5UT5

JAK2 (Tyrosine-protein kinase JAK2)
Pseudokinase
Group: TYR
Uniprot: JAK2_HUMAN
Organism: Homo sapiens
Domain boundary: 545 - 809
Resolu: 1.9

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin None in-none out-out 2HB Type1 537 - 808 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
       545        555        565        575 
vFHKIRNEDL IFNESLGQGT FTKIFKGVRR EVGDYGQLHE 
       585        595        605        615 
TEVLLKVLDK AHRNYSESFF EAASMMSKLS HKHLVLNYGV 
       625        635        645        655 
CVCGDENILV QEFVKFGSLD TYLKKNKNCI NILWKLEVAK 
       665        675        685        695 
QLAAAMHFLE ENTLIHGNVC AKNILLIREE DRKTGNPPFI 
       705        715        725        735 
KLSDPGISIT VLPKDILQER IPWVPPECIE NPKNLNLATD 
       745        755        765        775 
KWSFGTTLWE ICSGGDKPLS ALDSQRKLQF YEDRHQLPAP 
       785        795        805          - 
KAAELANLIN NCMDYEPDHR PSFRAIIRDL NSLftpdlvp 

rgshhhhhh
Lower-case residues are disordered in structure.
Mutations: W659A,W777A,F794H
Phosphorylation: None