 559.0 STU:60601,85V:60602 Type1,Allosteric Inactive DFGin 7.217 14.2462 BLAminus -131.5, 162.6 65.85, 93.86 -99.38, 24.57 280.79, 65.36 -57.61, -46.84 in-in in 9.7642 Saltbr-in 2.7483 HRD-out -69.82, 100.36 -85.07, 166.65 in-in-out SNCiio in-out ActLoopNT-in 2.7449 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -90.3, 155.77 APE9-dihe-na 100.05, 157.58 APE8-dihe-in -52.88, 143.31 APE8-rot-out 164.19 APE67-dihe-in -65.21, -41.11 -61.15, -33.48 APE12-dist-in 7.5744 APE11-dist-in 11.0949 APE10-dist-in 5.1302 APE9-dist-out 6.066 None TPO183 TPO183 XRAY 3.45 0.195 0.238 A 503.0 249.0 0 27 27 0 [[27, 279]] 1.0 5ufu Mus musculus CAMK_PRKAA1_MOUSE CAMK 3.9e-89 304.5 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
TKL RIPK4 RIPK4_MOUSE 5WNLA Q9ERK0 10 288 786.0 STU:401 Type1 Inactive DFGin 5.3569 14.5725 BLAminus -134.03, 174.48 63.33, 81.72 -96.92, 21.29 289.3, 76.96 -59.26, -33.93 in-in in 8.7782 Saltbr-in 2.733 HRD-in -81.33, -54.8 69.56, 11.14 in-in-out SNCiio in-out ActLoopNT-in 3.066 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 144.67 APE9-dihe-na 85.9, -57.36 APE8-dihe-out -63.74, -13.96 APE8-rot-out 59.65 APE67-dihe-in -59.52, -31.71 -58.84, -41.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.6648 APE9-dist-out 11.7093 D143N None None XRAY 2.5 0.224 0.256 A 342.0 262.0 17 31 17 14 [[19, 285]] 1.0 5wnl Mus musculus TKL_RIPK4_MOUSE TKL 1.4e-74 257.0 4.0 266.0 263.0 160 161 162 164 166 51 69 73 140 142 141 143.0 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4
CAMK CDPK2 CDPK2_PLAFK 4MVFA O15865 60 511 513.0 STU:60601 Type1 Inactive DFGin 6.8149 14.4306 ABAminus -113.07, -2.16 -142.08, 130.21 -125.4, 28.29 288.94, 85.92 -61.14, -23.54 in-in in 9.4389 Saltbr-in 2.7799 HRD-in -82.17, -47.76 70.19, 0.74 in-in-none SNCiin in-none ActLoopNT-in 2.8942 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.195 0.23 A 506.0 405.0 39 27 8 19 [[72, 326]] 1.0 4mvf Plasmodium falciparum CAMK_CDPK2_PLAFK CAMK 7.5e-88 300.5 1.0 256.0 256.0 212 213 214 216 218 101 117 121 189 191 190 192.0 250 239 234 233 232 231 230 229 228 147 Calcium-dependent protein kinase 2
CAMK PRKAA1 AAPK1_RAT 6E4TA P54645 20 559 559.0 HTV:60601,STU:60602 Allosteric,Type1 Inactive DFGin 7.4354 14.2606 ABAminus -127.14, -39.21 -103.64, 92.84 -85.31, 24.03 289.4, 72.26 -73.07, -34.04 out-in out 10.0186 Saltbr-in 3.1477 HRD-out -67.59, 99.51 -83.8, 164.42 in-in-out SNCiio in-out ActLoopNT-in 2.8682 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -86.15, 147.86 APE9-dihe-na 86.15, 170.33 APE8-dihe-in -53.88, 128.36 APE8-rot-out 178.71 APE67-dihe-in -78.32, -32.83 -55.05, -15.97 APE12-dist-in 7.7373 APE11-dist-in 10.9496 APE10-dist-in 5.1078 APE9-dist-out 6.0467 None TPO183 TPO183 XRAY 3.4 0.218 0.245 A 503.0 362.0 0 27 27 0 [[27, 279]] 1.0 6e4t Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 4QFGA P54645 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.5311 14.8343 ABAminus -129.83, -31.53 -108.51, 95.59 -86.54, 22.6 280.04, 73.48 -69.33, -40.23 in-in in 8.7666 Saltbr-in 2.7784 HRD-out -72.26, 87.26 -69.37, 157.2 in-in-in SNCiii in-in ActLoopNT-in 2.8109 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.6, 162.5 APE9-dihe-na 108.84, 159.63 APE8-dihe-in -59.24, 132.89 APE8-rot-in 308.45 APE67-dihe-in -56.78, -50.62 -41.69, -48.89 APE12-dist-in 7.8041 APE11-dist-in 11.2797 APE10-dist-in 5.635 APE9-dist-in 5.9765 None TPO183 TPO183 XRAY 3.46 0.224 0.267 A 503.0 366.0 0 27 27 0 [[27, 279]] 1.0 4qfg Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 4QFRA P54645 20 559 559.0 STU:60601,32J:60606 Type1,Allosteric Inactive DFGin 7.1795 14.4615 ABAminus -135.94, -12.01 -110.66, 91.74 -85.33, 22.64 282.92, 78.98 -65.65, -45.25 in-in in 9.739 Saltbr-in 3.3805 HRD-out -83.58, 90.91 -68.37, 165.86 in-in-out SNCiio in-out ActLoopNT-in 2.9366 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -94.98, 155.0 APE9-dihe-na 104.66, 160.03 APE8-dihe-in -55.29, 137.08 APE8-rot-out 167.48 APE67-dihe-in -71.49, -40.84 -60.68, -24.54 APE12-dist-in 7.6236 APE11-dist-in 11.1612 APE10-dist-in 5.1813 APE9-dist-out 6.0551 None TPO183 TPO183 XRAY 3.34 0.212 0.249 A 503.0 362.0 0 27 27 0 [[27, 279]] 1.0 4qfr Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 4QFSA P54645 20 559 559.0 STU:60601,32H:60602 Type1,Allosteric Inactive DFGin 6.8904 14.3775 ABAminus -124.9, -28.24 -112.18, 85.76 -75.27, 7.65 284.68, 79.39 -57.92, -39.76 in-in in 9.7636 Saltbr-in 3.4673 HRD-out -68.1, 87.64 -69.41, 154.35 in-in-out SNCiio in-out ActLoopNT-in 2.903 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -125.95, 151.68 APE9-dihe-na 98.37, 158.77 APE8-dihe-in -43.48, 135.81 APE8-rot-out 168.88 APE67-dihe-in -73.46, -39.34 -64.14, -18.67 APE12-dist-in 7.7211 APE11-dist-in 11.3043 APE10-dist-in 5.5453 APE9-dist-out 6.2808 None TPO183 TPO183 XRAY 3.55 0.228 0.269 A 503.0 362.0 0 27 27 0 [[27, 279]] 1.0 4qfs Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 6E4UA P54645 20 559 559.0 STU:60601,HU7:60602 Type1,Allosteric Inactive DFGin 7.2287 14.4867 ABAminus -129.48, -32.52 -101.47, 99.32 -91.51, 18.06 282.35, 82.84 -62.17, -40.84 in-in in 9.7775 Saltbr-in 2.8999 HRD-out -78.35, 93.03 -70.69, 167.95 in-in-out SNCiio in-out ActLoopNT-in 2.9076 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -104.64, -70.24 APE9-dihe-na -62.49, -169.58 APE8-dihe-in -69.59, 137.05 APE8-rot-out 166.67 APE67-dihe-in -62.15, -31.58 -48.72, -38.44 APE12-dist-in 7.8875 APE11-dist-in 10.9362 APE10-dist-in 5.3018 APE9-dist-out 6.1152 None TPO183 TPO183 XRAY 3.27 0.213 0.231 A 503.0 366.0 0 27 27 0 [[27, 279]] 1.0 6e4u Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 6E4WA P54645 20 559 559.0 STU:60601,HUG:60602 Type1,Allosteric Inactive DFGin 7.496 14.4075 ABAminus -129.16, -43.82 -96.4, 98.46 -86.03, 19.41 285.3, 80.28 -65.13, -32.32 out-in out 10.281 Saltbr-in 3.4137 HRD-out -66.89, 97.04 -81.94, 166.54 in-in-out SNCiio in-out ActLoopNT-in 2.8853 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -119.09, -68.02 APE9-dihe-na -76.27, -164.02 APE8-dihe-in -59.87, 132.49 APE8-rot-out 168.71 APE67-dihe-in -67.7, -51.69 -45.66, -33.67 APE12-dist-in 7.7135 APE11-dist-in 10.8706 APE10-dist-in 5.4855 APE9-dist-out 6.0807 None TPO183 TPO183 XRAY 3.35 0.21 0.244 A 503.0 362.0 0 27 27 0 [[27, 279]] 1.0 6e4w Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 5T5TA P54645 20 559 559.0 STU:60601 Type1 Inactive DFGin 7.2749 14.4462 BLAminus -131.93, 169.19 62.59, 84.7 -94.86, 17.97 279.02, 73.94 -55.16, -41.28 in-in in 9.798 Saltbr-in 3.1713 HRD-out -77.74, 95.53 -76.17, 164.09 in-in-out SNCiio in-out ActLoopNT-in 2.8385 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -99.9, 148.13 APE9-dihe-na 108.52, 171.16 APE8-dihe-in -60.68, 140.01 APE8-rot-out 180.44 APE67-dihe-in -65.41, -31.73 -60.15, -34.97 APE12-dist-in 7.7967 APE11-dist-in 11.284 APE10-dist-in 5.3159 APE9-dist-out 6.2478 None TPO183 TPO183 XRAY 3.46 0.212 0.231 A 503.0 369.0 0 27 27 0 [[27, 279]] 1.0 5t5t Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 4CFHA P54645 21 481 559.0 STU:61550 Type1 Inactive DFGin 6.6088 14.765 None -117.21, -79.88 -80.17, 112.56 -105.2, 27.91 278.75, 78.83 -62.93, -29.8 in-in in 9.2938 Saltbr-in 2.6645 HRD-out -123.7, 94.84 -71.28, 163.89 in-in-out SNCiio in-out ActLoopNT-in 3.0286 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiio APE10-dihe-na -124.99, -9.44 APE9-dihe-na -61.07, -171.7 APE8-dihe-in -76.22, 167.06 APE8-rot-in 301.11 APE67-dihe-out -88.03, -177.87 -58.32, -48.27 APE12-dist-in 8.3547 APE11-dist-in 10.8638 APE10-dist-in 5.2822 APE9-dist-out 6.0779 None TPO183,TPO388 TPO183,TPO388 XRAY 3.24 0.234 0.268 A 493.0 402.0 0 27 27 0 [[27, 279]] 1.0 4cfh Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.7e-89 304.6 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 5KQ5A P54645 21 559 559.0 STU:60601,6VT:60602 Type1,Allosteric Inactive DFGin 7.4725 14.6042 None -132.46, -37.52 -94.52, 85.46 -82.34, 16.94 281.45, 80.99 -67.49, -33.4 in-in in 9.8975 Saltbr-in 3.2515 HRD-out -71.96, 95.28 -74.85, 167.58 in-in-out SNCiio in-out ActLoopNT-in 2.8817 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -101.64, 146.06 APE9-dihe-na 119.59, 166.41 APE8-dihe-in -64.65, 139.74 APE8-rot-out 166.73 APE67-dihe-in -69.09, -28.51 -58.99, -33.91 APE12-dist-in 7.8697 APE11-dist-in 11.3589 APE10-dist-in 5.426 APE9-dist-out 6.0759 None TPO183 TPO183 XRAY 3.41 0.223 0.259 A 503.0 363.0 0 27 27 0 [[27, 279]] 1.0 5kq5 Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
STE TAOK2 TAOK2_RAT 2GCDA Q9JLS3 12 320 1235.0 STU:400 Type1 Active DFGin 7.5535 13.9109 BLAminus -132.94, -176.95 54.35, 85.93 -97.33, 11.47 293.74, 82.14 -43.28, -29.02 in-in in 8.7034 Saltbr-in 2.6655 HRD-in -73.77, -54.73 77.19, 2.76 in-in-in SNCiii in-in ActLoopNT-in 2.5835 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.82, 161.5 APE9-dihe-na 135.37, -167.85 APE8-dihe-in -112.69, 128.97 APE8-rot-in 298.27 APE67-dihe-in -60.01, -20.68 -41.39, -55.54 APE12-dist-in 9.2267 APE11-dist-in 11.1645 APE10-dist-in 5.326 APE9-dist-in 2.9408 None SEP181 SEP181 XRAY 2.55 0.203 0.261 A 309.0 309.0 0 24 24 0 [[28, 281]] 1.0 2gcd Rattus norvegicus STE_TAOK2_RAT STE 9.6e-90 306.4 2.0 257.0 256.0 168 169 170 172 174 57 76 80 148 150 149 151.0 207 192 187 186 185 184 183 182 181 106 Serine/threonine-protein kinase TAO2
STE TAOK2 TAOK2_RAT 2GCDB Q9JLS3 12 320 1235.0 STU:500 Type1 Active DFGin 7.4529 13.677 BLAminus -123.25, 173.38 55.73, 83.59 -94.3, 26.26 300.5, 83.93 -55.16, -25.83 in-in in 8.6133 Saltbr-in 3.0135 HRD-in -78.82, -57.88 82.93, 0.43 in-in-in SNCiii in-in ActLoopNT-in 2.7261 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.09, 152.57 APE9-dihe-na 123.5, -174.51 APE8-dihe-in -104.1, 125.98 APE8-rot-in 318.99 APE67-dihe-in -59.8, -23.52 -41.19, -51.52 APE12-dist-in 8.8695 APE11-dist-in 11.056 APE10-dist-in 5.7304 APE9-dist-in 3.1298 None SEP181 SEP181 XRAY 2.55 0.203 0.261 B 309.0 309.0 0 24 24 0 [[28, 281]] 1.0 2gcd Rattus norvegicus STE_TAOK2_RAT STE 9.6e-90 306.4 2.0 257.0 256.0 168 169 170 172 174 57 76 80 148 150 149 151.0 207 192 187 186 185 184 183 182 181 106 Serine/threonine-protein kinase TAO2