FGFR3 (Fibroblast growth factor receptor 3)

Group: TYR
Uniprot: FGFR3_HUMAN
Domain boundary: 472 - 750


Total number of chains: 14
Spatial Dihedral Chains Representative
DFGin BLAminus 5 AF-P22607-K1A
DFGin BLAplus 8 8UDTA
DFGin BLBplus 1 8UDUA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P22607-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 464 - 758 None None 0
4K33A 2.341 Active DFGin BLAminus in-in in-in ACP Type1 459 - 755 C482A,C582S,K650E None 0
6LVMA 2.53 Active DFGin BLAminus in-in in-in EVR Type1.5_Back 472 - 755 None X577,X647,X648 0
7DHLA 2.57 Active DFGin BLAminus in-in in-in H6X Type1.5_Back 472 - 755 None X577,X647,X648 0
8UDUB 1.737 Active DFGin BLAminus in-in in-in WIQ Type1.5_Front 459 - 755 P572S,P573G None 1
8UDTA 2.829 Inactive DFGin BLAplus in-out out-out MLT MLT WGF Allosteric Allosteric Type1.5_Front 457 - 756 P572S,P573G None 4
6PNXA 2.199 Inactive DFGin BLAplus in-out out-in ACP Type1 456 - 757 C482A,C582S,R669E None 0
6PNXB 2.199 Inactive DFGin BLAplus in-in out-in ACP Type1 455 - 756 C482A,C582S,R669E None 0
8UDVA 2.348 Inactive DFGin BLAplus in-in out-out WIQ Type1.5_Back 458 - 755 V555M None 7
8UDVB 2.348 Inactive DFGin BLAplus in-in out-out WIQ Type1.5_Back 455 - 755 V555M None 8
8UDVC 2.348 Inactive DFGin BLAplus in-in none-out WIQ Type1.5_Back 458 - 755 V555M None 16
8UDTB 2.829 Inactive DFGin BLAplus in-out out-out WGF Type1.5_Front 457 - 754 P572S,P573G None 3
8UDTC 2.829 Inactive DFGin BLAplus in-out out-out WGF Type1.5_Front 457 - 756 P572S,P573G None 4
8UDUA 1.737 Inactive DFGin BLBplus in-in none-out WIQ Type1.5_Back 460 - 756 P572S,P573G None 8

FGFR3 (Fibroblast growth factor receptor 3)

Group: TYR
Total number of chains: 14
Spatial Dihedral Chains Representative
DFGin BLAminus 5 AF-P22607-K1A
DFGin BLAplus 8 8UDTA
DFGin BLBplus 1 8UDUA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens FGFR3_HUMAN AF-P22607-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 464 - 758 None None 0
Homo sapiens FGFR3_HUMAN 4K33A 2.341 Active DFGin BLAminus in-in in-in ACP Type1 459 - 755 C482A,C582S,K650E None 0
Homo sapiens FGFR3_HUMAN 6LVMA 2.53 Active DFGin BLAminus in-in in-in EVR Type1.5_Back 472 - 755 None X577,X647,X648 0
Homo sapiens FGFR3_HUMAN 7DHLA 2.57 Active DFGin BLAminus in-in in-in H6X Type1.5_Back 472 - 755 None X577,X647,X648 0
Homo sapiens FGFR3_HUMAN 8UDUB 1.737 Active DFGin BLAminus in-in in-in WIQ Type1.5_Front 459 - 755 P572S,P573G None 1
Homo sapiens FGFR3_HUMAN 8UDTA 2.829 Inactive DFGin BLAplus in-out out-out MLT MLT WGF Allosteric Allosteric Type1.5_Front 457 - 756 P572S,P573G None 4
Homo sapiens FGFR3_HUMAN 6PNXA 2.199 Inactive DFGin BLAplus in-out out-in ACP Type1 456 - 757 C482A,C582S,R669E None 0
Homo sapiens FGFR3_HUMAN 6PNXB 2.199 Inactive DFGin BLAplus in-in out-in ACP Type1 455 - 756 C482A,C582S,R669E None 0
Homo sapiens FGFR3_HUMAN 8UDVA 2.348 Inactive DFGin BLAplus in-in out-out WIQ Type1.5_Back 458 - 755 V555M None 7
Homo sapiens FGFR3_HUMAN 8UDVB 2.348 Inactive DFGin BLAplus in-in out-out WIQ Type1.5_Back 455 - 755 V555M None 8
Homo sapiens FGFR3_HUMAN 8UDVC 2.348 Inactive DFGin BLAplus in-in none-out WIQ Type1.5_Back 458 - 755 V555M None 16
Homo sapiens FGFR3_HUMAN 8UDTB 2.829 Inactive DFGin BLAplus in-out out-out WGF Type1.5_Front 457 - 754 P572S,P573G None 3
Homo sapiens FGFR3_HUMAN 8UDTC 2.829 Inactive DFGin BLAplus in-out out-out WGF Type1.5_Front 457 - 756 P572S,P573G None 4
Homo sapiens FGFR3_HUMAN 8UDUA 1.737 Inactive DFGin BLBplus in-in none-out WIQ Type1.5_Back 460 - 756 P572S,P573G None 8

FGFR3 (Fibroblast growth factor receptor 3)

No non-human structures known.