6G3C

JAK2 (Tyrosine-protein kinase JAK2)
Pseudokinase
Group: TYR
Uniprot: JAK2_HUMAN
Organism: Homo sapiens
Domain boundary: 545 - 809
Resolu: 1.6

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin None in-none out-out EKT Type1 537 - 808 0
B Inactive DFGin None in-none out-out EKT Type1 537 - 808 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
       546        556        566        576 
FHKIRNEDLI FNESLGQGTF TKIFKGVRRE VGDYGQLHET 
       586        596        606        616 
EVLLKVLDKA HRNYSESFFE AASMMSKLSH KHLVLNYGVC 
       626        636        646        656 
fcgdENILVQ EFVKFGSLDT YLKKNKNCIN ILWKLEVAKQ 
       666        676        686        696 
LAAAMHFLEE NTLIHGNVCA KNILLIREED RKTGNPPFIK 
       706        716        726        736 
LSDPGISITV LPKDILQERI PWVPPECIEN PKNLNLATDK 
       746        756        766        776 
WSFGTTLWEI CSGGDKPLSA LDSQRKLQFY EDRHQLPAPK 
       786        796        806 
AAELANLINN CMDYEPDHRP SFRAIIRDLN SL
Lower-case residues are disordered in structure.
Mutations: W659A,W777A,F794H
Phosphorylation: None