7Q7W

JAK2 (Tyrosine-protein kinase JAK2)
Group: TYR
Uniprot: JAK2_HUMAN
Organism: Homo sapiens
Domain boundary: 849 - 1124
Resolu: 1.85

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in 9HR Type1.5_Back 840 - 1131 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
         -          -        846        856 
mhhhhhhdyk ddddkenlyf qgrDPTQFEE RHLKFLQQLG 
       866        876        886        896 
KGNFGSVEMC RYDPLQDNTG EVVAVKKLQH STEEHLRDFE 
       906        916        926        936 
REIEILKSLQ HDNIVKYKGV CYSAGRRNLK LIMEYLPYGS 
       946        956        966        976 
LRDYLQKHKE RIDHIKLLQY TSQICKGMEY LGTKRYIHRD 
       986        996       1006       1016 
LATRNILVEN ENRVKIGDFG LTKVLPQDKE YYKVKEPGES 
      1026       1036       1046       1056 
PIFWYAPESL TESKFSVASD VWSFGVVLYE LFTYIEKSKS 
      1066       1076       1086       1096 
PPAEFMRMIG NDKQGQSIVT HLIELLKNNG RLPRPDGCPD 
      1106       1116       1126 
EIYMIMTECW NNNVNQRPSF RDLALRVDQI RDNMAg
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X1007,X1008