8G8O

JAK2 (Tyrosine-protein kinase JAK2)
Group: TYR
Uniprot: JAK2_HUMAN
Organism: Homo sapiens
Domain boundary: 849 - 1124
Resolu: 2.2

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin ABAminus in-in in-in YT0 Type1 842 - 1130 0
B Inactive DFGin ABAminus in-in in-in YT0 Type1 843 - 1130 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
         -          -        844        854 
mhhhhhhtsl ykkagflvpr gsedrdptQF EERHLKFLQQ 
       864        874        884        894 
LGKGNFGSVE MCRYDPLQDN TGEVVAVKKL QHSTEEHLRD 
       904        914        924        934 
FEREIEILKS LQHDNIVKYK GVCYSagRRN LKLIMEYLPY 
       944        954        964        974 
GSLRDYLQKH KERIDHIKLL QYTSQICKGM EYLGTKRYIH 
       984        994       1004       1014 
RDLATRNILV ENENRVKIGD FGLTKVLPQD KEYYKVKepg 
      1024       1034       1044       1054 
ESPIFWYAPE SLTESKFSVA SDVWSFGVVL YELFTYIEKS 
      1064       1074       1084       1094 
KSPPAEFMRM IGndkqGQSI VTHLIELLKN NGRLPRPDGC 
      1104       1114       1124 
PDEIYMIMTE CWNNNVNQRP SFRDLALRVD QIRDNMag
Lower-case residues are disordered in structure.
Mutations: M1073S,F1076T
Phosphorylation: X1007,X1008