2W1I

JAK2 (Tyrosine-protein kinase JAK2)
Group: TYR
Uniprot: JAK2_HUMAN
Organism: Homo sapiens
Domain boundary: 849 - 1124
Resolu: 2.6

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in L0I Type1 843 - 1132 0
B Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 843 - 1132 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
         -        821        836        846 
msyyhhhhhh dydipttenl yfqgamgsaf edrdptQFEE 
       856        866        876        886 
RHLKFLQQLG KGNFGSVEMC RYDPLQDNTG EVVAVKKLQH 
       896        906        916        926 
STEEHLRDFE REIEILKSLQ HDNIVKYKGV CYSagrrNLK 
       936        946        956        966 
LIMEYLPYGS LRDYLQKHKE RIDHIKLLQY TSQICKGMEY 
       976        986        996       1006 
LGTKRYIHRD LATRNILVEN ENRVKIGDFG LTKVLPQDKE 
      1016       1026       1036       1046 
YYKVKEPGES PIFWYAPESL TESKFSVASD VWSFGVVLYE 
      1056       1066       1076       1086 
LFTYIEKSKS PPAEFMRMIG NDKQGQMIVF HLIELLKNNG 
      1096       1106       1116       1126 
RLPRPDGCPD EIYMIMTECW NNNVNQRPSF RDLALRVDQI 

RDQMAG
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X1007,X1008