We provide a structure-based multiple sequence alignment of 497 human protein kinase domains. The alignment is parsimonious and arranged in 17 blocks of conserved elements like C-helix, HRD and DFG motifs etc in upper case letters. These are separated by left-justified unaligned sequence containing insertions of different lengths in lower case letters.The list of conserved blocks and corresponding structural elements is displayed in the table and the figure.

The alignment could be accessed in the following ways: