Ligand: ACP

Total number of chains: 91
Active chains: 10
Total number of genes: 19
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 63 69.2% 5UI0B
DFGin BLBplus 10 11.0% 4ANBA
DFGin ABAminus 6 6.6% 6EQ9A
DFGin BLBminus 5 5.5% 7KJCA
DFGin BLAplus 2 2.2% 6PNXB
DFGin None 2 2.2% 4C3PA
DFGinter None 2 2.2% 4C3RA
None None 1 1.1% 6C83A
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC PRKCI KPCI_HUMAN 5LI9A P41743 248 589 596.0 ACP:60601 ATPlike Active DFGin 5.635 12.633 BLAminus -139.17, 172.4 72.31, 78.11 -98.86, 1.23 304.03, 143.26 -64.9, -22.84 in-in in 8.361 Saltbr-in 2.614 HRD-in -73.79, -55.22 70.11, -1.11 in-in-in SNCiii in-in ActLoopNT-in 2.81 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.64, 169.55 APE9-dihe-na 127.72, -178.47 APE8-dihe-in -93.25, 127.56 APE8-rot-in 298.81 APE67-dihe-in -60.64, -20.02 -47.28, -45.36 APE12-dist-in 8.812 APE11-dist-in 11.949 APE10-dist-in 6.432 APE9-dist-in 3.836 None TPO412,TPO564 TPO412,TPO564 XRAY 1.79 0.19 0.231 A 350 330 12 0 0 0 [[254, 522]] 1.0 5li9 AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC RPS6KA1-1 KS6A1_HUMAN 2Z7QA Q15418 56 340 735.0 ACP:500 ATPlike Inactive DFGin 8.028 12.369 BLBplus -135.49, 158.95 63.12, 60.24 -125.42, -165.59 47.01, 74.46 107.04, -8.15 none-none none 999.0 Saltbr-none 999.0 HRD-out -82.53, 70.19 -54.28, -43.87 none-out-out SNCnoo out-out ActLoopNT-out 7.053 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -165.36 APE8-dihe-in -67.18, 106.47 APE8-rot-in 305.06 APE67-dihe-in -59.78, -23.27 -56.13, -39.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.791 None None None XRAY 2.0 0.264 0.283 A 321 255 30 0 0 12 [[62, 321], [418, 675]] 2.0 2z7q AGC_RPS6KA1-1_HUMAN AGC 1.5e-95 325.1 1 260 260 204 205 206 208 210 94 112 116 184 186 185 187 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
CAMK AURKA AURKA_HUMAN 4C3PD O14965 125 390 403.0 ACP:1391 ATPlike Inactive DFGin 5.08 15.091 ABAminus -119.78, -23.96 -110.92, 146.31 -144.29, 22.56 288.75, 97.88 -63.46, -34.21 out-out out 11.164 Saltbr-out 5.973 HRD-out -75.78, -41.12 71.55, -101.13 out-in-out SNCoio in-out ActLoopNT-in 3.111 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -140.51, -146.18 APE9-dihe-na 83.68, 6.59 APE8-dihe-out -140.3, 13.24 APE8-rot-out 207.12 APE67-dihe-in -44.87, -30.51 -70.19, -27.98 APE12-dist-none 999.0 APE11-dist-out 20.87 APE10-dist-out 24.129 APE9-dist-out 28.582 None None None XRAY 2.69 0.205 0.289 D 282 260 6 0 0 6 [[133, 383]] 1.0 4c3p CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5G15A O14965 126 390 403.0 ACP:1391 ATPlike Inactive DFGin 5.983 16.386 BLAminus -138.69, -169.03 59.87, 67.73 -86.51, 18.94 284.94, 72.05 -48.14, -38.59 out-out out 10.296 Saltbr-out 5.173 HRD-in -73.28, -52.04 69.95, 14.4 out-in-in SNCoii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.64, 165.4 APE9-dihe-na 125.58, -148.7 APE8-dihe-in -133.46, 135.34 APE8-rot-in 292.83 APE67-dihe-in -71.67, -13.58 -36.11, -59.51 APE12-dist-in 10.319 APE11-dist-in 11.183 APE10-dist-in 5.61 APE9-dist-in 3.463 None None None XRAY 2.06 0.229 0.274 A 282 265 0 0 0 0 [[133, 383]] 1.0 5g15 CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6CPFA O14965 128 392 403.0 ACP:501 ATPlike Inactive DFGin 5.851 16.076 BLAminus -125.44, -173.01 51.86, 75.65 -92.36, 20.23 261.59, 77.98 -63.75, -18.06 out-none out 11.248 Saltbr-none 999.0 HRD-in -104.84, -51.34 76.83, -36.49 none-in-out SNCnio in-out ActLoopNT-in 3.202 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -168.9 APE8-dihe-in -78.28, 136.09 APE8-rot-out 59.9 APE67-dihe-in -54.01, -29.69 -75.21, 5.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.708 None None None XRAY 2.3 0.222 0.259 A 285 259 6 0 0 6 [[133, 383]] 1.0 6cpf CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4C3PA O14965 125 388 403.0 ACP:1389 ATPlike Inactive DFGin 5.121 15.311 None -143.16, 44.14 -117.33, -72.7 63.16, 22.36 309.54, 103.5 -71.05, -27.42 out-out out 10.713 Saltbr-out 4.955 HRD-out -79.39, 150.41 -121.39, -68.05 out-in-out SNCoio in-out ActLoopNT-in 2.819 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -49.34, 122.38 APE9-dihe-na 116.03, -35.9 APE8-dihe-out -100.65, -0.54 APE8-rot-out 177.69 APE67-dihe-in -57.5, -32.82 -45.19, -41.29 APE12-dist-out 20.928 APE11-dist-out 21.176 APE10-dist-out 26.156 APE9-dist-out 28.591 None None None XRAY 2.69 0.205 0.289 A 282 264 0 0 0 0 [[133, 383]] 1.0 4c3p CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4C3RA O14965 127 388 403.0 ACP:1389 ATPlike Inactive DFGinter 6.087 8.639 None -114.31, -7.36 -87.64, 130.6 -72.8, -47.16 285.43, 29.08 69.28, 138.63 out-out out 11.963 Saltbr-out 7.785 HRD-out -148.79, 112.09 -68.12, -80.01 out-out-out SNCooo out-out ActLoopNT-out 8.017 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 137.49 APE8-dihe-in -74.84, 138.8 APE8-rot-out 199.32 APE67-dihe-in -50.64, -36.72 -89.13, -8.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.231 None None None XRAY 2.79 0.229 0.306 A 282 252 10 0 0 10 [[133, 383]] 1.0 4c3r CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6C83B O14965 127 388 403.0 ACP:501 ATPlike Inactive DFGinter 7.317 8.588 None -129.69, 90.85 -100.04, 101.37 -135.34, 999.0 303.1, 99.49 999.0, 999.0 out-out out 12.115 Saltbr-out 10.049 HRD-out -96.09, 116.19 -110.78, 111.97 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -90.23 APE8-dihe-out -77.58, -0.58 APE8-rot-out 85.03 APE67-dihe-in -69.49, -5.14 -61.84, -44.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.472 None None None XRAY 2.55 0.268 0.322 B 285 247 15 0 0 15 [[133, 383]] 1.0 6c83 CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6C83A O14965 127 389 403.0 ACP:501 ATPlike Inactive None 999.0 999.0 None -115.58, 146.0 -134.74, 164.64 -155.95, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.294 Saltbr-none 999.0 HRD-out 57.31, 86.65 -118.52, 133.44 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -76.52 APE8-dihe-out -81.29, 5.34 APE8-rot-out 166.86 APE67-dihe-in -68.45, -16.44 -75.67, -23.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.256 None None None XRAY 2.55 0.268 0.322 A 285 248 15 0 0 15 [[133, 383]] 1.0 6c83 CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK DAPK1 DAPK1_HUMAN 3ZXTB P53355 7 276 1430.0 ACP:1279 ATPlike None DFGin 6.575 14.067 BLAminus -121.46, -170.78 56.12, 80.76 -103.93, 17.27 282.46, 79.2 -56.39, -19.56 in-in in 8.68 Saltbr-in 2.544 HRD-in -82.72, -41.2 65.14, 3.07 in-in-none SNCiin in-none ActLoopNT-in 2.949 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -71.62 APE8-rot-none 999.0 APE67-dihe-in -62.85, -24.88 -49.25, -41.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 B 285 253 17 0 0 10 [[13, 275]] 1.0 3zxt CAMK_DAPK1_HUMAN CAMK 5.5e-95 323.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3ZXTC P53355 5 276 1430.0 ACP:1278 ATPlike None DFGin 6.764 14.238 BLAminus -125.03, -178.44 64.54, 79.35 -91.9, 24.57 287.83, 76.0 -66.08, -19.72 in-in in 9.392 Saltbr-in 2.719 HRD-in -72.23, -37.44 57.47, 4.52 in-in-none SNCiin in-none ActLoopNT-in 3.097 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -39.65, -42.12 999.0, -61.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 C 285 259 13 0 0 11 [[13, 275]] 1.0 3zxt CAMK_DAPK1_HUMAN CAMK 5.5e-95 323.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3ZXTD P53355 7 276 1430.0 ACP:1277 ATPlike None DFGin 6.866 14.645 BLAminus -115.85, 173.32 73.06, 78.3 -92.76, 17.5 283.87, 68.26 -68.46, 25.44 in-in in 9.306 Saltbr-in 2.651 HRD-in -83.16, -46.35 65.92, 13.4 in-in-none SNCiin in-none ActLoopNT-in 3.108 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -20.61 APE8-rot-none 999.0 APE67-dihe-in -90.53, -15.22 -91.11, -7.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 D 285 245 25 0 0 10 [[13, 275]] 1.0 3zxt CAMK_DAPK1_HUMAN CAMK 5.5e-95 323.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3ZXTA P53355 7 276 1430.0 ACP:1277 ATPlike Inactive DFGin 6.539 14.057 BLBminus -116.48, -174.8 63.15, 89.03 -105.65, -162.71 284.37, 74.81 49.59, 38.57 in-in in 8.914 Saltbr-in 3.208 HRD-in -74.82, -48.06 69.59, 6.45 in-in-none SNCiin in-none ActLoopNT-in 2.725 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -35.07 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 A 285 249 21 0 0 12 [[13, 275]] 1.0 3zxt CAMK_DAPK1_HUMAN CAMK 5.5e-95 323.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CK1 CSNK1D KC1D_HUMAN 6RU6A P48730 3 294 415.0 ACP:60301 ATPlike Active DFGin 6.436 15.264 BLAminus -136.56, 176.84 69.53, 73.53 -93.66, 24.95 289.84, 81.36 -61.77, -30.96 in-in in 7.923 Saltbr-in 2.789 HRD-in -77.83, -55.12 76.08, 12.52 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.64, 119.59 APE9-dihe-na 102.6, -136.74 APE8-dihe-in -117.46, 127.27 APE8-rot-in 311.09 APE67-dihe-in -57.82, -37.85 -53.66, -47.41 APE12-dist-in 12.315 APE11-dist-in 11.908 APE10-dist-in 6.481 APE9-dist-in 3.505 None None None XRAY 2.05 0.213 0.257 A 296 288 4 0 0 0 [[9, 275]] 1.0 6ru6 CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU6B P48730 3 294 415.0 ACP:60301 ATPlike None DFGin 6.59 15.156 BLAminus -129.63, 177.25 73.9, 71.28 -92.31, 21.27 283.76, 74.29 -58.84, -31.38 in-in in 7.818 Saltbr-in 2.796 HRD-in -76.32, -55.32 74.02, 14.82 in-in-none SNCiin in-none ActLoopNT-in 2.86 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -126.17 APE8-dihe-in -104.51, 127.76 APE8-rot-in 311.88 APE67-dihe-in -57.59, -35.09 -58.93, -44.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.941 None None None XRAY 2.05 0.213 0.257 B 296 278 14 0 0 8 [[9, 275]] 1.0 6ru6 CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CMGC CSNK2A1 CSK21_HUMAN 4NH1A P68400 3 332 391.0 ACP:403 ATPlike Inactive DFGin 7.539 16.051 BLAminus -114.39, -169.88 57.86, 83.41 -112.16, 31.33 299.65, 85.49 -75.44, -39.86 in-in in 9.278 Saltbr-in 2.773 HRD-in -89.66, -46.45 59.34, 26.3 in-in-out SNCiio in-out ActLoopNT-in 2.903 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.56, 170.73 APE9-dihe-na 63.23, 162.58 APE8-dihe-in -68.16, 150.73 APE8-rot-out 180.05 APE67-dihe-in -73.61, -11.12 -57.46, -41.94 APE12-dist-in 12.715 APE11-dist-in 10.529 APE10-dist-in 6.058 APE9-dist-in 3.323 None None None XRAY 3.3 0.215 0.251 A 335 330 0 0 0 0 [[39, 324]] 1.0 4nh1 CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 4NH1B P68400 2 333 391.0 ACP:404 ATPlike Inactive DFGin 7.534 16.001 BLAminus -114.45, -169.84 57.84, 82.99 -112.41, 30.84 300.31, 85.61 -75.38, -39.92 in-in in 9.231 Saltbr-in 2.774 HRD-in -90.12, -46.63 59.22, 26.59 in-in-out SNCiio in-out ActLoopNT-in 2.954 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.21, 170.34 APE9-dihe-na 63.1, 162.47 APE8-dihe-in -68.11, 151.28 APE8-rot-out 180.18 APE67-dihe-in -73.01, -10.91 -57.19, -42.14 APE12-dist-in 12.652 APE11-dist-in 10.528 APE10-dist-in 5.992 APE9-dist-in 3.365 None None None XRAY 3.3 0.215 0.251 B 335 332 0 0 0 0 [[39, 324]] 1.0 4nh1 CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC MAPK1 MK01_HUMAN 5V60A P28482 10 358 360.0 ACP:401 ATPlike Active DFGin 6.669 14.887 BLAminus -124.21, -175.27 60.56, 75.29 -91.11, 25.45 286.11, 68.09 -67.4, -23.76 in-in in 9.269 Saltbr-in 3.088 HRD-in -75.88, -52.24 69.24, 12.32 in-in-in SNCiii in-in ActLoopNT-in 2.951 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -89.66, 171.23 APE9-dihe-na 66.7, 168.41 APE8-dihe-in -89.68, 141.19 APE8-rot-in 301.48 APE67-dihe-in -66.12, -19.67 -43.41, -50.15 APE12-dist-in 12.574 APE11-dist-in 11.086 APE10-dist-in 6.633 APE9-dist-in 2.987 None TPO185,PTR187 TPO185,PTR187 XRAY 2.18 0.193 0.226 A 356 349 0 0 0 0 [[25, 313]] 1.0 5v60 CMGC_MAPK1_HUMAN CMGC 8.8e-86 293.8 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK10 MK10_HUMAN 6EQ9B P53779 47 400 464.0 ACP:502 ATPlike Inactive DFGin 3.849 14.536 ABAminus -85.08, -18.98 -157.51, 177.19 -105.91, 17.98 303.5, 84.3 71.4, -149.1 in-in in 9.644 Saltbr-in 2.882 HRD-in -75.97, -57.51 71.23, 0.13 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 107.58 APE8-dihe-in -64.66, 120.8 APE8-rot-in 307.67 APE67-dihe-in -65.89, -19.34 -114.84, 1.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.043 None None None XRAY 1.83 0.207 0.252 B 367 332 14 0 0 14 [[64, 359]] 1.0 6eq9 CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 6EQ9A P53779 46 400 464.0 ACP:505,C15:506 ATPlike,Allosteric Inactive DFGin 3.763 14.179 ABAminus -90.84, -25.71 -146.46, -174.02 -119.81, 8.04 305.39, 99.67 64.39, -162.69 in-out in 9.653 Saltbr-out 3.917 HRD-in -74.99, -56.85 72.96, -15.02 out-out-out SNCooo out-out ActLoopNT-out 6.285 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -45.37 APE8-dihe-in -112.64, 106.03 APE8-rot-in 290.72 APE67-dihe-in -70.8, -9.5 -110.9, 2.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.517 None None None XRAY 1.83 0.207 0.252 A 367 350 5 0 0 5 [[64, 359]] 1.0 6eq9 CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 8VTFA P53779 45 400 464.0 A1ACP:1101 Type1 Inactive DFGin 4.123 14.437 ABAminus -80.88, -55.79 -105.49, 178.52 -116.12, 4.6 292.24, 108.11 97.34, -165.3 out-out out 10.177 Saltbr-out 6.059 HRD-in -81.08, -68.87 73.64, -1.6 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -88.73, 154.5 APE9-dihe-na -85.68, 161.75 APE8-dihe-in -104.45, 122.83 APE8-rot-in 288.76 APE67-dihe-in -66.26, -13.42 -118.39, 6.09 APE12-dist-out 21.204 APE11-dist-out 17.128 APE10-dist-out 16.367 APE9-dist-out 11.624 None None None XRAY 2.4 0.258 0.297 A 464 346 5 0 0 5 [[64, 359]] 1.0 8vtf CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
OTHER RNASEL RN5A_HUMAN 4OAVB Q05823 24 717 741.0 ACP:801 ATPlike Pseudo DFGin 6.475 12.367 BLAminus -139.92, -178.5 65.74, 91.26 -114.98, 14.68 309.18, 101.1 -77.21, 3.69 in-in in 6.905 Saltbr-in 2.74 HRD-in -87.38, -45.25 69.13, -2.14 in-in-na SNCiia in-na ActLoopNT-in 3.06 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.56, 102.63 APE9-dihe-na -56.52, -19.13 APE8-dihe-na -66.25, -31.04 APE8-rot-na 198.81 APE67-dihe-na -66.21, -44.37 -71.69, -39.0 APE12-dist-na 15.293 APE11-dist-na 17.012 APE10-dist-na 15.02 APE9-dist-na 14.396 H672N None None XRAY 2.1 0.2 0.229 B 699 673 8 0 0 0 [[353, 594]] 1.0 4oav OTHER_RNASEL_HUMAN RNASEL 4.1e-136 459.9 1 242 242 502 503 504 506 508 392 404 408 482 484 483 485 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
OTHER RNASEL RN5A_HUMAN 4OAVD Q05823 26 719 741.0 ACP:1001 ATPlike Pseudo DFGin 6.559 12.405 BLAminus -138.71, -178.08 64.72, 95.25 -118.8, 14.99 306.98, 96.56 -77.32, 4.45 in-in in 6.904 Saltbr-in 2.919 HRD-in -73.82, -49.38 73.22, -2.68 in-in-na SNCiia in-na ActLoopNT-in 2.915 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.59, 112.49 APE9-dihe-na -62.01, -29.18 APE8-dihe-na -62.89, -32.55 APE8-rot-na 188.49 APE67-dihe-na -70.07, -38.9 -67.42, -39.34 APE12-dist-na 14.651 APE11-dist-na 16.869 APE10-dist-na 14.635 APE9-dist-na 14.352 H672N None None XRAY 2.1 0.2 0.229 D 699 674 7 0 0 0 [[353, 594]] 1.0 4oav OTHER_RNASEL_HUMAN RNASEL 4.1e-136 459.9 1 242 242 502 503 504 506 508 392 404 408 482 484 483 485 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
STE MAP2K1 MP2K1_HUMAN 6U2GA Q02750 43 383 393.0 ACP:901 ATPlike Inactive DFGin 5.808 13.841 BLBplus -143.7, 174.8 53.7, 47.78 -98.62, 156.52 46.78, 97.62 -76.59, 70.13 out-out out 15.374 Saltbr-out 14.869 HRD-in -83.28, -55.76 76.37, -10.26 out-out-out SNCooo out-out ActLoopNT-out 9.207 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -64.24, 146.48 APE9-dihe-na -101.23, -173.03 APE8-dihe-out -114.34, -9.62 APE8-rot-out 55.71 APE67-dihe-out -148.86, 141.69 -149.81, 176.75 APE12-dist-out 19.186 APE11-dist-out 17.982 APE10-dist-out 22.105 APE9-dist-out 13.0 None None None XRAY 2.886 0.231 0.276 A 394 309 32 0 0 0 [[68, 361]] 1.0 6u2g STE_MAP2K1_HUMAN STE 2.4e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNEA Q02750 63 379 393.0 ACP:901,573:903 ATPlike,Type1 Inactive DFGin 6.382 13.69 BLBplus -140.61, 176.72 54.72, 28.13 -81.46, 161.59 52.56, 86.0 -81.78, 73.09 out-out out 15.497 Saltbr-out 15.779 HRD-in -64.01, -56.53 90.31, -35.13 out-out-out SNCooo out-out ActLoopNT-out 9.29 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -73.66, 137.78 APE9-dihe-na -84.79, 178.97 APE8-dihe-out -113.02, -24.38 APE8-rot-out 49.94 APE67-dihe-out -153.46, 146.56 -142.39, -172.52 APE12-dist-out 17.192 APE11-dist-out 21.653 APE10-dist-out 23.798 APE9-dist-out 13.497 None None None XRAY 2.848 0.186 0.24 A 341 286 31 0 0 0 [[68, 361]] 1.0 4mne STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNED Q02750 66 382 393.0 ACP:901,573:903 ATPlike,Type1 Inactive DFGin 6.263 13.873 BLBplus -124.78, 174.1 56.33, 33.25 -88.39, 154.28 50.46, 89.74 -73.02, 74.09 out-out out 15.538 Saltbr-out 15.614 HRD-in -64.9, -49.38 74.62, -12.51 out-out-out SNCooo out-out ActLoopNT-out 9.043 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -65.65, 150.79 APE9-dihe-na -95.28, -163.25 APE8-dihe-out -122.75, -11.87 APE8-rot-out 68.42 APE67-dihe-out -159.06, 142.59 -161.08, -176.92 APE12-dist-out 17.403 APE11-dist-out 21.784 APE10-dist-out 23.852 APE9-dist-out 13.632 None None None XRAY 2.848 0.186 0.24 D 341 285 32 0 0 0 [[68, 361]] 1.0 4mne STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4AN9A Q02750 61 381 393.0 ACP:61382,2P7:61384 ATPlike,Type3 Inactive DFGin 6.311 13.752 BLBplus -147.68, 174.84 72.25, 33.73 -84.91, 163.57 42.25, 107.87 -96.68, 81.85 out-out out 15.688 Saltbr-out 15.109 HRD-in -67.38, -51.77 90.36, -23.63 out-out-out SNCooo out-out ActLoopNT-out 9.417 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_onoo APE10-dihe-na 999.0, 140.8 APE9-dihe-na -91.12, -166.68 APE8-dihe-in -63.03, 65.46 APE8-rot-in 350.49 APE67-dihe-in -61.1, -23.55 -42.53, -42.27 APE12-dist-out 17.626 APE11-dist-none 999.0 APE10-dist-out 19.703 APE9-dist-out 7.857 S218E,S222E,G328A None None XRAY 2.8 0.205 0.313 A 301 278 1 0 0 1 [[68, 361]] 1.0 4an9 STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNEE Q02750 62 379 393.0 ACP:901,573:903 ATPlike,Type3 Inactive DFGin 6.301 13.741 BLBplus -139.17, 176.14 61.58, 40.21 -96.23, 153.1 47.97, 96.35 -69.87, 64.71 out-out out 15.796 Saltbr-out 16.157 HRD-in -84.17, -39.22 69.48, -27.4 out-out-out SNCooo out-out ActLoopNT-out 9.277 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -76.04, 124.0 APE9-dihe-na -78.04, -178.79 APE8-dihe-out -111.0, -36.1 APE8-rot-out 69.56 APE67-dihe-out -140.43, 146.63 -132.48, 167.21 APE12-dist-out 17.663 APE11-dist-out 21.775 APE10-dist-out 24.237 APE9-dist-out 13.553 None None None XRAY 2.848 0.186 0.24 E 341 286 32 0 0 0 [[68, 361]] 1.0 4mne STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNEH Q02750 66 380 393.0 ACP:901,573:903,573:904 ATPlike,Type3,Allosteric Inactive DFGin 6.378 13.891 BLBplus -149.03, 175.24 52.75, 36.33 -93.4, 157.98 53.98, 84.28 -78.54, 56.84 out-out out 15.815 Saltbr-out 15.456 HRD-in -72.48, -51.28 80.05, -1.12 out-out-out SNCooo out-out ActLoopNT-out 9.111 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -63.87, 146.83 APE9-dihe-na -98.86, 164.39 APE8-dihe-out -71.61, -59.39 APE8-rot-in 294.12 APE67-dihe-out -156.42, 156.79 -128.0, -169.25 APE12-dist-out 17.747 APE11-dist-out 21.888 APE10-dist-out 24.157 APE9-dist-out 13.665 None None None XRAY 2.848 0.186 0.24 H 341 275 40 0 0 0 [[68, 361]] 1.0 4mne STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4AN2A Q02750 61 381 393.0 EUI:61382,ACP:61383 Type3,ATPlike Inactive DFGin 6.506 13.62 BLBplus -122.79, 178.99 56.84, 40.15 -92.39, 167.6 39.23, 93.66 -89.21, 72.99 out-out out 15.447 Saltbr-out 15.276 HRD-in -67.56, -54.42 79.08, -11.1 out-out-out SNCooo out-out ActLoopNT-out 9.035 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -98.27, 63.09 APE9-dihe-na -45.72, -71.67 APE8-dihe-in -89.8, 67.42 APE8-rot-out 5.41 APE67-dihe-in -66.45, -14.82 -49.39, -42.64 APE12-dist-out 17.474 APE11-dist-out 16.559 APE10-dist-out 17.03 APE9-dist-out 8.716 S218E,S222E,G328A None None XRAY 2.5 0.215 0.299 A 301 279 0 0 0 0 [[68, 361]] 1.0 4an2 STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4ANBA Q02750 61 381 393.0 YQY:60501,ACP:60502 Type3,ATPlike Inactive DFGin 6.358 13.393 BLBplus -107.54, 172.13 64.32, 39.17 -93.81, 160.33 38.34, 94.07 -83.38, 74.0 out-out out 15.224 Saltbr-out 14.817 HRD-in -75.33, -47.65 77.84, -16.31 out-out-out SNCooo out-out ActLoopNT-out 9.414 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -89.14, -39.83 APE9-dihe-na 89.67, -158.68 APE8-dihe-in -87.88, 72.09 APE8-rot-out 15.75 APE67-dihe-in -64.72, -18.82 -69.34, -22.58 APE12-dist-out 17.552 APE11-dist-out 16.893 APE10-dist-out 19.841 APE9-dist-out 8.65 S218E,S222E,G328A None None XRAY 2.2 0.23 0.296 A 301 279 0 0 0 0 [[68, 361]] 1.0 4anb STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
TKL BRAF BRAF_HUMAN 6U2GB P15056 451 722 766.0 ACP:901 ATPlike Inactive DFGin 6.15 13.909 BLBplus -127.14, -173.09 46.65, 53.2 -113.93, 152.92 52.73, 94.7 72.25, -152.99 out-out out 14.606 Saltbr-out 12.705 HRD-in -59.19, -53.53 76.48, -9.73 out-out-out SNCooo out-out ActLoopNT-out 9.495 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -146.07, 161.59 APE9-dihe-na 90.18, -141.72 APE8-dihe-in -101.38, 139.04 APE8-rot-out 180.97 APE67-dihe-in -60.58, -31.67 -70.85, -22.56 APE12-dist-out 15.336 APE11-dist-out 15.709 APE10-dist-out 13.592 APE9-dist-out 9.892 None None None XRAY 2.886 0.231 0.276 B 307 264 8 0 0 8 [[457, 716]] 1.0 6u2g TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL RIPK2 RIPK2_HUMAN 5NG0A O43353 6 300 540.0 ACP:1000 ATPlike Inactive DFGin 5.878 14.178 BLAminus -123.27, -179.27 62.78, 77.58 -93.4, 20.77 286.94, 75.81 -61.85, -28.6 in-in in 8.205 Saltbr-in 2.745 HRD-in -73.28, -52.62 66.02, 10.49 in-in-out SNCiio in-out ActLoopNT-in 2.847 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 157.46 APE8-dihe-in -72.18, 143.02 APE8-rot-out 185.7 APE67-dihe-in -65.61, -24.81 -104.28, 1.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8 L294F None None XRAY 2.0 0.171 0.191 A 304 274 21 0 0 15 [[18, 292]] 1.0 5ng0 TKL_RIPK2_HUMAN TKL 4.1e-73 252.1 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5NG0B O43353 5 299 540.0 ACP:401 ATPlike Inactive DFGin 5.887 14.177 BLAminus -123.03, -178.96 62.29, 77.78 -94.31, 21.44 286.41, 77.58 -63.12, -27.82 in-in in 8.16 Saltbr-in 2.756 HRD-in -74.08, -51.77 69.59, 3.54 in-in-out SNCiio in-out ActLoopNT-in 2.853 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -72.33, -175.56 APE9-dihe-na 154.16, -172.85 APE8-dihe-in -105.14, 130.27 APE8-rot-in 300.55 APE67-dihe-in -61.64, -28.91 -51.09, -46.77 APE12-dist-in 11.85 APE11-dist-out 7.402 APE10-dist-in 6.02 APE9-dist-in 3.342 L294F None None XRAY 2.0 0.171 0.191 B 304 282 13 0 0 10 [[18, 292]] 1.0 5ng0 TKL_RIPK2_HUMAN TKL 4.1e-73 252.1 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5AR3A O43353 6 310 540.0 ACP:1311 ATPlike Inactive DFGin 5.924 14.288 BLAminus -133.03, 175.56 72.21, 76.24 -97.68, 34.32 293.9, 86.68 -66.76, -37.47 in-in in 7.994 Saltbr-in 2.8 HRD-in -61.0, -40.82 51.84, 8.75 in-in-out SNCiio in-out ActLoopNT-in 2.841 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -117.65 APE9-dihe-na 164.28, -57.84 APE8-dihe-in -114.77, 107.38 APE8-rot-out 185.6 APE67-dihe-in -64.24, -32.65 -95.4, 6.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.709 APE9-dist-out 10.828 None None None XRAY 3.23 0.192 0.254 A 326 279 26 0 0 14 [[18, 292]] 1.0 5ar3 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5AR3B O43353 6 310 540.0 ACP:1311 ATPlike Inactive DFGin 5.87 14.418 BLAminus -128.31, 176.09 65.92, 78.1 -98.91, 35.33 294.64, 70.55 -68.55, -48.71 in-in in 8.021 Saltbr-in 2.88 HRD-in -65.19, -46.65 55.58, 8.54 in-in-out SNCiio in-out ActLoopNT-in 2.861 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.98 APE8-rot-out 49.06 APE67-dihe-in -39.82, -41.25 -97.08, -7.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.23 0.192 0.254 B 326 276 29 0 0 16 [[18, 292]] 1.0 5ar3 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TYR EPHA2 EPHA2_HUMAN 7KJAB P29317 590 965 976.0 ACP:61003 ATPlike None DFGin 5.95 15.319 BLAminus -132.83, -173.32 70.39, 83.56 -118.78, 24.56 302.85, 98.09 -89.22, 999.0 in-in in 8.607 Saltbr-in 3.165 HRD-in -76.56, -48.38 78.92, -16.95 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.75 APE8-rot-na 32.08 APE67-dihe-in -69.28, -11.58 -65.6, -29.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.19 0.217 B 390 349 22 0 0 20 [[613, 873]] 1.0 7kja TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 7KJCA P29317 590 976 976.0 ACP:61001 ATPlike Inactive DFGin 5.878 14.93 BLBminus -137.77, -170.41 70.81, 83.37 -119.58, 163.56 301.23, 100.14 146.26, -161.86 in-in in 8.355 Saltbr-in 3.032 HRD-in -75.87, -47.34 76.1, -11.46 in-out-none SNCion out-none ActLoopNT-out 9.669 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 107.51 APE9-dihe-in -145.96, 148.03 APE8-dihe-in -73.29, 89.61 APE8-rot-na 29.38 APE67-dihe-in -67.75, -13.33 -62.67, -32.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.547 APE9-dist-in 6.64 S901E None None XRAY 2.3 0.19 0.226 A 390 373 8 0 0 5 [[613, 873]] 1.0 7kjc TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 7KJCB P29317 590 965 976.0 ACP:61002 ATPlike Inactive DFGin 5.963 15.204 BLBminus -132.91, -166.6 60.51, 83.21 -117.48, 163.92 299.39, 100.57 145.47, 999.0 in-in in 8.467 Saltbr-in 3.13 HRD-in -75.7, -46.49 74.32, -9.38 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 86.32 APE8-rot-na 29.03 APE67-dihe-in -66.96, -12.86 -66.13, -32.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 S901E None None XRAY 2.3 0.19 0.226 B 390 347 23 0 0 20 [[613, 873]] 1.0 7kjc TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 7KJAA P29317 590 976 976.0 ACP:61002 ATPlike Inactive DFGin 5.763 14.769 BLBminus -129.59, -174.19 75.99, 88.0 -122.87, 170.51 304.47, 101.43 99.06, 999.0 in-in in 8.424 Saltbr-in 3.055 HRD-in -76.77, -48.29 79.69, -17.22 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.1 APE8-rot-na 32.23 APE67-dihe-in -70.25, -11.59 -65.39, -29.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.19 0.217 A 390 361 20 0 0 20 [[613, 873]] 1.0 7kja TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR FGFR1 FGFR1_HUMAN 3GQIA P11362 464 770 822.0 ACP:775 ATPlike Active DFGin 6.466 13.946 BLAminus -126.61, -175.83 60.19, 72.36 -91.08, 18.42 288.73, 91.63 -64.67, -15.4 in-in in 7.751 Saltbr-in 2.69 HRD-in -77.5, -49.87 72.48, -2.68 in-in-in SNCiii in-in ActLoopNT-in 2.961 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.96, 135.34 APE9-dihe-in -149.19, 136.62 APE8-dihe-in -75.51, 66.48 APE8-rot-na 33.4 APE67-dihe-in -65.08, -11.82 -44.91, -41.18 APE12-dist-na 14.083 APE11-dist-na 11.258 APE10-dist-na 10.128 APE9-dist-in 7.137 C488A,Y583F,C584S,Y585F PTR653,PTR654,PTR766 PTR653,PTR654,PTR766 XRAY 2.5 0.249 0.289 A 326 307 0 0 0 0 [[478, 756]] 1.0 3gqi TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR2 FGFR2_HUMAN 2PWLA P21802 467 764 821.0 ACP:300 ATPlike Inactive DFGin 6.451 14.178 BLAminus -131.61, -167.38 56.51, 73.64 -92.98, 26.06 293.6, 74.93 -63.45, -20.7 in-in in 7.586 Saltbr-in 2.856 HRD-in -77.4, -49.09 71.28, -7.85 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.03, 20.75 APE9-dihe-in -94.74, 135.38 APE8-dihe-in -58.69, 123.68 APE8-rot-na 326.81 APE67-dihe-in -69.99, -5.92 -52.74, -45.54 APE12-dist-na 10.002 APE11-dist-na 10.678 APE10-dist-na 7.432 APE9-dist-in 4.749 C491A,N549H None None XRAY 2.4 0.21 0.238 A 324 284 14 0 0 0 [[481, 759]] 1.0 2pwl TYR_FGFR2_HUMAN TYR 3.1e-104 353.8 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PWLB P21802 468 765 821.0 ACP:300 ATPlike Inactive DFGin 6.439 14.28 BLAminus -131.94, -168.62 54.17, 75.02 -93.02, 25.01 292.99, 76.23 -61.28, -25.59 in-in in 7.692 Saltbr-in 3.07 HRD-in -69.87, -47.96 69.48, -8.93 in-in-out SNCiio in-out ActLoopNT-in 2.916 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.23, 16.85 APE9-dihe-in -95.43, 136.0 APE8-dihe-in -55.13, 121.27 APE8-rot-na 324.13 APE67-dihe-in -66.61, -7.86 -55.94, -44.16 APE12-dist-na 10.089 APE11-dist-na 10.854 APE10-dist-na 7.485 APE9-dist-in 4.912 C491A,N549H None None XRAY 2.4 0.21 0.238 B 324 286 12 0 0 0 [[481, 759]] 1.0 2pwl TYR_FGFR2_HUMAN TYR 3.1e-104 353.8 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J96B P21802 462 766 821.0 ACP:803 ATPlike Inactive DFGin 6.422 14.069 BLAminus -135.07, -171.17 49.96, 77.75 -93.13, 20.28 283.65, 85.2 -66.67, -18.8 in-out in 7.205 Saltbr-out 3.691 HRD-in -86.85, -47.88 76.0, -13.66 out-in-out SNCoio in-out ActLoopNT-in 2.811 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.69, 28.85 APE9-dihe-in -99.38, 128.67 APE8-dihe-in -54.56, 125.51 APE8-rot-na 329.88 APE67-dihe-in -70.35, -5.29 -58.48, -39.96 APE12-dist-na 14.724 APE11-dist-na 10.154 APE10-dist-na 7.507 APE9-dist-in 4.93 C491A,K659M None None XRAY 2.297 0.178 0.219 B 324 305 0 0 0 0 [[481, 759]] 1.0 4j96 TYR_FGFR2_HUMAN TYR 2.7e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J98B P21802 461 764 821.0 ACP:804 ATPlike Inactive DFGin 6.55 14.042 BLAminus -130.09, -172.54 52.51, 78.98 -94.32, 21.96 285.07, 86.18 -63.61, -22.45 in-in in 7.113 Saltbr-in 3.017 HRD-in -86.21, -48.16 74.7, -12.01 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.22, 26.63 APE9-dihe-in -99.48, 124.84 APE8-dihe-in -50.97, 125.51 APE8-rot-na 328.99 APE67-dihe-in -68.16, -7.57 -60.28, -41.11 APE12-dist-na 15.096 APE11-dist-na 10.418 APE10-dist-na 7.58 APE9-dist-in 4.827 C491A,K659Q None None XRAY 2.307 0.19 0.234 B 324 304 0 0 0 0 [[481, 759]] 1.0 4j98 TYR_FGFR2_HUMAN TYR 2.1e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVFA P21802 467 765 821.0 ACP:60300 ATPlike Active DFGin 6.048 13.821 BLAminus -138.88, -175.17 54.67, 80.46 -90.11, 24.33 291.08, 76.38 -54.38, -36.38 in-in in 7.913 Saltbr-in 2.769 HRD-in -85.37, -48.4 70.03, 0.26 in-in-in SNCiii in-in ActLoopNT-in 2.879 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.94, 115.27 APE9-dihe-in -125.87, 160.91 APE8-dihe-in -74.41, 68.1 APE8-rot-na 35.92 APE67-dihe-in -70.82, -9.54 -47.44, -41.99 APE12-dist-na 15.14 APE11-dist-na 11.649 APE10-dist-na 11.604 APE9-dist-in 7.168 C491A PTR586,PTR656,PTR657 PTR586,PTR656,PTR657 XRAY 1.8 0.251 0.265 A 334 288 11 0 0 0 [[481, 759]] 1.0 2pvf TYR_FGFR2_HUMAN TYR 2.2e-104 354.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 3CLYA P21802 468 772 821.0 ACP:61803 ATPlike Active DFGin 6.229 14.183 BLAminus -138.78, -172.76 51.4, 79.79 -91.29, 32.46 290.47, 75.81 -61.86, -29.26 in-in in 7.661 Saltbr-in 2.621 HRD-in -89.86, -45.92 68.93, -0.84 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.79, 139.96 APE9-dihe-in -131.36, 152.18 APE8-dihe-in -76.17, 66.16 APE8-rot-na 37.1 APE67-dihe-in -66.78, -6.73 -47.95, -40.48 APE12-dist-na 13.253 APE11-dist-na 10.402 APE10-dist-na 11.097 APE9-dist-in 6.913 C491A PTR656,PTR657 PTR656,PTR657 XRAY 2.0 0.216 0.247 A 334 291 14 0 0 0 [[481, 759]] 1.0 3cly TYR_FGFR2_HUMAN TYR 2.2e-104 354.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J99A P21802 466 764 821.0 ACP:802 ATPlike Inactive DFGin 6.715 14.14 BLAminus -130.96, -174.69 58.83, 77.45 -92.73, 19.29 291.78, 87.39 -60.03, -34.11 in-in in 7.61 Saltbr-in 2.845 HRD-in -78.19, -48.52 73.01, -4.76 in-in-out SNCiio in-out ActLoopNT-in 2.861 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.36, 29.03 APE9-dihe-in -109.75, 138.54 APE8-dihe-in -57.3, 116.33 APE8-rot-na 330.48 APE67-dihe-in -70.7, -10.42 -57.47, -40.52 APE12-dist-na 15.04 APE11-dist-na 11.232 APE10-dist-na 7.972 APE9-dist-in 5.13 C491A,K659T None None XRAY 1.847 0.206 0.24 A 324 280 19 0 0 4 [[481, 759]] 1.0 4j99 TYR_FGFR2_HUMAN TYR 2e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J99B P21802 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.666 14.188 BLAminus -133.21, -176.0 58.56, 76.97 -94.04, 15.78 292.83, 99.53 -58.91, -32.83 in-in in 7.584 Saltbr-in 2.616 HRD-in -76.65, -48.86 73.31, -6.92 in-in-out SNCiio in-out ActLoopNT-in 2.9 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -118.89, 30.62 APE9-dihe-in -108.84, 137.25 APE8-dihe-in -57.12, 118.19 APE8-rot-na 330.19 APE67-dihe-in -70.1, -10.12 -57.01, -39.76 APE12-dist-na 14.148 APE11-dist-na 11.074 APE10-dist-na 8.007 APE9-dist-in 5.18 C491A,K659T None None XRAY 1.847 0.206 0.24 B 324 291 7 0 0 0 [[481, 759]] 1.0 4j99 TYR_FGFR2_HUMAN TYR 2e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J99C P21802 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.835 14.168 BLAminus -131.87, -175.54 59.17, 75.71 -91.42, 19.92 291.67, 85.71 -59.92, -32.59 in-in in 7.628 Saltbr-in 2.913 HRD-in -76.88, -47.72 74.23, -7.36 in-in-out SNCiio in-out ActLoopNT-in 2.894 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.66, 30.6 APE9-dihe-in -110.19, 138.06 APE8-dihe-in -55.44, 118.46 APE8-rot-na 330.51 APE67-dihe-in -70.73, -10.29 -57.12, -38.65 APE12-dist-na 14.121 APE11-dist-na 10.954 APE10-dist-na 8.05 APE9-dist-in 5.362 C491A,K659T None None XRAY 1.847 0.206 0.24 C 324 291 7 0 0 0 [[481, 759]] 1.0 4j99 TYR_FGFR2_HUMAN TYR 2e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J99D P21802 465 764 821.0 ACP:802 ATPlike Inactive DFGin 6.593 14.159 BLAminus -133.66, -174.57 58.72, 78.56 -92.61, 20.44 290.96, 82.99 -59.4, -33.38 in-in in 7.631 Saltbr-in 2.639 HRD-in -78.38, -50.11 73.68, -6.22 in-in-out SNCiio in-out ActLoopNT-in 2.893 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.76, 31.03 APE9-dihe-in -108.34, 137.61 APE8-dihe-in -55.35, 118.06 APE8-rot-na 330.85 APE67-dihe-in -71.9, -11.56 -55.67, -38.95 APE12-dist-na 999.0 APE11-dist-na 11.135 APE10-dist-na 7.859 APE9-dist-in 4.992 C491A,K659T None None XRAY 1.847 0.206 0.24 D 324 281 19 0 0 3 [[481, 759]] 1.0 4j99 TYR_FGFR2_HUMAN TYR 2e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVYA P21802 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.75 14.274 BLAminus -142.14, -176.01 63.9, 72.69 -96.2, 30.01 293.76, 86.07 -65.9, -30.73 in-in in 7.547 Saltbr-in 2.852 HRD-in -84.99, -48.7 74.29, -16.98 in-in-out SNCiio in-out ActLoopNT-in 2.809 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.15, 32.71 APE9-dihe-in -103.67, 126.67 APE8-dihe-in -51.63, 122.63 APE8-rot-na 323.69 APE67-dihe-in -64.04, -12.74 -56.98, -40.88 APE12-dist-na 14.814 APE11-dist-na 10.095 APE10-dist-na 7.537 APE9-dist-in 4.955 C491A,K659N None None XRAY 2.2 0.236 0.276 A 324 288 10 0 0 0 [[481, 759]] 1.0 2pvy TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVYB P21802 462 764 821.0 ACP:8002 ATPlike Inactive DFGin 6.635 14.065 BLAminus -144.27, -177.95 57.14, 77.78 -93.97, 24.89 293.34, 84.21 -55.49, -34.1 in-in in 7.316 Saltbr-in 2.847 HRD-in -81.21, -48.71 71.97, -12.52 in-in-out SNCiio in-out ActLoopNT-in 2.852 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.68, 30.22 APE9-dihe-in -107.46, 135.49 APE8-dihe-in -57.98, 120.91 APE8-rot-na 329.38 APE67-dihe-in -64.69, -5.42 -51.47, -46.8 APE12-dist-na 999.0 APE11-dist-na 10.694 APE10-dist-na 7.435 APE9-dist-in 5.066 C491A,K659N None None XRAY 2.2 0.236 0.276 B 324 286 17 0 0 6 [[481, 759]] 1.0 2pvy TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVYC P21802 462 764 821.0 ACP:802 ATPlike Inactive DFGin 6.693 14.018 BLAminus -131.41, -174.32 49.42, 82.58 -94.81, 27.78 293.52, 79.4 -60.72, -24.91 in-in in 7.229 Saltbr-in 3.577 HRD-in -81.5, -47.6 72.07, -14.53 in-in-out SNCiio in-out ActLoopNT-in 2.794 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.89, 24.55 APE9-dihe-in -101.87, 134.03 APE8-dihe-in -55.3, 120.87 APE8-rot-na 330.19 APE67-dihe-in -64.04, -6.89 -51.83, -46.76 APE12-dist-na 14.316 APE11-dist-na 10.323 APE10-dist-na 7.438 APE9-dist-in 5.069 C491A,K659N None None XRAY 2.2 0.236 0.276 C 324 285 18 0 0 5 [[481, 759]] 1.0 2pvy TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVYD P21802 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.944 14.261 BLAminus -139.76, -174.3 61.15, 74.17 -97.41, 31.68 293.81, 79.18 -66.75, -30.92 in-in in 7.298 Saltbr-in 3.036 HRD-in -85.65, -49.02 75.46, -18.01 in-in-out SNCiio in-out ActLoopNT-in 2.811 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.37, 33.11 APE9-dihe-in -102.8, 126.29 APE8-dihe-in -51.84, 123.89 APE8-rot-na 324.49 APE67-dihe-in -63.66, -13.12 -61.69, -37.66 APE12-dist-na 14.828 APE11-dist-na 10.092 APE10-dist-na 7.57 APE9-dist-in 4.968 C491A,K659N None None XRAY 2.2 0.236 0.276 D 324 283 15 0 0 0 [[481, 759]] 1.0 2pvy TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J95A P21802 467 764 821.0 ACP:801 ATPlike Inactive DFGin 6.691 14.058 BLAminus -131.56, -174.19 63.25, 76.63 -98.25, 22.24 292.31, 85.68 -64.6, -23.3 in-in in 7.752 Saltbr-in 2.811 HRD-in -79.93, -52.54 74.87, -4.09 in-in-out SNCiio in-out ActLoopNT-in 2.992 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.79, 21.67 APE9-dihe-in -99.53, 131.21 APE8-dihe-in -54.93, 120.24 APE8-rot-na 331.68 APE67-dihe-in -73.86, -8.05 -61.39, -39.09 APE12-dist-na 14.773 APE11-dist-na 10.953 APE10-dist-na 7.48 APE9-dist-in 4.867 C491A,K659N None None XRAY 2.377 0.214 0.255 A 324 279 19 0 0 4 [[481, 759]] 1.0 4j95 TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J95B P21802 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.677 14.378 BLAminus -131.79, -176.38 62.78, 77.42 -96.59, 21.6 290.19, 86.46 -65.99, -23.31 in-in in 7.797 Saltbr-in 2.903 HRD-in -80.06, -52.15 74.05, -5.91 in-in-out SNCiio in-out ActLoopNT-in 2.897 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.95, 20.73 APE9-dihe-in -101.19, 131.88 APE8-dihe-in -53.9, 121.25 APE8-rot-na 331.03 APE67-dihe-in -73.96, -6.54 -59.67, -39.95 APE12-dist-na 14.977 APE11-dist-na 11.021 APE10-dist-na 7.709 APE9-dist-in 4.856 C491A,K659N None None XRAY 2.377 0.214 0.255 B 324 282 15 0 0 0 [[481, 759]] 1.0 4j95 TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J95C P21802 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.762 14.317 BLAminus -132.19, -176.54 63.57, 76.14 -98.34, 23.39 290.03, 85.39 -65.87, -22.89 in-in in 7.736 Saltbr-in 2.825 HRD-in -79.64, -52.73 75.27, -7.0 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.5, 23.85 APE9-dihe-in -97.28, 128.27 APE8-dihe-in -54.92, 121.79 APE8-rot-na 330.61 APE67-dihe-in -73.19, -7.42 -60.17, -39.19 APE12-dist-na 14.732 APE11-dist-na 10.365 APE10-dist-na 7.413 APE9-dist-in 4.906 C491A,K659N None None XRAY 2.377 0.214 0.255 C 324 281 16 0 0 0 [[481, 759]] 1.0 4j95 TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J95D P21802 467 764 821.0 ACP:801 ATPlike Inactive DFGin 6.601 14.074 BLAminus -131.84, -175.28 62.91, 77.06 -96.79, 22.82 289.52, 85.1 -64.56, -22.95 in-in in 7.641 Saltbr-in 2.747 HRD-in -80.37, -53.3 74.73, -6.2 in-in-out SNCiio in-out ActLoopNT-in 3.033 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.03, 23.13 APE9-dihe-in -98.93, 130.46 APE8-dihe-in -52.66, 122.62 APE8-rot-na 330.72 APE67-dihe-in -75.07, -8.74 -59.5, -40.3 APE12-dist-na 999.0 APE11-dist-na 10.804 APE10-dist-na 7.616 APE9-dist-in 4.803 C491A,K659N None None XRAY 2.377 0.214 0.255 D 324 271 27 0 0 11 [[481, 759]] 1.0 4j95 TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZ5A P21802 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.27 14.129 BLAminus -134.55, -165.25 46.14, 76.71 -87.82, 24.61 288.3, 73.06 -57.77, -17.99 in-in in 7.376 Saltbr-in 2.72 HRD-in -71.49, -53.18 74.61, -7.33 in-in-out SNCiio in-out ActLoopNT-in 2.954 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.92, 23.05 APE9-dihe-in -100.29, 130.1 APE8-dihe-in -50.24, 116.35 APE8-rot-na 324.43 APE67-dihe-in -70.43, -5.4 -48.06, -44.87 APE12-dist-na 10.162 APE11-dist-na 10.892 APE10-dist-na 7.555 APE9-dist-in 4.83 C491A,N549T None None XRAY 2.4 0.214 0.254 A 324 280 19 0 0 0 [[481, 759]] 1.0 2pz5 TYR_FGFR2_HUMAN TYR 4.5e-104 353.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZ5B P21802 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.42 14.223 BLAminus -139.02, -170.4 49.42, 74.35 -88.07, 29.83 289.06, 77.09 -65.84, -12.67 in-in in 7.304 Saltbr-in 2.773 HRD-in -68.79, -48.45 71.17, -10.83 in-in-out SNCiio in-out ActLoopNT-in 2.924 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.66, 23.86 APE9-dihe-in -102.44, 130.7 APE8-dihe-in -54.21, 119.21 APE8-rot-na 323.97 APE67-dihe-in -67.2, -7.87 -53.61, -43.12 APE12-dist-na 10.046 APE11-dist-na 10.812 APE10-dist-na 7.393 APE9-dist-in 4.981 C491A,N549T None None XRAY 2.4 0.214 0.254 B 324 280 19 0 0 0 [[481, 759]] 1.0 2pz5 TYR_FGFR2_HUMAN TYR 4.5e-104 353.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J97A P21802 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.55 14.123 BLAminus -139.14, -173.61 59.78, 71.54 -95.85, 23.3 290.64, 88.77 -67.56, -16.73 in-in in 7.316 Saltbr-in 3.004 HRD-in -83.97, -47.07 72.51, -7.44 in-in-out SNCiio in-out ActLoopNT-in 2.877 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.39, 21.13 APE9-dihe-in -97.79, 130.15 APE8-dihe-in -58.11, 126.83 APE8-rot-na 332.95 APE67-dihe-in -66.85, -7.34 -61.56, -42.87 APE12-dist-na 15.336 APE11-dist-na 10.692 APE10-dist-na 7.744 APE9-dist-in 4.882 C491A,K659E None None XRAY 2.548 0.202 0.257 A 324 282 15 0 0 0 [[481, 759]] 1.0 4j97 TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J97B P21802 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.619 14.161 BLAminus -137.2, -170.97 56.98, 77.11 -102.2, 28.96 291.71, 89.32 -70.08, -17.2 in-in in 7.432 Saltbr-in 2.683 HRD-in -92.02, -43.47 71.93, -10.83 in-in-out SNCiio in-out ActLoopNT-in 2.882 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.22, 28.28 APE9-dihe-in -102.89, 130.04 APE8-dihe-in -52.94, 125.61 APE8-rot-na 331.88 APE67-dihe-in -68.38, -8.99 -59.09, -43.64 APE12-dist-na 15.333 APE11-dist-na 10.637 APE10-dist-na 7.778 APE9-dist-in 4.888 C491A,K659E None None XRAY 2.548 0.202 0.257 B 324 283 14 0 0 0 [[481, 759]] 1.0 4j97 TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J97C P21802 467 764 821.0 ACP:801 ATPlike Inactive DFGin 6.645 13.946 BLAminus -135.48, -176.12 59.98, 78.76 -103.0, 29.61 294.18, 85.28 -73.23, -9.75 in-in in 7.37 Saltbr-in 2.772 HRD-in -84.13, -44.14 69.93, -6.04 in-in-out SNCiio in-out ActLoopNT-in 2.837 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.47, 19.13 APE9-dihe-in -91.95, 123.86 APE8-dihe-in -53.96, 120.55 APE8-rot-na 330.23 APE67-dihe-in -67.12, -15.11 -56.46, -44.57 APE12-dist-na 15.284 APE11-dist-na 10.828 APE10-dist-na 7.639 APE9-dist-in 4.85 C491A,K659E None None XRAY 2.548 0.202 0.257 C 324 283 15 0 0 0 [[481, 759]] 1.0 4j97 TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J97D P21802 466 764 821.0 ACP:801 ATPlike Inactive DFGin 6.6 13.952 BLAminus -140.55, -174.15 59.58, 71.6 -94.76, 28.97 293.72, 82.5 -71.76, -12.96 in-in in 7.326 Saltbr-in 3.288 HRD-in -86.64, -45.82 71.0, -4.65 in-in-out SNCiio in-out ActLoopNT-in 2.976 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.43, 15.17 APE9-dihe-in -92.91, 126.7 APE8-dihe-in -55.77, 123.75 APE8-rot-na 332.18 APE67-dihe-in -67.8, -5.5 -58.98, -44.55 APE12-dist-na 15.175 APE11-dist-na 10.81 APE10-dist-na 7.653 APE9-dist-in 4.774 C491A,K659E None None XRAY 2.548 0.202 0.257 D 324 285 14 0 0 0 [[481, 759]] 1.0 4j97 TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZPA P21802 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.348 14.188 BLAminus -137.17, -165.33 46.36, 75.76 -87.8, 26.94 288.76, 75.56 -66.87, -3.87 in-in in 7.412 Saltbr-in 2.646 HRD-in -73.32, -51.09 75.46, -8.12 in-in-out SNCiio in-out ActLoopNT-in 2.85 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.47, 19.17 APE9-dihe-in -100.03, 131.76 APE8-dihe-in -52.44, 119.43 APE8-rot-na 323.26 APE67-dihe-in -75.98, -2.12 -50.98, -36.8 APE12-dist-na 10.034 APE11-dist-na 10.845 APE10-dist-na 7.456 APE9-dist-in 4.835 C491A,K526E None None XRAY 2.4 0.214 0.251 A 324 280 19 0 0 0 [[481, 759]] 1.0 2pzp TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZPB P21802 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.413 14.352 BLAminus -140.32, -168.12 49.24, 73.06 -87.89, 30.48 288.51, 77.76 -65.07, -14.98 in-in in 7.479 Saltbr-in 2.588 HRD-in -76.07, -43.76 66.74, -12.17 in-in-out SNCiio in-out ActLoopNT-in 2.931 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.0, 26.29 APE9-dihe-in -103.21, 127.34 APE8-dihe-in -50.89, 117.65 APE8-rot-na 324.07 APE67-dihe-in -70.61, -2.41 -52.07, -42.82 APE12-dist-na 10.141 APE11-dist-na 10.802 APE10-dist-na 7.451 APE9-dist-in 4.964 C491A,K526E None None XRAY 2.4 0.214 0.251 B 324 282 17 0 0 0 [[481, 759]] 1.0 2pzp TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZRA P21802 468 765 821.0 ACP:803 ATPlike Inactive DFGin 6.528 14.087 BLAminus -124.48, -173.68 60.99, 80.27 -100.69, 20.88 290.45, 81.11 -57.12, -25.75 in-in in 7.418 Saltbr-in 2.648 HRD-in -69.22, -43.88 65.36, -10.35 in-in-out SNCiio in-out ActLoopNT-in 2.833 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -123.95, 17.65 APE9-dihe-in -96.03, 130.55 APE8-dihe-in -55.73, 111.71 APE8-rot-na 326.73 APE67-dihe-in -57.11, -22.38 -39.78, -52.21 APE12-dist-na 9.973 APE11-dist-na 10.692 APE10-dist-na 7.386 APE9-dist-in 4.734 C491A,K641R None None XRAY 3.0 0.201 0.268 A 324 280 18 0 0 0 [[481, 759]] 1.0 2pzr TYR_FGFR2_HUMAN TYR 8.4e-104 352.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZRB P21802 467 766 821.0 ACP:803 ATPlike Inactive DFGin 6.446 14.135 BLAminus -124.12, -169.42 57.57, 72.92 -93.39, 13.68 295.44, 82.57 -53.73, -21.74 in-in in 7.634 Saltbr-in 2.706 HRD-in -69.55, -51.19 76.09, -22.69 in-in-out SNCiio in-out ActLoopNT-in 2.945 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.28, 13.02 APE9-dihe-in -94.85, 132.36 APE8-dihe-in -55.27, 118.14 APE8-rot-na 326.76 APE67-dihe-in -72.22, 2.52 -57.29, -38.32 APE12-dist-na 9.949 APE11-dist-na 10.979 APE10-dist-na 7.519 APE9-dist-in 5.016 C491A,K641R None None XRAY 3.0 0.201 0.268 B 324 282 18 0 0 0 [[481, 759]] 1.0 2pzr TYR_FGFR2_HUMAN TYR 8.4e-104 352.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UHNA P21802 469 764 821.0 ACP:802 ATPlike Inactive DFGin 6.517 14.094 BLAminus -136.8, -167.33 56.16, 78.56 -101.45, 21.6 294.96, 102.9 -64.06, -30.14 in-in in 7.824 Saltbr-in 2.523 HRD-in -81.24, -42.19 65.24, 0.64 in-in-out SNCiio in-out ActLoopNT-in 2.963 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -130.72, 22.85 APE9-dihe-in -103.03, 139.99 APE8-dihe-in -59.98, 123.73 APE8-rot-na 335.04 APE67-dihe-in -66.52, -14.98 -63.65, -42.1 APE12-dist-na 14.855 APE11-dist-na 10.903 APE10-dist-na 7.587 APE9-dist-in 4.884 N549H,E565A None None XRAY 2.909 0.26 0.311 A 324 282 14 0 0 0 [[481, 759]] 1.0 5uhn TYR_FGFR2_HUMAN TYR 3.3e-103 350.5 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UHNB P21802 469 764 821.0 ACP:802 ATPlike Inactive DFGin 6.513 14.023 BLAminus -136.33, -166.28 57.28, 77.94 -101.83, 20.57 295.09, 103.12 -64.81, -29.84 in-in in 7.663 Saltbr-in 2.464 HRD-in -80.51, -42.21 65.56, -0.07 in-in-out SNCiio in-out ActLoopNT-in 3.183 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -129.68, 22.67 APE9-dihe-in -103.05, 139.67 APE8-dihe-in -60.5, 125.01 APE8-rot-na 334.93 APE67-dihe-in -66.52, -14.36 -63.18, -41.76 APE12-dist-na 999.0 APE11-dist-na 10.814 APE10-dist-na 7.591 APE9-dist-in 4.817 N549H,E565A None None XRAY 2.909 0.26 0.311 B 324 269 27 0 0 11 [[481, 759]] 1.0 5uhn TYR_FGFR2_HUMAN TYR 3.3e-103 350.5 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UGXA P21802 468 764 821.0 ACP:803 ATPlike Inactive DFGin 6.657 14.049 BLAminus -131.13, -166.11 46.79, 87.05 -100.0, 21.89 288.47, 85.57 -64.83, -24.6 in-in in 7.609 Saltbr-in 2.992 HRD-in -78.16, -51.21 73.9, -1.28 in-in-out SNCiio in-out ActLoopNT-in 2.867 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.33, 9.75 APE9-dihe-in -97.42, 138.88 APE8-dihe-in -59.74, 121.4 APE8-rot-na 334.26 APE67-dihe-in -70.7, -5.46 -65.5, -39.78 APE12-dist-na 15.029 APE11-dist-na 11.177 APE10-dist-na 7.458 APE9-dist-in 4.804 C491A,E565A None None XRAY 2.349 0.22 0.275 A 324 297 0 0 0 0 [[481, 759]] 1.0 5ugx TYR_FGFR2_HUMAN TYR 4.5e-103 350.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UGXB P21802 468 764 821.0 ACP:803 ATPlike Inactive DFGin 6.711 13.923 BLAminus -132.31, -170.71 52.3, 81.71 -96.0, 22.25 292.25, 87.7 -65.69, -25.27 in-in in 7.393 Saltbr-in 3.154 HRD-in -75.61, -53.17 73.28, -1.77 in-in-out SNCiio in-out ActLoopNT-in 2.92 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.49, 16.52 APE9-dihe-in -100.17, 138.41 APE8-dihe-in -61.9, 122.99 APE8-rot-na 336.36 APE67-dihe-in -71.64, -5.56 -62.65, -38.67 APE12-dist-na 10.081 APE11-dist-na 10.766 APE10-dist-na 7.282 APE9-dist-in 4.828 C491A,E565A None None XRAY 2.349 0.22 0.275 B 324 282 15 0 0 10 [[481, 759]] 1.0 5ugx TYR_FGFR2_HUMAN TYR 4.5e-103 350.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UI0B P21802 462 765 821.0 ACP:802 ATPlike Inactive DFGin 6.542 14.213 BLAminus -136.98, -171.82 50.02, 76.91 -91.39, 21.0 284.06, 84.3 -70.34, -15.26 in-in in 7.243 Saltbr-in 2.959 HRD-in -80.63, -49.98 74.74, -10.37 in-in-out SNCiio in-out ActLoopNT-in 2.937 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.5, 32.27 APE9-dihe-in -102.72, 128.27 APE8-dihe-in -51.42, 123.86 APE8-rot-na 328.96 APE67-dihe-in -69.39, -7.95 -60.08, -38.03 APE12-dist-na 14.784 APE11-dist-na 10.166 APE10-dist-na 7.606 APE9-dist-in 4.855 C491A,E565A None None XRAY 2.05 0.183 0.207 B 324 304 0 0 0 0 [[481, 759]] 1.0 5ui0 TYR_FGFR2_HUMAN TYR 2.9e-103 350.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2Q0BA P21802 468 765 821.0 ACP:803 ATPlike Inactive DFGin 6.538 14.238 BLAminus -137.67, -164.26 54.31, 72.63 -95.24, 25.26 285.39, 75.18 -61.23, -29.58 in-in in 7.243 Saltbr-in 2.723 HRD-in -79.58, -49.69 74.6, -12.22 in-in-out SNCiio in-out ActLoopNT-in 2.975 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -123.18, 17.09 APE9-dihe-in -97.34, 129.87 APE8-dihe-in -55.33, 120.72 APE8-rot-na 329.23 APE67-dihe-in -73.97, -8.32 -57.44, -31.43 APE12-dist-na 9.977 APE11-dist-na 10.659 APE10-dist-na 7.369 APE9-dist-in 4.751 C491A,E565A None None XRAY 2.9 0.202 0.252 A 324 280 18 0 0 0 [[481, 759]] 1.0 2q0b TYR_FGFR2_HUMAN TYR 2.1e-103 351.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2Q0BB P21802 468 766 821.0 ACP:803 ATPlike Inactive DFGin 6.564 14.08 BLAminus -133.38, -173.77 65.46, 65.65 -91.7, 18.1 296.71, 72.83 -55.14, -29.53 in-in in 7.517 Saltbr-in 2.736 HRD-in -79.58, -50.53 70.04, -4.81 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.91, 21.68 APE9-dihe-in -99.61, 129.39 APE8-dihe-in -57.39, 112.59 APE8-rot-na 331.0 APE67-dihe-in -63.49, -9.98 -54.36, -36.94 APE12-dist-na 10.247 APE11-dist-na 10.839 APE10-dist-na 7.492 APE9-dist-in 4.906 C491A,E565A None None XRAY 2.9 0.202 0.252 B 324 282 17 0 0 0 [[481, 759]] 1.0 2q0b TYR_FGFR2_HUMAN TYR 2.1e-103 351.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PY3A P21802 468 766 821.0 ACP:805 ATPlike Inactive DFGin 6.395 14.125 BLAminus -132.09, -167.28 46.92, 77.9 -89.52, 28.18 287.97, 74.42 -64.92, -12.84 in-in in 7.278 Saltbr-in 2.643 HRD-in -69.15, -50.28 73.37, -7.92 in-in-out SNCiio in-out ActLoopNT-in 2.937 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.57, 22.43 APE9-dihe-in -99.04, 131.25 APE8-dihe-in -52.37, 122.48 APE8-rot-na 325.05 APE67-dihe-in -72.14, -6.33 -51.92, -40.9 APE12-dist-na 9.95 APE11-dist-na 10.671 APE10-dist-na 7.386 APE9-dist-in 4.744 C491A,E565G None None XRAY 2.3 0.217 0.252 A 324 282 17 0 0 0 [[481, 759]] 1.0 2py3 TYR_FGFR2_HUMAN TYR 2.7e-103 350.7 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PY3B P21802 468 766 821.0 ACP:805 ATPlike Inactive DFGin 6.515 14.301 BLAminus -135.62, -170.09 51.9, 73.7 -89.2, 28.31 287.78, 75.56 -66.05, -13.03 in-in in 7.425 Saltbr-in 2.704 HRD-in -75.46, -47.46 71.33, -10.27 in-in-out SNCiio in-out ActLoopNT-in 2.857 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.61, 23.33 APE9-dihe-in -100.25, 127.63 APE8-dihe-in -52.55, 116.2 APE8-rot-na 325.69 APE67-dihe-in -68.53, -13.02 -47.88, -42.42 APE12-dist-na 10.066 APE11-dist-na 10.788 APE10-dist-na 7.419 APE9-dist-in 4.931 C491A,E565G None None XRAY 2.3 0.217 0.252 B 324 284 15 0 0 0 [[481, 759]] 1.0 2py3 TYR_FGFR2_HUMAN TYR 2.7e-103 350.7 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5EG3A P21802 466 774 821.0 ACP:60801 ATPlike Active DFGin 6.034 13.825 BLAminus -138.71, -166.61 47.53, 87.44 -100.17, 28.73 285.85, 82.29 -77.8, -14.99 in-in in 8.045 Saltbr-in 2.941 HRD-in -83.82, -45.21 62.18, 9.75 in-in-in SNCiii in-in ActLoopNT-in 2.991 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.56, 121.06 APE9-dihe-in -128.9, 119.34 APE8-dihe-in -79.6, 67.11 APE8-rot-na 30.51 APE67-dihe-in -77.81, 0.08 -48.0, -39.27 APE12-dist-na 13.558 APE11-dist-na 10.078 APE10-dist-na 8.259 APE9-dist-in 7.021 Y466F,C491A,E565A,Y586L,Y588P,Y656F,Y657F,K659E PTR769 PTR769 XRAY 2.606 0.191 0.237 A 334 302 7 0 0 0 [[481, 759]] 1.0 5eg3 TYR_FGFR2_HUMAN TYR 2.3e-101 344.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 6V6QA P21802 466 765 821.0 ACP:901 ATPlike Inactive DFGin 6.894 13.908 BLAminus -137.26, -178.98 59.51, 71.9 -86.77, 13.5 292.04, 83.56 -59.04, -31.29 in-in in 7.246 Saltbr-in 3.289 HRD-in -72.64, -45.97 77.04, -16.81 in-in-out SNCiio in-out ActLoopNT-in 2.928 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.45, 33.95 APE9-dihe-in -111.95, 129.79 APE8-dihe-in -53.65, 121.81 APE8-rot-na 327.05 APE67-dihe-in -70.56, -11.31 -58.83, -38.12 APE12-dist-na 14.264 APE11-dist-na 10.49 APE10-dist-na 7.77 APE9-dist-in 5.206 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 A 411 286 14 0 0 0 [[481, 759]] 1.0 6v6q TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 6V6QB P21802 467 766 821.0 ACP:901 ATPlike Inactive DFGin 6.809 14.125 BLAminus -136.61, -177.61 60.52, 69.31 -88.63, 15.47 290.7, 96.84 -63.12, -28.34 in-in in 7.343 Saltbr-in 3.295 HRD-in -73.07, -46.4 74.87, -14.44 in-in-out SNCiio in-out ActLoopNT-in 2.92 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.84, 37.71 APE9-dihe-in -109.58, 130.31 APE8-dihe-in -50.87, 122.1 APE8-rot-na 324.14 APE67-dihe-in -69.97, -12.27 -61.49, -37.1 APE12-dist-na 14.135 APE11-dist-na 10.587 APE10-dist-na 8.065 APE9-dist-in 5.152 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 B 411 291 9 0 0 0 [[481, 759]] 1.0 6v6q TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 6V6QD P21802 467 765 821.0 ACP:901 ATPlike Inactive DFGin 6.936 13.989 BLAminus -136.56, -179.05 59.21, 72.83 -88.1, 16.16 292.51, 97.85 -58.15, -33.51 in-in in 7.38 Saltbr-in 3.334 HRD-in -71.81, -47.08 75.08, -13.84 in-in-out SNCiio in-out ActLoopNT-in 2.942 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.25, 35.34 APE9-dihe-in -111.85, 128.58 APE8-dihe-in -53.13, 121.4 APE8-rot-na 327.69 APE67-dihe-in -69.26, -12.5 -60.26, -36.04 APE12-dist-na 999.0 APE11-dist-na 10.14 APE10-dist-na 7.433 APE9-dist-in 5.112 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 D 411 276 23 0 0 9 [[481, 759]] 1.0 6v6q TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 6V6QC P21802 467 766 821.0 ACP:901 ATPlike Inactive DFGin 6.766 13.643 BLBminus -136.89, -177.89 59.28, 74.24 -85.91, -161.66 300.29, 95.93 81.23, -12.62 in-in in 7.463 Saltbr-in 3.314 HRD-in -72.01, -47.4 74.74, -13.46 in-in-out SNCiio in-out ActLoopNT-in 2.941 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.47, 28.67 APE9-dihe-in -111.04, 128.94 APE8-dihe-in -52.92, 121.96 APE8-rot-na 327.46 APE67-dihe-in -69.24, -12.82 -58.84, -37.31 APE12-dist-na 999.0 APE11-dist-na 10.498 APE10-dist-na 7.431 APE9-dist-in 5.088 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 C 411 279 21 0 0 11 [[481, 759]] 1.0 6v6q TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR3 FGFR3_HUMAN 4K33A P22607 459 755 806.0 ACP:801 ATPlike Active DFGin 6.252 13.787 BLAminus -133.88, -173.58 58.49, 82.81 -96.43, 27.55 291.81, 80.95 -59.32, -31.32 in-in in 8.211 Saltbr-in 2.895 HRD-in -87.09, -47.34 67.06, 1.63 in-in-in SNCiii in-in ActLoopNT-in 2.99 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.89, 133.11 APE9-dihe-in -125.43, 130.21 APE8-dihe-in -78.76, 72.58 APE8-rot-na 29.71 APE67-dihe-in -71.45, -4.47 -50.14, -48.75 APE12-dist-na 13.31 APE11-dist-na 9.602 APE10-dist-na 8.305 APE9-dist-in 6.873 C482A,C582S,K650E None None XRAY 2.341 0.181 0.228 A 325 293 4 0 0 0 [[472, 750]] 1.0 4k33 TYR_FGFR3_HUMAN TYR 2.3e-104 354.2 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 6PNXA P22607 456 757 806.0 ACP:801 ATPlike Inactive DFGin 5.183 13.257 BLAplus -117.43, 165.96 59.53, 36.21 -90.35, -22.61 56.49, 88.29 -100.71, 20.75 in-out in 7.758 Saltbr-out 3.892 HRD-in -72.74, -43.96 72.66, -12.59 out-out-out SNCooo out-out ActLoopNT-out 8.611 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 61.32, -168.18 APE9-dihe-in -95.45, 138.6 APE8-dihe-in -83.08, 62.92 APE8-rot-na 32.84 APE67-dihe-in -77.59, -4.01 -63.19, -31.79 APE12-dist-na 17.76 APE11-dist-na 14.387 APE10-dist-na 16.475 APE9-dist-in 7.98 C482A,C582S,R669E None None XRAY 2.199 0.195 0.23 A 324 291 11 0 0 0 [[472, 750]] 1.0 6pnx TYR_FGFR3_HUMAN TYR 2.5e-104 354.1 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 6PNXB P22607 455 756 806.0 ACP:801 ATPlike Inactive DFGin 5.102 12.88 BLAplus -116.22, 163.18 57.59, 45.48 -96.33, -11.84 56.51, 88.18 -107.89, 22.55 in-in in 7.372 Saltbr-in 2.381 HRD-in -94.02, -38.66 69.29, -17.12 in-out-out SNCioo out-out ActLoopNT-out 4.149 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 54.33, 74.29 APE9-dihe-in -157.39, 146.53 APE8-dihe-in -79.85, 92.16 APE8-rot-na 29.38 APE67-dihe-in -64.97, -14.94 -62.55, -40.44 APE12-dist-na 17.529 APE11-dist-na 16.958 APE10-dist-na 14.632 APE9-dist-in 7.491 C482A,C582S,R669E None None XRAY 2.199 0.195 0.23 B 324 294 8 0 0 0 [[472, 750]] 1.0 6pnx TYR_FGFR3_HUMAN TYR 2.5e-104 354.1 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR IGF1R IGF1R_HUMAN 1K3AA P08069 988 1286 1367.0 ACP:60300 ATPlike Inactive DFGin 6.326 14.213 ABAminus -128.41, -4.91 -126.86, 131.72 -125.9, 30.62 307.04, 99.18 -55.79, -30.44 in-out in 9.005 Saltbr-out 4.763 HRD-in -68.21, -48.33 72.95, -10.46 out-in-in SNCoii in-in ActLoopNT-in 2.922 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.81, 106.37 APE9-dihe-in -118.2, 152.14 APE8-dihe-in -73.75, 68.45 APE8-rot-na 35.41 APE67-dihe-in -73.37, -1.85 -44.97, -44.15 APE12-dist-na 15.179 APE11-dist-na 11.105 APE10-dist-na 10.844 APE9-dist-in 7.129 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.1 0.212 0.251 A 299 291 8 0 0 0 [[999, 1268]] 1.0 1k3a TYR_IGF1R_HUMAN TYR 3.1e-95 324.3 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR INSR INSR_HUMAN 4XLVA P06213 1001 1310 1382.0 ACP:61301 ATPlike Active DFGin 6.357 13.404 BLAminus -129.47, -169.61 59.33, 81.3 -99.86, 10.75 301.2, 100.62 -50.37, -35.15 in-in in 8.175 Saltbr-in 2.441 HRD-in -74.09, -41.95 72.32, -7.69 in-in-in SNCiii in-in ActLoopNT-in 3.029 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -31.8, 98.01 APE9-dihe-in -128.43, 131.43 APE8-dihe-in -62.62, 111.75 APE8-rot-na 18.22 APE67-dihe-in -71.49, -19.39 -64.21, -23.54 APE12-dist-na 14.741 APE11-dist-na 10.551 APE10-dist-na 11.027 APE9-dist-in 6.615 Y992F,C1008S PTR999,PTR1185,PTR1189,PTR1190 PTR999,PTR1185,PTR1189,PTR1190 XRAY 2.3 0.207 0.266 A 328 310 0 0 0 0 [[1023, 1292]] 1.0 4xlv TYR_INSR_HUMAN TYR 1.7e-96 328.5 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR INSR INSR_HUMAN 1I44A P06213 1013 1310 1382.0 ACP:60300 ATPlike Inactive DFGin 6.641 13.72 None -58.16, -57.88 -145.23, -170.38 -78.54, 6.88 58.45, 76.71 123.48, 176.59 in-out in 9.122 Saltbr-out 5.895 HRD-in -61.91, -52.97 77.04, -9.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -75.06 APE8-dihe-out -68.29, 48.19 APE8-rot-na 34.45 APE67-dihe-in -67.23, -7.11 -39.74, -51.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.683 C1008S,Y1011F,D1188A None None XRAY 2.4 0.21 0.268 A 306 282 16 0 0 16 [[1023, 1292]] 1.0 1i44 TYR_INSR_HUMAN TYR 3.4e-96 327.5 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR TNK2 ACK1_HUMAN 1U54A Q07912 115 390 1038.0 ACP:101 ATPlike Inactive DFGin 6.381 13.426 ABAminus -129.39, -12.11 -146.47, 102.96 -102.84, 23.33 304.65, 105.91 -57.05, -37.37 in-in in 7.864 Saltbr-in 2.624 HRD-in -77.15, -49.8 83.51, -10.59 in-in-none SNCiin in-none ActLoopNT-in 2.835 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.54 APE8-dihe-in -75.47, 123.76 APE8-rot-na 349.96 APE67-dihe-in -43.9, -19.78 -62.08, -52.54 APE12-dist-na 11.808 APE11-dist-na 8.141 APE10-dist-na 999.0 APE9-dist-in 6.063 None PTR284 PTR284 XRAY 2.8 0.226 0.322 A 291 263 13 0 0 1 [[126, 387]] 1.0 1u54 TYR_TNK2_HUMAN TYR 9e-86 293.3 1 259 259 269 270 271 273 275 158 177 181 249 251 250 252 312 300 295 294 293 292 291 290 289 206 Activated CDC42 kinase 1
TYR TNK2 ACK1_HUMAN 1U54B Q07912 117 388 1038.0 ACP:400 ATPlike Active DFGin 6.615 13.378 BLAminus -120.4, -155.16 27.84, 85.75 -104.36, 38.7 310.01, 93.15 -67.71, -28.73 in-in in 7.966 Saltbr-in 3.021 HRD-in -109.84, -42.56 64.6, 13.11 in-in-in SNCiii in-in ActLoopNT-in 3.014 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -150.8, 133.1 APE9-dihe-in -126.86, 129.0 APE8-dihe-in -43.1, 130.27 APE8-rot-na 329.12 APE67-dihe-in -70.13, -6.6 -62.78, -39.45 APE12-dist-na 12.662 APE11-dist-na 7.646 APE10-dist-na 11.0 APE9-dist-in 5.878 None None None XRAY 2.8 0.226 0.322 B 291 261 11 0 0 0 [[126, 387]] 1.0 1u54 TYR_TNK2_HUMAN TYR 9e-86 293.3 1 259 259 269 270 271 273 275 158 177 181 249 251 250 252 312 300 295 294 293 292 291 290 289 206 Activated CDC42 kinase 1

Ligand: ACP

Total number of chains: 100
Active chains: 11
Total number of genes: 24
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 68 68.0% 4F0FA
DFGin BLBplus 10 10.0% 4ANBA
DFGin ABAminus 7 7.0% 5X1SA
DFGin BLBminus 5 5.0% 7KJCA
DFGin None 3 3.0% 4C3PA
None None 3 3.0% 6I2PA
DFGin BLAplus 2 2.0% 6PNXB
DFGinter None 2 2.0% 4C3RA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL ROCO4 ROCO4_DICDI 4F0FA Q6XHB2 1019 1292 1726.0 ACP:61301 ATPlike Inactive DFGin 6.95 15.963 BLAminus -130.66, 172.28 62.24, 70.89 -92.37, 29.04 286.11, 76.52 -66.1, -24.87 in-in in 8.455 Saltbr-in 2.573 HRD-in -73.46, -44.25 65.79, 5.9 in-in-out SNCiio in-out ActLoopNT-in 2.599 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -114.23, 137.57 APE9-dihe-na -90.18, -37.76 APE8-dihe-in -70.88, 120.21 APE8-rot-na 222.83 APE67-dihe-in -78.4, -5.47 -115.68, -26.3 APE12-dist-in 10.18 APE11-dist-in 12.511 APE10-dist-out 9.222 APE9-dist-out 8.3 None None None XRAY 1.8 0.198 0.245 A 287 274 0 0 0 0 [[1026, 1291]] 1.0 4f0f Dictyostelium discoideum TKL_ROCO4_DICDI TKL 3.2e-59 206.6 2 266 265 1176 1177 1178 1180 1182 1055 1078 1082 1151 1153 1152 1154 1215 1201 1196 1195 1194 1193 1192 1191 1190 1106 Probable serine/threonine-protein kinase roco4
TKL ROCO4 ROCO4_DICDI 4F1OA Q6XHB2 1019 1292 1726.0 ACP:61301 ATPlike Inactive DFGin 7.11 15.543 BLAminus -139.35, 175.97 61.59, 71.39 -91.48, 35.72 286.47, 73.49 -70.25, -38.98 in-in in 8.086 Saltbr-in 2.782 HRD-in -70.19, -38.92 67.65, -6.5 in-in-out SNCiio in-out ActLoopNT-in 2.702 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -99.87, 151.06 APE9-dihe-na -83.99, -54.56 APE8-dihe-in -77.41, 78.95 APE8-rot-na 217.99 APE67-dihe-in -67.17, -15.56 -63.92, -29.08 APE12-dist-in 10.348 APE11-dist-in 12.806 APE10-dist-out 9.072 APE9-dist-out 8.14 None None None XRAY 2.3 0.252 0.296 A 287 274 0 0 0 0 [[1026, 1291]] 1.0 4f1o Dictyostelium discoideum TKL_ROCO4_DICDI TKL 1.1e-58 204.8 2 266 265 1176 1177 1178 1180 1182 1055 1078 1082 1151 1153 1152 1154 1215 1201 1196 1195 1194 1193 1192 1191 1190 1106 Probable serine/threonine-protein kinase roco4
TKL ROCO4 ROCO4_DICDI 4F1MA Q6XHB2 1019 1292 1726.0 ACP:61301,BTB:61302 ATPlike,Allosteric Inactive DFGin 6.734 15.31 BLAminus -135.93, 167.45 61.64, 76.62 -97.37, 30.41 286.17, 86.15 -92.2, 166.07 in-in in 8.148 Saltbr-in 2.843 HRD-in -65.4, -53.97 73.14, 3.41 in-in-out SNCiio in-out ActLoopNT-in 2.704 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -114.68, 138.58 APE9-dihe-na -71.39, -65.99 APE8-dihe-in -65.85, 83.01 APE8-rot-na 289.29 APE67-dihe-in -75.86, -13.39 -67.18, -17.16 APE12-dist-in 10.016 APE11-dist-in 11.777 APE10-dist-out 8.678 APE9-dist-out 7.791 G1179S None None XRAY 2.04 0.263 0.294 A 287 274 0 0 0 0 [[1026, 1291]] 1.0 4f1m Dictyostelium discoideum TKL_ROCO4_DICDI TKL 3.2e-58 203.3 2 266 265 1176 1177 1178 1180 1182 1055 1078 1082 1151 1153 1152 1154 1215 1201 1196 1195 1194 1193 1192 1191 1190 1106 Probable serine/threonine-protein kinase roco4
AGC PRKCI KPCI_HUMAN 5LI9A P41743 248 589 596.0 ACP:60601 ATPlike Active DFGin 5.635 12.633 BLAminus -139.17, 172.4 72.31, 78.11 -98.86, 1.23 304.03, 143.26 -64.9, -22.84 in-in in 8.361 Saltbr-in 2.614 HRD-in -73.79, -55.22 70.11, -1.11 in-in-in SNCiii in-in ActLoopNT-in 2.81 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.64, 169.55 APE9-dihe-na 127.72, -178.47 APE8-dihe-in -93.25, 127.56 APE8-rot-in 298.81 APE67-dihe-in -60.64, -20.02 -47.28, -45.36 APE12-dist-in 8.812 APE11-dist-in 11.949 APE10-dist-in 6.432 APE9-dist-in 3.836 None TPO412,TPO564 TPO412,TPO564 XRAY 1.79 0.19 0.231 A 350 330 12 0 0 0 [[254, 522]] 1.0 5li9 Homo sapiens AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC RPS6KA1-1 KS6A1_HUMAN 2Z7QA Q15418 56 340 735.0 ACP:500 ATPlike Inactive DFGin 8.028 12.369 BLBplus -135.49, 158.95 63.12, 60.24 -125.42, -165.59 47.01, 74.46 107.04, -8.15 none-none none 999.0 Saltbr-none 999.0 HRD-out -82.53, 70.19 -54.28, -43.87 none-out-out SNCnoo out-out ActLoopNT-out 7.053 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -165.36 APE8-dihe-in -67.18, 106.47 APE8-rot-in 305.06 APE67-dihe-in -59.78, -23.27 -56.13, -39.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.791 None None None XRAY 2.0 0.264 0.283 A 321 255 30 0 0 12 [[62, 321], [418, 675]] 2.0 2z7q Homo sapiens AGC_RPS6KA1-1_HUMAN AGC 1.5e-95 325.1 1 260 260 204 205 206 208 210 94 112 116 184 186 185 187 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
CAMK AURKA AURKA_HUMAN 4C3PD O14965 125 390 403.0 ACP:1391 ATPlike Inactive DFGin 5.08 15.091 ABAminus -119.78, -23.96 -110.92, 146.31 -144.29, 22.56 288.75, 97.88 -63.46, -34.21 out-out out 11.164 Saltbr-out 5.973 HRD-out -75.78, -41.12 71.55, -101.13 out-in-out SNCoio in-out ActLoopNT-in 3.111 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -140.51, -146.18 APE9-dihe-na 83.68, 6.59 APE8-dihe-out -140.3, 13.24 APE8-rot-out 207.12 APE67-dihe-in -44.87, -30.51 -70.19, -27.98 APE12-dist-none 999.0 APE11-dist-out 20.87 APE10-dist-out 24.129 APE9-dist-out 28.582 None None None XRAY 2.69 0.205 0.289 D 282 260 6 0 0 6 [[133, 383]] 1.0 4c3p Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5G15A O14965 126 390 403.0 ACP:1391 ATPlike Inactive DFGin 5.983 16.386 BLAminus -138.69, -169.03 59.87, 67.73 -86.51, 18.94 284.94, 72.05 -48.14, -38.59 out-out out 10.296 Saltbr-out 5.173 HRD-in -73.28, -52.04 69.95, 14.4 out-in-in SNCoii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.64, 165.4 APE9-dihe-na 125.58, -148.7 APE8-dihe-in -133.46, 135.34 APE8-rot-in 292.83 APE67-dihe-in -71.67, -13.58 -36.11, -59.51 APE12-dist-in 10.319 APE11-dist-in 11.183 APE10-dist-in 5.61 APE9-dist-in 3.463 None None None XRAY 2.06 0.229 0.274 A 282 265 0 0 0 0 [[133, 383]] 1.0 5g15 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6CPFA O14965 128 392 403.0 ACP:501 ATPlike Inactive DFGin 5.851 16.076 BLAminus -125.44, -173.01 51.86, 75.65 -92.36, 20.23 261.59, 77.98 -63.75, -18.06 out-none out 11.248 Saltbr-none 999.0 HRD-in -104.84, -51.34 76.83, -36.49 none-in-out SNCnio in-out ActLoopNT-in 3.202 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -168.9 APE8-dihe-in -78.28, 136.09 APE8-rot-out 59.9 APE67-dihe-in -54.01, -29.69 -75.21, 5.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.708 None None None XRAY 2.3 0.222 0.259 A 285 259 6 0 0 6 [[133, 383]] 1.0 6cpf Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4C3PA O14965 125 388 403.0 ACP:1389 ATPlike Inactive DFGin 5.121 15.311 None -143.16, 44.14 -117.33, -72.7 63.16, 22.36 309.54, 103.5 -71.05, -27.42 out-out out 10.713 Saltbr-out 4.955 HRD-out -79.39, 150.41 -121.39, -68.05 out-in-out SNCoio in-out ActLoopNT-in 2.819 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -49.34, 122.38 APE9-dihe-na 116.03, -35.9 APE8-dihe-out -100.65, -0.54 APE8-rot-out 177.69 APE67-dihe-in -57.5, -32.82 -45.19, -41.29 APE12-dist-out 20.928 APE11-dist-out 21.176 APE10-dist-out 26.156 APE9-dist-out 28.591 None None None XRAY 2.69 0.205 0.289 A 282 264 0 0 0 0 [[133, 383]] 1.0 4c3p Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4C3RA O14965 127 388 403.0 ACP:1389 ATPlike Inactive DFGinter 6.087 8.639 None -114.31, -7.36 -87.64, 130.6 -72.8, -47.16 285.43, 29.08 69.28, 138.63 out-out out 11.963 Saltbr-out 7.785 HRD-out -148.79, 112.09 -68.12, -80.01 out-out-out SNCooo out-out ActLoopNT-out 8.017 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 137.49 APE8-dihe-in -74.84, 138.8 APE8-rot-out 199.32 APE67-dihe-in -50.64, -36.72 -89.13, -8.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.231 None None None XRAY 2.79 0.229 0.306 A 282 252 10 0 0 10 [[133, 383]] 1.0 4c3r Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6C83B O14965 127 388 403.0 ACP:501 ATPlike Inactive DFGinter 7.317 8.588 None -129.69, 90.85 -100.04, 101.37 -135.34, 999.0 303.1, 99.49 999.0, 999.0 out-out out 12.115 Saltbr-out 10.049 HRD-out -96.09, 116.19 -110.78, 111.97 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -90.23 APE8-dihe-out -77.58, -0.58 APE8-rot-out 85.03 APE67-dihe-in -69.49, -5.14 -61.84, -44.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.472 None None None XRAY 2.55 0.268 0.322 B 285 247 15 0 0 15 [[133, 383]] 1.0 6c83 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6C83A O14965 127 389 403.0 ACP:501 ATPlike Inactive None 999.0 999.0 None -115.58, 146.0 -134.74, 164.64 -155.95, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.294 Saltbr-none 999.0 HRD-out 57.31, 86.65 -118.52, 133.44 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -76.52 APE8-dihe-out -81.29, 5.34 APE8-rot-out 166.86 APE67-dihe-in -68.45, -16.44 -75.67, -23.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.256 None None None XRAY 2.55 0.268 0.322 A 285 248 15 0 0 15 [[133, 383]] 1.0 6c83 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK DAPK1 DAPK1_HUMAN 3ZXTB P53355 7 276 1430.0 ACP:1279 ATPlike None DFGin 6.575 14.067 BLAminus -121.46, -170.78 56.12, 80.76 -103.93, 17.27 282.46, 79.2 -56.39, -19.56 in-in in 8.68 Saltbr-in 2.544 HRD-in -82.72, -41.2 65.14, 3.07 in-in-none SNCiin in-none ActLoopNT-in 2.949 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -71.62 APE8-rot-none 999.0 APE67-dihe-in -62.85, -24.88 -49.25, -41.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 B 285 253 17 0 0 10 [[13, 275]] 1.0 3zxt Homo sapiens CAMK_DAPK1_HUMAN CAMK 5.5e-95 323.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3ZXTC P53355 5 276 1430.0 ACP:1278 ATPlike None DFGin 6.764 14.238 BLAminus -125.03, -178.44 64.54, 79.35 -91.9, 24.57 287.83, 76.0 -66.08, -19.72 in-in in 9.392 Saltbr-in 2.719 HRD-in -72.23, -37.44 57.47, 4.52 in-in-none SNCiin in-none ActLoopNT-in 3.097 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -39.65, -42.12 999.0, -61.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 C 285 259 13 0 0 11 [[13, 275]] 1.0 3zxt Homo sapiens CAMK_DAPK1_HUMAN CAMK 5.5e-95 323.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3ZXTD P53355 7 276 1430.0 ACP:1277 ATPlike None DFGin 6.866 14.645 BLAminus -115.85, 173.32 73.06, 78.3 -92.76, 17.5 283.87, 68.26 -68.46, 25.44 in-in in 9.306 Saltbr-in 2.651 HRD-in -83.16, -46.35 65.92, 13.4 in-in-none SNCiin in-none ActLoopNT-in 3.108 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -20.61 APE8-rot-none 999.0 APE67-dihe-in -90.53, -15.22 -91.11, -7.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 D 285 245 25 0 0 10 [[13, 275]] 1.0 3zxt Homo sapiens CAMK_DAPK1_HUMAN CAMK 5.5e-95 323.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3ZXTA P53355 7 276 1430.0 ACP:1277 ATPlike Inactive DFGin 6.539 14.057 BLBminus -116.48, -174.8 63.15, 89.03 -105.65, -162.71 284.37, 74.81 49.59, 38.57 in-in in 8.914 Saltbr-in 3.208 HRD-in -74.82, -48.06 69.59, 6.45 in-in-none SNCiin in-none ActLoopNT-in 2.725 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -35.07 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 A 285 249 21 0 0 12 [[13, 275]] 1.0 3zxt Homo sapiens CAMK_DAPK1_HUMAN CAMK 5.5e-95 323.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CK1 CSNK1D KC1D_HUMAN 6RU6A P48730 3 294 415.0 ACP:60301 ATPlike Active DFGin 6.436 15.264 BLAminus -136.56, 176.84 69.53, 73.53 -93.66, 24.95 289.84, 81.36 -61.77, -30.96 in-in in 7.923 Saltbr-in 2.789 HRD-in -77.83, -55.12 76.08, 12.52 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.64, 119.59 APE9-dihe-na 102.6, -136.74 APE8-dihe-in -117.46, 127.27 APE8-rot-in 311.09 APE67-dihe-in -57.82, -37.85 -53.66, -47.41 APE12-dist-in 12.315 APE11-dist-in 11.908 APE10-dist-in 6.481 APE9-dist-in 3.505 None None None XRAY 2.05 0.213 0.257 A 296 288 4 0 0 0 [[9, 275]] 1.0 6ru6 Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU6B P48730 3 294 415.0 ACP:60301 ATPlike None DFGin 6.59 15.156 BLAminus -129.63, 177.25 73.9, 71.28 -92.31, 21.27 283.76, 74.29 -58.84, -31.38 in-in in 7.818 Saltbr-in 2.796 HRD-in -76.32, -55.32 74.02, 14.82 in-in-none SNCiin in-none ActLoopNT-in 2.86 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -126.17 APE8-dihe-in -104.51, 127.76 APE8-rot-in 311.88 APE67-dihe-in -57.59, -35.09 -58.93, -44.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.941 None None None XRAY 2.05 0.213 0.257 B 296 278 14 0 0 8 [[9, 275]] 1.0 6ru6 Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CMGC CSNK2A1 CSK21_HUMAN 4NH1A P68400 3 332 391.0 ACP:403 ATPlike Inactive DFGin 7.539 16.051 BLAminus -114.39, -169.88 57.86, 83.41 -112.16, 31.33 299.65, 85.49 -75.44, -39.86 in-in in 9.278 Saltbr-in 2.773 HRD-in -89.66, -46.45 59.34, 26.3 in-in-out SNCiio in-out ActLoopNT-in 2.903 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.56, 170.73 APE9-dihe-na 63.23, 162.58 APE8-dihe-in -68.16, 150.73 APE8-rot-out 180.05 APE67-dihe-in -73.61, -11.12 -57.46, -41.94 APE12-dist-in 12.715 APE11-dist-in 10.529 APE10-dist-in 6.058 APE9-dist-in 3.323 None None None XRAY 3.3 0.215 0.251 A 335 330 0 0 0 0 [[39, 324]] 1.0 4nh1 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 4NH1B P68400 2 333 391.0 ACP:404 ATPlike Inactive DFGin 7.534 16.001 BLAminus -114.45, -169.84 57.84, 82.99 -112.41, 30.84 300.31, 85.61 -75.38, -39.92 in-in in 9.231 Saltbr-in 2.774 HRD-in -90.12, -46.63 59.22, 26.59 in-in-out SNCiio in-out ActLoopNT-in 2.954 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.21, 170.34 APE9-dihe-na 63.1, 162.47 APE8-dihe-in -68.11, 151.28 APE8-rot-out 180.18 APE67-dihe-in -73.01, -10.91 -57.19, -42.14 APE12-dist-in 12.652 APE11-dist-in 10.528 APE10-dist-in 5.992 APE9-dist-in 3.365 None None None XRAY 3.3 0.215 0.251 B 335 332 0 0 0 0 [[39, 324]] 1.0 4nh1 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC MAPK1 MK01_HUMAN 5V60A P28482 10 358 360.0 ACP:401 ATPlike Active DFGin 6.669 14.887 BLAminus -124.21, -175.27 60.56, 75.29 -91.11, 25.45 286.11, 68.09 -67.4, -23.76 in-in in 9.269 Saltbr-in 3.088 HRD-in -75.88, -52.24 69.24, 12.32 in-in-in SNCiii in-in ActLoopNT-in 2.951 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -89.66, 171.23 APE9-dihe-na 66.7, 168.41 APE8-dihe-in -89.68, 141.19 APE8-rot-in 301.48 APE67-dihe-in -66.12, -19.67 -43.41, -50.15 APE12-dist-in 12.574 APE11-dist-in 11.086 APE10-dist-in 6.633 APE9-dist-in 2.987 None TPO185,PTR187 TPO185,PTR187 XRAY 2.18 0.193 0.226 A 356 349 0 0 0 0 [[25, 313]] 1.0 5v60 Homo sapiens CMGC_MAPK1_HUMAN CMGC 8.8e-86 293.8 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK10 MK10_HUMAN 6EQ9B P53779 47 400 464.0 ACP:502 ATPlike Inactive DFGin 3.849 14.536 ABAminus -85.08, -18.98 -157.51, 177.19 -105.91, 17.98 303.5, 84.3 71.4, -149.1 in-in in 9.644 Saltbr-in 2.882 HRD-in -75.97, -57.51 71.23, 0.13 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 107.58 APE8-dihe-in -64.66, 120.8 APE8-rot-in 307.67 APE67-dihe-in -65.89, -19.34 -114.84, 1.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.043 None None None XRAY 1.83 0.207 0.252 B 367 332 14 0 0 14 [[64, 359]] 1.0 6eq9 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 6EQ9A P53779 46 400 464.0 ACP:505,C15:506 ATPlike,Allosteric Inactive DFGin 3.763 14.179 ABAminus -90.84, -25.71 -146.46, -174.02 -119.81, 8.04 305.39, 99.67 64.39, -162.69 in-out in 9.653 Saltbr-out 3.917 HRD-in -74.99, -56.85 72.96, -15.02 out-out-out SNCooo out-out ActLoopNT-out 6.285 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -45.37 APE8-dihe-in -112.64, 106.03 APE8-rot-in 290.72 APE67-dihe-in -70.8, -9.5 -110.9, 2.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.517 None None None XRAY 1.83 0.207 0.252 A 367 350 5 0 0 5 [[64, 359]] 1.0 6eq9 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 8VTFA P53779 45 400 464.0 A1ACP:1101 Type1 Inactive DFGin 4.123 14.437 ABAminus -80.88, -55.79 -105.49, 178.52 -116.12, 4.6 292.24, 108.11 97.34, -165.3 out-out out 10.177 Saltbr-out 6.059 HRD-in -81.08, -68.87 73.64, -1.6 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -88.73, 154.5 APE9-dihe-na -85.68, 161.75 APE8-dihe-in -104.45, 122.83 APE8-rot-in 288.76 APE67-dihe-in -66.26, -13.42 -118.39, 6.09 APE12-dist-out 21.204 APE11-dist-out 17.128 APE10-dist-out 16.367 APE9-dist-out 11.624 None None None XRAY 2.4 0.258 0.297 A 464 346 5 0 0 5 [[64, 359]] 1.0 8vtf Homo sapiens CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
OTHER RNASEL RN5A_HUMAN 4OAVB Q05823 24 717 741.0 ACP:801 ATPlike Pseudo DFGin 6.475 12.367 BLAminus -139.92, -178.5 65.74, 91.26 -114.98, 14.68 309.18, 101.1 -77.21, 3.69 in-in in 6.905 Saltbr-in 2.74 HRD-in -87.38, -45.25 69.13, -2.14 in-in-na SNCiia in-na ActLoopNT-in 3.06 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.56, 102.63 APE9-dihe-na -56.52, -19.13 APE8-dihe-na -66.25, -31.04 APE8-rot-na 198.81 APE67-dihe-na -66.21, -44.37 -71.69, -39.0 APE12-dist-na 15.293 APE11-dist-na 17.012 APE10-dist-na 15.02 APE9-dist-na 14.396 H672N None None XRAY 2.1 0.2 0.229 B 699 673 8 0 0 0 [[353, 594]] 1.0 4oav Homo sapiens OTHER_RNASEL_HUMAN RNASEL 4.1e-136 459.9 1 242 242 502 503 504 506 508 392 404 408 482 484 483 485 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
OTHER RNASEL RN5A_HUMAN 4OAVD Q05823 26 719 741.0 ACP:1001 ATPlike Pseudo DFGin 6.559 12.405 BLAminus -138.71, -178.08 64.72, 95.25 -118.8, 14.99 306.98, 96.56 -77.32, 4.45 in-in in 6.904 Saltbr-in 2.919 HRD-in -73.82, -49.38 73.22, -2.68 in-in-na SNCiia in-na ActLoopNT-in 2.915 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.59, 112.49 APE9-dihe-na -62.01, -29.18 APE8-dihe-na -62.89, -32.55 APE8-rot-na 188.49 APE67-dihe-na -70.07, -38.9 -67.42, -39.34 APE12-dist-na 14.651 APE11-dist-na 16.869 APE10-dist-na 14.635 APE9-dist-na 14.352 H672N None None XRAY 2.1 0.2 0.229 D 699 674 7 0 0 0 [[353, 594]] 1.0 4oav Homo sapiens OTHER_RNASEL_HUMAN RNASEL 4.1e-136 459.9 1 242 242 502 503 504 506 508 392 404 408 482 484 483 485 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
STE MAP2K1 MP2K1_HUMAN 6U2GA Q02750 43 383 393.0 ACP:901 ATPlike Inactive DFGin 5.808 13.841 BLBplus -143.7, 174.8 53.7, 47.78 -98.62, 156.52 46.78, 97.62 -76.59, 70.13 out-out out 15.374 Saltbr-out 14.869 HRD-in -83.28, -55.76 76.37, -10.26 out-out-out SNCooo out-out ActLoopNT-out 9.207 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -64.24, 146.48 APE9-dihe-na -101.23, -173.03 APE8-dihe-out -114.34, -9.62 APE8-rot-out 55.71 APE67-dihe-out -148.86, 141.69 -149.81, 176.75 APE12-dist-out 19.186 APE11-dist-out 17.982 APE10-dist-out 22.105 APE9-dist-out 13.0 None None None XRAY 2.886 0.231 0.276 A 394 309 32 0 0 0 [[68, 361]] 1.0 6u2g Homo sapiens STE_MAP2K1_HUMAN STE 2.4e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNEA Q02750 63 379 393.0 ACP:901,573:903 ATPlike,Type1 Inactive DFGin 6.382 13.69 BLBplus -140.61, 176.72 54.72, 28.13 -81.46, 161.59 52.56, 86.0 -81.78, 73.09 out-out out 15.497 Saltbr-out 15.779 HRD-in -64.01, -56.53 90.31, -35.13 out-out-out SNCooo out-out ActLoopNT-out 9.29 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -73.66, 137.78 APE9-dihe-na -84.79, 178.97 APE8-dihe-out -113.02, -24.38 APE8-rot-out 49.94 APE67-dihe-out -153.46, 146.56 -142.39, -172.52 APE12-dist-out 17.192 APE11-dist-out 21.653 APE10-dist-out 23.798 APE9-dist-out 13.497 None None None XRAY 2.848 0.186 0.24 A 341 286 31 0 0 0 [[68, 361]] 1.0 4mne Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNED Q02750 66 382 393.0 ACP:901,573:903 ATPlike,Type1 Inactive DFGin 6.263 13.873 BLBplus -124.78, 174.1 56.33, 33.25 -88.39, 154.28 50.46, 89.74 -73.02, 74.09 out-out out 15.538 Saltbr-out 15.614 HRD-in -64.9, -49.38 74.62, -12.51 out-out-out SNCooo out-out ActLoopNT-out 9.043 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -65.65, 150.79 APE9-dihe-na -95.28, -163.25 APE8-dihe-out -122.75, -11.87 APE8-rot-out 68.42 APE67-dihe-out -159.06, 142.59 -161.08, -176.92 APE12-dist-out 17.403 APE11-dist-out 21.784 APE10-dist-out 23.852 APE9-dist-out 13.632 None None None XRAY 2.848 0.186 0.24 D 341 285 32 0 0 0 [[68, 361]] 1.0 4mne Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4AN9A Q02750 61 381 393.0 ACP:61382,2P7:61384 ATPlike,Type3 Inactive DFGin 6.311 13.752 BLBplus -147.68, 174.84 72.25, 33.73 -84.91, 163.57 42.25, 107.87 -96.68, 81.85 out-out out 15.688 Saltbr-out 15.109 HRD-in -67.38, -51.77 90.36, -23.63 out-out-out SNCooo out-out ActLoopNT-out 9.417 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_onoo APE10-dihe-na 999.0, 140.8 APE9-dihe-na -91.12, -166.68 APE8-dihe-in -63.03, 65.46 APE8-rot-in 350.49 APE67-dihe-in -61.1, -23.55 -42.53, -42.27 APE12-dist-out 17.626 APE11-dist-none 999.0 APE10-dist-out 19.703 APE9-dist-out 7.857 S218E,S222E,G328A None None XRAY 2.8 0.205 0.313 A 301 278 1 0 0 1 [[68, 361]] 1.0 4an9 Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNEE Q02750 62 379 393.0 ACP:901,573:903 ATPlike,Type3 Inactive DFGin 6.301 13.741 BLBplus -139.17, 176.14 61.58, 40.21 -96.23, 153.1 47.97, 96.35 -69.87, 64.71 out-out out 15.796 Saltbr-out 16.157 HRD-in -84.17, -39.22 69.48, -27.4 out-out-out SNCooo out-out ActLoopNT-out 9.277 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -76.04, 124.0 APE9-dihe-na -78.04, -178.79 APE8-dihe-out -111.0, -36.1 APE8-rot-out 69.56 APE67-dihe-out -140.43, 146.63 -132.48, 167.21 APE12-dist-out 17.663 APE11-dist-out 21.775 APE10-dist-out 24.237 APE9-dist-out 13.553 None None None XRAY 2.848 0.186 0.24 E 341 286 32 0 0 0 [[68, 361]] 1.0 4mne Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNEH Q02750 66 380 393.0 ACP:901,573:903,573:904 ATPlike,Type3,Allosteric Inactive DFGin 6.378 13.891 BLBplus -149.03, 175.24 52.75, 36.33 -93.4, 157.98 53.98, 84.28 -78.54, 56.84 out-out out 15.815 Saltbr-out 15.456 HRD-in -72.48, -51.28 80.05, -1.12 out-out-out SNCooo out-out ActLoopNT-out 9.111 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -63.87, 146.83 APE9-dihe-na -98.86, 164.39 APE8-dihe-out -71.61, -59.39 APE8-rot-in 294.12 APE67-dihe-out -156.42, 156.79 -128.0, -169.25 APE12-dist-out 17.747 APE11-dist-out 21.888 APE10-dist-out 24.157 APE9-dist-out 13.665 None None None XRAY 2.848 0.186 0.24 H 341 275 40 0 0 0 [[68, 361]] 1.0 4mne Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4AN2A Q02750 61 381 393.0 EUI:61382,ACP:61383 Type3,ATPlike Inactive DFGin 6.506 13.62 BLBplus -122.79, 178.99 56.84, 40.15 -92.39, 167.6 39.23, 93.66 -89.21, 72.99 out-out out 15.447 Saltbr-out 15.276 HRD-in -67.56, -54.42 79.08, -11.1 out-out-out SNCooo out-out ActLoopNT-out 9.035 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -98.27, 63.09 APE9-dihe-na -45.72, -71.67 APE8-dihe-in -89.8, 67.42 APE8-rot-out 5.41 APE67-dihe-in -66.45, -14.82 -49.39, -42.64 APE12-dist-out 17.474 APE11-dist-out 16.559 APE10-dist-out 17.03 APE9-dist-out 8.716 S218E,S222E,G328A None None XRAY 2.5 0.215 0.299 A 301 279 0 0 0 0 [[68, 361]] 1.0 4an2 Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4ANBA Q02750 61 381 393.0 YQY:60501,ACP:60502 Type3,ATPlike Inactive DFGin 6.358 13.393 BLBplus -107.54, 172.13 64.32, 39.17 -93.81, 160.33 38.34, 94.07 -83.38, 74.0 out-out out 15.224 Saltbr-out 14.817 HRD-in -75.33, -47.65 77.84, -16.31 out-out-out SNCooo out-out ActLoopNT-out 9.414 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -89.14, -39.83 APE9-dihe-na 89.67, -158.68 APE8-dihe-in -87.88, 72.09 APE8-rot-out 15.75 APE67-dihe-in -64.72, -18.82 -69.34, -22.58 APE12-dist-out 17.552 APE11-dist-out 16.893 APE10-dist-out 19.841 APE9-dist-out 8.65 S218E,S222E,G328A None None XRAY 2.2 0.23 0.296 A 301 279 0 0 0 0 [[68, 361]] 1.0 4anb Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
TKL BRAF BRAF_HUMAN 6U2GB P15056 451 722 766.0 ACP:901 ATPlike Inactive DFGin 6.15 13.909 BLBplus -127.14, -173.09 46.65, 53.2 -113.93, 152.92 52.73, 94.7 72.25, -152.99 out-out out 14.606 Saltbr-out 12.705 HRD-in -59.19, -53.53 76.48, -9.73 out-out-out SNCooo out-out ActLoopNT-out 9.495 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -146.07, 161.59 APE9-dihe-na 90.18, -141.72 APE8-dihe-in -101.38, 139.04 APE8-rot-out 180.97 APE67-dihe-in -60.58, -31.67 -70.85, -22.56 APE12-dist-out 15.336 APE11-dist-out 15.709 APE10-dist-out 13.592 APE9-dist-out 9.892 None None None XRAY 2.886 0.231 0.276 B 307 264 8 0 0 8 [[457, 716]] 1.0 6u2g Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL RIPK2 RIPK2_HUMAN 5NG0A O43353 6 300 540.0 ACP:1000 ATPlike Inactive DFGin 5.878 14.178 BLAminus -123.27, -179.27 62.78, 77.58 -93.4, 20.77 286.94, 75.81 -61.85, -28.6 in-in in 8.205 Saltbr-in 2.745 HRD-in -73.28, -52.62 66.02, 10.49 in-in-out SNCiio in-out ActLoopNT-in 2.847 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 157.46 APE8-dihe-in -72.18, 143.02 APE8-rot-out 185.7 APE67-dihe-in -65.61, -24.81 -104.28, 1.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8 L294F None None XRAY 2.0 0.171 0.191 A 304 274 21 0 0 15 [[18, 292]] 1.0 5ng0 Homo sapiens TKL_RIPK2_HUMAN TKL 4.1e-73 252.1 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5NG0B O43353 5 299 540.0 ACP:401 ATPlike Inactive DFGin 5.887 14.177 BLAminus -123.03, -178.96 62.29, 77.78 -94.31, 21.44 286.41, 77.58 -63.12, -27.82 in-in in 8.16 Saltbr-in 2.756 HRD-in -74.08, -51.77 69.59, 3.54 in-in-out SNCiio in-out ActLoopNT-in 2.853 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -72.33, -175.56 APE9-dihe-na 154.16, -172.85 APE8-dihe-in -105.14, 130.27 APE8-rot-in 300.55 APE67-dihe-in -61.64, -28.91 -51.09, -46.77 APE12-dist-in 11.85 APE11-dist-out 7.402 APE10-dist-in 6.02 APE9-dist-in 3.342 L294F None None XRAY 2.0 0.171 0.191 B 304 282 13 0 0 10 [[18, 292]] 1.0 5ng0 Homo sapiens TKL_RIPK2_HUMAN TKL 4.1e-73 252.1 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5AR3A O43353 6 310 540.0 ACP:1311 ATPlike Inactive DFGin 5.924 14.288 BLAminus -133.03, 175.56 72.21, 76.24 -97.68, 34.32 293.9, 86.68 -66.76, -37.47 in-in in 7.994 Saltbr-in 2.8 HRD-in -61.0, -40.82 51.84, 8.75 in-in-out SNCiio in-out ActLoopNT-in 2.841 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -117.65 APE9-dihe-na 164.28, -57.84 APE8-dihe-in -114.77, 107.38 APE8-rot-out 185.6 APE67-dihe-in -64.24, -32.65 -95.4, 6.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.709 APE9-dist-out 10.828 None None None XRAY 3.23 0.192 0.254 A 326 279 26 0 0 14 [[18, 292]] 1.0 5ar3 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5AR3B O43353 6 310 540.0 ACP:1311 ATPlike Inactive DFGin 5.87 14.418 BLAminus -128.31, 176.09 65.92, 78.1 -98.91, 35.33 294.64, 70.55 -68.55, -48.71 in-in in 8.021 Saltbr-in 2.88 HRD-in -65.19, -46.65 55.58, 8.54 in-in-out SNCiio in-out ActLoopNT-in 2.861 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.98 APE8-rot-out 49.06 APE67-dihe-in -39.82, -41.25 -97.08, -7.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.23 0.192 0.254 B 326 276 29 0 0 16 [[18, 292]] 1.0 5ar3 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4 266 263 163 164 165 167 169 47 66 70 143 145 144 146 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TYR EPHA2 EPHA2_HUMAN 7KJAB P29317 590 965 976.0 ACP:61003 ATPlike None DFGin 5.95 15.319 BLAminus -132.83, -173.32 70.39, 83.56 -118.78, 24.56 302.85, 98.09 -89.22, 999.0 in-in in 8.607 Saltbr-in 3.165 HRD-in -76.56, -48.38 78.92, -16.95 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.75 APE8-rot-na 32.08 APE67-dihe-in -69.28, -11.58 -65.6, -29.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.19 0.217 B 390 349 22 0 0 20 [[613, 873]] 1.0 7kja Homo sapiens TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 7KJCA P29317 590 976 976.0 ACP:61001 ATPlike Inactive DFGin 5.878 14.93 BLBminus -137.77, -170.41 70.81, 83.37 -119.58, 163.56 301.23, 100.14 146.26, -161.86 in-in in 8.355 Saltbr-in 3.032 HRD-in -75.87, -47.34 76.1, -11.46 in-out-none SNCion out-none ActLoopNT-out 9.669 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 107.51 APE9-dihe-in -145.96, 148.03 APE8-dihe-in -73.29, 89.61 APE8-rot-na 29.38 APE67-dihe-in -67.75, -13.33 -62.67, -32.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.547 APE9-dist-in 6.64 S901E None None XRAY 2.3 0.19 0.226 A 390 373 8 0 0 5 [[613, 873]] 1.0 7kjc Homo sapiens TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 7KJCB P29317 590 965 976.0 ACP:61002 ATPlike Inactive DFGin 5.963 15.204 BLBminus -132.91, -166.6 60.51, 83.21 -117.48, 163.92 299.39, 100.57 145.47, 999.0 in-in in 8.467 Saltbr-in 3.13 HRD-in -75.7, -46.49 74.32, -9.38 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 86.32 APE8-rot-na 29.03 APE67-dihe-in -66.96, -12.86 -66.13, -32.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 S901E None None XRAY 2.3 0.19 0.226 B 390 347 23 0 0 20 [[613, 873]] 1.0 7kjc Homo sapiens TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 7KJAA P29317 590 976 976.0 ACP:61002 ATPlike Inactive DFGin 5.763 14.769 BLBminus -129.59, -174.19 75.99, 88.0 -122.87, 170.51 304.47, 101.43 99.06, 999.0 in-in in 8.424 Saltbr-in 3.055 HRD-in -76.77, -48.29 79.69, -17.22 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.1 APE8-rot-na 32.23 APE67-dihe-in -70.25, -11.59 -65.39, -29.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.19 0.217 A 390 361 20 0 0 20 [[613, 873]] 1.0 7kja Homo sapiens TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR FGFR1 FGFR1_HUMAN 3GQIA P11362 464 770 822.0 ACP:775 ATPlike Active DFGin 6.466 13.946 BLAminus -126.61, -175.83 60.19, 72.36 -91.08, 18.42 288.73, 91.63 -64.67, -15.4 in-in in 7.751 Saltbr-in 2.69 HRD-in -77.5, -49.87 72.48, -2.68 in-in-in SNCiii in-in ActLoopNT-in 2.961 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.96, 135.34 APE9-dihe-in -149.19, 136.62 APE8-dihe-in -75.51, 66.48 APE8-rot-na 33.4 APE67-dihe-in -65.08, -11.82 -44.91, -41.18 APE12-dist-na 14.083 APE11-dist-na 11.258 APE10-dist-na 10.128 APE9-dist-in 7.137 C488A,Y583F,C584S,Y585F PTR653,PTR654,PTR766 PTR653,PTR654,PTR766 XRAY 2.5 0.249 0.289 A 326 307 0 0 0 0 [[478, 756]] 1.0 3gqi Homo sapiens TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR2 FGFR2_HUMAN 2PWLA P21802 467 764 821.0 ACP:300 ATPlike Inactive DFGin 6.451 14.178 BLAminus -131.61, -167.38 56.51, 73.64 -92.98, 26.06 293.6, 74.93 -63.45, -20.7 in-in in 7.586 Saltbr-in 2.856 HRD-in -77.4, -49.09 71.28, -7.85 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.03, 20.75 APE9-dihe-in -94.74, 135.38 APE8-dihe-in -58.69, 123.68 APE8-rot-na 326.81 APE67-dihe-in -69.99, -5.92 -52.74, -45.54 APE12-dist-na 10.002 APE11-dist-na 10.678 APE10-dist-na 7.432 APE9-dist-in 4.749 C491A,N549H None None XRAY 2.4 0.21 0.238 A 324 284 14 0 0 0 [[481, 759]] 1.0 2pwl Homo sapiens TYR_FGFR2_HUMAN TYR 3.1e-104 353.8 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PWLB P21802 468 765 821.0 ACP:300 ATPlike Inactive DFGin 6.439 14.28 BLAminus -131.94, -168.62 54.17, 75.02 -93.02, 25.01 292.99, 76.23 -61.28, -25.59 in-in in 7.692 Saltbr-in 3.07 HRD-in -69.87, -47.96 69.48, -8.93 in-in-out SNCiio in-out ActLoopNT-in 2.916 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.23, 16.85 APE9-dihe-in -95.43, 136.0 APE8-dihe-in -55.13, 121.27 APE8-rot-na 324.13 APE67-dihe-in -66.61, -7.86 -55.94, -44.16 APE12-dist-na 10.089 APE11-dist-na 10.854 APE10-dist-na 7.485 APE9-dist-in 4.912 C491A,N549H None None XRAY 2.4 0.21 0.238 B 324 286 12 0 0 0 [[481, 759]] 1.0 2pwl Homo sapiens TYR_FGFR2_HUMAN TYR 3.1e-104 353.8 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J96B P21802 462 766 821.0 ACP:803 ATPlike Inactive DFGin 6.422 14.069 BLAminus -135.07, -171.17 49.96, 77.75 -93.13, 20.28 283.65, 85.2 -66.67, -18.8 in-out in 7.205 Saltbr-out 3.691 HRD-in -86.85, -47.88 76.0, -13.66 out-in-out SNCoio in-out ActLoopNT-in 2.811 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.69, 28.85 APE9-dihe-in -99.38, 128.67 APE8-dihe-in -54.56, 125.51 APE8-rot-na 329.88 APE67-dihe-in -70.35, -5.29 -58.48, -39.96 APE12-dist-na 14.724 APE11-dist-na 10.154 APE10-dist-na 7.507 APE9-dist-in 4.93 C491A,K659M None None XRAY 2.297 0.178 0.219 B 324 305 0 0 0 0 [[481, 759]] 1.0 4j96 Homo sapiens TYR_FGFR2_HUMAN TYR 2.7e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J98B P21802 461 764 821.0 ACP:804 ATPlike Inactive DFGin 6.55 14.042 BLAminus -130.09, -172.54 52.51, 78.98 -94.32, 21.96 285.07, 86.18 -63.61, -22.45 in-in in 7.113 Saltbr-in 3.017 HRD-in -86.21, -48.16 74.7, -12.01 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.22, 26.63 APE9-dihe-in -99.48, 124.84 APE8-dihe-in -50.97, 125.51 APE8-rot-na 328.99 APE67-dihe-in -68.16, -7.57 -60.28, -41.11 APE12-dist-na 15.096 APE11-dist-na 10.418 APE10-dist-na 7.58 APE9-dist-in 4.827 C491A,K659Q None None XRAY 2.307 0.19 0.234 B 324 304 0 0 0 0 [[481, 759]] 1.0 4j98 Homo sapiens TYR_FGFR2_HUMAN TYR 2.1e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVFA P21802 467 765 821.0 ACP:60300 ATPlike Active DFGin 6.048 13.821 BLAminus -138.88, -175.17 54.67, 80.46 -90.11, 24.33 291.08, 76.38 -54.38, -36.38 in-in in 7.913 Saltbr-in 2.769 HRD-in -85.37, -48.4 70.03, 0.26 in-in-in SNCiii in-in ActLoopNT-in 2.879 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.94, 115.27 APE9-dihe-in -125.87, 160.91 APE8-dihe-in -74.41, 68.1 APE8-rot-na 35.92 APE67-dihe-in -70.82, -9.54 -47.44, -41.99 APE12-dist-na 15.14 APE11-dist-na 11.649 APE10-dist-na 11.604 APE9-dist-in 7.168 C491A PTR586,PTR656,PTR657 PTR586,PTR656,PTR657 XRAY 1.8 0.251 0.265 A 334 288 11 0 0 0 [[481, 759]] 1.0 2pvf Homo sapiens TYR_FGFR2_HUMAN TYR 2.2e-104 354.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 3CLYA P21802 468 772 821.0 ACP:61803 ATPlike Active DFGin 6.229 14.183 BLAminus -138.78, -172.76 51.4, 79.79 -91.29, 32.46 290.47, 75.81 -61.86, -29.26 in-in in 7.661 Saltbr-in 2.621 HRD-in -89.86, -45.92 68.93, -0.84 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.79, 139.96 APE9-dihe-in -131.36, 152.18 APE8-dihe-in -76.17, 66.16 APE8-rot-na 37.1 APE67-dihe-in -66.78, -6.73 -47.95, -40.48 APE12-dist-na 13.253 APE11-dist-na 10.402 APE10-dist-na 11.097 APE9-dist-in 6.913 C491A PTR656,PTR657 PTR656,PTR657 XRAY 2.0 0.216 0.247 A 334 291 14 0 0 0 [[481, 759]] 1.0 3cly Homo sapiens TYR_FGFR2_HUMAN TYR 2.2e-104 354.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J99A P21802 466 764 821.0 ACP:802 ATPlike Inactive DFGin 6.715 14.14 BLAminus -130.96, -174.69 58.83, 77.45 -92.73, 19.29 291.78, 87.39 -60.03, -34.11 in-in in 7.61 Saltbr-in 2.845 HRD-in -78.19, -48.52 73.01, -4.76 in-in-out SNCiio in-out ActLoopNT-in 2.861 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.36, 29.03 APE9-dihe-in -109.75, 138.54 APE8-dihe-in -57.3, 116.33 APE8-rot-na 330.48 APE67-dihe-in -70.7, -10.42 -57.47, -40.52 APE12-dist-na 15.04 APE11-dist-na 11.232 APE10-dist-na 7.972 APE9-dist-in 5.13 C491A,K659T None None XRAY 1.847 0.206 0.24 A 324 280 19 0 0 4 [[481, 759]] 1.0 4j99 Homo sapiens TYR_FGFR2_HUMAN TYR 2e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J99B P21802 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.666 14.188 BLAminus -133.21, -176.0 58.56, 76.97 -94.04, 15.78 292.83, 99.53 -58.91, -32.83 in-in in 7.584 Saltbr-in 2.616 HRD-in -76.65, -48.86 73.31, -6.92 in-in-out SNCiio in-out ActLoopNT-in 2.9 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -118.89, 30.62 APE9-dihe-in -108.84, 137.25 APE8-dihe-in -57.12, 118.19 APE8-rot-na 330.19 APE67-dihe-in -70.1, -10.12 -57.01, -39.76 APE12-dist-na 14.148 APE11-dist-na 11.074 APE10-dist-na 8.007 APE9-dist-in 5.18 C491A,K659T None None XRAY 1.847 0.206 0.24 B 324 291 7 0 0 0 [[481, 759]] 1.0 4j99 Homo sapiens TYR_FGFR2_HUMAN TYR 2e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J99C P21802 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.835 14.168 BLAminus -131.87, -175.54 59.17, 75.71 -91.42, 19.92 291.67, 85.71 -59.92, -32.59 in-in in 7.628 Saltbr-in 2.913 HRD-in -76.88, -47.72 74.23, -7.36 in-in-out SNCiio in-out ActLoopNT-in 2.894 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.66, 30.6 APE9-dihe-in -110.19, 138.06 APE8-dihe-in -55.44, 118.46 APE8-rot-na 330.51 APE67-dihe-in -70.73, -10.29 -57.12, -38.65 APE12-dist-na 14.121 APE11-dist-na 10.954 APE10-dist-na 8.05 APE9-dist-in 5.362 C491A,K659T None None XRAY 1.847 0.206 0.24 C 324 291 7 0 0 0 [[481, 759]] 1.0 4j99 Homo sapiens TYR_FGFR2_HUMAN TYR 2e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J99D P21802 465 764 821.0 ACP:802 ATPlike Inactive DFGin 6.593 14.159 BLAminus -133.66, -174.57 58.72, 78.56 -92.61, 20.44 290.96, 82.99 -59.4, -33.38 in-in in 7.631 Saltbr-in 2.639 HRD-in -78.38, -50.11 73.68, -6.22 in-in-out SNCiio in-out ActLoopNT-in 2.893 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.76, 31.03 APE9-dihe-in -108.34, 137.61 APE8-dihe-in -55.35, 118.06 APE8-rot-na 330.85 APE67-dihe-in -71.9, -11.56 -55.67, -38.95 APE12-dist-na 999.0 APE11-dist-na 11.135 APE10-dist-na 7.859 APE9-dist-in 4.992 C491A,K659T None None XRAY 1.847 0.206 0.24 D 324 281 19 0 0 3 [[481, 759]] 1.0 4j99 Homo sapiens TYR_FGFR2_HUMAN TYR 2e-104 354.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVYA P21802 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.75 14.274 BLAminus -142.14, -176.01 63.9, 72.69 -96.2, 30.01 293.76, 86.07 -65.9, -30.73 in-in in 7.547 Saltbr-in 2.852 HRD-in -84.99, -48.7 74.29, -16.98 in-in-out SNCiio in-out ActLoopNT-in 2.809 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.15, 32.71 APE9-dihe-in -103.67, 126.67 APE8-dihe-in -51.63, 122.63 APE8-rot-na 323.69 APE67-dihe-in -64.04, -12.74 -56.98, -40.88 APE12-dist-na 14.814 APE11-dist-na 10.095 APE10-dist-na 7.537 APE9-dist-in 4.955 C491A,K659N None None XRAY 2.2 0.236 0.276 A 324 288 10 0 0 0 [[481, 759]] 1.0 2pvy Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVYB P21802 462 764 821.0 ACP:8002 ATPlike Inactive DFGin 6.635 14.065 BLAminus -144.27, -177.95 57.14, 77.78 -93.97, 24.89 293.34, 84.21 -55.49, -34.1 in-in in 7.316 Saltbr-in 2.847 HRD-in -81.21, -48.71 71.97, -12.52 in-in-out SNCiio in-out ActLoopNT-in 2.852 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.68, 30.22 APE9-dihe-in -107.46, 135.49 APE8-dihe-in -57.98, 120.91 APE8-rot-na 329.38 APE67-dihe-in -64.69, -5.42 -51.47, -46.8 APE12-dist-na 999.0 APE11-dist-na 10.694 APE10-dist-na 7.435 APE9-dist-in 5.066 C491A,K659N None None XRAY 2.2 0.236 0.276 B 324 286 17 0 0 6 [[481, 759]] 1.0 2pvy Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVYC P21802 462 764 821.0 ACP:802 ATPlike Inactive DFGin 6.693 14.018 BLAminus -131.41, -174.32 49.42, 82.58 -94.81, 27.78 293.52, 79.4 -60.72, -24.91 in-in in 7.229 Saltbr-in 3.577 HRD-in -81.5, -47.6 72.07, -14.53 in-in-out SNCiio in-out ActLoopNT-in 2.794 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.89, 24.55 APE9-dihe-in -101.87, 134.03 APE8-dihe-in -55.3, 120.87 APE8-rot-na 330.19 APE67-dihe-in -64.04, -6.89 -51.83, -46.76 APE12-dist-na 14.316 APE11-dist-na 10.323 APE10-dist-na 7.438 APE9-dist-in 5.069 C491A,K659N None None XRAY 2.2 0.236 0.276 C 324 285 18 0 0 5 [[481, 759]] 1.0 2pvy Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVYD P21802 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.944 14.261 BLAminus -139.76, -174.3 61.15, 74.17 -97.41, 31.68 293.81, 79.18 -66.75, -30.92 in-in in 7.298 Saltbr-in 3.036 HRD-in -85.65, -49.02 75.46, -18.01 in-in-out SNCiio in-out ActLoopNT-in 2.811 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.37, 33.11 APE9-dihe-in -102.8, 126.29 APE8-dihe-in -51.84, 123.89 APE8-rot-na 324.49 APE67-dihe-in -63.66, -13.12 -61.69, -37.66 APE12-dist-na 14.828 APE11-dist-na 10.092 APE10-dist-na 7.57 APE9-dist-in 4.968 C491A,K659N None None XRAY 2.2 0.236 0.276 D 324 283 15 0 0 0 [[481, 759]] 1.0 2pvy Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J95A P21802 467 764 821.0 ACP:801 ATPlike Inactive DFGin 6.691 14.058 BLAminus -131.56, -174.19 63.25, 76.63 -98.25, 22.24 292.31, 85.68 -64.6, -23.3 in-in in 7.752 Saltbr-in 2.811 HRD-in -79.93, -52.54 74.87, -4.09 in-in-out SNCiio in-out ActLoopNT-in 2.992 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.79, 21.67 APE9-dihe-in -99.53, 131.21 APE8-dihe-in -54.93, 120.24 APE8-rot-na 331.68 APE67-dihe-in -73.86, -8.05 -61.39, -39.09 APE12-dist-na 14.773 APE11-dist-na 10.953 APE10-dist-na 7.48 APE9-dist-in 4.867 C491A,K659N None None XRAY 2.377 0.214 0.255 A 324 279 19 0 0 4 [[481, 759]] 1.0 4j95 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J95B P21802 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.677 14.378 BLAminus -131.79, -176.38 62.78, 77.42 -96.59, 21.6 290.19, 86.46 -65.99, -23.31 in-in in 7.797 Saltbr-in 2.903 HRD-in -80.06, -52.15 74.05, -5.91 in-in-out SNCiio in-out ActLoopNT-in 2.897 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.95, 20.73 APE9-dihe-in -101.19, 131.88 APE8-dihe-in -53.9, 121.25 APE8-rot-na 331.03 APE67-dihe-in -73.96, -6.54 -59.67, -39.95 APE12-dist-na 14.977 APE11-dist-na 11.021 APE10-dist-na 7.709 APE9-dist-in 4.856 C491A,K659N None None XRAY 2.377 0.214 0.255 B 324 282 15 0 0 0 [[481, 759]] 1.0 4j95 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J95C P21802 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.762 14.317 BLAminus -132.19, -176.54 63.57, 76.14 -98.34, 23.39 290.03, 85.39 -65.87, -22.89 in-in in 7.736 Saltbr-in 2.825 HRD-in -79.64, -52.73 75.27, -7.0 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.5, 23.85 APE9-dihe-in -97.28, 128.27 APE8-dihe-in -54.92, 121.79 APE8-rot-na 330.61 APE67-dihe-in -73.19, -7.42 -60.17, -39.19 APE12-dist-na 14.732 APE11-dist-na 10.365 APE10-dist-na 7.413 APE9-dist-in 4.906 C491A,K659N None None XRAY 2.377 0.214 0.255 C 324 281 16 0 0 0 [[481, 759]] 1.0 4j95 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J95D P21802 467 764 821.0 ACP:801 ATPlike Inactive DFGin 6.601 14.074 BLAminus -131.84, -175.28 62.91, 77.06 -96.79, 22.82 289.52, 85.1 -64.56, -22.95 in-in in 7.641 Saltbr-in 2.747 HRD-in -80.37, -53.3 74.73, -6.2 in-in-out SNCiio in-out ActLoopNT-in 3.033 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.03, 23.13 APE9-dihe-in -98.93, 130.46 APE8-dihe-in -52.66, 122.62 APE8-rot-na 330.72 APE67-dihe-in -75.07, -8.74 -59.5, -40.3 APE12-dist-na 999.0 APE11-dist-na 10.804 APE10-dist-na 7.616 APE9-dist-in 4.803 C491A,K659N None None XRAY 2.377 0.214 0.255 D 324 271 27 0 0 11 [[481, 759]] 1.0 4j95 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZ5A P21802 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.27 14.129 BLAminus -134.55, -165.25 46.14, 76.71 -87.82, 24.61 288.3, 73.06 -57.77, -17.99 in-in in 7.376 Saltbr-in 2.72 HRD-in -71.49, -53.18 74.61, -7.33 in-in-out SNCiio in-out ActLoopNT-in 2.954 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.92, 23.05 APE9-dihe-in -100.29, 130.1 APE8-dihe-in -50.24, 116.35 APE8-rot-na 324.43 APE67-dihe-in -70.43, -5.4 -48.06, -44.87 APE12-dist-na 10.162 APE11-dist-na 10.892 APE10-dist-na 7.555 APE9-dist-in 4.83 C491A,N549T None None XRAY 2.4 0.214 0.254 A 324 280 19 0 0 0 [[481, 759]] 1.0 2pz5 Homo sapiens TYR_FGFR2_HUMAN TYR 4.5e-104 353.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZ5B P21802 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.42 14.223 BLAminus -139.02, -170.4 49.42, 74.35 -88.07, 29.83 289.06, 77.09 -65.84, -12.67 in-in in 7.304 Saltbr-in 2.773 HRD-in -68.79, -48.45 71.17, -10.83 in-in-out SNCiio in-out ActLoopNT-in 2.924 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.66, 23.86 APE9-dihe-in -102.44, 130.7 APE8-dihe-in -54.21, 119.21 APE8-rot-na 323.97 APE67-dihe-in -67.2, -7.87 -53.61, -43.12 APE12-dist-na 10.046 APE11-dist-na 10.812 APE10-dist-na 7.393 APE9-dist-in 4.981 C491A,N549T None None XRAY 2.4 0.214 0.254 B 324 280 19 0 0 0 [[481, 759]] 1.0 2pz5 Homo sapiens TYR_FGFR2_HUMAN TYR 4.5e-104 353.3 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J97A P21802 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.55 14.123 BLAminus -139.14, -173.61 59.78, 71.54 -95.85, 23.3 290.64, 88.77 -67.56, -16.73 in-in in 7.316 Saltbr-in 3.004 HRD-in -83.97, -47.07 72.51, -7.44 in-in-out SNCiio in-out ActLoopNT-in 2.877 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.39, 21.13 APE9-dihe-in -97.79, 130.15 APE8-dihe-in -58.11, 126.83 APE8-rot-na 332.95 APE67-dihe-in -66.85, -7.34 -61.56, -42.87 APE12-dist-na 15.336 APE11-dist-na 10.692 APE10-dist-na 7.744 APE9-dist-in 4.882 C491A,K659E None None XRAY 2.548 0.202 0.257 A 324 282 15 0 0 0 [[481, 759]] 1.0 4j97 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J97B P21802 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.619 14.161 BLAminus -137.2, -170.97 56.98, 77.11 -102.2, 28.96 291.71, 89.32 -70.08, -17.2 in-in in 7.432 Saltbr-in 2.683 HRD-in -92.02, -43.47 71.93, -10.83 in-in-out SNCiio in-out ActLoopNT-in 2.882 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.22, 28.28 APE9-dihe-in -102.89, 130.04 APE8-dihe-in -52.94, 125.61 APE8-rot-na 331.88 APE67-dihe-in -68.38, -8.99 -59.09, -43.64 APE12-dist-na 15.333 APE11-dist-na 10.637 APE10-dist-na 7.778 APE9-dist-in 4.888 C491A,K659E None None XRAY 2.548 0.202 0.257 B 324 283 14 0 0 0 [[481, 759]] 1.0 4j97 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J97C P21802 467 764 821.0 ACP:801 ATPlike Inactive DFGin 6.645 13.946 BLAminus -135.48, -176.12 59.98, 78.76 -103.0, 29.61 294.18, 85.28 -73.23, -9.75 in-in in 7.37 Saltbr-in 2.772 HRD-in -84.13, -44.14 69.93, -6.04 in-in-out SNCiio in-out ActLoopNT-in 2.837 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.47, 19.13 APE9-dihe-in -91.95, 123.86 APE8-dihe-in -53.96, 120.55 APE8-rot-na 330.23 APE67-dihe-in -67.12, -15.11 -56.46, -44.57 APE12-dist-na 15.284 APE11-dist-na 10.828 APE10-dist-na 7.639 APE9-dist-in 4.85 C491A,K659E None None XRAY 2.548 0.202 0.257 C 324 283 15 0 0 0 [[481, 759]] 1.0 4j97 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J97D P21802 466 764 821.0 ACP:801 ATPlike Inactive DFGin 6.6 13.952 BLAminus -140.55, -174.15 59.58, 71.6 -94.76, 28.97 293.72, 82.5 -71.76, -12.96 in-in in 7.326 Saltbr-in 3.288 HRD-in -86.64, -45.82 71.0, -4.65 in-in-out SNCiio in-out ActLoopNT-in 2.976 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.43, 15.17 APE9-dihe-in -92.91, 126.7 APE8-dihe-in -55.77, 123.75 APE8-rot-na 332.18 APE67-dihe-in -67.8, -5.5 -58.98, -44.55 APE12-dist-na 15.175 APE11-dist-na 10.81 APE10-dist-na 7.653 APE9-dist-in 4.774 C491A,K659E None None XRAY 2.548 0.202 0.257 D 324 285 14 0 0 0 [[481, 759]] 1.0 4j97 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZPA P21802 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.348 14.188 BLAminus -137.17, -165.33 46.36, 75.76 -87.8, 26.94 288.76, 75.56 -66.87, -3.87 in-in in 7.412 Saltbr-in 2.646 HRD-in -73.32, -51.09 75.46, -8.12 in-in-out SNCiio in-out ActLoopNT-in 2.85 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.47, 19.17 APE9-dihe-in -100.03, 131.76 APE8-dihe-in -52.44, 119.43 APE8-rot-na 323.26 APE67-dihe-in -75.98, -2.12 -50.98, -36.8 APE12-dist-na 10.034 APE11-dist-na 10.845 APE10-dist-na 7.456 APE9-dist-in 4.835 C491A,K526E None None XRAY 2.4 0.214 0.251 A 324 280 19 0 0 0 [[481, 759]] 1.0 2pzp Homo sapiens TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZPB P21802 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.413 14.352 BLAminus -140.32, -168.12 49.24, 73.06 -87.89, 30.48 288.51, 77.76 -65.07, -14.98 in-in in 7.479 Saltbr-in 2.588 HRD-in -76.07, -43.76 66.74, -12.17 in-in-out SNCiio in-out ActLoopNT-in 2.931 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.0, 26.29 APE9-dihe-in -103.21, 127.34 APE8-dihe-in -50.89, 117.65 APE8-rot-na 324.07 APE67-dihe-in -70.61, -2.41 -52.07, -42.82 APE12-dist-na 10.141 APE11-dist-na 10.802 APE10-dist-na 7.451 APE9-dist-in 4.964 C491A,K526E None None XRAY 2.4 0.214 0.251 B 324 282 17 0 0 0 [[481, 759]] 1.0 2pzp Homo sapiens TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZRA P21802 468 765 821.0 ACP:803 ATPlike Inactive DFGin 6.528 14.087 BLAminus -124.48, -173.68 60.99, 80.27 -100.69, 20.88 290.45, 81.11 -57.12, -25.75 in-in in 7.418 Saltbr-in 2.648 HRD-in -69.22, -43.88 65.36, -10.35 in-in-out SNCiio in-out ActLoopNT-in 2.833 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -123.95, 17.65 APE9-dihe-in -96.03, 130.55 APE8-dihe-in -55.73, 111.71 APE8-rot-na 326.73 APE67-dihe-in -57.11, -22.38 -39.78, -52.21 APE12-dist-na 9.973 APE11-dist-na 10.692 APE10-dist-na 7.386 APE9-dist-in 4.734 C491A,K641R None None XRAY 3.0 0.201 0.268 A 324 280 18 0 0 0 [[481, 759]] 1.0 2pzr Homo sapiens TYR_FGFR2_HUMAN TYR 8.4e-104 352.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZRB P21802 467 766 821.0 ACP:803 ATPlike Inactive DFGin 6.446 14.135 BLAminus -124.12, -169.42 57.57, 72.92 -93.39, 13.68 295.44, 82.57 -53.73, -21.74 in-in in 7.634 Saltbr-in 2.706 HRD-in -69.55, -51.19 76.09, -22.69 in-in-out SNCiio in-out ActLoopNT-in 2.945 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.28, 13.02 APE9-dihe-in -94.85, 132.36 APE8-dihe-in -55.27, 118.14 APE8-rot-na 326.76 APE67-dihe-in -72.22, 2.52 -57.29, -38.32 APE12-dist-na 9.949 APE11-dist-na 10.979 APE10-dist-na 7.519 APE9-dist-in 5.016 C491A,K641R None None XRAY 3.0 0.201 0.268 B 324 282 18 0 0 0 [[481, 759]] 1.0 2pzr Homo sapiens TYR_FGFR2_HUMAN TYR 8.4e-104 352.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UHNA P21802 469 764 821.0 ACP:802 ATPlike Inactive DFGin 6.517 14.094 BLAminus -136.8, -167.33 56.16, 78.56 -101.45, 21.6 294.96, 102.9 -64.06, -30.14 in-in in 7.824 Saltbr-in 2.523 HRD-in -81.24, -42.19 65.24, 0.64 in-in-out SNCiio in-out ActLoopNT-in 2.963 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -130.72, 22.85 APE9-dihe-in -103.03, 139.99 APE8-dihe-in -59.98, 123.73 APE8-rot-na 335.04 APE67-dihe-in -66.52, -14.98 -63.65, -42.1 APE12-dist-na 14.855 APE11-dist-na 10.903 APE10-dist-na 7.587 APE9-dist-in 4.884 N549H,E565A None None XRAY 2.909 0.26 0.311 A 324 282 14 0 0 0 [[481, 759]] 1.0 5uhn Homo sapiens TYR_FGFR2_HUMAN TYR 3.3e-103 350.5 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UHNB P21802 469 764 821.0 ACP:802 ATPlike Inactive DFGin 6.513 14.023 BLAminus -136.33, -166.28 57.28, 77.94 -101.83, 20.57 295.09, 103.12 -64.81, -29.84 in-in in 7.663 Saltbr-in 2.464 HRD-in -80.51, -42.21 65.56, -0.07 in-in-out SNCiio in-out ActLoopNT-in 3.183 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -129.68, 22.67 APE9-dihe-in -103.05, 139.67 APE8-dihe-in -60.5, 125.01 APE8-rot-na 334.93 APE67-dihe-in -66.52, -14.36 -63.18, -41.76 APE12-dist-na 999.0 APE11-dist-na 10.814 APE10-dist-na 7.591 APE9-dist-in 4.817 N549H,E565A None None XRAY 2.909 0.26 0.311 B 324 269 27 0 0 11 [[481, 759]] 1.0 5uhn Homo sapiens TYR_FGFR2_HUMAN TYR 3.3e-103 350.5 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UGXA P21802 468 764 821.0 ACP:803 ATPlike Inactive DFGin 6.657 14.049 BLAminus -131.13, -166.11 46.79, 87.05 -100.0, 21.89 288.47, 85.57 -64.83, -24.6 in-in in 7.609 Saltbr-in 2.992 HRD-in -78.16, -51.21 73.9, -1.28 in-in-out SNCiio in-out ActLoopNT-in 2.867 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.33, 9.75 APE9-dihe-in -97.42, 138.88 APE8-dihe-in -59.74, 121.4 APE8-rot-na 334.26 APE67-dihe-in -70.7, -5.46 -65.5, -39.78 APE12-dist-na 15.029 APE11-dist-na 11.177 APE10-dist-na 7.458 APE9-dist-in 4.804 C491A,E565A None None XRAY 2.349 0.22 0.275 A 324 297 0 0 0 0 [[481, 759]] 1.0 5ugx Homo sapiens TYR_FGFR2_HUMAN TYR 4.5e-103 350.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UGXB P21802 468 764 821.0 ACP:803 ATPlike Inactive DFGin 6.711 13.923 BLAminus -132.31, -170.71 52.3, 81.71 -96.0, 22.25 292.25, 87.7 -65.69, -25.27 in-in in 7.393 Saltbr-in 3.154 HRD-in -75.61, -53.17 73.28, -1.77 in-in-out SNCiio in-out ActLoopNT-in 2.92 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.49, 16.52 APE9-dihe-in -100.17, 138.41 APE8-dihe-in -61.9, 122.99 APE8-rot-na 336.36 APE67-dihe-in -71.64, -5.56 -62.65, -38.67 APE12-dist-na 10.081 APE11-dist-na 10.766 APE10-dist-na 7.282 APE9-dist-in 4.828 C491A,E565A None None XRAY 2.349 0.22 0.275 B 324 282 15 0 0 10 [[481, 759]] 1.0 5ugx Homo sapiens TYR_FGFR2_HUMAN TYR 4.5e-103 350.0 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UI0B P21802 462 765 821.0 ACP:802 ATPlike Inactive DFGin 6.542 14.213 BLAminus -136.98, -171.82 50.02, 76.91 -91.39, 21.0 284.06, 84.3 -70.34, -15.26 in-in in 7.243 Saltbr-in 2.959 HRD-in -80.63, -49.98 74.74, -10.37 in-in-out SNCiio in-out ActLoopNT-in 2.937 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.5, 32.27 APE9-dihe-in -102.72, 128.27 APE8-dihe-in -51.42, 123.86 APE8-rot-na 328.96 APE67-dihe-in -69.39, -7.95 -60.08, -38.03 APE12-dist-na 14.784 APE11-dist-na 10.166 APE10-dist-na 7.606 APE9-dist-in 4.855 C491A,E565A None None XRAY 2.05 0.183 0.207 B 324 304 0 0 0 0 [[481, 759]] 1.0 5ui0 Homo sapiens TYR_FGFR2_HUMAN TYR 2.9e-103 350.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2Q0BA P21802 468 765 821.0 ACP:803 ATPlike Inactive DFGin 6.538 14.238 BLAminus -137.67, -164.26 54.31, 72.63 -95.24, 25.26 285.39, 75.18 -61.23, -29.58 in-in in 7.243 Saltbr-in 2.723 HRD-in -79.58, -49.69 74.6, -12.22 in-in-out SNCiio in-out ActLoopNT-in 2.975 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -123.18, 17.09 APE9-dihe-in -97.34, 129.87 APE8-dihe-in -55.33, 120.72 APE8-rot-na 329.23 APE67-dihe-in -73.97, -8.32 -57.44, -31.43 APE12-dist-na 9.977 APE11-dist-na 10.659 APE10-dist-na 7.369 APE9-dist-in 4.751 C491A,E565A None None XRAY 2.9 0.202 0.252 A 324 280 18 0 0 0 [[481, 759]] 1.0 2q0b Homo sapiens TYR_FGFR2_HUMAN TYR 2.1e-103 351.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2Q0BB P21802 468 766 821.0 ACP:803 ATPlike Inactive DFGin 6.564 14.08 BLAminus -133.38, -173.77 65.46, 65.65 -91.7, 18.1 296.71, 72.83 -55.14, -29.53 in-in in 7.517 Saltbr-in 2.736 HRD-in -79.58, -50.53 70.04, -4.81 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.91, 21.68 APE9-dihe-in -99.61, 129.39 APE8-dihe-in -57.39, 112.59 APE8-rot-na 331.0 APE67-dihe-in -63.49, -9.98 -54.36, -36.94 APE12-dist-na 10.247 APE11-dist-na 10.839 APE10-dist-na 7.492 APE9-dist-in 4.906 C491A,E565A None None XRAY 2.9 0.202 0.252 B 324 282 17 0 0 0 [[481, 759]] 1.0 2q0b Homo sapiens TYR_FGFR2_HUMAN TYR 2.1e-103 351.1 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PY3A P21802 468 766 821.0 ACP:805 ATPlike Inactive DFGin 6.395 14.125 BLAminus -132.09, -167.28 46.92, 77.9 -89.52, 28.18 287.97, 74.42 -64.92, -12.84 in-in in 7.278 Saltbr-in 2.643 HRD-in -69.15, -50.28 73.37, -7.92 in-in-out SNCiio in-out ActLoopNT-in 2.937 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.57, 22.43 APE9-dihe-in -99.04, 131.25 APE8-dihe-in -52.37, 122.48 APE8-rot-na 325.05 APE67-dihe-in -72.14, -6.33 -51.92, -40.9 APE12-dist-na 9.95 APE11-dist-na 10.671 APE10-dist-na 7.386 APE9-dist-in 4.744 C491A,E565G None None XRAY 2.3 0.217 0.252 A 324 282 17 0 0 0 [[481, 759]] 1.0 2py3 Homo sapiens TYR_FGFR2_HUMAN TYR 2.7e-103 350.7 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PY3B P21802 468 766 821.0 ACP:805 ATPlike Inactive DFGin 6.515 14.301 BLAminus -135.62, -170.09 51.9, 73.7 -89.2, 28.31 287.78, 75.56 -66.05, -13.03 in-in in 7.425 Saltbr-in 2.704 HRD-in -75.46, -47.46 71.33, -10.27 in-in-out SNCiio in-out ActLoopNT-in 2.857 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.61, 23.33 APE9-dihe-in -100.25, 127.63 APE8-dihe-in -52.55, 116.2 APE8-rot-na 325.69 APE67-dihe-in -68.53, -13.02 -47.88, -42.42 APE12-dist-na 10.066 APE11-dist-na 10.788 APE10-dist-na 7.419 APE9-dist-in 4.931 C491A,E565G None None XRAY 2.3 0.217 0.252 B 324 284 15 0 0 0 [[481, 759]] 1.0 2py3 Homo sapiens TYR_FGFR2_HUMAN TYR 2.7e-103 350.7 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5EG3A P21802 466 774 821.0 ACP:60801 ATPlike Active DFGin 6.034 13.825 BLAminus -138.71, -166.61 47.53, 87.44 -100.17, 28.73 285.85, 82.29 -77.8, -14.99 in-in in 8.045 Saltbr-in 2.941 HRD-in -83.82, -45.21 62.18, 9.75 in-in-in SNCiii in-in ActLoopNT-in 2.991 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.56, 121.06 APE9-dihe-in -128.9, 119.34 APE8-dihe-in -79.6, 67.11 APE8-rot-na 30.51 APE67-dihe-in -77.81, 0.08 -48.0, -39.27 APE12-dist-na 13.558 APE11-dist-na 10.078 APE10-dist-na 8.259 APE9-dist-in 7.021 Y466F,C491A,E565A,Y586L,Y588P,Y656F,Y657F,K659E PTR769 PTR769 XRAY 2.606 0.191 0.237 A 334 302 7 0 0 0 [[481, 759]] 1.0 5eg3 Homo sapiens TYR_FGFR2_HUMAN TYR 2.3e-101 344.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 6V6QA P21802 466 765 821.0 ACP:901 ATPlike Inactive DFGin 6.894 13.908 BLAminus -137.26, -178.98 59.51, 71.9 -86.77, 13.5 292.04, 83.56 -59.04, -31.29 in-in in 7.246 Saltbr-in 3.289 HRD-in -72.64, -45.97 77.04, -16.81 in-in-out SNCiio in-out ActLoopNT-in 2.928 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.45, 33.95 APE9-dihe-in -111.95, 129.79 APE8-dihe-in -53.65, 121.81 APE8-rot-na 327.05 APE67-dihe-in -70.56, -11.31 -58.83, -38.12 APE12-dist-na 14.264 APE11-dist-na 10.49 APE10-dist-na 7.77 APE9-dist-in 5.206 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 A 411 286 14 0 0 0 [[481, 759]] 1.0 6v6q Homo sapiens TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 6V6QB P21802 467 766 821.0 ACP:901 ATPlike Inactive DFGin 6.809 14.125 BLAminus -136.61, -177.61 60.52, 69.31 -88.63, 15.47 290.7, 96.84 -63.12, -28.34 in-in in 7.343 Saltbr-in 3.295 HRD-in -73.07, -46.4 74.87, -14.44 in-in-out SNCiio in-out ActLoopNT-in 2.92 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.84, 37.71 APE9-dihe-in -109.58, 130.31 APE8-dihe-in -50.87, 122.1 APE8-rot-na 324.14 APE67-dihe-in -69.97, -12.27 -61.49, -37.1 APE12-dist-na 14.135 APE11-dist-na 10.587 APE10-dist-na 8.065 APE9-dist-in 5.152 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 B 411 291 9 0 0 0 [[481, 759]] 1.0 6v6q Homo sapiens TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 6V6QD P21802 467 765 821.0 ACP:901 ATPlike Inactive DFGin 6.936 13.989 BLAminus -136.56, -179.05 59.21, 72.83 -88.1, 16.16 292.51, 97.85 -58.15, -33.51 in-in in 7.38 Saltbr-in 3.334 HRD-in -71.81, -47.08 75.08, -13.84 in-in-out SNCiio in-out ActLoopNT-in 2.942 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.25, 35.34 APE9-dihe-in -111.85, 128.58 APE8-dihe-in -53.13, 121.4 APE8-rot-na 327.69 APE67-dihe-in -69.26, -12.5 -60.26, -36.04 APE12-dist-na 999.0 APE11-dist-na 10.14 APE10-dist-na 7.433 APE9-dist-in 5.112 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 D 411 276 23 0 0 9 [[481, 759]] 1.0 6v6q Homo sapiens TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 6V6QC P21802 467 766 821.0 ACP:901 ATPlike Inactive DFGin 6.766 13.643 BLBminus -136.89, -177.89 59.28, 74.24 -85.91, -161.66 300.29, 95.93 81.23, -12.62 in-in in 7.463 Saltbr-in 3.314 HRD-in -72.01, -47.4 74.74, -13.46 in-in-out SNCiio in-out ActLoopNT-in 2.941 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.47, 28.67 APE9-dihe-in -111.04, 128.94 APE8-dihe-in -52.92, 121.96 APE8-rot-na 327.46 APE67-dihe-in -69.24, -12.82 -58.84, -37.31 APE12-dist-na 999.0 APE11-dist-na 10.498 APE10-dist-na 7.431 APE9-dist-in 5.088 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 C 411 279 21 0 0 11 [[481, 759]] 1.0 6v6q Homo sapiens TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR3 FGFR3_HUMAN 4K33A P22607 459 755 806.0 ACP:801 ATPlike Active DFGin 6.252 13.787 BLAminus -133.88, -173.58 58.49, 82.81 -96.43, 27.55 291.81, 80.95 -59.32, -31.32 in-in in 8.211 Saltbr-in 2.895 HRD-in -87.09, -47.34 67.06, 1.63 in-in-in SNCiii in-in ActLoopNT-in 2.99 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.89, 133.11 APE9-dihe-in -125.43, 130.21 APE8-dihe-in -78.76, 72.58 APE8-rot-na 29.71 APE67-dihe-in -71.45, -4.47 -50.14, -48.75 APE12-dist-na 13.31 APE11-dist-na 9.602 APE10-dist-na 8.305 APE9-dist-in 6.873 C482A,C582S,K650E None None XRAY 2.341 0.181 0.228 A 325 293 4 0 0 0 [[472, 750]] 1.0 4k33 Homo sapiens TYR_FGFR3_HUMAN TYR 2.3e-104 354.2 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 6PNXA P22607 456 757 806.0 ACP:801 ATPlike Inactive DFGin 5.183 13.257 BLAplus -117.43, 165.96 59.53, 36.21 -90.35, -22.61 56.49, 88.29 -100.71, 20.75 in-out in 7.758 Saltbr-out 3.892 HRD-in -72.74, -43.96 72.66, -12.59 out-out-out SNCooo out-out ActLoopNT-out 8.611 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 61.32, -168.18 APE9-dihe-in -95.45, 138.6 APE8-dihe-in -83.08, 62.92 APE8-rot-na 32.84 APE67-dihe-in -77.59, -4.01 -63.19, -31.79 APE12-dist-na 17.76 APE11-dist-na 14.387 APE10-dist-na 16.475 APE9-dist-in 7.98 C482A,C582S,R669E None None XRAY 2.199 0.195 0.23 A 324 291 11 0 0 0 [[472, 750]] 1.0 6pnx Homo sapiens TYR_FGFR3_HUMAN TYR 2.5e-104 354.1 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 6PNXB P22607 455 756 806.0 ACP:801 ATPlike Inactive DFGin 5.102 12.88 BLAplus -116.22, 163.18 57.59, 45.48 -96.33, -11.84 56.51, 88.18 -107.89, 22.55 in-in in 7.372 Saltbr-in 2.381 HRD-in -94.02, -38.66 69.29, -17.12 in-out-out SNCioo out-out ActLoopNT-out 4.149 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 54.33, 74.29 APE9-dihe-in -157.39, 146.53 APE8-dihe-in -79.85, 92.16 APE8-rot-na 29.38 APE67-dihe-in -64.97, -14.94 -62.55, -40.44 APE12-dist-na 17.529 APE11-dist-na 16.958 APE10-dist-na 14.632 APE9-dist-in 7.491 C482A,C582S,R669E None None XRAY 2.199 0.195 0.23 B 324 294 8 0 0 0 [[472, 750]] 1.0 6pnx Homo sapiens TYR_FGFR3_HUMAN TYR 2.5e-104 354.1 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR IGF1R IGF1R_HUMAN 1K3AA P08069 988 1286 1367.0 ACP:60300 ATPlike Inactive DFGin 6.326 14.213 ABAminus -128.41, -4.91 -126.86, 131.72 -125.9, 30.62 307.04, 99.18 -55.79, -30.44 in-out in 9.005 Saltbr-out 4.763 HRD-in -68.21, -48.33 72.95, -10.46 out-in-in SNCoii in-in ActLoopNT-in 2.922 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.81, 106.37 APE9-dihe-in -118.2, 152.14 APE8-dihe-in -73.75, 68.45 APE8-rot-na 35.41 APE67-dihe-in -73.37, -1.85 -44.97, -44.15 APE12-dist-na 15.179 APE11-dist-na 11.105 APE10-dist-na 10.844 APE9-dist-in 7.129 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.1 0.212 0.251 A 299 291 8 0 0 0 [[999, 1268]] 1.0 1k3a Homo sapiens TYR_IGF1R_HUMAN TYR 3.1e-95 324.3 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR INSR INSR_HUMAN 4XLVA P06213 1001 1310 1382.0 ACP:61301 ATPlike Active DFGin 6.357 13.404 BLAminus -129.47, -169.61 59.33, 81.3 -99.86, 10.75 301.2, 100.62 -50.37, -35.15 in-in in 8.175 Saltbr-in 2.441 HRD-in -74.09, -41.95 72.32, -7.69 in-in-in SNCiii in-in ActLoopNT-in 3.029 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -31.8, 98.01 APE9-dihe-in -128.43, 131.43 APE8-dihe-in -62.62, 111.75 APE8-rot-na 18.22 APE67-dihe-in -71.49, -19.39 -64.21, -23.54 APE12-dist-na 14.741 APE11-dist-na 10.551 APE10-dist-na 11.027 APE9-dist-in 6.615 Y992F,C1008S PTR999,PTR1185,PTR1189,PTR1190 PTR999,PTR1185,PTR1189,PTR1190 XRAY 2.3 0.207 0.266 A 328 310 0 0 0 0 [[1023, 1292]] 1.0 4xlv Homo sapiens TYR_INSR_HUMAN TYR 1.7e-96 328.5 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR INSR INSR_HUMAN 1I44A P06213 1013 1310 1382.0 ACP:60300 ATPlike Inactive DFGin 6.641 13.72 None -58.16, -57.88 -145.23, -170.38 -78.54, 6.88 58.45, 76.71 123.48, 176.59 in-out in 9.122 Saltbr-out 5.895 HRD-in -61.91, -52.97 77.04, -9.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -75.06 APE8-dihe-out -68.29, 48.19 APE8-rot-na 34.45 APE67-dihe-in -67.23, -7.11 -39.74, -51.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.683 C1008S,Y1011F,D1188A None None XRAY 2.4 0.21 0.268 A 306 282 16 0 0 16 [[1023, 1292]] 1.0 1i44 Homo sapiens TYR_INSR_HUMAN TYR 3.4e-96 327.5 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR TNK2 ACK1_HUMAN 1U54A Q07912 115 390 1038.0 ACP:101 ATPlike Inactive DFGin 6.381 13.426 ABAminus -129.39, -12.11 -146.47, 102.96 -102.84, 23.33 304.65, 105.91 -57.05, -37.37 in-in in 7.864 Saltbr-in 2.624 HRD-in -77.15, -49.8 83.51, -10.59 in-in-none SNCiin in-none ActLoopNT-in 2.835 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.54 APE8-dihe-in -75.47, 123.76 APE8-rot-na 349.96 APE67-dihe-in -43.9, -19.78 -62.08, -52.54 APE12-dist-na 11.808 APE11-dist-na 8.141 APE10-dist-na 999.0 APE9-dist-in 6.063 None PTR284 PTR284 XRAY 2.8 0.226 0.322 A 291 263 13 0 0 1 [[126, 387]] 1.0 1u54 Homo sapiens TYR_TNK2_HUMAN TYR 9e-86 293.3 1 259 259 269 270 271 273 275 158 177 181 249 251 250 252 312 300 295 294 293 292 291 290 289 206 Activated CDC42 kinase 1
TYR TNK2 ACK1_HUMAN 1U54B Q07912 117 388 1038.0 ACP:400 ATPlike Active DFGin 6.615 13.378 BLAminus -120.4, -155.16 27.84, 85.75 -104.36, 38.7 310.01, 93.15 -67.71, -28.73 in-in in 7.966 Saltbr-in 3.021 HRD-in -109.84, -42.56 64.6, 13.11 in-in-in SNCiii in-in ActLoopNT-in 3.014 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -150.8, 133.1 APE9-dihe-in -126.86, 129.0 APE8-dihe-in -43.1, 130.27 APE8-rot-na 329.12 APE67-dihe-in -70.13, -6.6 -62.78, -39.45 APE12-dist-na 12.662 APE11-dist-na 7.646 APE10-dist-na 11.0 APE9-dist-in 5.878 None None None XRAY 2.8 0.226 0.322 B 291 261 11 0 0 0 [[126, 387]] 1.0 1u54 Homo sapiens TYR_TNK2_HUMAN TYR 9e-86 293.3 1 259 259 269 270 271 273 275 158 177 181 249 251 250 252 312 300 295 294 293 292 291 290 289 206 Activated CDC42 kinase 1
AGC PRKACA KAPCA_MOUSE 4IACA P05132 16 351 351.0 ACP:60403 ATPlike Active DFGin 5.755 14.312 BLAminus -125.73, -177.16 59.8, 78.08 -94.31, 23.06 273.35, 54.81 -46.36, -37.92 in-in in 8.885 Saltbr-in 2.721 HRD-in -73.57, -53.97 72.67, 5.23 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.57, 156.93 APE9-dihe-na 137.19, -153.99 APE8-dihe-in -123.03, 128.21 APE8-rot-in 300.87 APE67-dihe-in -59.06, -23.99 -31.47, -61.7 APE12-dist-in 8.157 APE11-dist-in 11.515 APE10-dist-in 5.985 APE9-dist-in 3.502 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.15 0.181 0.212 A 356 336 0 0 0 0 [[44, 298]] 1.0 4iac Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CMGC MAPK14 MK14_MOUSE 8VMMA P47811 5 354 360.0 A1ACP:602 Type1 Inactive DFGin 10.984 13.159 None -98.06, 143.62 -67.61, -42.07 -138.88, 122.62 295.3, 103.53 -85.47, 178.15 in-in in 9.427 Saltbr-in 2.538 HRD-in -74.94, -56.81 76.36, -7.57 in-out-out SNCioo out-out ActLoopNT-out 21.111 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 103.41 APE9-dihe-na -75.99, -11.35 APE8-dihe-out 77.98, -40.95 APE8-rot-in 311.13 APE67-dihe-in -68.54, -15.53 -53.31, -26.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.503 APE9-dist-out 11.825 None None None XRAY 2.4 0.207 0.263 A 367 341 9 0 0 9 [[24, 308]] 1.0 8vmm Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
OTHER PKNB PKNB_MYCTU 1O6YA P9WI81 3 278 626.0 ACP:1279 ATPlike None DFGin 5.309 14.78 BLAminus -139.04, -177.54 67.82, 83.57 -97.92, 24.81 285.65, 79.79 -51.43, -35.15 in-in in 8.242 Saltbr-in 2.792 HRD-in -70.46, -52.6 71.79, -5.94 in-in-none SNCiin in-none ActLoopNT-in 2.752 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -69.25, -16.6 999.0, -48.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.193 0.23 A 299 260 16 0 0 16 [[11, 273]] 1.0 1o6y Mycobacterium tuberculosis OTHER_PKNB_MYCTU CAMK 6.4e-46 162.7 1 248 248 155 156 157 159 161 40 59 63 135 137 136 138 198 186 181 180 179 178 177 176 175 93 Serine/threonine-protein kinase PknB
OTHER PKNB PKNB_MYCTU 6I2PA P9WI81 1 278 626.0 ACP:301 ATPlike Inactive None 11.318 16.972 None -125.13, 175.99 66.11, 55.5 -97.33, 137.94 289.87, 87.88 -101.43, 158.5 in-out in 8.383 Saltbr-out 4.155 HRD-in -62.97, -54.02 77.2, -15.49 out-out-out SNCooo out-out ActLoopNT-out 7.951 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iooo APE10-dihe-na -69.22, 139.86 APE9-dihe-na 130.91, -153.5 APE8-dihe-out -75.55, -19.27 APE8-rot-out 56.79 APE67-dihe-out -64.87, -19.1 65.77, 0.83 APE12-dist-in 13.466 APE11-dist-out 18.442 APE10-dist-out 19.024 APE9-dist-out 10.611 L33E TPO171,TPO173 TPO171,TPO173 XRAY 2.37 0.221 0.234 A 280 272 6 0 0 6 [[11, 273]] 1.0 6i2p Mycobacterium tuberculosis OTHER_PKNB_MYCTU CAMK 1.7e-46 164.7 1 248 248 155 156 157 159 161 40 59 63 135 137 136 138 198 186 181 180 179 178 177 176 175 93 Serine/threonine-protein kinase PknB
OTHER PKNB PKNB_MYCTU 6I2PB P9WI81 2 277 626.0 ACP:301 ATPlike Inactive None 11.747 17.094 None -128.89, 178.08 68.33, 50.19 -91.53, 128.09 288.96, 86.92 -86.75, 157.61 in-out in 8.394 Saltbr-out 4.197 HRD-in -57.76, -51.63 76.05, -15.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_onnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -18.66 APE8-rot-none 999.0 APE67-dihe-out -74.3, -17.9 61.65, 10.67 APE12-dist-out 17.404 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 L33E TPO171,TPO173 TPO171,TPO173 XRAY 2.37 0.221 0.234 B 280 266 10 0 0 10 [[11, 273]] 1.0 6i2p Mycobacterium tuberculosis OTHER_PKNB_MYCTU CAMK 1.7e-46 164.7 1 248 248 155 156 157 159 161 40 59 63 135 137 136 138 198 186 181 180 179 178 177 176 175 93 Serine/threonine-protein kinase PknB
OTHER None A0ACD6BAW3_SERSF 5X1SA A0ACD6BAW3 11 296 302.0 ACP:401 ATPlike Inactive DFGin 5.832 14.692 ABAminus -96.4, -24.72 -170.23, 137.88 -105.86, 1.75 300.3, 151.0 67.71, 19.62 in-out in 9.734 Saltbr-out 8.331 HRD-in -80.12, -62.12 76.3, 5.26 out-out-out SNCooo out-out ActLoopNT-out 13.65 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -89.47, -71.6 APE9-dihe-na -93.84, 155.24 APE8-dihe-in -97.91, 113.31 APE8-rot-na 292.47 APE67-dihe-inflip 92.15, -27.36 -59.62, 132.23 APE12-dist-out 15.313 APE11-dist-in 10.425 APE10-dist-out 9.63 APE9-dist-out 6.248 None None None XRAY 1.45 0.196 0.217 A 302 281 5 0 0 0 [[23, 295]] 1.0 5x1s Serratia sp. OTHER_None_SERSF NEK 2.2e-22 86.3 1 248 248 182 183 184 186 188 52 89 93 162 164 163 165 225 210 205 204 203 202 201 200 199 119 PpkA N terminal

Ligand: ACP

Total number of chains: 9
Active chains: 1
Total number of genes: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 55.6% 4F0FA
None None 2 22.2% 6I2PA
DFGin ABAminus 1 11.1% 5X1SA
DFGin None 1 11.1% 8VMMA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL ROCO4 ROCO4_DICDI 4F0FA Q6XHB2 1019 1292 1726.0 ACP:61301 ATPlike Inactive DFGin 6.95 15.963 BLAminus -130.66, 172.28 62.24, 70.89 -92.37, 29.04 286.11, 76.52 -66.1, -24.87 in-in in 8.455 Saltbr-in 2.573 HRD-in -73.46, -44.25 65.79, 5.9 in-in-out SNCiio in-out ActLoopNT-in 2.599 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -114.23, 137.57 APE9-dihe-na -90.18, -37.76 APE8-dihe-in -70.88, 120.21 APE8-rot-na 222.83 APE67-dihe-in -78.4, -5.47 -115.68, -26.3 APE12-dist-in 10.18 APE11-dist-in 12.511 APE10-dist-out 9.222 APE9-dist-out 8.3 None None None XRAY 1.8 0.198 0.245 A 287 274 0 0 0 0 [[1026, 1291]] 1.0 4f0f Dictyostelium discoideum TKL_ROCO4_DICDI TKL 3.2e-59 206.6 2 266 265 1176 1177 1178 1180 1182 1055 1078 1082 1151 1153 1152 1154 1215 1201 1196 1195 1194 1193 1192 1191 1190 1106 Probable serine/threonine-protein kinase roco4
TKL ROCO4 ROCO4_DICDI 4F1OA Q6XHB2 1019 1292 1726.0 ACP:61301 ATPlike Inactive DFGin 7.11 15.543 BLAminus -139.35, 175.97 61.59, 71.39 -91.48, 35.72 286.47, 73.49 -70.25, -38.98 in-in in 8.086 Saltbr-in 2.782 HRD-in -70.19, -38.92 67.65, -6.5 in-in-out SNCiio in-out ActLoopNT-in 2.702 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -99.87, 151.06 APE9-dihe-na -83.99, -54.56 APE8-dihe-in -77.41, 78.95 APE8-rot-na 217.99 APE67-dihe-in -67.17, -15.56 -63.92, -29.08 APE12-dist-in 10.348 APE11-dist-in 12.806 APE10-dist-out 9.072 APE9-dist-out 8.14 None None None XRAY 2.3 0.252 0.296 A 287 274 0 0 0 0 [[1026, 1291]] 1.0 4f1o Dictyostelium discoideum TKL_ROCO4_DICDI TKL 1.1e-58 204.8 2 266 265 1176 1177 1178 1180 1182 1055 1078 1082 1151 1153 1152 1154 1215 1201 1196 1195 1194 1193 1192 1191 1190 1106 Probable serine/threonine-protein kinase roco4
TKL ROCO4 ROCO4_DICDI 4F1MA Q6XHB2 1019 1292 1726.0 ACP:61301,BTB:61302 ATPlike,Allosteric Inactive DFGin 6.734 15.31 BLAminus -135.93, 167.45 61.64, 76.62 -97.37, 30.41 286.17, 86.15 -92.2, 166.07 in-in in 8.148 Saltbr-in 2.843 HRD-in -65.4, -53.97 73.14, 3.41 in-in-out SNCiio in-out ActLoopNT-in 2.704 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -114.68, 138.58 APE9-dihe-na -71.39, -65.99 APE8-dihe-in -65.85, 83.01 APE8-rot-na 289.29 APE67-dihe-in -75.86, -13.39 -67.18, -17.16 APE12-dist-in 10.016 APE11-dist-in 11.777 APE10-dist-out 8.678 APE9-dist-out 7.791 G1179S None None XRAY 2.04 0.263 0.294 A 287 274 0 0 0 0 [[1026, 1291]] 1.0 4f1m Dictyostelium discoideum TKL_ROCO4_DICDI TKL 3.2e-58 203.3 2 266 265 1176 1177 1178 1180 1182 1055 1078 1082 1151 1153 1152 1154 1215 1201 1196 1195 1194 1193 1192 1191 1190 1106 Probable serine/threonine-protein kinase roco4
AGC PRKACA KAPCA_MOUSE 4IACA P05132 16 351 351.0 ACP:60403 ATPlike Active DFGin 5.755 14.312 BLAminus -125.73, -177.16 59.8, 78.08 -94.31, 23.06 273.35, 54.81 -46.36, -37.92 in-in in 8.885 Saltbr-in 2.721 HRD-in -73.57, -53.97 72.67, 5.23 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.57, 156.93 APE9-dihe-na 137.19, -153.99 APE8-dihe-in -123.03, 128.21 APE8-rot-in 300.87 APE67-dihe-in -59.06, -23.99 -31.47, -61.7 APE12-dist-in 8.157 APE11-dist-in 11.515 APE10-dist-in 5.985 APE9-dist-in 3.502 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.15 0.181 0.212 A 356 336 0 0 0 0 [[44, 298]] 1.0 4iac Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CMGC MAPK14 MK14_MOUSE 8VMMA P47811 5 354 360.0 A1ACP:602 Type1 Inactive DFGin 10.984 13.159 None -98.06, 143.62 -67.61, -42.07 -138.88, 122.62 295.3, 103.53 -85.47, 178.15 in-in in 9.427 Saltbr-in 2.538 HRD-in -74.94, -56.81 76.36, -7.57 in-out-out SNCioo out-out ActLoopNT-out 21.111 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 103.41 APE9-dihe-na -75.99, -11.35 APE8-dihe-out 77.98, -40.95 APE8-rot-in 311.13 APE67-dihe-in -68.54, -15.53 -53.31, -26.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.503 APE9-dist-out 11.825 None None None XRAY 2.4 0.207 0.263 A 367 341 9 0 0 9 [[24, 308]] 1.0 8vmm Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
OTHER PKNB PKNB_MYCTU 1O6YA P9WI81 3 278 626.0 ACP:1279 ATPlike None DFGin 5.309 14.78 BLAminus -139.04, -177.54 67.82, 83.57 -97.92, 24.81 285.65, 79.79 -51.43, -35.15 in-in in 8.242 Saltbr-in 2.792 HRD-in -70.46, -52.6 71.79, -5.94 in-in-none SNCiin in-none ActLoopNT-in 2.752 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -69.25, -16.6 999.0, -48.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.193 0.23 A 299 260 16 0 0 16 [[11, 273]] 1.0 1o6y Mycobacterium tuberculosis OTHER_PKNB_MYCTU CAMK 6.4e-46 162.7 1 248 248 155 156 157 159 161 40 59 63 135 137 136 138 198 186 181 180 179 178 177 176 175 93 Serine/threonine-protein kinase PknB
OTHER PKNB PKNB_MYCTU 6I2PA P9WI81 1 278 626.0 ACP:301 ATPlike Inactive None 11.318 16.972 None -125.13, 175.99 66.11, 55.5 -97.33, 137.94 289.87, 87.88 -101.43, 158.5 in-out in 8.383 Saltbr-out 4.155 HRD-in -62.97, -54.02 77.2, -15.49 out-out-out SNCooo out-out ActLoopNT-out 7.951 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iooo APE10-dihe-na -69.22, 139.86 APE9-dihe-na 130.91, -153.5 APE8-dihe-out -75.55, -19.27 APE8-rot-out 56.79 APE67-dihe-out -64.87, -19.1 65.77, 0.83 APE12-dist-in 13.466 APE11-dist-out 18.442 APE10-dist-out 19.024 APE9-dist-out 10.611 L33E TPO171,TPO173 TPO171,TPO173 XRAY 2.37 0.221 0.234 A 280 272 6 0 0 6 [[11, 273]] 1.0 6i2p Mycobacterium tuberculosis OTHER_PKNB_MYCTU CAMK 1.7e-46 164.7 1 248 248 155 156 157 159 161 40 59 63 135 137 136 138 198 186 181 180 179 178 177 176 175 93 Serine/threonine-protein kinase PknB
OTHER PKNB PKNB_MYCTU 6I2PB P9WI81 2 277 626.0 ACP:301 ATPlike Inactive None 11.747 17.094 None -128.89, 178.08 68.33, 50.19 -91.53, 128.09 288.96, 86.92 -86.75, 157.61 in-out in 8.394 Saltbr-out 4.197 HRD-in -57.76, -51.63 76.05, -15.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_onnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -18.66 APE8-rot-none 999.0 APE67-dihe-out -74.3, -17.9 61.65, 10.67 APE12-dist-out 17.404 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 L33E TPO171,TPO173 TPO171,TPO173 XRAY 2.37 0.221 0.234 B 280 266 10 0 0 10 [[11, 273]] 1.0 6i2p Mycobacterium tuberculosis OTHER_PKNB_MYCTU CAMK 1.7e-46 164.7 1 248 248 155 156 157 159 161 40 59 63 135 137 136 138 198 186 181 180 179 178 177 176 175 93 Serine/threonine-protein kinase PknB
OTHER None A0ACD6BAW3_SERSF 5X1SA A0ACD6BAW3 11 296 302.0 ACP:401 ATPlike Inactive DFGin 5.832 14.692 ABAminus -96.4, -24.72 -170.23, 137.88 -105.86, 1.75 300.3, 151.0 67.71, 19.62 in-out in 9.734 Saltbr-out 8.331 HRD-in -80.12, -62.12 76.3, 5.26 out-out-out SNCooo out-out ActLoopNT-out 13.65 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -89.47, -71.6 APE9-dihe-na -93.84, 155.24 APE8-dihe-in -97.91, 113.31 APE8-rot-na 292.47 APE67-dihe-inflip 92.15, -27.36 -59.62, 132.23 APE12-dist-out 15.313 APE11-dist-in 10.425 APE10-dist-out 9.63 APE9-dist-out 6.248 None None None XRAY 1.45 0.196 0.217 A 302 281 5 0 0 0 [[23, 295]] 1.0 5x1s Serratia sp. OTHER_None_SERSF NEK 2.2e-22 86.3 1 248 248 182 183 184 186 188 52 89 93 162 164 163 165 225 210 205 204 203 202 201 200 199 119 PpkA N terminal