4HGE

JAK2 (Tyrosine-protein kinase JAK2)
Group: TYR
Uniprot: JAK2_HUMAN
Organism: Homo sapiens
Domain boundary: 849 - 1124
Resolu: 2.3

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin ABAminus in-in in-in 15V Type1 843 - 1132 0
B Inactive DFGin ABAminus in-in in-in 15V Type1 839 - 1132 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
       842        852        862        872 
sgafedRDPT QFEERHLKFL QQLGKGNFGS VEMCRYDPLQ 
       882        892        902        912 
DNTGEVVAVK KLQHSTEEHL RDFEREIEIL KSLQHDNIVK 
       922        932        942        952 
YKGVCYSagr rNLKLIMEYL PYGSLRDYLQ KHKERIDHIK 
       962        972        982        992 
LLQYTSQICK GMEYLGTKRY IHRDLATRNI LVENENRVKI 
      1002       1012       1022       1032 
GDFGLTKVLP QDKEYYKVKE PGESPIFWYA PESLTESKFS 
      1042       1052       1062       1072 
VASDVWSFGV VLYELFTYIE KSKSPPAEFM RMIGNDKQGQ 
      1082       1092       1102       1112 
MIVFHLIELL KNNGRLPRPD GCPDEIYMIM TECWNNNVNQ 
      1122       1132 
RPSFRDLALR VDQIRDNMAG
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X1007,X1008