3E63

JAK2 (Tyrosine-protein kinase JAK2)
Group: TYR
Uniprot: JAK2_HUMAN
Organism: Homo sapiens
Domain boundary: 849 - 1124
Resolu: 1.9

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin ABAminus in-in in-in 5B2 Type1 840 - 1131 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
       848        858        868        878 
rDPTQFEERH LKFLQQLGKG NFGSVEMCRY DPLQDNTGEV 
       888        898        908        918 
VAVKKLQHST EEHLRDFERE IEILKSLQHD NIVKYKGVCY 
       928        938        948        958 
SAGRRNLKLI MEYLPYGSLR DYLQKHKERI DHIKLLQYTS 
       968        978        988        998 
QICKGMEYLG TKRYIHRDLA TRNILVENEN RVKIGDFGLT 
      1008       1018       1028       1038 
KVLPQDKEYY KVKEPGESPI FWYAPESLTE SKFSVASDVW 
      1048       1058       1068       1078 
SFGVVLYELF TYIEKSKSPP AEFMRMIGND KQGQMIVFHL 
      1088       1098       1108       1118 
IELLKNNGRL PRPDGCPDEI YMIMTECWNN NVNQRPSFRD 
      1128 
LALRVDQIRD NMA
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X1007,X1008