Ligand: 1M3

Total number of chains: 6
Spatial label Dihedral label Number of Chains Representative
DFGin ABAminus 6 5HEZB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR JAK2 JAK2_HUMAN 5HEZ 2.66 Inactive DFGin‑ABAminus in-in in-out 1M3, 1M3 Allosteric, Type1 842 - 1132 0 X1007,X1008 P1057A Tyrosine-protein kinase JAK2
TYR JAK2 JAK2_HUMAN 5HEZ 2.66 Inactive DFGin‑ABAminus in-in in-out 1M3, 1M3 Allosteric, Type1 842 - 1132 0 X1007,X1008 P1057A Tyrosine-protein kinase JAK2
TYR JAK2 JAK2_HUMAN 5HEZ 2.66 Inactive DFGin‑ABAminus in-in in-out 1M3, 1M3 Allosteric, Type1 842 - 1132 0 X1007,X1008 P1057A Tyrosine-protein kinase JAK2
TYR JAK2 JAK2_HUMAN 4JI9 2.4 Inactive DFGin‑ABAminus in-in in-out 1M3 Type1 843 - 1132 0 X1007,X1008 None Tyrosine-protein kinase JAK2
TYR JAK2 JAK2_HUMAN 4JI9 2.4 Inactive DFGin‑ABAminus in-in in-in 1M3 Type1 839 - 1132 0 X1007,X1008 None Tyrosine-protein kinase JAK2
TYR JAK2 JAK2_HUMAN 5HEZ 2.66 Inactive DFGin‑ABAminus in-in in-out 1M3, 1M3 Type1, Allosteric 842 - 1132 0 X1007,X1008 P1057A Tyrosine-protein kinase JAK2

Ligand: 1M3

Total number of chains: 6
Spatial label Dihedral label Number of Chains Representative
DFGin ABAminus 6 5HEZB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR JAK2 JAK2_HUMAN 5HEZ 2.66 Inactive DFGin‑ABAminus in-in in-out 1M3, 1M3 Allosteric, Type1 842 - 1132 0 X1007,X1008 P1057A Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2 JAK2_HUMAN 5HEZ 2.66 Inactive DFGin‑ABAminus in-in in-out 1M3, 1M3 Allosteric, Type1 842 - 1132 0 X1007,X1008 P1057A Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2 JAK2_HUMAN 5HEZ 2.66 Inactive DFGin‑ABAminus in-in in-out 1M3, 1M3 Allosteric, Type1 842 - 1132 0 X1007,X1008 P1057A Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2 JAK2_HUMAN 4JI9 2.4 Inactive DFGin‑ABAminus in-in in-out 1M3 Type1 843 - 1132 0 X1007,X1008 None Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2 JAK2_HUMAN 4JI9 2.4 Inactive DFGin‑ABAminus in-in in-in 1M3 Type1 839 - 1132 0 X1007,X1008 None Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2 JAK2_HUMAN 5HEZ 2.66 Inactive DFGin‑ABAminus in-in in-out 1M3, 1M3 Type1, Allosteric 842 - 1132 0 X1007,X1008 P1057A Tyrosine-protein kinase JAK2 Homo sapiens

Ligand: 1M3

Total number of chains: 0
Spatial label Dihedral label Number of Chains Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism