Ligand: ACP

Total number of chains: 91
Active chains: 10
Total number of genes: 19
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 63 69.2% 5UI0B
DFGin BLBplus 10 11.0% 4ANBA
DFGin ABAminus 6 6.6% 6EQ9A
DFGin BLBminus 5 5.5% 7KJCA
DFGin BLAplus 2 2.2% 6PNXB
DFGin None 2 2.2% 4C3PA
DFGinter None 2 2.2% 4C3RA
None None 1 1.1% 6C83A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC PRKCI KPCI_HUMAN 5LI9A P41743 248 589 596.0 ACP:60601 ATPlike Active DFGin 5.6347 12.6326 BLAminus -139.17, 172.4 72.31, 78.11 -98.86, 1.23 304.03, 143.26 -64.9, -22.84 in-in in 8.3605 Saltbr-in 2.6142 HRD-in -73.79, -55.22 70.11, -1.11 in-in-in SNCiii in-in ActLoopNT-in 2.8096 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.64, 169.55 APE9-dihe-na 127.72, -178.47 APE8-dihe-in -93.25, 127.56 APE8-rot-in 298.81 APE67-dihe-in -60.64, -20.02 -47.28, -45.36 APE12-dist-in 8.8117 APE11-dist-in 11.9487 APE10-dist-in 6.4318 APE9-dist-in 3.8358 None TPO412,TPO564 TPO412,TPO564 XRAY 1.79 0.19 0.231 A 350.0 330.0 12 28 28 0 [[254, 522]] 1.0 5li9 AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC RPS6KA1-1 KS6A1_HUMAN 2Z7QA Q15418 56 340 735.0 ACP:500 ATPlike Inactive DFGin 8.0284 12.3687 BLBplus -135.49, 158.95 63.12, 60.24 -125.42, -165.59 47.01, 74.46 107.04, -8.15 none-none none 999.0 Saltbr-none 999.0 HRD-out -82.53, 70.19 -54.28, -43.87 none-out-out SNCnoo out-out ActLoopNT-out 7.0527 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -165.36 APE8-dihe-in -67.18, 106.47 APE8-rot-in 305.06 APE67-dihe-in -59.78, -23.27 -56.13, -39.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.7913 None None None XRAY 2.0 0.264 0.283 A 321.0 255.0 30 28 16 12 [[62, 321], [418, 675]] 2.0 2z7q AGC_RPS6KA1-1_HUMAN AGC 1.5e-95 325.1 1.0 260.0 260.0 204 205 206 208 210 94 112 116 184 186 185 187.0 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
CAMK AURKA AURKA_HUMAN 4C3PD O14965 125 390 403.0 ACP:1391 ATPlike Inactive DFGin 5.0797 15.0907 ABAminus -119.78, -23.96 -110.92, 146.31 -144.29, 22.56 288.75, 97.88 -63.46, -34.21 out-out out 11.1639 Saltbr-out 5.9729 HRD-out -75.78, -41.12 71.55, -101.13 out-in-out SNCoio in-out ActLoopNT-in 3.1113 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -140.51, -146.18 APE9-dihe-na 83.68, 6.59 APE8-dihe-out -140.3, 13.24 APE8-rot-out 207.12 APE67-dihe-in -44.87, -30.51 -70.19, -27.98 APE12-dist-none 999.0 APE11-dist-out 20.8704 APE10-dist-out 24.1292 APE9-dist-out 28.582 None None None XRAY 2.69 0.205 0.289 D 282.0 260.0 6 26 20 6 [[133, 383]] 1.0 4c3p CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5G15A O14965 126 390 403.0 ACP:1391 ATPlike Inactive DFGin 5.983 16.3862 BLAminus -138.69, -169.03 59.87, 67.73 -86.51, 18.94 284.94, 72.05 -48.14, -38.59 out-out out 10.2958 Saltbr-out 5.1725 HRD-in -73.28, -52.04 69.95, 14.4 out-in-in SNCoii in-in ActLoopNT-in 2.9265 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.64, 165.4 APE9-dihe-na 125.58, -148.7 APE8-dihe-in -133.46, 135.34 APE8-rot-in 292.83 APE67-dihe-in -71.67, -13.58 -36.11, -59.51 APE12-dist-in 10.3189 APE11-dist-in 11.1833 APE10-dist-in 5.6098 APE9-dist-in 3.4626 None None None XRAY 2.06 0.229 0.274 A 282.0 265.0 0 26 26 0 [[133, 383]] 1.0 5g15 CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6CPFA O14965 128 392 403.0 ACP:501 ATPlike Inactive DFGin 5.8515 16.0756 BLAminus -125.44, -173.01 51.86, 75.65 -92.36, 20.23 261.59, 77.98 -63.75, -18.06 out-none out 11.2478 Saltbr-none 999.0 HRD-in -104.84, -51.34 76.83, -36.49 none-in-out SNCnio in-out ActLoopNT-in 3.2019 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -168.9 APE8-dihe-in -78.28, 136.09 APE8-rot-out 59.9 APE67-dihe-in -54.01, -29.69 -75.21, 5.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7077 None None None XRAY 2.3 0.222 0.259 A 285.0 259.0 6 26 20 6 [[133, 383]] 1.0 6cpf CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4C3PA O14965 125 388 403.0 ACP:1389 ATPlike Inactive DFGin 5.1209 15.3112 None -143.16, 44.14 -117.33, -72.7 63.16, 22.36 309.54, 103.5 -71.05, -27.42 out-out out 10.7129 Saltbr-out 4.9547 HRD-out -79.39, 150.41 -121.39, -68.05 out-in-out SNCoio in-out ActLoopNT-in 2.8189 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -49.34, 122.38 APE9-dihe-na 116.03, -35.9 APE8-dihe-out -100.65, -0.54 APE8-rot-out 177.69 APE67-dihe-in -57.5, -32.82 -45.19, -41.29 APE12-dist-out 20.9276 APE11-dist-out 21.1759 APE10-dist-out 26.1561 APE9-dist-out 28.5914 None None None XRAY 2.69 0.205 0.289 A 282.0 264.0 0 26 26 0 [[133, 383]] 1.0 4c3p CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4C3RA O14965 127 388 403.0 ACP:1389 ATPlike Inactive DFGinter 6.0871 8.639 None -114.31, -7.36 -87.64, 130.6 -72.8, -47.16 285.43, 29.08 69.28, 138.63 out-out out 11.9632 Saltbr-out 7.7849 HRD-out -148.79, 112.09 -68.12, -80.01 out-out-out SNCooo out-out ActLoopNT-out 8.0165 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 137.49 APE8-dihe-in -74.84, 138.8 APE8-rot-out 199.32 APE67-dihe-in -50.64, -36.72 -89.13, -8.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.2314 None None None XRAY 2.79 0.229 0.306 A 282.0 252.0 10 26 16 10 [[133, 383]] 1.0 4c3r CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6C83B O14965 127 388 403.0 ACP:501 ATPlike Inactive DFGinter 7.3169 8.5877 None -129.69, 90.85 -100.04, 101.37 -135.34, 999.0 303.1, 99.49 999.0, 999.0 out-out out 12.1149 Saltbr-out 10.0494 HRD-out -96.09, 116.19 -110.78, 111.97 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -90.23 APE8-dihe-out -77.58, -0.58 APE8-rot-out 85.03 APE67-dihe-in -69.49, -5.14 -61.84, -44.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.4721 None None None XRAY 2.55 0.268 0.322 B 285.0 247.0 15 26 11 15 [[133, 383]] 1.0 6c83 CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6C83A O14965 127 389 403.0 ACP:501 ATPlike Inactive None 999.0 999.0 None -115.58, 146.0 -134.74, 164.64 -155.95, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.2939 Saltbr-none 999.0 HRD-out 57.31, 86.65 -118.52, 133.44 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -76.52 APE8-dihe-out -81.29, 5.34 APE8-rot-out 166.86 APE67-dihe-in -68.45, -16.44 -75.67, -23.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.2563 None None None XRAY 2.55 0.268 0.322 A 285.0 248.0 15 26 11 15 [[133, 383]] 1.0 6c83 CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK DAPK1 DAPK1_HUMAN 3ZXTB P53355 7 276 1430.0 ACP:1279 ATPlike None DFGin 6.5753 14.0674 BLAminus -121.46, -170.78 56.12, 80.76 -103.93, 17.27 282.46, 79.2 -56.39, -19.56 in-in in 8.6799 Saltbr-in 2.544 HRD-in -82.72, -41.2 65.14, 3.07 in-in-none SNCiin in-none ActLoopNT-in 2.9485 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -71.62 APE8-rot-none 999.0 APE67-dihe-in -62.85, -24.88 -49.25, -41.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 B 285.0 253.0 17 27 17 10 [[13, 275]] 1.0 3zxt CAMK_DAPK1_HUMAN CAMK 5.5e-95 323.5 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3ZXTC P53355 5 276 1430.0 ACP:1278 ATPlike None DFGin 6.7644 14.238 BLAminus -125.03, -178.44 64.54, 79.35 -91.9, 24.57 287.83, 76.0 -66.08, -19.72 in-in in 9.3921 Saltbr-in 2.7185 HRD-in -72.23, -37.44 57.47, 4.52 in-in-none SNCiin in-none ActLoopNT-in 3.0967 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -39.65, -42.12 999.0, -61.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 C 285.0 259.0 13 27 16 11 [[13, 275]] 1.0 3zxt CAMK_DAPK1_HUMAN CAMK 5.5e-95 323.5 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3ZXTD P53355 7 276 1430.0 ACP:1277 ATPlike None DFGin 6.8657 14.6449 BLAminus -115.85, 173.32 73.06, 78.3 -92.76, 17.5 283.87, 68.26 -68.46, 25.44 in-in in 9.3064 Saltbr-in 2.6506 HRD-in -83.16, -46.35 65.92, 13.4 in-in-none SNCiin in-none ActLoopNT-in 3.1078 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -20.61 APE8-rot-none 999.0 APE67-dihe-in -90.53, -15.22 -91.11, -7.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 D 285.0 245.0 25 27 17 10 [[13, 275]] 1.0 3zxt CAMK_DAPK1_HUMAN CAMK 5.5e-95 323.5 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3ZXTA P53355 7 276 1430.0 ACP:1277 ATPlike Inactive DFGin 6.5391 14.0575 BLBminus -116.48, -174.8 63.15, 89.03 -105.65, -162.71 284.37, 74.81 49.59, 38.57 in-in in 8.9136 Saltbr-in 3.2081 HRD-in -74.82, -48.06 69.59, 6.45 in-in-none SNCiin in-none ActLoopNT-in 2.7248 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -35.07 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 A 285.0 249.0 21 27 15 12 [[13, 275]] 1.0 3zxt CAMK_DAPK1_HUMAN CAMK 5.5e-95 323.5 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CK1 CSNK1D KC1D_HUMAN 6RU6A P48730 3 294 415.0 ACP:60301 ATPlike Active DFGin 6.4361 15.2637 BLAminus -136.56, 176.84 69.53, 73.53 -93.66, 24.95 289.84, 81.36 -61.77, -30.96 in-in in 7.9234 Saltbr-in 2.7889 HRD-in -77.83, -55.12 76.08, 12.52 in-in-in SNCiii in-in ActLoopNT-in 2.8503 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.64, 119.59 APE9-dihe-na 102.6, -136.74 APE8-dihe-in -117.46, 127.27 APE8-rot-in 311.09 APE67-dihe-in -57.82, -37.85 -53.66, -47.41 APE12-dist-in 12.3149 APE11-dist-in 11.9084 APE10-dist-in 6.4806 APE9-dist-in 3.5052 None None None XRAY 2.05 0.213 0.257 A 296.0 288.0 4 35 35 0 [[9, 275]] 1.0 6ru6 CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU6B P48730 3 294 415.0 ACP:60301 ATPlike None DFGin 6.5901 15.1558 BLAminus -129.63, 177.25 73.9, 71.28 -92.31, 21.27 283.76, 74.29 -58.84, -31.38 in-in in 7.8176 Saltbr-in 2.7964 HRD-in -76.32, -55.32 74.02, 14.82 in-in-none SNCiin in-none ActLoopNT-in 2.8603 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -126.17 APE8-dihe-in -104.51, 127.76 APE8-rot-in 311.88 APE67-dihe-in -57.59, -35.09 -58.93, -44.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.9414 None None None XRAY 2.05 0.213 0.257 B 296.0 278.0 14 35 27 8 [[9, 275]] 1.0 6ru6 CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CMGC CSNK2A1 CSK21_HUMAN 4NH1A P68400 3 332 391.0 ACP:403 ATPlike Inactive DFGin 7.5389 16.0514 BLAminus -114.39, -169.88 57.86, 83.41 -112.16, 31.33 299.65, 85.49 -75.44, -39.86 in-in in 9.2778 Saltbr-in 2.773 HRD-in -89.66, -46.45 59.34, 26.3 in-in-out SNCiio in-out ActLoopNT-in 2.9028 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.56, 170.73 APE9-dihe-na 63.23, 162.58 APE8-dihe-in -68.16, 150.73 APE8-rot-out 180.05 APE67-dihe-in -73.61, -11.12 -57.46, -41.94 APE12-dist-in 12.7146 APE11-dist-in 10.5288 APE10-dist-in 6.0584 APE9-dist-in 3.3234 None None None XRAY 3.3 0.215 0.251 A 335.0 330.0 0 27 27 0 [[39, 324]] 1.0 4nh1 CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 4NH1B P68400 2 333 391.0 ACP:404 ATPlike Inactive DFGin 7.5341 16.0013 BLAminus -114.45, -169.84 57.84, 82.99 -112.41, 30.84 300.31, 85.61 -75.38, -39.92 in-in in 9.2314 Saltbr-in 2.7742 HRD-in -90.12, -46.63 59.22, 26.59 in-in-out SNCiio in-out ActLoopNT-in 2.9537 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.21, 170.34 APE9-dihe-na 63.1, 162.47 APE8-dihe-in -68.11, 151.28 APE8-rot-out 180.18 APE67-dihe-in -73.01, -10.91 -57.19, -42.14 APE12-dist-in 12.652 APE11-dist-in 10.5276 APE10-dist-in 5.9918 APE9-dist-in 3.3647 None None None XRAY 3.3 0.215 0.251 B 335.0 332.0 0 27 27 0 [[39, 324]] 1.0 4nh1 CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC MAPK1 MK01_HUMAN 5V60A P28482 10 358 360.0 ACP:401 ATPlike Active DFGin 6.6686 14.8874 BLAminus -124.21, -175.27 60.56, 75.29 -91.11, 25.45 286.11, 68.09 -67.4, -23.76 in-in in 9.2691 Saltbr-in 3.0882 HRD-in -75.88, -52.24 69.24, 12.32 in-in-in SNCiii in-in ActLoopNT-in 2.9513 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -89.66, 171.23 APE9-dihe-na 66.7, 168.41 APE8-dihe-in -89.68, 141.19 APE8-rot-in 301.48 APE67-dihe-in -66.12, -19.67 -43.41, -50.15 APE12-dist-in 12.5737 APE11-dist-in 11.0864 APE10-dist-in 6.6326 APE9-dist-in 2.9874 None TPO185,PTR187 TPO185,PTR187 XRAY 2.18 0.193 0.226 A 356.0 349.0 0 31 31 0 [[25, 313]] 1.0 5v60 CMGC_MAPK1_HUMAN CMGC 8.8e-86 293.8 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK10 MK10_HUMAN 6EQ9B P53779 47 400 464.0 ACP:502 ATPlike Inactive DFGin 3.8485 14.5358 ABAminus -85.08, -18.98 -157.51, 177.19 -105.91, 17.98 303.5, 84.3 71.4, -149.1 in-in in 9.644 Saltbr-in 2.8818 HRD-in -75.97, -57.51 71.23, 0.13 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 107.58 APE8-dihe-in -64.66, 120.8 APE8-rot-in 307.67 APE67-dihe-in -65.89, -19.34 -114.84, 1.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0426 None None None XRAY 1.83 0.207 0.252 B 367.0 332.0 14 27 13 14 [[64, 359]] 1.0 6eq9 CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 6EQ9A P53779 46 400 464.0 ACP:505,C15:506 ATPlike,Allosteric Inactive DFGin 3.763 14.1786 ABAminus -90.84, -25.71 -146.46, -174.02 -119.81, 8.04 305.39, 99.67 64.39, -162.69 in-out in 9.6534 Saltbr-out 3.9166 HRD-in -74.99, -56.85 72.96, -15.02 out-out-out SNCooo out-out ActLoopNT-out 6.2848 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -45.37 APE8-dihe-in -112.64, 106.03 APE8-rot-in 290.72 APE67-dihe-in -70.8, -9.5 -110.9, 2.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.5168 None None None XRAY 1.83 0.207 0.252 A 367.0 350.0 5 27 22 5 [[64, 359]] 1.0 6eq9 CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 8VTFA P53779 45 400 464.0 A1ACP:1101 Type1 Inactive DFGin 4.1231 14.4365 ABAminus -80.88, -55.79 -105.49, 178.52 -116.12, 4.6 292.24, 108.11 97.34, -165.3 out-out out 10.1768 Saltbr-out 6.0587 HRD-in -81.08, -68.87 73.64, -1.6 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -88.73, 154.5 APE9-dihe-na -85.68, 161.75 APE8-dihe-in -104.45, 122.83 APE8-rot-in 288.76 APE67-dihe-in -66.26, -13.42 -118.39, 6.09 APE12-dist-out 21.2043 APE11-dist-out 17.1276 APE10-dist-out 16.3671 APE9-dist-out 11.6243 None None None XRAY 2.4 0.258 0.297 A 464.0 346.0 5 27 22 5 [[64, 359]] 1.0 8vtf CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
OTHER RNASEL RN5A_HUMAN 4OAVB Q05823 24 717 741.0 ACP:801 ATPlike Pseudo DFGin 6.4754 12.3669 BLAminus -139.92, -178.5 65.74, 91.26 -114.98, 14.68 309.18, 101.1 -77.21, 3.69 in-in in 6.9053 Saltbr-in 2.7395 HRD-in -87.38, -45.25 69.13, -2.14 in-in-na SNCiia in-na ActLoopNT-in 3.0597 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.56, 102.63 APE9-dihe-na -56.52, -19.13 APE8-dihe-na -66.25, -31.04 APE8-rot-na 198.81 APE67-dihe-na -66.21, -44.37 -71.69, -39.0 APE12-dist-na 15.2929 APE11-dist-na 17.0118 APE10-dist-na 15.0202 APE9-dist-na 14.3961 H672N None None XRAY 2.1 0.2 0.229 B 699.0 673.0 8 20 20 0 [[353, 594]] 1.0 4oav OTHER_RNASEL_HUMAN RNASEL 4.1e-136 459.9 1.0 242.0 242.0 502 503 504 506 508 392 404 408 482 484 483 485.0 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
OTHER RNASEL RN5A_HUMAN 4OAVD Q05823 26 719 741.0 ACP:1001 ATPlike Pseudo DFGin 6.5588 12.4049 BLAminus -138.71, -178.08 64.72, 95.25 -118.8, 14.99 306.98, 96.56 -77.32, 4.45 in-in in 6.904 Saltbr-in 2.919 HRD-in -73.82, -49.38 73.22, -2.68 in-in-na SNCiia in-na ActLoopNT-in 2.9151 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.59, 112.49 APE9-dihe-na -62.01, -29.18 APE8-dihe-na -62.89, -32.55 APE8-rot-na 188.49 APE67-dihe-na -70.07, -38.9 -67.42, -39.34 APE12-dist-na 14.651 APE11-dist-na 16.869 APE10-dist-na 14.6353 APE9-dist-na 14.3519 H672N None None XRAY 2.1 0.2 0.229 D 699.0 674.0 7 20 20 0 [[353, 594]] 1.0 4oav OTHER_RNASEL_HUMAN RNASEL 4.1e-136 459.9 1.0 242.0 242.0 502 503 504 506 508 392 404 408 482 484 483 485.0 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
STE MAP2K1 MP2K1_HUMAN 6U2GA Q02750 43 383 393.0 ACP:901 ATPlike Inactive DFGin 5.8079 13.8406 BLBplus -143.7, 174.8 53.7, 47.78 -98.62, 156.52 46.78, 97.62 -76.59, 70.13 out-out out 15.3736 Saltbr-out 14.8686 HRD-in -83.28, -55.76 76.37, -10.26 out-out-out SNCooo out-out ActLoopNT-out 9.207 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -64.24, 146.48 APE9-dihe-na -101.23, -173.03 APE8-dihe-out -114.34, -9.62 APE8-rot-out 55.71 APE67-dihe-out -148.86, 141.69 -149.81, 176.75 APE12-dist-out 19.1865 APE11-dist-out 17.9815 APE10-dist-out 22.1053 APE9-dist-out 12.9996 None None None XRAY 2.886 0.231 0.276 A 394.0 309.0 32 26 26 0 [[68, 361]] 1.0 6u2g STE_MAP2K1_HUMAN STE 2.4e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNEA Q02750 63 379 393.0 ACP:901,573:903 ATPlike,Type1 Inactive DFGin 6.3821 13.6901 BLBplus -140.61, 176.72 54.72, 28.13 -81.46, 161.59 52.56, 86.0 -81.78, 73.09 out-out out 15.4969 Saltbr-out 15.7793 HRD-in -64.01, -56.53 90.31, -35.13 out-out-out SNCooo out-out ActLoopNT-out 9.2902 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -73.66, 137.78 APE9-dihe-na -84.79, 178.97 APE8-dihe-out -113.02, -24.38 APE8-rot-out 49.94 APE67-dihe-out -153.46, 146.56 -142.39, -172.52 APE12-dist-out 17.192 APE11-dist-out 21.6533 APE10-dist-out 23.7976 APE9-dist-out 13.4974 None None None XRAY 2.848 0.186 0.24 A 341.0 286.0 31 26 26 0 [[68, 361]] 1.0 4mne STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNED Q02750 66 382 393.0 ACP:901,573:903 ATPlike,Type1 Inactive DFGin 6.2631 13.8726 BLBplus -124.78, 174.1 56.33, 33.25 -88.39, 154.28 50.46, 89.74 -73.02, 74.09 out-out out 15.5381 Saltbr-out 15.6141 HRD-in -64.9, -49.38 74.62, -12.51 out-out-out SNCooo out-out ActLoopNT-out 9.0432 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -65.65, 150.79 APE9-dihe-na -95.28, -163.25 APE8-dihe-out -122.75, -11.87 APE8-rot-out 68.42 APE67-dihe-out -159.06, 142.59 -161.08, -176.92 APE12-dist-out 17.403 APE11-dist-out 21.784 APE10-dist-out 23.8522 APE9-dist-out 13.6322 None None None XRAY 2.848 0.186 0.24 D 341.0 285.0 32 26 26 0 [[68, 361]] 1.0 4mne STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4AN9A Q02750 61 381 393.0 ACP:61382,2P7:61384 ATPlike,Type3 Inactive DFGin 6.3107 13.7515 BLBplus -147.68, 174.84 72.25, 33.73 -84.91, 163.57 42.25, 107.87 -96.68, 81.85 out-out out 15.6879 Saltbr-out 15.1088 HRD-in -67.38, -51.77 90.36, -23.63 out-out-out SNCooo out-out ActLoopNT-out 9.4167 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_onoo APE10-dihe-na 999.0, 140.8 APE9-dihe-na -91.12, -166.68 APE8-dihe-in -63.03, 65.46 APE8-rot-in 350.49 APE67-dihe-in -61.1, -23.55 -42.53, -42.27 APE12-dist-out 17.6262 APE11-dist-none 999.0 APE10-dist-out 19.7035 APE9-dist-out 7.8575 S218E,S222E,G328A None None XRAY 2.8 0.205 0.313 A 301.0 278.0 1 26 25 1 [[68, 361]] 1.0 4an9 STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNEE Q02750 62 379 393.0 ACP:901,573:903 ATPlike,Type3 Inactive DFGin 6.3012 13.7407 BLBplus -139.17, 176.14 61.58, 40.21 -96.23, 153.1 47.97, 96.35 -69.87, 64.71 out-out out 15.7956 Saltbr-out 16.1573 HRD-in -84.17, -39.22 69.48, -27.4 out-out-out SNCooo out-out ActLoopNT-out 9.2771 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -76.04, 124.0 APE9-dihe-na -78.04, -178.79 APE8-dihe-out -111.0, -36.1 APE8-rot-out 69.56 APE67-dihe-out -140.43, 146.63 -132.48, 167.21 APE12-dist-out 17.6629 APE11-dist-out 21.7751 APE10-dist-out 24.2369 APE9-dist-out 13.5531 None None None XRAY 2.848 0.186 0.24 E 341.0 286.0 32 26 26 0 [[68, 361]] 1.0 4mne STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNEH Q02750 66 380 393.0 ACP:901,573:903,573:904 ATPlike,Type3,Allosteric Inactive DFGin 6.3776 13.8909 BLBplus -149.03, 175.24 52.75, 36.33 -93.4, 157.98 53.98, 84.28 -78.54, 56.84 out-out out 15.8147 Saltbr-out 15.4559 HRD-in -72.48, -51.28 80.05, -1.12 out-out-out SNCooo out-out ActLoopNT-out 9.1113 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -63.87, 146.83 APE9-dihe-na -98.86, 164.39 APE8-dihe-out -71.61, -59.39 APE8-rot-in 294.12 APE67-dihe-out -156.42, 156.79 -128.0, -169.25 APE12-dist-out 17.7474 APE11-dist-out 21.8877 APE10-dist-out 24.1565 APE9-dist-out 13.6645 None None None XRAY 2.848 0.186 0.24 H 341.0 275.0 40 26 26 0 [[68, 361]] 1.0 4mne STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4AN2A Q02750 61 381 393.0 EUI:61382,ACP:61383 Type3,ATPlike Inactive DFGin 6.5059 13.6203 BLBplus -122.79, 178.99 56.84, 40.15 -92.39, 167.6 39.23, 93.66 -89.21, 72.99 out-out out 15.4473 Saltbr-out 15.2762 HRD-in -67.56, -54.42 79.08, -11.1 out-out-out SNCooo out-out ActLoopNT-out 9.0354 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -98.27, 63.09 APE9-dihe-na -45.72, -71.67 APE8-dihe-in -89.8, 67.42 APE8-rot-out 5.41 APE67-dihe-in -66.45, -14.82 -49.39, -42.64 APE12-dist-out 17.4744 APE11-dist-out 16.5588 APE10-dist-out 17.0301 APE9-dist-out 8.7163 S218E,S222E,G328A None None XRAY 2.5 0.215 0.299 A 301.0 279.0 0 26 26 0 [[68, 361]] 1.0 4an2 STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4ANBA Q02750 61 381 393.0 YQY:60501,ACP:60502 Type3,ATPlike Inactive DFGin 6.3584 13.3927 BLBplus -107.54, 172.13 64.32, 39.17 -93.81, 160.33 38.34, 94.07 -83.38, 74.0 out-out out 15.2238 Saltbr-out 14.8172 HRD-in -75.33, -47.65 77.84, -16.31 out-out-out SNCooo out-out ActLoopNT-out 9.4144 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -89.14, -39.83 APE9-dihe-na 89.67, -158.68 APE8-dihe-in -87.88, 72.09 APE8-rot-out 15.75 APE67-dihe-in -64.72, -18.82 -69.34, -22.58 APE12-dist-out 17.552 APE11-dist-out 16.8932 APE10-dist-out 19.8413 APE9-dist-out 8.65 S218E,S222E,G328A None None XRAY 2.2 0.23 0.296 A 301.0 279.0 0 26 26 0 [[68, 361]] 1.0 4anb STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
TKL BRAF BRAF_HUMAN 6U2GB P15056 451 722 766.0 ACP:901 ATPlike Inactive DFGin 6.1502 13.9094 BLBplus -127.14, -173.09 46.65, 53.2 -113.93, 152.92 52.73, 94.7 72.25, -152.99 out-out out 14.6056 Saltbr-out 12.7046 HRD-in -59.19, -53.53 76.48, -9.73 out-out-out SNCooo out-out ActLoopNT-out 9.495 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -146.07, 161.59 APE9-dihe-na 90.18, -141.72 APE8-dihe-in -101.38, 139.04 APE8-rot-out 180.97 APE67-dihe-in -60.58, -31.67 -70.85, -22.56 APE12-dist-out 15.3356 APE11-dist-out 15.7094 APE10-dist-out 13.5919 APE9-dist-out 9.8922 None None None XRAY 2.886 0.231 0.276 B 307.0 264.0 8 30 22 8 [[457, 716]] 1.0 6u2g TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL RIPK2 RIPK2_HUMAN 5NG0A O43353 6 300 540.0 ACP:1000 ATPlike Inactive DFGin 5.8784 14.1777 BLAminus -123.27, -179.27 62.78, 77.58 -93.4, 20.77 286.94, 75.81 -61.85, -28.6 in-in in 8.2049 Saltbr-in 2.7453 HRD-in -73.28, -52.62 66.02, 10.49 in-in-out SNCiio in-out ActLoopNT-in 2.8467 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 157.46 APE8-dihe-in -72.18, 143.02 APE8-rot-out 185.7 APE67-dihe-in -65.61, -24.81 -104.28, 1.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8005 L294F None None XRAY 2.0 0.171 0.191 A 304.0 274.0 21 33 18 15 [[18, 292]] 1.0 5ng0 TKL_RIPK2_HUMAN TKL 4.1e-73 252.1 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5NG0B O43353 5 299 540.0 ACP:401 ATPlike Inactive DFGin 5.8866 14.1774 BLAminus -123.03, -178.96 62.29, 77.78 -94.31, 21.44 286.41, 77.58 -63.12, -27.82 in-in in 8.1596 Saltbr-in 2.756 HRD-in -74.08, -51.77 69.59, 3.54 in-in-out SNCiio in-out ActLoopNT-in 2.8525 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -72.33, -175.56 APE9-dihe-na 154.16, -172.85 APE8-dihe-in -105.14, 130.27 APE8-rot-in 300.55 APE67-dihe-in -61.64, -28.91 -51.09, -46.77 APE12-dist-in 11.85 APE11-dist-out 7.4022 APE10-dist-in 6.0202 APE9-dist-in 3.3421 L294F None None XRAY 2.0 0.171 0.191 B 304.0 282.0 13 33 23 10 [[18, 292]] 1.0 5ng0 TKL_RIPK2_HUMAN TKL 4.1e-73 252.1 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5AR3A O43353 6 310 540.0 ACP:1311 ATPlike Inactive DFGin 5.9241 14.2881 BLAminus -133.03, 175.56 72.21, 76.24 -97.68, 34.32 293.9, 86.68 -66.76, -37.47 in-in in 7.9943 Saltbr-in 2.7998 HRD-in -61.0, -40.82 51.84, 8.75 in-in-out SNCiio in-out ActLoopNT-in 2.841 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -117.65 APE9-dihe-na 164.28, -57.84 APE8-dihe-in -114.77, 107.38 APE8-rot-out 185.6 APE67-dihe-in -64.24, -32.65 -95.4, 6.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.7091 APE9-dist-out 10.828 None None None XRAY 3.23 0.192 0.254 A 326.0 279.0 26 33 19 14 [[18, 292]] 1.0 5ar3 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5AR3B O43353 6 310 540.0 ACP:1311 ATPlike Inactive DFGin 5.8705 14.4182 BLAminus -128.31, 176.09 65.92, 78.1 -98.91, 35.33 294.64, 70.55 -68.55, -48.71 in-in in 8.021 Saltbr-in 2.8795 HRD-in -65.19, -46.65 55.58, 8.54 in-in-out SNCiio in-out ActLoopNT-in 2.8614 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.98 APE8-rot-out 49.06 APE67-dihe-in -39.82, -41.25 -97.08, -7.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.23 0.192 0.254 B 326.0 276.0 29 33 17 16 [[18, 292]] 1.0 5ar3 TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TYR EPHA2 EPHA2_HUMAN 7KJAB P29317 590 965 976.0 ACP:61003 ATPlike None DFGin 5.9498 15.3185 BLAminus -132.83, -173.32 70.39, 83.56 -118.78, 24.56 302.85, 98.09 -89.22, 999.0 in-in in 8.6069 Saltbr-in 3.1653 HRD-in -76.56, -48.38 78.92, -16.95 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.75 APE8-rot-na 32.08 APE67-dihe-in -69.28, -11.58 -65.6, -29.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.19 0.217 B 390.0 349.0 22 31 11 20 [[613, 873]] 1.0 7kja TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 7KJCA P29317 590 976 976.0 ACP:61001 ATPlike Inactive DFGin 5.8783 14.9304 BLBminus -137.77, -170.41 70.81, 83.37 -119.58, 163.56 301.23, 100.14 146.26, -161.86 in-in in 8.3547 Saltbr-in 3.0316 HRD-in -75.87, -47.34 76.1, -11.46 in-out-none SNCion out-none ActLoopNT-out 9.6694 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 107.51 APE9-dihe-in -145.96, 148.03 APE8-dihe-in -73.29, 89.61 APE8-rot-na 29.38 APE67-dihe-in -67.75, -13.33 -62.67, -32.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.5466 APE9-dist-in 6.6396 S901E None None XRAY 2.3 0.19 0.226 A 390.0 373.0 8 31 26 5 [[613, 873]] 1.0 7kjc TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 7KJCB P29317 590 965 976.0 ACP:61002 ATPlike Inactive DFGin 5.9635 15.2035 BLBminus -132.91, -166.6 60.51, 83.21 -117.48, 163.92 299.39, 100.57 145.47, 999.0 in-in in 8.4672 Saltbr-in 3.1302 HRD-in -75.7, -46.49 74.32, -9.38 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 86.32 APE8-rot-na 29.03 APE67-dihe-in -66.96, -12.86 -66.13, -32.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 S901E None None XRAY 2.3 0.19 0.226 B 390.0 347.0 23 31 11 20 [[613, 873]] 1.0 7kjc TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 7KJAA P29317 590 976 976.0 ACP:61002 ATPlike Inactive DFGin 5.763 14.7694 BLBminus -129.59, -174.19 75.99, 88.0 -122.87, 170.51 304.47, 101.43 99.06, 999.0 in-in in 8.4239 Saltbr-in 3.0553 HRD-in -76.77, -48.29 79.69, -17.22 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.1 APE8-rot-na 32.23 APE67-dihe-in -70.25, -11.59 -65.39, -29.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.19 0.217 A 390.0 361.0 20 31 11 20 [[613, 873]] 1.0 7kja TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR FGFR1 FGFR1_HUMAN 3GQIA P11362 464 770 822.0 ACP:775 ATPlike Active DFGin 6.4659 13.9462 BLAminus -126.61, -175.83 60.19, 72.36 -91.08, 18.42 288.73, 91.63 -64.67, -15.4 in-in in 7.7514 Saltbr-in 2.6904 HRD-in -77.5, -49.87 72.48, -2.68 in-in-in SNCiii in-in ActLoopNT-in 2.9611 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.96, 135.34 APE9-dihe-in -149.19, 136.62 APE8-dihe-in -75.51, 66.48 APE8-rot-na 33.4 APE67-dihe-in -65.08, -11.82 -44.91, -41.18 APE12-dist-na 14.0832 APE11-dist-na 11.2584 APE10-dist-na 10.1277 APE9-dist-in 7.1373 C488A,Y583F,C584S,Y585F PTR653,PTR654,PTR766 PTR653,PTR654,PTR766 XRAY 2.5 0.249 0.289 A 326.0 307.0 0 30 30 0 [[478, 756]] 1.0 3gqi TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR2 FGFR2_HUMAN 2PWLA P21802 467 764 821.0 ACP:300 ATPlike Inactive DFGin 6.4511 14.1775 BLAminus -131.61, -167.38 56.51, 73.64 -92.98, 26.06 293.6, 74.93 -63.45, -20.7 in-in in 7.5864 Saltbr-in 2.8562 HRD-in -77.4, -49.09 71.28, -7.85 in-in-out SNCiio in-out ActLoopNT-in 2.8847 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.03, 20.75 APE9-dihe-in -94.74, 135.38 APE8-dihe-in -58.69, 123.68 APE8-rot-na 326.81 APE67-dihe-in -69.99, -5.92 -52.74, -45.54 APE12-dist-na 10.002 APE11-dist-na 10.6782 APE10-dist-na 7.4317 APE9-dist-in 4.749 C491A,N549H None None XRAY 2.4 0.21 0.238 A 324.0 284.0 14 30 30 0 [[481, 759]] 1.0 2pwl TYR_FGFR2_HUMAN TYR 3.1e-104 353.8 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PWLB P21802 468 765 821.0 ACP:300 ATPlike Inactive DFGin 6.4391 14.2798 BLAminus -131.94, -168.62 54.17, 75.02 -93.02, 25.01 292.99, 76.23 -61.28, -25.59 in-in in 7.6919 Saltbr-in 3.0703 HRD-in -69.87, -47.96 69.48, -8.93 in-in-out SNCiio in-out ActLoopNT-in 2.9161 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.23, 16.85 APE9-dihe-in -95.43, 136.0 APE8-dihe-in -55.13, 121.27 APE8-rot-na 324.13 APE67-dihe-in -66.61, -7.86 -55.94, -44.16 APE12-dist-na 10.0887 APE11-dist-na 10.8542 APE10-dist-na 7.4849 APE9-dist-in 4.9122 C491A,N549H None None XRAY 2.4 0.21 0.238 B 324.0 286.0 12 30 30 0 [[481, 759]] 1.0 2pwl TYR_FGFR2_HUMAN TYR 3.1e-104 353.8 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J96B P21802 462 766 821.0 ACP:803 ATPlike Inactive DFGin 6.422 14.0694 BLAminus -135.07, -171.17 49.96, 77.75 -93.13, 20.28 283.65, 85.2 -66.67, -18.8 in-out in 7.205 Saltbr-out 3.6908 HRD-in -86.85, -47.88 76.0, -13.66 out-in-out SNCoio in-out ActLoopNT-in 2.8113 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.69, 28.85 APE9-dihe-in -99.38, 128.67 APE8-dihe-in -54.56, 125.51 APE8-rot-na 329.88 APE67-dihe-in -70.35, -5.29 -58.48, -39.96 APE12-dist-na 14.7243 APE11-dist-na 10.1541 APE10-dist-na 7.5072 APE9-dist-in 4.9304 C491A,K659M None None XRAY 2.297 0.178 0.219 B 324.0 305.0 0 30 30 0 [[481, 759]] 1.0 4j96 TYR_FGFR2_HUMAN TYR 2.7e-104 354.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J98B P21802 461 764 821.0 ACP:804 ATPlike Inactive DFGin 6.5497 14.0416 BLAminus -130.09, -172.54 52.51, 78.98 -94.32, 21.96 285.07, 86.18 -63.61, -22.45 in-in in 7.1129 Saltbr-in 3.0165 HRD-in -86.21, -48.16 74.7, -12.01 in-in-out SNCiio in-out ActLoopNT-in 2.8085 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.22, 26.63 APE9-dihe-in -99.48, 124.84 APE8-dihe-in -50.97, 125.51 APE8-rot-na 328.99 APE67-dihe-in -68.16, -7.57 -60.28, -41.11 APE12-dist-na 15.0958 APE11-dist-na 10.4175 APE10-dist-na 7.5796 APE9-dist-in 4.8265 C491A,K659Q None None XRAY 2.307 0.19 0.234 B 324.0 304.0 0 30 30 0 [[481, 759]] 1.0 4j98 TYR_FGFR2_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVFA P21802 467 765 821.0 ACP:60300 ATPlike Active DFGin 6.0481 13.8212 BLAminus -138.88, -175.17 54.67, 80.46 -90.11, 24.33 291.08, 76.38 -54.38, -36.38 in-in in 7.9134 Saltbr-in 2.7695 HRD-in -85.37, -48.4 70.03, 0.26 in-in-in SNCiii in-in ActLoopNT-in 2.8789 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.94, 115.27 APE9-dihe-in -125.87, 160.91 APE8-dihe-in -74.41, 68.1 APE8-rot-na 35.92 APE67-dihe-in -70.82, -9.54 -47.44, -41.99 APE12-dist-na 15.1398 APE11-dist-na 11.6492 APE10-dist-na 11.6038 APE9-dist-in 7.1679 C491A PTR586,PTR656,PTR657 PTR586,PTR656,PTR657 XRAY 1.8 0.251 0.265 A 334.0 288.0 11 30 30 0 [[481, 759]] 1.0 2pvf TYR_FGFR2_HUMAN TYR 2.2e-104 354.3 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 3CLYA P21802 468 772 821.0 ACP:61803 ATPlike Active DFGin 6.2295 14.1831 BLAminus -138.78, -172.76 51.4, 79.79 -91.29, 32.46 290.47, 75.81 -61.86, -29.26 in-in in 7.6608 Saltbr-in 2.6208 HRD-in -89.86, -45.92 68.93, -0.84 in-in-in SNCiii in-in ActLoopNT-in 2.8691 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.79, 139.96 APE9-dihe-in -131.36, 152.18 APE8-dihe-in -76.17, 66.16 APE8-rot-na 37.1 APE67-dihe-in -66.78, -6.73 -47.95, -40.48 APE12-dist-na 13.2533 APE11-dist-na 10.4024 APE10-dist-na 11.0968 APE9-dist-in 6.9127 C491A PTR656,PTR657 PTR656,PTR657 XRAY 2.0 0.216 0.247 A 334.0 291.0 14 30 30 0 [[481, 759]] 1.0 3cly TYR_FGFR2_HUMAN TYR 2.2e-104 354.3 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J99A P21802 466 764 821.0 ACP:802 ATPlike Inactive DFGin 6.7153 14.1397 BLAminus -130.96, -174.69 58.83, 77.45 -92.73, 19.29 291.78, 87.39 -60.03, -34.11 in-in in 7.6098 Saltbr-in 2.8446 HRD-in -78.19, -48.52 73.01, -4.76 in-in-out SNCiio in-out ActLoopNT-in 2.8606 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.36, 29.03 APE9-dihe-in -109.75, 138.54 APE8-dihe-in -57.3, 116.33 APE8-rot-na 330.48 APE67-dihe-in -70.7, -10.42 -57.47, -40.52 APE12-dist-na 15.0402 APE11-dist-na 11.232 APE10-dist-na 7.9723 APE9-dist-in 5.1297 C491A,K659T None None XRAY 1.847 0.206 0.24 A 324.0 280.0 19 30 26 4 [[481, 759]] 1.0 4j99 TYR_FGFR2_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J99B P21802 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.666 14.1883 BLAminus -133.21, -176.0 58.56, 76.97 -94.04, 15.78 292.83, 99.53 -58.91, -32.83 in-in in 7.584 Saltbr-in 2.6156 HRD-in -76.65, -48.86 73.31, -6.92 in-in-out SNCiio in-out ActLoopNT-in 2.9004 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -118.89, 30.62 APE9-dihe-in -108.84, 137.25 APE8-dihe-in -57.12, 118.19 APE8-rot-na 330.19 APE67-dihe-in -70.1, -10.12 -57.01, -39.76 APE12-dist-na 14.1481 APE11-dist-na 11.074 APE10-dist-na 8.0074 APE9-dist-in 5.1802 C491A,K659T None None XRAY 1.847 0.206 0.24 B 324.0 291.0 7 30 30 0 [[481, 759]] 1.0 4j99 TYR_FGFR2_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J99C P21802 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.8355 14.168 BLAminus -131.87, -175.54 59.17, 75.71 -91.42, 19.92 291.67, 85.71 -59.92, -32.59 in-in in 7.6282 Saltbr-in 2.9134 HRD-in -76.88, -47.72 74.23, -7.36 in-in-out SNCiio in-out ActLoopNT-in 2.8938 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.66, 30.6 APE9-dihe-in -110.19, 138.06 APE8-dihe-in -55.44, 118.46 APE8-rot-na 330.51 APE67-dihe-in -70.73, -10.29 -57.12, -38.65 APE12-dist-na 14.1212 APE11-dist-na 10.9538 APE10-dist-na 8.0502 APE9-dist-in 5.3615 C491A,K659T None None XRAY 1.847 0.206 0.24 C 324.0 291.0 7 30 30 0 [[481, 759]] 1.0 4j99 TYR_FGFR2_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J99D P21802 465 764 821.0 ACP:802 ATPlike Inactive DFGin 6.5929 14.159 BLAminus -133.66, -174.57 58.72, 78.56 -92.61, 20.44 290.96, 82.99 -59.4, -33.38 in-in in 7.6313 Saltbr-in 2.6395 HRD-in -78.38, -50.11 73.68, -6.22 in-in-out SNCiio in-out ActLoopNT-in 2.8934 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.76, 31.03 APE9-dihe-in -108.34, 137.61 APE8-dihe-in -55.35, 118.06 APE8-rot-na 330.85 APE67-dihe-in -71.9, -11.56 -55.67, -38.95 APE12-dist-na 999.0 APE11-dist-na 11.135 APE10-dist-na 7.8592 APE9-dist-in 4.9921 C491A,K659T None None XRAY 1.847 0.206 0.24 D 324.0 281.0 19 30 27 3 [[481, 759]] 1.0 4j99 TYR_FGFR2_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVYA P21802 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.7496 14.2737 BLAminus -142.14, -176.01 63.9, 72.69 -96.2, 30.01 293.76, 86.07 -65.9, -30.73 in-in in 7.5474 Saltbr-in 2.8523 HRD-in -84.99, -48.7 74.29, -16.98 in-in-out SNCiio in-out ActLoopNT-in 2.8094 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.15, 32.71 APE9-dihe-in -103.67, 126.67 APE8-dihe-in -51.63, 122.63 APE8-rot-na 323.69 APE67-dihe-in -64.04, -12.74 -56.98, -40.88 APE12-dist-na 14.8138 APE11-dist-na 10.095 APE10-dist-na 7.5375 APE9-dist-in 4.9554 C491A,K659N None None XRAY 2.2 0.236 0.276 A 324.0 288.0 10 30 30 0 [[481, 759]] 1.0 2pvy TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVYB P21802 462 764 821.0 ACP:8002 ATPlike Inactive DFGin 6.635 14.0654 BLAminus -144.27, -177.95 57.14, 77.78 -93.97, 24.89 293.34, 84.21 -55.49, -34.1 in-in in 7.3161 Saltbr-in 2.8469 HRD-in -81.21, -48.71 71.97, -12.52 in-in-out SNCiio in-out ActLoopNT-in 2.8523 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.68, 30.22 APE9-dihe-in -107.46, 135.49 APE8-dihe-in -57.98, 120.91 APE8-rot-na 329.38 APE67-dihe-in -64.69, -5.42 -51.47, -46.8 APE12-dist-na 999.0 APE11-dist-na 10.6935 APE10-dist-na 7.435 APE9-dist-in 5.0657 C491A,K659N None None XRAY 2.2 0.236 0.276 B 324.0 286.0 17 30 24 6 [[481, 759]] 1.0 2pvy TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVYC P21802 462 764 821.0 ACP:802 ATPlike Inactive DFGin 6.6933 14.018 BLAminus -131.41, -174.32 49.42, 82.58 -94.81, 27.78 293.52, 79.4 -60.72, -24.91 in-in in 7.2286 Saltbr-in 3.5766 HRD-in -81.5, -47.6 72.07, -14.53 in-in-out SNCiio in-out ActLoopNT-in 2.7937 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.89, 24.55 APE9-dihe-in -101.87, 134.03 APE8-dihe-in -55.3, 120.87 APE8-rot-na 330.19 APE67-dihe-in -64.04, -6.89 -51.83, -46.76 APE12-dist-na 14.3155 APE11-dist-na 10.3228 APE10-dist-na 7.4377 APE9-dist-in 5.0687 C491A,K659N None None XRAY 2.2 0.236 0.276 C 324.0 285.0 18 30 25 5 [[481, 759]] 1.0 2pvy TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVYD P21802 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.9442 14.2611 BLAminus -139.76, -174.3 61.15, 74.17 -97.41, 31.68 293.81, 79.18 -66.75, -30.92 in-in in 7.2983 Saltbr-in 3.0357 HRD-in -85.65, -49.02 75.46, -18.01 in-in-out SNCiio in-out ActLoopNT-in 2.8112 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.37, 33.11 APE9-dihe-in -102.8, 126.29 APE8-dihe-in -51.84, 123.89 APE8-rot-na 324.49 APE67-dihe-in -63.66, -13.12 -61.69, -37.66 APE12-dist-na 14.8282 APE11-dist-na 10.0923 APE10-dist-na 7.5701 APE9-dist-in 4.9682 C491A,K659N None None XRAY 2.2 0.236 0.276 D 324.0 283.0 15 30 30 0 [[481, 759]] 1.0 2pvy TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J95A P21802 467 764 821.0 ACP:801 ATPlike Inactive DFGin 6.6906 14.0578 BLAminus -131.56, -174.19 63.25, 76.63 -98.25, 22.24 292.31, 85.68 -64.6, -23.3 in-in in 7.7521 Saltbr-in 2.8109 HRD-in -79.93, -52.54 74.87, -4.09 in-in-out SNCiio in-out ActLoopNT-in 2.9917 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.79, 21.67 APE9-dihe-in -99.53, 131.21 APE8-dihe-in -54.93, 120.24 APE8-rot-na 331.68 APE67-dihe-in -73.86, -8.05 -61.39, -39.09 APE12-dist-na 14.7733 APE11-dist-na 10.9527 APE10-dist-na 7.48 APE9-dist-in 4.8674 C491A,K659N None None XRAY 2.377 0.214 0.255 A 324.0 279.0 19 30 26 4 [[481, 759]] 1.0 4j95 TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J95B P21802 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.6767 14.3781 BLAminus -131.79, -176.38 62.78, 77.42 -96.59, 21.6 290.19, 86.46 -65.99, -23.31 in-in in 7.797 Saltbr-in 2.9027 HRD-in -80.06, -52.15 74.05, -5.91 in-in-out SNCiio in-out ActLoopNT-in 2.8975 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.95, 20.73 APE9-dihe-in -101.19, 131.88 APE8-dihe-in -53.9, 121.25 APE8-rot-na 331.03 APE67-dihe-in -73.96, -6.54 -59.67, -39.95 APE12-dist-na 14.9774 APE11-dist-na 11.0211 APE10-dist-na 7.7091 APE9-dist-in 4.8559 C491A,K659N None None XRAY 2.377 0.214 0.255 B 324.0 282.0 15 30 30 0 [[481, 759]] 1.0 4j95 TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J95C P21802 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.762 14.3167 BLAminus -132.19, -176.54 63.57, 76.14 -98.34, 23.39 290.03, 85.39 -65.87, -22.89 in-in in 7.7358 Saltbr-in 2.8246 HRD-in -79.64, -52.73 75.27, -7.0 in-in-out SNCiio in-out ActLoopNT-in 2.9588 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.5, 23.85 APE9-dihe-in -97.28, 128.27 APE8-dihe-in -54.92, 121.79 APE8-rot-na 330.61 APE67-dihe-in -73.19, -7.42 -60.17, -39.19 APE12-dist-na 14.7321 APE11-dist-na 10.3649 APE10-dist-na 7.4131 APE9-dist-in 4.9058 C491A,K659N None None XRAY 2.377 0.214 0.255 C 324.0 281.0 16 30 30 0 [[481, 759]] 1.0 4j95 TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J95D P21802 467 764 821.0 ACP:801 ATPlike Inactive DFGin 6.6005 14.0737 BLAminus -131.84, -175.28 62.91, 77.06 -96.79, 22.82 289.52, 85.1 -64.56, -22.95 in-in in 7.6408 Saltbr-in 2.7469 HRD-in -80.37, -53.3 74.73, -6.2 in-in-out SNCiio in-out ActLoopNT-in 3.0328 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.03, 23.13 APE9-dihe-in -98.93, 130.46 APE8-dihe-in -52.66, 122.62 APE8-rot-na 330.72 APE67-dihe-in -75.07, -8.74 -59.5, -40.3 APE12-dist-na 999.0 APE11-dist-na 10.8037 APE10-dist-na 7.616 APE9-dist-in 4.8025 C491A,K659N None None XRAY 2.377 0.214 0.255 D 324.0 271.0 27 30 19 11 [[481, 759]] 1.0 4j95 TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZ5A P21802 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.2698 14.129 BLAminus -134.55, -165.25 46.14, 76.71 -87.82, 24.61 288.3, 73.06 -57.77, -17.99 in-in in 7.3761 Saltbr-in 2.7198 HRD-in -71.49, -53.18 74.61, -7.33 in-in-out SNCiio in-out ActLoopNT-in 2.9544 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.92, 23.05 APE9-dihe-in -100.29, 130.1 APE8-dihe-in -50.24, 116.35 APE8-rot-na 324.43 APE67-dihe-in -70.43, -5.4 -48.06, -44.87 APE12-dist-na 10.1619 APE11-dist-na 10.8924 APE10-dist-na 7.5553 APE9-dist-in 4.8296 C491A,N549T None None XRAY 2.4 0.214 0.254 A 324.0 280.0 19 30 30 0 [[481, 759]] 1.0 2pz5 TYR_FGFR2_HUMAN TYR 4.5e-104 353.3 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZ5B P21802 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.4195 14.2227 BLAminus -139.02, -170.4 49.42, 74.35 -88.07, 29.83 289.06, 77.09 -65.84, -12.67 in-in in 7.3045 Saltbr-in 2.7727 HRD-in -68.79, -48.45 71.17, -10.83 in-in-out SNCiio in-out ActLoopNT-in 2.9235 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.66, 23.86 APE9-dihe-in -102.44, 130.7 APE8-dihe-in -54.21, 119.21 APE8-rot-na 323.97 APE67-dihe-in -67.2, -7.87 -53.61, -43.12 APE12-dist-na 10.0458 APE11-dist-na 10.8116 APE10-dist-na 7.3934 APE9-dist-in 4.9807 C491A,N549T None None XRAY 2.4 0.214 0.254 B 324.0 280.0 19 30 30 0 [[481, 759]] 1.0 2pz5 TYR_FGFR2_HUMAN TYR 4.5e-104 353.3 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J97A P21802 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.5502 14.1232 BLAminus -139.14, -173.61 59.78, 71.54 -95.85, 23.3 290.64, 88.77 -67.56, -16.73 in-in in 7.3156 Saltbr-in 3.0041 HRD-in -83.97, -47.07 72.51, -7.44 in-in-out SNCiio in-out ActLoopNT-in 2.8773 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.39, 21.13 APE9-dihe-in -97.79, 130.15 APE8-dihe-in -58.11, 126.83 APE8-rot-na 332.95 APE67-dihe-in -66.85, -7.34 -61.56, -42.87 APE12-dist-na 15.3363 APE11-dist-na 10.6921 APE10-dist-na 7.7435 APE9-dist-in 4.8822 C491A,K659E None None XRAY 2.548 0.202 0.257 A 324.0 282.0 15 30 30 0 [[481, 759]] 1.0 4j97 TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J97B P21802 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.6186 14.1611 BLAminus -137.2, -170.97 56.98, 77.11 -102.2, 28.96 291.71, 89.32 -70.08, -17.2 in-in in 7.4319 Saltbr-in 2.6835 HRD-in -92.02, -43.47 71.93, -10.83 in-in-out SNCiio in-out ActLoopNT-in 2.882 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.22, 28.28 APE9-dihe-in -102.89, 130.04 APE8-dihe-in -52.94, 125.61 APE8-rot-na 331.88 APE67-dihe-in -68.38, -8.99 -59.09, -43.64 APE12-dist-na 15.3327 APE11-dist-na 10.6375 APE10-dist-na 7.7777 APE9-dist-in 4.8875 C491A,K659E None None XRAY 2.548 0.202 0.257 B 324.0 283.0 14 30 30 0 [[481, 759]] 1.0 4j97 TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J97C P21802 467 764 821.0 ACP:801 ATPlike Inactive DFGin 6.6453 13.9457 BLAminus -135.48, -176.12 59.98, 78.76 -103.0, 29.61 294.18, 85.28 -73.23, -9.75 in-in in 7.3695 Saltbr-in 2.7717 HRD-in -84.13, -44.14 69.93, -6.04 in-in-out SNCiio in-out ActLoopNT-in 2.8366 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.47, 19.13 APE9-dihe-in -91.95, 123.86 APE8-dihe-in -53.96, 120.55 APE8-rot-na 330.23 APE67-dihe-in -67.12, -15.11 -56.46, -44.57 APE12-dist-na 15.2845 APE11-dist-na 10.8279 APE10-dist-na 7.6387 APE9-dist-in 4.8499 C491A,K659E None None XRAY 2.548 0.202 0.257 C 324.0 283.0 15 30 30 0 [[481, 759]] 1.0 4j97 TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J97D P21802 466 764 821.0 ACP:801 ATPlike Inactive DFGin 6.5998 13.9519 BLAminus -140.55, -174.15 59.58, 71.6 -94.76, 28.97 293.72, 82.5 -71.76, -12.96 in-in in 7.3264 Saltbr-in 3.2878 HRD-in -86.64, -45.82 71.0, -4.65 in-in-out SNCiio in-out ActLoopNT-in 2.9764 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.43, 15.17 APE9-dihe-in -92.91, 126.7 APE8-dihe-in -55.77, 123.75 APE8-rot-na 332.18 APE67-dihe-in -67.8, -5.5 -58.98, -44.55 APE12-dist-na 15.1752 APE11-dist-na 10.8096 APE10-dist-na 7.6532 APE9-dist-in 4.7736 C491A,K659E None None XRAY 2.548 0.202 0.257 D 324.0 285.0 14 30 30 0 [[481, 759]] 1.0 4j97 TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZPA P21802 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.3482 14.1881 BLAminus -137.17, -165.33 46.36, 75.76 -87.8, 26.94 288.76, 75.56 -66.87, -3.87 in-in in 7.4116 Saltbr-in 2.6456 HRD-in -73.32, -51.09 75.46, -8.12 in-in-out SNCiio in-out ActLoopNT-in 2.8498 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.47, 19.17 APE9-dihe-in -100.03, 131.76 APE8-dihe-in -52.44, 119.43 APE8-rot-na 323.26 APE67-dihe-in -75.98, -2.12 -50.98, -36.8 APE12-dist-na 10.0343 APE11-dist-na 10.8448 APE10-dist-na 7.4564 APE9-dist-in 4.8355 C491A,K526E None None XRAY 2.4 0.214 0.251 A 324.0 280.0 19 30 30 0 [[481, 759]] 1.0 2pzp TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZPB P21802 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.4129 14.3516 BLAminus -140.32, -168.12 49.24, 73.06 -87.89, 30.48 288.51, 77.76 -65.07, -14.98 in-in in 7.4791 Saltbr-in 2.5876 HRD-in -76.07, -43.76 66.74, -12.17 in-in-out SNCiio in-out ActLoopNT-in 2.9313 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.0, 26.29 APE9-dihe-in -103.21, 127.34 APE8-dihe-in -50.89, 117.65 APE8-rot-na 324.07 APE67-dihe-in -70.61, -2.41 -52.07, -42.82 APE12-dist-na 10.1407 APE11-dist-na 10.8019 APE10-dist-na 7.4508 APE9-dist-in 4.9638 C491A,K526E None None XRAY 2.4 0.214 0.251 B 324.0 282.0 17 30 30 0 [[481, 759]] 1.0 2pzp TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZRA P21802 468 765 821.0 ACP:803 ATPlike Inactive DFGin 6.5281 14.0867 BLAminus -124.48, -173.68 60.99, 80.27 -100.69, 20.88 290.45, 81.11 -57.12, -25.75 in-in in 7.4182 Saltbr-in 2.6479 HRD-in -69.22, -43.88 65.36, -10.35 in-in-out SNCiio in-out ActLoopNT-in 2.8333 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -123.95, 17.65 APE9-dihe-in -96.03, 130.55 APE8-dihe-in -55.73, 111.71 APE8-rot-na 326.73 APE67-dihe-in -57.11, -22.38 -39.78, -52.21 APE12-dist-na 9.9733 APE11-dist-na 10.692 APE10-dist-na 7.3862 APE9-dist-in 4.7337 C491A,K641R None None XRAY 3.0 0.201 0.268 A 324.0 280.0 18 30 30 0 [[481, 759]] 1.0 2pzr TYR_FGFR2_HUMAN TYR 8.4e-104 352.4 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZRB P21802 467 766 821.0 ACP:803 ATPlike Inactive DFGin 6.4464 14.1347 BLAminus -124.12, -169.42 57.57, 72.92 -93.39, 13.68 295.44, 82.57 -53.73, -21.74 in-in in 7.6343 Saltbr-in 2.7058 HRD-in -69.55, -51.19 76.09, -22.69 in-in-out SNCiio in-out ActLoopNT-in 2.9447 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.28, 13.02 APE9-dihe-in -94.85, 132.36 APE8-dihe-in -55.27, 118.14 APE8-rot-na 326.76 APE67-dihe-in -72.22, 2.52 -57.29, -38.32 APE12-dist-na 9.9488 APE11-dist-na 10.9786 APE10-dist-na 7.5192 APE9-dist-in 5.0157 C491A,K641R None None XRAY 3.0 0.201 0.268 B 324.0 282.0 18 30 30 0 [[481, 759]] 1.0 2pzr TYR_FGFR2_HUMAN TYR 8.4e-104 352.4 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UHNA P21802 469 764 821.0 ACP:802 ATPlike Inactive DFGin 6.5167 14.0937 BLAminus -136.8, -167.33 56.16, 78.56 -101.45, 21.6 294.96, 102.9 -64.06, -30.14 in-in in 7.8238 Saltbr-in 2.5229 HRD-in -81.24, -42.19 65.24, 0.64 in-in-out SNCiio in-out ActLoopNT-in 2.9627 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -130.72, 22.85 APE9-dihe-in -103.03, 139.99 APE8-dihe-in -59.98, 123.73 APE8-rot-na 335.04 APE67-dihe-in -66.52, -14.98 -63.65, -42.1 APE12-dist-na 14.8547 APE11-dist-na 10.9032 APE10-dist-na 7.5865 APE9-dist-in 4.8843 N549H,E565A None None XRAY 2.909 0.26 0.311 A 324.0 282.0 14 30 30 0 [[481, 759]] 1.0 5uhn TYR_FGFR2_HUMAN TYR 3.3e-103 350.5 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UHNB P21802 469 764 821.0 ACP:802 ATPlike Inactive DFGin 6.5134 14.0231 BLAminus -136.33, -166.28 57.28, 77.94 -101.83, 20.57 295.09, 103.12 -64.81, -29.84 in-in in 7.6634 Saltbr-in 2.4643 HRD-in -80.51, -42.21 65.56, -0.07 in-in-out SNCiio in-out ActLoopNT-in 3.1826 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -129.68, 22.67 APE9-dihe-in -103.05, 139.67 APE8-dihe-in -60.5, 125.01 APE8-rot-na 334.93 APE67-dihe-in -66.52, -14.36 -63.18, -41.76 APE12-dist-na 999.0 APE11-dist-na 10.8143 APE10-dist-na 7.5915 APE9-dist-in 4.8168 N549H,E565A None None XRAY 2.909 0.26 0.311 B 324.0 269.0 27 30 19 11 [[481, 759]] 1.0 5uhn TYR_FGFR2_HUMAN TYR 3.3e-103 350.5 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UGXA P21802 468 764 821.0 ACP:803 ATPlike Inactive DFGin 6.6569 14.0485 BLAminus -131.13, -166.11 46.79, 87.05 -100.0, 21.89 288.47, 85.57 -64.83, -24.6 in-in in 7.6085 Saltbr-in 2.9922 HRD-in -78.16, -51.21 73.9, -1.28 in-in-out SNCiio in-out ActLoopNT-in 2.8666 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.33, 9.75 APE9-dihe-in -97.42, 138.88 APE8-dihe-in -59.74, 121.4 APE8-rot-na 334.26 APE67-dihe-in -70.7, -5.46 -65.5, -39.78 APE12-dist-na 15.029 APE11-dist-na 11.1765 APE10-dist-na 7.4581 APE9-dist-in 4.8037 C491A,E565A None None XRAY 2.349 0.22 0.275 A 324.0 297.0 0 30 30 0 [[481, 759]] 1.0 5ugx TYR_FGFR2_HUMAN TYR 4.5e-103 350.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UGXB P21802 468 764 821.0 ACP:803 ATPlike Inactive DFGin 6.7107 13.9229 BLAminus -132.31, -170.71 52.3, 81.71 -96.0, 22.25 292.25, 87.7 -65.69, -25.27 in-in in 7.3927 Saltbr-in 3.1538 HRD-in -75.61, -53.17 73.28, -1.77 in-in-out SNCiio in-out ActLoopNT-in 2.9195 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.49, 16.52 APE9-dihe-in -100.17, 138.41 APE8-dihe-in -61.9, 122.99 APE8-rot-na 336.36 APE67-dihe-in -71.64, -5.56 -62.65, -38.67 APE12-dist-na 10.081 APE11-dist-na 10.7661 APE10-dist-na 7.2815 APE9-dist-in 4.828 C491A,E565A None None XRAY 2.349 0.22 0.275 B 324.0 282.0 15 30 20 10 [[481, 759]] 1.0 5ugx TYR_FGFR2_HUMAN TYR 4.5e-103 350.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UI0B P21802 462 765 821.0 ACP:802 ATPlike Inactive DFGin 6.5418 14.2132 BLAminus -136.98, -171.82 50.02, 76.91 -91.39, 21.0 284.06, 84.3 -70.34, -15.26 in-in in 7.2433 Saltbr-in 2.9593 HRD-in -80.63, -49.98 74.74, -10.37 in-in-out SNCiio in-out ActLoopNT-in 2.9367 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.5, 32.27 APE9-dihe-in -102.72, 128.27 APE8-dihe-in -51.42, 123.86 APE8-rot-na 328.96 APE67-dihe-in -69.39, -7.95 -60.08, -38.03 APE12-dist-na 14.7842 APE11-dist-na 10.1664 APE10-dist-na 7.6055 APE9-dist-in 4.8551 C491A,E565A None None XRAY 2.05 0.183 0.207 B 324.0 304.0 0 30 30 0 [[481, 759]] 1.0 5ui0 TYR_FGFR2_HUMAN TYR 2.9e-103 350.6 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2Q0BA P21802 468 765 821.0 ACP:803 ATPlike Inactive DFGin 6.5379 14.2376 BLAminus -137.67, -164.26 54.31, 72.63 -95.24, 25.26 285.39, 75.18 -61.23, -29.58 in-in in 7.2432 Saltbr-in 2.7231 HRD-in -79.58, -49.69 74.6, -12.22 in-in-out SNCiio in-out ActLoopNT-in 2.9755 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -123.18, 17.09 APE9-dihe-in -97.34, 129.87 APE8-dihe-in -55.33, 120.72 APE8-rot-na 329.23 APE67-dihe-in -73.97, -8.32 -57.44, -31.43 APE12-dist-na 9.9772 APE11-dist-na 10.659 APE10-dist-na 7.3691 APE9-dist-in 4.751 C491A,E565A None None XRAY 2.9 0.202 0.252 A 324.0 280.0 18 30 30 0 [[481, 759]] 1.0 2q0b TYR_FGFR2_HUMAN TYR 2.1e-103 351.1 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2Q0BB P21802 468 766 821.0 ACP:803 ATPlike Inactive DFGin 6.5637 14.0804 BLAminus -133.38, -173.77 65.46, 65.65 -91.7, 18.1 296.71, 72.83 -55.14, -29.53 in-in in 7.5166 Saltbr-in 2.7361 HRD-in -79.58, -50.53 70.04, -4.81 in-in-out SNCiio in-out ActLoopNT-in 2.7934 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.91, 21.68 APE9-dihe-in -99.61, 129.39 APE8-dihe-in -57.39, 112.59 APE8-rot-na 331.0 APE67-dihe-in -63.49, -9.98 -54.36, -36.94 APE12-dist-na 10.2471 APE11-dist-na 10.8391 APE10-dist-na 7.4917 APE9-dist-in 4.9059 C491A,E565A None None XRAY 2.9 0.202 0.252 B 324.0 282.0 17 30 30 0 [[481, 759]] 1.0 2q0b TYR_FGFR2_HUMAN TYR 2.1e-103 351.1 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PY3A P21802 468 766 821.0 ACP:805 ATPlike Inactive DFGin 6.3947 14.1248 BLAminus -132.09, -167.28 46.92, 77.9 -89.52, 28.18 287.97, 74.42 -64.92, -12.84 in-in in 7.2777 Saltbr-in 2.6425 HRD-in -69.15, -50.28 73.37, -7.92 in-in-out SNCiio in-out ActLoopNT-in 2.9371 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.57, 22.43 APE9-dihe-in -99.04, 131.25 APE8-dihe-in -52.37, 122.48 APE8-rot-na 325.05 APE67-dihe-in -72.14, -6.33 -51.92, -40.9 APE12-dist-na 9.9501 APE11-dist-na 10.6713 APE10-dist-na 7.3862 APE9-dist-in 4.7437 C491A,E565G None None XRAY 2.3 0.217 0.252 A 324.0 282.0 17 30 30 0 [[481, 759]] 1.0 2py3 TYR_FGFR2_HUMAN TYR 2.7e-103 350.7 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PY3B P21802 468 766 821.0 ACP:805 ATPlike Inactive DFGin 6.5146 14.301 BLAminus -135.62, -170.09 51.9, 73.7 -89.2, 28.31 287.78, 75.56 -66.05, -13.03 in-in in 7.4251 Saltbr-in 2.7042 HRD-in -75.46, -47.46 71.33, -10.27 in-in-out SNCiio in-out ActLoopNT-in 2.8572 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.61, 23.33 APE9-dihe-in -100.25, 127.63 APE8-dihe-in -52.55, 116.2 APE8-rot-na 325.69 APE67-dihe-in -68.53, -13.02 -47.88, -42.42 APE12-dist-na 10.0658 APE11-dist-na 10.7884 APE10-dist-na 7.4188 APE9-dist-in 4.9315 C491A,E565G None None XRAY 2.3 0.217 0.252 B 324.0 284.0 15 30 30 0 [[481, 759]] 1.0 2py3 TYR_FGFR2_HUMAN TYR 2.7e-103 350.7 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5EG3A P21802 466 774 821.0 ACP:60801 ATPlike Active DFGin 6.0341 13.8253 BLAminus -138.71, -166.61 47.53, 87.44 -100.17, 28.73 285.85, 82.29 -77.8, -14.99 in-in in 8.0454 Saltbr-in 2.9413 HRD-in -83.82, -45.21 62.18, 9.75 in-in-in SNCiii in-in ActLoopNT-in 2.9913 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.56, 121.06 APE9-dihe-in -128.9, 119.34 APE8-dihe-in -79.6, 67.11 APE8-rot-na 30.51 APE67-dihe-in -77.81, 0.08 -48.0, -39.27 APE12-dist-na 13.5581 APE11-dist-na 10.0782 APE10-dist-na 8.2587 APE9-dist-in 7.0206 Y466F,C491A,E565A,Y586L,Y588P,Y656F,Y657F,K659E PTR769 PTR769 XRAY 2.606 0.191 0.237 A 334.0 302.0 7 30 30 0 [[481, 759]] 1.0 5eg3 TYR_FGFR2_HUMAN TYR 2.3e-101 344.4 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 6V6QA P21802 466 765 821.0 ACP:901 ATPlike Inactive DFGin 6.8945 13.9075 BLAminus -137.26, -178.98 59.51, 71.9 -86.77, 13.5 292.04, 83.56 -59.04, -31.29 in-in in 7.2461 Saltbr-in 3.2891 HRD-in -72.64, -45.97 77.04, -16.81 in-in-out SNCiio in-out ActLoopNT-in 2.9278 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.45, 33.95 APE9-dihe-in -111.95, 129.79 APE8-dihe-in -53.65, 121.81 APE8-rot-na 327.05 APE67-dihe-in -70.56, -11.31 -58.83, -38.12 APE12-dist-na 14.2635 APE11-dist-na 10.4899 APE10-dist-na 7.7703 APE9-dist-in 5.206 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 A 411.0 286.0 14 30 30 0 [[481, 759]] 1.0 6v6q TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 6V6QB P21802 467 766 821.0 ACP:901 ATPlike Inactive DFGin 6.8092 14.1253 BLAminus -136.61, -177.61 60.52, 69.31 -88.63, 15.47 290.7, 96.84 -63.12, -28.34 in-in in 7.3426 Saltbr-in 3.2951 HRD-in -73.07, -46.4 74.87, -14.44 in-in-out SNCiio in-out ActLoopNT-in 2.9198 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.84, 37.71 APE9-dihe-in -109.58, 130.31 APE8-dihe-in -50.87, 122.1 APE8-rot-na 324.14 APE67-dihe-in -69.97, -12.27 -61.49, -37.1 APE12-dist-na 14.1352 APE11-dist-na 10.5874 APE10-dist-na 8.0645 APE9-dist-in 5.1521 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 B 411.0 291.0 9 30 30 0 [[481, 759]] 1.0 6v6q TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 6V6QD P21802 467 765 821.0 ACP:901 ATPlike Inactive DFGin 6.9358 13.9889 BLAminus -136.56, -179.05 59.21, 72.83 -88.1, 16.16 292.51, 97.85 -58.15, -33.51 in-in in 7.3798 Saltbr-in 3.3337 HRD-in -71.81, -47.08 75.08, -13.84 in-in-out SNCiio in-out ActLoopNT-in 2.9416 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.25, 35.34 APE9-dihe-in -111.85, 128.58 APE8-dihe-in -53.13, 121.4 APE8-rot-na 327.69 APE67-dihe-in -69.26, -12.5 -60.26, -36.04 APE12-dist-na 999.0 APE11-dist-na 10.1403 APE10-dist-na 7.4327 APE9-dist-in 5.1119 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 D 411.0 276.0 23 30 21 9 [[481, 759]] 1.0 6v6q TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 6V6QC P21802 467 766 821.0 ACP:901 ATPlike Inactive DFGin 6.7663 13.6427 BLBminus -136.89, -177.89 59.28, 74.24 -85.91, -161.66 300.29, 95.93 81.23, -12.62 in-in in 7.4635 Saltbr-in 3.3138 HRD-in -72.01, -47.4 74.74, -13.46 in-in-out SNCiio in-out ActLoopNT-in 2.9412 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.47, 28.67 APE9-dihe-in -111.04, 128.94 APE8-dihe-in -52.92, 121.96 APE8-rot-na 327.46 APE67-dihe-in -69.24, -12.82 -58.84, -37.31 APE12-dist-na 999.0 APE11-dist-na 10.4975 APE10-dist-na 7.4308 APE9-dist-in 5.0885 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 C 411.0 279.0 21 30 19 11 [[481, 759]] 1.0 6v6q TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR3 FGFR3_HUMAN 4K33A P22607 459 755 806.0 ACP:801 ATPlike Active DFGin 6.2519 13.787 BLAminus -133.88, -173.58 58.49, 82.81 -96.43, 27.55 291.81, 80.95 -59.32, -31.32 in-in in 8.2114 Saltbr-in 2.895 HRD-in -87.09, -47.34 67.06, 1.63 in-in-in SNCiii in-in ActLoopNT-in 2.9905 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.89, 133.11 APE9-dihe-in -125.43, 130.21 APE8-dihe-in -78.76, 72.58 APE8-rot-na 29.71 APE67-dihe-in -71.45, -4.47 -50.14, -48.75 APE12-dist-na 13.3098 APE11-dist-na 9.6016 APE10-dist-na 8.3051 APE9-dist-in 6.8731 C482A,C582S,K650E None None XRAY 2.341 0.181 0.228 A 325.0 293.0 4 30 30 0 [[472, 750]] 1.0 4k33 TYR_FGFR3_HUMAN TYR 2.3e-104 354.2 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 6PNXA P22607 456 757 806.0 ACP:801 ATPlike Inactive DFGin 5.1832 13.2568 BLAplus -117.43, 165.96 59.53, 36.21 -90.35, -22.61 56.49, 88.29 -100.71, 20.75 in-out in 7.758 Saltbr-out 3.8922 HRD-in -72.74, -43.96 72.66, -12.59 out-out-out SNCooo out-out ActLoopNT-out 8.6112 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 61.32, -168.18 APE9-dihe-in -95.45, 138.6 APE8-dihe-in -83.08, 62.92 APE8-rot-na 32.84 APE67-dihe-in -77.59, -4.01 -63.19, -31.79 APE12-dist-na 17.76 APE11-dist-na 14.3869 APE10-dist-na 16.4747 APE9-dist-in 7.9796 C482A,C582S,R669E None None XRAY 2.199 0.195 0.23 A 324.0 291.0 11 30 30 0 [[472, 750]] 1.0 6pnx TYR_FGFR3_HUMAN TYR 2.5e-104 354.1 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 6PNXB P22607 455 756 806.0 ACP:801 ATPlike Inactive DFGin 5.1024 12.8796 BLAplus -116.22, 163.18 57.59, 45.48 -96.33, -11.84 56.51, 88.18 -107.89, 22.55 in-in in 7.3718 Saltbr-in 2.3809 HRD-in -94.02, -38.66 69.29, -17.12 in-out-out SNCioo out-out ActLoopNT-out 4.1485 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 54.33, 74.29 APE9-dihe-in -157.39, 146.53 APE8-dihe-in -79.85, 92.16 APE8-rot-na 29.38 APE67-dihe-in -64.97, -14.94 -62.55, -40.44 APE12-dist-na 17.5294 APE11-dist-na 16.9582 APE10-dist-na 14.6317 APE9-dist-in 7.491 C482A,C582S,R669E None None XRAY 2.199 0.195 0.23 B 324.0 294.0 8 30 30 0 [[472, 750]] 1.0 6pnx TYR_FGFR3_HUMAN TYR 2.5e-104 354.1 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR IGF1R IGF1R_HUMAN 1K3AA P08069 988 1286 1367.0 ACP:60300 ATPlike Inactive DFGin 6.3257 14.2125 ABAminus -128.41, -4.91 -126.86, 131.72 -125.9, 30.62 307.04, 99.18 -55.79, -30.44 in-out in 9.005 Saltbr-out 4.7628 HRD-in -68.21, -48.33 72.95, -10.46 out-in-in SNCoii in-in ActLoopNT-in 2.9218 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.81, 106.37 APE9-dihe-in -118.2, 152.14 APE8-dihe-in -73.75, 68.45 APE8-rot-na 35.41 APE67-dihe-in -73.37, -1.85 -44.97, -44.15 APE12-dist-na 15.1788 APE11-dist-na 11.1053 APE10-dist-na 10.8438 APE9-dist-in 7.1286 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.1 0.212 0.251 A 299.0 291.0 8 30 30 0 [[999, 1268]] 1.0 1k3a TYR_IGF1R_HUMAN TYR 3.1e-95 324.3 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR INSR INSR_HUMAN 4XLVA P06213 1001 1310 1382.0 ACP:61301 ATPlike Active DFGin 6.3572 13.4037 BLAminus -129.47, -169.61 59.33, 81.3 -99.86, 10.75 301.2, 100.62 -50.37, -35.15 in-in in 8.1751 Saltbr-in 2.4413 HRD-in -74.09, -41.95 72.32, -7.69 in-in-in SNCiii in-in ActLoopNT-in 3.0293 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -31.8, 98.01 APE9-dihe-in -128.43, 131.43 APE8-dihe-in -62.62, 111.75 APE8-rot-na 18.22 APE67-dihe-in -71.49, -19.39 -64.21, -23.54 APE12-dist-na 14.7406 APE11-dist-na 10.5509 APE10-dist-na 11.0271 APE9-dist-in 6.6146 Y992F,C1008S PTR999,PTR1185,PTR1189,PTR1190 PTR999,PTR1185,PTR1189,PTR1190 XRAY 2.3 0.207 0.266 A 328.0 310.0 0 30 30 0 [[1023, 1292]] 1.0 4xlv TYR_INSR_HUMAN TYR 1.7e-96 328.5 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR INSR INSR_HUMAN 1I44A P06213 1013 1310 1382.0 ACP:60300 ATPlike Inactive DFGin 6.6413 13.7197 None -58.16, -57.88 -145.23, -170.38 -78.54, 6.88 58.45, 76.71 123.48, 176.59 in-out in 9.122 Saltbr-out 5.8952 HRD-in -61.91, -52.97 77.04, -9.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -75.06 APE8-dihe-out -68.29, 48.19 APE8-rot-na 34.45 APE67-dihe-in -67.23, -7.11 -39.74, -51.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6829 C1008S,Y1011F,D1188A None None XRAY 2.4 0.21 0.268 A 306.0 282.0 16 30 14 16 [[1023, 1292]] 1.0 1i44 TYR_INSR_HUMAN TYR 3.4e-96 327.5 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR TNK2 ACK1_HUMAN 1U54A Q07912 115 390 1038.0 ACP:101 ATPlike Inactive DFGin 6.3812 13.4263 ABAminus -129.39, -12.11 -146.47, 102.96 -102.84, 23.33 304.65, 105.91 -57.05, -37.37 in-in in 7.8643 Saltbr-in 2.6244 HRD-in -77.15, -49.8 83.51, -10.59 in-in-none SNCiin in-none ActLoopNT-in 2.8347 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.54 APE8-dihe-in -75.47, 123.76 APE8-rot-na 349.96 APE67-dihe-in -43.9, -19.78 -62.08, -52.54 APE12-dist-na 11.8082 APE11-dist-na 8.1412 APE10-dist-na 999.0 APE9-dist-in 6.0632 None PTR284 PTR284 XRAY 2.8 0.226 0.322 A 291.0 263.0 13 31 30 1 [[126, 387]] 1.0 1u54 TYR_TNK2_HUMAN TYR 9e-86 293.3 1.0 259.0 259.0 269 270 271 273 275 158 177 181 249 251 250 252.0 312 300 295 294 293 292 291 290 289 206 Activated CDC42 kinase 1
TYR TNK2 ACK1_HUMAN 1U54B Q07912 117 388 1038.0 ACP:400 ATPlike Active DFGin 6.6155 13.3776 BLAminus -120.4, -155.16 27.84, 85.75 -104.36, 38.7 310.01, 93.15 -67.71, -28.73 in-in in 7.966 Saltbr-in 3.0206 HRD-in -109.84, -42.56 64.6, 13.11 in-in-in SNCiii in-in ActLoopNT-in 3.0144 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -150.8, 133.1 APE9-dihe-in -126.86, 129.0 APE8-dihe-in -43.1, 130.27 APE8-rot-na 329.12 APE67-dihe-in -70.13, -6.6 -62.78, -39.45 APE12-dist-na 12.6617 APE11-dist-na 7.6459 APE10-dist-na 10.9998 APE9-dist-in 5.8775 None None None XRAY 2.8 0.226 0.322 B 291.0 261.0 11 31 31 0 [[126, 387]] 1.0 1u54 TYR_TNK2_HUMAN TYR 9e-86 293.3 1.0 259.0 259.0 269 270 271 273 275 158 177 181 249 251 250 252.0 312 300 295 294 293 292 291 290 289 206 Activated CDC42 kinase 1

Ligand: ACP

Total number of chains: 99
Active chains: 11
Total number of genes: 23
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 68 68.7% 4F0FA
DFGin BLBplus 10 10.1% 4ANBA
DFGin ABAminus 6 6.1% 6EQ9A
DFGin BLBminus 5 5.1% 7KJCA
DFGin None 3 3.0% 4C3PA
None None 3 3.0% 6I2PA
DFGin BLAplus 2 2.0% 6PNXB
DFGinter None 2 2.0% 4C3RA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL ROCO4 ROCO4_DICDI 4F0FA Q6XHB2 1019 1292 1726.0 ACP:61301 ATPlike Inactive DFGin 6.9498 15.9628 BLAminus -130.66, 172.28 62.24, 70.89 -92.37, 29.04 286.11, 76.52 -66.1, -24.87 in-in in 8.4554 Saltbr-in 2.5726 HRD-in -73.46, -44.25 65.79, 5.9 in-in-out SNCiio in-out ActLoopNT-in 2.5989 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -114.23, 137.57 APE9-dihe-na -90.18, -37.76 APE8-dihe-in -70.88, 120.21 APE8-rot-na 222.83 APE67-dihe-in -78.4, -5.47 -115.68, -26.3 APE12-dist-in 10.1797 APE11-dist-in 12.5114 APE10-dist-out 9.2223 APE9-dist-out 8.2996 None None None XRAY 1.8 0.198 0.245 A 287.0 274.0 0 25 25 0 [[1026, 1291]] 1.0 4f0f Dictyostelium discoideum TKL_ROCO4_DICDI TKL 3.2e-59 206.6 2.0 266.0 265.0 1176 1177 1178 1180 1182 1055 1078 1082 1151 1153 1152 1154.0 1215 1201 1196 1195 1194 1193 1192 1191 1190 1106 Probable serine/threonine-protein kinase roco4
TKL ROCO4 ROCO4_DICDI 4F1OA Q6XHB2 1019 1292 1726.0 ACP:61301 ATPlike Inactive DFGin 7.1098 15.5425 BLAminus -139.35, 175.97 61.59, 71.39 -91.48, 35.72 286.47, 73.49 -70.25, -38.98 in-in in 8.0862 Saltbr-in 2.782 HRD-in -70.19, -38.92 67.65, -6.5 in-in-out SNCiio in-out ActLoopNT-in 2.7019 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -99.87, 151.06 APE9-dihe-na -83.99, -54.56 APE8-dihe-in -77.41, 78.95 APE8-rot-na 217.99 APE67-dihe-in -67.17, -15.56 -63.92, -29.08 APE12-dist-in 10.3481 APE11-dist-in 12.8064 APE10-dist-out 9.0723 APE9-dist-out 8.1398 None None None XRAY 2.3 0.252 0.296 A 287.0 274.0 0 25 25 0 [[1026, 1291]] 1.0 4f1o Dictyostelium discoideum TKL_ROCO4_DICDI TKL 1.1e-58 204.8 2.0 266.0 265.0 1176 1177 1178 1180 1182 1055 1078 1082 1151 1153 1152 1154.0 1215 1201 1196 1195 1194 1193 1192 1191 1190 1106 Probable serine/threonine-protein kinase roco4
TKL ROCO4 ROCO4_DICDI 4F1MA Q6XHB2 1019 1292 1726.0 ACP:61301,BTB:61302 ATPlike,Allosteric Inactive DFGin 6.7343 15.3101 BLAminus -135.93, 167.45 61.64, 76.62 -97.37, 30.41 286.17, 86.15 -92.2, 166.07 in-in in 8.1479 Saltbr-in 2.8434 HRD-in -65.4, -53.97 73.14, 3.41 in-in-out SNCiio in-out ActLoopNT-in 2.7042 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -114.68, 138.58 APE9-dihe-na -71.39, -65.99 APE8-dihe-in -65.85, 83.01 APE8-rot-na 289.29 APE67-dihe-in -75.86, -13.39 -67.18, -17.16 APE12-dist-in 10.0156 APE11-dist-in 11.7768 APE10-dist-out 8.6781 APE9-dist-out 7.7914 G1179S None None XRAY 2.04 0.263 0.294 A 287.0 274.0 0 25 25 0 [[1026, 1291]] 1.0 4f1m Dictyostelium discoideum TKL_ROCO4_DICDI TKL 3.2e-58 203.3 2.0 266.0 265.0 1176 1177 1178 1180 1182 1055 1078 1082 1151 1153 1152 1154.0 1215 1201 1196 1195 1194 1193 1192 1191 1190 1106 Probable serine/threonine-protein kinase roco4
AGC PRKCI KPCI_HUMAN 5LI9A P41743 248 589 596.0 ACP:60601 ATPlike Active DFGin 5.6347 12.6326 BLAminus -139.17, 172.4 72.31, 78.11 -98.86, 1.23 304.03, 143.26 -64.9, -22.84 in-in in 8.3605 Saltbr-in 2.6142 HRD-in -73.79, -55.22 70.11, -1.11 in-in-in SNCiii in-in ActLoopNT-in 2.8096 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.64, 169.55 APE9-dihe-na 127.72, -178.47 APE8-dihe-in -93.25, 127.56 APE8-rot-in 298.81 APE67-dihe-in -60.64, -20.02 -47.28, -45.36 APE12-dist-in 8.8117 APE11-dist-in 11.9487 APE10-dist-in 6.4318 APE9-dist-in 3.8358 None TPO412,TPO564 TPO412,TPO564 XRAY 1.79 0.19 0.231 A 350.0 330.0 12 28 28 0 [[254, 522]] 1.0 5li9 Homo sapiens AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC RPS6KA1-1 KS6A1_HUMAN 2Z7QA Q15418 56 340 735.0 ACP:500 ATPlike Inactive DFGin 8.0284 12.3687 BLBplus -135.49, 158.95 63.12, 60.24 -125.42, -165.59 47.01, 74.46 107.04, -8.15 none-none none 999.0 Saltbr-none 999.0 HRD-out -82.53, 70.19 -54.28, -43.87 none-out-out SNCnoo out-out ActLoopNT-out 7.0527 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -165.36 APE8-dihe-in -67.18, 106.47 APE8-rot-in 305.06 APE67-dihe-in -59.78, -23.27 -56.13, -39.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.7913 None None None XRAY 2.0 0.264 0.283 A 321.0 255.0 30 28 16 12 [[62, 321], [418, 675]] 2.0 2z7q Homo sapiens AGC_RPS6KA1-1_HUMAN AGC 1.5e-95 325.1 1.0 260.0 260.0 204 205 206 208 210 94 112 116 184 186 185 187.0 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
CAMK AURKA AURKA_HUMAN 4C3PD O14965 125 390 403.0 ACP:1391 ATPlike Inactive DFGin 5.0797 15.0907 ABAminus -119.78, -23.96 -110.92, 146.31 -144.29, 22.56 288.75, 97.88 -63.46, -34.21 out-out out 11.1639 Saltbr-out 5.9729 HRD-out -75.78, -41.12 71.55, -101.13 out-in-out SNCoio in-out ActLoopNT-in 3.1113 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -140.51, -146.18 APE9-dihe-na 83.68, 6.59 APE8-dihe-out -140.3, 13.24 APE8-rot-out 207.12 APE67-dihe-in -44.87, -30.51 -70.19, -27.98 APE12-dist-none 999.0 APE11-dist-out 20.8704 APE10-dist-out 24.1292 APE9-dist-out 28.582 None None None XRAY 2.69 0.205 0.289 D 282.0 260.0 6 26 20 6 [[133, 383]] 1.0 4c3p Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5G15A O14965 126 390 403.0 ACP:1391 ATPlike Inactive DFGin 5.983 16.3862 BLAminus -138.69, -169.03 59.87, 67.73 -86.51, 18.94 284.94, 72.05 -48.14, -38.59 out-out out 10.2958 Saltbr-out 5.1725 HRD-in -73.28, -52.04 69.95, 14.4 out-in-in SNCoii in-in ActLoopNT-in 2.9265 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.64, 165.4 APE9-dihe-na 125.58, -148.7 APE8-dihe-in -133.46, 135.34 APE8-rot-in 292.83 APE67-dihe-in -71.67, -13.58 -36.11, -59.51 APE12-dist-in 10.3189 APE11-dist-in 11.1833 APE10-dist-in 5.6098 APE9-dist-in 3.4626 None None None XRAY 2.06 0.229 0.274 A 282.0 265.0 0 26 26 0 [[133, 383]] 1.0 5g15 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6CPFA O14965 128 392 403.0 ACP:501 ATPlike Inactive DFGin 5.8515 16.0756 BLAminus -125.44, -173.01 51.86, 75.65 -92.36, 20.23 261.59, 77.98 -63.75, -18.06 out-none out 11.2478 Saltbr-none 999.0 HRD-in -104.84, -51.34 76.83, -36.49 none-in-out SNCnio in-out ActLoopNT-in 3.2019 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -168.9 APE8-dihe-in -78.28, 136.09 APE8-rot-out 59.9 APE67-dihe-in -54.01, -29.69 -75.21, 5.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7077 None None None XRAY 2.3 0.222 0.259 A 285.0 259.0 6 26 20 6 [[133, 383]] 1.0 6cpf Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4C3PA O14965 125 388 403.0 ACP:1389 ATPlike Inactive DFGin 5.1209 15.3112 None -143.16, 44.14 -117.33, -72.7 63.16, 22.36 309.54, 103.5 -71.05, -27.42 out-out out 10.7129 Saltbr-out 4.9547 HRD-out -79.39, 150.41 -121.39, -68.05 out-in-out SNCoio in-out ActLoopNT-in 2.8189 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -49.34, 122.38 APE9-dihe-na 116.03, -35.9 APE8-dihe-out -100.65, -0.54 APE8-rot-out 177.69 APE67-dihe-in -57.5, -32.82 -45.19, -41.29 APE12-dist-out 20.9276 APE11-dist-out 21.1759 APE10-dist-out 26.1561 APE9-dist-out 28.5914 None None None XRAY 2.69 0.205 0.289 A 282.0 264.0 0 26 26 0 [[133, 383]] 1.0 4c3p Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4C3RA O14965 127 388 403.0 ACP:1389 ATPlike Inactive DFGinter 6.0871 8.639 None -114.31, -7.36 -87.64, 130.6 -72.8, -47.16 285.43, 29.08 69.28, 138.63 out-out out 11.9632 Saltbr-out 7.7849 HRD-out -148.79, 112.09 -68.12, -80.01 out-out-out SNCooo out-out ActLoopNT-out 8.0165 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 137.49 APE8-dihe-in -74.84, 138.8 APE8-rot-out 199.32 APE67-dihe-in -50.64, -36.72 -89.13, -8.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.2314 None None None XRAY 2.79 0.229 0.306 A 282.0 252.0 10 26 16 10 [[133, 383]] 1.0 4c3r Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6C83B O14965 127 388 403.0 ACP:501 ATPlike Inactive DFGinter 7.3169 8.5877 None -129.69, 90.85 -100.04, 101.37 -135.34, 999.0 303.1, 99.49 999.0, 999.0 out-out out 12.1149 Saltbr-out 10.0494 HRD-out -96.09, 116.19 -110.78, 111.97 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -90.23 APE8-dihe-out -77.58, -0.58 APE8-rot-out 85.03 APE67-dihe-in -69.49, -5.14 -61.84, -44.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.4721 None None None XRAY 2.55 0.268 0.322 B 285.0 247.0 15 26 11 15 [[133, 383]] 1.0 6c83 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6C83A O14965 127 389 403.0 ACP:501 ATPlike Inactive None 999.0 999.0 None -115.58, 146.0 -134.74, 164.64 -155.95, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.2939 Saltbr-none 999.0 HRD-out 57.31, 86.65 -118.52, 133.44 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -76.52 APE8-dihe-out -81.29, 5.34 APE8-rot-out 166.86 APE67-dihe-in -68.45, -16.44 -75.67, -23.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.2563 None None None XRAY 2.55 0.268 0.322 A 285.0 248.0 15 26 11 15 [[133, 383]] 1.0 6c83 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK DAPK1 DAPK1_HUMAN 3ZXTB P53355 7 276 1430.0 ACP:1279 ATPlike None DFGin 6.5753 14.0674 BLAminus -121.46, -170.78 56.12, 80.76 -103.93, 17.27 282.46, 79.2 -56.39, -19.56 in-in in 8.6799 Saltbr-in 2.544 HRD-in -82.72, -41.2 65.14, 3.07 in-in-none SNCiin in-none ActLoopNT-in 2.9485 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -71.62 APE8-rot-none 999.0 APE67-dihe-in -62.85, -24.88 -49.25, -41.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 B 285.0 253.0 17 27 17 10 [[13, 275]] 1.0 3zxt Homo sapiens CAMK_DAPK1_HUMAN CAMK 5.5e-95 323.5 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3ZXTC P53355 5 276 1430.0 ACP:1278 ATPlike None DFGin 6.7644 14.238 BLAminus -125.03, -178.44 64.54, 79.35 -91.9, 24.57 287.83, 76.0 -66.08, -19.72 in-in in 9.3921 Saltbr-in 2.7185 HRD-in -72.23, -37.44 57.47, 4.52 in-in-none SNCiin in-none ActLoopNT-in 3.0967 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -39.65, -42.12 999.0, -61.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 C 285.0 259.0 13 27 16 11 [[13, 275]] 1.0 3zxt Homo sapiens CAMK_DAPK1_HUMAN CAMK 5.5e-95 323.5 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3ZXTD P53355 7 276 1430.0 ACP:1277 ATPlike None DFGin 6.8657 14.6449 BLAminus -115.85, 173.32 73.06, 78.3 -92.76, 17.5 283.87, 68.26 -68.46, 25.44 in-in in 9.3064 Saltbr-in 2.6506 HRD-in -83.16, -46.35 65.92, 13.4 in-in-none SNCiin in-none ActLoopNT-in 3.1078 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -20.61 APE8-rot-none 999.0 APE67-dihe-in -90.53, -15.22 -91.11, -7.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 D 285.0 245.0 25 27 17 10 [[13, 275]] 1.0 3zxt Homo sapiens CAMK_DAPK1_HUMAN CAMK 5.5e-95 323.5 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3ZXTA P53355 7 276 1430.0 ACP:1277 ATPlike Inactive DFGin 6.5391 14.0575 BLBminus -116.48, -174.8 63.15, 89.03 -105.65, -162.71 284.37, 74.81 49.59, 38.57 in-in in 8.9136 Saltbr-in 3.2081 HRD-in -74.82, -48.06 69.59, 6.45 in-in-none SNCiin in-none ActLoopNT-in 2.7248 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -35.07 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 A 285.0 249.0 21 27 15 12 [[13, 275]] 1.0 3zxt Homo sapiens CAMK_DAPK1_HUMAN CAMK 5.5e-95 323.5 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CK1 CSNK1D KC1D_HUMAN 6RU6A P48730 3 294 415.0 ACP:60301 ATPlike Active DFGin 6.4361 15.2637 BLAminus -136.56, 176.84 69.53, 73.53 -93.66, 24.95 289.84, 81.36 -61.77, -30.96 in-in in 7.9234 Saltbr-in 2.7889 HRD-in -77.83, -55.12 76.08, 12.52 in-in-in SNCiii in-in ActLoopNT-in 2.8503 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.64, 119.59 APE9-dihe-na 102.6, -136.74 APE8-dihe-in -117.46, 127.27 APE8-rot-in 311.09 APE67-dihe-in -57.82, -37.85 -53.66, -47.41 APE12-dist-in 12.3149 APE11-dist-in 11.9084 APE10-dist-in 6.4806 APE9-dist-in 3.5052 None None None XRAY 2.05 0.213 0.257 A 296.0 288.0 4 35 35 0 [[9, 275]] 1.0 6ru6 Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU6B P48730 3 294 415.0 ACP:60301 ATPlike None DFGin 6.5901 15.1558 BLAminus -129.63, 177.25 73.9, 71.28 -92.31, 21.27 283.76, 74.29 -58.84, -31.38 in-in in 7.8176 Saltbr-in 2.7964 HRD-in -76.32, -55.32 74.02, 14.82 in-in-none SNCiin in-none ActLoopNT-in 2.8603 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -126.17 APE8-dihe-in -104.51, 127.76 APE8-rot-in 311.88 APE67-dihe-in -57.59, -35.09 -58.93, -44.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.9414 None None None XRAY 2.05 0.213 0.257 B 296.0 278.0 14 35 27 8 [[9, 275]] 1.0 6ru6 Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CMGC CSNK2A1 CSK21_HUMAN 4NH1A P68400 3 332 391.0 ACP:403 ATPlike Inactive DFGin 7.5389 16.0514 BLAminus -114.39, -169.88 57.86, 83.41 -112.16, 31.33 299.65, 85.49 -75.44, -39.86 in-in in 9.2778 Saltbr-in 2.773 HRD-in -89.66, -46.45 59.34, 26.3 in-in-out SNCiio in-out ActLoopNT-in 2.9028 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.56, 170.73 APE9-dihe-na 63.23, 162.58 APE8-dihe-in -68.16, 150.73 APE8-rot-out 180.05 APE67-dihe-in -73.61, -11.12 -57.46, -41.94 APE12-dist-in 12.7146 APE11-dist-in 10.5288 APE10-dist-in 6.0584 APE9-dist-in 3.3234 None None None XRAY 3.3 0.215 0.251 A 335.0 330.0 0 27 27 0 [[39, 324]] 1.0 4nh1 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 4NH1B P68400 2 333 391.0 ACP:404 ATPlike Inactive DFGin 7.5341 16.0013 BLAminus -114.45, -169.84 57.84, 82.99 -112.41, 30.84 300.31, 85.61 -75.38, -39.92 in-in in 9.2314 Saltbr-in 2.7742 HRD-in -90.12, -46.63 59.22, 26.59 in-in-out SNCiio in-out ActLoopNT-in 2.9537 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -120.21, 170.34 APE9-dihe-na 63.1, 162.47 APE8-dihe-in -68.11, 151.28 APE8-rot-out 180.18 APE67-dihe-in -73.01, -10.91 -57.19, -42.14 APE12-dist-in 12.652 APE11-dist-in 10.5276 APE10-dist-in 5.9918 APE9-dist-in 3.3647 None None None XRAY 3.3 0.215 0.251 B 335.0 332.0 0 27 27 0 [[39, 324]] 1.0 4nh1 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC MAPK1 MK01_HUMAN 5V60A P28482 10 358 360.0 ACP:401 ATPlike Active DFGin 6.6686 14.8874 BLAminus -124.21, -175.27 60.56, 75.29 -91.11, 25.45 286.11, 68.09 -67.4, -23.76 in-in in 9.2691 Saltbr-in 3.0882 HRD-in -75.88, -52.24 69.24, 12.32 in-in-in SNCiii in-in ActLoopNT-in 2.9513 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -89.66, 171.23 APE9-dihe-na 66.7, 168.41 APE8-dihe-in -89.68, 141.19 APE8-rot-in 301.48 APE67-dihe-in -66.12, -19.67 -43.41, -50.15 APE12-dist-in 12.5737 APE11-dist-in 11.0864 APE10-dist-in 6.6326 APE9-dist-in 2.9874 None TPO185,PTR187 TPO185,PTR187 XRAY 2.18 0.193 0.226 A 356.0 349.0 0 31 31 0 [[25, 313]] 1.0 5v60 Homo sapiens CMGC_MAPK1_HUMAN CMGC 8.8e-86 293.8 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK10 MK10_HUMAN 6EQ9B P53779 47 400 464.0 ACP:502 ATPlike Inactive DFGin 3.8485 14.5358 ABAminus -85.08, -18.98 -157.51, 177.19 -105.91, 17.98 303.5, 84.3 71.4, -149.1 in-in in 9.644 Saltbr-in 2.8818 HRD-in -75.97, -57.51 71.23, 0.13 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 107.58 APE8-dihe-in -64.66, 120.8 APE8-rot-in 307.67 APE67-dihe-in -65.89, -19.34 -114.84, 1.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0426 None None None XRAY 1.83 0.207 0.252 B 367.0 332.0 14 27 13 14 [[64, 359]] 1.0 6eq9 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 6EQ9A P53779 46 400 464.0 ACP:505,C15:506 ATPlike,Allosteric Inactive DFGin 3.763 14.1786 ABAminus -90.84, -25.71 -146.46, -174.02 -119.81, 8.04 305.39, 99.67 64.39, -162.69 in-out in 9.6534 Saltbr-out 3.9166 HRD-in -74.99, -56.85 72.96, -15.02 out-out-out SNCooo out-out ActLoopNT-out 6.2848 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -45.37 APE8-dihe-in -112.64, 106.03 APE8-rot-in 290.72 APE67-dihe-in -70.8, -9.5 -110.9, 2.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.5168 None None None XRAY 1.83 0.207 0.252 A 367.0 350.0 5 27 22 5 [[64, 359]] 1.0 6eq9 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 8VTFA P53779 45 400 464.0 A1ACP:1101 Type1 Inactive DFGin 4.1231 14.4365 ABAminus -80.88, -55.79 -105.49, 178.52 -116.12, 4.6 292.24, 108.11 97.34, -165.3 out-out out 10.1768 Saltbr-out 6.0587 HRD-in -81.08, -68.87 73.64, -1.6 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -88.73, 154.5 APE9-dihe-na -85.68, 161.75 APE8-dihe-in -104.45, 122.83 APE8-rot-in 288.76 APE67-dihe-in -66.26, -13.42 -118.39, 6.09 APE12-dist-out 21.2043 APE11-dist-out 17.1276 APE10-dist-out 16.3671 APE9-dist-out 11.6243 None None None XRAY 2.4 0.258 0.297 A 464.0 346.0 5 27 22 5 [[64, 359]] 1.0 8vtf Homo sapiens CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
OTHER RNASEL RN5A_HUMAN 4OAVB Q05823 24 717 741.0 ACP:801 ATPlike Pseudo DFGin 6.4754 12.3669 BLAminus -139.92, -178.5 65.74, 91.26 -114.98, 14.68 309.18, 101.1 -77.21, 3.69 in-in in 6.9053 Saltbr-in 2.7395 HRD-in -87.38, -45.25 69.13, -2.14 in-in-na SNCiia in-na ActLoopNT-in 3.0597 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.56, 102.63 APE9-dihe-na -56.52, -19.13 APE8-dihe-na -66.25, -31.04 APE8-rot-na 198.81 APE67-dihe-na -66.21, -44.37 -71.69, -39.0 APE12-dist-na 15.2929 APE11-dist-na 17.0118 APE10-dist-na 15.0202 APE9-dist-na 14.3961 H672N None None XRAY 2.1 0.2 0.229 B 699.0 673.0 8 20 20 0 [[353, 594]] 1.0 4oav Homo sapiens OTHER_RNASEL_HUMAN RNASEL 4.1e-136 459.9 1.0 242.0 242.0 502 503 504 506 508 392 404 408 482 484 483 485.0 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
OTHER RNASEL RN5A_HUMAN 4OAVD Q05823 26 719 741.0 ACP:1001 ATPlike Pseudo DFGin 6.5588 12.4049 BLAminus -138.71, -178.08 64.72, 95.25 -118.8, 14.99 306.98, 96.56 -77.32, 4.45 in-in in 6.904 Saltbr-in 2.919 HRD-in -73.82, -49.38 73.22, -2.68 in-in-na SNCiia in-na ActLoopNT-in 2.9151 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.59, 112.49 APE9-dihe-na -62.01, -29.18 APE8-dihe-na -62.89, -32.55 APE8-rot-na 188.49 APE67-dihe-na -70.07, -38.9 -67.42, -39.34 APE12-dist-na 14.651 APE11-dist-na 16.869 APE10-dist-na 14.6353 APE9-dist-na 14.3519 H672N None None XRAY 2.1 0.2 0.229 D 699.0 674.0 7 20 20 0 [[353, 594]] 1.0 4oav Homo sapiens OTHER_RNASEL_HUMAN RNASEL 4.1e-136 459.9 1.0 242.0 242.0 502 503 504 506 508 392 404 408 482 484 483 485.0 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
STE MAP2K1 MP2K1_HUMAN 6U2GA Q02750 43 383 393.0 ACP:901 ATPlike Inactive DFGin 5.8079 13.8406 BLBplus -143.7, 174.8 53.7, 47.78 -98.62, 156.52 46.78, 97.62 -76.59, 70.13 out-out out 15.3736 Saltbr-out 14.8686 HRD-in -83.28, -55.76 76.37, -10.26 out-out-out SNCooo out-out ActLoopNT-out 9.207 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -64.24, 146.48 APE9-dihe-na -101.23, -173.03 APE8-dihe-out -114.34, -9.62 APE8-rot-out 55.71 APE67-dihe-out -148.86, 141.69 -149.81, 176.75 APE12-dist-out 19.1865 APE11-dist-out 17.9815 APE10-dist-out 22.1053 APE9-dist-out 12.9996 None None None XRAY 2.886 0.231 0.276 A 394.0 309.0 32 26 26 0 [[68, 361]] 1.0 6u2g Homo sapiens STE_MAP2K1_HUMAN STE 2.4e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNEA Q02750 63 379 393.0 ACP:901,573:903 ATPlike,Type1 Inactive DFGin 6.3821 13.6901 BLBplus -140.61, 176.72 54.72, 28.13 -81.46, 161.59 52.56, 86.0 -81.78, 73.09 out-out out 15.4969 Saltbr-out 15.7793 HRD-in -64.01, -56.53 90.31, -35.13 out-out-out SNCooo out-out ActLoopNT-out 9.2902 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -73.66, 137.78 APE9-dihe-na -84.79, 178.97 APE8-dihe-out -113.02, -24.38 APE8-rot-out 49.94 APE67-dihe-out -153.46, 146.56 -142.39, -172.52 APE12-dist-out 17.192 APE11-dist-out 21.6533 APE10-dist-out 23.7976 APE9-dist-out 13.4974 None None None XRAY 2.848 0.186 0.24 A 341.0 286.0 31 26 26 0 [[68, 361]] 1.0 4mne Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNED Q02750 66 382 393.0 ACP:901,573:903 ATPlike,Type1 Inactive DFGin 6.2631 13.8726 BLBplus -124.78, 174.1 56.33, 33.25 -88.39, 154.28 50.46, 89.74 -73.02, 74.09 out-out out 15.5381 Saltbr-out 15.6141 HRD-in -64.9, -49.38 74.62, -12.51 out-out-out SNCooo out-out ActLoopNT-out 9.0432 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -65.65, 150.79 APE9-dihe-na -95.28, -163.25 APE8-dihe-out -122.75, -11.87 APE8-rot-out 68.42 APE67-dihe-out -159.06, 142.59 -161.08, -176.92 APE12-dist-out 17.403 APE11-dist-out 21.784 APE10-dist-out 23.8522 APE9-dist-out 13.6322 None None None XRAY 2.848 0.186 0.24 D 341.0 285.0 32 26 26 0 [[68, 361]] 1.0 4mne Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4AN9A Q02750 61 381 393.0 ACP:61382,2P7:61384 ATPlike,Type3 Inactive DFGin 6.3107 13.7515 BLBplus -147.68, 174.84 72.25, 33.73 -84.91, 163.57 42.25, 107.87 -96.68, 81.85 out-out out 15.6879 Saltbr-out 15.1088 HRD-in -67.38, -51.77 90.36, -23.63 out-out-out SNCooo out-out ActLoopNT-out 9.4167 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_onoo APE10-dihe-na 999.0, 140.8 APE9-dihe-na -91.12, -166.68 APE8-dihe-in -63.03, 65.46 APE8-rot-in 350.49 APE67-dihe-in -61.1, -23.55 -42.53, -42.27 APE12-dist-out 17.6262 APE11-dist-none 999.0 APE10-dist-out 19.7035 APE9-dist-out 7.8575 S218E,S222E,G328A None None XRAY 2.8 0.205 0.313 A 301.0 278.0 1 26 25 1 [[68, 361]] 1.0 4an9 Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNEE Q02750 62 379 393.0 ACP:901,573:903 ATPlike,Type3 Inactive DFGin 6.3012 13.7407 BLBplus -139.17, 176.14 61.58, 40.21 -96.23, 153.1 47.97, 96.35 -69.87, 64.71 out-out out 15.7956 Saltbr-out 16.1573 HRD-in -84.17, -39.22 69.48, -27.4 out-out-out SNCooo out-out ActLoopNT-out 9.2771 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -76.04, 124.0 APE9-dihe-na -78.04, -178.79 APE8-dihe-out -111.0, -36.1 APE8-rot-out 69.56 APE67-dihe-out -140.43, 146.63 -132.48, 167.21 APE12-dist-out 17.6629 APE11-dist-out 21.7751 APE10-dist-out 24.2369 APE9-dist-out 13.5531 None None None XRAY 2.848 0.186 0.24 E 341.0 286.0 32 26 26 0 [[68, 361]] 1.0 4mne Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNEH Q02750 66 380 393.0 ACP:901,573:903,573:904 ATPlike,Type3,Allosteric Inactive DFGin 6.3776 13.8909 BLBplus -149.03, 175.24 52.75, 36.33 -93.4, 157.98 53.98, 84.28 -78.54, 56.84 out-out out 15.8147 Saltbr-out 15.4559 HRD-in -72.48, -51.28 80.05, -1.12 out-out-out SNCooo out-out ActLoopNT-out 9.1113 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -63.87, 146.83 APE9-dihe-na -98.86, 164.39 APE8-dihe-out -71.61, -59.39 APE8-rot-in 294.12 APE67-dihe-out -156.42, 156.79 -128.0, -169.25 APE12-dist-out 17.7474 APE11-dist-out 21.8877 APE10-dist-out 24.1565 APE9-dist-out 13.6645 None None None XRAY 2.848 0.186 0.24 H 341.0 275.0 40 26 26 0 [[68, 361]] 1.0 4mne Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4AN2A Q02750 61 381 393.0 EUI:61382,ACP:61383 Type3,ATPlike Inactive DFGin 6.5059 13.6203 BLBplus -122.79, 178.99 56.84, 40.15 -92.39, 167.6 39.23, 93.66 -89.21, 72.99 out-out out 15.4473 Saltbr-out 15.2762 HRD-in -67.56, -54.42 79.08, -11.1 out-out-out SNCooo out-out ActLoopNT-out 9.0354 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -98.27, 63.09 APE9-dihe-na -45.72, -71.67 APE8-dihe-in -89.8, 67.42 APE8-rot-out 5.41 APE67-dihe-in -66.45, -14.82 -49.39, -42.64 APE12-dist-out 17.4744 APE11-dist-out 16.5588 APE10-dist-out 17.0301 APE9-dist-out 8.7163 S218E,S222E,G328A None None XRAY 2.5 0.215 0.299 A 301.0 279.0 0 26 26 0 [[68, 361]] 1.0 4an2 Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4ANBA Q02750 61 381 393.0 YQY:60501,ACP:60502 Type3,ATPlike Inactive DFGin 6.3584 13.3927 BLBplus -107.54, 172.13 64.32, 39.17 -93.81, 160.33 38.34, 94.07 -83.38, 74.0 out-out out 15.2238 Saltbr-out 14.8172 HRD-in -75.33, -47.65 77.84, -16.31 out-out-out SNCooo out-out ActLoopNT-out 9.4144 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -89.14, -39.83 APE9-dihe-na 89.67, -158.68 APE8-dihe-in -87.88, 72.09 APE8-rot-out 15.75 APE67-dihe-in -64.72, -18.82 -69.34, -22.58 APE12-dist-out 17.552 APE11-dist-out 16.8932 APE10-dist-out 19.8413 APE9-dist-out 8.65 S218E,S222E,G328A None None XRAY 2.2 0.23 0.296 A 301.0 279.0 0 26 26 0 [[68, 361]] 1.0 4anb Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
TKL BRAF BRAF_HUMAN 6U2GB P15056 451 722 766.0 ACP:901 ATPlike Inactive DFGin 6.1502 13.9094 BLBplus -127.14, -173.09 46.65, 53.2 -113.93, 152.92 52.73, 94.7 72.25, -152.99 out-out out 14.6056 Saltbr-out 12.7046 HRD-in -59.19, -53.53 76.48, -9.73 out-out-out SNCooo out-out ActLoopNT-out 9.495 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -146.07, 161.59 APE9-dihe-na 90.18, -141.72 APE8-dihe-in -101.38, 139.04 APE8-rot-out 180.97 APE67-dihe-in -60.58, -31.67 -70.85, -22.56 APE12-dist-out 15.3356 APE11-dist-out 15.7094 APE10-dist-out 13.5919 APE9-dist-out 9.8922 None None None XRAY 2.886 0.231 0.276 B 307.0 264.0 8 30 22 8 [[457, 716]] 1.0 6u2g Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL RIPK2 RIPK2_HUMAN 5NG0A O43353 6 300 540.0 ACP:1000 ATPlike Inactive DFGin 5.8784 14.1777 BLAminus -123.27, -179.27 62.78, 77.58 -93.4, 20.77 286.94, 75.81 -61.85, -28.6 in-in in 8.2049 Saltbr-in 2.7453 HRD-in -73.28, -52.62 66.02, 10.49 in-in-out SNCiio in-out ActLoopNT-in 2.8467 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 157.46 APE8-dihe-in -72.18, 143.02 APE8-rot-out 185.7 APE67-dihe-in -65.61, -24.81 -104.28, 1.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8005 L294F None None XRAY 2.0 0.171 0.191 A 304.0 274.0 21 33 18 15 [[18, 292]] 1.0 5ng0 Homo sapiens TKL_RIPK2_HUMAN TKL 4.1e-73 252.1 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5NG0B O43353 5 299 540.0 ACP:401 ATPlike Inactive DFGin 5.8866 14.1774 BLAminus -123.03, -178.96 62.29, 77.78 -94.31, 21.44 286.41, 77.58 -63.12, -27.82 in-in in 8.1596 Saltbr-in 2.756 HRD-in -74.08, -51.77 69.59, 3.54 in-in-out SNCiio in-out ActLoopNT-in 2.8525 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -72.33, -175.56 APE9-dihe-na 154.16, -172.85 APE8-dihe-in -105.14, 130.27 APE8-rot-in 300.55 APE67-dihe-in -61.64, -28.91 -51.09, -46.77 APE12-dist-in 11.85 APE11-dist-out 7.4022 APE10-dist-in 6.0202 APE9-dist-in 3.3421 L294F None None XRAY 2.0 0.171 0.191 B 304.0 282.0 13 33 23 10 [[18, 292]] 1.0 5ng0 Homo sapiens TKL_RIPK2_HUMAN TKL 4.1e-73 252.1 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5AR3A O43353 6 310 540.0 ACP:1311 ATPlike Inactive DFGin 5.9241 14.2881 BLAminus -133.03, 175.56 72.21, 76.24 -97.68, 34.32 293.9, 86.68 -66.76, -37.47 in-in in 7.9943 Saltbr-in 2.7998 HRD-in -61.0, -40.82 51.84, 8.75 in-in-out SNCiio in-out ActLoopNT-in 2.841 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -117.65 APE9-dihe-na 164.28, -57.84 APE8-dihe-in -114.77, 107.38 APE8-rot-out 185.6 APE67-dihe-in -64.24, -32.65 -95.4, 6.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.7091 APE9-dist-out 10.828 None None None XRAY 3.23 0.192 0.254 A 326.0 279.0 26 33 19 14 [[18, 292]] 1.0 5ar3 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5AR3B O43353 6 310 540.0 ACP:1311 ATPlike Inactive DFGin 5.8705 14.4182 BLAminus -128.31, 176.09 65.92, 78.1 -98.91, 35.33 294.64, 70.55 -68.55, -48.71 in-in in 8.021 Saltbr-in 2.8795 HRD-in -65.19, -46.65 55.58, 8.54 in-in-out SNCiio in-out ActLoopNT-in 2.8614 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.98 APE8-rot-out 49.06 APE67-dihe-in -39.82, -41.25 -97.08, -7.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.23 0.192 0.254 B 326.0 276.0 29 33 17 16 [[18, 292]] 1.0 5ar3 Homo sapiens TKL_RIPK2_HUMAN TKL 5.3e-73 251.8 4.0 266.0 263.0 163 164 165 167 169 47 66 70 143 145 144 146.0 211 196 191 190 189 188 187 186 185 96 Receptor-interacting serine/threonine-protein kinase 2
TYR EPHA2 EPHA2_HUMAN 7KJAB P29317 590 965 976.0 ACP:61003 ATPlike None DFGin 5.9498 15.3185 BLAminus -132.83, -173.32 70.39, 83.56 -118.78, 24.56 302.85, 98.09 -89.22, 999.0 in-in in 8.6069 Saltbr-in 3.1653 HRD-in -76.56, -48.38 78.92, -16.95 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.75 APE8-rot-na 32.08 APE67-dihe-in -69.28, -11.58 -65.6, -29.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.19 0.217 B 390.0 349.0 22 31 11 20 [[613, 873]] 1.0 7kja Homo sapiens TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 7KJCA P29317 590 976 976.0 ACP:61001 ATPlike Inactive DFGin 5.8783 14.9304 BLBminus -137.77, -170.41 70.81, 83.37 -119.58, 163.56 301.23, 100.14 146.26, -161.86 in-in in 8.3547 Saltbr-in 3.0316 HRD-in -75.87, -47.34 76.1, -11.46 in-out-none SNCion out-none ActLoopNT-out 9.6694 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 107.51 APE9-dihe-in -145.96, 148.03 APE8-dihe-in -73.29, 89.61 APE8-rot-na 29.38 APE67-dihe-in -67.75, -13.33 -62.67, -32.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.5466 APE9-dist-in 6.6396 S901E None None XRAY 2.3 0.19 0.226 A 390.0 373.0 8 31 26 5 [[613, 873]] 1.0 7kjc Homo sapiens TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 7KJCB P29317 590 965 976.0 ACP:61002 ATPlike Inactive DFGin 5.9635 15.2035 BLBminus -132.91, -166.6 60.51, 83.21 -117.48, 163.92 299.39, 100.57 145.47, 999.0 in-in in 8.4672 Saltbr-in 3.1302 HRD-in -75.7, -46.49 74.32, -9.38 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 86.32 APE8-rot-na 29.03 APE67-dihe-in -66.96, -12.86 -66.13, -32.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 S901E None None XRAY 2.3 0.19 0.226 B 390.0 347.0 23 31 11 20 [[613, 873]] 1.0 7kjc Homo sapiens TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 7KJAA P29317 590 976 976.0 ACP:61002 ATPlike Inactive DFGin 5.763 14.7694 BLBminus -129.59, -174.19 75.99, 88.0 -122.87, 170.51 304.47, 101.43 99.06, 999.0 in-in in 8.4239 Saltbr-in 3.0553 HRD-in -76.77, -48.29 79.69, -17.22 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.1 APE8-rot-na 32.23 APE67-dihe-in -70.25, -11.59 -65.39, -29.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.19 0.217 A 390.0 361.0 20 31 11 20 [[613, 873]] 1.0 7kja Homo sapiens TYR_EPHA2_HUMAN TYR 1.2e-107 365.1 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR FGFR1 FGFR1_HUMAN 3GQIA P11362 464 770 822.0 ACP:775 ATPlike Active DFGin 6.4659 13.9462 BLAminus -126.61, -175.83 60.19, 72.36 -91.08, 18.42 288.73, 91.63 -64.67, -15.4 in-in in 7.7514 Saltbr-in 2.6904 HRD-in -77.5, -49.87 72.48, -2.68 in-in-in SNCiii in-in ActLoopNT-in 2.9611 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.96, 135.34 APE9-dihe-in -149.19, 136.62 APE8-dihe-in -75.51, 66.48 APE8-rot-na 33.4 APE67-dihe-in -65.08, -11.82 -44.91, -41.18 APE12-dist-na 14.0832 APE11-dist-na 11.2584 APE10-dist-na 10.1277 APE9-dist-in 7.1373 C488A,Y583F,C584S,Y585F PTR653,PTR654,PTR766 PTR653,PTR654,PTR766 XRAY 2.5 0.249 0.289 A 326.0 307.0 0 30 30 0 [[478, 756]] 1.0 3gqi Homo sapiens TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR2 FGFR2_HUMAN 2PWLA P21802 467 764 821.0 ACP:300 ATPlike Inactive DFGin 6.4511 14.1775 BLAminus -131.61, -167.38 56.51, 73.64 -92.98, 26.06 293.6, 74.93 -63.45, -20.7 in-in in 7.5864 Saltbr-in 2.8562 HRD-in -77.4, -49.09 71.28, -7.85 in-in-out SNCiio in-out ActLoopNT-in 2.8847 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.03, 20.75 APE9-dihe-in -94.74, 135.38 APE8-dihe-in -58.69, 123.68 APE8-rot-na 326.81 APE67-dihe-in -69.99, -5.92 -52.74, -45.54 APE12-dist-na 10.002 APE11-dist-na 10.6782 APE10-dist-na 7.4317 APE9-dist-in 4.749 C491A,N549H None None XRAY 2.4 0.21 0.238 A 324.0 284.0 14 30 30 0 [[481, 759]] 1.0 2pwl Homo sapiens TYR_FGFR2_HUMAN TYR 3.1e-104 353.8 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PWLB P21802 468 765 821.0 ACP:300 ATPlike Inactive DFGin 6.4391 14.2798 BLAminus -131.94, -168.62 54.17, 75.02 -93.02, 25.01 292.99, 76.23 -61.28, -25.59 in-in in 7.6919 Saltbr-in 3.0703 HRD-in -69.87, -47.96 69.48, -8.93 in-in-out SNCiio in-out ActLoopNT-in 2.9161 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.23, 16.85 APE9-dihe-in -95.43, 136.0 APE8-dihe-in -55.13, 121.27 APE8-rot-na 324.13 APE67-dihe-in -66.61, -7.86 -55.94, -44.16 APE12-dist-na 10.0887 APE11-dist-na 10.8542 APE10-dist-na 7.4849 APE9-dist-in 4.9122 C491A,N549H None None XRAY 2.4 0.21 0.238 B 324.0 286.0 12 30 30 0 [[481, 759]] 1.0 2pwl Homo sapiens TYR_FGFR2_HUMAN TYR 3.1e-104 353.8 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J96B P21802 462 766 821.0 ACP:803 ATPlike Inactive DFGin 6.422 14.0694 BLAminus -135.07, -171.17 49.96, 77.75 -93.13, 20.28 283.65, 85.2 -66.67, -18.8 in-out in 7.205 Saltbr-out 3.6908 HRD-in -86.85, -47.88 76.0, -13.66 out-in-out SNCoio in-out ActLoopNT-in 2.8113 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.69, 28.85 APE9-dihe-in -99.38, 128.67 APE8-dihe-in -54.56, 125.51 APE8-rot-na 329.88 APE67-dihe-in -70.35, -5.29 -58.48, -39.96 APE12-dist-na 14.7243 APE11-dist-na 10.1541 APE10-dist-na 7.5072 APE9-dist-in 4.9304 C491A,K659M None None XRAY 2.297 0.178 0.219 B 324.0 305.0 0 30 30 0 [[481, 759]] 1.0 4j96 Homo sapiens TYR_FGFR2_HUMAN TYR 2.7e-104 354.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J98B P21802 461 764 821.0 ACP:804 ATPlike Inactive DFGin 6.5497 14.0416 BLAminus -130.09, -172.54 52.51, 78.98 -94.32, 21.96 285.07, 86.18 -63.61, -22.45 in-in in 7.1129 Saltbr-in 3.0165 HRD-in -86.21, -48.16 74.7, -12.01 in-in-out SNCiio in-out ActLoopNT-in 2.8085 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.22, 26.63 APE9-dihe-in -99.48, 124.84 APE8-dihe-in -50.97, 125.51 APE8-rot-na 328.99 APE67-dihe-in -68.16, -7.57 -60.28, -41.11 APE12-dist-na 15.0958 APE11-dist-na 10.4175 APE10-dist-na 7.5796 APE9-dist-in 4.8265 C491A,K659Q None None XRAY 2.307 0.19 0.234 B 324.0 304.0 0 30 30 0 [[481, 759]] 1.0 4j98 Homo sapiens TYR_FGFR2_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVFA P21802 467 765 821.0 ACP:60300 ATPlike Active DFGin 6.0481 13.8212 BLAminus -138.88, -175.17 54.67, 80.46 -90.11, 24.33 291.08, 76.38 -54.38, -36.38 in-in in 7.9134 Saltbr-in 2.7695 HRD-in -85.37, -48.4 70.03, 0.26 in-in-in SNCiii in-in ActLoopNT-in 2.8789 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.94, 115.27 APE9-dihe-in -125.87, 160.91 APE8-dihe-in -74.41, 68.1 APE8-rot-na 35.92 APE67-dihe-in -70.82, -9.54 -47.44, -41.99 APE12-dist-na 15.1398 APE11-dist-na 11.6492 APE10-dist-na 11.6038 APE9-dist-in 7.1679 C491A PTR586,PTR656,PTR657 PTR586,PTR656,PTR657 XRAY 1.8 0.251 0.265 A 334.0 288.0 11 30 30 0 [[481, 759]] 1.0 2pvf Homo sapiens TYR_FGFR2_HUMAN TYR 2.2e-104 354.3 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 3CLYA P21802 468 772 821.0 ACP:61803 ATPlike Active DFGin 6.2295 14.1831 BLAminus -138.78, -172.76 51.4, 79.79 -91.29, 32.46 290.47, 75.81 -61.86, -29.26 in-in in 7.6608 Saltbr-in 2.6208 HRD-in -89.86, -45.92 68.93, -0.84 in-in-in SNCiii in-in ActLoopNT-in 2.8691 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.79, 139.96 APE9-dihe-in -131.36, 152.18 APE8-dihe-in -76.17, 66.16 APE8-rot-na 37.1 APE67-dihe-in -66.78, -6.73 -47.95, -40.48 APE12-dist-na 13.2533 APE11-dist-na 10.4024 APE10-dist-na 11.0968 APE9-dist-in 6.9127 C491A PTR656,PTR657 PTR656,PTR657 XRAY 2.0 0.216 0.247 A 334.0 291.0 14 30 30 0 [[481, 759]] 1.0 3cly Homo sapiens TYR_FGFR2_HUMAN TYR 2.2e-104 354.3 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J99A P21802 466 764 821.0 ACP:802 ATPlike Inactive DFGin 6.7153 14.1397 BLAminus -130.96, -174.69 58.83, 77.45 -92.73, 19.29 291.78, 87.39 -60.03, -34.11 in-in in 7.6098 Saltbr-in 2.8446 HRD-in -78.19, -48.52 73.01, -4.76 in-in-out SNCiio in-out ActLoopNT-in 2.8606 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.36, 29.03 APE9-dihe-in -109.75, 138.54 APE8-dihe-in -57.3, 116.33 APE8-rot-na 330.48 APE67-dihe-in -70.7, -10.42 -57.47, -40.52 APE12-dist-na 15.0402 APE11-dist-na 11.232 APE10-dist-na 7.9723 APE9-dist-in 5.1297 C491A,K659T None None XRAY 1.847 0.206 0.24 A 324.0 280.0 19 30 26 4 [[481, 759]] 1.0 4j99 Homo sapiens TYR_FGFR2_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J99B P21802 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.666 14.1883 BLAminus -133.21, -176.0 58.56, 76.97 -94.04, 15.78 292.83, 99.53 -58.91, -32.83 in-in in 7.584 Saltbr-in 2.6156 HRD-in -76.65, -48.86 73.31, -6.92 in-in-out SNCiio in-out ActLoopNT-in 2.9004 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -118.89, 30.62 APE9-dihe-in -108.84, 137.25 APE8-dihe-in -57.12, 118.19 APE8-rot-na 330.19 APE67-dihe-in -70.1, -10.12 -57.01, -39.76 APE12-dist-na 14.1481 APE11-dist-na 11.074 APE10-dist-na 8.0074 APE9-dist-in 5.1802 C491A,K659T None None XRAY 1.847 0.206 0.24 B 324.0 291.0 7 30 30 0 [[481, 759]] 1.0 4j99 Homo sapiens TYR_FGFR2_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J99C P21802 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.8355 14.168 BLAminus -131.87, -175.54 59.17, 75.71 -91.42, 19.92 291.67, 85.71 -59.92, -32.59 in-in in 7.6282 Saltbr-in 2.9134 HRD-in -76.88, -47.72 74.23, -7.36 in-in-out SNCiio in-out ActLoopNT-in 2.8938 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.66, 30.6 APE9-dihe-in -110.19, 138.06 APE8-dihe-in -55.44, 118.46 APE8-rot-na 330.51 APE67-dihe-in -70.73, -10.29 -57.12, -38.65 APE12-dist-na 14.1212 APE11-dist-na 10.9538 APE10-dist-na 8.0502 APE9-dist-in 5.3615 C491A,K659T None None XRAY 1.847 0.206 0.24 C 324.0 291.0 7 30 30 0 [[481, 759]] 1.0 4j99 Homo sapiens TYR_FGFR2_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J99D P21802 465 764 821.0 ACP:802 ATPlike Inactive DFGin 6.5929 14.159 BLAminus -133.66, -174.57 58.72, 78.56 -92.61, 20.44 290.96, 82.99 -59.4, -33.38 in-in in 7.6313 Saltbr-in 2.6395 HRD-in -78.38, -50.11 73.68, -6.22 in-in-out SNCiio in-out ActLoopNT-in 2.8934 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.76, 31.03 APE9-dihe-in -108.34, 137.61 APE8-dihe-in -55.35, 118.06 APE8-rot-na 330.85 APE67-dihe-in -71.9, -11.56 -55.67, -38.95 APE12-dist-na 999.0 APE11-dist-na 11.135 APE10-dist-na 7.8592 APE9-dist-in 4.9921 C491A,K659T None None XRAY 1.847 0.206 0.24 D 324.0 281.0 19 30 27 3 [[481, 759]] 1.0 4j99 Homo sapiens TYR_FGFR2_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVYA P21802 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.7496 14.2737 BLAminus -142.14, -176.01 63.9, 72.69 -96.2, 30.01 293.76, 86.07 -65.9, -30.73 in-in in 7.5474 Saltbr-in 2.8523 HRD-in -84.99, -48.7 74.29, -16.98 in-in-out SNCiio in-out ActLoopNT-in 2.8094 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.15, 32.71 APE9-dihe-in -103.67, 126.67 APE8-dihe-in -51.63, 122.63 APE8-rot-na 323.69 APE67-dihe-in -64.04, -12.74 -56.98, -40.88 APE12-dist-na 14.8138 APE11-dist-na 10.095 APE10-dist-na 7.5375 APE9-dist-in 4.9554 C491A,K659N None None XRAY 2.2 0.236 0.276 A 324.0 288.0 10 30 30 0 [[481, 759]] 1.0 2pvy Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVYB P21802 462 764 821.0 ACP:8002 ATPlike Inactive DFGin 6.635 14.0654 BLAminus -144.27, -177.95 57.14, 77.78 -93.97, 24.89 293.34, 84.21 -55.49, -34.1 in-in in 7.3161 Saltbr-in 2.8469 HRD-in -81.21, -48.71 71.97, -12.52 in-in-out SNCiio in-out ActLoopNT-in 2.8523 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.68, 30.22 APE9-dihe-in -107.46, 135.49 APE8-dihe-in -57.98, 120.91 APE8-rot-na 329.38 APE67-dihe-in -64.69, -5.42 -51.47, -46.8 APE12-dist-na 999.0 APE11-dist-na 10.6935 APE10-dist-na 7.435 APE9-dist-in 5.0657 C491A,K659N None None XRAY 2.2 0.236 0.276 B 324.0 286.0 17 30 24 6 [[481, 759]] 1.0 2pvy Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVYC P21802 462 764 821.0 ACP:802 ATPlike Inactive DFGin 6.6933 14.018 BLAminus -131.41, -174.32 49.42, 82.58 -94.81, 27.78 293.52, 79.4 -60.72, -24.91 in-in in 7.2286 Saltbr-in 3.5766 HRD-in -81.5, -47.6 72.07, -14.53 in-in-out SNCiio in-out ActLoopNT-in 2.7937 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.89, 24.55 APE9-dihe-in -101.87, 134.03 APE8-dihe-in -55.3, 120.87 APE8-rot-na 330.19 APE67-dihe-in -64.04, -6.89 -51.83, -46.76 APE12-dist-na 14.3155 APE11-dist-na 10.3228 APE10-dist-na 7.4377 APE9-dist-in 5.0687 C491A,K659N None None XRAY 2.2 0.236 0.276 C 324.0 285.0 18 30 25 5 [[481, 759]] 1.0 2pvy Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PVYD P21802 467 764 821.0 ACP:802 ATPlike Inactive DFGin 6.9442 14.2611 BLAminus -139.76, -174.3 61.15, 74.17 -97.41, 31.68 293.81, 79.18 -66.75, -30.92 in-in in 7.2983 Saltbr-in 3.0357 HRD-in -85.65, -49.02 75.46, -18.01 in-in-out SNCiio in-out ActLoopNT-in 2.8112 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.37, 33.11 APE9-dihe-in -102.8, 126.29 APE8-dihe-in -51.84, 123.89 APE8-rot-na 324.49 APE67-dihe-in -63.66, -13.12 -61.69, -37.66 APE12-dist-na 14.8282 APE11-dist-na 10.0923 APE10-dist-na 7.5701 APE9-dist-in 4.9682 C491A,K659N None None XRAY 2.2 0.236 0.276 D 324.0 283.0 15 30 30 0 [[481, 759]] 1.0 2pvy Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J95A P21802 467 764 821.0 ACP:801 ATPlike Inactive DFGin 6.6906 14.0578 BLAminus -131.56, -174.19 63.25, 76.63 -98.25, 22.24 292.31, 85.68 -64.6, -23.3 in-in in 7.7521 Saltbr-in 2.8109 HRD-in -79.93, -52.54 74.87, -4.09 in-in-out SNCiio in-out ActLoopNT-in 2.9917 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.79, 21.67 APE9-dihe-in -99.53, 131.21 APE8-dihe-in -54.93, 120.24 APE8-rot-na 331.68 APE67-dihe-in -73.86, -8.05 -61.39, -39.09 APE12-dist-na 14.7733 APE11-dist-na 10.9527 APE10-dist-na 7.48 APE9-dist-in 4.8674 C491A,K659N None None XRAY 2.377 0.214 0.255 A 324.0 279.0 19 30 26 4 [[481, 759]] 1.0 4j95 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J95B P21802 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.6767 14.3781 BLAminus -131.79, -176.38 62.78, 77.42 -96.59, 21.6 290.19, 86.46 -65.99, -23.31 in-in in 7.797 Saltbr-in 2.9027 HRD-in -80.06, -52.15 74.05, -5.91 in-in-out SNCiio in-out ActLoopNT-in 2.8975 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.95, 20.73 APE9-dihe-in -101.19, 131.88 APE8-dihe-in -53.9, 121.25 APE8-rot-na 331.03 APE67-dihe-in -73.96, -6.54 -59.67, -39.95 APE12-dist-na 14.9774 APE11-dist-na 11.0211 APE10-dist-na 7.7091 APE9-dist-in 4.8559 C491A,K659N None None XRAY 2.377 0.214 0.255 B 324.0 282.0 15 30 30 0 [[481, 759]] 1.0 4j95 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J95C P21802 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.762 14.3167 BLAminus -132.19, -176.54 63.57, 76.14 -98.34, 23.39 290.03, 85.39 -65.87, -22.89 in-in in 7.7358 Saltbr-in 2.8246 HRD-in -79.64, -52.73 75.27, -7.0 in-in-out SNCiio in-out ActLoopNT-in 2.9588 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.5, 23.85 APE9-dihe-in -97.28, 128.27 APE8-dihe-in -54.92, 121.79 APE8-rot-na 330.61 APE67-dihe-in -73.19, -7.42 -60.17, -39.19 APE12-dist-na 14.7321 APE11-dist-na 10.3649 APE10-dist-na 7.4131 APE9-dist-in 4.9058 C491A,K659N None None XRAY 2.377 0.214 0.255 C 324.0 281.0 16 30 30 0 [[481, 759]] 1.0 4j95 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J95D P21802 467 764 821.0 ACP:801 ATPlike Inactive DFGin 6.6005 14.0737 BLAminus -131.84, -175.28 62.91, 77.06 -96.79, 22.82 289.52, 85.1 -64.56, -22.95 in-in in 7.6408 Saltbr-in 2.7469 HRD-in -80.37, -53.3 74.73, -6.2 in-in-out SNCiio in-out ActLoopNT-in 3.0328 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.03, 23.13 APE9-dihe-in -98.93, 130.46 APE8-dihe-in -52.66, 122.62 APE8-rot-na 330.72 APE67-dihe-in -75.07, -8.74 -59.5, -40.3 APE12-dist-na 999.0 APE11-dist-na 10.8037 APE10-dist-na 7.616 APE9-dist-in 4.8025 C491A,K659N None None XRAY 2.377 0.214 0.255 D 324.0 271.0 27 30 19 11 [[481, 759]] 1.0 4j95 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 354.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZ5A P21802 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.2698 14.129 BLAminus -134.55, -165.25 46.14, 76.71 -87.82, 24.61 288.3, 73.06 -57.77, -17.99 in-in in 7.3761 Saltbr-in 2.7198 HRD-in -71.49, -53.18 74.61, -7.33 in-in-out SNCiio in-out ActLoopNT-in 2.9544 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.92, 23.05 APE9-dihe-in -100.29, 130.1 APE8-dihe-in -50.24, 116.35 APE8-rot-na 324.43 APE67-dihe-in -70.43, -5.4 -48.06, -44.87 APE12-dist-na 10.1619 APE11-dist-na 10.8924 APE10-dist-na 7.5553 APE9-dist-in 4.8296 C491A,N549T None None XRAY 2.4 0.214 0.254 A 324.0 280.0 19 30 30 0 [[481, 759]] 1.0 2pz5 Homo sapiens TYR_FGFR2_HUMAN TYR 4.5e-104 353.3 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZ5B P21802 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.4195 14.2227 BLAminus -139.02, -170.4 49.42, 74.35 -88.07, 29.83 289.06, 77.09 -65.84, -12.67 in-in in 7.3045 Saltbr-in 2.7727 HRD-in -68.79, -48.45 71.17, -10.83 in-in-out SNCiio in-out ActLoopNT-in 2.9235 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.66, 23.86 APE9-dihe-in -102.44, 130.7 APE8-dihe-in -54.21, 119.21 APE8-rot-na 323.97 APE67-dihe-in -67.2, -7.87 -53.61, -43.12 APE12-dist-na 10.0458 APE11-dist-na 10.8116 APE10-dist-na 7.3934 APE9-dist-in 4.9807 C491A,N549T None None XRAY 2.4 0.214 0.254 B 324.0 280.0 19 30 30 0 [[481, 759]] 1.0 2pz5 Homo sapiens TYR_FGFR2_HUMAN TYR 4.5e-104 353.3 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J97A P21802 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.5502 14.1232 BLAminus -139.14, -173.61 59.78, 71.54 -95.85, 23.3 290.64, 88.77 -67.56, -16.73 in-in in 7.3156 Saltbr-in 3.0041 HRD-in -83.97, -47.07 72.51, -7.44 in-in-out SNCiio in-out ActLoopNT-in 2.8773 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.39, 21.13 APE9-dihe-in -97.79, 130.15 APE8-dihe-in -58.11, 126.83 APE8-rot-na 332.95 APE67-dihe-in -66.85, -7.34 -61.56, -42.87 APE12-dist-na 15.3363 APE11-dist-na 10.6921 APE10-dist-na 7.7435 APE9-dist-in 4.8822 C491A,K659E None None XRAY 2.548 0.202 0.257 A 324.0 282.0 15 30 30 0 [[481, 759]] 1.0 4j97 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J97B P21802 468 764 821.0 ACP:801 ATPlike Inactive DFGin 6.6186 14.1611 BLAminus -137.2, -170.97 56.98, 77.11 -102.2, 28.96 291.71, 89.32 -70.08, -17.2 in-in in 7.4319 Saltbr-in 2.6835 HRD-in -92.02, -43.47 71.93, -10.83 in-in-out SNCiio in-out ActLoopNT-in 2.882 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.22, 28.28 APE9-dihe-in -102.89, 130.04 APE8-dihe-in -52.94, 125.61 APE8-rot-na 331.88 APE67-dihe-in -68.38, -8.99 -59.09, -43.64 APE12-dist-na 15.3327 APE11-dist-na 10.6375 APE10-dist-na 7.7777 APE9-dist-in 4.8875 C491A,K659E None None XRAY 2.548 0.202 0.257 B 324.0 283.0 14 30 30 0 [[481, 759]] 1.0 4j97 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J97C P21802 467 764 821.0 ACP:801 ATPlike Inactive DFGin 6.6453 13.9457 BLAminus -135.48, -176.12 59.98, 78.76 -103.0, 29.61 294.18, 85.28 -73.23, -9.75 in-in in 7.3695 Saltbr-in 2.7717 HRD-in -84.13, -44.14 69.93, -6.04 in-in-out SNCiio in-out ActLoopNT-in 2.8366 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.47, 19.13 APE9-dihe-in -91.95, 123.86 APE8-dihe-in -53.96, 120.55 APE8-rot-na 330.23 APE67-dihe-in -67.12, -15.11 -56.46, -44.57 APE12-dist-na 15.2845 APE11-dist-na 10.8279 APE10-dist-na 7.6387 APE9-dist-in 4.8499 C491A,K659E None None XRAY 2.548 0.202 0.257 C 324.0 283.0 15 30 30 0 [[481, 759]] 1.0 4j97 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 4J97D P21802 466 764 821.0 ACP:801 ATPlike Inactive DFGin 6.5998 13.9519 BLAminus -140.55, -174.15 59.58, 71.6 -94.76, 28.97 293.72, 82.5 -71.76, -12.96 in-in in 7.3264 Saltbr-in 3.2878 HRD-in -86.64, -45.82 71.0, -4.65 in-in-out SNCiio in-out ActLoopNT-in 2.9764 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.43, 15.17 APE9-dihe-in -92.91, 126.7 APE8-dihe-in -55.77, 123.75 APE8-rot-na 332.18 APE67-dihe-in -67.8, -5.5 -58.98, -44.55 APE12-dist-na 15.1752 APE11-dist-na 10.8096 APE10-dist-na 7.6532 APE9-dist-in 4.7736 C491A,K659E None None XRAY 2.548 0.202 0.257 D 324.0 285.0 14 30 30 0 [[481, 759]] 1.0 4j97 Homo sapiens TYR_FGFR2_HUMAN TYR 2.8e-104 353.9 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZPA P21802 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.3482 14.1881 BLAminus -137.17, -165.33 46.36, 75.76 -87.8, 26.94 288.76, 75.56 -66.87, -3.87 in-in in 7.4116 Saltbr-in 2.6456 HRD-in -73.32, -51.09 75.46, -8.12 in-in-out SNCiio in-out ActLoopNT-in 2.8498 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.47, 19.17 APE9-dihe-in -100.03, 131.76 APE8-dihe-in -52.44, 119.43 APE8-rot-na 323.26 APE67-dihe-in -75.98, -2.12 -50.98, -36.8 APE12-dist-na 10.0343 APE11-dist-na 10.8448 APE10-dist-na 7.4564 APE9-dist-in 4.8355 C491A,K526E None None XRAY 2.4 0.214 0.251 A 324.0 280.0 19 30 30 0 [[481, 759]] 1.0 2pzp Homo sapiens TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZPB P21802 468 766 821.0 ACP:300 ATPlike Inactive DFGin 6.4129 14.3516 BLAminus -140.32, -168.12 49.24, 73.06 -87.89, 30.48 288.51, 77.76 -65.07, -14.98 in-in in 7.4791 Saltbr-in 2.5876 HRD-in -76.07, -43.76 66.74, -12.17 in-in-out SNCiio in-out ActLoopNT-in 2.9313 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.0, 26.29 APE9-dihe-in -103.21, 127.34 APE8-dihe-in -50.89, 117.65 APE8-rot-na 324.07 APE67-dihe-in -70.61, -2.41 -52.07, -42.82 APE12-dist-na 10.1407 APE11-dist-na 10.8019 APE10-dist-na 7.4508 APE9-dist-in 4.9638 C491A,K526E None None XRAY 2.4 0.214 0.251 B 324.0 282.0 17 30 30 0 [[481, 759]] 1.0 2pzp Homo sapiens TYR_FGFR2_HUMAN TYR 2.6e-104 354.1 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZRA P21802 468 765 821.0 ACP:803 ATPlike Inactive DFGin 6.5281 14.0867 BLAminus -124.48, -173.68 60.99, 80.27 -100.69, 20.88 290.45, 81.11 -57.12, -25.75 in-in in 7.4182 Saltbr-in 2.6479 HRD-in -69.22, -43.88 65.36, -10.35 in-in-out SNCiio in-out ActLoopNT-in 2.8333 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -123.95, 17.65 APE9-dihe-in -96.03, 130.55 APE8-dihe-in -55.73, 111.71 APE8-rot-na 326.73 APE67-dihe-in -57.11, -22.38 -39.78, -52.21 APE12-dist-na 9.9733 APE11-dist-na 10.692 APE10-dist-na 7.3862 APE9-dist-in 4.7337 C491A,K641R None None XRAY 3.0 0.201 0.268 A 324.0 280.0 18 30 30 0 [[481, 759]] 1.0 2pzr Homo sapiens TYR_FGFR2_HUMAN TYR 8.4e-104 352.4 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PZRB P21802 467 766 821.0 ACP:803 ATPlike Inactive DFGin 6.4464 14.1347 BLAminus -124.12, -169.42 57.57, 72.92 -93.39, 13.68 295.44, 82.57 -53.73, -21.74 in-in in 7.6343 Saltbr-in 2.7058 HRD-in -69.55, -51.19 76.09, -22.69 in-in-out SNCiio in-out ActLoopNT-in 2.9447 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.28, 13.02 APE9-dihe-in -94.85, 132.36 APE8-dihe-in -55.27, 118.14 APE8-rot-na 326.76 APE67-dihe-in -72.22, 2.52 -57.29, -38.32 APE12-dist-na 9.9488 APE11-dist-na 10.9786 APE10-dist-na 7.5192 APE9-dist-in 5.0157 C491A,K641R None None XRAY 3.0 0.201 0.268 B 324.0 282.0 18 30 30 0 [[481, 759]] 1.0 2pzr Homo sapiens TYR_FGFR2_HUMAN TYR 8.4e-104 352.4 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UHNA P21802 469 764 821.0 ACP:802 ATPlike Inactive DFGin 6.5167 14.0937 BLAminus -136.8, -167.33 56.16, 78.56 -101.45, 21.6 294.96, 102.9 -64.06, -30.14 in-in in 7.8238 Saltbr-in 2.5229 HRD-in -81.24, -42.19 65.24, 0.64 in-in-out SNCiio in-out ActLoopNT-in 2.9627 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -130.72, 22.85 APE9-dihe-in -103.03, 139.99 APE8-dihe-in -59.98, 123.73 APE8-rot-na 335.04 APE67-dihe-in -66.52, -14.98 -63.65, -42.1 APE12-dist-na 14.8547 APE11-dist-na 10.9032 APE10-dist-na 7.5865 APE9-dist-in 4.8843 N549H,E565A None None XRAY 2.909 0.26 0.311 A 324.0 282.0 14 30 30 0 [[481, 759]] 1.0 5uhn Homo sapiens TYR_FGFR2_HUMAN TYR 3.3e-103 350.5 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UHNB P21802 469 764 821.0 ACP:802 ATPlike Inactive DFGin 6.5134 14.0231 BLAminus -136.33, -166.28 57.28, 77.94 -101.83, 20.57 295.09, 103.12 -64.81, -29.84 in-in in 7.6634 Saltbr-in 2.4643 HRD-in -80.51, -42.21 65.56, -0.07 in-in-out SNCiio in-out ActLoopNT-in 3.1826 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -129.68, 22.67 APE9-dihe-in -103.05, 139.67 APE8-dihe-in -60.5, 125.01 APE8-rot-na 334.93 APE67-dihe-in -66.52, -14.36 -63.18, -41.76 APE12-dist-na 999.0 APE11-dist-na 10.8143 APE10-dist-na 7.5915 APE9-dist-in 4.8168 N549H,E565A None None XRAY 2.909 0.26 0.311 B 324.0 269.0 27 30 19 11 [[481, 759]] 1.0 5uhn Homo sapiens TYR_FGFR2_HUMAN TYR 3.3e-103 350.5 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UGXA P21802 468 764 821.0 ACP:803 ATPlike Inactive DFGin 6.6569 14.0485 BLAminus -131.13, -166.11 46.79, 87.05 -100.0, 21.89 288.47, 85.57 -64.83, -24.6 in-in in 7.6085 Saltbr-in 2.9922 HRD-in -78.16, -51.21 73.9, -1.28 in-in-out SNCiio in-out ActLoopNT-in 2.8666 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.33, 9.75 APE9-dihe-in -97.42, 138.88 APE8-dihe-in -59.74, 121.4 APE8-rot-na 334.26 APE67-dihe-in -70.7, -5.46 -65.5, -39.78 APE12-dist-na 15.029 APE11-dist-na 11.1765 APE10-dist-na 7.4581 APE9-dist-in 4.8037 C491A,E565A None None XRAY 2.349 0.22 0.275 A 324.0 297.0 0 30 30 0 [[481, 759]] 1.0 5ugx Homo sapiens TYR_FGFR2_HUMAN TYR 4.5e-103 350.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UGXB P21802 468 764 821.0 ACP:803 ATPlike Inactive DFGin 6.7107 13.9229 BLAminus -132.31, -170.71 52.3, 81.71 -96.0, 22.25 292.25, 87.7 -65.69, -25.27 in-in in 7.3927 Saltbr-in 3.1538 HRD-in -75.61, -53.17 73.28, -1.77 in-in-out SNCiio in-out ActLoopNT-in 2.9195 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.49, 16.52 APE9-dihe-in -100.17, 138.41 APE8-dihe-in -61.9, 122.99 APE8-rot-na 336.36 APE67-dihe-in -71.64, -5.56 -62.65, -38.67 APE12-dist-na 10.081 APE11-dist-na 10.7661 APE10-dist-na 7.2815 APE9-dist-in 4.828 C491A,E565A None None XRAY 2.349 0.22 0.275 B 324.0 282.0 15 30 20 10 [[481, 759]] 1.0 5ugx Homo sapiens TYR_FGFR2_HUMAN TYR 4.5e-103 350.0 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UI0B P21802 462 765 821.0 ACP:802 ATPlike Inactive DFGin 6.5418 14.2132 BLAminus -136.98, -171.82 50.02, 76.91 -91.39, 21.0 284.06, 84.3 -70.34, -15.26 in-in in 7.2433 Saltbr-in 2.9593 HRD-in -80.63, -49.98 74.74, -10.37 in-in-out SNCiio in-out ActLoopNT-in 2.9367 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.5, 32.27 APE9-dihe-in -102.72, 128.27 APE8-dihe-in -51.42, 123.86 APE8-rot-na 328.96 APE67-dihe-in -69.39, -7.95 -60.08, -38.03 APE12-dist-na 14.7842 APE11-dist-na 10.1664 APE10-dist-na 7.6055 APE9-dist-in 4.8551 C491A,E565A None None XRAY 2.05 0.183 0.207 B 324.0 304.0 0 30 30 0 [[481, 759]] 1.0 5ui0 Homo sapiens TYR_FGFR2_HUMAN TYR 2.9e-103 350.6 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2Q0BA P21802 468 765 821.0 ACP:803 ATPlike Inactive DFGin 6.5379 14.2376 BLAminus -137.67, -164.26 54.31, 72.63 -95.24, 25.26 285.39, 75.18 -61.23, -29.58 in-in in 7.2432 Saltbr-in 2.7231 HRD-in -79.58, -49.69 74.6, -12.22 in-in-out SNCiio in-out ActLoopNT-in 2.9755 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -123.18, 17.09 APE9-dihe-in -97.34, 129.87 APE8-dihe-in -55.33, 120.72 APE8-rot-na 329.23 APE67-dihe-in -73.97, -8.32 -57.44, -31.43 APE12-dist-na 9.9772 APE11-dist-na 10.659 APE10-dist-na 7.3691 APE9-dist-in 4.751 C491A,E565A None None XRAY 2.9 0.202 0.252 A 324.0 280.0 18 30 30 0 [[481, 759]] 1.0 2q0b Homo sapiens TYR_FGFR2_HUMAN TYR 2.1e-103 351.1 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2Q0BB P21802 468 766 821.0 ACP:803 ATPlike Inactive DFGin 6.5637 14.0804 BLAminus -133.38, -173.77 65.46, 65.65 -91.7, 18.1 296.71, 72.83 -55.14, -29.53 in-in in 7.5166 Saltbr-in 2.7361 HRD-in -79.58, -50.53 70.04, -4.81 in-in-out SNCiio in-out ActLoopNT-in 2.7934 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.91, 21.68 APE9-dihe-in -99.61, 129.39 APE8-dihe-in -57.39, 112.59 APE8-rot-na 331.0 APE67-dihe-in -63.49, -9.98 -54.36, -36.94 APE12-dist-na 10.2471 APE11-dist-na 10.8391 APE10-dist-na 7.4917 APE9-dist-in 4.9059 C491A,E565A None None XRAY 2.9 0.202 0.252 B 324.0 282.0 17 30 30 0 [[481, 759]] 1.0 2q0b Homo sapiens TYR_FGFR2_HUMAN TYR 2.1e-103 351.1 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PY3A P21802 468 766 821.0 ACP:805 ATPlike Inactive DFGin 6.3947 14.1248 BLAminus -132.09, -167.28 46.92, 77.9 -89.52, 28.18 287.97, 74.42 -64.92, -12.84 in-in in 7.2777 Saltbr-in 2.6425 HRD-in -69.15, -50.28 73.37, -7.92 in-in-out SNCiio in-out ActLoopNT-in 2.9371 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.57, 22.43 APE9-dihe-in -99.04, 131.25 APE8-dihe-in -52.37, 122.48 APE8-rot-na 325.05 APE67-dihe-in -72.14, -6.33 -51.92, -40.9 APE12-dist-na 9.9501 APE11-dist-na 10.6713 APE10-dist-na 7.3862 APE9-dist-in 4.7437 C491A,E565G None None XRAY 2.3 0.217 0.252 A 324.0 282.0 17 30 30 0 [[481, 759]] 1.0 2py3 Homo sapiens TYR_FGFR2_HUMAN TYR 2.7e-103 350.7 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 2PY3B P21802 468 766 821.0 ACP:805 ATPlike Inactive DFGin 6.5146 14.301 BLAminus -135.62, -170.09 51.9, 73.7 -89.2, 28.31 287.78, 75.56 -66.05, -13.03 in-in in 7.4251 Saltbr-in 2.7042 HRD-in -75.46, -47.46 71.33, -10.27 in-in-out SNCiio in-out ActLoopNT-in 2.8572 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.61, 23.33 APE9-dihe-in -100.25, 127.63 APE8-dihe-in -52.55, 116.2 APE8-rot-na 325.69 APE67-dihe-in -68.53, -13.02 -47.88, -42.42 APE12-dist-na 10.0658 APE11-dist-na 10.7884 APE10-dist-na 7.4188 APE9-dist-in 4.9315 C491A,E565G None None XRAY 2.3 0.217 0.252 B 324.0 284.0 15 30 30 0 [[481, 759]] 1.0 2py3 Homo sapiens TYR_FGFR2_HUMAN TYR 2.7e-103 350.7 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5EG3A P21802 466 774 821.0 ACP:60801 ATPlike Active DFGin 6.0341 13.8253 BLAminus -138.71, -166.61 47.53, 87.44 -100.17, 28.73 285.85, 82.29 -77.8, -14.99 in-in in 8.0454 Saltbr-in 2.9413 HRD-in -83.82, -45.21 62.18, 9.75 in-in-in SNCiii in-in ActLoopNT-in 2.9913 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.56, 121.06 APE9-dihe-in -128.9, 119.34 APE8-dihe-in -79.6, 67.11 APE8-rot-na 30.51 APE67-dihe-in -77.81, 0.08 -48.0, -39.27 APE12-dist-na 13.5581 APE11-dist-na 10.0782 APE10-dist-na 8.2587 APE9-dist-in 7.0206 Y466F,C491A,E565A,Y586L,Y588P,Y656F,Y657F,K659E PTR769 PTR769 XRAY 2.606 0.191 0.237 A 334.0 302.0 7 30 30 0 [[481, 759]] 1.0 5eg3 Homo sapiens TYR_FGFR2_HUMAN TYR 2.3e-101 344.4 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 6V6QA P21802 466 765 821.0 ACP:901 ATPlike Inactive DFGin 6.8945 13.9075 BLAminus -137.26, -178.98 59.51, 71.9 -86.77, 13.5 292.04, 83.56 -59.04, -31.29 in-in in 7.2461 Saltbr-in 3.2891 HRD-in -72.64, -45.97 77.04, -16.81 in-in-out SNCiio in-out ActLoopNT-in 2.9278 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.45, 33.95 APE9-dihe-in -111.95, 129.79 APE8-dihe-in -53.65, 121.81 APE8-rot-na 327.05 APE67-dihe-in -70.56, -11.31 -58.83, -38.12 APE12-dist-na 14.2635 APE11-dist-na 10.4899 APE10-dist-na 7.7703 APE9-dist-in 5.206 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 A 411.0 286.0 14 30 30 0 [[481, 759]] 1.0 6v6q Homo sapiens TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 6V6QB P21802 467 766 821.0 ACP:901 ATPlike Inactive DFGin 6.8092 14.1253 BLAminus -136.61, -177.61 60.52, 69.31 -88.63, 15.47 290.7, 96.84 -63.12, -28.34 in-in in 7.3426 Saltbr-in 3.2951 HRD-in -73.07, -46.4 74.87, -14.44 in-in-out SNCiio in-out ActLoopNT-in 2.9198 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.84, 37.71 APE9-dihe-in -109.58, 130.31 APE8-dihe-in -50.87, 122.1 APE8-rot-na 324.14 APE67-dihe-in -69.97, -12.27 -61.49, -37.1 APE12-dist-na 14.1352 APE11-dist-na 10.5874 APE10-dist-na 8.0645 APE9-dist-in 5.1521 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 B 411.0 291.0 9 30 30 0 [[481, 759]] 1.0 6v6q Homo sapiens TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 6V6QD P21802 467 765 821.0 ACP:901 ATPlike Inactive DFGin 6.9358 13.9889 BLAminus -136.56, -179.05 59.21, 72.83 -88.1, 16.16 292.51, 97.85 -58.15, -33.51 in-in in 7.3798 Saltbr-in 3.3337 HRD-in -71.81, -47.08 75.08, -13.84 in-in-out SNCiio in-out ActLoopNT-in 2.9416 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.25, 35.34 APE9-dihe-in -111.85, 128.58 APE8-dihe-in -53.13, 121.4 APE8-rot-na 327.69 APE67-dihe-in -69.26, -12.5 -60.26, -36.04 APE12-dist-na 999.0 APE11-dist-na 10.1403 APE10-dist-na 7.4327 APE9-dist-in 5.1119 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 D 411.0 276.0 23 30 21 9 [[481, 759]] 1.0 6v6q Homo sapiens TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 6V6QC P21802 467 766 821.0 ACP:901 ATPlike Inactive DFGin 6.7663 13.6427 BLBminus -136.89, -177.89 59.28, 74.24 -85.91, -161.66 300.29, 95.93 81.23, -12.62 in-in in 7.4635 Saltbr-in 3.3138 HRD-in -72.01, -47.4 74.74, -13.46 in-in-out SNCiio in-out ActLoopNT-in 2.9412 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.47, 28.67 APE9-dihe-in -111.04, 128.94 APE8-dihe-in -52.92, 121.96 APE8-rot-na 327.46 APE67-dihe-in -69.24, -12.82 -58.84, -37.31 APE12-dist-na 999.0 APE11-dist-na 10.4975 APE10-dist-na 7.4308 APE9-dist-in 5.0885 Y466F,Y561F,Y566F,Y575F,Y586F,Y588F,Y608F,Y616F,Y657F,Y733F PTR656 PTR656 XRAY 2.46 0.213 0.239 C 411.0 279.0 21 30 19 11 [[481, 759]] 1.0 6v6q Homo sapiens TYR_FGFR2_HUMAN TYR 8.7e-101 342.6 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR3 FGFR3_HUMAN 4K33A P22607 459 755 806.0 ACP:801 ATPlike Active DFGin 6.2519 13.787 BLAminus -133.88, -173.58 58.49, 82.81 -96.43, 27.55 291.81, 80.95 -59.32, -31.32 in-in in 8.2114 Saltbr-in 2.895 HRD-in -87.09, -47.34 67.06, 1.63 in-in-in SNCiii in-in ActLoopNT-in 2.9905 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.89, 133.11 APE9-dihe-in -125.43, 130.21 APE8-dihe-in -78.76, 72.58 APE8-rot-na 29.71 APE67-dihe-in -71.45, -4.47 -50.14, -48.75 APE12-dist-na 13.3098 APE11-dist-na 9.6016 APE10-dist-na 8.3051 APE9-dist-in 6.8731 C482A,C582S,K650E None None XRAY 2.341 0.181 0.228 A 325.0 293.0 4 30 30 0 [[472, 750]] 1.0 4k33 Homo sapiens TYR_FGFR3_HUMAN TYR 2.3e-104 354.2 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 6PNXA P22607 456 757 806.0 ACP:801 ATPlike Inactive DFGin 5.1832 13.2568 BLAplus -117.43, 165.96 59.53, 36.21 -90.35, -22.61 56.49, 88.29 -100.71, 20.75 in-out in 7.758 Saltbr-out 3.8922 HRD-in -72.74, -43.96 72.66, -12.59 out-out-out SNCooo out-out ActLoopNT-out 8.6112 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 61.32, -168.18 APE9-dihe-in -95.45, 138.6 APE8-dihe-in -83.08, 62.92 APE8-rot-na 32.84 APE67-dihe-in -77.59, -4.01 -63.19, -31.79 APE12-dist-na 17.76 APE11-dist-na 14.3869 APE10-dist-na 16.4747 APE9-dist-in 7.9796 C482A,C582S,R669E None None XRAY 2.199 0.195 0.23 A 324.0 291.0 11 30 30 0 [[472, 750]] 1.0 6pnx Homo sapiens TYR_FGFR3_HUMAN TYR 2.5e-104 354.1 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 6PNXB P22607 455 756 806.0 ACP:801 ATPlike Inactive DFGin 5.1024 12.8796 BLAplus -116.22, 163.18 57.59, 45.48 -96.33, -11.84 56.51, 88.18 -107.89, 22.55 in-in in 7.3718 Saltbr-in 2.3809 HRD-in -94.02, -38.66 69.29, -17.12 in-out-out SNCioo out-out ActLoopNT-out 4.1485 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 54.33, 74.29 APE9-dihe-in -157.39, 146.53 APE8-dihe-in -79.85, 92.16 APE8-rot-na 29.38 APE67-dihe-in -64.97, -14.94 -62.55, -40.44 APE12-dist-na 17.5294 APE11-dist-na 16.9582 APE10-dist-na 14.6317 APE9-dist-in 7.491 C482A,C582S,R669E None None XRAY 2.199 0.195 0.23 B 324.0 294.0 8 30 30 0 [[472, 750]] 1.0 6pnx Homo sapiens TYR_FGFR3_HUMAN TYR 2.5e-104 354.1 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR IGF1R IGF1R_HUMAN 1K3AA P08069 988 1286 1367.0 ACP:60300 ATPlike Inactive DFGin 6.3257 14.2125 ABAminus -128.41, -4.91 -126.86, 131.72 -125.9, 30.62 307.04, 99.18 -55.79, -30.44 in-out in 9.005 Saltbr-out 4.7628 HRD-in -68.21, -48.33 72.95, -10.46 out-in-in SNCoii in-in ActLoopNT-in 2.9218 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.81, 106.37 APE9-dihe-in -118.2, 152.14 APE8-dihe-in -73.75, 68.45 APE8-rot-na 35.41 APE67-dihe-in -73.37, -1.85 -44.97, -44.15 APE12-dist-na 15.1788 APE11-dist-na 11.1053 APE10-dist-na 10.8438 APE9-dist-in 7.1286 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.1 0.212 0.251 A 299.0 291.0 8 30 30 0 [[999, 1268]] 1.0 1k3a Homo sapiens TYR_IGF1R_HUMAN TYR 3.1e-95 324.3 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR INSR INSR_HUMAN 4XLVA P06213 1001 1310 1382.0 ACP:61301 ATPlike Active DFGin 6.3572 13.4037 BLAminus -129.47, -169.61 59.33, 81.3 -99.86, 10.75 301.2, 100.62 -50.37, -35.15 in-in in 8.1751 Saltbr-in 2.4413 HRD-in -74.09, -41.95 72.32, -7.69 in-in-in SNCiii in-in ActLoopNT-in 3.0293 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -31.8, 98.01 APE9-dihe-in -128.43, 131.43 APE8-dihe-in -62.62, 111.75 APE8-rot-na 18.22 APE67-dihe-in -71.49, -19.39 -64.21, -23.54 APE12-dist-na 14.7406 APE11-dist-na 10.5509 APE10-dist-na 11.0271 APE9-dist-in 6.6146 Y992F,C1008S PTR999,PTR1185,PTR1189,PTR1190 PTR999,PTR1185,PTR1189,PTR1190 XRAY 2.3 0.207 0.266 A 328.0 310.0 0 30 30 0 [[1023, 1292]] 1.0 4xlv Homo sapiens TYR_INSR_HUMAN TYR 1.7e-96 328.5 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR INSR INSR_HUMAN 1I44A P06213 1013 1310 1382.0 ACP:60300 ATPlike Inactive DFGin 6.6413 13.7197 None -58.16, -57.88 -145.23, -170.38 -78.54, 6.88 58.45, 76.71 123.48, 176.59 in-out in 9.122 Saltbr-out 5.8952 HRD-in -61.91, -52.97 77.04, -9.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -75.06 APE8-dihe-out -68.29, 48.19 APE8-rot-na 34.45 APE67-dihe-in -67.23, -7.11 -39.74, -51.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6829 C1008S,Y1011F,D1188A None None XRAY 2.4 0.21 0.268 A 306.0 282.0 16 30 14 16 [[1023, 1292]] 1.0 1i44 Homo sapiens TYR_INSR_HUMAN TYR 3.4e-96 327.5 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR TNK2 ACK1_HUMAN 1U54A Q07912 115 390 1038.0 ACP:101 ATPlike Inactive DFGin 6.3812 13.4263 ABAminus -129.39, -12.11 -146.47, 102.96 -102.84, 23.33 304.65, 105.91 -57.05, -37.37 in-in in 7.8643 Saltbr-in 2.6244 HRD-in -77.15, -49.8 83.51, -10.59 in-in-none SNCiin in-none ActLoopNT-in 2.8347 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.54 APE8-dihe-in -75.47, 123.76 APE8-rot-na 349.96 APE67-dihe-in -43.9, -19.78 -62.08, -52.54 APE12-dist-na 11.8082 APE11-dist-na 8.1412 APE10-dist-na 999.0 APE9-dist-in 6.0632 None PTR284 PTR284 XRAY 2.8 0.226 0.322 A 291.0 263.0 13 31 30 1 [[126, 387]] 1.0 1u54 Homo sapiens TYR_TNK2_HUMAN TYR 9e-86 293.3 1.0 259.0 259.0 269 270 271 273 275 158 177 181 249 251 250 252.0 312 300 295 294 293 292 291 290 289 206 Activated CDC42 kinase 1
TYR TNK2 ACK1_HUMAN 1U54B Q07912 117 388 1038.0 ACP:400 ATPlike Active DFGin 6.6155 13.3776 BLAminus -120.4, -155.16 27.84, 85.75 -104.36, 38.7 310.01, 93.15 -67.71, -28.73 in-in in 7.966 Saltbr-in 3.0206 HRD-in -109.84, -42.56 64.6, 13.11 in-in-in SNCiii in-in ActLoopNT-in 3.0144 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -150.8, 133.1 APE9-dihe-in -126.86, 129.0 APE8-dihe-in -43.1, 130.27 APE8-rot-na 329.12 APE67-dihe-in -70.13, -6.6 -62.78, -39.45 APE12-dist-na 12.6617 APE11-dist-na 7.6459 APE10-dist-na 10.9998 APE9-dist-in 5.8775 None None None XRAY 2.8 0.226 0.322 B 291.0 261.0 11 31 31 0 [[126, 387]] 1.0 1u54 Homo sapiens TYR_TNK2_HUMAN TYR 9e-86 293.3 1.0 259.0 259.0 269 270 271 273 275 158 177 181 249 251 250 252.0 312 300 295 294 293 292 291 290 289 206 Activated CDC42 kinase 1
AGC PRKACA KAPCA_MOUSE 4IACA P05132 16 351 351.0 ACP:60403 ATPlike Active DFGin 5.7549 14.3121 BLAminus -125.73, -177.16 59.8, 78.08 -94.31, 23.06 273.35, 54.81 -46.36, -37.92 in-in in 8.8851 Saltbr-in 2.7214 HRD-in -73.57, -53.97 72.67, 5.23 in-in-in SNCiii in-in ActLoopNT-in 2.9421 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.57, 156.93 APE9-dihe-na 137.19, -153.99 APE8-dihe-in -123.03, 128.21 APE8-rot-in 300.87 APE67-dihe-in -59.06, -23.99 -31.47, -61.7 APE12-dist-in 8.1573 APE11-dist-in 11.5147 APE10-dist-in 5.9848 APE9-dist-in 3.5015 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.15 0.181 0.212 A 356.0 336.0 0 25 25 0 [[44, 298]] 1.0 4iac Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CMGC MAPK14 MK14_MOUSE 8VMMA P47811 5 354 360.0 A1ACP:602 Type1 Inactive DFGin 10.9836 13.1585 None -98.06, 143.62 -67.61, -42.07 -138.88, 122.62 295.3, 103.53 -85.47, 178.15 in-in in 9.4266 Saltbr-in 2.5383 HRD-in -74.94, -56.81 76.36, -7.57 in-out-out SNCioo out-out ActLoopNT-out 21.1108 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 103.41 APE9-dihe-na -75.99, -11.35 APE8-dihe-out 77.98, -40.95 APE8-rot-in 311.13 APE67-dihe-in -68.54, -15.53 -53.31, -26.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.5031 APE9-dist-out 11.8253 None None None XRAY 2.4 0.207 0.263 A 367.0 341.0 9 25 16 9 [[24, 308]] 1.0 8vmm Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
OTHER PKNB PKNB_MYCTU 1O6YA P9WI81 3 278 626.0 ACP:1279 ATPlike None DFGin 5.3086 14.7801 BLAminus -139.04, -177.54 67.82, 83.57 -97.92, 24.81 285.65, 79.79 -51.43, -35.15 in-in in 8.2415 Saltbr-in 2.7925 HRD-in -70.46, -52.6 71.79, -5.94 in-in-none SNCiin in-none ActLoopNT-in 2.7524 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -69.25, -16.6 999.0, -48.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.193 0.23 A 299.0 260.0 16 31 15 16 [[11, 273]] 1.0 1o6y Mycobacterium tuberculosis OTHER_PKNB_MYCTU CAMK 6.4e-46 162.7 1.0 248.0 248.0 155 156 157 159 161 40 59 63 135 137 136 138.0 198 186 181 180 179 178 177 176 175 93 Serine/threonine-protein kinase PknB
OTHER PKNB PKNB_MYCTU 6I2PA P9WI81 1 278 626.0 ACP:301 ATPlike Inactive None 11.3179 16.9719 None -125.13, 175.99 66.11, 55.5 -97.33, 137.94 289.87, 87.88 -101.43, 158.5 in-out in 8.3833 Saltbr-out 4.1552 HRD-in -62.97, -54.02 77.2, -15.49 out-out-out SNCooo out-out ActLoopNT-out 7.9512 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iooo APE10-dihe-na -69.22, 139.86 APE9-dihe-na 130.91, -153.5 APE8-dihe-out -75.55, -19.27 APE8-rot-out 56.79 APE67-dihe-out -64.87, -19.1 65.77, 0.83 APE12-dist-in 13.4665 APE11-dist-out 18.4416 APE10-dist-out 19.0238 APE9-dist-out 10.6107 L33E TPO171,TPO173 TPO171,TPO173 XRAY 2.37 0.221 0.234 A 280.0 272.0 6 31 25 6 [[11, 273]] 1.0 6i2p Mycobacterium tuberculosis OTHER_PKNB_MYCTU CAMK 1.7e-46 164.7 1.0 248.0 248.0 155 156 157 159 161 40 59 63 135 137 136 138.0 198 186 181 180 179 178 177 176 175 93 Serine/threonine-protein kinase PknB
OTHER PKNB PKNB_MYCTU 6I2PB P9WI81 2 277 626.0 ACP:301 ATPlike Inactive None 11.7466 17.0944 None -128.89, 178.08 68.33, 50.19 -91.53, 128.09 288.96, 86.92 -86.75, 157.61 in-out in 8.3942 Saltbr-out 4.1975 HRD-in -57.76, -51.63 76.05, -15.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_onnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -18.66 APE8-rot-none 999.0 APE67-dihe-out -74.3, -17.9 61.65, 10.67 APE12-dist-out 17.4038 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 L33E TPO171,TPO173 TPO171,TPO173 XRAY 2.37 0.221 0.234 B 280.0 266.0 10 31 21 10 [[11, 273]] 1.0 6i2p Mycobacterium tuberculosis OTHER_PKNB_MYCTU CAMK 1.7e-46 164.7 1.0 248.0 248.0 155 156 157 159 161 40 59 63 135 137 136 138.0 198 186 181 180 179 178 177 176 175 93 Serine/threonine-protein kinase PknB

Ligand: ACP

Total number of chains: 8
Active chains: 1
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 62.5% 4F0FA
None None 2 25.0% 6I2PA
DFGin None 1 12.5% 8VMMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL ROCO4 ROCO4_DICDI 4F0FA Q6XHB2 1019 1292 1726.0 ACP:61301 ATPlike Inactive DFGin 6.9498 15.9628 BLAminus -130.66, 172.28 62.24, 70.89 -92.37, 29.04 286.11, 76.52 -66.1, -24.87 in-in in 8.4554 Saltbr-in 2.5726 HRD-in -73.46, -44.25 65.79, 5.9 in-in-out SNCiio in-out ActLoopNT-in 2.5989 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -114.23, 137.57 APE9-dihe-na -90.18, -37.76 APE8-dihe-in -70.88, 120.21 APE8-rot-na 222.83 APE67-dihe-in -78.4, -5.47 -115.68, -26.3 APE12-dist-in 10.1797 APE11-dist-in 12.5114 APE10-dist-out 9.2223 APE9-dist-out 8.2996 None None None XRAY 1.8 0.198 0.245 A 287.0 274.0 0 25 25 0 [[1026, 1291]] 1.0 4f0f Dictyostelium discoideum TKL_ROCO4_DICDI TKL 3.2e-59 206.6 2.0 266.0 265.0 1176 1177 1178 1180 1182 1055 1078 1082 1151 1153 1152 1154.0 1215 1201 1196 1195 1194 1193 1192 1191 1190 1106 Probable serine/threonine-protein kinase roco4
TKL ROCO4 ROCO4_DICDI 4F1OA Q6XHB2 1019 1292 1726.0 ACP:61301 ATPlike Inactive DFGin 7.1098 15.5425 BLAminus -139.35, 175.97 61.59, 71.39 -91.48, 35.72 286.47, 73.49 -70.25, -38.98 in-in in 8.0862 Saltbr-in 2.782 HRD-in -70.19, -38.92 67.65, -6.5 in-in-out SNCiio in-out ActLoopNT-in 2.7019 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -99.87, 151.06 APE9-dihe-na -83.99, -54.56 APE8-dihe-in -77.41, 78.95 APE8-rot-na 217.99 APE67-dihe-in -67.17, -15.56 -63.92, -29.08 APE12-dist-in 10.3481 APE11-dist-in 12.8064 APE10-dist-out 9.0723 APE9-dist-out 8.1398 None None None XRAY 2.3 0.252 0.296 A 287.0 274.0 0 25 25 0 [[1026, 1291]] 1.0 4f1o Dictyostelium discoideum TKL_ROCO4_DICDI TKL 1.1e-58 204.8 2.0 266.0 265.0 1176 1177 1178 1180 1182 1055 1078 1082 1151 1153 1152 1154.0 1215 1201 1196 1195 1194 1193 1192 1191 1190 1106 Probable serine/threonine-protein kinase roco4
TKL ROCO4 ROCO4_DICDI 4F1MA Q6XHB2 1019 1292 1726.0 ACP:61301,BTB:61302 ATPlike,Allosteric Inactive DFGin 6.7343 15.3101 BLAminus -135.93, 167.45 61.64, 76.62 -97.37, 30.41 286.17, 86.15 -92.2, 166.07 in-in in 8.1479 Saltbr-in 2.8434 HRD-in -65.4, -53.97 73.14, 3.41 in-in-out SNCiio in-out ActLoopNT-in 2.7042 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -114.68, 138.58 APE9-dihe-na -71.39, -65.99 APE8-dihe-in -65.85, 83.01 APE8-rot-na 289.29 APE67-dihe-in -75.86, -13.39 -67.18, -17.16 APE12-dist-in 10.0156 APE11-dist-in 11.7768 APE10-dist-out 8.6781 APE9-dist-out 7.7914 G1179S None None XRAY 2.04 0.263 0.294 A 287.0 274.0 0 25 25 0 [[1026, 1291]] 1.0 4f1m Dictyostelium discoideum TKL_ROCO4_DICDI TKL 3.2e-58 203.3 2.0 266.0 265.0 1176 1177 1178 1180 1182 1055 1078 1082 1151 1153 1152 1154.0 1215 1201 1196 1195 1194 1193 1192 1191 1190 1106 Probable serine/threonine-protein kinase roco4
AGC PRKACA KAPCA_MOUSE 4IACA P05132 16 351 351.0 ACP:60403 ATPlike Active DFGin 5.7549 14.3121 BLAminus -125.73, -177.16 59.8, 78.08 -94.31, 23.06 273.35, 54.81 -46.36, -37.92 in-in in 8.8851 Saltbr-in 2.7214 HRD-in -73.57, -53.97 72.67, 5.23 in-in-in SNCiii in-in ActLoopNT-in 2.9421 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.57, 156.93 APE9-dihe-na 137.19, -153.99 APE8-dihe-in -123.03, 128.21 APE8-rot-in 300.87 APE67-dihe-in -59.06, -23.99 -31.47, -61.7 APE12-dist-in 8.1573 APE11-dist-in 11.5147 APE10-dist-in 5.9848 APE9-dist-in 3.5015 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.15 0.181 0.212 A 356.0 336.0 0 25 25 0 [[44, 298]] 1.0 4iac Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CMGC MAPK14 MK14_MOUSE 8VMMA P47811 5 354 360.0 A1ACP:602 Type1 Inactive DFGin 10.9836 13.1585 None -98.06, 143.62 -67.61, -42.07 -138.88, 122.62 295.3, 103.53 -85.47, 178.15 in-in in 9.4266 Saltbr-in 2.5383 HRD-in -74.94, -56.81 76.36, -7.57 in-out-out SNCioo out-out ActLoopNT-out 21.1108 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 103.41 APE9-dihe-na -75.99, -11.35 APE8-dihe-out 77.98, -40.95 APE8-rot-in 311.13 APE67-dihe-in -68.54, -15.53 -53.31, -26.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.5031 APE9-dist-out 11.8253 None None None XRAY 2.4 0.207 0.263 A 367.0 341.0 9 25 16 9 [[24, 308]] 1.0 8vmm Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
OTHER PKNB PKNB_MYCTU 1O6YA P9WI81 3 278 626.0 ACP:1279 ATPlike None DFGin 5.3086 14.7801 BLAminus -139.04, -177.54 67.82, 83.57 -97.92, 24.81 285.65, 79.79 -51.43, -35.15 in-in in 8.2415 Saltbr-in 2.7925 HRD-in -70.46, -52.6 71.79, -5.94 in-in-none SNCiin in-none ActLoopNT-in 2.7524 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -69.25, -16.6 999.0, -48.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.193 0.23 A 299.0 260.0 16 31 15 16 [[11, 273]] 1.0 1o6y Mycobacterium tuberculosis OTHER_PKNB_MYCTU CAMK 6.4e-46 162.7 1.0 248.0 248.0 155 156 157 159 161 40 59 63 135 137 136 138.0 198 186 181 180 179 178 177 176 175 93 Serine/threonine-protein kinase PknB
OTHER PKNB PKNB_MYCTU 6I2PA P9WI81 1 278 626.0 ACP:301 ATPlike Inactive None 11.3179 16.9719 None -125.13, 175.99 66.11, 55.5 -97.33, 137.94 289.87, 87.88 -101.43, 158.5 in-out in 8.3833 Saltbr-out 4.1552 HRD-in -62.97, -54.02 77.2, -15.49 out-out-out SNCooo out-out ActLoopNT-out 7.9512 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iooo APE10-dihe-na -69.22, 139.86 APE9-dihe-na 130.91, -153.5 APE8-dihe-out -75.55, -19.27 APE8-rot-out 56.79 APE67-dihe-out -64.87, -19.1 65.77, 0.83 APE12-dist-in 13.4665 APE11-dist-out 18.4416 APE10-dist-out 19.0238 APE9-dist-out 10.6107 L33E TPO171,TPO173 TPO171,TPO173 XRAY 2.37 0.221 0.234 A 280.0 272.0 6 31 25 6 [[11, 273]] 1.0 6i2p Mycobacterium tuberculosis OTHER_PKNB_MYCTU CAMK 1.7e-46 164.7 1.0 248.0 248.0 155 156 157 159 161 40 59 63 135 137 136 138.0 198 186 181 180 179 178 177 176 175 93 Serine/threonine-protein kinase PknB
OTHER PKNB PKNB_MYCTU 6I2PB P9WI81 2 277 626.0 ACP:301 ATPlike Inactive None 11.7466 17.0944 None -128.89, 178.08 68.33, 50.19 -91.53, 128.09 288.96, 86.92 -86.75, 157.61 in-out in 8.3942 Saltbr-out 4.1975 HRD-in -57.76, -51.63 76.05, -15.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_onnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -18.66 APE8-rot-none 999.0 APE67-dihe-out -74.3, -17.9 61.65, 10.67 APE12-dist-out 17.4038 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 L33E TPO171,TPO173 TPO171,TPO173 XRAY 2.37 0.221 0.234 B 280.0 266.0 10 31 21 10 [[11, 273]] 1.0 6i2p Mycobacterium tuberculosis OTHER_PKNB_MYCTU CAMK 1.7e-46 164.7 1.0 248.0 248.0 155 156 157 159 161 40 59 63 135 137 136 138.0 198 186 181 180 179 178 177 176 175 93 Serine/threonine-protein kinase PknB