5CF8

JAK2 (Tyrosine-protein kinase JAK2)
Group: TYR
Uniprot: JAK2_HUMAN
Organism: Homo sapiens
Domain boundary: 849 - 1124
Resolu: 1.8

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin ABAminus in-in in-in 50V Type1 842 - 1132 0
B Inactive DFGin ABAminus in-in in-in 50V Type1 839 - 1132 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
       847        857        867        877 
mRDPTQFEER HLKFLQQLGK GNFGSVEMCR YDPLQDNTGE 
       887        897        907        917 
VVAVKKLQHS TEEHLRDFER EIEILKSLQH DNIVKYKGVC 
       927        937        947        957 
YsagrrNLKL IMEYLPYGSL RDYLQKHKER IDHIKLLQYT 
       967        977        987        997 
SQICKGMEYL GTKRYIHRDL ATRNILVENE NRVKIGDFGL 
      1007       1017       1027       1037 
TKVLPQDKEY YKVKEPGESP IFWYAPESLT ESKFSVASDV 
      1047       1057       1067       1077 
WSFGVVLYEL FTYIEKSKSP PAEFMRMIGN DKQGQMIVFH 
      1087       1097       1107       1117 
LIELLKNNGR LPRPDGCPDE IYMIMTECWN NNVNQRPSFR 
      1127          - 
DLALRVDQIR DNMAGHhhhh h
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X1007,X1008