Protein kinases in complex with IZA

Total number of genes: 5
Total number of chains: 8
Spatial Dihedral Chains Representative
DFGin BLAminus 5 3LXPA
DFGin ABAminus 3 2B7AA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
CAMK DAPK3 DAPK3_HUMAN Death-associated protein kinase 3 2J90A 2.0 Inactive DFGin BLAminus in-in in-out IZA Type1
CAMK DAPK3 DAPK3_HUMAN Death-associated protein kinase 3 2J90B 2.0 Inactive DFGin BLAminus in-in in-out IZA Type1
TYR JAK1 JAK1_HUMAN Tyrosine-protein kinase JAK1 3EYHA 2.0 Inactive DFGin ABAminus in-in in-in IZA Type1
TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 2B7AA 2.0 Inactive DFGin ABAminus in-in in-in IZA Type1
TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 2B7AB 2.0 Inactive DFGin ABAminus in-in in-in IZA Type1
TYR JAK3 JAK3_HUMAN Tyrosine-protein kinase JAK3 3LXLA 1.74 Active DFGin BLAminus in-in in-in IZA Type1
TYR TYK2 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 3LXPA 1.65 Active DFGin BLAminus in-in in-in IZA Type1
TYR TYK2 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 3NZ0A 2.0 Active DFGin BLAminus in-in in-in IZA Type1

Protein kinases in complex with IZA

Total number of genes: 6
Total number of chains: 14
Spatial Dihedral Chains Representative
DFGin BLAminus 9 3LXPA
DFGin ABAminus 5 2B7AA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens CAMK DAPK3 DAPK3_HUMAN Death-associated protein kinase 3 2J90A 2.0 Inactive DFGin BLAminus in-in in-out IZA Type1
Homo sapiens CAMK DAPK3 DAPK3_HUMAN Death-associated protein kinase 3 2J90B 2.0 Inactive DFGin BLAminus in-in in-out IZA Type1
Homo sapiens TYR JAK1 JAK1_HUMAN Tyrosine-protein kinase JAK1 3EYHA 2.0 Inactive DFGin ABAminus in-in in-in IZA Type1
Homo sapiens TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 2B7AA 2.0 Inactive DFGin ABAminus in-in in-in IZA Type1
Homo sapiens TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 2B7AB 2.0 Inactive DFGin ABAminus in-in in-in IZA Type1
Homo sapiens TYR JAK3 JAK3_HUMAN Tyrosine-protein kinase JAK3 3LXLA 1.74 Active DFGin BLAminus in-in in-in IZA Type1
Homo sapiens TYR TYK2 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 3LXPA 1.65 Active DFGin BLAminus in-in in-in IZA Type1
Homo sapiens TYR TYK2 TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 3NZ0A 2.0 Active DFGin BLAminus in-in in-in IZA Type1
Mus musculus TYR JAK2 JAK2_MOUSE Tyrosine-protein kinase JAK2 4GL9A 3.9 Inactive DFGin BLAminus in-in in-out IZA Type1
Mus musculus TYR JAK2 JAK2_MOUSE Tyrosine-protein kinase JAK2 4GL9B 3.9 Inactive DFGin BLAminus in-in in-out IZA Type1
Mus musculus TYR JAK2 JAK2_MOUSE Tyrosine-protein kinase JAK2 4GL9C 3.9 Inactive DFGin BLAminus in-in in-out IZA Type1
Mus musculus TYR JAK2 JAK2_MOUSE Tyrosine-protein kinase JAK2 4GL9D 3.9 Active DFGin BLAminus in-in in-in IZA Type1
Saccharomyces cerevisiae OTHER IRE1 IRE1_YEAST Serine/threonine-protein kinase/endoribonuclease IRE1 3LJ2A 3.33 Inactive DFGin ABAminus in-in in-none IZA Type1
Saccharomyces cerevisiae OTHER IRE1 IRE1_YEAST Serine/threonine-protein kinase/endoribonuclease IRE1 3LJ2B 3.33 Inactive DFGin ABAminus in-in in-none IZA Type1

Protein kinases in complex with IZA

Total number of genes: 2
Total number of chains: 6
Spatial Dihedral Chains Representative
DFGin BLAminus 4 4GL9A
DFGin ABAminus 2 3LJ2A
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Mus musculus TYR JAK2 JAK2_MOUSE Tyrosine-protein kinase JAK2 4GL9A 3.9 Inactive DFGin BLAminus in-in in-out IZA Type1
Mus musculus TYR JAK2 JAK2_MOUSE Tyrosine-protein kinase JAK2 4GL9B 3.9 Inactive DFGin BLAminus in-in in-out IZA Type1
Mus musculus TYR JAK2 JAK2_MOUSE Tyrosine-protein kinase JAK2 4GL9C 3.9 Inactive DFGin BLAminus in-in in-out IZA Type1
Mus musculus TYR JAK2 JAK2_MOUSE Tyrosine-protein kinase JAK2 4GL9D 3.9 Active DFGin BLAminus in-in in-in IZA Type1
Saccharomyces cerevisiae OTHER IRE1 IRE1_YEAST Serine/threonine-protein kinase/endoribonuclease IRE1 3LJ2A 3.33 Inactive DFGin ABAminus in-in in-none IZA Type1
Saccharomyces cerevisiae OTHER IRE1 IRE1_YEAST Serine/threonine-protein kinase/endoribonuclease IRE1 3LJ2B 3.33 Inactive DFGin ABAminus in-in in-none IZA Type1