5TQ5

JAK2 (Tyrosine-protein kinase JAK2)
Group: TYR
Uniprot: JAK2_HUMAN
Organism: Homo sapiens
Domain boundary: 849 - 1124
Resolu: 2.3

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in 7GX Type1.5_Back 841 - 1131 0
Representative sequence - Chain A
844 854 864 874
gsedrdPTQF EERHLKFLQQ LGKGNFGSVE MCRYDPLQDN
884 894 904 914
TGEVVAVKKL QHSTEEHLRD FEREIEILKS LQHDNIVKYK
924 934 944 954
GVCYSAGRRN LKLIMEYLPY GSLRDYLQKH KERIDHIKLL
964 974 984 994
QYTSQICKGM EYLGTKRYIH RDLATRNILV ENENRVKIGD
1004 1014 1024 1034
FGLTKVLPQD KEYYKVKEPG ESPIFWYAPE SLTESKFSVA
1044 1054 1064 1074
SDVWSFGVVL YELFTYIEKS KSPPAEFMRM IGNDKQGQSI
1084 1094 1104 1114
VTHLIELLKN NGRLPRPDGC PDEIYMIMTE CWNNNVNQRP
1124
SFRDLALRVD QIRDNMAg
Lower-case residues are disordered in structure.
Mutations: M1073S,F1076T
Phosphorylation: None