5I4N

JAK2 (Tyrosine-protein kinase JAK2)
Pseudokinase
Group: TYR
Uniprot: JAK2_HUMAN
Organism: Homo sapiens
Domain boundary: 545 - 809
Resolu: 1.54

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin None out-none out-out ATP Type1 537 - 809 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
       544        554        564        574 
mvFHKIRNED LIFNESLGQG TFTKIFKGVR REVGDYGQLH 
       584        594        604        614 
ETEVLLKVLD KAHRNYSESF FAAASMMSKL SHKHLVLNYG 
       624        634        644        654 
VCFCGDENIL VQEFVKFGSL DTYLKKNKNC INILWKLEVA 
       664        674        684        694 
KQLAAAMHFL EENTLIHGNV CAKNILLIRE EDRKTGNPPF 
       704        714        724        734 
IKLSDPGISI TVLPKDILQE RIPWVPPECI ENPKNLNLAT 
       744        754        764        774 
DKWSFGTTLW EICSGGDKPL SALDSQRKLQ FYEDRHQLPA 
       784        794        804          - 
PKAAELANLI NNCMDYEPDH RPSFRAIIRD LNSLFtpdlv 
         - 
prgsHHhhhh
Lower-case residues are disordered in structure.
Mutations: E596A,V617F,W659A,W777A,F794H
Phosphorylation: None