4C62

JAK2 (Tyrosine-protein kinase JAK2)
Group: TYR
Uniprot: JAK2_HUMAN
Organism: Homo sapiens
Domain boundary: 849 - 1124
Resolu: 2.75

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin ABAminus in-in in-in XWW Type1 844 - 1130 0
B Inactive DFGin ABAminus in-in in-in XWW Type1 843 - 1131 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
       844        854        864        874 
afedrdptQF EERHLKFLQQ LGKgnfGSVE MCRYDPLQDN 
       884        894        904        914 
TGEVVAVKKL qhsteeHLRD FEREIEILKS LQHDNIVKYK 
       924        934        944        954 
GVCysagrrn LKLIMEYLPY GSLRDYLQAH AERIDHIKLL 
       964        974        984        994 
QYTSQICKGM EYLGTKRYIH RDLATRNILV ENENRVKIGD 
      1004       1014       1024       1034 
FGLTKVLPQD KEYYKVKEPG ESPIFWYAPE SLTESKFSVA 
      1044       1054       1064       1074 
SDVWSFGVVL YELFTYIEKS KSPPAEFMRM IGNDKQGQMI 
      1084       1094       1104       1114 
VFHLIELLKN NGRLPRPDGC PDEIYMIMTE CWNNNVNQRP 
      1124 
SFRDLALRVD QIRDQMAg
Lower-case residues are disordered in structure.
Mutations: K943A,K945A
Phosphorylation: X1007,X1008