Phylogeny of Human Protein Kinase Domains
We provide the phylogenetic tree of 496 human protein kinases created by using our accurate structure-based multiple sequence alignment. The tree was generated using the program MegaX with neighbour joining algorithm. Using the tree we have categorized 10 kinases comprising the Aurora kinases, Polo kinases, and calcium/calmodulin-dependent kinase kinases into CAMK group. These kinases were previously identified as OTHER.
The following table provides the number of human protein kinases in each group.
| AGC | CAMK | CK1 | CMGC | NEK | RGC | STE | TKL | TYR | OTHER | Total | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Genes | 62 | 88 | 12 | 65 | 11 | 5 | 47 | 42 | 90 | 66 | 484* |
| Domains | 62 | 92 | 12 | 65 | 11 | 5 | 47 | 42 | 94 | 67 | 497 |
*6 kinase genes have one AGC and one CAMK domain each (RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5 and RPS6KA6), and are counted twice in this table; 2 kinases have 2 CAMK domains (OBSCN, SPEG); 4 kinases have 2 TYR domains (JAK1, JAK2, JAK3, TYK2); 1 kinase has 2 domains in the OTHER category (EIF2AK4) (484 + 6 + 2 + 4 + 1 = 497 domains). Two kinases, AGC_PDPK2P and AGC_PRKY, could be pseudogenes according to their Uniprot annotations.
The phylogenetic tree could be visualized on iTOL server or downloaded as a text file:
