JAK2 (Tyrosine-protein kinase JAK2)

JAK2 has two kinase domains in its sequence, labeled here as JAK2-1 and JAK2-2. Structures with both domains are given in the last table and labeled as JAK2-12.
Domain_1: JAK2-1 (Pseudokinase)
Group: TYR
Example Uniprot: JAK2_HUMAN
Domain boundary: 545 - 809

Total number of chains: 58
Spatial Dihedral Chains Representative
DFGin None 58 8BA3A
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment

Database table as tsv
Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens JAK2_HUMAN 8BA4B 2.1 Inactive DFGin None out-none out-out No_ligand No_ligand 536 - 809 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 4FVPA 2.01 Inactive DFGin None out-none out-out No_ligand No_ligand 536 - 809 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 8C09A 1.9 Inactive DFGin None out-none out-out No_ligand No_ligand 538 - 809 I559F,W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 5I4NA 1.54 Inactive DFGin None out-none out-out ATP Type1 537 - 809 E596A,V617F,W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 6G3CA 1.6 Inactive DFGin None in-none out-out EKT Type1 537 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 6G3CB 1.6 Inactive DFGin None in-none out-out EKT Type1 537 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 6D2IA 3.192 Inactive DFGin None in-none out-out 35R Type1 536 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 6D2IB 3.192 Inactive DFGin None in-none out-out 35R Type1 537 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 8B8NA 2.0 Inactive DFGin None out-none out-out AQG Type1 536 - 809 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 8B8UA 1.5 Inactive DFGin None in-none out-out T7I Type1 536 - 809 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 8B8UB 1.5 Inactive DFGin None in-none out-out T7I Type1 538 - 809 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 8BA2A 1.5 Inactive DFGin None out-none out-out Q9X Type1 536 - 810 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 8BA4A 2.1 Inactive DFGin None in-none out-out Q8U Type1 536 - 809 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 7F7WA 1.83 Inactive DFGin None out-none out-out 36H Type1 536 - 810 None None 0
Homo sapiens JAK2_HUMAN 7F7WB 1.83 Inactive DFGin None out-none out-out 36H Type1 536 - 810 None None 0
Homo sapiens JAK2_HUMAN 4FVRA 2.0 Inactive DFGin None out-none out-out ATP Type1 536 - 809 V617F,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 8B99A 1.6 Inactive DFGin None out-none out-out SKE Type1 536 - 809 W777A,F794H None 0
Homo sapiens JAK2_HUMAN 8B9EA 1.5 Inactive DFGin None out-none out-out Q7F Type1 536 - 809 W777A,F794H None 0
Homo sapiens JAK2_HUMAN 8BABA 1.55 Inactive DFGin None out-none out-out Q8N Type1 536 - 809 W777A,F794H None 0
Homo sapiens JAK2_HUMAN 8BAKA 1.65 Inactive DFGin None out-none out-out AD5 Type1 536 - 809 W777A,F794H None 0
Homo sapiens JAK2_HUMAN 8C0AA 1.7 Inactive DFGin None in-none out-out T7I Type1 536 - 809 W659A,R683S,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 8C0AB 1.7 Inactive DFGin None in-none out-out T7I Type1 536 - 808 W659A,R683S,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 5WIJA 2.04 Inactive DFGin None in-none out-out AQG Type1 536 - 809 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 5WIKB 2.6 Inactive DFGin None out-none out-out 584 Type1 536 - 809 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 5WILA 2.2 Inactive DFGin None out-none out-out YDJ Type1 536 - 809 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 5WIMA 2.55 Inactive DFGin None out-none out-out 35R Type1 536 - 809 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 5WINA 2.38 Inactive DFGin None out-none out-out SKE Type1 536 - 809 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 4FVQA 1.75 Inactive DFGin None out-none out-out ATP Type1 536 - 809 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 5USZA 2.103 Inactive DFGin None in-none out-out SKE Type1 537 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 5UT0A 2.102 Inactive DFGin None in-none out-out 35R Type1 537 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 5UT1A 1.95 Inactive DFGin None in-none out-out 7DZ Type1 537 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 5UT2A 1.75 Inactive DFGin None in-none out-out 3YT Type1 536 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 5UT3A 1.501 Inactive DFGin None in-none out-out IK1 Type1 537 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 5UT4A 2.0 Inactive DFGin None in-none out-out DQX Type1 537 - 809 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 5UT5A 1.9 Inactive DFGin None in-none out-out 2HB Type1 537 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 5UT6A 1.645 Inactive DFGin None in-none out-out 8MY Type1 537 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 6BRWA 2.031 Inactive DFGin None in-none out-out 5BS Type1 537 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 6BS0A 1.541 Inactive DFGin None in-none out-out E4V Type1 537 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 6BSSA 2.1 Inactive DFGin None in-none out-out 4SP Type1 537 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 6M9HA 1.79 Inactive DFGin None in-none out-out J9D Type1 536 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 6OAVA 1.939 Inactive DFGin None in-none out-out M3A Type1 537 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 6OBBA 1.904 Inactive DFGin None out-none out-out M3Y Type1 537 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 6OBFA 1.71 Inactive DFGin None out-none out-out M4G Type1 537 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 6OBLA 2.061 Inactive DFGin None out-none out-out M4P Type1 537 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 6OCCA 2.03 Inactive DFGin None out-none out-out M57 Type1 537 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 6XJKA 2.024 Inactive DFGin None out-none out-out V4D Type1 539 - 807 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 7JYOA 2.161 Inactive DFGin None in-none out-out VPS Type1 539 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 7JYQA 1.859 Inactive DFGin None out-none out-out VPJ Type1 537 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 7T0PA 2.04 Inactive DFGin None out-none out-out E3W Type1 536 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 7T0PB 2.04 Inactive DFGin None out-none out-out E3W Type1 536 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 7T1TA 2.08 Inactive DFGin None out-none out-out E8I Type1 536 - 809 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 8B9HA 1.5 Inactive DFGin None out-none out-out Q7F Type1 536 - 809 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 8BA3A 1.4 Inactive DFGin None out-none out-out Q8U Type1 536 - 812 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 8EX0A 1.85 Inactive DFGin None in-none out-out AQG Type1 536 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 8EX1A 1.5 Inactive DFGin None in-none out-out AD5 Type1 537 - 808 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 8C08A 2.2 Inactive DFGin None in-none out-out ATP Type1 537 - 810 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 8C08B 2.2 Inactive DFGin None out-none out-out ATP Type1 536 - 810 W659A,W777A,F794H None 0
Homo sapiens JAK2_HUMAN 8EX2A 1.9 Inactive DFGin None in-none out-out Q2Q Type1 536 - 808 W659A,W777A,F794H None 0

JAK2 (Tyrosine-protein kinase JAK2)

Domain_2: JAK2-2
Group: TYR
Example Uniprot: JAK2_MOUSE
Domain boundary: 849 - 1124

Total number of chains in: 179
Spatial Dihedral Chains Representative
DFGin BLAminus 46 AF-O60674-K2A
DFGin ABAminus 128 8BXHA
DFGin None 2 5TQ3A
DFGout BBAminus 3 3UGCA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment

Database table as tsv
Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens JAK2_HUMAN 5HEZA 2.66 Inactive DFGin ABAminus in-in in-out 1M3 1M3 Allosteric Type1 842 - 1132 P1057A X1007,X1008 0
Homo sapiens JAK2_HUMAN 5HEZB 2.66 Inactive DFGin ABAminus in-in in-out 1M3 1M3 Allosteric Type1 842 - 1132 P1057A X1007,X1008 0
Homo sapiens JAK2_HUMAN 5HEZD 2.66 Inactive DFGin ABAminus in-in in-out 1M3 1M3 Allosteric Type1 842 - 1132 P1057A X1007,X1008 0
Homo sapiens JAK2_HUMAN 7UYWA 2.51 Inactive DFGin ABAminus in-in in-in OV0 Type1 842 - 1131 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 6BBVA 1.8 Inactive DFGin ABAminus in-in in-in D7D Type1 843 - 1131 None None 0
Homo sapiens JAK2_HUMAN 6X8EA 1.75 Inactive DFGin ABAminus in-in in-in UWP Type1 843 - 1130 M1073S,F1076T X1007,X1008 0
Homo sapiens JAK2_HUMAN 6X8EB 1.75 Inactive DFGin ABAminus in-in in-in UWP Type1 843 - 1132 M1073S,F1076T X1007,X1008 0
Homo sapiens JAK2_HUMAN 7LL5A 1.5 Inactive DFGin ABAminus in-in in-in Y5G Type1 840 - 1132 None X1007 0
Homo sapiens JAK2_HUMAN 2B7AA 2.0 Inactive DFGin ABAminus in-in in-in IZA Type1 843 - 1132 N1129Q X1007,X1008 0
Homo sapiens JAK2_HUMAN 2B7AB 2.0 Inactive DFGin ABAminus in-in in-in IZA Type1 840 - 1132 N1129Q X1007,X1008 0
Homo sapiens JAK2_HUMAN 3FUPA 2.4 Inactive DFGin ABAminus in-in in-in MI1 Type1 843 - 1132 N1129Q X1007,X1008 0
Homo sapiens JAK2_HUMAN 3FUPB 2.4 Inactive DFGin ABAminus in-in in-in MI1 Type1 840 - 1132 N1129Q X1007,X1008 0
Homo sapiens JAK2_HUMAN 4P7EA 2.4 Inactive DFGin ABAminus in-in in-in 2HB Type1 843 - 1132 N1129Q X1007,X1008 0
Homo sapiens JAK2_HUMAN 4P7EB 2.4 Inactive DFGin ABAminus in-in in-in 2HB Type1 840 - 1132 N1129Q X1007,X1008 0
Homo sapiens JAK2_HUMAN 3E62A 1.922 Inactive DFGin ABAminus in-in in-in 5B1 Type1 839 - 1131 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 3E63A 1.9 Inactive DFGin ABAminus in-in in-in 5B2 Type1 840 - 1131 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 3E64A 1.8 Inactive DFGin ABAminus in-in in-in 5B3 Type1 839 - 1131 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 3KRRA 1.8 Inactive DFGin ABAminus in-in in-in DQX Type1 840 - 1131 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 3LPBA 2.0 Inactive DFGin ABAminus in-in in-in NVB Type1 842 - 1131 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 3LPBB 2.0 Inactive DFGin ABAminus in-in in-in NVB Type1 840 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 5TQ6A 2.06 Inactive DFGin ABAminus in-in in-in 7GV Type1 843 - 1132 M1073S,F1076T X1007,X1008 0
Homo sapiens JAK2_HUMAN 5TQ6B 2.06 Inactive DFGin ABAminus in-in in-in 7GV Type1 843 - 1130 M1073S,F1076T X1007,X1008 0
Homo sapiens JAK2_HUMAN 5TQ7A 2.1 Inactive DFGin ABAminus in-in in-in 7GT Type1 841 - 1132 M1073S,F1076T,I1126V X1007,X1008 0
Homo sapiens JAK2_HUMAN 5TQ7B 2.1 Inactive DFGin ABAminus in-in in-in 7GT Type1 843 - 1132 M1073S,F1076T,I1126V X1007,X1008 0
Homo sapiens JAK2_HUMAN 7LL4A 1.31 Inactive DFGin ABAminus in-in in-in Y5D Type1 839 - 1132 None X1007 0
Homo sapiens JAK2_HUMAN 7REEA 1.38 Inactive DFGin ABAminus in-in in-in 4LY Type1 839 - 1130 None X1007 0
Homo sapiens JAK2_HUMAN 4D0WA 1.77 Inactive DFGin ABAminus in-in in-in VVQ Type1 839 - 1130 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4D0XA 1.82 Inactive DFGin ABAminus in-in in-in 953 Type1 839 - 1131 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 5AEPA 1.95 Inactive DFGin ABAminus in-in in-in QUP Type1 840 - 1131 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 3TJCA 2.4 Inactive DFGin ABAminus in-in in-in 0TP Type1 843 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 3TJCB 2.4 Inactive DFGin ABAminus in-in in-in 0TP Type1 840 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 3TJDA 2.9 Inactive DFGin ABAminus in-in in-in 6TP Type1 843 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 3TJDB 2.9 Inactive DFGin ABAminus in-in in-in 6TP Type1 840 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4HGEA 2.3 Inactive DFGin ABAminus in-in in-in 15V Type1 843 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4HGEB 2.3 Inactive DFGin ABAminus in-in in-in 15V Type1 839 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4IVAA 1.5 Inactive DFGin ABAminus in-in in-in 1J5 Type1 841 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4JI9A 2.4 Inactive DFGin ABAminus in-in in-out 1M3 Type1 843 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4JI9B 2.4 Inactive DFGin ABAminus in-in in-in 1M3 Type1 839 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 3Q32A 2.5 Inactive DFGin ABAminus in-in in-in J2I Type1 840 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 3Q32B 2.5 Inactive DFGin ABAminus in-in in-in J2I Type1 839 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 5CF8A 1.8 Inactive DFGin ABAminus in-in in-in 50V Type1 842 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 5CF8B 1.8 Inactive DFGin ABAminus in-in in-in 50V Type1 839 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4AQCA 1.9 Inactive DFGin ABAminus in-in in-in 88A Type1 842 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4AQCB 1.9 Inactive DFGin ABAminus in-in in-in 88A Type1 836 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4F08A 2.82 Inactive DFGin ABAminus in-in in-in 1RS Type1 843 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4F08B 2.82 Inactive DFGin ABAminus in-in in-in 1RS Type1 843 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4F09A 2.4 Inactive DFGin ABAminus in-in in-in JAK Type1 843 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4GFMA 2.3 Inactive DFGin ABAminus in-in in-in 0X2 Type1 840 - 1130 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 3RVGA 2.498 Inactive DFGin ABAminus in-in in-in 17P Type1 841 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 6VGLA 1.9 Inactive DFGin ABAminus in-in in-in RXT Type1 840 - 1132 None X1007 0
Homo sapiens JAK2_HUMAN 6VGLB 1.9 Inactive DFGin ABAminus in-in in-in RXT Type1 840 - 1132 None X1007 0
Homo sapiens JAK2_HUMAN 6VGLC 1.9 Inactive DFGin ABAminus in-in in-in RXT Type1 843 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6VGLD 1.9 Inactive DFGin ABAminus in-in in-in RXT Type1 843 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6VN8A 1.9 Inactive DFGin ABAminus in-in in-in 3JW Type1 840 - 1132 None X1007 0
Homo sapiens JAK2_HUMAN 6VN8B 1.9 Inactive DFGin ABAminus in-in in-in 3JW Type1 843 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6VNBA 2.19 Inactive DFGin ABAminus in-in in-in R6P Type1 840 - 1132 None X1007 0
Homo sapiens JAK2_HUMAN 6VNBB 2.19 Inactive DFGin ABAminus in-in in-in R6P Type1 843 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6VNCA 2.3 Inactive DFGin ABAminus in-in in-in R6V Type1 840 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6VNCB 2.3 Inactive DFGin ABAminus in-in in-in R6V Type1 843 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6VNEA 2.32 Inactive DFGin ABAminus in-in in-in 2TA Type1 840 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6VNEB 2.32 Inactive DFGin ABAminus in-in in-out 2TA Type1 843 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6VNFA 2.06 Inactive DFGin ABAminus in-in in-in R6S Type1 840 - 1132 None X1007 0
Homo sapiens JAK2_HUMAN 6VNFB 2.06 Inactive DFGin ABAminus in-in in-out R6S Type1 841 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6VNGA 2.5 Inactive DFGin ABAminus in-in in-in R6M Type1 841 - 1132 None X1007 0
Homo sapiens JAK2_HUMAN 6VNGB 2.5 Inactive DFGin ABAminus in-in in-in R6M Type1 843 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6VNHA 2.4 Inactive DFGin ABAminus in-in in-in XZS Type1 840 - 1132 None X1007 0
Homo sapiens JAK2_HUMAN 6VNHB 2.4 Inactive DFGin ABAminus in-in in-out XZS Type1 843 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6VNIA 2.1 Inactive DFGin ABAminus in-in in-in R61 Type1 842 - 1132 None X1007 0
Homo sapiens JAK2_HUMAN 6VNIB 2.1 Inactive DFGin ABAminus in-in in-out R61 Type1 843 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6VNJA 1.9 Inactive DFGin ABAminus in-in in-in R5S Type1 840 - 1132 None X1007 0
Homo sapiens JAK2_HUMAN 6VNJB 1.9 Inactive DFGin ABAminus in-in in-in R5S Type1 842 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6VNKA 2.0 Inactive DFGin ABAminus in-in in-in RXT Type1 840 - 1132 None X1007 0
Homo sapiens JAK2_HUMAN 6VNKB 2.0 Inactive DFGin ABAminus in-in in-in RXT Type1 840 - 1132 None X1007 0
Homo sapiens JAK2_HUMAN 6VNKC 2.0 Inactive DFGin ABAminus in-in in-out RXT Type1 843 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6VNKD 2.0 Inactive DFGin ABAminus in-in in-in RXT Type1 843 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6VNLA 2.4 Inactive DFGin ABAminus in-in in-in 5W2 Type1 840 - 1132 None X1007 0
Homo sapiens JAK2_HUMAN 6VNLB 2.4 Inactive DFGin ABAminus in-in in-in 5W2 Type1 840 - 1132 None X1007 0
Homo sapiens JAK2_HUMAN 6VNLC 2.4 Inactive DFGin ABAminus in-in in-out 5W2 Type1 842 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6VNLD 2.4 Inactive DFGin ABAminus in-in in-out 5W2 Type1 843 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6VNMA 2.2 Inactive DFGin ABAminus in-in in-in R5Y Type1 840 - 1132 None X1007 0
Homo sapiens JAK2_HUMAN 6VNMB 2.2 Inactive DFGin ABAminus in-in in-in R5Y Type1 843 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6VS3A 2.0 Inactive DFGin ABAminus in-in in-in R6V Type1 843 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6VS3B 2.0 Inactive DFGin ABAminus in-in in-in R6V Type1 840 - 1132 None X1007 0
Homo sapiens JAK2_HUMAN 6VSNA 2.5 Inactive DFGin ABAminus in-in in-in RG4 Type1 840 - 1132 None X1007 0
Homo sapiens JAK2_HUMAN 6VSNB 2.5 Inactive DFGin ABAminus in-in in-in RG4 Type1 842 - 1132 None X1007 0
Homo sapiens JAK2_HUMAN 6VSNC 2.5 Inactive DFGin ABAminus in-in in-in RG4 Type1 843 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6VSND 2.5 Inactive DFGin ABAminus in-in in-in RG4 Type1 843 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 6WTNA 1.83 Inactive DFGin ABAminus in-in in-in RXT Type1 843 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 6WTOA 1.74 Inactive DFGin ABAminus in-in in-in 3JW Type1 843 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 6WTPA 2.5 Inactive DFGin ABAminus in-in in-in U8P Type1 844 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 6WTQA 1.8 Inactive DFGin ABAminus in-in in-out U8J Type1 849 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 8G6ZA 2.45 Inactive DFGin ABAminus in-in in-in YSI Type1 843 - 1131 M1073S,F1076T X1007 0
Homo sapiens JAK2_HUMAN 8G6ZB 2.45 Inactive DFGin ABAminus in-in in-in YSI Type1 843 - 1131 M1073S,F1076T X1007 0
Homo sapiens JAK2_HUMAN 8G8OA 2.2 Inactive DFGin ABAminus in-in in-in YT0 Type1 842 - 1130 M1073S,F1076T X1007,X1008 0
Homo sapiens JAK2_HUMAN 8G8OB 2.2 Inactive DFGin ABAminus in-in in-in YT0 Type1 843 - 1130 M1073S,F1076T X1007,X1008 0
Homo sapiens JAK2_HUMAN 8G8XA 1.97 Inactive DFGin ABAminus in-in in-in YT8 Type1 842 - 1130 M1073S,F1076T X1007,X1008 0
Homo sapiens JAK2_HUMAN 8G8XB 1.97 Inactive DFGin ABAminus in-in in-in YT8 Type1 842 - 1130 M1073S,F1076T X1007,X1008 0
Homo sapiens JAK2_HUMAN 3IO7A 2.6 Inactive DFGin ABAminus in-in in-in 1P5 Type1 842 - 1130 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 3IOKA 2.1 Inactive DFGin ABAminus in-in in-in 1P6 Type1 842 - 1130 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 8BX9A 1.4 Inactive DFGin ABAminus in-in in-in S59 Type1 840 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 8BX9B 1.4 Inactive DFGin ABAminus in-in in-in S59 Type1 840 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 8BXCA 1.9 Inactive DFGin ABAminus in-in in-in S4R Type1 840 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 8BXCB 1.9 Inactive DFGin ABAminus in-in in-in S4R Type1 840 - 1131 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 8BXHA 1.3 Inactive DFGin ABAminus in-in in-in C87 Type1 840 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 8BPVA 1.7 Inactive DFGin ABAminus in-in in-in 6T3 Type1 840 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 8BPWA 1.8 Inactive DFGin ABAminus in-in in-in 2V9 Type1 840 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 8BPWB 1.8 Inactive DFGin ABAminus in-in in-in 2V9 Type1 840 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4ZIMA 2.65 Inactive DFGin ABAminus in-in in-in 4OK Type1 842 - 1131 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4ZIMB 2.65 Inactive DFGin ABAminus in-in in-in 4OK Type1 839 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 5CF4A 2.38 Inactive DFGin ABAminus in-in in-in 50Y Type1 843 - 1131 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 5CF4B 2.38 Inactive DFGin ABAminus in-in in-in 50Y Type1 839 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 5CF5A 2.45 Inactive DFGin ABAminus in-in in-out 50W Type1 842 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 5CF5B 2.45 Inactive DFGin ABAminus in-in in-in 50W Type1 839 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 5CF6A 2.5 Inactive DFGin ABAminus in-in in-in 50O Type1 842 - 1131 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 5CF6B 2.5 Inactive DFGin ABAminus in-in in-in 50O Type1 839 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4E6DA 2.22 Inactive DFGin ABAminus in-in in-in 0NU Type1 840 - 1132 Q853R,Y931F,D939E X1007,X1008 0
Homo sapiens JAK2_HUMAN 4E6DB 2.22 Inactive DFGin ABAminus in-in in-in 0NU Type1 840 - 1132 Q853R,Y931F,D939E X1007,X1008 0
Homo sapiens JAK2_HUMAN 4E6QA 1.948 Inactive DFGin ABAminus in-in in-out 0NV Type1 835 - 1132 Q853R,Y931F,D939E X1007,X1008 0
Homo sapiens JAK2_HUMAN 4E6QB 1.948 Inactive DFGin ABAminus in-in in-out 0NV Type1 835 - 1132 Q853R,Y931F,D939E X1007,X1008 0
Homo sapiens JAK2_HUMAN 2XA4A 2.04 Inactive DFGin ABAminus in-in in-in AZ5 Type1 843 - 1130 K943A,K945A X1007,X1008 0
Homo sapiens JAK2_HUMAN 2XA4B 2.04 Inactive DFGin ABAminus in-in in-in AZ5 Type1 843 - 1131 K943A,K945A X1007,X1008 0
Homo sapiens JAK2_HUMAN 3ZMMA 2.51 Inactive DFGin ABAminus in-in in-in F9J Type1 844 - 1130 K943A,K945A X1007,X1008 0
Homo sapiens JAK2_HUMAN 3ZMMB 2.51 Inactive DFGin ABAminus in-in in-in F9J Type1 843 - 1131 K943A,K945A X1007,X1008 0
Homo sapiens JAK2_HUMAN 4C61A 2.45 Inactive DFGin ABAminus in-in in-in LMM Type1 844 - 1130 K943A,K945A X1007,X1008 0
Homo sapiens JAK2_HUMAN 4C61B 2.45 Inactive DFGin ABAminus in-in in-in LMM Type1 843 - 1131 K943A,K945A X1007,X1008 0
Homo sapiens JAK2_HUMAN 4C62A 2.75 Inactive DFGin ABAminus in-in in-in XWW Type1 844 - 1130 K943A,K945A X1007,X1008 0
Homo sapiens JAK2_HUMAN 4C62B 2.75 Inactive DFGin ABAminus in-in in-in XWW Type1 843 - 1131 K943A,K945A X1007,X1008 0
Homo sapiens JAK2_HUMAN 5HEZC 2.66 Inactive DFGin ABAminus in-in in-out 1M3 1M3 Type1 Allosteric 842 - 1132 P1057A X1007,X1008 0
Homo sapiens JAK2_HUMAN AF-O60674-K2A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 841 - 1132 None None 0
Homo sapiens JAK2_HUMAN 2W1IB 2.6 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 843 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4YTCA 2.16 Active DFGin BLAminus in-in in-in 4HW Type1 842 - 1130 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4YTFA 1.78 Active DFGin BLAminus in-in in-in 4HZ Type1 842 - 1130 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4YTHA 2.04 Active DFGin BLAminus in-in in-in 467 Type1 842 - 1130 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4YTIA 2.52 Active DFGin BLAminus in-in in-in VJK Type1 842 - 1130 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4D1SA 1.66 Active DFGin BLAminus in-in in-in BJG Type1 842 - 1130 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4JIAA 1.85 Active DFGin BLAminus in-in in-in 1K3 Type1 833 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4E4MA 2.25 Active DFGin BLAminus in-in in-in 0NH Type1 835 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4E4MB 2.25 Active DFGin BLAminus in-in in-in 0NH Type1 835 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4E4MD 2.25 Active DFGin BLAminus in-in in-in 0NH Type1 835 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4E4ME 2.25 Active DFGin BLAminus in-in in-in 0NH Type1 835 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 4GMYA 2.403 Active DFGin BLAminus in-in in-in 0X5 Type1 833 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 8BX6A 1.5 Active DFGin BLAminus in-in in-in S5I Type1 840 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 5USYA 2.0 Active DFGin BLAminus in-in in-in SKE Type1 840 - 1130 None X1007 0
Homo sapiens JAK2_HUMAN 5USYB 2.0 Active DFGin BLAminus in-in in-in SKE Type1 840 - 1130 None X1007 0
Homo sapiens JAK2_HUMAN 6DRWA 2.303 Inactive DFGin BLAminus in-out in-in SKE Type1 840 - 1131 None X1007 0
Homo sapiens JAK2_HUMAN 8BM2A 1.5 Active DFGin BLAminus in-in in-in QQC Type1 840 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 8BM2B 1.5 Active DFGin BLAminus in-in in-in QQC Type1 840 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 5WEVA 1.854 Active DFGin BLAminus in-in in-in 9ZS Type1 833 - 1130 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 2W1IA 2.6 Active DFGin BLAminus in-in in-in L0I Type1 843 - 1132 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 6TPDA 1.99 Active DFGin BLAminus in-in in-in QZ8 Type1 842 - 1130 None None 0
Homo sapiens JAK2_HUMAN 5L3AA 1.98 Active DFGin BLAminus in-in in-in 6DP Type1 841 - 1130 Y1007F,Y1008F None 0
Homo sapiens JAK2_HUMAN 6AAJA 2.37 Active DFGin BLAminus in-in in-in 9T6 Type1 843 - 1130 K943A,K945A X1007,X1008 0
Homo sapiens JAK2_HUMAN 6AAJB 2.37 Active DFGin BLAminus in-in in-in 9T6 Type1 843 - 1131 K943A,K945A X1007,X1008 0
Homo sapiens JAK2_HUMAN 4BBEA 1.9 Active DFGin BLAminus in-in in-in 3O4 Type1 841 - 1128 D976N None 0
Homo sapiens JAK2_HUMAN 4BBEB 1.9 Active DFGin BLAminus in-in in-in 3O4 Type1 841 - 1128 D976N None 0
Homo sapiens JAK2_HUMAN 4BBEC 1.9 Active DFGin BLAminus in-in in-in 3O4 Type1 841 - 1128 D976N None 0
Homo sapiens JAK2_HUMAN 4BBED 1.9 Active DFGin BLAminus in-in in-in 3O4 Type1 841 - 1128 D976N None 0
Homo sapiens JAK2_HUMAN 4BBFA 2.0 Active DFGin BLAminus in-in in-in O19 Type1 841 - 1128 D976N None 0
Homo sapiens JAK2_HUMAN 4BBFB 2.0 Active DFGin BLAminus in-in in-in O19 Type1 841 - 1128 D976N None 0
Homo sapiens JAK2_HUMAN 4BBFC 2.0 Active DFGin BLAminus in-in in-in O19 Type1 841 - 1128 D976N None 0
Homo sapiens JAK2_HUMAN 4BBFD 2.0 Active DFGin BLAminus in-in in-in O19 Type1 841 - 1128 D976N None 0
Homo sapiens JAK2_HUMAN 5TQ4A 2.3 Inactive DFGin BLAminus in-in in-out 7GY Type1.5_Back 841 - 1132 M1073S,F1076T X1007,X1008 0
Homo sapiens JAK2_HUMAN 5TQ5A 2.3 Active DFGin BLAminus in-in in-in 7GX Type1.5_Back 841 - 1131 M1073S,F1076T None 0
Homo sapiens JAK2_HUMAN 5TQ8A 1.59 Active DFGin BLAminus in-in in-in 7GS Type1.5_Back 841 - 1131 M1073S,F1076T None 0
Homo sapiens JAK2_HUMAN 7Q7IA 1.78 Active DFGin BLAminus in-in in-in 9I8 Type1.5_Back 840 - 1131 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 7Q7KA 1.61 Active DFGin BLAminus in-in in-in 9I5 Type1.5_Back 840 - 1131 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 7Q7LA 1.97 Active DFGin BLAminus in-in in-in 9I2 Type1.5_Back 843 - 1131 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 7Q7WA 1.85 Active DFGin BLAminus in-in in-in 9HR Type1.5_Back 840 - 1131 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 3JY9A 2.1 Active DFGin BLAminus in-in in-in JZH Type1.5_Back 842 - 1130 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 3KCKA 2.2 Active DFGin BLAminus in-in in-in 3KC Type1.5_Back 842 - 1130 None X1007,X1008 0
Homo sapiens JAK2_HUMAN 5TQ3A 2.69 Inactive DFGin None in-in in-in 7GZ Type1.5_Back 843 - 1132 M1073S,F1076T,I1126V X1007,X1008 0
Homo sapiens JAK2_HUMAN 5TQ3B 2.69 Inactive DFGin None in-in in-in 7GZ Type1.5_Back 843 - 1132 M1073S,F1076T,I1126V X1007,X1008 0
Homo sapiens JAK2_HUMAN 7RN6A 1.5 Inactive DFGout BBAminus in-in none-out 046 Type2 839 - 1130 None X1007 0
Homo sapiens JAK2_HUMAN 3UGCA 1.34 Inactive DFGout BBAminus in-in out-out 046 Type2 843 - 1129 Y1007F,Y1008F None 0
Homo sapiens JAK2_HUMAN 7TEUA 1.45 Inactive DFGout BBAminus in-in out-out I6C Type2 843 - 1131 Y1007F,Y1008F None 0
Mus musculus JAK2_MOUSE 4GL9A 3.9 Inactive DFGin BLAminus in-in in-out IZA Type1 843 - 1130 None X1007,X1008 0
Mus musculus JAK2_MOUSE 4GL9B 3.9 Inactive DFGin BLAminus in-in in-out IZA Type1 843 - 1130 None X1007,X1008 0
Mus musculus JAK2_MOUSE 4GL9C 3.9 Inactive DFGin BLAminus in-in in-out IZA Type1 843 - 1130 None X1007,X1008 0
Mus musculus JAK2_MOUSE 4GL9D 3.9 Active DFGin BLAminus in-in in-in IZA Type1 843 - 1130 None X1007,X1008 0

JAK2 (Tyrosine-protein kinase JAK2)

Domain_12: JAK2-12
Total number of chains in: 0. Analysis of 2nd kinase domain given in table below.