Ligand: STU (Staurosporine)

Total number of chains: 108
Active chains: 28
Total number of genes: 39
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 64 59.3% 5E8XA
DFGin None 17 15.7% 6B1UA
DFGin ABAminus 9 8.3% 3LCSA
DFGin BLBplus 6 5.6% 7NVQA
DFGin BLBminus 4 3.7% 4EZ7A
None None 4 3.7% 3FMEA
DFGinter BABtrans 3 2.8% 2CLQA
DFGin BLAplus 1 0.9% 5LOHA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC MASTL GWL_HUMAN 5LOHA Q96GX5 30 854 879.0 STU:60901 Type1 Inactive DFGin 10.84 13.519 BLAplus -154.04, -179.93 62.84, 37.43 -106.51, -23.39 59.72, 80.58 -168.74, -25.48 none-none none 999.0 Saltbr-none 999.0 HRD-in -59.31, -45.76 66.7, 4.42 none-out-out SNCnoo out-out ActLoopNT-out 8.33 ActLoopCT-out nonTYR APEdihe_aanon APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 165.16 APE8-dihe-none -79.14, 999.0 APE8-rot-out 44.79 APE67-dihe-none -72.42, -27.62 999.0, 33.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.891 None None None XRAY 3.1 0.209 0.265 A 341 246 34 0 0 15 [[35, 835]] 1.0 5loh AGC_MASTL_HUMAN AGC 4e-131 441.8 1 260 260 173 174 175 177 179 62 81 85 153 155 154 156 760 201 196 195 741 740 -9999 -9999 -9999 111 Serine/threonine-protein kinase greatwall
AGC MASTL GWL_HUMAN 5LOHB Q96GX5 30 854 879.0 STU:60901 Type1 Inactive None 999.0 13.339 None -152.85, -174.25 66.27, 69.27 -150.61, -21.46 41.33, 82.81 -90.34, 22.29 none-none none 999.0 Saltbr-none 999.0 HRD-in -60.11, -44.59 64.53, 4.15 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aannn APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -141.8 APE8-dihe-none -77.31, 999.0 APE8-rot-none 999.0 APE67-dihe-none 49.84, -65.93 999.0, -82.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.713 None None None XRAY 3.1 0.209 0.265 B 341 250 30 0 0 17 [[35, 835]] 1.0 5loh AGC_MASTL_HUMAN AGC 4e-131 441.8 1 260 260 173 174 175 177 179 62 81 85 153 155 154 156 760 201 196 195 741 740 -9999 -9999 -9999 111 Serine/threonine-protein kinase greatwall
AGC PDPK1 PDPK1_HUMAN 1OKYA O15530 72 360 556.0 STU:1368 Type1 Inactive DFGin 6.153 14.462 BLAminus -148.97, -170.84 70.56, 80.45 -102.75, 23.82 286.84, 96.04 -69.28, -20.21 in-in in 8.672 Saltbr-in 2.673 HRD-in -67.69, -57.78 80.28, 0.43 in-in-out SNCiio in-out ActLoopNT-in 2.934 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.7, -80.59 APE9-dihe-na 115.49, 169.91 APE8-dihe-in -54.49, 123.73 APE8-rot-in 316.76 APE67-dihe-in -63.35, -17.55 -42.07, -50.54 APE12-dist-in 9.289 APE11-dist-out 5.556 APE10-dist-out 9.719 APE9-dist-in 4.222 None SEP241 SEP241 XRAY 2.3 0.219 0.255 A 310 283 6 0 0 6 [[82, 342]] 1.0 1oky AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PRKCQ KPCT_HUMAN 1XJDA Q04759 377 696 706.0 STU:200 Type1 Active DFGin 5.828 13.193 BLAminus -132.69, 162.8 69.28, 95.13 -109.8, 21.13 305.67, 104.94 -64.79, -17.76 in-in in 8.064 Saltbr-in 2.513 HRD-in -67.27, -48.59 64.56, -1.72 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.73, 166.78 APE9-dihe-na 120.3, 163.8 APE8-dihe-in -75.86, 125.98 APE8-rot-in 298.87 APE67-dihe-in -57.15, -29.94 -38.43, -48.34 APE12-dist-in 9.03 APE11-dist-in 12.294 APE10-dist-in 6.896 APE9-dist-in 3.767 None TPO538,SEP695 TPO538,SEP695 XRAY 2.0 0.201 0.216 A 345 282 0 0 0 0 [[380, 634]] 1.0 1xjd AGC_PRKCQ_HUMAN AGC 1.2e-95 325.5 1 260 260 521 522 523 525 527 409 428 432 501 503 502 504 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC RPS6KA1-1 KS6A1_HUMAN 2Z7RA Q15418 53 340 735.0 STU:1 Type1 Inactive DFGin 6.928 12.322 BLBplus -135.18, 169.76 58.7, 61.01 -129.8, -169.31 56.27, 83.01 123.62, -72.1 none-none none 999.0 Saltbr-none 999.0 HRD-out -70.75, 75.42 -55.39, -34.53 none-out-out SNCnoo out-out ActLoopNT-out 7.378 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.4 APE8-dihe-in -65.4, 109.6 APE8-rot-in 309.27 APE67-dihe-in -55.68, -21.45 -56.7, -41.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.754 None None None XRAY 2.0 0.255 0.286 A 321 265 23 0 0 12 [[62, 321], [418, 675]] 2.0 2z7r AGC_RPS6KA1-1_HUMAN AGC 1.5e-95 325.1 1 260 260 204 205 206 208 210 94 112 116 184 186 185 187 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
AGC RPS6KB1 KS6B1_HUMAN 3A62A P23443 85 372 525.0 STU:400 Type1 Inactive DFGin 6.524 14.117 ABAminus -137.83, -32.54 -98.98, 101.69 -111.0, 24.18 305.63, 93.27 -75.95, -178.42 in-in in 8.238 Saltbr-in 2.912 HRD-in -88.81, -24.52 69.43, -47.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -65.23, -49.64 APE9-dihe-na -102.67, -164.37 APE8-dihe-in -63.46, 142.22 APE8-rot-out 175.82 APE67-dihe-in -68.79, -14.76 -111.61, 8.72 APE12-dist-in 10.247 APE11-dist-in 13.136 APE10-dist-out 9.309 APE9-dist-out 11.608 None TPO252 TPO252 XRAY 2.35 0.229 0.272 A 327 264 24 0 0 10 [[91, 352]] 1.0 3a62 AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A60A P23443 85 371 525.0 STU:400 Type1 Inactive DFGin 6.157 13.694 None -106.91, -67.93 -78.35, 124.27 -119.68, -133.11 293.51, 79.75 162.78, -54.12 in-out in 7.754 Saltbr-out 3.905 HRD-in -63.83, -43.18 73.78, -30.83 out-out-none SNCoon out-none ActLoopNT-out 3.673 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -74.9 APE8-rot-in 297.46 APE67-dihe-in -54.54, -22.69 -86.47, -11.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.21 0.268 A 327 263 24 0 0 13 [[91, 352]] 1.0 3a60 AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A61A P23443 87 371 525.0 STU:400 Type1 Inactive DFGin 5.812 13.405 None -134.05, -75.4 -81.48, 111.28 -98.21, -179.91 302.65, 80.45 -119.91, 999.0 in-in in 7.863 Saltbr-in 3.459 HRD-in -91.01, -26.19 64.38, -56.51 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -70.31 APE8-dihe-in -167.04, 106.84 APE8-rot-out 166.31 APE67-dihe-in -54.66, 20.97 -86.85, -22.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.963 None None None XRAY 3.43 0.274 0.349 A 327 254 31 0 0 16 [[91, 352]] 1.0 3a61 AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 4RLOB P23443 85 372 525.0 STU:401 Type1 Inactive None 999.0 7.196 None -86.75, 160.35 -107.62, 22.98 -156.62, 162.78 69.29, 88.54 159.5, 162.01 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.31, -49.02 69.03, -42.5 none-out-out SNCnoo out-out ActLoopNT-out 4.816 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 152.17 APE8-rot-out 189.44 APE67-dihe-in -65.44, -8.07 -124.54, 4.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.527 0.193 0.222 B 288 254 34 0 0 11 [[91, 352]] 1.0 4rlo AGC_RPS6KB1_HUMAN AGC 2.9e-96 327.5 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A60B P23443 85 372 525.0 STU:401 Type1 Inactive None 999.0 9.181 None -122.3, -155.7 -144.9, 63.43 -46.62, 179.79 231.81, 121.03 -99.91, 37.09 none-none none 999.0 Saltbr-none 999.0 HRD-in -85.46, -48.18 73.35, -54.05 none-in-out SNCnio in-out ActLoopNT-in 2.865 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -2.69 APE9-dihe-na -82.95, -88.68 APE8-dihe-in -146.72, 128.75 APE8-rot-out 80.81 APE67-dihe-in -72.02, 1.17 -100.99, 0.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 29.777 APE9-dist-out 31.967 None None None XRAY 2.8 0.21 0.268 B 327 255 33 0 0 10 [[91, 352]] 1.0 3a60 AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC STK32A ST32A_HUMAN 4FR4A Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 6.958 14.55 BLAminus -131.26, -171.36 55.81, 77.24 -91.39, 23.54 282.26, 68.76 -52.72, -37.5 in-out in 9.45 Saltbr-out 4.405 HRD-in -80.59, -48.19 75.72, 1.95 out-in-in SNCoii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.54, 125.66 APE9-dihe-na 163.36, -179.6 APE8-dihe-in -98.31, 118.28 APE8-rot-in 302.74 APE67-dihe-in -69.16, -7.09 -58.36, -42.03 APE12-dist-in 9.984 APE11-dist-in 11.7 APE10-dist-in 6.037 APE9-dist-in 3.577 None None None XRAY 2.29 0.206 0.244 A 384 350 0 0 0 0 [[23, 281]] 1.0 4fr4 AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4B Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 7.004 14.665 BLAminus -130.94, -173.3 57.57, 78.46 -91.73, 35.47 281.68, 71.64 -62.72, -37.53 in-out in 9.523 Saltbr-out 4.678 HRD-in -83.22, -47.99 75.33, -2.43 out-in-in SNCoii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.47, 130.4 APE9-dihe-na 159.4, 177.51 APE8-dihe-in -93.68, 119.81 APE8-rot-in 304.76 APE67-dihe-in -71.88, -7.25 -60.98, -38.06 APE12-dist-in 10.024 APE11-dist-in 11.735 APE10-dist-in 6.019 APE9-dist-in 3.57 None None None XRAY 2.29 0.206 0.244 B 384 350 0 0 0 0 [[23, 281]] 1.0 4fr4 AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4C Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 6.95 14.697 BLAminus -132.52, -169.93 52.69, 78.95 -90.58, 33.35 282.07, 69.09 -66.67, -30.48 in-out in 9.538 Saltbr-out 4.652 HRD-in -81.16, -46.81 73.79, 0.59 out-in-in SNCoii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.08, 126.04 APE9-dihe-na 163.32, 177.32 APE8-dihe-in -92.37, 117.65 APE8-rot-in 306.61 APE67-dihe-in -71.09, -9.62 -57.49, -40.3 APE12-dist-in 9.986 APE11-dist-in 11.719 APE10-dist-in 6.031 APE9-dist-in 3.569 None None None XRAY 2.29 0.206 0.244 C 384 344 0 0 0 0 [[23, 281]] 1.0 4fr4 AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4D Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 6.968 14.54 BLAminus -131.99, -171.7 54.78, 77.72 -90.01, 30.97 282.82, 68.36 -59.09, -35.1 in-out in 9.54 Saltbr-out 4.111 HRD-in -82.23, -46.79 74.71, 0.05 out-in-in SNCoii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.67, 126.06 APE9-dihe-na 163.38, 179.82 APE8-dihe-in -95.08, 119.14 APE8-rot-in 303.5 APE67-dihe-in -68.68, -8.82 -58.5, -42.47 APE12-dist-in 10.028 APE11-dist-in 11.674 APE10-dist-in 5.978 APE9-dist-in 3.621 None None None XRAY 2.29 0.206 0.244 D 384 346 0 0 0 0 [[23, 281]] 1.0 4fr4 AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4E Q8WU08 14 372 396.0 STU:401 Type1 Inactive DFGin 6.929 14.69 BLAminus -131.82, -175.27 57.96, 79.76 -93.48, 35.37 282.42, 66.15 -67.02, -30.68 in-out in 9.559 Saltbr-out 4.667 HRD-in -80.84, -48.94 74.6, -0.56 out-in-in SNCoii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.84, 126.86 APE9-dihe-na 161.76, 179.6 APE8-dihe-in -94.71, 118.0 APE8-rot-in 302.52 APE67-dihe-in -65.82, -9.98 -56.35, -43.97 APE12-dist-in 10.033 APE11-dist-in 11.753 APE10-dist-in 6.011 APE9-dist-in 3.555 None None None XRAY 2.29 0.206 0.244 E 384 342 0 0 0 0 [[23, 281]] 1.0 4fr4 AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4F Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 6.922 14.48 BLAminus -133.24, -172.46 54.73, 79.35 -94.14, 35.98 283.65, 67.48 -61.74, -33.87 in-out in 9.458 Saltbr-out 4.459 HRD-in -80.63, -46.14 70.35, 4.86 out-in-in SNCoii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.84, 129.22 APE9-dihe-na 160.43, 179.28 APE8-dihe-in -96.01, 118.11 APE8-rot-in 307.21 APE67-dihe-in -68.52, -8.52 -57.81, -41.21 APE12-dist-in 10.007 APE11-dist-in 11.703 APE10-dist-in 5.986 APE9-dist-in 3.587 None None None XRAY 2.29 0.206 0.244 F 384 346 0 0 0 0 [[23, 281]] 1.0 4fr4 AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
CAMK CHEK1 CHK1_HUMAN 1NVRA O14757 3 273 476.0 STU:400 Type1 Active DFGin 7.007 14.466 BLAminus -138.12, 170.91 63.58, 88.44 -97.82, 26.51 284.37, 82.9 -65.94, -21.37 in-in in 8.834 Saltbr-in 3.325 HRD-in -77.73, -42.26 72.42, 0.07 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.96, 168.99 APE9-dihe-na 123.47, -148.6 APE8-dihe-in -135.84, 118.76 APE8-rot-in 301.9 APE67-dihe-in -60.54, -22.99 -38.52, -52.15 APE12-dist-in 8.986 APE11-dist-in 11.773 APE10-dist-in 6.22 APE9-dist-in 3.344 None None None XRAY 1.8 0.193 0.226 A 289 264 7 0 0 0 [[9, 265]] 1.0 1nvr CAMK_CHEK1_HUMAN CAMK 2.6e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7AKOA O14757 2 271 476.0 STU:60301 Type1 Active DFGin 7.258 14.346 BLAminus -129.99, 164.38 63.12, 90.57 -95.99, 30.1 286.66, 77.28 -66.31, -26.96 in-in in 8.834 Saltbr-in 2.687 HRD-in -79.3, -45.9 76.54, 2.66 in-in-in SNCiii in-in ActLoopNT-in 2.999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.15, 172.04 APE9-dihe-na 107.34, -156.22 APE8-dihe-in -136.58, 123.75 APE8-rot-in 305.71 APE67-dihe-in -59.04, -20.83 -49.6, -50.22 APE12-dist-in 8.951 APE11-dist-in 11.921 APE10-dist-in 6.385 APE9-dist-in 3.572 D10R None None XRAY 1.8 0.192 0.235 A 300 270 0 0 0 0 [[9, 265]] 1.0 7ako CAMK_CHEK1_HUMAN CAMK 3.4e-71 245.5 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7AKOB O14757 2 271 476.0 STU:60301 Type1 Active DFGin 7.037 14.527 BLAminus -133.06, 166.86 60.65, 91.44 -101.1, 26.21 287.91, 78.35 -62.72, -24.94 in-in in 9.183 Saltbr-in 3.404 HRD-in -77.35, -44.25 76.09, 6.63 in-in-in SNCiii in-in ActLoopNT-in 3.039 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.79, 168.24 APE9-dihe-na 123.14, -149.89 APE8-dihe-in -132.89, 126.1 APE8-rot-in 304.27 APE67-dihe-in -62.82, -10.87 -52.63, -48.98 APE12-dist-in 8.63 APE11-dist-in 11.884 APE10-dist-in 6.247 APE9-dist-in 3.495 D10R None None XRAY 1.8 0.192 0.235 B 300 270 0 0 0 0 [[9, 265]] 1.0 7ako CAMK_CHEK1_HUMAN CAMK 3.4e-71 245.5 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5OORA O14757 3 283 476.0 STU:301 Type1 Inactive DFGin 7.196 13.603 BLAminus -121.08, 157.07 78.53, 94.76 -101.65, 21.08 291.71, 78.34 -70.5, -20.28 in-out in 9.325 Saltbr-out 5.381 HRD-in -78.63, -43.76 73.29, -4.94 out-in-in SNCoii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.81, 173.83 APE9-dihe-na 115.52, -146.73 APE8-dihe-in -140.31, 116.76 APE8-rot-in 299.43 APE67-dihe-in -68.59, -17.99 -48.27, -41.97 APE12-dist-in 9.154 APE11-dist-in 11.744 APE10-dist-in 6.296 APE9-dist-in 3.597 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.9 0.167 0.208 A 297 273 8 0 0 0 [[9, 265]] 1.0 5oor CAMK_CHEK1_HUMAN CAMK 4.8e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK DAPK1 DAPK1_HUMAN 1WVYA P53355 4 276 1430.0 STU:1001 Type1 Inactive DFGin 6.742 14.293 ABAminus -89.35, -23.12 -108.72, 148.84 -138.39, 21.2 279.12, 93.85 -56.2, -46.66 in-in in 9.453 Saltbr-in 2.791 HRD-in -70.14, -42.49 63.36, 7.4 in-in-out SNCiio in-out ActLoopNT-in 2.757 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -134.32, 148.67 APE9-dihe-na -105.19, -133.62 APE8-dihe-in -62.12, 122.93 APE8-rot-in 303.72 APE67-dihe-in -56.52, -27.75 -50.01, -41.98 APE12-dist-in 10.349 APE11-dist-out 5.638 APE10-dist-out 8.762 APE9-dist-in 4.974 None None None XRAY 2.8 0.222 0.274 A 278 273 0 0 0 0 [[13, 275]] 1.0 1wvy CAMK_DAPK1_HUMAN CAMK 5e-95 323.6 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK MAPKAPK2 MAPK2_HUMAN 2PZYC P49137 42 359 400.0 STU:3 Type1 None DFGin 4.742 13.584 BLAminus -137.32, 155.33 89.76, 83.85 -93.67, 22.39 287.9, 52.26 -71.67, 3.21 in-in in 8.899 Saltbr-in 2.479 HRD-in -82.26, -44.82 71.63, -15.61 in-in-none SNCiin in-none ActLoopNT-in 2.823 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -81.01, -7.47 999.0, -140.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.251 0.313 C 324 307 11 0 0 11 [[63, 325]] 1.0 2pzy CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKA P49137 42 345 400.0 STU:401 Type1 None DFGin 4.829 13.428 BLAminus -122.05, -170.73 42.15, 101.84 -103.58, 19.28 282.18, 65.24 -58.03, -23.15 in-in in 8.716 Saltbr-in 2.473 HRD-in -79.4, -39.47 62.13, 0.83 in-in-none SNCiin in-none ActLoopNT-in 2.683 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -71.16, 3.04 999.0, 148.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 A 400 290 14 0 0 11 [[63, 325]] 1.0 1nxk CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKB P49137 44 345 400.0 STU:403 Type1 None DFGin 4.577 13.822 BLAminus -128.27, 177.79 53.09, 103.0 -104.87, 20.3 276.49, 67.38 -57.0, -14.43 in-in in 8.647 Saltbr-in 2.563 HRD-in -64.22, -46.2 66.47, 1.25 in-in-none SNCiin in-none ActLoopNT-in 2.82 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.0, -19.87 999.0, 111.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 B 400 283 19 0 0 11 [[63, 325]] 1.0 1nxk CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKC P49137 41 357 400.0 STU:401 Type1 None DFGin 4.963 13.774 BLAminus -132.89, 178.15 57.47, 93.76 -100.34, 25.49 283.43, 65.32 -70.88, 11.4 in-in in 8.684 Saltbr-in 2.34 HRD-in -75.36, -47.72 65.17, 8.17 in-in-none SNCiin in-none ActLoopNT-in 2.982 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.28, 2.34 999.0, 115.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 C 400 306 11 0 0 11 [[63, 325]] 1.0 1nxk CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKD P49137 43 342 400.0 STU:401 Type1 Inactive DFGin 4.831 13.91 BLAminus -136.01, 172.45 58.97, 96.18 -97.02, 30.62 280.59, 64.96 -55.97, -37.81 in-in in 8.803 Saltbr-in 2.649 HRD-in -61.55, -54.52 76.31, -8.43 in-in-out SNCiio in-out ActLoopNT-in 3.004 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, 21.79 APE9-dihe-na -95.93, -89.71 APE8-dihe-out 87.4, 89.72 APE8-rot-in 304.66 APE67-dihe-out -57.06, -12.13 -63.98, 136.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 30.487 APE9-dist-out 33.331 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 D 400 288 12 0 0 8 [[63, 325]] 1.0 1nxk CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MKNK2 MKNK2_HUMAN 2HW7A Q9HBH9 72 371 465.0 STU:60031 Type1 Inactive DFGin 4.905 14.123 BLBplus -153.19, 172.78 68.05, 27.15 -77.7, 175.81 23.89, 67.82 81.52, 999.0 in-in in 8.993 Saltbr-in 2.903 HRD-in -73.6, -55.95 77.37, -18.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 26.54 APE8-dihe-out -84.42, -14.4 APE8-rot-in 301.04 APE67-dihe-in -61.16, -21.76 -49.65, -47.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 33.47 D228G None None XRAY 2.71 0.203 0.246 A 316 269 31 0 0 23 [[83, 368]] 1.0 2hw7 CAMK_MKNK2_HUMAN CAMK 8e-79 270.5 1 256 256 225 226 227 229 231 113 129 133 202 204 203 205 277 260 255 254 253 252 251 250 249 160 MAP kinase-interacting serine/threonine-protein kinase 2
CAMK PIM1 PIM1_HUMAN 1YHSA P11309 33 305 313.0 STU:306 Type1 Active DFGin 6.361 14.512 BLAminus -129.35, 165.16 65.09, 87.92 -99.2, 21.71 283.47, 69.45 -67.38, -11.76 in-in in 8.524 Saltbr-in 2.899 HRD-na-A -65.05, -49.56 68.79, 3.6 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.4, 26.1 APE9-dihe-na -84.03, -156.82 APE8-dihe-in -85.78, 122.63 APE8-rot-in 304.34 APE67-dihe-in -62.69, -6.01 -56.85, -49.38 APE12-dist-in 9.327 APE11-dist-in 8.52 APE10-dist-in 5.508 APE9-dist-in 3.832 None SEP261 CME161,SEP261 XRAY 2.15 0.233 0.233 A 273 269 4 0 0 0 [[38, 290]] 1.0 1yhs CAMK_PIM1_HUMAN CAMK 2.4e-65 226.3 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PRKAA1 AAPK1_HUMAN 6C9FA Q13131 22 558 559.0 R34:60601,STU:60602 Allosteric,Type1 Inactive DFGin 6.728 14.295 ABAminus -116.49, -61.55 -94.26, 110.71 -99.52, 6.4 287.66, 85.72 -50.13, -39.13 out-out out 10.713 Saltbr-out 5.319 HRD-in -66.33, -58.11 53.99, 16.31 out-in-out SNCoio in-out ActLoopNT-in 2.771 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.89, 155.28 APE9-dihe-na 94.11, 171.31 APE8-dihe-in -69.7, 144.51 APE8-rot-out 175.9 APE67-dihe-in -64.59, -37.19 -54.17, -35.84 APE12-dist-in 8.268 APE11-dist-in 10.73 APE10-dist-in 5.149 APE9-dist-in 4.237 None TPO183 TPO183 XRAY 2.924 0.229 0.245 A 494 371 0 0 0 0 [[27, 279]] 1.0 6c9f CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 6C9GA Q13131 22 558 559.0 R93:60601,STU:60602 Allosteric,Type1 Inactive DFGin 6.907 14.399 BLAminus -135.02, 170.21 60.34, 77.63 -85.45, 11.43 285.05, 75.57 -50.8, -32.37 out-out out 10.695 Saltbr-out 5.597 HRD-in -79.11, -48.44 68.49, -16.14 out-in-out SNCoio in-out ActLoopNT-in 2.877 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -145.15, 158.83 APE9-dihe-na 72.57, 174.42 APE8-dihe-in -69.04, 143.86 APE8-rot-out 162.73 APE67-dihe-in -62.81, -32.14 -55.18, -38.62 APE12-dist-in 8.45 APE11-dist-in 11.031 APE10-dist-in 6.008 APE9-dist-in 4.009 None TPO183 TPO183 XRAY 2.7 0.205 0.24 A 494 384 0 0 0 0 [[27, 279]] 1.0 6c9g CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 6C9HA Q13131 22 558 559.0 R34:60601,STU:60602 Allosteric,Type1 Inactive DFGin 6.712 14.382 BLAminus -138.26, 171.2 60.5, 73.75 -84.01, 6.76 285.61, 85.73 -48.49, -36.53 out-out out 10.649 Saltbr-out 5.631 HRD-in -69.22, -48.97 68.92, -5.29 out-in-out SNCoio in-out ActLoopNT-in 3.017 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -142.6, 158.62 APE9-dihe-na 60.32, -132.0 APE8-dihe-in -130.57, 153.41 APE8-rot-out 177.79 APE67-dihe-in -63.0, -34.49 -63.07, -41.05 APE12-dist-in 8.655 APE11-dist-in 10.618 APE10-dist-in 6.189 APE9-dist-in 3.873 None None None XRAY 2.65 0.215 0.242 A 494 433 0 0 0 0 [[27, 279]] 1.0 6c9h CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 6C9JA Q13131 22 559 559.0 R34:60601,STU:60602 Allosteric,Type1 Active DFGin 6.98 13.932 BLAminus -148.31, -179.86 61.68, 68.06 -82.96, 8.26 285.07, 89.54 -49.65, -37.12 out-in out 10.05 Saltbr-in 3.025 HRD-in -61.18, -61.45 68.18, -7.34 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.03, 155.55 APE9-dihe-na 81.79, 170.06 APE8-dihe-in -65.93, 140.22 APE8-rot-in 298.24 APE67-dihe-in -65.83, -31.14 -52.06, -38.38 APE12-dist-in 8.312 APE11-dist-in 11.199 APE10-dist-in 5.64 APE9-dist-in 4.101 None TPO183 TPO183 XRAY 3.05 0.215 0.225 A 494 384 0 0 0 0 [[27, 279]] 1.0 6c9j CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 4RERA Q13131 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.724 14.682 None -104.41, -74.44 -70.58, 123.21 -111.45, 7.12 271.34, 95.59 -64.34, -25.66 in-in in 9.394 Saltbr-in 3.168 HRD-out -106.73, 104.09 -76.93, -37.65 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.23, 162.43 APE9-dihe-na 109.76, -176.61 APE8-dihe-in -65.38, 159.16 APE8-rot-in 282.67 APE67-dihe-in -82.84, -28.7 -67.98, -40.26 APE12-dist-in 8.764 APE11-dist-in 11.102 APE10-dist-in 5.353 APE9-dist-in 4.566 E480G,E483A,K485A TPO183 TPO183 XRAY 4.047 0.227 0.26 A 540 459 0 0 0 0 [[27, 279]] 1.0 4rer CAMK_PRKAA1_HUMAN CAMK 8.5e-89 303.4 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 4REWA Q13131 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.282 14.445 None -106.98, -78.3 -79.98, 116.66 -98.66, 4.74 266.69, 106.69 -52.57, -49.44 out-out out 10.894 Saltbr-out 4.849 HRD-out -91.4, 104.28 -79.59, -35.51 out-in-out SNCoio in-out ActLoopNT-in 2.949 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -146.3, 177.71 APE9-dihe-na 92.22, 179.97 APE8-dihe-in -62.77, 176.84 APE8-rot-in 309.53 APE67-dihe-in -79.73, -37.36 -85.43, -26.86 APE12-dist-in 9.032 APE11-dist-in 10.912 APE10-dist-in 6.074 APE9-dist-out 7.166 E480G,E483A,K485A None None XRAY 4.58 0.234 0.259 A 540 411 0 0 0 0 [[27, 279]] 1.0 4rew CAMK_PRKAA1_HUMAN CAMK 8.5e-89 303.4 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA2 AAPK2_HUMAN 5ISOA P54646 9 551 552.0 STU:601,992:602 Type1,Allosteric Inactive DFGin 7.076 13.754 ABAminus -124.01, -69.61 -91.71, 113.8 -98.34, 8.3 284.02, 83.8 -52.09, -32.8 out-none out 10.676 Saltbr-none 999.0 HRD-in -77.82, -48.64 73.79, -15.56 none-in-out SNCnio in-out ActLoopNT-in 3.07 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -153.96, 161.46 APE9-dihe-na 108.89, 175.81 APE8-dihe-in -73.92, 127.97 APE8-rot-out 47.66 APE67-dihe-in -62.08, -29.52 -54.52, -36.25 APE12-dist-in 8.114 APE11-dist-in 11.355 APE10-dist-in 6.596 APE9-dist-in 5.039 None None None XRAY 2.63 0.18 0.23 A 552 453 0 0 0 0 [[16, 268]] 1.0 5iso CAMK_PRKAA2_HUMAN CAMK 1.1e-89 306.3 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5ISOC P54646 9 550 552.0 STU:601,992:602 Type1,Allosteric Inactive DFGin 7.185 14.12 ABAminus -118.95, -64.95 -97.93, 114.29 -100.77, 6.08 282.8, 83.31 -57.51, -20.09 out-none out 10.921 Saltbr-none 999.0 HRD-in -73.97, -50.71 73.94, -15.38 none-in-out SNCnio in-out ActLoopNT-in 3.026 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.17, 145.11 APE9-dihe-na 105.06, -178.93 APE8-dihe-in -75.45, 134.7 APE8-rot-out 182.56 APE67-dihe-in -57.91, -29.21 -54.57, -40.7 APE12-dist-in 9.015 APE11-dist-in 11.223 APE10-dist-in 5.424 APE9-dist-in 4.301 None None None XRAY 2.63 0.18 0.23 C 552 429 0 0 0 0 [[16, 268]] 1.0 5iso CAMK_PRKAA2_HUMAN CAMK 1.1e-89 306.3 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 6B1UC P54646 9 552 552.0 STU:60601,CG7:60602 Type1,Allosteric Inactive DFGin 7.452 14.13 ABAminus -133.95, -50.46 -79.36, 100.93 -96.81, 22.67 283.51, 87.03 -67.96, -35.6 out-out out 10.247 Saltbr-out 4.344 HRD-in -62.69, -52.12 64.78, 6.12 out-in-out SNCoio in-out ActLoopNT-in 3.031 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 59.85, -130.04 APE9-dihe-na -84.76, -170.01 APE8-dihe-in -60.51, 139.79 APE8-rot-out 157.81 APE67-dihe-in -64.49, -24.93 -66.94, -29.94 APE12-dist-in 7.802 APE11-dist-in 10.102 APE10-dist-in 6.076 APE9-dist-in 4.423 None TPO172 TPO172 XRAY 2.77 0.196 0.226 C 565 460 0 0 0 0 [[16, 268]] 1.0 6b1u CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFFA P54646 8 551 552.0 STU:61552 Type1 Inactive DFGin 7.056 14.082 BLAminus -149.77, 179.95 57.3, 81.92 -95.29, 37.99 289.6, 92.87 -75.43, -19.2 out-out out 10.989 Saltbr-out 5.616 HRD-out -79.02, 102.38 -90.23, 5.49 out-in-out SNCoio in-out ActLoopNT-in 3.106 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -140.4, 154.3 APE9-dihe-na 120.73, -179.28 APE8-dihe-in -68.72, 155.02 APE8-rot-out 179.49 APE67-dihe-out -92.39, 175.4 -57.6, -33.75 APE12-dist-in 7.952 APE11-dist-in 11.177 APE10-dist-in 5.554 APE9-dist-in 3.902 None TPO172 TPO172 XRAY 3.924 0.211 0.264 A 571 425 0 0 0 0 [[16, 268]] 1.0 4cff CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 8BIKA P54646 8 551 552.0 STU:61001,QTN:61002 Type1,Allosteric Inactive DFGin 7.411 14.137 BLAminus -139.87, 175.04 60.92, 88.41 -94.92, 18.04 278.75, 87.35 -59.01, -34.32 out-in out 10.174 Saltbr-in 2.877 HRD-in -67.48, -51.05 72.2, -5.59 in-in-out SNCiio in-out ActLoopNT-in 3.029 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.52, 150.63 APE9-dihe-na 107.16, 178.8 APE8-dihe-in -62.54, 134.22 APE8-rot-out 175.32 APE67-dihe-in -59.81, -28.17 -63.52, -36.76 APE12-dist-in 7.779 APE11-dist-in 11.439 APE10-dist-in 5.768 APE9-dist-in 4.246 None None None XRAY 2.5 0.183 0.215 A 559 451 0 0 0 0 [[16, 268]] 1.0 8bik CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 8BIKD P54646 9 551 552.0 STU:61001,QTN:61002 Type1,Allosteric Inactive DFGin 7.384 14.445 BLAminus -141.24, 172.63 63.28, 83.56 -89.35, 21.67 278.42, 85.15 -58.54, -35.7 out-in out 10.175 Saltbr-in 2.805 HRD-in -67.72, -52.05 72.56, -5.24 in-in-out SNCiio in-out ActLoopNT-in 3.039 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -138.07, 151.38 APE9-dihe-na 109.6, 178.13 APE8-dihe-in -63.22, 133.31 APE8-rot-out 174.24 APE67-dihe-in -63.88, -27.23 -63.0, -33.55 APE12-dist-in 7.808 APE11-dist-in 11.338 APE10-dist-in 5.694 APE9-dist-in 4.224 None None None XRAY 2.5 0.183 0.215 D 559 443 0 0 0 0 [[16, 268]] 1.0 8bik CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 6B2EA P54646 9 551 552.0 STU:60601,CG7:60602 Type1,Allosteric Inactive DFGin 6.836 14.675 BLAminus -127.75, -179.24 60.25, 73.12 -88.18, 14.06 273.69, 88.23 -67.6, -15.67 out-none out 10.002 Saltbr-none 999.0 HRD-out -78.51, 91.55 -68.49, -19.81 none-in-out SNCnio in-out ActLoopNT-in 3.123 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiio APE10-dihe-na -70.16, 148.6 APE9-dihe-na -63.35, -41.66 APE8-dihe-in -61.85, 118.31 APE8-rot-out 58.89 APE67-dihe-out -81.11, 165.06 -67.04, -35.27 APE12-dist-in 8.467 APE11-dist-in 10.8 APE10-dist-in 6.939 APE9-dist-out 8.497 None TPO172 TPO172 XRAY 3.8 0.246 0.277 A 565 443 0 0 0 0 [[16, 268]] 1.0 6b2e CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFEA P54646 8 551 552.0 STU:61552,992:61553 Type1,Allosteric Inactive DFGin 7.08 14.072 BLAminus -145.68, 179.18 60.7, 83.63 -96.97, 26.73 284.08, 87.71 -65.51, -24.73 out-out out 10.728 Saltbr-out 5.354 HRD-out -86.27, 102.77 -89.89, 0.95 out-in-out SNCoio in-out ActLoopNT-in 3.112 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -129.79, 163.12 APE9-dihe-na 115.46, -178.56 APE8-dihe-in -67.55, 156.43 APE8-rot-out 179.35 APE67-dihe-out -75.24, 179.33 -55.61, -52.75 APE12-dist-in 7.832 APE11-dist-in 11.182 APE10-dist-in 5.502 APE9-dist-in 4.035 None TPO172 TPO172 XRAY 3.023 0.219 0.253 A 571 426 0 0 0 0 [[16, 268]] 1.0 4cfe CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFEC P54646 10 551 552.0 STU:61552,992:61553 Type1,Allosteric Inactive DFGin 6.788 14.041 BLAminus -149.49, 177.86 54.08, 78.43 -74.33, -60.5 283.52, 75.88 44.88, -65.29 out-out out 10.828 Saltbr-out 5.246 HRD-out -83.19, 107.96 -92.05, 0.22 out-in-out SNCoio in-out ActLoopNT-in 2.974 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -138.71, 159.05 APE9-dihe-na 117.28, 177.67 APE8-dihe-in -66.82, 154.33 APE8-rot-out 184.3 APE67-dihe-out -85.99, 172.12 -55.69, -41.12 APE12-dist-in 7.71 APE11-dist-in 11.043 APE10-dist-in 5.418 APE9-dist-in 4.215 None TPO172 TPO172 XRAY 3.023 0.219 0.253 C 571 404 0 0 0 0 [[16, 268]] 1.0 4cfe CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5EZVA P54646 8 551 552.0 STU:60601,C1V:60602 Type1,Allosteric Inactive DFGin 7.267 14.633 None -121.03, -63.06 -68.65, 101.9 -100.19, 25.35 279.34, 91.81 -68.17, -44.69 in-in in 9.861 Saltbr-in 2.69 HRD-in -59.46, -47.11 63.8, -4.14 in-in-in SNCiii in-in ActLoopNT-in 3.003 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.63, 144.51 APE9-dihe-na 86.66, 177.12 APE8-dihe-in -64.88, 140.75 APE8-rot-in 312.82 APE67-dihe-in -66.61, -22.38 -58.4, -32.39 APE12-dist-in 7.754 APE11-dist-in 10.437 APE10-dist-in 5.131 APE9-dist-in 4.403 None TPO172 TPO172 XRAY 2.99 0.225 0.245 A 560 424 0 0 0 0 [[16, 268]] 1.0 5ezv CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5EZVC P54646 9 551 552.0 STU:60601,C1V:60602 Type1,Allosteric Inactive DFGin 7.432 14.349 None -121.9, -67.2 -69.32, 103.91 -104.03, 30.29 280.2, 90.51 -70.5, -44.85 out-in out 10.415 Saltbr-in 3.208 HRD-in -65.9, -50.28 64.78, -4.1 in-in-out SNCiio in-out ActLoopNT-in 2.939 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.83, 151.12 APE9-dihe-na 88.46, 177.26 APE8-dihe-in -64.21, 140.09 APE8-rot-out 194.68 APE67-dihe-in -65.12, -32.21 -57.93, -31.87 APE12-dist-in 7.836 APE11-dist-in 10.536 APE10-dist-in 5.113 APE9-dist-in 4.486 None TPO172 TPO172 XRAY 2.99 0.225 0.245 C 560 426 0 0 0 0 [[16, 268]] 1.0 5ezv CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 6B1UA P54646 8 550 552.0 STU:60601,CG7:60602 Type1,Allosteric Inactive DFGin 7.269 14.441 None -129.47, -55.38 -79.75, 100.47 -94.16, 25.18 281.88, 87.91 -69.36, -38.1 out-in out 10.09 Saltbr-in 2.806 HRD-in -70.7, -48.35 62.09, 8.12 in-in-out SNCiio in-out ActLoopNT-in 3.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -119.71, 141.45 APE9-dihe-na 98.59, 173.56 APE8-dihe-in -72.38, 142.58 APE8-rot-out 181.03 APE67-dihe-in -62.9, -27.33 -58.67, -32.16 APE12-dist-in 7.972 APE11-dist-in 10.522 APE10-dist-in 4.976 APE9-dist-in 3.876 None TPO172 TPO172 XRAY 2.77 0.196 0.226 A 565 442 0 0 0 0 [[16, 268]] 1.0 6b1u CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFFC P54646 10 551 552.0 STU:61552,C1V:61553 Type1,Allosteric Inactive DFGin 6.781 14.08 None -150.62, -172.52 53.67, 68.27 -65.24, -76.3 281.99, 78.69 54.48, -69.27 out-out out 10.896 Saltbr-out 5.309 HRD-out -84.81, 105.73 -92.0, 12.06 out-in-out SNCoio in-out ActLoopNT-in 3.034 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -122.19, 170.3 APE9-dihe-na 112.32, 178.27 APE8-dihe-in -67.95, 156.54 APE8-rot-out 180.36 APE67-dihe-out -82.42, 177.62 -55.27, -42.84 APE12-dist-in 7.754 APE11-dist-in 11.137 APE10-dist-in 5.433 APE9-dist-in 3.967 None TPO172 TPO172 XRAY 3.924 0.211 0.264 C 571 423 0 0 0 0 [[16, 268]] 1.0 4cff CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CMGC CDK2 CDK2_HUMAN 4ERWA P24941 1 298 298.0 STU:301 Type1 Inactive DFGin 8.162 15.602 BLBminus -125.29, 160.66 52.47, 61.82 -60.63, 138.56 279.12, 65.63 -74.82, 135.35 out-out out 15.467 Saltbr-out 12.024 HRD-in -85.09, -48.23 77.57, -22.2 out-out-out SNCooo out-out ActLoopNT-out 9.279 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -82.87, 148.53 APE9-dihe-na -96.15, 140.05 APE8-dihe-in -88.42, 131.99 APE8-rot-out 198.97 APE67-dihe-in -59.72, -24.59 -102.21, -6.98 APE12-dist-out 19.529 APE11-dist-out 16.258 APE10-dist-out 18.687 APE9-dist-out 10.897 None None OCS177 XRAY 2.0 0.196 0.244 A 306 293 5 0 0 0 [[4, 286]] 1.0 4erw CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EZ7A P24941 1 298 298.0 STU:60301,2AN:60302,2AN:60303 Type1,Type3,Allosteric Inactive DFGin 6.978 14.625 BLBminus -145.53, 170.39 52.9, 57.73 -61.57, 149.9 287.28, 68.06 -86.96, 168.33 out-out out 16.748 Saltbr-out 14.413 HRD-in -86.07, -42.21 71.45, -15.9 out-out-out SNCooo out-out ActLoopNT-out 10.236 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -63.47, 156.15 APE9-dihe-na -125.23, 14.23 APE8-dihe-out -63.17, -28.79 APE8-rot-in 293.42 APE67-dihe-in -53.71, -31.99 -57.23, -35.61 APE12-dist-out 18.472 APE11-dist-out 18.425 APE10-dist-out 13.977 APE9-dist-out 11.306 None None None XRAY 2.49 0.22 0.274 A 306 298 0 0 0 0 [[4, 286]] 1.0 4ez7 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1AQ1A P24941 1 298 298.0 STU:299 Type1 Inactive DFGin 7.283 14.934 BLBplus -138.32, 166.15 50.99, 60.93 -140.99, 149.68 67.4, 106.52 86.86, 1.1 out-out out 14.888 Saltbr-out 13.171 HRD-in -84.88, -53.74 82.51, -14.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -59.57, 119.45 APE9-dihe-na -86.87, 141.05 APE8-dihe-in -59.86, 138.54 APE8-rot-out 207.57 APE67-dihe-in -54.1, -30.89 -108.21, -4.5 APE12-dist-none 999.0 APE11-dist-out 16.32 APE10-dist-out 19.124 APE9-dist-out 10.677 None None None XRAY 2.0 0.22 0.26 A 298 277 21 0 0 13 [[4, 286]] 1.0 1aq1 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7NVQA P24941 1 294 298.0 STU:301 Type1 Inactive DFGin 7.026 14.701 BLBplus -138.98, 166.91 60.92, 69.03 -161.06, 162.59 72.07, 108.19 128.48, -14.92 out-out out 14.351 Saltbr-out 15.166 HRD-in -80.38, -55.15 83.91, -13.55 out-out-out SNCooo out-out ActLoopNT-out 6.029 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.14, 127.57 APE9-dihe-na -77.4, 113.59 APE8-dihe-in -55.3, 141.9 APE8-rot-out 195.1 APE67-dihe-in -55.26, -27.26 -100.43, -4.92 APE12-dist-out 18.864 APE11-dist-out 17.703 APE10-dist-out 18.976 APE9-dist-out 9.89 None None None XRAY 2.05 0.24 0.288 A 300 287 7 0 0 0 [[4, 286]] 1.0 7nvq CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC GSK3B GSK3B_HUMAN 1Q3DA P49841 35 385 420.0 STU:451 Type1 Active DFGin 7.206 14.411 BLAminus -139.48, 178.33 63.94, 87.17 -99.43, 23.77 282.58, 69.4 -66.25, -14.58 in-in in 8.701 Saltbr-in 2.855 HRD-in -65.74, -44.7 66.01, 11.52 in-in-in SNCiii in-in ActLoopNT-in 3.036 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -94.53, 169.72 APE9-dihe-na 81.56, 143.56 APE8-dihe-in -91.54, 154.32 APE8-rot-in 294.67 APE67-dihe-inflip 96.36, -28.56 -51.12, 132.48 APE12-dist-in 13.074 APE11-dist-in 11.108 APE10-dist-in 6.087 APE9-dist-in 3.274 None None None XRAY 2.2 0.23 0.252 A 424 339 12 0 0 0 [[56, 340]] 1.0 1q3d CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1Q3DB P49841 35 383 420.0 STU:452 Type1 Active DFGin 7.26 14.419 BLAminus -137.95, 177.39 64.41, 87.07 -97.99, 22.53 282.7, 70.11 -63.96, -17.29 in-in in 8.708 Saltbr-in 2.972 HRD-in -67.72, -45.35 66.86, 12.1 in-in-in SNCiii in-in ActLoopNT-in 3.024 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -93.75, 170.28 APE9-dihe-na 79.08, 144.81 APE8-dihe-in -89.94, 151.95 APE8-rot-in 299.26 APE67-dihe-inflip 101.61, -31.22 -54.51, 132.99 APE12-dist-in 13.085 APE11-dist-in 11.088 APE10-dist-in 6.146 APE9-dist-in 3.238 None None None XRAY 2.2 0.23 0.252 B 424 339 10 0 0 0 [[56, 340]] 1.0 1q3d CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
OTHER ERN1 ERN1_HUMAN 4YZCA O75460 562 963 977.0 STU:1001 Type1 None DFGin 4.54 13.598 BLAminus -149.66, -173.45 57.49, 66.53 -77.65, -2.16 287.89, 65.87 -48.01, -38.7 in-none in 9.363 Saltbr-none 999.0 HRD-in -69.99, -44.37 70.23, -12.54 none-in-in SNCnii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -68.95, 160.8 APE9-dihe-na 106.7, 168.85 APE8-dihe-in -105.56, 142.33 APE8-rot-in 309.63 APE67-dihe-inflip 90.78, -21.58 -55.3, 131.97 APE12-dist-in 10.401 APE11-dist-in 11.328 APE10-dist-in 5.406 APE9-dist-in 3.601 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.494 0.249 0.289 A 405 385 17 0 0 1 [[571, 832]] 1.0 4yzc OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZCB O75460 562 963 977.0 STU:1001 Type1 None DFGin 4.362 13.613 BLAminus -140.88, -173.22 59.3, 72.64 -84.99, 5.45 286.37, 62.28 -53.44, -38.69 in-none in 9.608 Saltbr-none 999.0 HRD-in -70.83, -44.64 74.46, -16.49 none-in-in SNCnii in-in ActLoopNT-in 2.971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -78.48, 164.52 APE9-dihe-na 106.87, 177.31 APE8-dihe-in -111.04, 139.81 APE8-rot-in 310.36 APE67-dihe-inflip 90.66, -20.76 -52.98, 131.15 APE12-dist-in 10.836 APE11-dist-in 11.233 APE10-dist-in 5.394 APE9-dist-in 3.693 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.494 0.249 0.289 B 405 384 18 0 0 2 [[571, 832]] 1.0 4yzc OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER STK16 STK16_HUMAN 2BUJA O75716 13 299 305.0 STU:61301,STU:61302 Type1,Allosteric Active DFGin 5.288 13.003 BLAminus -135.89, -178.46 61.93, 77.23 -105.11, 26.12 316.44, 178.21 -83.9, 1.31 in-in in 9.024 Saltbr-in 2.989 HRD-in -74.11, -51.49 80.14, -8.2 in-in-in SNCiii in-in ActLoopNT-in 2.971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.51, -7.91 APE9-dihe-na -119.57, 103.56 APE8-dihe-in -42.23, 126.34 APE8-rot-in 303.64 APE67-dihe-in -75.83, -5.68 -58.31, -41.55 APE12-dist-in 12.919 APE11-dist-in 9.177 APE10-dist-in 4.941 APE9-dist-in 4.0 R19H,R266W None None XRAY 2.6 0.187 0.229 A 317 283 4 0 0 0 [[20, 292]] 1.0 2buj OTHER_STK16_HUMAN OTHER 4.7e-40 143.7 1 258 258 165 166 167 169 171 49 65 69 145 147 146 148 217 202 197 196 195 194 193 192 191 99 Serine/threonine-protein kinase 16
OTHER STK16 STK16_HUMAN 2BUJB O75716 13 297 305.0 STU:61299,STU:61300 Type1,Type1 Active DFGin 5.474 13.493 BLAminus -129.22, -175.67 64.04, 67.15 -107.31, -12.83 320.05, 164.52 -59.54, -39.15 in-in in 8.947 Saltbr-in 2.374 HRD-in -61.68, -60.28 75.79, -4.77 in-in-in SNCiii in-in ActLoopNT-in 3.197 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.51, -36.93 APE9-dihe-na -101.29, 104.25 APE8-dihe-in -41.65, 126.41 APE8-rot-in 314.22 APE67-dihe-in -74.19, -9.63 -59.55, -34.23 APE12-dist-in 13.948 APE11-dist-in 10.185 APE10-dist-in 6.538 APE9-dist-in 3.697 R19H,R266W None None XRAY 2.6 0.187 0.229 B 317 277 8 0 0 0 [[20, 292]] 1.0 2buj OTHER_STK16_HUMAN OTHER 4.7e-40 143.7 1 258 258 165 166 167 169 171 49 65 69 145 147 146 148 217 202 197 196 195 194 193 192 191 99 Serine/threonine-protein kinase 16
OTHER TTK TTK_HUMAN 3HMOA P33981 514 794 857.0 STU:1 Type1 Inactive DFGin 4.034 15.278 ABAminus -96.9, -14.35 -154.28, 164.59 -116.14, 11.51 302.21, 156.99 70.91, 11.96 out-out out 11.148 Saltbr-out 6.638 HRD-in -61.3, -53.03 75.35, 1.42 out-out-out SNCooo out-out ActLoopNT-out 11.68 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -169.39 APE9-dihe-na 94.05, 108.89 APE8-dihe-in -96.62, 156.5 APE8-rot-out 54.19 APE67-dihe-in -64.02, -25.79 -101.71, 14.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.123 APE9-dist-out 11.563 None None None XRAY 2.4 0.217 0.261 A 342 257 24 0 0 12 [[525, 791]] 1.0 3hmo OTHER_TTK_HUMAN CAMK 1.1e-53 188.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
STE MAP2K6 MP2K6_HUMAN 3FMEA P52564 47 333 334.0 STU:60001 Type1 Inactive None 999.0 999.0 None -108.01, 128.57 -82.08, 37.27 -74.9, 999.0 999.0, 999.0 999.0, 999.0 na-na na 16.092 Saltbr-na 15.231 HRD-in -57.54, -47.19 80.18, -0.06 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_nnno APE10-dihe-na 999.0, 108.95 APE9-dihe-na -76.08, 66.3 APE8-dihe-in -91.33, 156.42 APE8-rot-na 298.81 APE67-dihe-out -82.0, 103.94 -93.42, 147.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.976 S207D,T211D None None XRAY 2.26 0.213 0.236 A 290 267 20 0 0 15 [[53, 314]] 1.0 3fme STE_MAP2K6_HUMAN STE 3.8e-85 291.3 3 257 255 196 197 198 200 202 82 99 103 176 178 177 179 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
STE MAP3K5 M3K5_HUMAN 4BF2A Q99683 671 939 1374.0 STU:1940 Type1 Inactive DFGin 7.213 13.807 BLAminus -114.3, -178.78 51.44, 86.67 -90.54, 15.85 294.66, 96.8 -75.78, -2.2 out-none out 10.049 Saltbr-none 999.0 HRD-in -67.79, -49.78 78.33, -4.9 none-in-out SNCnio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -128.2, 134.23 APE9-dihe-na -68.74, -169.24 APE8-dihe-in -70.38, 133.03 APE8-rot-in 304.95 APE67-dihe-in -66.2, -12.84 -50.6, -52.99 APE12-dist-in 11.059 APE11-dist-out 5.44 APE10-dist-out 9.736 APE9-dist-in 3.512 T838E None None XRAY 2.11 0.208 0.247 A 334 253 16 0 0 6 [[678, 938]] 1.0 4bf2 STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 4BF2B Q99683 671 940 1374.0 STU:1941 Type1 Inactive DFGin 6.92 13.803 BLAminus -128.63, -177.63 56.0, 77.77 -86.85, 11.45 292.4, 104.75 -69.02, -19.49 in-none in 9.74 Saltbr-none 999.0 HRD-in -67.52, -45.29 72.76, -9.25 none-in-out SNCnio in-out ActLoopNT-in 3.012 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 145.57 APE9-dihe-na -77.44, -148.98 APE8-dihe-in -83.86, 130.43 APE8-rot-in 307.99 APE67-dihe-in -59.87, -30.7 -43.72, -58.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.696 APE9-dist-in 3.527 T838E None None XRAY 2.11 0.208 0.247 B 334 252 18 0 0 9 [[678, 938]] 1.0 4bf2 STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 2CLQA Q99683 670 940 1374.0 STU:1941 Type1 Inactive DFGinter 5.918 8.469 BABtrans -91.39, 129.8 -141.56, 7.65 -79.81, 110.16 226.87, 94.37 134.88, -46.11 out-out out 10.127 Saltbr-out 4.796 HRD-in -81.27, -49.85 78.55, 0.8 out-in-out SNCoio in-out ActLoopNT-in 3.025 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -136.64, 134.41 APE9-dihe-na -79.2, -159.26 APE8-dihe-in -79.76, 137.19 APE8-rot-in 323.06 APE67-dihe-in -73.67, -16.9 -62.96, -40.27 APE12-dist-in 11.61 APE11-dist-out 6.223 APE10-dist-out 10.04 APE9-dist-in 3.702 None None None XRAY 2.3 0.204 0.257 A 295 263 8 0 0 5 [[678, 938]] 1.0 2clq STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 2CLQB Q99683 670 940 1374.0 STU:1941 Type1 Inactive DFGinter 6.564 8.021 BABtrans -97.55, 126.7 -140.68, 10.18 -79.54, 109.54 215.05, 109.45 130.73, -46.4 in-none in 9.98 Saltbr-none 999.0 HRD-in -83.48, -49.36 79.39, -1.77 none-in-out SNCnio in-out ActLoopNT-in 3.001 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -136.24, 136.94 APE9-dihe-na -82.54, -165.1 APE8-dihe-in -71.26, 138.19 APE8-rot-in 313.5 APE67-dihe-in -70.89, -23.23 -61.89, -43.74 APE12-dist-none 999.0 APE11-dist-out 6.267 APE10-dist-out 10.013 APE9-dist-in 3.749 None None None XRAY 2.3 0.204 0.257 B 295 259 12 0 0 8 [[678, 938]] 1.0 2clq STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE PAK4 PAK4_HUMAN 5VEDA O96013 300 589 591.0 STU:601 Type1 Inactive DFGin 7.591 14.871 BLAminus -137.67, -169.84 57.61, 74.14 -100.29, 38.24 286.21, 78.54 -72.3, -31.74 in-out in 8.771 Saltbr-out 5.279 HRD-in -70.67, -47.26 60.82, 22.3 out-in-in SNCoii in-in ActLoopNT-in 2.978 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.74, 169.93 APE9-dihe-na 110.0, -167.24 APE8-dihe-in -107.4, 122.99 APE8-rot-in 313.49 APE67-dihe-in -72.02, -18.93 -37.81, -47.81 APE12-dist-in 8.493 APE11-dist-in 11.13 APE10-dist-in 5.271 APE9-dist-in 3.412 None SEP474 SEP474 XRAY 2.301 0.231 0.277 A 319 290 0 0 0 0 [[321, 572]] 1.0 5ved STE_PAK4_HUMAN STE 2.4e-88 301.8 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE STK24 STK24_HUMAN 3CKXA Q9Y6E0 32 310 443.0 STU:60305 Type1 Inactive DFGin 6.554 14.149 BLAminus -132.73, 176.63 58.71, 84.09 -98.54, 27.24 290.72, 79.22 -58.51, -31.96 in-out in 8.018 Saltbr-out 4.137 HRD-in -69.03, -39.23 63.51, 16.34 out-in-in SNCoii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.66, 153.77 APE9-dihe-na 128.68, -169.17 APE8-dihe-in -106.02, 124.24 APE8-rot-in 327.58 APE67-dihe-in -59.9, -29.27 -40.36, -54.25 APE12-dist-in 8.432 APE11-dist-in 11.065 APE10-dist-in 5.473 APE9-dist-in 3.366 None TPO190 TPO190 XRAY 2.7 0.204 0.268 A 304 277 2 0 0 0 [[36, 286]] 1.0 3ckx STE_STK24_HUMAN STE 3.6e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QMYA Q9Y6E0 20 310 443.0 STU:60401 Type1 Active DFGin 6.746 14.586 BLAminus -133.42, 171.19 64.86, 84.46 -97.43, 25.83 286.76, 75.76 -58.45, -26.25 in-in in 8.74 Saltbr-in 3.092 HRD-in -71.07, -50.71 71.45, 2.06 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.42, 163.67 APE9-dihe-na 122.07, -169.11 APE8-dihe-in -113.85, 118.11 APE8-rot-in 305.93 APE67-dihe-in -57.67, -29.25 -41.23, -48.77 APE12-dist-in 8.319 APE11-dist-in 10.932 APE10-dist-in 5.108 APE9-dist-in 3.246 None TPO190 TPO190 XRAY 1.883 0.18 0.22 A 310 288 0 0 0 0 [[36, 286]] 1.0 4qmy STE_STK24_HUMAN STE 3.9e-100 340.4 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
TKL IRAK4 IRAK4_HUMAN 2OICA Q9NWZ3 163 458 460.0 STU:1 Type1 Active DFGin 7.542 14.55 BLAminus -120.17, -157.79 43.1, 78.64 -95.77, 16.12 291.84, 81.73 -52.42, -46.68 in-in in 9.164 Saltbr-in 2.745 HRD-in -70.7, -51.8 81.1, -5.15 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.11, 162.72 APE9-dihe-na 127.09, -176.82 APE8-dihe-in -109.75, 123.25 APE8-rot-in 303.17 APE67-dihe-in -63.31, -16.61 -48.06, -48.45 APE12-dist-in 10.133 APE11-dist-in 11.724 APE10-dist-in 6.347 APE9-dist-in 3.446 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 A 301 279 17 0 0 6 [[183, 456]] 1.0 2oic TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICB Q9NWZ3 164 459 460.0 STU:2 Type1 Active DFGin 7.301 14.318 BLAminus -135.72, -165.01 43.24, 86.39 -100.56, 27.64 301.91, 89.45 -68.65, -40.8 in-in in 8.997 Saltbr-in 3.022 HRD-in -70.79, -51.12 80.52, -12.66 in-in-in SNCiii in-in ActLoopNT-in 2.849 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.84, 167.54 APE9-dihe-na 125.4, -168.64 APE8-dihe-in -121.45, 120.26 APE8-rot-in 302.84 APE67-dihe-in -66.81, -13.26 -49.44, -48.37 APE12-dist-in 10.093 APE11-dist-in 11.718 APE10-dist-in 6.031 APE9-dist-in 3.687 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 B 301 278 18 0 0 6 [[183, 456]] 1.0 2oic TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICC Q9NWZ3 161 458 460.0 STU:3 Type1 None DFGin 7.642 14.512 BLAminus -134.38, -175.33 55.45, 88.83 -103.9, 2.57 299.42, 100.27 -42.77, 999.0 in-in in 9.176 Saltbr-in 3.297 HRD-in -70.98, -49.49 84.28, -16.44 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -109.35, 145.04 APE9-dihe-na 142.04, -179.34 APE8-dihe-in -123.52, 118.39 APE8-rot-in 307.07 APE67-dihe-in -69.67, -21.31 -65.38, -24.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.567 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 C 301 280 18 0 0 10 [[183, 456]] 1.0 2oic TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICD Q9NWZ3 161 459 460.0 STU:4 Type1 Active DFGin 6.964 14.795 BLAminus -128.12, -176.74 47.11, 78.66 -89.74, 11.31 298.87, 93.52 -54.67, -36.62 in-in in 8.701 Saltbr-in 2.614 HRD-in -65.25, -53.17 80.56, 0.44 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.06, 151.9 APE9-dihe-na 143.33, 177.59 APE8-dihe-in -104.02, 127.84 APE8-rot-in 302.2 APE67-dihe-in -61.5, -18.42 -54.54, -50.36 APE12-dist-in 10.572 APE11-dist-in 11.674 APE10-dist-in 6.11 APE9-dist-in 3.484 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 D 301 287 12 0 0 2 [[183, 456]] 1.0 2oic TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRYC Q9NWZ3 164 458 460.0 STU:503 Type1 Active DFGin 7.396 13.991 BLAminus -129.87, 177.33 66.53, 79.75 -106.36, 3.08 302.75, 99.86 -41.96, -44.4 in-in in 9.05 Saltbr-in 2.876 HRD-in -69.99, -46.9 74.7, -3.92 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.06, 166.37 APE9-dihe-na 122.8, -162.09 APE8-dihe-in -122.72, 120.05 APE8-rot-in 297.38 APE67-dihe-in -61.23, -20.14 -50.62, -47.6 APE12-dist-in 11.845 APE11-dist-in 12.224 APE10-dist-in 7.0 APE9-dist-in 3.864 None TPO345 TPO345 XRAY 2.15 0.212 0.261 C 307 281 14 0 0 4 [[183, 456]] 1.0 2nry TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRYD Q9NWZ3 164 460 460.0 STU:501 Type1 Active DFGin 7.103 14.601 BLAminus -126.69, 167.35 70.82, 64.69 -93.05, 43.05 345.42, 126.85 -89.85, -18.2 in-in in 9.176 Saltbr-in 2.95 HRD-in -59.6, -55.9 83.92, -5.49 in-in-in SNCiii in-in ActLoopNT-in 2.724 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.15, 176.95 APE9-dihe-na 112.24, -167.34 APE8-dihe-in -128.61, 119.15 APE8-rot-in 302.8 APE67-dihe-in -66.3, -17.75 -48.9, -47.71 APE12-dist-in 10.025 APE11-dist-in 11.615 APE10-dist-in 6.271 APE9-dist-in 3.538 None TPO345 TPO345 XRAY 2.15 0.212 0.261 D 307 283 14 0 0 5 [[183, 456]] 1.0 2nry TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U97A Q9NWZ3 166 458 460.0 STU:501 Type1 None DFGin 7.218 14.495 BLAminus -133.4, -177.52 44.45, 65.76 -75.86, 30.58 295.34, 78.33 -61.24, -17.68 in-in in 9.111 Saltbr-in 2.796 HRD-in -81.28, -51.43 74.22, 0.69 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.32, 150.98 APE9-dihe-na 154.49, -177.45 APE8-dihe-in -96.07, 115.4 APE8-rot-in 303.66 APE67-dihe-in -67.54, -17.85 -61.65, -28.02 APE12-dist-in 9.909 APE11-dist-in 11.839 APE10-dist-in 7.032 APE9-dist-in 3.824 D311N None None XRAY 2.65 0.206 0.251 A 312 272 21 0 0 8 [[183, 456]] 1.0 4u97 TKL_IRAK4_HUMAN TKL 3e-83 285.4 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U9AA Q9NWZ3 166 458 460.0 STU:501 Type1 None DFGin 7.045 14.907 BLAminus -101.08, -157.39 29.3, 88.18 -95.05, 25.51 282.71, 82.79 -64.14, 4.87 in-in in 8.998 Saltbr-in 3.226 HRD-in -68.43, -44.05 62.5, 13.64 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.36, 146.03 APE9-dihe-na 162.68, -156.1 APE8-dihe-in -121.4, 112.37 APE8-rot-in 316.45 APE67-dihe-in -59.48, -18.83 -58.3, -38.15 APE12-dist-in 9.983 APE11-dist-in 11.951 APE10-dist-in 7.219 APE9-dist-in 3.878 D311N None None XRAY 2.8 0.185 0.24 A 312 272 21 0 0 8 [[183, 456]] 1.0 4u9a TKL_IRAK4_HUMAN TKL 3e-83 285.4 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRYA Q9NWZ3 164 458 460.0 STU:504 Type1 Inactive DFGin 7.039 13.85 BLBminus -119.68, 177.11 59.06, 71.69 -112.23, -126.05 350.98, 70.79 78.1, -70.69 in-in in 9.03 Saltbr-in 2.758 HRD-in -65.27, -50.09 77.33, -7.45 in-in-in SNCiii in-in ActLoopNT-in 2.754 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.61, 161.22 APE9-dihe-na 128.42, -175.43 APE8-dihe-in -120.1, 117.97 APE8-rot-in 299.02 APE67-dihe-in -57.48, -21.15 -43.86, -55.05 APE12-dist-in 10.988 APE11-dist-in 13.053 APE10-dist-in 7.67 APE9-dist-in 3.682 None TPO345 TPO345 XRAY 2.15 0.212 0.261 A 307 287 8 0 0 5 [[183, 456]] 1.0 2nry TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRYB Q9NWZ3 164 458 460.0 STU:502 Type1 Inactive DFGin 7.33 14.211 BLBminus -121.91, 179.32 63.59, 83.43 -104.91, -160.11 313.36, 100.13 93.41, -69.05 in-out in 8.992 Saltbr-out 3.775 HRD-in -74.38, -53.26 85.42, -10.52 out-in-in SNCoii in-in ActLoopNT-in 2.61 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.77, 162.03 APE9-dihe-na 124.37, -168.49 APE8-dihe-in -121.78, 111.1 APE8-rot-in 307.1 APE67-dihe-in -48.86, -28.56 -36.36, -56.5 APE12-dist-in 9.932 APE11-dist-in 12.138 APE10-dist-in 6.485 APE9-dist-in 3.62 None TPO345 TPO345 XRAY 2.15 0.212 0.261 B 307 287 8 0 0 5 [[183, 456]] 1.0 2nry TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U97B Q9NWZ3 166 458 460.0 STU:501 Type1 Inactive DFGin 5.294 14.217 None -136.34, -175.59 46.99, 62.58 -120.73, 999.0 61.34, 86.78 999.0, 999.0 in-in in 9.393 Saltbr-in 2.996 HRD-in -71.9, -50.3 83.45, -13.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -128.91, -19.36 APE9-dihe-na -55.91, 145.79 APE8-dihe-in -64.15, 91.3 APE8-rot-in 291.9 APE67-dihe-in -57.49, -34.64 -51.29, -30.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.145 D311N None None XRAY 2.65 0.206 0.251 B 312 270 23 0 0 12 [[183, 456]] 1.0 4u97 TKL_IRAK4_HUMAN TKL 3e-83 285.4 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U9AB Q9NWZ3 166 458 460.0 STU:501 Type1 Inactive DFGin 5.633 14.406 None -136.0, 173.79 77.97, 80.6 -165.88, 999.0 67.94, 103.04 999.0, 999.0 in-in in 9.402 Saltbr-in 2.924 HRD-in -69.54, -47.75 75.57, 5.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -138.84, -18.64 APE9-dihe-na -63.49, 153.65 APE8-dihe-in -64.27, 92.38 APE8-rot-in 304.32 APE67-dihe-in -63.41, -26.11 -54.68, -17.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.359 D311N None None XRAY 2.8 0.185 0.24 B 312 270 23 0 0 12 [[183, 456]] 1.0 4u9a TKL_IRAK4_HUMAN TKL 3e-83 285.4 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL LIMK1 LIMK1_HUMAN 3S95A P53667 330 637 647.0 STU:60001 Type1 Active DFGin 6.504 14.072 BLAminus -132.12, 176.01 61.94, 79.29 -96.74, 17.56 299.36, 104.43 -67.12, -24.68 in-in in 7.478 Saltbr-in 2.77 HRD-in -69.3, -54.34 71.96, -1.22 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -137.33, 152.92 APE9-dihe-na 118.99, 175.51 APE8-dihe-in -76.56, 127.6 APE8-rot-na 188.61 APE67-dihe-in -66.82, -23.07 -64.42, -23.72 APE12-dist-in 9.219 APE11-dist-in 11.444 APE10-dist-in 5.645 APE9-dist-in 3.746 None None None XRAY 1.65 0.157 0.181 A 310 288 20 0 0 20 [[339, 606]] 1.0 3s95 TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3 266 264 477 478 479 481 483 368 384 388 457 459 458 460 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 3S95B P53667 330 637 647.0 STU:60001 Type1 Active DFGin 6.465 13.723 BLAminus -137.18, 172.16 66.04, 80.35 -97.8, 13.37 302.38, 103.91 -61.7, -26.69 in-in in 7.806 Saltbr-in 2.596 HRD-in -67.95, -51.91 71.9, -3.03 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -131.01, 146.52 APE9-dihe-na 126.16, 169.25 APE8-dihe-in -67.25, 124.73 APE8-rot-na 183.11 APE67-dihe-in -72.71, -16.93 -64.76, -21.17 APE12-dist-in 9.115 APE11-dist-in 11.268 APE10-dist-in 5.405 APE9-dist-in 3.783 None None None XRAY 1.65 0.157 0.181 B 310 288 20 0 0 20 [[339, 606]] 1.0 3s95 TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3 266 264 477 478 479 481 483 368 384 388 457 459 458 460 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL RIPK2 RIPK2_HUMAN 5NG2A O43353 5 298 540.0 STU:401 Type1 Inactive DFGin 5.959 13.876 BLAminus -127.83, 178.19 61.49, 80.49 -96.67, 24.09 288.33, 78.8 -62.82, -31.8 in-in in 8.091 Saltbr-in 2.902 HRD-in -73.87, -50.37 57.71, 19.44 in-in-out SNCiio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 149.89 APE8-dihe-in -77.86, 146.25 APE8-rot-out 189.94 APE67-dihe-in -66.59, -20.81 -105.1, 1.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.855 D146N None None XRAY 2.8 0.209 0.226 A 304 274 20 0 0 14 [[18, 292]] 1.0 5ng2 TKL_RIPK2_HUMAN TKL 2.6e-72 249.5 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5NG2B O43353 5 298 540.0 STU:401 Type1 Inactive DFGin 5.987 13.9 BLAminus -127.96, 178.42 61.45, 80.21 -96.5, 23.45 288.92, 78.23 -62.02, -31.71 in-in in 8.093 Saltbr-in 2.894 HRD-in -73.84, -50.5 58.4, 18.77 in-in-out SNCiio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.58 APE8-dihe-in -77.44, 145.88 APE8-rot-out 189.53 APE67-dihe-in -67.7, -20.58 -104.84, 1.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.79 D146N None None XRAY 2.8 0.209 0.226 B 304 278 16 0 0 15 [[18, 292]] 1.0 5ng2 TKL_RIPK2_HUMAN TKL 2.6e-72 249.5 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL TGFBR1 TGFR1_HUMAN 5E8XA P36897 200 503 503.0 STU:601 Type1 Active DFGin 7.401 13.771 BLAminus -132.02, 177.79 68.95, 84.86 -101.89, 20.89 298.69, 99.78 -60.9, -22.78 in-in in 7.646 Saltbr-in 3.316 HRD-in -78.83, -50.32 78.23, -2.28 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.2, 171.93 APE9-dihe-na 104.3, 177.57 APE8-dihe-in -80.96, 119.4 APE8-rot-in 304.53 APE67-dihe-in -55.33, -34.35 -53.44, -41.29 APE12-dist-in 11.709 APE11-dist-in 11.927 APE10-dist-in 6.258 APE9-dist-in 3.946 T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F None None XRAY 1.45 0.191 0.21 A 307 304 0 0 0 0 [[205, 494]] 1.0 5e8x TKL_TGFBR1_HUMAN TKL 2.3e-85 292.2 3 266 264 350 351 352 354 356 232 245 249 330 332 331 333 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 5E8WA P36897 200 501 503.0 STU:60601 Type1 Active DFGin 6.216 12.991 BLAminus -115.91, -168.56 48.03, 66.8 -87.81, 6.99 303.66, 6.47 -53.89, -34.67 in-in in 7.561 Saltbr-in 2.815 HRD-in -71.33, -51.46 73.08, -1.55 in-in-in SNCiii in-in ActLoopNT-in 2.992 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -81.36, -32.83 APE9-dihe-na -81.66, -157.24 APE8-dihe-in -82.54, 122.58 APE8-rot-in 299.35 APE67-dihe-in -53.78, -37.25 -53.32, -45.52 APE12-dist-in 13.054 APE11-dist-in 12.418 APE10-dist-in 6.3 APE9-dist-in 3.738 T204D None None XRAY 1.86 0.168 0.186 A 307 302 0 0 0 0 [[205, 494]] 1.0 5e8w TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3 266 264 350 351 352 354 356 232 245 249 330 332 331 333 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR2 TGFR2_HUMAN 5E8YA P37173 240 541 567.0 STU:601 Type1 Inactive DFGin 7.431 13.638 ABAminus -147.57, -29.88 -97.01, 88.29 -98.27, 19.66 300.85, 114.87 -63.28, -27.98 in-in in 7.663 Saltbr-in 2.684 HRD-in -60.19, -53.17 75.99, -7.12 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.67, 141.68 APE9-dihe-na 119.62, -164.78 APE8-dihe-in -99.54, 120.03 APE8-rot-in 310.13 APE67-dihe-in -59.04, -35.21 -51.44, -37.92 APE12-dist-in 11.211 APE11-dist-in 12.073 APE10-dist-in 5.974 APE9-dist-in 4.011 E431A,R433A,E485A,K488A,R493A,R495A None None XRAY 2.05 0.198 0.227 A 316 298 4 0 0 0 [[244, 540]] 1.0 5e8y TKL_TGFBR2_HUMAN TKL 1.9e-77 266.3 2 266 265 396 397 398 400 402 277 290 294 376 378 377 379 446 428 423 422 421 420 419 418 417 326 TGF-beta receptor type-2
TYR ALK ALK_HUMAN 3LCSA Q9UM73 1096 1399 1620.0 STU:1 Type1 Inactive DFGin 6.33 14.912 ABAminus -115.64, -37.74 -102.74, 114.2 -112.42, 20.01 289.12, 86.66 -56.01, -38.26 in-in in 7.78 Saltbr-in 2.662 HRD-in -69.52, -44.32 78.89, -12.54 in-out-out SNCioo out-out ActLoopNT-out 6.794 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.07, -13.05 APE9-dihe-in -64.04, 139.47 APE8-dihe-in -80.51, 60.39 APE8-rot-na 31.54 APE67-dihe-in -67.01, -14.6 -60.37, -27.86 APE12-dist-na 15.308 APE11-dist-na 15.569 APE10-dist-na 10.539 APE9-dist-out 8.296 S1281G None None XRAY 1.95 0.196 0.229 A 344 304 0 0 0 0 [[1116, 1385]] 1.0 3lcs TYR_ALK_HUMAN TYR 5e-90 307.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR CSK CSK_HUMAN 3D7TA P41240 188 450 450.0 STU:6335 Type1 Inactive DFGin 4.848 13.727 None -129.86, -75.48 -112.49, 120.17 -68.38, 132.53 310.55, 71.3 -108.94, 999.0 in-in in 9.709 Saltbr-in 3.505 HRD-in -84.81, -41.33 76.65, -6.36 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 92.32 APE8-rot-na 27.67 APE67-dihe-in -57.33, -30.65 -43.31, -55.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K361A,K362A None None XRAY 2.899 0.239 0.278 A 269 249 14 0 0 14 [[195, 442]] 1.0 3d7t TYR_CSK_HUMAN TYR 5.7e-87 297.2 1 260 260 331 332 333 335 337 222 236 240 311 313 312 314 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
TYR CSK CSK_HUMAN 1BYGA P41240 187 448 450.0 STU:501 Type1 Inactive DFGinter 10.86 7.923 BABtrans -99.17, 153.06 -105.84, -7.01 -68.56, 146.18 156.4, 90.07 -161.79, 133.09 out-out out 14.775 Saltbr-out 12.646 HRD-in -79.54, -44.6 72.05, -5.51 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.52 APE8-dihe-in -71.25, 96.92 APE8-rot-na 16.81 APE67-dihe-in -75.84, -8.12 -42.46, -43.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.292 None None None XRAY 2.4 0.199 0.287 A 278 246 16 0 0 12 [[195, 442]] 1.0 1byg TYR_CSK_HUMAN TYR 1.2e-87 299.5 1 260 260 331 332 333 335 337 222 236 240 311 313 312 314 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
TYR EPHB4 EPHB4_HUMAN 3ZEWA P54760 609 888 987.0 STU:1889 Type1 None DFGin 6.122 14.359 BLAminus -139.16, 174.72 57.83, 79.91 -97.95, 22.7 299.52, 94.02 -63.4, -45.19 in-in in 8.066 Saltbr-in 2.796 HRD-in -71.2, -51.67 69.26, -8.65 in-in-none SNCiin in-none ActLoopNT-in 2.821 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 56.2 APE9-dihe-in -113.28, 124.67 APE8-dihe-in -75.39, 88.73 APE8-rot-na 23.8 APE67-dihe-in -74.18, -2.68 -39.84, -58.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.292 APE9-dist-in 6.071 None PTR774 PTR774 XRAY 2.5 0.24 0.282 A 298 270 10 0 0 6 [[615, 876]] 1.0 3zew TYR_EPHB4_HUMAN TYR 2.6e-104 354.1 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 3ZEWB P54760 609 887 987.0 STU:1888 Type1 None DFGin 6.6 14.69 BLAminus -136.46, 179.33 65.25, 57.03 -88.32, 123.85 306.76, 101.31 132.26, 999.0 in-none in 7.638 Saltbr-none 999.0 HRD-in -68.01, -45.09 76.33, -22.89 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.88 APE8-dihe-in -93.06, 95.29 APE8-rot-na 27.85 APE67-dihe-in -68.25, -2.97 -47.06, -56.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.554 None PTR774 PTR774 XRAY 2.5 0.24 0.282 B 298 252 27 0 0 21 [[615, 876]] 1.0 3zew TYR_EPHB4_HUMAN TYR 2.6e-104 354.1 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2YN8A P54760 608 888 987.0 STU:1889 Type1 Inactive DFGin 6.427 14.617 None -130.9, 178.33 70.32, 85.06 -121.95, 999.0 309.1, 102.44 999.0, 999.0 in-in in 7.533 Saltbr-in 2.751 HRD-in -74.77, -43.96 71.71, -21.91 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.38 APE8-rot-na 24.51 APE67-dihe-in -59.12, -26.62 -41.36, -49.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y774E,A803V,V870I None None XRAY 2.11 0.197 0.234 A 298 253 28 0 0 23 [[615, 876]] 1.0 2yn8 TYR_EPHB4_HUMAN TYR 4.3e-105 356.6 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2YN8B P54760 606 888 987.0 STU:1889 Type1 Inactive DFGin 6.429 14.627 None -131.1, 178.0 70.17, 85.21 -120.37, 999.0 309.66, 103.01 999.0, 999.0 in-in in 7.486 Saltbr-in 2.76 HRD-in -75.37, -48.88 76.16, -20.77 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.61 APE8-rot-na 24.46 APE67-dihe-in -59.58, -26.36 -40.69, -50.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y774E,A803V,V870I None None XRAY 2.11 0.197 0.234 B 298 260 23 0 0 23 [[615, 876]] 1.0 2yn8 TYR_EPHB4_HUMAN TYR 4.3e-105 356.6 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR FES FES_HUMAN 3BKBA P07332 449 821 822.0 STU:826 Type1 Inactive DFGin 6.866 14.424 BLAminus -130.98, -162.57 38.75, 71.71 -85.89, 14.89 281.41, 76.5 -59.73, -36.44 in-in in 6.772 Saltbr-in 2.62 HRD-in -78.26, -50.49 76.66, -9.4 in-in-out SNCiio in-out ActLoopNT-in 2.82 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 47.37, 40.72 APE9-dihe-in -62.75, 132.26 APE8-dihe-in -76.49, 72.71 APE8-rot-na 30.4 APE67-dihe-in -70.68, -13.35 -50.64, -47.62 APE12-dist-na 8.341 APE11-dist-na 11.981 APE10-dist-na 11.225 APE9-dist-in 7.354 None None None XRAY 1.78 0.15 0.189 A 377 373 0 0 0 0 [[561, 816]] 1.0 3bkb TYR_FES_HUMAN TYR 6.6e-94 320.0 1 260 260 700 701 702 704 706 590 607 611 680 682 681 683 742 730 725 724 723 722 721 720 719 637 Tyrosine-protein kinase Fes/Fps
TYR FES FES_HUMAN 3CBLA P07332 448 821 822.0 STU:60901,STU:60902,STU:60903 Type1,Allosteric,Allosteric Active DFGin 6.992 14.347 BLAminus -129.39, -161.99 36.63, 77.42 -90.17, 19.41 283.19, 78.42 -59.92, -34.07 in-in in 7.018 Saltbr-in 2.618 HRD-in -73.99, -51.91 78.82, -2.64 in-in-in SNCiii in-in ActLoopNT-in 2.742 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.35, 116.24 APE9-dihe-in -118.34, 122.46 APE8-dihe-in -80.03, 88.22 APE8-rot-na 26.81 APE67-dihe-in -66.64, -12.19 -59.28, -46.73 APE12-dist-na 13.862 APE11-dist-na 9.681 APE10-dist-na 8.625 APE9-dist-in 6.867 None None None XRAY 1.75 0.183 0.227 A 377 354 0 0 0 0 [[561, 816]] 1.0 3cbl TYR_FES_HUMAN TYR 6.6e-94 320.0 1 260 260 700 701 702 704 706 590 607 611 680 682 681 683 742 730 725 724 723 722 721 720 719 637 Tyrosine-protein kinase Fes/Fps
TYR FES FES_HUMAN 3CD3A P07332 448 821 822.0 STU:60901,STU:60902,STU:60903 Type1,Allosteric,Allosteric Active DFGin 7.042 14.319 BLAminus -131.29, -161.96 36.95, 76.94 -87.41, 20.64 283.25, 80.52 -64.77, -30.01 in-in in 6.955 Saltbr-in 2.451 HRD-in -75.66, -48.21 74.09, -7.23 in-in-in SNCiii in-in ActLoopNT-in 2.813 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.76, 114.63 APE9-dihe-in -118.9, 123.98 APE8-dihe-in -79.16, 82.58 APE8-rot-na 23.88 APE67-dihe-in -66.61, -9.96 -49.19, -54.65 APE12-dist-na 14.103 APE11-dist-na 10.043 APE10-dist-na 8.93 APE9-dist-in 7.039 None PTR713 PTR713 XRAY 1.98 0.188 0.247 A 377 351 4 0 0 0 [[561, 816]] 1.0 3cd3 TYR_FES_HUMAN TYR 6.6e-94 320.0 1 260 260 700 701 702 704 706 590 607 611 680 682 681 683 742 730 725 724 723 722 721 720 719 637 Tyrosine-protein kinase Fes/Fps
TYR FYN FYN_HUMAN 2DQ7X P06241 261 523 537.0 STU:60902 Type1 Active DFGin 6.97 13.853 BLAminus -137.79, 173.21 69.46, 82.83 -98.97, 30.24 286.34, 86.38 -56.5, -37.75 in-in in 7.754 Saltbr-in 2.468 HRD-in -90.12, -49.46 72.41, 2.38 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.8, 126.18 APE9-dihe-in -111.81, 159.77 APE8-dihe-in -55.65, 79.81 APE8-rot-na 29.61 APE67-dihe-in -72.56, -28.8 -30.08, -40.64 APE12-dist-na 13.298 APE11-dist-na 8.679 APE10-dist-na 12.457 APE9-dist-in 6.216 None PTR420 PTR420 XRAY 2.8 0.255 0.281 X 283 263 0 0 0 0 [[271, 522]] 1.0 2dq7 TYR_FYN_HUMAN TYR 2.6e-94 321.3 1 260 260 407 408 409 411 413 299 314 318 387 389 388 390 448 436 431 430 429 428 427 426 425 343 Tyrosine-protein kinase Fyn
TYR ITK ITK_HUMAN 1SM2A Q08881 357 619 620.0 STU:301 Type1 Inactive DFGin 5.497 13.321 BLBplus -148.18, -157.96 48.2, 18.11 -92.5, -172.62 59.26, 91.5 71.27, 999.0 out-out out 10.504 Saltbr-out 8.01 HRD-out -81.72, 93.89 -66.35, 12.1 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.52 APE8-rot-na 340.44 APE67-dihe-in -77.92, -11.34 -60.73, -6.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.246 0.292 A 264 245 18 0 0 18 [[363, 614]] 1.0 1sm2 TYR_ITK_HUMAN TYR 9.2e-93 316.2 1 260 260 499 500 501 503 505 391 406 410 479 481 480 482 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SNUA Q08881 357 619 620.0 STU:301 Type1 Inactive DFGin 5.41 13.586 BLBplus -121.03, -147.07 39.99, 19.77 -95.61, 161.03 65.42, 97.15 81.16, 999.0 out-out out 10.985 Saltbr-out 7.73 HRD-out -99.78, 92.32 -72.7, 37.05 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.98 APE8-rot-na 339.02 APE67-dihe-in -71.29, -26.27 -59.31, -15.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.262 0.295 A 264 245 18 0 0 18 [[363, 614]] 1.0 1snu TYR_ITK_HUMAN TYR 9.2e-93 316.2 1 260 260 499 500 501 503 505 391 406 410 479 481 480 482 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SM2B Q08881 358 617 620.0 STU:621 Type1 Inactive DFGin 5.378 13.379 None -126.46, -161.15 38.96, 42.72 -115.58, 999.0 63.86, 78.79 999.0, 999.0 out-out out 11.099 Saltbr-out 6.805 HRD-out -89.1, 89.71 -64.14, 17.77 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 70.78 APE8-rot-na 24.5 APE67-dihe-in -53.23, -18.63 -53.68, -42.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.246 0.292 B 264 241 19 0 0 19 [[363, 614]] 1.0 1sm2 TYR_ITK_HUMAN TYR 9.2e-93 316.2 1 260 260 499 500 501 503 505 391 406 410 479 481 480 482 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SNUB Q08881 358 617 620.0 STU:621 Type1 Inactive DFGin 5.322 13.361 None -135.24, -161.39 47.41, 33.44 -112.08, 999.0 66.07, 77.87 999.0, 999.0 out-out out 11.118 Saltbr-out 7.484 HRD-out -85.26, 96.7 -69.16, 21.34 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 61.67 APE8-rot-na 31.48 APE67-dihe-in -68.53, -31.16 -49.5, -27.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.262 0.295 B 264 241 19 0 0 19 [[363, 614]] 1.0 1snu TYR_ITK_HUMAN TYR 9.2e-93 316.2 1 260 260 499 500 501 503 505 391 406 410 479 481 480 482 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR KIT KIT_HUMAN 8S19A P10721 566 931 976.0 STU:61001 Type1 Active DFGin 7.404 13.667 BLAminus -127.12, -176.58 57.62, 86.03 -104.33, 27.64 287.94, 75.89 -65.62, -32.19 in-in in 8.528 Saltbr-in 2.807 HRD-in -86.95, -44.99 76.04, 4.46 in-in-in SNCiii in-in ActLoopNT-in 2.98 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.78, 135.36 APE9-dihe-in -116.81, 146.55 APE8-dihe-in -80.8, 82.76 APE8-rot-na 31.59 APE67-dihe-in -71.09, -10.53 -60.41, -40.84 APE12-dist-na 14.65 APE11-dist-na 10.007 APE10-dist-na 13.468 APE9-dist-in 7.899 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.3 0.186 0.208 A 327 287 1 0 0 1 [[589, 926]] 1.0 8s19 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 8S19B P10721 566 930 976.0 STU:61001 Type1 Active DFGin 7.327 13.538 BLAminus -128.07, -176.35 62.24, 79.08 -101.65, 27.17 286.46, 78.41 -65.78, -31.3 in-in in 8.424 Saltbr-in 3.244 HRD-in -86.63, -46.82 74.21, 3.84 in-in-in SNCiii in-in ActLoopNT-in 2.972 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.88, 148.22 APE9-dihe-in -128.01, 146.9 APE8-dihe-in -81.2, 79.5 APE8-rot-na 31.77 APE67-dihe-in -74.43, -9.18 -60.72, -38.08 APE12-dist-na 14.121 APE11-dist-na 10.132 APE10-dist-na 13.229 APE9-dist-in 7.695 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.3 0.186 0.208 B 327 284 3 0 0 0 [[589, 926]] 1.0 8s19 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR LCK LCK_HUMAN 1QPJA P06239 236 501 509.0 STU:902 Type1 Active DFGin 6.667 13.91 BLAminus -132.46, 174.81 60.31, 82.59 -95.23, 22.99 299.73, 90.17 -64.21, -26.94 in-in in 8.129 Saltbr-in 2.566 HRD-in -98.38, -45.69 71.81, -4.26 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.6, 145.72 APE9-dihe-in -137.74, 152.71 APE8-dihe-in -60.2, 95.29 APE8-rot-na 326.72 APE67-dihe-in -63.01, -25.44 -48.62, -46.8 APE12-dist-na 14.703 APE11-dist-na 10.092 APE10-dist-na 12.948 APE9-dist-in 7.016 None PTR394 PTR394 XRAY 2.2 0.214 0.267 A 279 266 0 0 0 0 [[245, 496]] 1.0 1qpj TYR_LCK_HUMAN TYR 1.4e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TYR LCK LCK_HUMAN 1QPDA P06239 231 502 509.0 STU:902 Type1 Active DFGin 6.465 14.181 BLAminus -132.18, 176.72 55.71, 84.19 -94.48, 25.19 297.78, 91.73 -59.44, -39.94 in-in in 8.418 Saltbr-in 2.843 HRD-in -101.42, -45.84 73.23, 2.58 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.47, 143.78 APE9-dihe-in -134.7, 155.74 APE8-dihe-in -59.6, 112.24 APE8-rot-na 334.8 APE67-dihe-in -60.08, -21.25 -55.42, -48.02 APE12-dist-na 14.972 APE11-dist-na 10.294 APE10-dist-na 12.967 APE9-dist-in 6.951 None PTR394 PTR394 XRAY 2.0 0.195 0.237 A 279 272 0 0 0 0 [[245, 496]] 1.0 1qpd TYR_LCK_HUMAN TYR 3.6e-93 317.5 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TYR LYN LYN_HUMAN 3A4OX P07948 238 505 512.0 STU:60902 Type1 Inactive DFGin 6.65 15.581 None -103.69, -177.97 54.14, 148.85 -166.58, 42.86 276.85, 106.11 -75.66, -40.91 in-in in 9.123 Saltbr-in 3.22 HRD-in -82.15, -55.06 93.66, -27.17 in-in-out SNCiio in-out ActLoopNT-in 2.861 ActLoopCT-out TYR APEdihe_ooiai APEdist_aaai APE10-dihe-out -155.78, -36.41 APE9-dihe-out 3.09, -67.88 APE8-dihe-in -48.66, 80.66 APE8-rot-na 28.53 APE67-dihe-in -67.02, 39.44 -53.16, -65.62 APE12-dist-na 7.583 APE11-dist-na 3.398 APE10-dist-na 8.537 APE9-dist-in 6.45 None None None XRAY 3.0 0.293 0.324 X 286 259 9 0 0 9 [[247, 499]] 1.0 3a4o TYR_LYN_HUMAN TYR 1.2e-95 325.7 1 260 260 384 385 386 388 390 275 290 294 364 366 365 367 425 413 408 407 406 405 404 403 402 320 Tyrosine-protein kinase Lyn
TYR NTRK1 NTRK1_HUMAN 9DAIA P04629 501 796 796.0 STU:801 Type1 Inactive DFGin 7.329 15.102 None -134.39, -155.28 28.01, 68.03 -73.72, 999.0 288.62, 88.06 999.0, 999.0 in-in in 9.698 Saltbr-in 3.253 HRD-in -62.59, -42.57 78.74, -33.91 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.11 APE8-dihe-in -86.91, 69.17 APE8-rot-na 30.89 APE67-dihe-in -62.36, -34.09 -52.62, -31.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.495 None None None XRAY 2.864 0.22 0.277 A 320 264 32 0 0 19 [[510, 783]] 1.0 9dai TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR SYK KSYK_HUMAN 1XBCA P43405 363 635 635.0 STU:60001 Type1 Active DFGin 6.699 14.236 BLAminus -133.2, -171.25 54.9, 81.04 -97.63, 25.87 287.7, 80.31 -62.67, -30.77 in-in in 8.107 Saltbr-in 2.681 HRD-in -73.91, -54.08 72.64, 5.62 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.93, 102.31 APE9-dihe-in -115.14, 122.86 APE8-dihe-in -77.21, 74.28 APE8-rot-na 27.13 APE67-dihe-in -62.04, -14.77 -51.56, -42.64 APE12-dist-na 10.226 APE11-dist-na 10.661 APE10-dist-na 9.591 APE9-dist-in 6.83 None None None XRAY 2.0 0.246 0.294 A 291 267 6 0 0 0 [[370, 628]] 1.0 1xbc TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR ZAP70 ZAP70_HUMAN 1U59A P43403 328 606 619.0 STU:60100 Type1 Inactive DFGin 6.449 14.655 BLAminus -132.39, 179.54 60.68, 79.94 -93.24, 26.52 286.21, 85.42 -61.36, -30.97 in-in in 8.545 Saltbr-in 2.605 HRD-in -75.34, -52.46 82.3, -36.8 in-in-out SNCiio in-out ActLoopNT-in 2.984 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -109.77, 150.26 APE9-dihe-in -93.67, 137.73 APE8-dihe-in -75.36, 68.87 APE8-rot-na 32.83 APE67-dihe-in -59.55, -7.44 -43.09, -46.01 APE12-dist-na 14.485 APE11-dist-na 13.525 APE10-dist-na 14.7 APE9-dist-out 9.1 None None None XRAY 2.3 0.217 0.271 A 287 276 3 0 0 0 [[338, 595]] 1.0 1u59 TYR_ZAP70_HUMAN TYR 2.5e-90 308.2 6 259 254 478 479 480 482 484 369 386 390 458 460 459 461 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70

Ligand: STU (Staurosporine)

Total number of chains: 131
Active chains: 31
Total number of genes: 47
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 71 54.2% 5E8XA
DFGin ABAminus 21 16.0% 4C34A
DFGin None 19 14.5% 6B1UA
DFGin BLBplus 6 4.6% 7NVQA
DFGin BLBminus 4 3.1% 4EZ7A
None None 4 3.1% 3FMEA
DFGinter BABtrans 3 2.3% 2CLQA
DFGout None 2 1.5% 3D7TB
DFGin BLAplus 1 0.8% 5LOHA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL CTR1 CTR1_ARATH 3PPZA Q05609 540 810 821.0 STU:1 Type1 Active DFGin 7.168 14.176 BLAminus -141.04, 175.37 60.27, 75.13 -95.53, 20.67 299.73, 103.42 -61.37, -41.48 in-in in 9.236 Saltbr-in 3.099 HRD-in -68.66, -37.79 67.09, -5.56 in-in-in SNCiii in-in ActLoopNT-in 3.17 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.6, 161.97 APE9-dihe-na 135.37, 159.66 APE8-dihe-in -74.98, 124.27 APE8-rot-in 310.73 APE67-dihe-in -59.97, -23.72 -59.94, -40.82 APE12-dist-in 7.449 APE11-dist-in 10.756 APE10-dist-in 6.021 APE9-dist-in 3.962 None TPO704,SEP707,SEP710 TPO704,SEP707,SEP710 XRAY 2.99 0.204 0.256 A 309 267 4 0 0 0 [[551, 807]] 1.0 3ppz Arabidopsis thaliana TKL_CTR1_ARATH TKL 5e-79 271.5 2 265 264 693 694 695 697 699 578 596 600 673 675 674 676 733 721 716 715 714 713 712 711 710 626 Serine/threonine-protein kinase CTR1
TKL CTR1 CTR1_ARATH 3P86A Q05609 544 810 821.0 STU:0 Type1 Inactive DFGout 11.699 11.417 None -88.96, 103.02 -108.84, 121.4 -126.5, 999.0 59.02, 88.01 999.0, 999.0 out-out out 11.009 Saltbr-out 6.082 HRD-out -107.29, 93.48 -77.8, -17.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -129.5 APE8-dihe-in -88.96, 138.18 APE8-rot-out 51.6 APE67-dihe-in -62.6, -7.91 -94.5, 4.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.462 D676N None None XRAY 2.496 0.197 0.232 A 309 250 17 0 0 17 [[551, 807]] 1.0 3p86 Arabidopsis thaliana TKL_CTR1_ARATH TKL 3.2e-78 268.9 2 265 264 693 694 695 697 699 578 596 600 673 675 674 676 733 721 716 715 714 713 712 711 710 626 Serine/threonine-protein kinase CTR1
AGC GRK2 ARBK1_BOVIN 8JPBG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.508 12.214 ABAminus -113.28, -56.44 -93.74, 100.06 -93.25, 26.0 307.53, 3.55 -63.32, -43.2 in-out in 8.933 Saltbr-out 4.217 HRD-out -93.17, 87.64 -73.74, -9.71 out-in-in SNCoii in-in ActLoopNT-in 2.726 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.15, 142.89 APE9-dihe-na 142.59, -152.8 APE8-dihe-in -124.3, 137.48 APE8-rot-in 299.05 APE67-dihe-inflip 90.41, -8.27 -58.8, 137.88 APE12-dist-in 9.902 APE11-dist-in 12.01 APE10-dist-in 6.099 APE9-dist-in 3.63 A292P,R295I,S455D None None EM 3.07 999.0 999.0 G 688 658 0 0 0 0 [[191, 453]] 1.0 8jpb Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 8JPCG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.385 12.157 ABAminus -113.22, -56.58 -93.6, 101.44 -93.44, 27.48 306.81, 9.79 -63.79, -45.14 in-out in 8.989 Saltbr-out 4.654 HRD-out -92.62, 94.67 -75.66, -35.58 out-in-in SNCoii in-in ActLoopNT-in 2.653 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.27, 130.92 APE9-dihe-na 162.84, -151.71 APE8-dihe-in -129.7, 130.81 APE8-rot-in 302.62 APE67-dihe-inflip 97.48, -17.5 -57.09, 134.46 APE12-dist-in 9.713 APE11-dist-in 11.989 APE10-dist-in 5.989 APE9-dist-in 4.316 A292P,R295I,S455D None None EM 3.07 999.0 999.0 G 688 658 0 0 0 0 [[191, 453]] 1.0 8jpc Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 8JPDG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.385 12.157 ABAminus -113.24, -56.55 -93.57, 101.39 -93.42, 27.53 306.84, 9.79 -63.78, -45.12 in-out in 8.989 Saltbr-out 4.653 HRD-out -92.61, 94.65 -75.65, -35.58 out-in-in SNCoii in-in ActLoopNT-in 2.653 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.32, 130.92 APE9-dihe-na 162.83, -151.7 APE8-dihe-in -129.72, 130.82 APE8-rot-in 302.58 APE67-dihe-inflip 97.48, -17.49 -57.11, 134.43 APE12-dist-in 9.714 APE11-dist-in 11.989 APE10-dist-in 5.989 APE9-dist-in 4.317 A292P,R295I,S455D None None EM 2.81 999.0 999.0 G 688 658 0 0 0 0 [[191, 453]] 1.0 8jpd Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC PRKACA KAPCA_BOVIN 1STCE P00517 16 351 351.0 STU:60351 Type1 Inactive DFGin 6.125 14.676 ABAminus -152.28, -21.25 -98.94, 113.28 -112.23, 27.12 284.07, 102.64 -65.61, -29.61 in-in in 9.174 Saltbr-in 2.608 HRD-out -84.15, -57.61 42.07, 55.99 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.84, 156.46 APE9-dihe-na 129.45, -158.0 APE8-dihe-in -121.73, 124.56 APE8-rot-in 292.46 APE67-dihe-in -75.12, -21.46 -28.7, -46.78 APE12-dist-in 8.387 APE11-dist-in 11.162 APE10-dist-in 5.826 APE9-dist-in 4.443 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.3 0.208 0.33 E 350 336 0 0 0 0 [[44, 298]] 1.0 1stc Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 4C34A P00517 11 351 351.0 STU:61351 Type1 Inactive DFGin 6.517 14.849 ABAminus -119.31, -40.44 -98.64, 112.68 -107.28, 23.29 283.36, 88.13 -59.12, -19.89 in-in in 8.864 Saltbr-in 2.985 HRD-in -78.06, -54.1 69.84, 7.38 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.66, 162.66 APE9-dihe-na 118.12, -166.39 APE8-dihe-in -111.07, 134.19 APE8-rot-in 303.77 APE67-dihe-in -56.72, -26.94 -46.04, -52.13 APE12-dist-in 8.398 APE11-dist-in 11.458 APE10-dist-in 5.765 APE9-dist-in 3.408 F55Y,M121L,V124L,L174M,Q182K SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.78 0.18 0.214 A 351 340 0 0 0 0 [[44, 298]] 1.0 4c34 Bos taurus AGC_PRKACA_BOVIN AGC 7.8e-94 319.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
TYR SRC SRC_CHICK 3D7TB P00523 258 533 533.0 STU:6334 Type1 Inactive DFGout 12.814 10.121 None -137.48, -160.64 -79.66, 41.23 -140.31, 108.32 334.97, 53.33 120.28, -36.98 in-in in 8.029 Saltbr-in 2.622 HRD-in -81.72, -43.05 80.64, -35.93 in-out-none SNCion out-none ActLoopNT-out 5.413 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 102.99 APE9-dihe-in -85.23, 141.01 APE8-dihe-in -81.53, 111.41 APE8-rot-na 348.05 APE67-dihe-in -53.4, -28.51 -45.34, -53.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.29 APE9-dist-in 5.671 None None None XRAY 2.899 0.239 0.278 B 286 265 11 0 0 11 [[267, 518]] 1.0 3d7t Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
AGC MASTL GWL_HUMAN 5LOHA Q96GX5 30 854 879.0 STU:60901 Type1 Inactive DFGin 10.84 13.519 BLAplus -154.04, -179.93 62.84, 37.43 -106.51, -23.39 59.72, 80.58 -168.74, -25.48 none-none none 999.0 Saltbr-none 999.0 HRD-in -59.31, -45.76 66.7, 4.42 none-out-out SNCnoo out-out ActLoopNT-out 8.33 ActLoopCT-out nonTYR APEdihe_aanon APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 165.16 APE8-dihe-none -79.14, 999.0 APE8-rot-out 44.79 APE67-dihe-none -72.42, -27.62 999.0, 33.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.891 None None None XRAY 3.1 0.209 0.265 A 341 246 34 0 0 15 [[35, 835]] 1.0 5loh Homo sapiens AGC_MASTL_HUMAN AGC 4e-131 441.8 1 260 260 173 174 175 177 179 62 81 85 153 155 154 156 760 201 196 195 741 740 -9999 -9999 -9999 111 Serine/threonine-protein kinase greatwall
AGC MASTL GWL_HUMAN 5LOHB Q96GX5 30 854 879.0 STU:60901 Type1 Inactive None 999.0 13.339 None -152.85, -174.25 66.27, 69.27 -150.61, -21.46 41.33, 82.81 -90.34, 22.29 none-none none 999.0 Saltbr-none 999.0 HRD-in -60.11, -44.59 64.53, 4.15 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aannn APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -141.8 APE8-dihe-none -77.31, 999.0 APE8-rot-none 999.0 APE67-dihe-none 49.84, -65.93 999.0, -82.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.713 None None None XRAY 3.1 0.209 0.265 B 341 250 30 0 0 17 [[35, 835]] 1.0 5loh Homo sapiens AGC_MASTL_HUMAN AGC 4e-131 441.8 1 260 260 173 174 175 177 179 62 81 85 153 155 154 156 760 201 196 195 741 740 -9999 -9999 -9999 111 Serine/threonine-protein kinase greatwall
AGC PDPK1 PDPK1_HUMAN 1OKYA O15530 72 360 556.0 STU:1368 Type1 Inactive DFGin 6.153 14.462 BLAminus -148.97, -170.84 70.56, 80.45 -102.75, 23.82 286.84, 96.04 -69.28, -20.21 in-in in 8.672 Saltbr-in 2.673 HRD-in -67.69, -57.78 80.28, 0.43 in-in-out SNCiio in-out ActLoopNT-in 2.934 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.7, -80.59 APE9-dihe-na 115.49, 169.91 APE8-dihe-in -54.49, 123.73 APE8-rot-in 316.76 APE67-dihe-in -63.35, -17.55 -42.07, -50.54 APE12-dist-in 9.289 APE11-dist-out 5.556 APE10-dist-out 9.719 APE9-dist-in 4.222 None SEP241 SEP241 XRAY 2.3 0.219 0.255 A 310 283 6 0 0 6 [[82, 342]] 1.0 1oky Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PRKCQ KPCT_HUMAN 1XJDA Q04759 377 696 706.0 STU:200 Type1 Active DFGin 5.828 13.193 BLAminus -132.69, 162.8 69.28, 95.13 -109.8, 21.13 305.67, 104.94 -64.79, -17.76 in-in in 8.064 Saltbr-in 2.513 HRD-in -67.27, -48.59 64.56, -1.72 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.73, 166.78 APE9-dihe-na 120.3, 163.8 APE8-dihe-in -75.86, 125.98 APE8-rot-in 298.87 APE67-dihe-in -57.15, -29.94 -38.43, -48.34 APE12-dist-in 9.03 APE11-dist-in 12.294 APE10-dist-in 6.896 APE9-dist-in 3.767 None TPO538,SEP695 TPO538,SEP695 XRAY 2.0 0.201 0.216 A 345 282 0 0 0 0 [[380, 634]] 1.0 1xjd Homo sapiens AGC_PRKCQ_HUMAN AGC 1.2e-95 325.5 1 260 260 521 522 523 525 527 409 428 432 501 503 502 504 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC RPS6KA1-1 KS6A1_HUMAN 2Z7RA Q15418 53 340 735.0 STU:1 Type1 Inactive DFGin 6.928 12.322 BLBplus -135.18, 169.76 58.7, 61.01 -129.8, -169.31 56.27, 83.01 123.62, -72.1 none-none none 999.0 Saltbr-none 999.0 HRD-out -70.75, 75.42 -55.39, -34.53 none-out-out SNCnoo out-out ActLoopNT-out 7.378 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.4 APE8-dihe-in -65.4, 109.6 APE8-rot-in 309.27 APE67-dihe-in -55.68, -21.45 -56.7, -41.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.754 None None None XRAY 2.0 0.255 0.286 A 321 265 23 0 0 12 [[62, 321], [418, 675]] 2.0 2z7r Homo sapiens AGC_RPS6KA1-1_HUMAN AGC 1.5e-95 325.1 1 260 260 204 205 206 208 210 94 112 116 184 186 185 187 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
AGC RPS6KB1 KS6B1_HUMAN 3A62A P23443 85 372 525.0 STU:400 Type1 Inactive DFGin 6.524 14.117 ABAminus -137.83, -32.54 -98.98, 101.69 -111.0, 24.18 305.63, 93.27 -75.95, -178.42 in-in in 8.238 Saltbr-in 2.912 HRD-in -88.81, -24.52 69.43, -47.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -65.23, -49.64 APE9-dihe-na -102.67, -164.37 APE8-dihe-in -63.46, 142.22 APE8-rot-out 175.82 APE67-dihe-in -68.79, -14.76 -111.61, 8.72 APE12-dist-in 10.247 APE11-dist-in 13.136 APE10-dist-out 9.309 APE9-dist-out 11.608 None TPO252 TPO252 XRAY 2.35 0.229 0.272 A 327 264 24 0 0 10 [[91, 352]] 1.0 3a62 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A60A P23443 85 371 525.0 STU:400 Type1 Inactive DFGin 6.157 13.694 None -106.91, -67.93 -78.35, 124.27 -119.68, -133.11 293.51, 79.75 162.78, -54.12 in-out in 7.754 Saltbr-out 3.905 HRD-in -63.83, -43.18 73.78, -30.83 out-out-none SNCoon out-none ActLoopNT-out 3.673 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -74.9 APE8-rot-in 297.46 APE67-dihe-in -54.54, -22.69 -86.47, -11.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.21 0.268 A 327 263 24 0 0 13 [[91, 352]] 1.0 3a60 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A61A P23443 87 371 525.0 STU:400 Type1 Inactive DFGin 5.812 13.405 None -134.05, -75.4 -81.48, 111.28 -98.21, -179.91 302.65, 80.45 -119.91, 999.0 in-in in 7.863 Saltbr-in 3.459 HRD-in -91.01, -26.19 64.38, -56.51 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -70.31 APE8-dihe-in -167.04, 106.84 APE8-rot-out 166.31 APE67-dihe-in -54.66, 20.97 -86.85, -22.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.963 None None None XRAY 3.43 0.274 0.349 A 327 254 31 0 0 16 [[91, 352]] 1.0 3a61 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 4RLOB P23443 85 372 525.0 STU:401 Type1 Inactive None 999.0 7.196 None -86.75, 160.35 -107.62, 22.98 -156.62, 162.78 69.29, 88.54 159.5, 162.01 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.31, -49.02 69.03, -42.5 none-out-out SNCnoo out-out ActLoopNT-out 4.816 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 152.17 APE8-rot-out 189.44 APE67-dihe-in -65.44, -8.07 -124.54, 4.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.527 0.193 0.222 B 288 254 34 0 0 11 [[91, 352]] 1.0 4rlo Homo sapiens AGC_RPS6KB1_HUMAN AGC 2.9e-96 327.5 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A60B P23443 85 372 525.0 STU:401 Type1 Inactive None 999.0 9.181 None -122.3, -155.7 -144.9, 63.43 -46.62, 179.79 231.81, 121.03 -99.91, 37.09 none-none none 999.0 Saltbr-none 999.0 HRD-in -85.46, -48.18 73.35, -54.05 none-in-out SNCnio in-out ActLoopNT-in 2.865 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -2.69 APE9-dihe-na -82.95, -88.68 APE8-dihe-in -146.72, 128.75 APE8-rot-out 80.81 APE67-dihe-in -72.02, 1.17 -100.99, 0.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 29.777 APE9-dist-out 31.967 None None None XRAY 2.8 0.21 0.268 B 327 255 33 0 0 10 [[91, 352]] 1.0 3a60 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC STK32A ST32A_HUMAN 4FR4A Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 6.958 14.55 BLAminus -131.26, -171.36 55.81, 77.24 -91.39, 23.54 282.26, 68.76 -52.72, -37.5 in-out in 9.45 Saltbr-out 4.405 HRD-in -80.59, -48.19 75.72, 1.95 out-in-in SNCoii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.54, 125.66 APE9-dihe-na 163.36, -179.6 APE8-dihe-in -98.31, 118.28 APE8-rot-in 302.74 APE67-dihe-in -69.16, -7.09 -58.36, -42.03 APE12-dist-in 9.984 APE11-dist-in 11.7 APE10-dist-in 6.037 APE9-dist-in 3.577 None None None XRAY 2.29 0.206 0.244 A 384 350 0 0 0 0 [[23, 281]] 1.0 4fr4 Homo sapiens AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4B Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 7.004 14.665 BLAminus -130.94, -173.3 57.57, 78.46 -91.73, 35.47 281.68, 71.64 -62.72, -37.53 in-out in 9.523 Saltbr-out 4.678 HRD-in -83.22, -47.99 75.33, -2.43 out-in-in SNCoii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.47, 130.4 APE9-dihe-na 159.4, 177.51 APE8-dihe-in -93.68, 119.81 APE8-rot-in 304.76 APE67-dihe-in -71.88, -7.25 -60.98, -38.06 APE12-dist-in 10.024 APE11-dist-in 11.735 APE10-dist-in 6.019 APE9-dist-in 3.57 None None None XRAY 2.29 0.206 0.244 B 384 350 0 0 0 0 [[23, 281]] 1.0 4fr4 Homo sapiens AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4C Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 6.95 14.697 BLAminus -132.52, -169.93 52.69, 78.95 -90.58, 33.35 282.07, 69.09 -66.67, -30.48 in-out in 9.538 Saltbr-out 4.652 HRD-in -81.16, -46.81 73.79, 0.59 out-in-in SNCoii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.08, 126.04 APE9-dihe-na 163.32, 177.32 APE8-dihe-in -92.37, 117.65 APE8-rot-in 306.61 APE67-dihe-in -71.09, -9.62 -57.49, -40.3 APE12-dist-in 9.986 APE11-dist-in 11.719 APE10-dist-in 6.031 APE9-dist-in 3.569 None None None XRAY 2.29 0.206 0.244 C 384 344 0 0 0 0 [[23, 281]] 1.0 4fr4 Homo sapiens AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4D Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 6.968 14.54 BLAminus -131.99, -171.7 54.78, 77.72 -90.01, 30.97 282.82, 68.36 -59.09, -35.1 in-out in 9.54 Saltbr-out 4.111 HRD-in -82.23, -46.79 74.71, 0.05 out-in-in SNCoii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.67, 126.06 APE9-dihe-na 163.38, 179.82 APE8-dihe-in -95.08, 119.14 APE8-rot-in 303.5 APE67-dihe-in -68.68, -8.82 -58.5, -42.47 APE12-dist-in 10.028 APE11-dist-in 11.674 APE10-dist-in 5.978 APE9-dist-in 3.621 None None None XRAY 2.29 0.206 0.244 D 384 346 0 0 0 0 [[23, 281]] 1.0 4fr4 Homo sapiens AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4E Q8WU08 14 372 396.0 STU:401 Type1 Inactive DFGin 6.929 14.69 BLAminus -131.82, -175.27 57.96, 79.76 -93.48, 35.37 282.42, 66.15 -67.02, -30.68 in-out in 9.559 Saltbr-out 4.667 HRD-in -80.84, -48.94 74.6, -0.56 out-in-in SNCoii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.84, 126.86 APE9-dihe-na 161.76, 179.6 APE8-dihe-in -94.71, 118.0 APE8-rot-in 302.52 APE67-dihe-in -65.82, -9.98 -56.35, -43.97 APE12-dist-in 10.033 APE11-dist-in 11.753 APE10-dist-in 6.011 APE9-dist-in 3.555 None None None XRAY 2.29 0.206 0.244 E 384 342 0 0 0 0 [[23, 281]] 1.0 4fr4 Homo sapiens AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4F Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 6.922 14.48 BLAminus -133.24, -172.46 54.73, 79.35 -94.14, 35.98 283.65, 67.48 -61.74, -33.87 in-out in 9.458 Saltbr-out 4.459 HRD-in -80.63, -46.14 70.35, 4.86 out-in-in SNCoii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.84, 129.22 APE9-dihe-na 160.43, 179.28 APE8-dihe-in -96.01, 118.11 APE8-rot-in 307.21 APE67-dihe-in -68.52, -8.52 -57.81, -41.21 APE12-dist-in 10.007 APE11-dist-in 11.703 APE10-dist-in 5.986 APE9-dist-in 3.587 None None None XRAY 2.29 0.206 0.244 F 384 346 0 0 0 0 [[23, 281]] 1.0 4fr4 Homo sapiens AGC_STK32A_HUMAN AGC 7.7e-84 287.1 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
CAMK CHEK1 CHK1_HUMAN 1NVRA O14757 3 273 476.0 STU:400 Type1 Active DFGin 7.007 14.466 BLAminus -138.12, 170.91 63.58, 88.44 -97.82, 26.51 284.37, 82.9 -65.94, -21.37 in-in in 8.834 Saltbr-in 3.325 HRD-in -77.73, -42.26 72.42, 0.07 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.96, 168.99 APE9-dihe-na 123.47, -148.6 APE8-dihe-in -135.84, 118.76 APE8-rot-in 301.9 APE67-dihe-in -60.54, -22.99 -38.52, -52.15 APE12-dist-in 8.986 APE11-dist-in 11.773 APE10-dist-in 6.22 APE9-dist-in 3.344 None None None XRAY 1.8 0.193 0.226 A 289 264 7 0 0 0 [[9, 265]] 1.0 1nvr Homo sapiens CAMK_CHEK1_HUMAN CAMK 2.6e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7AKOA O14757 2 271 476.0 STU:60301 Type1 Active DFGin 7.258 14.346 BLAminus -129.99, 164.38 63.12, 90.57 -95.99, 30.1 286.66, 77.28 -66.31, -26.96 in-in in 8.834 Saltbr-in 2.687 HRD-in -79.3, -45.9 76.54, 2.66 in-in-in SNCiii in-in ActLoopNT-in 2.999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.15, 172.04 APE9-dihe-na 107.34, -156.22 APE8-dihe-in -136.58, 123.75 APE8-rot-in 305.71 APE67-dihe-in -59.04, -20.83 -49.6, -50.22 APE12-dist-in 8.951 APE11-dist-in 11.921 APE10-dist-in 6.385 APE9-dist-in 3.572 D10R None None XRAY 1.8 0.192 0.235 A 300 270 0 0 0 0 [[9, 265]] 1.0 7ako Homo sapiens CAMK_CHEK1_HUMAN CAMK 3.4e-71 245.5 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7AKOB O14757 2 271 476.0 STU:60301 Type1 Active DFGin 7.037 14.527 BLAminus -133.06, 166.86 60.65, 91.44 -101.1, 26.21 287.91, 78.35 -62.72, -24.94 in-in in 9.183 Saltbr-in 3.404 HRD-in -77.35, -44.25 76.09, 6.63 in-in-in SNCiii in-in ActLoopNT-in 3.039 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.79, 168.24 APE9-dihe-na 123.14, -149.89 APE8-dihe-in -132.89, 126.1 APE8-rot-in 304.27 APE67-dihe-in -62.82, -10.87 -52.63, -48.98 APE12-dist-in 8.63 APE11-dist-in 11.884 APE10-dist-in 6.247 APE9-dist-in 3.495 D10R None None XRAY 1.8 0.192 0.235 B 300 270 0 0 0 0 [[9, 265]] 1.0 7ako Homo sapiens CAMK_CHEK1_HUMAN CAMK 3.4e-71 245.5 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5OORA O14757 3 283 476.0 STU:301 Type1 Inactive DFGin 7.196 13.603 BLAminus -121.08, 157.07 78.53, 94.76 -101.65, 21.08 291.71, 78.34 -70.5, -20.28 in-out in 9.325 Saltbr-out 5.381 HRD-in -78.63, -43.76 73.29, -4.94 out-in-in SNCoii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.81, 173.83 APE9-dihe-na 115.52, -146.73 APE8-dihe-in -140.31, 116.76 APE8-rot-in 299.43 APE67-dihe-in -68.59, -17.99 -48.27, -41.97 APE12-dist-in 9.154 APE11-dist-in 11.744 APE10-dist-in 6.296 APE9-dist-in 3.597 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.9 0.167 0.208 A 297 273 8 0 0 0 [[9, 265]] 1.0 5oor Homo sapiens CAMK_CHEK1_HUMAN CAMK 4.8e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK DAPK1 DAPK1_HUMAN 1WVYA P53355 4 276 1430.0 STU:1001 Type1 Inactive DFGin 6.742 14.293 ABAminus -89.35, -23.12 -108.72, 148.84 -138.39, 21.2 279.12, 93.85 -56.2, -46.66 in-in in 9.453 Saltbr-in 2.791 HRD-in -70.14, -42.49 63.36, 7.4 in-in-out SNCiio in-out ActLoopNT-in 2.757 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -134.32, 148.67 APE9-dihe-na -105.19, -133.62 APE8-dihe-in -62.12, 122.93 APE8-rot-in 303.72 APE67-dihe-in -56.52, -27.75 -50.01, -41.98 APE12-dist-in 10.349 APE11-dist-out 5.638 APE10-dist-out 8.762 APE9-dist-in 4.974 None None None XRAY 2.8 0.222 0.274 A 278 273 0 0 0 0 [[13, 275]] 1.0 1wvy Homo sapiens CAMK_DAPK1_HUMAN CAMK 5e-95 323.6 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK MAPKAPK2 MAPK2_HUMAN 2PZYC P49137 42 359 400.0 STU:3 Type1 None DFGin 4.742 13.584 BLAminus -137.32, 155.33 89.76, 83.85 -93.67, 22.39 287.9, 52.26 -71.67, 3.21 in-in in 8.899 Saltbr-in 2.479 HRD-in -82.26, -44.82 71.63, -15.61 in-in-none SNCiin in-none ActLoopNT-in 2.823 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -81.01, -7.47 999.0, -140.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.251 0.313 C 324 307 11 0 0 11 [[63, 325]] 1.0 2pzy Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKA P49137 42 345 400.0 STU:401 Type1 None DFGin 4.829 13.428 BLAminus -122.05, -170.73 42.15, 101.84 -103.58, 19.28 282.18, 65.24 -58.03, -23.15 in-in in 8.716 Saltbr-in 2.473 HRD-in -79.4, -39.47 62.13, 0.83 in-in-none SNCiin in-none ActLoopNT-in 2.683 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -71.16, 3.04 999.0, 148.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 A 400 290 14 0 0 11 [[63, 325]] 1.0 1nxk Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKB P49137 44 345 400.0 STU:403 Type1 None DFGin 4.577 13.822 BLAminus -128.27, 177.79 53.09, 103.0 -104.87, 20.3 276.49, 67.38 -57.0, -14.43 in-in in 8.647 Saltbr-in 2.563 HRD-in -64.22, -46.2 66.47, 1.25 in-in-none SNCiin in-none ActLoopNT-in 2.82 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.0, -19.87 999.0, 111.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 B 400 283 19 0 0 11 [[63, 325]] 1.0 1nxk Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKC P49137 41 357 400.0 STU:401 Type1 None DFGin 4.963 13.774 BLAminus -132.89, 178.15 57.47, 93.76 -100.34, 25.49 283.43, 65.32 -70.88, 11.4 in-in in 8.684 Saltbr-in 2.34 HRD-in -75.36, -47.72 65.17, 8.17 in-in-none SNCiin in-none ActLoopNT-in 2.982 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.28, 2.34 999.0, 115.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 C 400 306 11 0 0 11 [[63, 325]] 1.0 1nxk Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKD P49137 43 342 400.0 STU:401 Type1 Inactive DFGin 4.831 13.91 BLAminus -136.01, 172.45 58.97, 96.18 -97.02, 30.62 280.59, 64.96 -55.97, -37.81 in-in in 8.803 Saltbr-in 2.649 HRD-in -61.55, -54.52 76.31, -8.43 in-in-out SNCiio in-out ActLoopNT-in 3.004 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, 21.79 APE9-dihe-na -95.93, -89.71 APE8-dihe-out 87.4, 89.72 APE8-rot-in 304.66 APE67-dihe-out -57.06, -12.13 -63.98, 136.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 30.487 APE9-dist-out 33.331 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 D 400 288 12 0 0 8 [[63, 325]] 1.0 1nxk Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MKNK2 MKNK2_HUMAN 2HW7A Q9HBH9 72 371 465.0 STU:60031 Type1 Inactive DFGin 4.905 14.123 BLBplus -153.19, 172.78 68.05, 27.15 -77.7, 175.81 23.89, 67.82 81.52, 999.0 in-in in 8.993 Saltbr-in 2.903 HRD-in -73.6, -55.95 77.37, -18.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 26.54 APE8-dihe-out -84.42, -14.4 APE8-rot-in 301.04 APE67-dihe-in -61.16, -21.76 -49.65, -47.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 33.47 D228G None None XRAY 2.71 0.203 0.246 A 316 269 31 0 0 23 [[83, 368]] 1.0 2hw7 Homo sapiens CAMK_MKNK2_HUMAN CAMK 8e-79 270.5 1 256 256 225 226 227 229 231 113 129 133 202 204 203 205 277 260 255 254 253 252 251 250 249 160 MAP kinase-interacting serine/threonine-protein kinase 2
CAMK PIM1 PIM1_HUMAN 1YHSA P11309 33 305 313.0 STU:306 Type1 Active DFGin 6.361 14.512 BLAminus -129.35, 165.16 65.09, 87.92 -99.2, 21.71 283.47, 69.45 -67.38, -11.76 in-in in 8.524 Saltbr-in 2.899 HRD-na-A -65.05, -49.56 68.79, 3.6 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.4, 26.1 APE9-dihe-na -84.03, -156.82 APE8-dihe-in -85.78, 122.63 APE8-rot-in 304.34 APE67-dihe-in -62.69, -6.01 -56.85, -49.38 APE12-dist-in 9.327 APE11-dist-in 8.52 APE10-dist-in 5.508 APE9-dist-in 3.832 None SEP261 CME161,SEP261 XRAY 2.15 0.233 0.233 A 273 269 4 0 0 0 [[38, 290]] 1.0 1yhs Homo sapiens CAMK_PIM1_HUMAN CAMK 2.4e-65 226.3 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PRKAA1 AAPK1_HUMAN 6C9FA Q13131 22 558 559.0 R34:60601,STU:60602 Allosteric,Type1 Inactive DFGin 6.728 14.295 ABAminus -116.49, -61.55 -94.26, 110.71 -99.52, 6.4 287.66, 85.72 -50.13, -39.13 out-out out 10.713 Saltbr-out 5.319 HRD-in -66.33, -58.11 53.99, 16.31 out-in-out SNCoio in-out ActLoopNT-in 2.771 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.89, 155.28 APE9-dihe-na 94.11, 171.31 APE8-dihe-in -69.7, 144.51 APE8-rot-out 175.9 APE67-dihe-in -64.59, -37.19 -54.17, -35.84 APE12-dist-in 8.268 APE11-dist-in 10.73 APE10-dist-in 5.149 APE9-dist-in 4.237 None TPO183 TPO183 XRAY 2.924 0.229 0.245 A 494 371 0 0 0 0 [[27, 279]] 1.0 6c9f Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 6C9GA Q13131 22 558 559.0 R93:60601,STU:60602 Allosteric,Type1 Inactive DFGin 6.907 14.399 BLAminus -135.02, 170.21 60.34, 77.63 -85.45, 11.43 285.05, 75.57 -50.8, -32.37 out-out out 10.695 Saltbr-out 5.597 HRD-in -79.11, -48.44 68.49, -16.14 out-in-out SNCoio in-out ActLoopNT-in 2.877 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -145.15, 158.83 APE9-dihe-na 72.57, 174.42 APE8-dihe-in -69.04, 143.86 APE8-rot-out 162.73 APE67-dihe-in -62.81, -32.14 -55.18, -38.62 APE12-dist-in 8.45 APE11-dist-in 11.031 APE10-dist-in 6.008 APE9-dist-in 4.009 None TPO183 TPO183 XRAY 2.7 0.205 0.24 A 494 384 0 0 0 0 [[27, 279]] 1.0 6c9g Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 6C9HA Q13131 22 558 559.0 R34:60601,STU:60602 Allosteric,Type1 Inactive DFGin 6.712 14.382 BLAminus -138.26, 171.2 60.5, 73.75 -84.01, 6.76 285.61, 85.73 -48.49, -36.53 out-out out 10.649 Saltbr-out 5.631 HRD-in -69.22, -48.97 68.92, -5.29 out-in-out SNCoio in-out ActLoopNT-in 3.017 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -142.6, 158.62 APE9-dihe-na 60.32, -132.0 APE8-dihe-in -130.57, 153.41 APE8-rot-out 177.79 APE67-dihe-in -63.0, -34.49 -63.07, -41.05 APE12-dist-in 8.655 APE11-dist-in 10.618 APE10-dist-in 6.189 APE9-dist-in 3.873 None None None XRAY 2.65 0.215 0.242 A 494 433 0 0 0 0 [[27, 279]] 1.0 6c9h Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 6C9JA Q13131 22 559 559.0 R34:60601,STU:60602 Allosteric,Type1 Active DFGin 6.98 13.932 BLAminus -148.31, -179.86 61.68, 68.06 -82.96, 8.26 285.07, 89.54 -49.65, -37.12 out-in out 10.05 Saltbr-in 3.025 HRD-in -61.18, -61.45 68.18, -7.34 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.03, 155.55 APE9-dihe-na 81.79, 170.06 APE8-dihe-in -65.93, 140.22 APE8-rot-in 298.24 APE67-dihe-in -65.83, -31.14 -52.06, -38.38 APE12-dist-in 8.312 APE11-dist-in 11.199 APE10-dist-in 5.64 APE9-dist-in 4.101 None TPO183 TPO183 XRAY 3.05 0.215 0.225 A 494 384 0 0 0 0 [[27, 279]] 1.0 6c9j Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.7e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 4RERA Q13131 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.724 14.682 None -104.41, -74.44 -70.58, 123.21 -111.45, 7.12 271.34, 95.59 -64.34, -25.66 in-in in 9.394 Saltbr-in 3.168 HRD-out -106.73, 104.09 -76.93, -37.65 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.23, 162.43 APE9-dihe-na 109.76, -176.61 APE8-dihe-in -65.38, 159.16 APE8-rot-in 282.67 APE67-dihe-in -82.84, -28.7 -67.98, -40.26 APE12-dist-in 8.764 APE11-dist-in 11.102 APE10-dist-in 5.353 APE9-dist-in 4.566 E480G,E483A,K485A TPO183 TPO183 XRAY 4.047 0.227 0.26 A 540 459 0 0 0 0 [[27, 279]] 1.0 4rer Homo sapiens CAMK_PRKAA1_HUMAN CAMK 8.5e-89 303.4 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 4REWA Q13131 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.282 14.445 None -106.98, -78.3 -79.98, 116.66 -98.66, 4.74 266.69, 106.69 -52.57, -49.44 out-out out 10.894 Saltbr-out 4.849 HRD-out -91.4, 104.28 -79.59, -35.51 out-in-out SNCoio in-out ActLoopNT-in 2.949 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -146.3, 177.71 APE9-dihe-na 92.22, 179.97 APE8-dihe-in -62.77, 176.84 APE8-rot-in 309.53 APE67-dihe-in -79.73, -37.36 -85.43, -26.86 APE12-dist-in 9.032 APE11-dist-in 10.912 APE10-dist-in 6.074 APE9-dist-out 7.166 E480G,E483A,K485A None None XRAY 4.58 0.234 0.259 A 540 411 0 0 0 0 [[27, 279]] 1.0 4rew Homo sapiens CAMK_PRKAA1_HUMAN CAMK 8.5e-89 303.4 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA2 AAPK2_HUMAN 5ISOA P54646 9 551 552.0 STU:601,992:602 Type1,Allosteric Inactive DFGin 7.076 13.754 ABAminus -124.01, -69.61 -91.71, 113.8 -98.34, 8.3 284.02, 83.8 -52.09, -32.8 out-none out 10.676 Saltbr-none 999.0 HRD-in -77.82, -48.64 73.79, -15.56 none-in-out SNCnio in-out ActLoopNT-in 3.07 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -153.96, 161.46 APE9-dihe-na 108.89, 175.81 APE8-dihe-in -73.92, 127.97 APE8-rot-out 47.66 APE67-dihe-in -62.08, -29.52 -54.52, -36.25 APE12-dist-in 8.114 APE11-dist-in 11.355 APE10-dist-in 6.596 APE9-dist-in 5.039 None None None XRAY 2.63 0.18 0.23 A 552 453 0 0 0 0 [[16, 268]] 1.0 5iso Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.1e-89 306.3 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5ISOC P54646 9 550 552.0 STU:601,992:602 Type1,Allosteric Inactive DFGin 7.185 14.12 ABAminus -118.95, -64.95 -97.93, 114.29 -100.77, 6.08 282.8, 83.31 -57.51, -20.09 out-none out 10.921 Saltbr-none 999.0 HRD-in -73.97, -50.71 73.94, -15.38 none-in-out SNCnio in-out ActLoopNT-in 3.026 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.17, 145.11 APE9-dihe-na 105.06, -178.93 APE8-dihe-in -75.45, 134.7 APE8-rot-out 182.56 APE67-dihe-in -57.91, -29.21 -54.57, -40.7 APE12-dist-in 9.015 APE11-dist-in 11.223 APE10-dist-in 5.424 APE9-dist-in 4.301 None None None XRAY 2.63 0.18 0.23 C 552 429 0 0 0 0 [[16, 268]] 1.0 5iso Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.1e-89 306.3 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 6B1UC P54646 9 552 552.0 STU:60601,CG7:60602 Type1,Allosteric Inactive DFGin 7.452 14.13 ABAminus -133.95, -50.46 -79.36, 100.93 -96.81, 22.67 283.51, 87.03 -67.96, -35.6 out-out out 10.247 Saltbr-out 4.344 HRD-in -62.69, -52.12 64.78, 6.12 out-in-out SNCoio in-out ActLoopNT-in 3.031 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 59.85, -130.04 APE9-dihe-na -84.76, -170.01 APE8-dihe-in -60.51, 139.79 APE8-rot-out 157.81 APE67-dihe-in -64.49, -24.93 -66.94, -29.94 APE12-dist-in 7.802 APE11-dist-in 10.102 APE10-dist-in 6.076 APE9-dist-in 4.423 None TPO172 TPO172 XRAY 2.77 0.196 0.226 C 565 460 0 0 0 0 [[16, 268]] 1.0 6b1u Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFFA P54646 8 551 552.0 STU:61552 Type1 Inactive DFGin 7.056 14.082 BLAminus -149.77, 179.95 57.3, 81.92 -95.29, 37.99 289.6, 92.87 -75.43, -19.2 out-out out 10.989 Saltbr-out 5.616 HRD-out -79.02, 102.38 -90.23, 5.49 out-in-out SNCoio in-out ActLoopNT-in 3.106 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -140.4, 154.3 APE9-dihe-na 120.73, -179.28 APE8-dihe-in -68.72, 155.02 APE8-rot-out 179.49 APE67-dihe-out -92.39, 175.4 -57.6, -33.75 APE12-dist-in 7.952 APE11-dist-in 11.177 APE10-dist-in 5.554 APE9-dist-in 3.902 None TPO172 TPO172 XRAY 3.924 0.211 0.264 A 571 425 0 0 0 0 [[16, 268]] 1.0 4cff Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 8BIKA P54646 8 551 552.0 STU:61001,QTN:61002 Type1,Allosteric Inactive DFGin 7.411 14.137 BLAminus -139.87, 175.04 60.92, 88.41 -94.92, 18.04 278.75, 87.35 -59.01, -34.32 out-in out 10.174 Saltbr-in 2.877 HRD-in -67.48, -51.05 72.2, -5.59 in-in-out SNCiio in-out ActLoopNT-in 3.029 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.52, 150.63 APE9-dihe-na 107.16, 178.8 APE8-dihe-in -62.54, 134.22 APE8-rot-out 175.32 APE67-dihe-in -59.81, -28.17 -63.52, -36.76 APE12-dist-in 7.779 APE11-dist-in 11.439 APE10-dist-in 5.768 APE9-dist-in 4.246 None None None XRAY 2.5 0.183 0.215 A 559 451 0 0 0 0 [[16, 268]] 1.0 8bik Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 8BIKD P54646 9 551 552.0 STU:61001,QTN:61002 Type1,Allosteric Inactive DFGin 7.384 14.445 BLAminus -141.24, 172.63 63.28, 83.56 -89.35, 21.67 278.42, 85.15 -58.54, -35.7 out-in out 10.175 Saltbr-in 2.805 HRD-in -67.72, -52.05 72.56, -5.24 in-in-out SNCiio in-out ActLoopNT-in 3.039 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -138.07, 151.38 APE9-dihe-na 109.6, 178.13 APE8-dihe-in -63.22, 133.31 APE8-rot-out 174.24 APE67-dihe-in -63.88, -27.23 -63.0, -33.55 APE12-dist-in 7.808 APE11-dist-in 11.338 APE10-dist-in 5.694 APE9-dist-in 4.224 None None None XRAY 2.5 0.183 0.215 D 559 443 0 0 0 0 [[16, 268]] 1.0 8bik Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 6B2EA P54646 9 551 552.0 STU:60601,CG7:60602 Type1,Allosteric Inactive DFGin 6.836 14.675 BLAminus -127.75, -179.24 60.25, 73.12 -88.18, 14.06 273.69, 88.23 -67.6, -15.67 out-none out 10.002 Saltbr-none 999.0 HRD-out -78.51, 91.55 -68.49, -19.81 none-in-out SNCnio in-out ActLoopNT-in 3.123 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiio APE10-dihe-na -70.16, 148.6 APE9-dihe-na -63.35, -41.66 APE8-dihe-in -61.85, 118.31 APE8-rot-out 58.89 APE67-dihe-out -81.11, 165.06 -67.04, -35.27 APE12-dist-in 8.467 APE11-dist-in 10.8 APE10-dist-in 6.939 APE9-dist-out 8.497 None TPO172 TPO172 XRAY 3.8 0.246 0.277 A 565 443 0 0 0 0 [[16, 268]] 1.0 6b2e Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFEA P54646 8 551 552.0 STU:61552,992:61553 Type1,Allosteric Inactive DFGin 7.08 14.072 BLAminus -145.68, 179.18 60.7, 83.63 -96.97, 26.73 284.08, 87.71 -65.51, -24.73 out-out out 10.728 Saltbr-out 5.354 HRD-out -86.27, 102.77 -89.89, 0.95 out-in-out SNCoio in-out ActLoopNT-in 3.112 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -129.79, 163.12 APE9-dihe-na 115.46, -178.56 APE8-dihe-in -67.55, 156.43 APE8-rot-out 179.35 APE67-dihe-out -75.24, 179.33 -55.61, -52.75 APE12-dist-in 7.832 APE11-dist-in 11.182 APE10-dist-in 5.502 APE9-dist-in 4.035 None TPO172 TPO172 XRAY 3.023 0.219 0.253 A 571 426 0 0 0 0 [[16, 268]] 1.0 4cfe Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFEC P54646 10 551 552.0 STU:61552,992:61553 Type1,Allosteric Inactive DFGin 6.788 14.041 BLAminus -149.49, 177.86 54.08, 78.43 -74.33, -60.5 283.52, 75.88 44.88, -65.29 out-out out 10.828 Saltbr-out 5.246 HRD-out -83.19, 107.96 -92.05, 0.22 out-in-out SNCoio in-out ActLoopNT-in 2.974 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -138.71, 159.05 APE9-dihe-na 117.28, 177.67 APE8-dihe-in -66.82, 154.33 APE8-rot-out 184.3 APE67-dihe-out -85.99, 172.12 -55.69, -41.12 APE12-dist-in 7.71 APE11-dist-in 11.043 APE10-dist-in 5.418 APE9-dist-in 4.215 None TPO172 TPO172 XRAY 3.023 0.219 0.253 C 571 404 0 0 0 0 [[16, 268]] 1.0 4cfe Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5EZVA P54646 8 551 552.0 STU:60601,C1V:60602 Type1,Allosteric Inactive DFGin 7.267 14.633 None -121.03, -63.06 -68.65, 101.9 -100.19, 25.35 279.34, 91.81 -68.17, -44.69 in-in in 9.861 Saltbr-in 2.69 HRD-in -59.46, -47.11 63.8, -4.14 in-in-in SNCiii in-in ActLoopNT-in 3.003 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.63, 144.51 APE9-dihe-na 86.66, 177.12 APE8-dihe-in -64.88, 140.75 APE8-rot-in 312.82 APE67-dihe-in -66.61, -22.38 -58.4, -32.39 APE12-dist-in 7.754 APE11-dist-in 10.437 APE10-dist-in 5.131 APE9-dist-in 4.403 None TPO172 TPO172 XRAY 2.99 0.225 0.245 A 560 424 0 0 0 0 [[16, 268]] 1.0 5ezv Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 5EZVC P54646 9 551 552.0 STU:60601,C1V:60602 Type1,Allosteric Inactive DFGin 7.432 14.349 None -121.9, -67.2 -69.32, 103.91 -104.03, 30.29 280.2, 90.51 -70.5, -44.85 out-in out 10.415 Saltbr-in 3.208 HRD-in -65.9, -50.28 64.78, -4.1 in-in-out SNCiio in-out ActLoopNT-in 2.939 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.83, 151.12 APE9-dihe-na 88.46, 177.26 APE8-dihe-in -64.21, 140.09 APE8-rot-out 194.68 APE67-dihe-in -65.12, -32.21 -57.93, -31.87 APE12-dist-in 7.836 APE11-dist-in 10.536 APE10-dist-in 5.113 APE9-dist-in 4.486 None TPO172 TPO172 XRAY 2.99 0.225 0.245 C 560 426 0 0 0 0 [[16, 268]] 1.0 5ezv Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 6B1UA P54646 8 550 552.0 STU:60601,CG7:60602 Type1,Allosteric Inactive DFGin 7.269 14.441 None -129.47, -55.38 -79.75, 100.47 -94.16, 25.18 281.88, 87.91 -69.36, -38.1 out-in out 10.09 Saltbr-in 2.806 HRD-in -70.7, -48.35 62.09, 8.12 in-in-out SNCiio in-out ActLoopNT-in 3.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -119.71, 141.45 APE9-dihe-na 98.59, 173.56 APE8-dihe-in -72.38, 142.58 APE8-rot-out 181.03 APE67-dihe-in -62.9, -27.33 -58.67, -32.16 APE12-dist-in 7.972 APE11-dist-in 10.522 APE10-dist-in 4.976 APE9-dist-in 3.876 None TPO172 TPO172 XRAY 2.77 0.196 0.226 A 565 442 0 0 0 0 [[16, 268]] 1.0 6b1u Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKAA2 AAPK2_HUMAN 4CFFC P54646 10 551 552.0 STU:61552,C1V:61553 Type1,Allosteric Inactive DFGin 6.781 14.08 None -150.62, -172.52 53.67, 68.27 -65.24, -76.3 281.99, 78.69 54.48, -69.27 out-out out 10.896 Saltbr-out 5.309 HRD-out -84.81, 105.73 -92.0, 12.06 out-in-out SNCoio in-out ActLoopNT-in 3.034 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -122.19, 170.3 APE9-dihe-na 112.32, 178.27 APE8-dihe-in -67.95, 156.54 APE8-rot-out 180.36 APE67-dihe-out -82.42, 177.62 -55.27, -42.84 APE12-dist-in 7.754 APE11-dist-in 11.137 APE10-dist-in 5.433 APE9-dist-in 3.967 None TPO172 TPO172 XRAY 3.924 0.211 0.264 C 571 423 0 0 0 0 [[16, 268]] 1.0 4cff Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CMGC CDK2 CDK2_HUMAN 4ERWA P24941 1 298 298.0 STU:301 Type1 Inactive DFGin 8.162 15.602 BLBminus -125.29, 160.66 52.47, 61.82 -60.63, 138.56 279.12, 65.63 -74.82, 135.35 out-out out 15.467 Saltbr-out 12.024 HRD-in -85.09, -48.23 77.57, -22.2 out-out-out SNCooo out-out ActLoopNT-out 9.279 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -82.87, 148.53 APE9-dihe-na -96.15, 140.05 APE8-dihe-in -88.42, 131.99 APE8-rot-out 198.97 APE67-dihe-in -59.72, -24.59 -102.21, -6.98 APE12-dist-out 19.529 APE11-dist-out 16.258 APE10-dist-out 18.687 APE9-dist-out 10.897 None None OCS177 XRAY 2.0 0.196 0.244 A 306 293 5 0 0 0 [[4, 286]] 1.0 4erw Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EZ7A P24941 1 298 298.0 STU:60301,2AN:60302,2AN:60303 Type1,Type3,Allosteric Inactive DFGin 6.978 14.625 BLBminus -145.53, 170.39 52.9, 57.73 -61.57, 149.9 287.28, 68.06 -86.96, 168.33 out-out out 16.748 Saltbr-out 14.413 HRD-in -86.07, -42.21 71.45, -15.9 out-out-out SNCooo out-out ActLoopNT-out 10.236 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -63.47, 156.15 APE9-dihe-na -125.23, 14.23 APE8-dihe-out -63.17, -28.79 APE8-rot-in 293.42 APE67-dihe-in -53.71, -31.99 -57.23, -35.61 APE12-dist-out 18.472 APE11-dist-out 18.425 APE10-dist-out 13.977 APE9-dist-out 11.306 None None None XRAY 2.49 0.22 0.274 A 306 298 0 0 0 0 [[4, 286]] 1.0 4ez7 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1AQ1A P24941 1 298 298.0 STU:299 Type1 Inactive DFGin 7.283 14.934 BLBplus -138.32, 166.15 50.99, 60.93 -140.99, 149.68 67.4, 106.52 86.86, 1.1 out-out out 14.888 Saltbr-out 13.171 HRD-in -84.88, -53.74 82.51, -14.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -59.57, 119.45 APE9-dihe-na -86.87, 141.05 APE8-dihe-in -59.86, 138.54 APE8-rot-out 207.57 APE67-dihe-in -54.1, -30.89 -108.21, -4.5 APE12-dist-none 999.0 APE11-dist-out 16.32 APE10-dist-out 19.124 APE9-dist-out 10.677 None None None XRAY 2.0 0.22 0.26 A 298 277 21 0 0 13 [[4, 286]] 1.0 1aq1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7NVQA P24941 1 294 298.0 STU:301 Type1 Inactive DFGin 7.026 14.701 BLBplus -138.98, 166.91 60.92, 69.03 -161.06, 162.59 72.07, 108.19 128.48, -14.92 out-out out 14.351 Saltbr-out 15.166 HRD-in -80.38, -55.15 83.91, -13.55 out-out-out SNCooo out-out ActLoopNT-out 6.029 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.14, 127.57 APE9-dihe-na -77.4, 113.59 APE8-dihe-in -55.3, 141.9 APE8-rot-out 195.1 APE67-dihe-in -55.26, -27.26 -100.43, -4.92 APE12-dist-out 18.864 APE11-dist-out 17.703 APE10-dist-out 18.976 APE9-dist-out 9.89 None None None XRAY 2.05 0.24 0.288 A 300 287 7 0 0 0 [[4, 286]] 1.0 7nvq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC GSK3B GSK3B_HUMAN 1Q3DA P49841 35 385 420.0 STU:451 Type1 Active DFGin 7.206 14.411 BLAminus -139.48, 178.33 63.94, 87.17 -99.43, 23.77 282.58, 69.4 -66.25, -14.58 in-in in 8.701 Saltbr-in 2.855 HRD-in -65.74, -44.7 66.01, 11.52 in-in-in SNCiii in-in ActLoopNT-in 3.036 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -94.53, 169.72 APE9-dihe-na 81.56, 143.56 APE8-dihe-in -91.54, 154.32 APE8-rot-in 294.67 APE67-dihe-inflip 96.36, -28.56 -51.12, 132.48 APE12-dist-in 13.074 APE11-dist-in 11.108 APE10-dist-in 6.087 APE9-dist-in 3.274 None None None XRAY 2.2 0.23 0.252 A 424 339 12 0 0 0 [[56, 340]] 1.0 1q3d Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1Q3DB P49841 35 383 420.0 STU:452 Type1 Active DFGin 7.26 14.419 BLAminus -137.95, 177.39 64.41, 87.07 -97.99, 22.53 282.7, 70.11 -63.96, -17.29 in-in in 8.708 Saltbr-in 2.972 HRD-in -67.72, -45.35 66.86, 12.1 in-in-in SNCiii in-in ActLoopNT-in 3.024 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -93.75, 170.28 APE9-dihe-na 79.08, 144.81 APE8-dihe-in -89.94, 151.95 APE8-rot-in 299.26 APE67-dihe-inflip 101.61, -31.22 -54.51, 132.99 APE12-dist-in 13.085 APE11-dist-in 11.088 APE10-dist-in 6.146 APE9-dist-in 3.238 None None None XRAY 2.2 0.23 0.252 B 424 339 10 0 0 0 [[56, 340]] 1.0 1q3d Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
OTHER ERN1 ERN1_HUMAN 4YZCA O75460 562 963 977.0 STU:1001 Type1 None DFGin 4.54 13.598 BLAminus -149.66, -173.45 57.49, 66.53 -77.65, -2.16 287.89, 65.87 -48.01, -38.7 in-none in 9.363 Saltbr-none 999.0 HRD-in -69.99, -44.37 70.23, -12.54 none-in-in SNCnii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -68.95, 160.8 APE9-dihe-na 106.7, 168.85 APE8-dihe-in -105.56, 142.33 APE8-rot-in 309.63 APE67-dihe-inflip 90.78, -21.58 -55.3, 131.97 APE12-dist-in 10.401 APE11-dist-in 11.328 APE10-dist-in 5.406 APE9-dist-in 3.601 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.494 0.249 0.289 A 405 385 17 0 0 1 [[571, 832]] 1.0 4yzc Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZCB O75460 562 963 977.0 STU:1001 Type1 None DFGin 4.362 13.613 BLAminus -140.88, -173.22 59.3, 72.64 -84.99, 5.45 286.37, 62.28 -53.44, -38.69 in-none in 9.608 Saltbr-none 999.0 HRD-in -70.83, -44.64 74.46, -16.49 none-in-in SNCnii in-in ActLoopNT-in 2.971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -78.48, 164.52 APE9-dihe-na 106.87, 177.31 APE8-dihe-in -111.04, 139.81 APE8-rot-in 310.36 APE67-dihe-inflip 90.66, -20.76 -52.98, 131.15 APE12-dist-in 10.836 APE11-dist-in 11.233 APE10-dist-in 5.394 APE9-dist-in 3.693 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.494 0.249 0.289 B 405 384 18 0 0 2 [[571, 832]] 1.0 4yzc Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER STK16 STK16_HUMAN 2BUJA O75716 13 299 305.0 STU:61301,STU:61302 Type1,Allosteric Active DFGin 5.288 13.003 BLAminus -135.89, -178.46 61.93, 77.23 -105.11, 26.12 316.44, 178.21 -83.9, 1.31 in-in in 9.024 Saltbr-in 2.989 HRD-in -74.11, -51.49 80.14, -8.2 in-in-in SNCiii in-in ActLoopNT-in 2.971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.51, -7.91 APE9-dihe-na -119.57, 103.56 APE8-dihe-in -42.23, 126.34 APE8-rot-in 303.64 APE67-dihe-in -75.83, -5.68 -58.31, -41.55 APE12-dist-in 12.919 APE11-dist-in 9.177 APE10-dist-in 4.941 APE9-dist-in 4.0 R19H,R266W None None XRAY 2.6 0.187 0.229 A 317 283 4 0 0 0 [[20, 292]] 1.0 2buj Homo sapiens OTHER_STK16_HUMAN OTHER 4.7e-40 143.7 1 258 258 165 166 167 169 171 49 65 69 145 147 146 148 217 202 197 196 195 194 193 192 191 99 Serine/threonine-protein kinase 16
OTHER STK16 STK16_HUMAN 2BUJB O75716 13 297 305.0 STU:61299,STU:61300 Type1,Type1 Active DFGin 5.474 13.493 BLAminus -129.22, -175.67 64.04, 67.15 -107.31, -12.83 320.05, 164.52 -59.54, -39.15 in-in in 8.947 Saltbr-in 2.374 HRD-in -61.68, -60.28 75.79, -4.77 in-in-in SNCiii in-in ActLoopNT-in 3.197 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.51, -36.93 APE9-dihe-na -101.29, 104.25 APE8-dihe-in -41.65, 126.41 APE8-rot-in 314.22 APE67-dihe-in -74.19, -9.63 -59.55, -34.23 APE12-dist-in 13.948 APE11-dist-in 10.185 APE10-dist-in 6.538 APE9-dist-in 3.697 R19H,R266W None None XRAY 2.6 0.187 0.229 B 317 277 8 0 0 0 [[20, 292]] 1.0 2buj Homo sapiens OTHER_STK16_HUMAN OTHER 4.7e-40 143.7 1 258 258 165 166 167 169 171 49 65 69 145 147 146 148 217 202 197 196 195 194 193 192 191 99 Serine/threonine-protein kinase 16
OTHER TTK TTK_HUMAN 3HMOA P33981 514 794 857.0 STU:1 Type1 Inactive DFGin 4.034 15.278 ABAminus -96.9, -14.35 -154.28, 164.59 -116.14, 11.51 302.21, 156.99 70.91, 11.96 out-out out 11.148 Saltbr-out 6.638 HRD-in -61.3, -53.03 75.35, 1.42 out-out-out SNCooo out-out ActLoopNT-out 11.68 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -169.39 APE9-dihe-na 94.05, 108.89 APE8-dihe-in -96.62, 156.5 APE8-rot-out 54.19 APE67-dihe-in -64.02, -25.79 -101.71, 14.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.123 APE9-dist-out 11.563 None None None XRAY 2.4 0.217 0.261 A 342 257 24 0 0 12 [[525, 791]] 1.0 3hmo Homo sapiens OTHER_TTK_HUMAN CAMK 1.1e-53 188.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
STE MAP2K6 MP2K6_HUMAN 3FMEA P52564 47 333 334.0 STU:60001 Type1 Inactive None 999.0 999.0 None -108.01, 128.57 -82.08, 37.27 -74.9, 999.0 999.0, 999.0 999.0, 999.0 na-na na 16.092 Saltbr-na 15.231 HRD-in -57.54, -47.19 80.18, -0.06 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_nnno APE10-dihe-na 999.0, 108.95 APE9-dihe-na -76.08, 66.3 APE8-dihe-in -91.33, 156.42 APE8-rot-na 298.81 APE67-dihe-out -82.0, 103.94 -93.42, 147.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 16.976 S207D,T211D None None XRAY 2.26 0.213 0.236 A 290 267 20 0 0 15 [[53, 314]] 1.0 3fme Homo sapiens STE_MAP2K6_HUMAN STE 3.8e-85 291.3 3 257 255 196 197 198 200 202 82 99 103 176 178 177 179 239 223 218 217 216 215 214 213 212 130 Dual specificity mitogen-activated protein kinase kinase 6
STE MAP3K5 M3K5_HUMAN 4BF2A Q99683 671 939 1374.0 STU:1940 Type1 Inactive DFGin 7.213 13.807 BLAminus -114.3, -178.78 51.44, 86.67 -90.54, 15.85 294.66, 96.8 -75.78, -2.2 out-none out 10.049 Saltbr-none 999.0 HRD-in -67.79, -49.78 78.33, -4.9 none-in-out SNCnio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -128.2, 134.23 APE9-dihe-na -68.74, -169.24 APE8-dihe-in -70.38, 133.03 APE8-rot-in 304.95 APE67-dihe-in -66.2, -12.84 -50.6, -52.99 APE12-dist-in 11.059 APE11-dist-out 5.44 APE10-dist-out 9.736 APE9-dist-in 3.512 T838E None None XRAY 2.11 0.208 0.247 A 334 253 16 0 0 6 [[678, 938]] 1.0 4bf2 Homo sapiens STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 4BF2B Q99683 671 940 1374.0 STU:1941 Type1 Inactive DFGin 6.92 13.803 BLAminus -128.63, -177.63 56.0, 77.77 -86.85, 11.45 292.4, 104.75 -69.02, -19.49 in-none in 9.74 Saltbr-none 999.0 HRD-in -67.52, -45.29 72.76, -9.25 none-in-out SNCnio in-out ActLoopNT-in 3.012 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 145.57 APE9-dihe-na -77.44, -148.98 APE8-dihe-in -83.86, 130.43 APE8-rot-in 307.99 APE67-dihe-in -59.87, -30.7 -43.72, -58.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.696 APE9-dist-in 3.527 T838E None None XRAY 2.11 0.208 0.247 B 334 252 18 0 0 9 [[678, 938]] 1.0 4bf2 Homo sapiens STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 2CLQA Q99683 670 940 1374.0 STU:1941 Type1 Inactive DFGinter 5.918 8.469 BABtrans -91.39, 129.8 -141.56, 7.65 -79.81, 110.16 226.87, 94.37 134.88, -46.11 out-out out 10.127 Saltbr-out 4.796 HRD-in -81.27, -49.85 78.55, 0.8 out-in-out SNCoio in-out ActLoopNT-in 3.025 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -136.64, 134.41 APE9-dihe-na -79.2, -159.26 APE8-dihe-in -79.76, 137.19 APE8-rot-in 323.06 APE67-dihe-in -73.67, -16.9 -62.96, -40.27 APE12-dist-in 11.61 APE11-dist-out 6.223 APE10-dist-out 10.04 APE9-dist-in 3.702 None None None XRAY 2.3 0.204 0.257 A 295 263 8 0 0 5 [[678, 938]] 1.0 2clq Homo sapiens STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 2CLQB Q99683 670 940 1374.0 STU:1941 Type1 Inactive DFGinter 6.564 8.021 BABtrans -97.55, 126.7 -140.68, 10.18 -79.54, 109.54 215.05, 109.45 130.73, -46.4 in-none in 9.98 Saltbr-none 999.0 HRD-in -83.48, -49.36 79.39, -1.77 none-in-out SNCnio in-out ActLoopNT-in 3.001 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -136.24, 136.94 APE9-dihe-na -82.54, -165.1 APE8-dihe-in -71.26, 138.19 APE8-rot-in 313.5 APE67-dihe-in -70.89, -23.23 -61.89, -43.74 APE12-dist-none 999.0 APE11-dist-out 6.267 APE10-dist-out 10.013 APE9-dist-in 3.749 None None None XRAY 2.3 0.204 0.257 B 295 259 12 0 0 8 [[678, 938]] 1.0 2clq Homo sapiens STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE PAK4 PAK4_HUMAN 5VEDA O96013 300 589 591.0 STU:601 Type1 Inactive DFGin 7.591 14.871 BLAminus -137.67, -169.84 57.61, 74.14 -100.29, 38.24 286.21, 78.54 -72.3, -31.74 in-out in 8.771 Saltbr-out 5.279 HRD-in -70.67, -47.26 60.82, 22.3 out-in-in SNCoii in-in ActLoopNT-in 2.978 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.74, 169.93 APE9-dihe-na 110.0, -167.24 APE8-dihe-in -107.4, 122.99 APE8-rot-in 313.49 APE67-dihe-in -72.02, -18.93 -37.81, -47.81 APE12-dist-in 8.493 APE11-dist-in 11.13 APE10-dist-in 5.271 APE9-dist-in 3.412 None SEP474 SEP474 XRAY 2.301 0.231 0.277 A 319 290 0 0 0 0 [[321, 572]] 1.0 5ved Homo sapiens STE_PAK4_HUMAN STE 2.4e-88 301.8 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE STK24 STK24_HUMAN 3CKXA Q9Y6E0 32 310 443.0 STU:60305 Type1 Inactive DFGin 6.554 14.149 BLAminus -132.73, 176.63 58.71, 84.09 -98.54, 27.24 290.72, 79.22 -58.51, -31.96 in-out in 8.018 Saltbr-out 4.137 HRD-in -69.03, -39.23 63.51, 16.34 out-in-in SNCoii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.66, 153.77 APE9-dihe-na 128.68, -169.17 APE8-dihe-in -106.02, 124.24 APE8-rot-in 327.58 APE67-dihe-in -59.9, -29.27 -40.36, -54.25 APE12-dist-in 8.432 APE11-dist-in 11.065 APE10-dist-in 5.473 APE9-dist-in 3.366 None TPO190 TPO190 XRAY 2.7 0.204 0.268 A 304 277 2 0 0 0 [[36, 286]] 1.0 3ckx Homo sapiens STE_STK24_HUMAN STE 3.6e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4QMYA Q9Y6E0 20 310 443.0 STU:60401 Type1 Active DFGin 6.746 14.586 BLAminus -133.42, 171.19 64.86, 84.46 -97.43, 25.83 286.76, 75.76 -58.45, -26.25 in-in in 8.74 Saltbr-in 3.092 HRD-in -71.07, -50.71 71.45, 2.06 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.42, 163.67 APE9-dihe-na 122.07, -169.11 APE8-dihe-in -113.85, 118.11 APE8-rot-in 305.93 APE67-dihe-in -57.67, -29.25 -41.23, -48.77 APE12-dist-in 8.319 APE11-dist-in 10.932 APE10-dist-in 5.108 APE9-dist-in 3.246 None TPO190 TPO190 XRAY 1.883 0.18 0.22 A 310 288 0 0 0 0 [[36, 286]] 1.0 4qmy Homo sapiens STE_STK24_HUMAN STE 3.9e-100 340.4 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
TKL IRAK4 IRAK4_HUMAN 2OICA Q9NWZ3 163 458 460.0 STU:1 Type1 Active DFGin 7.542 14.55 BLAminus -120.17, -157.79 43.1, 78.64 -95.77, 16.12 291.84, 81.73 -52.42, -46.68 in-in in 9.164 Saltbr-in 2.745 HRD-in -70.7, -51.8 81.1, -5.15 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.11, 162.72 APE9-dihe-na 127.09, -176.82 APE8-dihe-in -109.75, 123.25 APE8-rot-in 303.17 APE67-dihe-in -63.31, -16.61 -48.06, -48.45 APE12-dist-in 10.133 APE11-dist-in 11.724 APE10-dist-in 6.347 APE9-dist-in 3.446 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 A 301 279 17 0 0 6 [[183, 456]] 1.0 2oic Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICB Q9NWZ3 164 459 460.0 STU:2 Type1 Active DFGin 7.301 14.318 BLAminus -135.72, -165.01 43.24, 86.39 -100.56, 27.64 301.91, 89.45 -68.65, -40.8 in-in in 8.997 Saltbr-in 3.022 HRD-in -70.79, -51.12 80.52, -12.66 in-in-in SNCiii in-in ActLoopNT-in 2.849 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.84, 167.54 APE9-dihe-na 125.4, -168.64 APE8-dihe-in -121.45, 120.26 APE8-rot-in 302.84 APE67-dihe-in -66.81, -13.26 -49.44, -48.37 APE12-dist-in 10.093 APE11-dist-in 11.718 APE10-dist-in 6.031 APE9-dist-in 3.687 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 B 301 278 18 0 0 6 [[183, 456]] 1.0 2oic Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICC Q9NWZ3 161 458 460.0 STU:3 Type1 None DFGin 7.642 14.512 BLAminus -134.38, -175.33 55.45, 88.83 -103.9, 2.57 299.42, 100.27 -42.77, 999.0 in-in in 9.176 Saltbr-in 3.297 HRD-in -70.98, -49.49 84.28, -16.44 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -109.35, 145.04 APE9-dihe-na 142.04, -179.34 APE8-dihe-in -123.52, 118.39 APE8-rot-in 307.07 APE67-dihe-in -69.67, -21.31 -65.38, -24.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.567 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 C 301 280 18 0 0 10 [[183, 456]] 1.0 2oic Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICD Q9NWZ3 161 459 460.0 STU:4 Type1 Active DFGin 6.964 14.795 BLAminus -128.12, -176.74 47.11, 78.66 -89.74, 11.31 298.87, 93.52 -54.67, -36.62 in-in in 8.701 Saltbr-in 2.614 HRD-in -65.25, -53.17 80.56, 0.44 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.06, 151.9 APE9-dihe-na 143.33, 177.59 APE8-dihe-in -104.02, 127.84 APE8-rot-in 302.2 APE67-dihe-in -61.5, -18.42 -54.54, -50.36 APE12-dist-in 10.572 APE11-dist-in 11.674 APE10-dist-in 6.11 APE9-dist-in 3.484 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 D 301 287 12 0 0 2 [[183, 456]] 1.0 2oic Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRYC Q9NWZ3 164 458 460.0 STU:503 Type1 Active DFGin 7.396 13.991 BLAminus -129.87, 177.33 66.53, 79.75 -106.36, 3.08 302.75, 99.86 -41.96, -44.4 in-in in 9.05 Saltbr-in 2.876 HRD-in -69.99, -46.9 74.7, -3.92 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.06, 166.37 APE9-dihe-na 122.8, -162.09 APE8-dihe-in -122.72, 120.05 APE8-rot-in 297.38 APE67-dihe-in -61.23, -20.14 -50.62, -47.6 APE12-dist-in 11.845 APE11-dist-in 12.224 APE10-dist-in 7.0 APE9-dist-in 3.864 None TPO345 TPO345 XRAY 2.15 0.212 0.261 C 307 281 14 0 0 4 [[183, 456]] 1.0 2nry Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRYD Q9NWZ3 164 460 460.0 STU:501 Type1 Active DFGin 7.103 14.601 BLAminus -126.69, 167.35 70.82, 64.69 -93.05, 43.05 345.42, 126.85 -89.85, -18.2 in-in in 9.176 Saltbr-in 2.95 HRD-in -59.6, -55.9 83.92, -5.49 in-in-in SNCiii in-in ActLoopNT-in 2.724 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.15, 176.95 APE9-dihe-na 112.24, -167.34 APE8-dihe-in -128.61, 119.15 APE8-rot-in 302.8 APE67-dihe-in -66.3, -17.75 -48.9, -47.71 APE12-dist-in 10.025 APE11-dist-in 11.615 APE10-dist-in 6.271 APE9-dist-in 3.538 None TPO345 TPO345 XRAY 2.15 0.212 0.261 D 307 283 14 0 0 5 [[183, 456]] 1.0 2nry Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U97A Q9NWZ3 166 458 460.0 STU:501 Type1 None DFGin 7.218 14.495 BLAminus -133.4, -177.52 44.45, 65.76 -75.86, 30.58 295.34, 78.33 -61.24, -17.68 in-in in 9.111 Saltbr-in 2.796 HRD-in -81.28, -51.43 74.22, 0.69 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.32, 150.98 APE9-dihe-na 154.49, -177.45 APE8-dihe-in -96.07, 115.4 APE8-rot-in 303.66 APE67-dihe-in -67.54, -17.85 -61.65, -28.02 APE12-dist-in 9.909 APE11-dist-in 11.839 APE10-dist-in 7.032 APE9-dist-in 3.824 D311N None None XRAY 2.65 0.206 0.251 A 312 272 21 0 0 8 [[183, 456]] 1.0 4u97 Homo sapiens TKL_IRAK4_HUMAN TKL 3e-83 285.4 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U9AA Q9NWZ3 166 458 460.0 STU:501 Type1 None DFGin 7.045 14.907 BLAminus -101.08, -157.39 29.3, 88.18 -95.05, 25.51 282.71, 82.79 -64.14, 4.87 in-in in 8.998 Saltbr-in 3.226 HRD-in -68.43, -44.05 62.5, 13.64 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.36, 146.03 APE9-dihe-na 162.68, -156.1 APE8-dihe-in -121.4, 112.37 APE8-rot-in 316.45 APE67-dihe-in -59.48, -18.83 -58.3, -38.15 APE12-dist-in 9.983 APE11-dist-in 11.951 APE10-dist-in 7.219 APE9-dist-in 3.878 D311N None None XRAY 2.8 0.185 0.24 A 312 272 21 0 0 8 [[183, 456]] 1.0 4u9a Homo sapiens TKL_IRAK4_HUMAN TKL 3e-83 285.4 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRYA Q9NWZ3 164 458 460.0 STU:504 Type1 Inactive DFGin 7.039 13.85 BLBminus -119.68, 177.11 59.06, 71.69 -112.23, -126.05 350.98, 70.79 78.1, -70.69 in-in in 9.03 Saltbr-in 2.758 HRD-in -65.27, -50.09 77.33, -7.45 in-in-in SNCiii in-in ActLoopNT-in 2.754 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.61, 161.22 APE9-dihe-na 128.42, -175.43 APE8-dihe-in -120.1, 117.97 APE8-rot-in 299.02 APE67-dihe-in -57.48, -21.15 -43.86, -55.05 APE12-dist-in 10.988 APE11-dist-in 13.053 APE10-dist-in 7.67 APE9-dist-in 3.682 None TPO345 TPO345 XRAY 2.15 0.212 0.261 A 307 287 8 0 0 5 [[183, 456]] 1.0 2nry Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRYB Q9NWZ3 164 458 460.0 STU:502 Type1 Inactive DFGin 7.33 14.211 BLBminus -121.91, 179.32 63.59, 83.43 -104.91, -160.11 313.36, 100.13 93.41, -69.05 in-out in 8.992 Saltbr-out 3.775 HRD-in -74.38, -53.26 85.42, -10.52 out-in-in SNCoii in-in ActLoopNT-in 2.61 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.77, 162.03 APE9-dihe-na 124.37, -168.49 APE8-dihe-in -121.78, 111.1 APE8-rot-in 307.1 APE67-dihe-in -48.86, -28.56 -36.36, -56.5 APE12-dist-in 9.932 APE11-dist-in 12.138 APE10-dist-in 6.485 APE9-dist-in 3.62 None TPO345 TPO345 XRAY 2.15 0.212 0.261 B 307 287 8 0 0 5 [[183, 456]] 1.0 2nry Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U97B Q9NWZ3 166 458 460.0 STU:501 Type1 Inactive DFGin 5.294 14.217 None -136.34, -175.59 46.99, 62.58 -120.73, 999.0 61.34, 86.78 999.0, 999.0 in-in in 9.393 Saltbr-in 2.996 HRD-in -71.9, -50.3 83.45, -13.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -128.91, -19.36 APE9-dihe-na -55.91, 145.79 APE8-dihe-in -64.15, 91.3 APE8-rot-in 291.9 APE67-dihe-in -57.49, -34.64 -51.29, -30.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.145 D311N None None XRAY 2.65 0.206 0.251 B 312 270 23 0 0 12 [[183, 456]] 1.0 4u97 Homo sapiens TKL_IRAK4_HUMAN TKL 3e-83 285.4 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U9AB Q9NWZ3 166 458 460.0 STU:501 Type1 Inactive DFGin 5.633 14.406 None -136.0, 173.79 77.97, 80.6 -165.88, 999.0 67.94, 103.04 999.0, 999.0 in-in in 9.402 Saltbr-in 2.924 HRD-in -69.54, -47.75 75.57, 5.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -138.84, -18.64 APE9-dihe-na -63.49, 153.65 APE8-dihe-in -64.27, 92.38 APE8-rot-in 304.32 APE67-dihe-in -63.41, -26.11 -54.68, -17.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.359 D311N None None XRAY 2.8 0.185 0.24 B 312 270 23 0 0 12 [[183, 456]] 1.0 4u9a Homo sapiens TKL_IRAK4_HUMAN TKL 3e-83 285.4 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL LIMK1 LIMK1_HUMAN 3S95A P53667 330 637 647.0 STU:60001 Type1 Active DFGin 6.504 14.072 BLAminus -132.12, 176.01 61.94, 79.29 -96.74, 17.56 299.36, 104.43 -67.12, -24.68 in-in in 7.478 Saltbr-in 2.77 HRD-in -69.3, -54.34 71.96, -1.22 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -137.33, 152.92 APE9-dihe-na 118.99, 175.51 APE8-dihe-in -76.56, 127.6 APE8-rot-na 188.61 APE67-dihe-in -66.82, -23.07 -64.42, -23.72 APE12-dist-in 9.219 APE11-dist-in 11.444 APE10-dist-in 5.645 APE9-dist-in 3.746 None None None XRAY 1.65 0.157 0.181 A 310 288 20 0 0 20 [[339, 606]] 1.0 3s95 Homo sapiens TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3 266 264 477 478 479 481 483 368 384 388 457 459 458 460 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 3S95B P53667 330 637 647.0 STU:60001 Type1 Active DFGin 6.465 13.723 BLAminus -137.18, 172.16 66.04, 80.35 -97.8, 13.37 302.38, 103.91 -61.7, -26.69 in-in in 7.806 Saltbr-in 2.596 HRD-in -67.95, -51.91 71.9, -3.03 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -131.01, 146.52 APE9-dihe-na 126.16, 169.25 APE8-dihe-in -67.25, 124.73 APE8-rot-na 183.11 APE67-dihe-in -72.71, -16.93 -64.76, -21.17 APE12-dist-in 9.115 APE11-dist-in 11.268 APE10-dist-in 5.405 APE9-dist-in 3.783 None None None XRAY 1.65 0.157 0.181 B 310 288 20 0 0 20 [[339, 606]] 1.0 3s95 Homo sapiens TKL_LIMK1_HUMAN TKL 4.5e-77 265.1 3 266 264 477 478 479 481 483 368 384 388 457 459 458 460 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL RIPK2 RIPK2_HUMAN 5NG2A O43353 5 298 540.0 STU:401 Type1 Inactive DFGin 5.959 13.876 BLAminus -127.83, 178.19 61.49, 80.49 -96.67, 24.09 288.33, 78.8 -62.82, -31.8 in-in in 8.091 Saltbr-in 2.902 HRD-in -73.87, -50.37 57.71, 19.44 in-in-out SNCiio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 149.89 APE8-dihe-in -77.86, 146.25 APE8-rot-out 189.94 APE67-dihe-in -66.59, -20.81 -105.1, 1.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.855 D146N None None XRAY 2.8 0.209 0.226 A 304 274 20 0 0 14 [[18, 292]] 1.0 5ng2 Homo sapiens TKL_RIPK2_HUMAN TKL 2.6e-72 249.5 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5NG2B O43353 5 298 540.0 STU:401 Type1 Inactive DFGin 5.987 13.9 BLAminus -127.96, 178.42 61.45, 80.21 -96.5, 23.45 288.92, 78.23 -62.02, -31.71 in-in in 8.093 Saltbr-in 2.894 HRD-in -73.84, -50.5 58.4, 18.77 in-in-out SNCiio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.58 APE8-dihe-in -77.44, 145.88 APE8-rot-out 189.53 APE67-dihe-in -67.7, -20.58 -104.84, 1.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.79 D146N None None XRAY 2.8 0.209 0.226 B 304 278 16 0 0 15 [[18, 292]] 1.0 5ng2 Homo sapiens TKL_RIPK2_HUMAN TKL 2.6e-72 249.5 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL TGFBR1 TGFR1_HUMAN 5E8XA P36897 200 503 503.0 STU:601 Type1 Active DFGin 7.401 13.771 BLAminus -132.02, 177.79 68.95, 84.86 -101.89, 20.89 298.69, 99.78 -60.9, -22.78 in-in in 7.646 Saltbr-in 3.316 HRD-in -78.83, -50.32 78.23, -2.28 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.2, 171.93 APE9-dihe-na 104.3, 177.57 APE8-dihe-in -80.96, 119.4 APE8-rot-in 304.53 APE67-dihe-in -55.33, -34.35 -53.44, -41.29 APE12-dist-in 11.709 APE11-dist-in 11.927 APE10-dist-in 6.258 APE9-dist-in 3.946 T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F None None XRAY 1.45 0.191 0.21 A 307 304 0 0 0 0 [[205, 494]] 1.0 5e8x Homo sapiens TKL_TGFBR1_HUMAN TKL 2.3e-85 292.2 3 266 264 350 351 352 354 356 232 245 249 330 332 331 333 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 5E8WA P36897 200 501 503.0 STU:60601 Type1 Active DFGin 6.216 12.991 BLAminus -115.91, -168.56 48.03, 66.8 -87.81, 6.99 303.66, 6.47 -53.89, -34.67 in-in in 7.561 Saltbr-in 2.815 HRD-in -71.33, -51.46 73.08, -1.55 in-in-in SNCiii in-in ActLoopNT-in 2.992 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -81.36, -32.83 APE9-dihe-na -81.66, -157.24 APE8-dihe-in -82.54, 122.58 APE8-rot-in 299.35 APE67-dihe-in -53.78, -37.25 -53.32, -45.52 APE12-dist-in 13.054 APE11-dist-in 12.418 APE10-dist-in 6.3 APE9-dist-in 3.738 T204D None None XRAY 1.86 0.168 0.186 A 307 302 0 0 0 0 [[205, 494]] 1.0 5e8w Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3 266 264 350 351 352 354 356 232 245 249 330 332 331 333 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR2 TGFR2_HUMAN 5E8YA P37173 240 541 567.0 STU:601 Type1 Inactive DFGin 7.431 13.638 ABAminus -147.57, -29.88 -97.01, 88.29 -98.27, 19.66 300.85, 114.87 -63.28, -27.98 in-in in 7.663 Saltbr-in 2.684 HRD-in -60.19, -53.17 75.99, -7.12 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.67, 141.68 APE9-dihe-na 119.62, -164.78 APE8-dihe-in -99.54, 120.03 APE8-rot-in 310.13 APE67-dihe-in -59.04, -35.21 -51.44, -37.92 APE12-dist-in 11.211 APE11-dist-in 12.073 APE10-dist-in 5.974 APE9-dist-in 4.011 E431A,R433A,E485A,K488A,R493A,R495A None None XRAY 2.05 0.198 0.227 A 316 298 4 0 0 0 [[244, 540]] 1.0 5e8y Homo sapiens TKL_TGFBR2_HUMAN TKL 1.9e-77 266.3 2 266 265 396 397 398 400 402 277 290 294 376 378 377 379 446 428 423 422 421 420 419 418 417 326 TGF-beta receptor type-2
TYR ALK ALK_HUMAN 3LCSA Q9UM73 1096 1399 1620.0 STU:1 Type1 Inactive DFGin 6.33 14.912 ABAminus -115.64, -37.74 -102.74, 114.2 -112.42, 20.01 289.12, 86.66 -56.01, -38.26 in-in in 7.78 Saltbr-in 2.662 HRD-in -69.52, -44.32 78.89, -12.54 in-out-out SNCioo out-out ActLoopNT-out 6.794 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.07, -13.05 APE9-dihe-in -64.04, 139.47 APE8-dihe-in -80.51, 60.39 APE8-rot-na 31.54 APE67-dihe-in -67.01, -14.6 -60.37, -27.86 APE12-dist-na 15.308 APE11-dist-na 15.569 APE10-dist-na 10.539 APE9-dist-out 8.296 S1281G None None XRAY 1.95 0.196 0.229 A 344 304 0 0 0 0 [[1116, 1385]] 1.0 3lcs Homo sapiens TYR_ALK_HUMAN TYR 5e-90 307.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR CSK CSK_HUMAN 3D7TA P41240 188 450 450.0 STU:6335 Type1 Inactive DFGin 4.848 13.727 None -129.86, -75.48 -112.49, 120.17 -68.38, 132.53 310.55, 71.3 -108.94, 999.0 in-in in 9.709 Saltbr-in 3.505 HRD-in -84.81, -41.33 76.65, -6.36 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 92.32 APE8-rot-na 27.67 APE67-dihe-in -57.33, -30.65 -43.31, -55.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K361A,K362A None None XRAY 2.899 0.239 0.278 A 269 249 14 0 0 14 [[195, 442]] 1.0 3d7t Homo sapiens TYR_CSK_HUMAN TYR 5.7e-87 297.2 1 260 260 331 332 333 335 337 222 236 240 311 313 312 314 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
TYR CSK CSK_HUMAN 1BYGA P41240 187 448 450.0 STU:501 Type1 Inactive DFGinter 10.86 7.923 BABtrans -99.17, 153.06 -105.84, -7.01 -68.56, 146.18 156.4, 90.07 -161.79, 133.09 out-out out 14.775 Saltbr-out 12.646 HRD-in -79.54, -44.6 72.05, -5.51 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.52 APE8-dihe-in -71.25, 96.92 APE8-rot-na 16.81 APE67-dihe-in -75.84, -8.12 -42.46, -43.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.292 None None None XRAY 2.4 0.199 0.287 A 278 246 16 0 0 12 [[195, 442]] 1.0 1byg Homo sapiens TYR_CSK_HUMAN TYR 1.2e-87 299.5 1 260 260 331 332 333 335 337 222 236 240 311 313 312 314 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
TYR EPHB4 EPHB4_HUMAN 3ZEWA P54760 609 888 987.0 STU:1889 Type1 None DFGin 6.122 14.359 BLAminus -139.16, 174.72 57.83, 79.91 -97.95, 22.7 299.52, 94.02 -63.4, -45.19 in-in in 8.066 Saltbr-in 2.796 HRD-in -71.2, -51.67 69.26, -8.65 in-in-none SNCiin in-none ActLoopNT-in 2.821 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 56.2 APE9-dihe-in -113.28, 124.67 APE8-dihe-in -75.39, 88.73 APE8-rot-na 23.8 APE67-dihe-in -74.18, -2.68 -39.84, -58.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.292 APE9-dist-in 6.071 None PTR774 PTR774 XRAY 2.5 0.24 0.282 A 298 270 10 0 0 6 [[615, 876]] 1.0 3zew Homo sapiens TYR_EPHB4_HUMAN TYR 2.6e-104 354.1 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 3ZEWB P54760 609 887 987.0 STU:1888 Type1 None DFGin 6.6 14.69 BLAminus -136.46, 179.33 65.25, 57.03 -88.32, 123.85 306.76, 101.31 132.26, 999.0 in-none in 7.638 Saltbr-none 999.0 HRD-in -68.01, -45.09 76.33, -22.89 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.88 APE8-dihe-in -93.06, 95.29 APE8-rot-na 27.85 APE67-dihe-in -68.25, -2.97 -47.06, -56.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.554 None PTR774 PTR774 XRAY 2.5 0.24 0.282 B 298 252 27 0 0 21 [[615, 876]] 1.0 3zew Homo sapiens TYR_EPHB4_HUMAN TYR 2.6e-104 354.1 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2YN8A P54760 608 888 987.0 STU:1889 Type1 Inactive DFGin 6.427 14.617 None -130.9, 178.33 70.32, 85.06 -121.95, 999.0 309.1, 102.44 999.0, 999.0 in-in in 7.533 Saltbr-in 2.751 HRD-in -74.77, -43.96 71.71, -21.91 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.38 APE8-rot-na 24.51 APE67-dihe-in -59.12, -26.62 -41.36, -49.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y774E,A803V,V870I None None XRAY 2.11 0.197 0.234 A 298 253 28 0 0 23 [[615, 876]] 1.0 2yn8 Homo sapiens TYR_EPHB4_HUMAN TYR 4.3e-105 356.6 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 2YN8B P54760 606 888 987.0 STU:1889 Type1 Inactive DFGin 6.429 14.627 None -131.1, 178.0 70.17, 85.21 -120.37, 999.0 309.66, 103.01 999.0, 999.0 in-in in 7.486 Saltbr-in 2.76 HRD-in -75.37, -48.88 76.16, -20.77 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.61 APE8-rot-na 24.46 APE67-dihe-in -59.58, -26.36 -40.69, -50.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y774E,A803V,V870I None None XRAY 2.11 0.197 0.234 B 298 260 23 0 0 23 [[615, 876]] 1.0 2yn8 Homo sapiens TYR_EPHB4_HUMAN TYR 4.3e-105 356.6 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR FES FES_HUMAN 3BKBA P07332 449 821 822.0 STU:826 Type1 Inactive DFGin 6.866 14.424 BLAminus -130.98, -162.57 38.75, 71.71 -85.89, 14.89 281.41, 76.5 -59.73, -36.44 in-in in 6.772 Saltbr-in 2.62 HRD-in -78.26, -50.49 76.66, -9.4 in-in-out SNCiio in-out ActLoopNT-in 2.82 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 47.37, 40.72 APE9-dihe-in -62.75, 132.26 APE8-dihe-in -76.49, 72.71 APE8-rot-na 30.4 APE67-dihe-in -70.68, -13.35 -50.64, -47.62 APE12-dist-na 8.341 APE11-dist-na 11.981 APE10-dist-na 11.225 APE9-dist-in 7.354 None None None XRAY 1.78 0.15 0.189 A 377 373 0 0 0 0 [[561, 816]] 1.0 3bkb Homo sapiens TYR_FES_HUMAN TYR 6.6e-94 320.0 1 260 260 700 701 702 704 706 590 607 611 680 682 681 683 742 730 725 724 723 722 721 720 719 637 Tyrosine-protein kinase Fes/Fps
TYR FES FES_HUMAN 3CBLA P07332 448 821 822.0 STU:60901,STU:60902,STU:60903 Type1,Allosteric,Allosteric Active DFGin 6.992 14.347 BLAminus -129.39, -161.99 36.63, 77.42 -90.17, 19.41 283.19, 78.42 -59.92, -34.07 in-in in 7.018 Saltbr-in 2.618 HRD-in -73.99, -51.91 78.82, -2.64 in-in-in SNCiii in-in ActLoopNT-in 2.742 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.35, 116.24 APE9-dihe-in -118.34, 122.46 APE8-dihe-in -80.03, 88.22 APE8-rot-na 26.81 APE67-dihe-in -66.64, -12.19 -59.28, -46.73 APE12-dist-na 13.862 APE11-dist-na 9.681 APE10-dist-na 8.625 APE9-dist-in 6.867 None None None XRAY 1.75 0.183 0.227 A 377 354 0 0 0 0 [[561, 816]] 1.0 3cbl Homo sapiens TYR_FES_HUMAN TYR 6.6e-94 320.0 1 260 260 700 701 702 704 706 590 607 611 680 682 681 683 742 730 725 724 723 722 721 720 719 637 Tyrosine-protein kinase Fes/Fps
TYR FES FES_HUMAN 3CD3A P07332 448 821 822.0 STU:60901,STU:60902,STU:60903 Type1,Allosteric,Allosteric Active DFGin 7.042 14.319 BLAminus -131.29, -161.96 36.95, 76.94 -87.41, 20.64 283.25, 80.52 -64.77, -30.01 in-in in 6.955 Saltbr-in 2.451 HRD-in -75.66, -48.21 74.09, -7.23 in-in-in SNCiii in-in ActLoopNT-in 2.813 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.76, 114.63 APE9-dihe-in -118.9, 123.98 APE8-dihe-in -79.16, 82.58 APE8-rot-na 23.88 APE67-dihe-in -66.61, -9.96 -49.19, -54.65 APE12-dist-na 14.103 APE11-dist-na 10.043 APE10-dist-na 8.93 APE9-dist-in 7.039 None PTR713 PTR713 XRAY 1.98 0.188 0.247 A 377 351 4 0 0 0 [[561, 816]] 1.0 3cd3 Homo sapiens TYR_FES_HUMAN TYR 6.6e-94 320.0 1 260 260 700 701 702 704 706 590 607 611 680 682 681 683 742 730 725 724 723 722 721 720 719 637 Tyrosine-protein kinase Fes/Fps
TYR FYN FYN_HUMAN 2DQ7X P06241 261 523 537.0 STU:60902 Type1 Active DFGin 6.97 13.853 BLAminus -137.79, 173.21 69.46, 82.83 -98.97, 30.24 286.34, 86.38 -56.5, -37.75 in-in in 7.754 Saltbr-in 2.468 HRD-in -90.12, -49.46 72.41, 2.38 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.8, 126.18 APE9-dihe-in -111.81, 159.77 APE8-dihe-in -55.65, 79.81 APE8-rot-na 29.61 APE67-dihe-in -72.56, -28.8 -30.08, -40.64 APE12-dist-na 13.298 APE11-dist-na 8.679 APE10-dist-na 12.457 APE9-dist-in 6.216 None PTR420 PTR420 XRAY 2.8 0.255 0.281 X 283 263 0 0 0 0 [[271, 522]] 1.0 2dq7 Homo sapiens TYR_FYN_HUMAN TYR 2.6e-94 321.3 1 260 260 407 408 409 411 413 299 314 318 387 389 388 390 448 436 431 430 429 428 427 426 425 343 Tyrosine-protein kinase Fyn
TYR ITK ITK_HUMAN 1SM2A Q08881 357 619 620.0 STU:301 Type1 Inactive DFGin 5.497 13.321 BLBplus -148.18, -157.96 48.2, 18.11 -92.5, -172.62 59.26, 91.5 71.27, 999.0 out-out out 10.504 Saltbr-out 8.01 HRD-out -81.72, 93.89 -66.35, 12.1 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.52 APE8-rot-na 340.44 APE67-dihe-in -77.92, -11.34 -60.73, -6.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.246 0.292 A 264 245 18 0 0 18 [[363, 614]] 1.0 1sm2 Homo sapiens TYR_ITK_HUMAN TYR 9.2e-93 316.2 1 260 260 499 500 501 503 505 391 406 410 479 481 480 482 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SNUA Q08881 357 619 620.0 STU:301 Type1 Inactive DFGin 5.41 13.586 BLBplus -121.03, -147.07 39.99, 19.77 -95.61, 161.03 65.42, 97.15 81.16, 999.0 out-out out 10.985 Saltbr-out 7.73 HRD-out -99.78, 92.32 -72.7, 37.05 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.98 APE8-rot-na 339.02 APE67-dihe-in -71.29, -26.27 -59.31, -15.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.262 0.295 A 264 245 18 0 0 18 [[363, 614]] 1.0 1snu Homo sapiens TYR_ITK_HUMAN TYR 9.2e-93 316.2 1 260 260 499 500 501 503 505 391 406 410 479 481 480 482 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SM2B Q08881 358 617 620.0 STU:621 Type1 Inactive DFGin 5.378 13.379 None -126.46, -161.15 38.96, 42.72 -115.58, 999.0 63.86, 78.79 999.0, 999.0 out-out out 11.099 Saltbr-out 6.805 HRD-out -89.1, 89.71 -64.14, 17.77 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 70.78 APE8-rot-na 24.5 APE67-dihe-in -53.23, -18.63 -53.68, -42.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.246 0.292 B 264 241 19 0 0 19 [[363, 614]] 1.0 1sm2 Homo sapiens TYR_ITK_HUMAN TYR 9.2e-93 316.2 1 260 260 499 500 501 503 505 391 406 410 479 481 480 482 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 1SNUB Q08881 358 617 620.0 STU:621 Type1 Inactive DFGin 5.322 13.361 None -135.24, -161.39 47.41, 33.44 -112.08, 999.0 66.07, 77.87 999.0, 999.0 out-out out 11.118 Saltbr-out 7.484 HRD-out -85.26, 96.7 -69.16, 21.34 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 61.67 APE8-rot-na 31.48 APE67-dihe-in -68.53, -31.16 -49.5, -27.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.262 0.295 B 264 241 19 0 0 19 [[363, 614]] 1.0 1snu Homo sapiens TYR_ITK_HUMAN TYR 9.2e-93 316.2 1 260 260 499 500 501 503 505 391 406 410 479 481 480 482 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR KIT KIT_HUMAN 8S19A P10721 566 931 976.0 STU:61001 Type1 Active DFGin 7.404 13.667 BLAminus -127.12, -176.58 57.62, 86.03 -104.33, 27.64 287.94, 75.89 -65.62, -32.19 in-in in 8.528 Saltbr-in 2.807 HRD-in -86.95, -44.99 76.04, 4.46 in-in-in SNCiii in-in ActLoopNT-in 2.98 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.78, 135.36 APE9-dihe-in -116.81, 146.55 APE8-dihe-in -80.8, 82.76 APE8-rot-na 31.59 APE67-dihe-in -71.09, -10.53 -60.41, -40.84 APE12-dist-na 14.65 APE11-dist-na 10.007 APE10-dist-na 13.468 APE9-dist-in 7.899 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.3 0.186 0.208 A 327 287 1 0 0 1 [[589, 926]] 1.0 8s19 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 8S19B P10721 566 930 976.0 STU:61001 Type1 Active DFGin 7.327 13.538 BLAminus -128.07, -176.35 62.24, 79.08 -101.65, 27.17 286.46, 78.41 -65.78, -31.3 in-in in 8.424 Saltbr-in 3.244 HRD-in -86.63, -46.82 74.21, 3.84 in-in-in SNCiii in-in ActLoopNT-in 2.972 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.88, 148.22 APE9-dihe-in -128.01, 146.9 APE8-dihe-in -81.2, 79.5 APE8-rot-na 31.77 APE67-dihe-in -74.43, -9.18 -60.72, -38.08 APE12-dist-na 14.121 APE11-dist-na 10.132 APE10-dist-na 13.229 APE9-dist-in 7.695 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.3 0.186 0.208 B 327 284 3 0 0 0 [[589, 926]] 1.0 8s19 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR LCK LCK_HUMAN 1QPJA P06239 236 501 509.0 STU:902 Type1 Active DFGin 6.667 13.91 BLAminus -132.46, 174.81 60.31, 82.59 -95.23, 22.99 299.73, 90.17 -64.21, -26.94 in-in in 8.129 Saltbr-in 2.566 HRD-in -98.38, -45.69 71.81, -4.26 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.6, 145.72 APE9-dihe-in -137.74, 152.71 APE8-dihe-in -60.2, 95.29 APE8-rot-na 326.72 APE67-dihe-in -63.01, -25.44 -48.62, -46.8 APE12-dist-na 14.703 APE11-dist-na 10.092 APE10-dist-na 12.948 APE9-dist-in 7.016 None PTR394 PTR394 XRAY 2.2 0.214 0.267 A 279 266 0 0 0 0 [[245, 496]] 1.0 1qpj Homo sapiens TYR_LCK_HUMAN TYR 1.4e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TYR LCK LCK_HUMAN 1QPDA P06239 231 502 509.0 STU:902 Type1 Active DFGin 6.465 14.181 BLAminus -132.18, 176.72 55.71, 84.19 -94.48, 25.19 297.78, 91.73 -59.44, -39.94 in-in in 8.418 Saltbr-in 2.843 HRD-in -101.42, -45.84 73.23, 2.58 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.47, 143.78 APE9-dihe-in -134.7, 155.74 APE8-dihe-in -59.6, 112.24 APE8-rot-na 334.8 APE67-dihe-in -60.08, -21.25 -55.42, -48.02 APE12-dist-na 14.972 APE11-dist-na 10.294 APE10-dist-na 12.967 APE9-dist-in 6.951 None PTR394 PTR394 XRAY 2.0 0.195 0.237 A 279 272 0 0 0 0 [[245, 496]] 1.0 1qpd Homo sapiens TYR_LCK_HUMAN TYR 3.6e-93 317.5 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TYR LYN LYN_HUMAN 3A4OX P07948 238 505 512.0 STU:60902 Type1 Inactive DFGin 6.65 15.581 None -103.69, -177.97 54.14, 148.85 -166.58, 42.86 276.85, 106.11 -75.66, -40.91 in-in in 9.123 Saltbr-in 3.22 HRD-in -82.15, -55.06 93.66, -27.17 in-in-out SNCiio in-out ActLoopNT-in 2.861 ActLoopCT-out TYR APEdihe_ooiai APEdist_aaai APE10-dihe-out -155.78, -36.41 APE9-dihe-out 3.09, -67.88 APE8-dihe-in -48.66, 80.66 APE8-rot-na 28.53 APE67-dihe-in -67.02, 39.44 -53.16, -65.62 APE12-dist-na 7.583 APE11-dist-na 3.398 APE10-dist-na 8.537 APE9-dist-in 6.45 None None None XRAY 3.0 0.293 0.324 X 286 259 9 0 0 9 [[247, 499]] 1.0 3a4o Homo sapiens TYR_LYN_HUMAN TYR 1.2e-95 325.7 1 260 260 384 385 386 388 390 275 290 294 364 366 365 367 425 413 408 407 406 405 404 403 402 320 Tyrosine-protein kinase Lyn
TYR NTRK1 NTRK1_HUMAN 9DAIA P04629 501 796 796.0 STU:801 Type1 Inactive DFGin 7.329 15.102 None -134.39, -155.28 28.01, 68.03 -73.72, 999.0 288.62, 88.06 999.0, 999.0 in-in in 9.698 Saltbr-in 3.253 HRD-in -62.59, -42.57 78.74, -33.91 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.11 APE8-dihe-in -86.91, 69.17 APE8-rot-na 30.89 APE67-dihe-in -62.36, -34.09 -52.62, -31.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.495 None None None XRAY 2.864 0.22 0.277 A 320 264 32 0 0 19 [[510, 783]] 1.0 9dai Homo sapiens TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR SYK KSYK_HUMAN 1XBCA P43405 363 635 635.0 STU:60001 Type1 Active DFGin 6.699 14.236 BLAminus -133.2, -171.25 54.9, 81.04 -97.63, 25.87 287.7, 80.31 -62.67, -30.77 in-in in 8.107 Saltbr-in 2.681 HRD-in -73.91, -54.08 72.64, 5.62 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.93, 102.31 APE9-dihe-in -115.14, 122.86 APE8-dihe-in -77.21, 74.28 APE8-rot-na 27.13 APE67-dihe-in -62.04, -14.77 -51.56, -42.64 APE12-dist-na 10.226 APE11-dist-na 10.661 APE10-dist-na 9.591 APE9-dist-in 6.83 None None None XRAY 2.0 0.246 0.294 A 291 267 6 0 0 0 [[370, 628]] 1.0 1xbc Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR ZAP70 ZAP70_HUMAN 1U59A P43403 328 606 619.0 STU:60100 Type1 Inactive DFGin 6.449 14.655 BLAminus -132.39, 179.54 60.68, 79.94 -93.24, 26.52 286.21, 85.42 -61.36, -30.97 in-in in 8.545 Saltbr-in 2.605 HRD-in -75.34, -52.46 82.3, -36.8 in-in-out SNCiio in-out ActLoopNT-in 2.984 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -109.77, 150.26 APE9-dihe-in -93.67, 137.73 APE8-dihe-in -75.36, 68.87 APE8-rot-na 32.83 APE67-dihe-in -59.55, -7.44 -43.09, -46.01 APE12-dist-na 14.485 APE11-dist-na 13.525 APE10-dist-na 14.7 APE9-dist-out 9.1 None None None XRAY 2.3 0.217 0.271 A 287 276 3 0 0 0 [[338, 595]] 1.0 1u59 Homo sapiens TYR_ZAP70_HUMAN TYR 2.5e-90 308.2 6 259 254 478 479 480 482 484 369 386 390 458 460 459 461 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70
TYR RTKC8 A9VBW0_MONBE 8E4TA A9VBW0 1412 1684 1911.0 STU:61901,STU:61902 Type1,Allosteric Inactive DFGin 5.798 14.258 BLAminus -127.66, 178.05 63.29, 82.89 -96.19, 23.12 289.39, 77.3 -56.36, -33.99 in-in in 8.035 Saltbr-in 2.897 HRD-in -84.2, -48.48 70.19, 15.14 in-in-out SNCiio in-out ActLoopNT-in 2.935 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.95, 2.58 APE9-dihe-in -47.64, 117.94 APE8-dihe-in -73.3, 83.54 APE8-rot-na 25.08 APE67-dihe-in -68.63, -15.26 -57.08, -37.63 APE12-dist-na 12.148 APE11-dist-na 14.573 APE10-dist-na 11.173 APE9-dist-out 8.027 None None None XRAY 1.95 0.206 0.255 A 283 268 5 0 0 5 [[1423, 1678]] 1.0 8e4t Monosiga brevicollis TYR_RTKC8_MONBE TYR 8.9e-85 290.0 3 260 258 1563 1564 1565 1567 1569 1455 1472 1476 1543 1545 1544 1546 1604 1592 1587 1586 1585 1584 1583 1582 1581 1502 non-specific protein-tyrosine kinase
CAMK PRKAA1 AAPK1_MOUSE 5UFUA Q5EG47 20 559 559.0 STU:60601,85V:60602 Type1,Allosteric Inactive DFGin 7.217 14.246 BLAminus -131.5, 162.6 65.85, 93.86 -99.38, 24.57 280.79, 65.36 -57.61, -46.84 in-in in 9.764 Saltbr-in 2.748 HRD-out -69.82, 100.36 -85.07, 166.65 in-in-out SNCiio in-out ActLoopNT-in 2.745 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -90.3, 155.77 APE9-dihe-na 100.05, 157.58 APE8-dihe-in -52.88, 143.31 APE8-rot-out 164.19 APE67-dihe-in -65.21, -41.11 -61.15, -33.48 APE12-dist-in 7.574 APE11-dist-in 11.095 APE10-dist-in 5.13 APE9-dist-out 6.066 None TPO183 TPO183 XRAY 3.45 0.195 0.238 A 503 249 0 0 0 0 [[27, 279]] 1.0 5ufu Mus musculus CAMK_PRKAA1_MOUSE CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
TKL RIPK4 RIPK4_MOUSE 5WNLA Q9ERK0 10 288 786.0 STU:401 Type1 Inactive DFGin 5.357 14.572 BLAminus -134.03, 174.48 63.33, 81.72 -96.92, 21.29 289.3, 76.96 -59.26, -33.93 in-in in 8.778 Saltbr-in 2.733 HRD-in -81.33, -54.8 69.56, 11.14 in-in-out SNCiio in-out ActLoopNT-in 3.066 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 144.67 APE9-dihe-na 85.9, -57.36 APE8-dihe-out -63.74, -13.96 APE8-rot-out 59.65 APE67-dihe-in -59.52, -31.71 -58.84, -41.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.665 APE9-dist-out 11.709 D143N None None XRAY 2.5 0.224 0.256 A 342 262 17 0 0 14 [[19, 285]] 1.0 5wnl Mus musculus TKL_RIPK4_MOUSE TKL 1.4e-74 257.0 4 266 263 160 161 162 164 166 51 69 73 140 142 141 143 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4
CAMK CDPK2 CDPK2_PLAFK 4MVFA O15865 60 511 513.0 STU:60601 Type1 Inactive DFGin 6.815 14.431 ABAminus -113.07, -2.16 -142.08, 130.21 -125.4, 28.29 288.94, 85.92 -61.14, -23.54 in-in in 9.439 Saltbr-in 2.78 HRD-in -82.17, -47.76 70.19, 0.74 in-in-none SNCiin in-none ActLoopNT-in 2.894 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.195 0.23 A 506 405 39 0 0 19 [[72, 326]] 1.0 4mvf Plasmodium falciparum CAMK_CDPK2_PLAFK CAMK 7.5e-88 300.5 1 256 256 212 213 214 216 218 101 117 121 189 191 190 192 250 239 234 233 232 231 230 229 228 147 Calcium-dependent protein kinase 2
CAMK PRKAA1 AAPK1_RAT 6E4TA P54645 20 559 559.0 HTV:60601,STU:60602 Allosteric,Type1 Inactive DFGin 7.435 14.261 ABAminus -127.14, -39.21 -103.64, 92.84 -85.31, 24.03 289.4, 72.26 -73.07, -34.04 out-in out 10.019 Saltbr-in 3.148 HRD-out -67.59, 99.51 -83.8, 164.42 in-in-out SNCiio in-out ActLoopNT-in 2.868 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -86.15, 147.86 APE9-dihe-na 86.15, 170.33 APE8-dihe-in -53.88, 128.36 APE8-rot-out 178.71 APE67-dihe-in -78.32, -32.83 -55.05, -15.97 APE12-dist-in 7.737 APE11-dist-in 10.95 APE10-dist-in 5.108 APE9-dist-out 6.047 None TPO183 TPO183 XRAY 3.4 0.218 0.245 A 503 362 0 0 0 0 [[27, 279]] 1.0 6e4t Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 4QFGA P54645 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.531 14.834 ABAminus -129.83, -31.53 -108.51, 95.59 -86.54, 22.6 280.04, 73.48 -69.33, -40.23 in-in in 8.767 Saltbr-in 2.778 HRD-out -72.26, 87.26 -69.37, 157.2 in-in-in SNCiii in-in ActLoopNT-in 2.811 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.6, 162.5 APE9-dihe-na 108.84, 159.63 APE8-dihe-in -59.24, 132.89 APE8-rot-in 308.45 APE67-dihe-in -56.78, -50.62 -41.69, -48.89 APE12-dist-in 7.804 APE11-dist-in 11.28 APE10-dist-in 5.635 APE9-dist-in 5.976 None TPO183 TPO183 XRAY 3.46 0.224 0.267 A 503 366 0 0 0 0 [[27, 279]] 1.0 4qfg Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 4QFRA P54645 20 559 559.0 STU:60601,32J:60606 Type1,Allosteric Inactive DFGin 7.179 14.461 ABAminus -135.94, -12.01 -110.66, 91.74 -85.33, 22.64 282.92, 78.98 -65.65, -45.25 in-in in 9.739 Saltbr-in 3.381 HRD-out -83.58, 90.91 -68.37, 165.86 in-in-out SNCiio in-out ActLoopNT-in 2.937 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -94.98, 155.0 APE9-dihe-na 104.66, 160.03 APE8-dihe-in -55.29, 137.08 APE8-rot-out 167.48 APE67-dihe-in -71.49, -40.84 -60.68, -24.54 APE12-dist-in 7.624 APE11-dist-in 11.161 APE10-dist-in 5.181 APE9-dist-out 6.055 None TPO183 TPO183 XRAY 3.34 0.212 0.249 A 503 362 0 0 0 0 [[27, 279]] 1.0 4qfr Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 4QFSA P54645 20 559 559.0 STU:60601,32H:60602 Type1,Allosteric Inactive DFGin 6.89 14.377 ABAminus -124.9, -28.24 -112.18, 85.76 -75.27, 7.65 284.68, 79.39 -57.92, -39.76 in-in in 9.764 Saltbr-in 3.467 HRD-out -68.1, 87.64 -69.41, 154.35 in-in-out SNCiio in-out ActLoopNT-in 2.903 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -125.95, 151.68 APE9-dihe-na 98.37, 158.77 APE8-dihe-in -43.48, 135.81 APE8-rot-out 168.88 APE67-dihe-in -73.46, -39.34 -64.14, -18.67 APE12-dist-in 7.721 APE11-dist-in 11.304 APE10-dist-in 5.545 APE9-dist-out 6.281 None TPO183 TPO183 XRAY 3.55 0.228 0.269 A 503 362 0 0 0 0 [[27, 279]] 1.0 4qfs Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 6E4UA P54645 20 559 559.0 STU:60601,HU7:60602 Type1,Allosteric Inactive DFGin 7.229 14.487 ABAminus -129.48, -32.52 -101.47, 99.32 -91.51, 18.06 282.35, 82.84 -62.17, -40.84 in-in in 9.777 Saltbr-in 2.9 HRD-out -78.35, 93.03 -70.69, 167.95 in-in-out SNCiio in-out ActLoopNT-in 2.908 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -104.64, -70.24 APE9-dihe-na -62.49, -169.58 APE8-dihe-in -69.59, 137.05 APE8-rot-out 166.67 APE67-dihe-in -62.15, -31.58 -48.72, -38.44 APE12-dist-in 7.888 APE11-dist-in 10.936 APE10-dist-in 5.302 APE9-dist-out 6.115 None TPO183 TPO183 XRAY 3.27 0.213 0.231 A 503 366 0 0 0 0 [[27, 279]] 1.0 6e4u Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 6E4WA P54645 20 559 559.0 STU:60601,HUG:60602 Type1,Allosteric Inactive DFGin 7.496 14.408 ABAminus -129.16, -43.82 -96.4, 98.46 -86.03, 19.41 285.3, 80.28 -65.13, -32.32 out-in out 10.281 Saltbr-in 3.414 HRD-out -66.89, 97.04 -81.94, 166.54 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -119.09, -68.02 APE9-dihe-na -76.27, -164.02 APE8-dihe-in -59.87, 132.49 APE8-rot-out 168.71 APE67-dihe-in -67.7, -51.69 -45.66, -33.67 APE12-dist-in 7.713 APE11-dist-in 10.871 APE10-dist-in 5.486 APE9-dist-out 6.081 None TPO183 TPO183 XRAY 3.35 0.21 0.244 A 503 362 0 0 0 0 [[27, 279]] 1.0 6e4w Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 5T5TA P54645 20 559 559.0 STU:60601 Type1 Inactive DFGin 7.275 14.446 BLAminus -131.93, 169.19 62.59, 84.7 -94.86, 17.97 279.02, 73.94 -55.16, -41.28 in-in in 9.798 Saltbr-in 3.171 HRD-out -77.74, 95.53 -76.17, 164.09 in-in-out SNCiio in-out ActLoopNT-in 2.838 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -99.9, 148.13 APE9-dihe-na 108.52, 171.16 APE8-dihe-in -60.68, 140.01 APE8-rot-out 180.44 APE67-dihe-in -65.41, -31.73 -60.15, -34.97 APE12-dist-in 7.797 APE11-dist-in 11.284 APE10-dist-in 5.316 APE9-dist-out 6.248 None TPO183 TPO183 XRAY 3.46 0.212 0.231 A 503 369 0 0 0 0 [[27, 279]] 1.0 5t5t Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 4CFHA P54645 21 481 559.0 STU:61550 Type1 Inactive DFGin 6.609 14.765 None -117.21, -79.88 -80.17, 112.56 -105.2, 27.91 278.75, 78.83 -62.93, -29.8 in-in in 9.294 Saltbr-in 2.664 HRD-out -123.7, 94.84 -71.28, 163.89 in-in-out SNCiio in-out ActLoopNT-in 3.029 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiio APE10-dihe-na -124.99, -9.44 APE9-dihe-na -61.07, -171.7 APE8-dihe-in -76.22, 167.06 APE8-rot-in 301.11 APE67-dihe-out -88.03, -177.87 -58.32, -48.27 APE12-dist-in 8.355 APE11-dist-in 10.864 APE10-dist-in 5.282 APE9-dist-out 6.078 None TPO183,TPO388 TPO183,TPO388 XRAY 3.24 0.234 0.268 A 493 402 0 0 0 0 [[27, 279]] 1.0 4cfh Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.7e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 5KQ5A P54645 21 559 559.0 STU:60601,6VT:60602 Type1,Allosteric Inactive DFGin 7.473 14.604 None -132.46, -37.52 -94.52, 85.46 -82.34, 16.94 281.45, 80.99 -67.49, -33.4 in-in in 9.898 Saltbr-in 3.252 HRD-out -71.96, 95.28 -74.85, 167.58 in-in-out SNCiio in-out ActLoopNT-in 2.882 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -101.64, 146.06 APE9-dihe-na 119.59, 166.41 APE8-dihe-in -64.65, 139.74 APE8-rot-out 166.73 APE67-dihe-in -69.09, -28.51 -58.99, -33.91 APE12-dist-in 7.87 APE11-dist-in 11.359 APE10-dist-in 5.426 APE9-dist-out 6.076 None TPO183 TPO183 XRAY 3.41 0.223 0.259 A 503 363 0 0 0 0 [[27, 279]] 1.0 5kq5 Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
STE TAOK2 TAOK2_RAT 2GCDA Q9JLS3 12 320 1235.0 STU:400 Type1 Active DFGin 7.553 13.911 BLAminus -132.94, -176.95 54.35, 85.93 -97.33, 11.47 293.74, 82.14 -43.28, -29.02 in-in in 8.703 Saltbr-in 2.666 HRD-in -73.77, -54.73 77.19, 2.76 in-in-in SNCiii in-in ActLoopNT-in 2.583 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.82, 161.5 APE9-dihe-na 135.37, -167.85 APE8-dihe-in -112.69, 128.97 APE8-rot-in 298.27 APE67-dihe-in -60.01, -20.68 -41.39, -55.54 APE12-dist-in 9.227 APE11-dist-in 11.165 APE10-dist-in 5.326 APE9-dist-in 2.941 None SEP181 SEP181 XRAY 2.55 0.203 0.261 A 309 309 0 0 0 0 [[28, 281]] 1.0 2gcd Rattus norvegicus STE_TAOK2_RAT STE 9.6e-90 306.4 2 257 256 168 169 170 172 174 57 76 80 148 150 149 151 207 192 187 186 185 184 183 182 181 106 Serine/threonine-protein kinase TAO2
STE TAOK2 TAOK2_RAT 2GCDB Q9JLS3 12 320 1235.0 STU:500 Type1 Active DFGin 7.453 13.677 BLAminus -123.25, 173.38 55.73, 83.59 -94.3, 26.26 300.5, 83.93 -55.16, -25.83 in-in in 8.613 Saltbr-in 3.014 HRD-in -78.82, -57.88 82.93, 0.43 in-in-in SNCiii in-in ActLoopNT-in 2.726 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.09, 152.57 APE9-dihe-na 123.5, -174.51 APE8-dihe-in -104.1, 125.98 APE8-rot-in 318.99 APE67-dihe-in -59.8, -23.52 -41.19, -51.52 APE12-dist-in 8.87 APE11-dist-in 11.056 APE10-dist-in 5.73 APE9-dist-in 3.13 None SEP181 SEP181 XRAY 2.55 0.203 0.261 B 309 309 0 0 0 0 [[28, 281]] 1.0 2gcd Rattus norvegicus STE_TAOK2_RAT STE 9.6e-90 306.4 2 257 256 168 169 170 172 174 57 76 80 148 150 149 151 207 192 187 186 185 184 183 182 181 106 Serine/threonine-protein kinase TAO2

Ligand: STU (Staurosporine)

Total number of chains: 23
Active chains: 3
Total number of genes: 9
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 12 52.2% 4C34A
DFGin BLAminus 7 30.4% 2GCDA
DFGin None 2 8.7% 4CFHA
DFGout None 2 8.7% 3D7TB
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL CTR1 CTR1_ARATH 3PPZA Q05609 540 810 821.0 STU:1 Type1 Active DFGin 7.168 14.176 BLAminus -141.04, 175.37 60.27, 75.13 -95.53, 20.67 299.73, 103.42 -61.37, -41.48 in-in in 9.236 Saltbr-in 3.099 HRD-in -68.66, -37.79 67.09, -5.56 in-in-in SNCiii in-in ActLoopNT-in 3.17 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.6, 161.97 APE9-dihe-na 135.37, 159.66 APE8-dihe-in -74.98, 124.27 APE8-rot-in 310.73 APE67-dihe-in -59.97, -23.72 -59.94, -40.82 APE12-dist-in 7.449 APE11-dist-in 10.756 APE10-dist-in 6.021 APE9-dist-in 3.962 None TPO704,SEP707,SEP710 TPO704,SEP707,SEP710 XRAY 2.99 0.204 0.256 A 309 267 4 0 0 0 [[551, 807]] 1.0 3ppz Arabidopsis thaliana TKL_CTR1_ARATH TKL 5e-79 271.5 2 265 264 693 694 695 697 699 578 596 600 673 675 674 676 733 721 716 715 714 713 712 711 710 626 Serine/threonine-protein kinase CTR1
TKL CTR1 CTR1_ARATH 3P86A Q05609 544 810 821.0 STU:0 Type1 Inactive DFGout 11.699 11.417 None -88.96, 103.02 -108.84, 121.4 -126.5, 999.0 59.02, 88.01 999.0, 999.0 out-out out 11.009 Saltbr-out 6.082 HRD-out -107.29, 93.48 -77.8, -17.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -129.5 APE8-dihe-in -88.96, 138.18 APE8-rot-out 51.6 APE67-dihe-in -62.6, -7.91 -94.5, 4.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.462 D676N None None XRAY 2.496 0.197 0.232 A 309 250 17 0 0 17 [[551, 807]] 1.0 3p86 Arabidopsis thaliana TKL_CTR1_ARATH TKL 3.2e-78 268.9 2 265 264 693 694 695 697 699 578 596 600 673 675 674 676 733 721 716 715 714 713 712 711 710 626 Serine/threonine-protein kinase CTR1
AGC GRK2 ARBK1_BOVIN 8JPBG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.508 12.214 ABAminus -113.28, -56.44 -93.74, 100.06 -93.25, 26.0 307.53, 3.55 -63.32, -43.2 in-out in 8.933 Saltbr-out 4.217 HRD-out -93.17, 87.64 -73.74, -9.71 out-in-in SNCoii in-in ActLoopNT-in 2.726 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.15, 142.89 APE9-dihe-na 142.59, -152.8 APE8-dihe-in -124.3, 137.48 APE8-rot-in 299.05 APE67-dihe-inflip 90.41, -8.27 -58.8, 137.88 APE12-dist-in 9.902 APE11-dist-in 12.01 APE10-dist-in 6.099 APE9-dist-in 3.63 A292P,R295I,S455D None None EM 3.07 999.0 999.0 G 688 658 0 0 0 0 [[191, 453]] 1.0 8jpb Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 8JPCG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.385 12.157 ABAminus -113.22, -56.58 -93.6, 101.44 -93.44, 27.48 306.81, 9.79 -63.79, -45.14 in-out in 8.989 Saltbr-out 4.654 HRD-out -92.62, 94.67 -75.66, -35.58 out-in-in SNCoii in-in ActLoopNT-in 2.653 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.27, 130.92 APE9-dihe-na 162.84, -151.71 APE8-dihe-in -129.7, 130.81 APE8-rot-in 302.62 APE67-dihe-inflip 97.48, -17.5 -57.09, 134.46 APE12-dist-in 9.713 APE11-dist-in 11.989 APE10-dist-in 5.989 APE9-dist-in 4.316 A292P,R295I,S455D None None EM 3.07 999.0 999.0 G 688 658 0 0 0 0 [[191, 453]] 1.0 8jpc Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 8JPDG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.385 12.157 ABAminus -113.24, -56.55 -93.57, 101.39 -93.42, 27.53 306.84, 9.79 -63.78, -45.12 in-out in 8.989 Saltbr-out 4.653 HRD-out -92.61, 94.65 -75.65, -35.58 out-in-in SNCoii in-in ActLoopNT-in 2.653 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.32, 130.92 APE9-dihe-na 162.83, -151.7 APE8-dihe-in -129.72, 130.82 APE8-rot-in 302.58 APE67-dihe-inflip 97.48, -17.49 -57.11, 134.43 APE12-dist-in 9.714 APE11-dist-in 11.989 APE10-dist-in 5.989 APE9-dist-in 4.317 A292P,R295I,S455D None None EM 2.81 999.0 999.0 G 688 658 0 0 0 0 [[191, 453]] 1.0 8jpd Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC PRKACA KAPCA_BOVIN 1STCE P00517 16 351 351.0 STU:60351 Type1 Inactive DFGin 6.125 14.676 ABAminus -152.28, -21.25 -98.94, 113.28 -112.23, 27.12 284.07, 102.64 -65.61, -29.61 in-in in 9.174 Saltbr-in 2.608 HRD-out -84.15, -57.61 42.07, 55.99 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.84, 156.46 APE9-dihe-na 129.45, -158.0 APE8-dihe-in -121.73, 124.56 APE8-rot-in 292.46 APE67-dihe-in -75.12, -21.46 -28.7, -46.78 APE12-dist-in 8.387 APE11-dist-in 11.162 APE10-dist-in 5.826 APE9-dist-in 4.443 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.3 0.208 0.33 E 350 336 0 0 0 0 [[44, 298]] 1.0 1stc Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 4C34A P00517 11 351 351.0 STU:61351 Type1 Inactive DFGin 6.517 14.849 ABAminus -119.31, -40.44 -98.64, 112.68 -107.28, 23.29 283.36, 88.13 -59.12, -19.89 in-in in 8.864 Saltbr-in 2.985 HRD-in -78.06, -54.1 69.84, 7.38 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.66, 162.66 APE9-dihe-na 118.12, -166.39 APE8-dihe-in -111.07, 134.19 APE8-rot-in 303.77 APE67-dihe-in -56.72, -26.94 -46.04, -52.13 APE12-dist-in 8.398 APE11-dist-in 11.458 APE10-dist-in 5.765 APE9-dist-in 3.408 F55Y,M121L,V124L,L174M,Q182K SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.78 0.18 0.214 A 351 340 0 0 0 0 [[44, 298]] 1.0 4c34 Bos taurus AGC_PRKACA_BOVIN AGC 7.8e-94 319.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
TYR SRC SRC_CHICK 3D7TB P00523 258 533 533.0 STU:6334 Type1 Inactive DFGout 12.814 10.121 None -137.48, -160.64 -79.66, 41.23 -140.31, 108.32 334.97, 53.33 120.28, -36.98 in-in in 8.029 Saltbr-in 2.622 HRD-in -81.72, -43.05 80.64, -35.93 in-out-none SNCion out-none ActLoopNT-out 5.413 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 102.99 APE9-dihe-in -85.23, 141.01 APE8-dihe-in -81.53, 111.41 APE8-rot-na 348.05 APE67-dihe-in -53.4, -28.51 -45.34, -53.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.29 APE9-dist-in 5.671 None None None XRAY 2.899 0.239 0.278 B 286 265 11 0 0 11 [[267, 518]] 1.0 3d7t Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR RTKC8 A9VBW0_MONBE 8E4TA A9VBW0 1412 1684 1911.0 STU:61901,STU:61902 Type1,Allosteric Inactive DFGin 5.798 14.258 BLAminus -127.66, 178.05 63.29, 82.89 -96.19, 23.12 289.39, 77.3 -56.36, -33.99 in-in in 8.035 Saltbr-in 2.897 HRD-in -84.2, -48.48 70.19, 15.14 in-in-out SNCiio in-out ActLoopNT-in 2.935 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.95, 2.58 APE9-dihe-in -47.64, 117.94 APE8-dihe-in -73.3, 83.54 APE8-rot-na 25.08 APE67-dihe-in -68.63, -15.26 -57.08, -37.63 APE12-dist-na 12.148 APE11-dist-na 14.573 APE10-dist-na 11.173 APE9-dist-out 8.027 None None None XRAY 1.95 0.206 0.255 A 283 268 5 0 0 5 [[1423, 1678]] 1.0 8e4t Monosiga brevicollis TYR_RTKC8_MONBE TYR 8.9e-85 290.0 3 260 258 1563 1564 1565 1567 1569 1455 1472 1476 1543 1545 1544 1546 1604 1592 1587 1586 1585 1584 1583 1582 1581 1502 non-specific protein-tyrosine kinase
CAMK PRKAA1 AAPK1_MOUSE 5UFUA Q5EG47 20 559 559.0 STU:60601,85V:60602 Type1,Allosteric Inactive DFGin 7.217 14.246 BLAminus -131.5, 162.6 65.85, 93.86 -99.38, 24.57 280.79, 65.36 -57.61, -46.84 in-in in 9.764 Saltbr-in 2.748 HRD-out -69.82, 100.36 -85.07, 166.65 in-in-out SNCiio in-out ActLoopNT-in 2.745 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -90.3, 155.77 APE9-dihe-na 100.05, 157.58 APE8-dihe-in -52.88, 143.31 APE8-rot-out 164.19 APE67-dihe-in -65.21, -41.11 -61.15, -33.48 APE12-dist-in 7.574 APE11-dist-in 11.095 APE10-dist-in 5.13 APE9-dist-out 6.066 None TPO183 TPO183 XRAY 3.45 0.195 0.238 A 503 249 0 0 0 0 [[27, 279]] 1.0 5ufu Mus musculus CAMK_PRKAA1_MOUSE CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
TKL RIPK4 RIPK4_MOUSE 5WNLA Q9ERK0 10 288 786.0 STU:401 Type1 Inactive DFGin 5.357 14.572 BLAminus -134.03, 174.48 63.33, 81.72 -96.92, 21.29 289.3, 76.96 -59.26, -33.93 in-in in 8.778 Saltbr-in 2.733 HRD-in -81.33, -54.8 69.56, 11.14 in-in-out SNCiio in-out ActLoopNT-in 3.066 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 144.67 APE9-dihe-na 85.9, -57.36 APE8-dihe-out -63.74, -13.96 APE8-rot-out 59.65 APE67-dihe-in -59.52, -31.71 -58.84, -41.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.665 APE9-dist-out 11.709 D143N None None XRAY 2.5 0.224 0.256 A 342 262 17 0 0 14 [[19, 285]] 1.0 5wnl Mus musculus TKL_RIPK4_MOUSE TKL 1.4e-74 257.0 4 266 263 160 161 162 164 166 51 69 73 140 142 141 143 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4
CAMK CDPK2 CDPK2_PLAFK 4MVFA O15865 60 511 513.0 STU:60601 Type1 Inactive DFGin 6.815 14.431 ABAminus -113.07, -2.16 -142.08, 130.21 -125.4, 28.29 288.94, 85.92 -61.14, -23.54 in-in in 9.439 Saltbr-in 2.78 HRD-in -82.17, -47.76 70.19, 0.74 in-in-none SNCiin in-none ActLoopNT-in 2.894 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.195 0.23 A 506 405 39 0 0 19 [[72, 326]] 1.0 4mvf Plasmodium falciparum CAMK_CDPK2_PLAFK CAMK 7.5e-88 300.5 1 256 256 212 213 214 216 218 101 117 121 189 191 190 192 250 239 234 233 232 231 230 229 228 147 Calcium-dependent protein kinase 2
CAMK PRKAA1 AAPK1_RAT 6E4TA P54645 20 559 559.0 HTV:60601,STU:60602 Allosteric,Type1 Inactive DFGin 7.435 14.261 ABAminus -127.14, -39.21 -103.64, 92.84 -85.31, 24.03 289.4, 72.26 -73.07, -34.04 out-in out 10.019 Saltbr-in 3.148 HRD-out -67.59, 99.51 -83.8, 164.42 in-in-out SNCiio in-out ActLoopNT-in 2.868 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -86.15, 147.86 APE9-dihe-na 86.15, 170.33 APE8-dihe-in -53.88, 128.36 APE8-rot-out 178.71 APE67-dihe-in -78.32, -32.83 -55.05, -15.97 APE12-dist-in 7.737 APE11-dist-in 10.95 APE10-dist-in 5.108 APE9-dist-out 6.047 None TPO183 TPO183 XRAY 3.4 0.218 0.245 A 503 362 0 0 0 0 [[27, 279]] 1.0 6e4t Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 4QFGA P54645 20 559 559.0 STU:60601 Type1 Inactive DFGin 6.531 14.834 ABAminus -129.83, -31.53 -108.51, 95.59 -86.54, 22.6 280.04, 73.48 -69.33, -40.23 in-in in 8.767 Saltbr-in 2.778 HRD-out -72.26, 87.26 -69.37, 157.2 in-in-in SNCiii in-in ActLoopNT-in 2.811 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.6, 162.5 APE9-dihe-na 108.84, 159.63 APE8-dihe-in -59.24, 132.89 APE8-rot-in 308.45 APE67-dihe-in -56.78, -50.62 -41.69, -48.89 APE12-dist-in 7.804 APE11-dist-in 11.28 APE10-dist-in 5.635 APE9-dist-in 5.976 None TPO183 TPO183 XRAY 3.46 0.224 0.267 A 503 366 0 0 0 0 [[27, 279]] 1.0 4qfg Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 4QFRA P54645 20 559 559.0 STU:60601,32J:60606 Type1,Allosteric Inactive DFGin 7.179 14.461 ABAminus -135.94, -12.01 -110.66, 91.74 -85.33, 22.64 282.92, 78.98 -65.65, -45.25 in-in in 9.739 Saltbr-in 3.381 HRD-out -83.58, 90.91 -68.37, 165.86 in-in-out SNCiio in-out ActLoopNT-in 2.937 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -94.98, 155.0 APE9-dihe-na 104.66, 160.03 APE8-dihe-in -55.29, 137.08 APE8-rot-out 167.48 APE67-dihe-in -71.49, -40.84 -60.68, -24.54 APE12-dist-in 7.624 APE11-dist-in 11.161 APE10-dist-in 5.181 APE9-dist-out 6.055 None TPO183 TPO183 XRAY 3.34 0.212 0.249 A 503 362 0 0 0 0 [[27, 279]] 1.0 4qfr Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 4QFSA P54645 20 559 559.0 STU:60601,32H:60602 Type1,Allosteric Inactive DFGin 6.89 14.377 ABAminus -124.9, -28.24 -112.18, 85.76 -75.27, 7.65 284.68, 79.39 -57.92, -39.76 in-in in 9.764 Saltbr-in 3.467 HRD-out -68.1, 87.64 -69.41, 154.35 in-in-out SNCiio in-out ActLoopNT-in 2.903 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -125.95, 151.68 APE9-dihe-na 98.37, 158.77 APE8-dihe-in -43.48, 135.81 APE8-rot-out 168.88 APE67-dihe-in -73.46, -39.34 -64.14, -18.67 APE12-dist-in 7.721 APE11-dist-in 11.304 APE10-dist-in 5.545 APE9-dist-out 6.281 None TPO183 TPO183 XRAY 3.55 0.228 0.269 A 503 362 0 0 0 0 [[27, 279]] 1.0 4qfs Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 6E4UA P54645 20 559 559.0 STU:60601,HU7:60602 Type1,Allosteric Inactive DFGin 7.229 14.487 ABAminus -129.48, -32.52 -101.47, 99.32 -91.51, 18.06 282.35, 82.84 -62.17, -40.84 in-in in 9.777 Saltbr-in 2.9 HRD-out -78.35, 93.03 -70.69, 167.95 in-in-out SNCiio in-out ActLoopNT-in 2.908 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -104.64, -70.24 APE9-dihe-na -62.49, -169.58 APE8-dihe-in -69.59, 137.05 APE8-rot-out 166.67 APE67-dihe-in -62.15, -31.58 -48.72, -38.44 APE12-dist-in 7.888 APE11-dist-in 10.936 APE10-dist-in 5.302 APE9-dist-out 6.115 None TPO183 TPO183 XRAY 3.27 0.213 0.231 A 503 366 0 0 0 0 [[27, 279]] 1.0 6e4u Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 6E4WA P54645 20 559 559.0 STU:60601,HUG:60602 Type1,Allosteric Inactive DFGin 7.496 14.408 ABAminus -129.16, -43.82 -96.4, 98.46 -86.03, 19.41 285.3, 80.28 -65.13, -32.32 out-in out 10.281 Saltbr-in 3.414 HRD-out -66.89, 97.04 -81.94, 166.54 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -119.09, -68.02 APE9-dihe-na -76.27, -164.02 APE8-dihe-in -59.87, 132.49 APE8-rot-out 168.71 APE67-dihe-in -67.7, -51.69 -45.66, -33.67 APE12-dist-in 7.713 APE11-dist-in 10.871 APE10-dist-in 5.486 APE9-dist-out 6.081 None TPO183 TPO183 XRAY 3.35 0.21 0.244 A 503 362 0 0 0 0 [[27, 279]] 1.0 6e4w Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 5T5TA P54645 20 559 559.0 STU:60601 Type1 Inactive DFGin 7.275 14.446 BLAminus -131.93, 169.19 62.59, 84.7 -94.86, 17.97 279.02, 73.94 -55.16, -41.28 in-in in 9.798 Saltbr-in 3.171 HRD-out -77.74, 95.53 -76.17, 164.09 in-in-out SNCiio in-out ActLoopNT-in 2.838 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -99.9, 148.13 APE9-dihe-na 108.52, 171.16 APE8-dihe-in -60.68, 140.01 APE8-rot-out 180.44 APE67-dihe-in -65.41, -31.73 -60.15, -34.97 APE12-dist-in 7.797 APE11-dist-in 11.284 APE10-dist-in 5.316 APE9-dist-out 6.248 None TPO183 TPO183 XRAY 3.46 0.212 0.231 A 503 369 0 0 0 0 [[27, 279]] 1.0 5t5t Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 4CFHA P54645 21 481 559.0 STU:61550 Type1 Inactive DFGin 6.609 14.765 None -117.21, -79.88 -80.17, 112.56 -105.2, 27.91 278.75, 78.83 -62.93, -29.8 in-in in 9.294 Saltbr-in 2.664 HRD-out -123.7, 94.84 -71.28, 163.89 in-in-out SNCiio in-out ActLoopNT-in 3.029 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiio APE10-dihe-na -124.99, -9.44 APE9-dihe-na -61.07, -171.7 APE8-dihe-in -76.22, 167.06 APE8-rot-in 301.11 APE67-dihe-out -88.03, -177.87 -58.32, -48.27 APE12-dist-in 8.355 APE11-dist-in 10.864 APE10-dist-in 5.282 APE9-dist-out 6.078 None TPO183,TPO388 TPO183,TPO388 XRAY 3.24 0.234 0.268 A 493 402 0 0 0 0 [[27, 279]] 1.0 4cfh Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.7e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_RAT 5KQ5A P54645 21 559 559.0 STU:60601,6VT:60602 Type1,Allosteric Inactive DFGin 7.473 14.604 None -132.46, -37.52 -94.52, 85.46 -82.34, 16.94 281.45, 80.99 -67.49, -33.4 in-in in 9.898 Saltbr-in 3.252 HRD-out -71.96, 95.28 -74.85, 167.58 in-in-out SNCiio in-out ActLoopNT-in 2.882 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -101.64, 146.06 APE9-dihe-na 119.59, 166.41 APE8-dihe-in -64.65, 139.74 APE8-rot-out 166.73 APE67-dihe-in -69.09, -28.51 -58.99, -33.91 APE12-dist-in 7.87 APE11-dist-in 11.359 APE10-dist-in 5.426 APE9-dist-out 6.076 None TPO183 TPO183 XRAY 3.41 0.223 0.259 A 503 363 0 0 0 0 [[27, 279]] 1.0 5kq5 Rattus norvegicus CAMK_PRKAA1_RAT CAMK 3.9e-89 304.5 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
STE TAOK2 TAOK2_RAT 2GCDA Q9JLS3 12 320 1235.0 STU:400 Type1 Active DFGin 7.553 13.911 BLAminus -132.94, -176.95 54.35, 85.93 -97.33, 11.47 293.74, 82.14 -43.28, -29.02 in-in in 8.703 Saltbr-in 2.666 HRD-in -73.77, -54.73 77.19, 2.76 in-in-in SNCiii in-in ActLoopNT-in 2.583 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.82, 161.5 APE9-dihe-na 135.37, -167.85 APE8-dihe-in -112.69, 128.97 APE8-rot-in 298.27 APE67-dihe-in -60.01, -20.68 -41.39, -55.54 APE12-dist-in 9.227 APE11-dist-in 11.165 APE10-dist-in 5.326 APE9-dist-in 2.941 None SEP181 SEP181 XRAY 2.55 0.203 0.261 A 309 309 0 0 0 0 [[28, 281]] 1.0 2gcd Rattus norvegicus STE_TAOK2_RAT STE 9.6e-90 306.4 2 257 256 168 169 170 172 174 57 76 80 148 150 149 151 207 192 187 186 185 184 183 182 181 106 Serine/threonine-protein kinase TAO2
STE TAOK2 TAOK2_RAT 2GCDB Q9JLS3 12 320 1235.0 STU:500 Type1 Active DFGin 7.453 13.677 BLAminus -123.25, 173.38 55.73, 83.59 -94.3, 26.26 300.5, 83.93 -55.16, -25.83 in-in in 8.613 Saltbr-in 3.014 HRD-in -78.82, -57.88 82.93, 0.43 in-in-in SNCiii in-in ActLoopNT-in 2.726 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.09, 152.57 APE9-dihe-na 123.5, -174.51 APE8-dihe-in -104.1, 125.98 APE8-rot-in 318.99 APE67-dihe-in -59.8, -23.52 -41.19, -51.52 APE12-dist-in 8.87 APE11-dist-in 11.056 APE10-dist-in 5.73 APE9-dist-in 3.13 None SEP181 SEP181 XRAY 2.55 0.203 0.261 B 309 309 0 0 0 0 [[28, 281]] 1.0 2gcd Rattus norvegicus STE_TAOK2_RAT STE 9.6e-90 306.4 2 257 256 168 169 170 172 174 57 76 80 148 150 149 151 207 192 187 186 185 184 183 182 181 106 Serine/threonine-protein kinase TAO2