8JN8

SRC (Proto-oncogene tyrosine-protein kinase Src)
Group: TYR
Uniprot: SRC_HUMAN
Organism: Homo sapiens
Domain boundary: 270 - 521
Resolu: 1.902

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLBplus out-out out-out JA6 Allosteric 86 - 536 0
Representative sequence - Chain A
10 20 30 40
mgsnkskpkd asqrrrslep aenvhgaggg afpasqtpsk
50 60 70 80
pasadghrgp saafapaaae pklfggfnss dtvtspqrag
90 100 110 120
plaggVTTFV ALYDYESRTE TDLSFKKGER LQIVNNTEGD
130 140 150 160
WWLAHSLSTG QTGYIPSNYV APSDSIQAEE WYFGKITRRE
170 180 190 200
SERLLLNAEN PRGTFLVRES ETTKGAYCLS VSDFDNAKGL
210 220 230 240
NVKHYKIRKL DSGGFYITSR TQFNSLQQLV AYYSKHADGL
250 260 270 280
CHRLTTVCPT SKPQTQGLAK DAWEIPRESL RLEVKLGQGC
290 300 310 320
FGEVWMGTWN GTTRVAIKTL KPGTMSPEAF LQEAQVMKKL
330 340 350 360
RHEKLVQLYA VVSEEPIYIV TEYMSKGSLL DFLKGETGKY
370 380 390 400
LRLPQLVDMA AQIASGMAYV ERMNYVHRDL RAANILVGEN
410 420 430 440
LVCKVADFGL ARLIEDNEYT ARQGAKFPIK WTAPEAALYG
450 460 470 480
RFTIKSDVWS FGILLTELTT KGRVPYPGMV NREVLDQVER
490 500 510 520
GYRMPCPPEC PESLHDLMCQ CWRKEPEERP TFEYLQAFLE
530
DYFTSTEPQY QPGENL
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X530