6V6Q

FGFR2 (Fibroblast growth factor receptor 2)
Group: TYR
Uniprot: FGFR2_HUMAN
Organism: Homo sapiens
Domain boundary: 481 - 759
Resolu: 2.46

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in ACP Type1 466 - 765 0
B Active DFGin BLAminus in-in in-in ACP Type1 467 - 766 0
C Inactive DFGin BLBminus in-in in-in ACP Type1 467 - 766 11
D Active DFGin BLAminus in-in in-in ACP Type1 467 - 765 9
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain D
       420        430        440        450 
gspavhkltk riplrrqvtv saessssmns ntplvrittr 
       460        470        480        490 
lsstadtpml agvsefELPE DPKWEFPRDK LTLGKPLGEG 
       500        510        520        530 
CFGQVVMAEA VGIDKDKPKE AVTVAVKMLK DDATEKDLSD 
       540        550        560        570 
LVSEMEMMKM IGKHKNIINL LGACTQDGPL FVIVEFASKG 
       580        590        600        610 
NLREFLRARR PPgmefsfdi nrvpeeQMTF KDLVSCTFQL 
       620        630        640        650 
ARGMEFLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD 
       660        670        680        690 
INNidyfkkt tnGRLPVKWM APEALFDRVY THQSDVWSFG 
       700        710        720        730 
VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH RMDKPANCTN 
       740        750        760        770 
ELFMMMRDCW HAVPSQRPTF KQLVEDLDRI LTLTTneeyl 
       780        790        800        810 
dlsqpleqys psypdtrssc ssgddsvfsp dpmpyepclp 
       820 
qyphingsvk t
Lower-case residues are disordered in structure.
Mutations: Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F
Phosphorylation: X656