5CF6

JAK2 (Tyrosine-protein kinase JAK2)
Group: TYR
Uniprot: JAK2_HUMAN
Organism: Homo sapiens
Domain boundary: 849 - 1124
Resolu: 2.5

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin ABAminus in-in in-in 50O Type1 842 - 1131 0
B Inactive DFGin ABAminus in-in in-in 50O Type1 839 - 1132 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
         -          -        847        857 
mgsshhhhhh ssglvprgsh MRDPTQFEER HLKFLQQLGK 
       867        877        887        897 
GNFGSVEMCR YDPLQDNTGE VVAVKKLQHS TEEHLRDFER 
       907        917        927        937 
EIEILKSLQH DNIVKYKGVC YsagrRNLKL IMEYLPYGSL 
       947        957        967        977 
RDYLQKHKER IDHIKLLQYT SQICKGMEYL GTKRYIHRDL 
       987        997       1007       1017 
ATRNILVENE NRVKIGDFGL TKVLPQDKEY YKVKEPGESP 
      1027       1037       1047       1057 
IFWYAPESLT ESKFSVASDV WSFGVVLYEL FTYIEKSKSP 
      1067       1077       1087       1097 
PAEFMRMIGN DKQGQMIVFH LIELLKNNGR LPRPDGCPDE 
      1107       1117       1127          - 
IYMIMTECWN NNVNQRPSFR DLALRVDQIR DNMAGHhhhh 

h
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X1007,X1008