Protein kinases in complex with ACP

Total number of genes: 19
Total number of chains: 90
Spatial Dihedral Chains Representative
DFGin BLAminus 63 5G15A
DFGin BLAplus 2 6PNXB
DFGin ABAminus 5 6EQ9A
DFGin BLBminus 5 7KJCA
DFGin BLBplus 10 4ANBA
DFGin None 2 4C3PA
DFGinter None 2 4C3RA
None None 1 6C83A
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
AGC PRKCI KPCI_HUMAN Protein kinase C iota type 5LI9A 1.79 Active DFGin BLAminus in-in in-in ACP Type1
AGC RPS6KA1 KS6A1_HUMAN Ribosomal protein S6 kinase alpha-1 2Z7QA 2.0 Inactive DFGin BLBplus none-none out-out ACP Type1
CAMK AURKA AURKA_HUMAN Aurora kinase A 4C3PD 2.69 Inactive DFGin ABAminus out-out in-out ACP Type1
CAMK AURKA AURKA_HUMAN Aurora kinase A 5G15A 2.06 Inactive DFGin BLAminus out-out in-in ACP Type1
CAMK AURKA AURKA_HUMAN Aurora kinase A 6CPFA 2.3 None DFGin BLAminus out-none in-out ACP Type1
CAMK AURKA AURKA_HUMAN Aurora kinase A 4C3PA 2.69 Inactive DFGin None out-out in-out ACP Type1
CAMK AURKA AURKA_HUMAN Aurora kinase A 4C3RA 2.79 Inactive DFGinter None out-out out-out ACP Type1
CAMK AURKA AURKA_HUMAN Aurora kinase A 6C83B 2.55 Inactive DFGinter None out-out none-out ACP Type1
CAMK AURKA AURKA_HUMAN Aurora kinase A 6C83A 2.55 Inactive None None out-none none-out ACP Type1
CAMK DAPK1 DAPK1_HUMAN Death-associated protein kinase 1 3ZXTB 2.65 None DFGin BLAminus in-in in-none ACP Type1
CAMK DAPK1 DAPK1_HUMAN Death-associated protein kinase 1 3ZXTC 2.65 None DFGin BLAminus in-in in-none ACP Type1
CAMK DAPK1 DAPK1_HUMAN Death-associated protein kinase 1 3ZXTD 2.65 None DFGin BLAminus in-in in-none ACP Type1
CAMK DAPK1 DAPK1_HUMAN Death-associated protein kinase 1 3ZXTA 2.65 Inactive DFGin BLBminus in-in in-none ACP Type1
CK1 CSNK1D KC1D_HUMAN Casein kinase I isoform delta 6RU6A 2.05 Active DFGin BLAminus in-in in-in ACP Type1
CK1 CSNK1D KC1D_HUMAN Casein kinase I isoform delta 6RU6B 2.05 Active DFGin BLAminus in-in in-in ACP Type1
CMGC CSNK2A1 CSK21_HUMAN Casein kinase II subunit alpha 4NH1A 3.3 Active DFGin BLAminus in-in in-in ACP Type1
CMGC CSNK2A1 CSK21_HUMAN Casein kinase II subunit alpha 4NH1B 3.3 Active DFGin BLAminus in-in in-in ACP Type1
CMGC MAPK1 MK01_HUMAN Mitogen-activated protein kinase 1 5V60A 2.18 Active DFGin BLAminus in-in in-in ACP Type1
CMGC MAPK10 MK10_HUMAN Mitogen-activated protein kinase 10 6EQ9B 1.83 Inactive DFGin ABAminus in-in none-out ACP Type1
CMGC MAPK10 MK10_HUMAN Mitogen-activated protein kinase 10 6EQ9A 1.83 Inactive DFGin ABAminus in-out out-out ACP C15 Type1 Allosteric
OTHER RNASEL RN5A_HUMAN 2-5A-dependent ribonuclease 4OAVB 2.1 Active DFGin BLAminus in-in in-none ACP Type1
OTHER RNASEL RN5A_HUMAN 2-5A-dependent ribonuclease 4OAVD 2.1 Active DFGin BLAminus in-in in-none ACP Type1
STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 6U2GA 2.886 Inactive DFGin BLBplus out-out out-out ACP Type1
STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 4MNEA 2.848 Inactive DFGin BLBplus out-out out-out ACP 573 Type1 Type1
STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 4MNED 2.848 Inactive DFGin BLBplus out-out out-out ACP 573 Type1 Type1
STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 4AN9A 2.8 Inactive DFGin BLBplus out-out out-out ACP 2P7 Type1 Type3
STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 4MNEE 2.848 Inactive DFGin BLBplus out-out out-out ACP 573 Type1 Type3
STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 4MNEH 2.848 Inactive DFGin BLBplus out-out out-out ACP 573 573 Type1 Type3 Allosteric
STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 4AN2A 2.5 Inactive DFGin BLBplus out-out out-out EUI ACP Type3 Type1
STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 4ANBA 2.2 Inactive DFGin BLBplus out-out out-out YQY ACP Type3 Type1
TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf 6U2GB 2.886 Inactive DFGin BLBplus out-out out-out ACP Type1
TKL RIPK2 RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 5NG0A 2.0 Inactive DFGin BLAminus in-in in-out ACP Type1
TKL RIPK2 RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 5NG0B 2.0 Active DFGin BLAminus in-in in-in ACP Type1
TKL RIPK2 RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 5AR3A 3.23 Inactive DFGin BLAminus in-in in-out ACP Type1
TKL RIPK2 RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 5AR3B 3.23 None DFGin BLAminus in-in in-none ACP Type1
TYR EPHA2 EPHA2_HUMAN Ephrin type-A receptor 2 7KJAB 1.75 None DFGin BLAminus in-in none-none ACP Type1
TYR EPHA2 EPHA2_HUMAN Ephrin type-A receptor 2 7KJCA 2.3 Inactive DFGin BLBminus in-in out-in ACP Type1
TYR EPHA2 EPHA2_HUMAN Ephrin type-A receptor 2 7KJCB 2.3 Inactive DFGin BLBminus in-in none-none ACP Type1
TYR EPHA2 EPHA2_HUMAN Ephrin type-A receptor 2 7KJAA 1.75 Inactive DFGin BLBminus in-in none-none ACP Type1
TYR FGFR1 FGFR1_HUMAN Fibroblast growth factor receptor 1 3GQIA 2.5 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PWLA 2.4 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PWLB 2.4 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J96B 2.297 Inactive DFGin BLAminus in-out in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J98B 2.307 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PVFA 1.8 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 3CLYA 2.0 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J99A 1.847 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J99B 1.847 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J99C 1.847 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J99D 1.847 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PVYA 2.2 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PVYB 2.2 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PVYC 2.2 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PVYD 2.2 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J95A 2.377 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J95B 2.377 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J95C 2.377 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J95D 2.377 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PZ5A 2.4 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PZ5B 2.4 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J97A 2.548 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J97B 2.548 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J97C 2.548 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J97D 2.548 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PZPA 2.4 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PZPB 2.4 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PZRA 3.0 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PZRB 3.0 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 5UHNA 2.909 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 5UHNB 2.909 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 5UGXA 2.349 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 5UGXB 2.349 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 5UI0B 2.05 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2Q0BA 2.9 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2Q0BB 2.9 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PY3A 2.3 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PY3B 2.3 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 5EG3A 2.606 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 6V6QA 2.46 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 6V6QB 2.46 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 6V6QD 2.46 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 6V6QC 2.46 Inactive DFGin BLBminus in-in in-in ACP Type1
TYR FGFR3 FGFR3_HUMAN Fibroblast growth factor receptor 3 4K33A 2.341 Active DFGin BLAminus in-in in-in ACP Type1
TYR FGFR3 FGFR3_HUMAN Fibroblast growth factor receptor 3 6PNXA 2.199 Inactive DFGin BLAplus in-out out-in ACP Type1
TYR FGFR3 FGFR3_HUMAN Fibroblast growth factor receptor 3 6PNXB 2.199 Inactive DFGin BLAplus in-in out-in ACP Type1
TYR IGF1R IGF1R_HUMAN Insulin-like growth factor 1 receptor 1K3AA 2.1 Inactive DFGin ABAminus in-out in-in ACP Type1
TYR INSR INSR_HUMAN Insulin receptor 4XLVA 2.3 Active DFGin BLAminus in-in in-in ACP Type1
TYR INSR INSR_HUMAN Insulin receptor 1I44A 2.4 Inactive DFGin None in-out none-in ACP Type1
TYR TNK2 ACK1_HUMAN Activated CDC42 kinase 1 1U54A 2.8 Inactive DFGin ABAminus in-in in-in ACP Type1
TYR TNK2 ACK1_HUMAN Activated CDC42 kinase 1 1U54B 2.8 Active DFGin BLAminus in-in in-in ACP Type1

Protein kinases in complex with ACP

Total number of genes: 23
Total number of chains: 98
Spatial Dihedral Chains Representative
DFGin BLAminus 68 4F0FA
DFGin BLAplus 2 6PNXB
DFGin ABAminus 6 6EQ9A
DFGin BLBminus 5 7KJCA
DFGin BLBplus 10 4ANBA
DFGin None 2 4C3PA
DFGinter None 2 4C3RA
None None 3 6I2PA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Dictyostelium discoideum TKL ROCO4 ROCO4_DICDI Probable serine/threonine-protein kinase roco4 4F0FA 1.8 Inactive DFGin BLAminus in-in in-out ACP Type1
Dictyostelium discoideum TKL ROCO4 ROCO4_DICDI Probable serine/threonine-protein kinase roco4 4F1OA 2.3 Inactive DFGin BLAminus in-in in-out ACP Type1
Dictyostelium discoideum TKL ROCO4 ROCO4_DICDI Probable serine/threonine-protein kinase roco4 4F1MA 2.04 Inactive DFGin BLAminus in-in in-out ACP BTB Type1 Allosteric
Homo sapiens AGC PRKCI KPCI_HUMAN Protein kinase C iota type 5LI9A 1.79 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens AGC RPS6KA1 KS6A1_HUMAN Ribosomal protein S6 kinase alpha-1 2Z7QA 2.0 Inactive DFGin BLBplus none-none out-out ACP Type1
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 4C3PD 2.69 Inactive DFGin ABAminus out-out in-out ACP Type1
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 5G15A 2.06 Inactive DFGin BLAminus out-out in-in ACP Type1
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 6CPFA 2.3 None DFGin BLAminus out-none in-out ACP Type1
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 4C3PA 2.69 Inactive DFGin None out-out in-out ACP Type1
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 4C3RA 2.79 Inactive DFGinter None out-out out-out ACP Type1
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 6C83B 2.55 Inactive DFGinter None out-out none-out ACP Type1
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 6C83A 2.55 Inactive None None out-none none-out ACP Type1
Homo sapiens CAMK DAPK1 DAPK1_HUMAN Death-associated protein kinase 1 3ZXTB 2.65 None DFGin BLAminus in-in in-none ACP Type1
Homo sapiens CAMK DAPK1 DAPK1_HUMAN Death-associated protein kinase 1 3ZXTC 2.65 None DFGin BLAminus in-in in-none ACP Type1
Homo sapiens CAMK DAPK1 DAPK1_HUMAN Death-associated protein kinase 1 3ZXTD 2.65 None DFGin BLAminus in-in in-none ACP Type1
Homo sapiens CAMK DAPK1 DAPK1_HUMAN Death-associated protein kinase 1 3ZXTA 2.65 Inactive DFGin BLBminus in-in in-none ACP Type1
Homo sapiens CK1 CSNK1D KC1D_HUMAN Casein kinase I isoform delta 6RU6A 2.05 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens CK1 CSNK1D KC1D_HUMAN Casein kinase I isoform delta 6RU6B 2.05 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens CMGC CSNK2A1 CSK21_HUMAN Casein kinase II subunit alpha 4NH1A 3.3 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens CMGC CSNK2A1 CSK21_HUMAN Casein kinase II subunit alpha 4NH1B 3.3 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens CMGC MAPK1 MK01_HUMAN Mitogen-activated protein kinase 1 5V60A 2.18 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens CMGC MAPK10 MK10_HUMAN Mitogen-activated protein kinase 10 6EQ9B 1.83 Inactive DFGin ABAminus in-in none-out ACP Type1
Homo sapiens CMGC MAPK10 MK10_HUMAN Mitogen-activated protein kinase 10 6EQ9A 1.83 Inactive DFGin ABAminus in-out out-out ACP C15 Type1 Allosteric
Homo sapiens OTHER RNASEL RN5A_HUMAN 2-5A-dependent ribonuclease 4OAVB 2.1 Active DFGin BLAminus in-in in-none ACP Type1
Homo sapiens OTHER RNASEL RN5A_HUMAN 2-5A-dependent ribonuclease 4OAVD 2.1 Active DFGin BLAminus in-in in-none ACP Type1
Homo sapiens STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 6U2GA 2.886 Inactive DFGin BLBplus out-out out-out ACP Type1
Homo sapiens STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 4MNEA 2.848 Inactive DFGin BLBplus out-out out-out ACP 573 Type1 Type1
Homo sapiens STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 4MNED 2.848 Inactive DFGin BLBplus out-out out-out ACP 573 Type1 Type1
Homo sapiens STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 4AN9A 2.8 Inactive DFGin BLBplus out-out out-out ACP 2P7 Type1 Type3
Homo sapiens STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 4MNEE 2.848 Inactive DFGin BLBplus out-out out-out ACP 573 Type1 Type3
Homo sapiens STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 4MNEH 2.848 Inactive DFGin BLBplus out-out out-out ACP 573 573 Type1 Type3 Allosteric
Homo sapiens STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 4AN2A 2.5 Inactive DFGin BLBplus out-out out-out EUI ACP Type3 Type1
Homo sapiens STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 4ANBA 2.2 Inactive DFGin BLBplus out-out out-out YQY ACP Type3 Type1
Homo sapiens TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf 6U2GB 2.886 Inactive DFGin BLBplus out-out out-out ACP Type1
Homo sapiens TKL RIPK2 RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 5NG0A 2.0 Inactive DFGin BLAminus in-in in-out ACP Type1
Homo sapiens TKL RIPK2 RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 5NG0B 2.0 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TKL RIPK2 RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 5AR3A 3.23 Inactive DFGin BLAminus in-in in-out ACP Type1
Homo sapiens TKL RIPK2 RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 5AR3B 3.23 None DFGin BLAminus in-in in-none ACP Type1
Homo sapiens TYR EPHA2 EPHA2_HUMAN Ephrin type-A receptor 2 7KJAB 1.75 None DFGin BLAminus in-in none-none ACP Type1
Homo sapiens TYR EPHA2 EPHA2_HUMAN Ephrin type-A receptor 2 7KJCA 2.3 Inactive DFGin BLBminus in-in out-in ACP Type1
Homo sapiens TYR EPHA2 EPHA2_HUMAN Ephrin type-A receptor 2 7KJCB 2.3 Inactive DFGin BLBminus in-in none-none ACP Type1
Homo sapiens TYR EPHA2 EPHA2_HUMAN Ephrin type-A receptor 2 7KJAA 1.75 Inactive DFGin BLBminus in-in none-none ACP Type1
Homo sapiens TYR FGFR1 FGFR1_HUMAN Fibroblast growth factor receptor 1 3GQIA 2.5 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PWLA 2.4 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PWLB 2.4 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J96B 2.297 Inactive DFGin BLAminus in-out in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J98B 2.307 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PVFA 1.8 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 3CLYA 2.0 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J99A 1.847 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J99B 1.847 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J99C 1.847 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J99D 1.847 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PVYA 2.2 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PVYB 2.2 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PVYC 2.2 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PVYD 2.2 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J95A 2.377 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J95B 2.377 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J95C 2.377 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J95D 2.377 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PZ5A 2.4 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PZ5B 2.4 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J97A 2.548 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J97B 2.548 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J97C 2.548 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 4J97D 2.548 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PZPA 2.4 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PZPB 2.4 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PZRA 3.0 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PZRB 3.0 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 5UHNA 2.909 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 5UHNB 2.909 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 5UGXA 2.349 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 5UGXB 2.349 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 5UI0B 2.05 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2Q0BA 2.9 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2Q0BB 2.9 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PY3A 2.3 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 2PY3B 2.3 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 5EG3A 2.606 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 6V6QA 2.46 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 6V6QB 2.46 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 6V6QD 2.46 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR2 FGFR2_HUMAN Fibroblast growth factor receptor 2 6V6QC 2.46 Inactive DFGin BLBminus in-in in-in ACP Type1
Homo sapiens TYR FGFR3 FGFR3_HUMAN Fibroblast growth factor receptor 3 4K33A 2.341 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR FGFR3 FGFR3_HUMAN Fibroblast growth factor receptor 3 6PNXA 2.199 Inactive DFGin BLAplus in-out out-in ACP Type1
Homo sapiens TYR FGFR3 FGFR3_HUMAN Fibroblast growth factor receptor 3 6PNXB 2.199 Inactive DFGin BLAplus in-in out-in ACP Type1
Homo sapiens TYR IGF1R IGF1R_HUMAN Insulin-like growth factor 1 receptor 1K3AA 2.1 Inactive DFGin ABAminus in-out in-in ACP Type1
Homo sapiens TYR INSR INSR_HUMAN Insulin receptor 4XLVA 2.3 Active DFGin BLAminus in-in in-in ACP Type1
Homo sapiens TYR INSR INSR_HUMAN Insulin receptor 1I44A 2.4 Inactive DFGin None in-out none-in ACP Type1
Homo sapiens TYR TNK2 ACK1_HUMAN Activated CDC42 kinase 1 1U54A 2.8 Inactive DFGin ABAminus in-in in-in ACP Type1
Homo sapiens TYR TNK2 ACK1_HUMAN Activated CDC42 kinase 1 1U54B 2.8 Active DFGin BLAminus in-in in-in ACP Type1
Mus musculus AGC PRKACA KAPCA_MOUSE cAMP-dependent protein kinase catalytic subunit alpha 4IACA 2.15 Active DFGin BLAminus in-in in-in ACP Type1
Mycobacterium tuberculosis OTHER PKNB PKNB_MYCTU Serine/threonine-protein kinase PknB 1O6YA 2.2 None DFGin BLAminus in-in in-none ACP Type1
Mycobacterium tuberculosis OTHER PKNB PKNB_MYCTU Serine/threonine-protein kinase PknB 6I2PA 2.37 Inactive None None in-out out-out ACP Type1
Mycobacterium tuberculosis OTHER PKNB PKNB_MYCTU Serine/threonine-protein kinase PknB 6I2PB 2.37 Inactive None None in-out none-none ACP Type1
Serratia sp. OTHER PPKA A0A1S4NYE5_SERSF PpkA N terminal 5X1SA 1.45 Inactive DFGin ABAminus in-out out-out ACP Type1

Protein kinases in complex with ACP

Total number of genes: 4
Total number of chains: 8
Spatial Dihedral Chains Representative
DFGin BLAminus 5 4F0FA
DFGin ABAminus 1 5X1SA
None None 2 6I2PA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Dictyostelium discoideum TKL ROCO4 ROCO4_DICDI Probable serine/threonine-protein kinase roco4 4F0FA 1.8 Inactive DFGin BLAminus in-in in-out ACP Type1
Dictyostelium discoideum TKL ROCO4 ROCO4_DICDI Probable serine/threonine-protein kinase roco4 4F1OA 2.3 Inactive DFGin BLAminus in-in in-out ACP Type1
Dictyostelium discoideum TKL ROCO4 ROCO4_DICDI Probable serine/threonine-protein kinase roco4 4F1MA 2.04 Inactive DFGin BLAminus in-in in-out ACP BTB Type1 Allosteric
Mus musculus AGC PRKACA KAPCA_MOUSE cAMP-dependent protein kinase catalytic subunit alpha 4IACA 2.15 Active DFGin BLAminus in-in in-in ACP Type1
Mycobacterium tuberculosis OTHER PKNB PKNB_MYCTU Serine/threonine-protein kinase PknB 1O6YA 2.2 None DFGin BLAminus in-in in-none ACP Type1
Mycobacterium tuberculosis OTHER PKNB PKNB_MYCTU Serine/threonine-protein kinase PknB 6I2PA 2.37 Inactive None None in-out out-out ACP Type1
Mycobacterium tuberculosis OTHER PKNB PKNB_MYCTU Serine/threonine-protein kinase PknB 6I2PB 2.37 Inactive None None in-out none-none ACP Type1
Serratia sp. OTHER PPKA A0A1S4NYE5_SERSF PpkA N terminal 5X1SA 1.45 Inactive DFGin ABAminus in-out out-out ACP Type1