3FUP

JAK2 (Tyrosine-protein kinase JAK2)
Group: TYR
Uniprot: JAK2_HUMAN
Organism: Homo sapiens
Domain boundary: 849 - 1124
Resolu: 2.4

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin ABAminus in-in in-in MI1 Type1 843 - 1132 0
B Inactive DFGin ABAminus in-in in-in MI1 Type1 840 - 1132 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
       849        859        869        879 
DPTQFEERHL KFLQQLGKGN FGSVEMCRYD PLQDNTGEVV 
       889        899        909        919 
AVKKLQHSTE EHLRDFEREI EILKSLQHDN IVKYKGVCYS 
       929        939        949        959 
agrrNLKLIM EYLPYGSLRD YLQKHKERID HIKLLQYTSQ 
       969        979        989        999 
ICKGMEYLGT KRYIHRDLAT RNILVENENR VKIGDFGLTK 
      1009       1019       1029       1039 
VLPQDKEYYK VKEPGESPIF WYAPESLTES KFSVASDVWS 
      1049       1059       1069       1079 
FGVVLYELFT YIEKSKSPPA EFMRMIGNDK QGQMIVFHLI 
      1089       1099       1109       1119 
ELLKNNGRLP RPDGCPDEIY MIMTECWNNN VNQRPSFRDL 
      1129 
ALRVDQIRDQ MAG
Lower-case residues are disordered in structure.
Mutations: N1129Q
Phosphorylation: X1007,X1008