5TQ3

JAK2 (Tyrosine-protein kinase JAK2)
Group: TYR
Uniprot: JAK2_HUMAN
Organism: Homo sapiens
Domain boundary: 849 - 1124
Resolu: 2.69

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin None in-in in-in 7GZ Type1.5_Back 843 - 1132 0
B Inactive DFGin None in-in in-in 7GZ Type1.5_Back 843 - 1132 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
       838        848        858        868 
mghhhhhhed rdptQFEERH LKFLQQLGKG NFGSVEMCRY 
       878        888        898        908 
DPLQDNTGEV VAVKKLQHST EEHLRDFERE IEILKSLQHD 
       918        928        938        948 
NIVKYKGVCY SAGRRNLKLI MEYLPYGSLR DYLQKHKERI 
       958        968        978        988 
DHIKLLQYTS QICKGMEYLG TKRYIHRDLA TRNILVENEN 
       998       1008       1018       1028 
RVKIGDFGLT KVLPQDKEYY KVKEPGESPI FWYAPESLTE 
      1038       1048       1058       1068 
SKFSVASDVW SFGVVLYELF TYIEKSKSPP AEFMRMIGNd 
      1078       1088       1098       1108 
kqGQSIVTHL IELLKNNGRL PRPDGCPDEI YMIMTECWNN 
      1118       1128 
NVNQRPSFRD LALRVDQVRD NMAG
Lower-case residues are disordered in structure.
Mutations: M1073S,F1076T,I1126V
Phosphorylation: X1007,X1008