MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)

Group: STE
Uniprot: MP2K1_HUMAN
Domain boundary: 68 - 361


Total number of chains: 84
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-Q02750-K1A
DFGin BLBminus 2 8CHFE
DFGin BLBplus 72 4ANBA
DFGin None 2 5YT3B
DFGinter None 1 5YT3A
DFGout None 1 5HZEA
None None 5 7F2XA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-Q02750-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 60 - 369 None None 0
8CHFE 4.25 Inactive DFGin BLBminus out-out out-out No_ligand No_ligand 62 - 379 S218A,S222A None 0
8CHFF 4.25 Inactive DFGin BLBminus out-out out-out No_ligand No_ligand 62 - 379 S218A,S222A None 0
7PQVA 2.13 Inactive DFGin BLBplus out-out out-out 80C Type1 39 - 382 None None 3
3ZLSA 2.5 Inactive DFGin BLBplus out-out out-out 92P Type1 39 - 382 S298N,S299K,Y300K None 0
3ZLXA 2.2 Inactive DFGin BLBplus out-out out-out 5EZ Type1 39 - 382 S298N,S299K,Y300K None 3
3ZM4A 2.37 Inactive DFGin BLBplus out-out out-out 22T Type1 40 - 382 S298N,S299K,Y300K None 4
5BX0A 2.93 Inactive DFGin BLBplus out-out out-out 4W5 Type1 39 - 382 None None 0
7XNCA 2.1 Inactive DFGin BLBplus out-out out-out GIK Type1 37 - 382 S298N,S299K,Y300K None 3
3ZLYA 2.11 Inactive DFGin BLBplus out-out out-out YSO Type1 40 - 382 S298N,S299N,Y300K None 3
5EYMA 2.7 Inactive DFGin BLBplus out-out out-none 5U5 Type1 41 - 381 S298N,S299K,Y300F None 6
5EYMB 2.7 Inactive DFGin BLBplus out-out out-none 5U5 Type1 41 - 381 S298N,S299K,Y300F None 6
3EQDA 2.1 Inactive DFGin BLBplus out-out out-out AGS Type1 39 - 382 S298N,S299K,Y300F None 0
3EQFA 2.7 Inactive DFGin BLBplus out-out out-out KSA Type1 39 - 381 S298N,S299K,Y300F None 0
3EQIA 1.9 Inactive DFGin BLBplus out-out out-out ADP Type1 39 - 382 S298N,S299K,Y300F None 0
5YT3C 2.9 Inactive DFGin BLBplus out-none none-none ANP Type1 40 - 382 S218D,S222D,T292A,S298A None 17
6U2GA 2.886 Inactive DFGin BLBplus out-out out-out ACP Type1 43 - 383 None None 0
6V2WB 3.12 Inactive DFGin BLBplus out-out out-out ANP Type1 40 - 383 S218A,S222A None 0
3ZLWA 2.12 Inactive DFGin BLBplus out-out out-out MT8 Type1 39 - 382 S298N,S299K,Y300F None 3
4MNEA 2.848 Inactive DFGin BLBplus out-out out-out ACP 573 Type1 Type1 63 - 379 None None 0
4MNED 2.848 Inactive DFGin BLBplus out-out out-out ACP 573 Type1 Type1 66 - 382 None None 0
8DGSB 4.3 Inactive DFGin BLBplus out-out out-out AGS LCJ Type1 Type1 38 - 383 S218A,S222A None 0
4AN3A 2.1 Inactive DFGin BLBplus out-out out-out ATP 5Y0 Type1 Type3 61 - 381 S218E,S222E,G328A None 2
4AN9A 2.8 Inactive DFGin BLBplus out-out out-out ACP 2P7 Type1 Type3 61 - 381 S218E,S222E,G328A None 1
3SLSA 2.3 Inactive DFGin BLBplus out-out out-out ANP 77D Type1 Type3 45 - 383 None None 6
3SLSB 2.3 Inactive DFGin BLBplus out-out out-out ANP 77D Type1 Type3 45 - 383 None None 5
7B3MA 2.3 Inactive DFGin BLBplus out-out out-out ANP SU5 Type1 Type3 37 - 382 None None 5
7B3MB 2.3 Inactive DFGin BLBplus out-out out-out ANP SU5 Type1 Type3 37 - 382 None None 4
7B7RA 1.7 Inactive DFGin BLBplus out-out out-out ANP T1K Type1 Type3 37 - 382 None None 5
7B7RB 1.7 Inactive DFGin BLBplus out-out out-none ANP T1K Type1 Type3 39 - 382 None None 5
7B94A 2.0 Inactive DFGin BLBplus out-out out-out ANP T3W Type1 Type3 37 - 382 None None 5
7B94B 2.0 Inactive DFGin BLBplus out-out out-none ANP T3W Type1 Type3 41 - 382 None None 5
7B9LA 1.7 Inactive DFGin BLBplus out-out out-none ANP T4N Type1 Type3 37 - 382 None None 7
7B9LB 1.7 Inactive DFGin BLBplus out-out out-none ANP T4N Type1 Type3 41 - 381 None None 6
3ORNA 2.8 Inactive DFGin BLBplus out-out out-out ANP 3OR Type1 Type3 62 - 380 None None 0
3OS3A 2.8 Inactive DFGin BLBplus out-out out-out ATP 3OS Type1 Type3 62 - 378 None None 0
3WIGA 2.7 Inactive DFGin BLBplus out-out out-out ANP CHU Type1 Type3 62 - 380 None None 0
3DV3A 2.3 Inactive DFGin BLBplus out-out out-out ATP MEK Type1 Type3 62 - 382 None None 3
3MBLA 2.6 Inactive DFGin BLBplus out-out out-out ADP LSG Type1 Type3 62 - 381 None None 0
3PP1A 2.7 Inactive DFGin BLBplus out-out out-out ATP IZG Type1 Type3 62 - 382 None None 0
3EQBA 2.62 Inactive DFGin BLBplus out-out out-out ATP LUG Type1 Type3 62 - 382 None None 3
4U80A 2.8 Inactive DFGin BLBplus out-out out-out ANP 3EX Type1 Type3 62 - 379 None None 3
1S9JA 2.4 Inactive DFGin BLBplus out-out out-out ATP BBM Type1 Type3 62 - 382 None None 3
3DY7A 2.7 Inactive DFGin BLBplus out-out out-out ATP 1CX Type1 Type3 62 - 364 None None 3
3E8NA 2.5 Inactive DFGin BLBplus out-out out-out ATP VRA Type1 Type3 62 - 382 None None 1
3VVHA 2.0 Inactive DFGin BLBplus out-out out-none ATP 4BM Type1 Type3 62 - 382 None None 5
3VVHB 2.0 Inactive DFGin BLBplus out-out out-out ATP 4BM Type1 Type3 62 - 382 None None 0
3VVHC 2.0 Inactive DFGin BLBplus out-out out-out ATP 4BM Type1 Type3 62 - 381 None None 0
4ARKA 2.6 Inactive DFGin BLBplus out-out out-out ADP M3K Type1 Type3 62 - 382 None None 0
4LMNA 2.8 Inactive DFGin BLBplus out-out out-out ANP EUI Type1 Type3 62 - 382 None None 0
4MNEE 2.848 Inactive DFGin BLBplus out-out out-out ACP 573 Type1 Type3 62 - 379 None None 0
3EQGA 2.5 Inactive DFGin BLBplus out-out out-out ADP 4BM Type1 Type3 39 - 381 S298N,S299K,Y300F None 0
7UMBC 3.231 Inactive DFGin BLBplus out-out out-out ANP U9F Type1 Type3 41 - 381 None None 0
6PP9B 2.59 Inactive DFGin BLBplus out-out out-out ANP LCJ Type1 Type3 38 - 383 S218A,S222A None 0
7M0VB 3.16 Inactive DFGin BLBplus out-out out-out ANP EUI Type1 Type3 42 - 383 S218A,S222A None 0
7M0WB 3.09 Inactive DFGin BLBplus out-out out-out ANP QOA Type1 Type3 42 - 383 S218A,S222A None 0
7M0XB 2.47 Inactive DFGin BLBplus out-out out-out ANP 4BM Type1 Type3 40 - 383 S218A,S222A None 0
7M0YB 3.45 Inactive DFGin BLBplus out-out out-out ANP QOM Type1 Type3 43 - 382 S218A,S222A None 0
7M0ZB 3.12 Inactive DFGin BLBplus out-out out-out ANP CHU Type1 Type3 42 - 383 S218A,S222A None 0
8DGTB 3.9 Inactive DFGin BLBplus out-out out-out AGS LCJ Type1 Type3 43 - 385 S218A,S222A None 0
6NYBB 4.1 Inactive DFGin BLBplus out-out out-out ADP LCJ Type1 Type3 56 - 383 S218A,S222A None 0
4MNEH 2.848 Inactive DFGin BLBplus out-out out-out ACP 573 573 Type1 Type3 Allosteric 66 - 380 None None 0
7XLPA 2.1 Inactive DFGin BLBplus out-out out-out FZC Type1.5_Back 37 - 382 S298N,S299K,Y300K None 4
7MFDB 3.66 Inactive DFGin BLBplus out-out out-out CHU Type3 52 - 383 None None 0
4AN2A 2.5 Inactive DFGin BLBplus out-out out-out EUI ACP Type3 Type1 61 - 381 S218E,S222E,G328A None 0
4ANBA 2.2 Inactive DFGin BLBplus out-out out-out YQY ACP Type3 Type1 61 - 381 S218E,S222E,G328A None 0
2P55A 2.8 Inactive DFGin BLBplus out-out out-out MRA ATP Type3 Type1 62 - 382 None None 3
4U7ZA 2.805 Inactive DFGin BLBplus out-out out-out 3EW ANP Type3 Type1 62 - 382 None None 1
4U81A 2.701 Inactive DFGin BLBplus out-out out-out 3EY ANP Type3 Type1 62 - 382 None None 3
3V01A 2.705 Inactive DFGin BLBplus out-out out-out 3V0 ATP Type3 Type1 62 - 382 None None 3
3V04A 2.7 Inactive DFGin BLBplus out-out out-out V04 ATP Type3 Type1 62 - 382 None None 3
3EQCA 1.8 Inactive DFGin BLBplus out-out out-out 3BM AGS Type3 Type1 39 - 382 S298N,S299K,Y300F None 3
3EQHA 2.0 Inactive DFGin BLBplus out-out out-out 5BM ADP Type3 Type1 39 - 381 S298N,S299K,Y300F None 0
7M0TB 3.19 Inactive DFGin BLBplus out-out out-out 3EW ANP Type3 Type1 42 - 383 S218A,S222A None 0
7M0UB 3.09 Inactive DFGin BLBplus out-out out-out QO7 ANP Type3 Type1 43 - 385 S218A,S222A None 0
5YT3B 2.9 Inactive DFGin None out-out out-out ANP Type1 40 - 382 S218D,S222D,T292A,S298A None 0
5YT3D 2.9 Inactive DFGin None out-out out-out ANP Type1 39 - 382 S218D,S222D,T292A,S298A None 0
5YT3A 2.9 Inactive DFGinter None out-out none-none ANP Type1 39 - 382 S218D,S222D,T292A,S298A None 14
5HZEA 2.4 Inactive DFGout None out-out none-out E62 Type1 43 - 382 S298N,S299K,Y300F None 0
7F2XA 2.007 Inactive None None out-out out-out ANP Type1 45 - 382 None None 0
3W8QA 2.2 Inactive None None out-out out-out AGS Type1 39 - 382 T292A,S298A None 0
6Q0TC 5.7 Inactive None None out-none out-out LCJ AGS Type1 Type1 43 - 379 S218A,S222A None 0
6Q0JC 4.9 Inactive None None out-none out-out LCJ AGS Type1 Type1 43 - 379 S218A,S222A None 0
6Q0JD 4.9 Inactive None None out-none out-out LCJ AGS Type1 Type1 43 - 379 S218A,S222A None 0

MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)

Group: STE
Total number of chains: 98
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-Q02750-K1A
DFGin BLBminus 2 8CHFE
DFGin BLBplus 86 4ANBA
DFGin None 2 5YT3B
DFGinter None 1 5YT3A
DFGout None 1 5HZEA
None None 5 7F2XA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens MP2K1_HUMAN AF-Q02750-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 60 - 369 None None 0
Homo sapiens MP2K1_HUMAN 8CHFE 4.25 Inactive DFGin BLBminus out-out out-out No_ligand No_ligand 62 - 379 S218A,S222A None 0
Homo sapiens MP2K1_HUMAN 8CHFF 4.25 Inactive DFGin BLBminus out-out out-out No_ligand No_ligand 62 - 379 S218A,S222A None 0
Homo sapiens MP2K1_HUMAN 7PQVA 2.13 Inactive DFGin BLBplus out-out out-out 80C Type1 39 - 382 None None 3
Homo sapiens MP2K1_HUMAN 3ZLSA 2.5 Inactive DFGin BLBplus out-out out-out 92P Type1 39 - 382 S298N,S299K,Y300K None 0
Homo sapiens MP2K1_HUMAN 3ZLXA 2.2 Inactive DFGin BLBplus out-out out-out 5EZ Type1 39 - 382 S298N,S299K,Y300K None 3
Homo sapiens MP2K1_HUMAN 3ZM4A 2.37 Inactive DFGin BLBplus out-out out-out 22T Type1 40 - 382 S298N,S299K,Y300K None 4
Homo sapiens MP2K1_HUMAN 5BX0A 2.93 Inactive DFGin BLBplus out-out out-out 4W5 Type1 39 - 382 None None 0
Homo sapiens MP2K1_HUMAN 7XNCA 2.1 Inactive DFGin BLBplus out-out out-out GIK Type1 37 - 382 S298N,S299K,Y300K None 3
Homo sapiens MP2K1_HUMAN 3ZLYA 2.11 Inactive DFGin BLBplus out-out out-out YSO Type1 40 - 382 S298N,S299N,Y300K None 3
Homo sapiens MP2K1_HUMAN 5EYMA 2.7 Inactive DFGin BLBplus out-out out-none 5U5 Type1 41 - 381 S298N,S299K,Y300F None 6
Homo sapiens MP2K1_HUMAN 5EYMB 2.7 Inactive DFGin BLBplus out-out out-none 5U5 Type1 41 - 381 S298N,S299K,Y300F None 6
Homo sapiens MP2K1_HUMAN 3EQDA 2.1 Inactive DFGin BLBplus out-out out-out AGS Type1 39 - 382 S298N,S299K,Y300F None 0
Homo sapiens MP2K1_HUMAN 3EQFA 2.7 Inactive DFGin BLBplus out-out out-out KSA Type1 39 - 381 S298N,S299K,Y300F None 0
Homo sapiens MP2K1_HUMAN 3EQIA 1.9 Inactive DFGin BLBplus out-out out-out ADP Type1 39 - 382 S298N,S299K,Y300F None 0
Homo sapiens MP2K1_HUMAN 5YT3C 2.9 Inactive DFGin BLBplus out-none none-none ANP Type1 40 - 382 S218D,S222D,T292A,S298A None 17
Homo sapiens MP2K1_HUMAN 6U2GA 2.886 Inactive DFGin BLBplus out-out out-out ACP Type1 43 - 383 None None 0
Homo sapiens MP2K1_HUMAN 6V2WB 3.12 Inactive DFGin BLBplus out-out out-out ANP Type1 40 - 383 S218A,S222A None 0
Homo sapiens MP2K1_HUMAN 3ZLWA 2.12 Inactive DFGin BLBplus out-out out-out MT8 Type1 39 - 382 S298N,S299K,Y300F None 3
Homo sapiens MP2K1_HUMAN 4MNEA 2.848 Inactive DFGin BLBplus out-out out-out ACP 573 Type1 Type1 63 - 379 None None 0
Homo sapiens MP2K1_HUMAN 4MNED 2.848 Inactive DFGin BLBplus out-out out-out ACP 573 Type1 Type1 66 - 382 None None 0
Homo sapiens MP2K1_HUMAN 8DGSB 4.3 Inactive DFGin BLBplus out-out out-out AGS LCJ Type1 Type1 38 - 383 S218A,S222A None 0
Homo sapiens MP2K1_HUMAN 4AN3A 2.1 Inactive DFGin BLBplus out-out out-out ATP 5Y0 Type1 Type3 61 - 381 S218E,S222E,G328A None 2
Homo sapiens MP2K1_HUMAN 4AN9A 2.8 Inactive DFGin BLBplus out-out out-out ACP 2P7 Type1 Type3 61 - 381 S218E,S222E,G328A None 1
Homo sapiens MP2K1_HUMAN 3SLSA 2.3 Inactive DFGin BLBplus out-out out-out ANP 77D Type1 Type3 45 - 383 None None 6
Homo sapiens MP2K1_HUMAN 3SLSB 2.3 Inactive DFGin BLBplus out-out out-out ANP 77D Type1 Type3 45 - 383 None None 5
Homo sapiens MP2K1_HUMAN 7B3MA 2.3 Inactive DFGin BLBplus out-out out-out ANP SU5 Type1 Type3 37 - 382 None None 5
Homo sapiens MP2K1_HUMAN 7B3MB 2.3 Inactive DFGin BLBplus out-out out-out ANP SU5 Type1 Type3 37 - 382 None None 4
Homo sapiens MP2K1_HUMAN 7B7RA 1.7 Inactive DFGin BLBplus out-out out-out ANP T1K Type1 Type3 37 - 382 None None 5
Homo sapiens MP2K1_HUMAN 7B7RB 1.7 Inactive DFGin BLBplus out-out out-none ANP T1K Type1 Type3 39 - 382 None None 5
Homo sapiens MP2K1_HUMAN 7B94A 2.0 Inactive DFGin BLBplus out-out out-out ANP T3W Type1 Type3 37 - 382 None None 5
Homo sapiens MP2K1_HUMAN 7B94B 2.0 Inactive DFGin BLBplus out-out out-none ANP T3W Type1 Type3 41 - 382 None None 5
Homo sapiens MP2K1_HUMAN 7B9LA 1.7 Inactive DFGin BLBplus out-out out-none ANP T4N Type1 Type3 37 - 382 None None 7
Homo sapiens MP2K1_HUMAN 7B9LB 1.7 Inactive DFGin BLBplus out-out out-none ANP T4N Type1 Type3 41 - 381 None None 6
Homo sapiens MP2K1_HUMAN 3ORNA 2.8 Inactive DFGin BLBplus out-out out-out ANP 3OR Type1 Type3 62 - 380 None None 0
Homo sapiens MP2K1_HUMAN 3OS3A 2.8 Inactive DFGin BLBplus out-out out-out ATP 3OS Type1 Type3 62 - 378 None None 0
Homo sapiens MP2K1_HUMAN 3WIGA 2.7 Inactive DFGin BLBplus out-out out-out ANP CHU Type1 Type3 62 - 380 None None 0
Homo sapiens MP2K1_HUMAN 3DV3A 2.3 Inactive DFGin BLBplus out-out out-out ATP MEK Type1 Type3 62 - 382 None None 3
Homo sapiens MP2K1_HUMAN 3MBLA 2.6 Inactive DFGin BLBplus out-out out-out ADP LSG Type1 Type3 62 - 381 None None 0
Homo sapiens MP2K1_HUMAN 3PP1A 2.7 Inactive DFGin BLBplus out-out out-out ATP IZG Type1 Type3 62 - 382 None None 0
Homo sapiens MP2K1_HUMAN 3EQBA 2.62 Inactive DFGin BLBplus out-out out-out ATP LUG Type1 Type3 62 - 382 None None 3
Homo sapiens MP2K1_HUMAN 4U80A 2.8 Inactive DFGin BLBplus out-out out-out ANP 3EX Type1 Type3 62 - 379 None None 3
Homo sapiens MP2K1_HUMAN 1S9JA 2.4 Inactive DFGin BLBplus out-out out-out ATP BBM Type1 Type3 62 - 382 None None 3
Homo sapiens MP2K1_HUMAN 3DY7A 2.7 Inactive DFGin BLBplus out-out out-out ATP 1CX Type1 Type3 62 - 364 None None 3
Homo sapiens MP2K1_HUMAN 3E8NA 2.5 Inactive DFGin BLBplus out-out out-out ATP VRA Type1 Type3 62 - 382 None None 1
Homo sapiens MP2K1_HUMAN 3VVHA 2.0 Inactive DFGin BLBplus out-out out-none ATP 4BM Type1 Type3 62 - 382 None None 5
Homo sapiens MP2K1_HUMAN 3VVHB 2.0 Inactive DFGin BLBplus out-out out-out ATP 4BM Type1 Type3 62 - 382 None None 0
Homo sapiens MP2K1_HUMAN 3VVHC 2.0 Inactive DFGin BLBplus out-out out-out ATP 4BM Type1 Type3 62 - 381 None None 0
Homo sapiens MP2K1_HUMAN 4ARKA 2.6 Inactive DFGin BLBplus out-out out-out ADP M3K Type1 Type3 62 - 382 None None 0
Homo sapiens MP2K1_HUMAN 4LMNA 2.8 Inactive DFGin BLBplus out-out out-out ANP EUI Type1 Type3 62 - 382 None None 0
Homo sapiens MP2K1_HUMAN 4MNEE 2.848 Inactive DFGin BLBplus out-out out-out ACP 573 Type1 Type3 62 - 379 None None 0
Homo sapiens MP2K1_HUMAN 3EQGA 2.5 Inactive DFGin BLBplus out-out out-out ADP 4BM Type1 Type3 39 - 381 S298N,S299K,Y300F None 0
Homo sapiens MP2K1_HUMAN 7UMBC 3.231 Inactive DFGin BLBplus out-out out-out ANP U9F Type1 Type3 41 - 381 None None 0
Homo sapiens MP2K1_HUMAN 6PP9B 2.59 Inactive DFGin BLBplus out-out out-out ANP LCJ Type1 Type3 38 - 383 S218A,S222A None 0
Homo sapiens MP2K1_HUMAN 7M0VB 3.16 Inactive DFGin BLBplus out-out out-out ANP EUI Type1 Type3 42 - 383 S218A,S222A None 0
Homo sapiens MP2K1_HUMAN 7M0WB 3.09 Inactive DFGin BLBplus out-out out-out ANP QOA Type1 Type3 42 - 383 S218A,S222A None 0
Homo sapiens MP2K1_HUMAN 7M0XB 2.47 Inactive DFGin BLBplus out-out out-out ANP 4BM Type1 Type3 40 - 383 S218A,S222A None 0
Homo sapiens MP2K1_HUMAN 7M0YB 3.45 Inactive DFGin BLBplus out-out out-out ANP QOM Type1 Type3 43 - 382 S218A,S222A None 0
Homo sapiens MP2K1_HUMAN 7M0ZB 3.12 Inactive DFGin BLBplus out-out out-out ANP CHU Type1 Type3 42 - 383 S218A,S222A None 0
Homo sapiens MP2K1_HUMAN 8DGTB 3.9 Inactive DFGin BLBplus out-out out-out AGS LCJ Type1 Type3 43 - 385 S218A,S222A None 0
Homo sapiens MP2K1_HUMAN 6NYBB 4.1 Inactive DFGin BLBplus out-out out-out ADP LCJ Type1 Type3 56 - 383 S218A,S222A None 0
Homo sapiens MP2K1_HUMAN 4MNEH 2.848 Inactive DFGin BLBplus out-out out-out ACP 573 573 Type1 Type3 Allosteric 66 - 380 None None 0
Homo sapiens MP2K1_HUMAN 7XLPA 2.1 Inactive DFGin BLBplus out-out out-out FZC Type1.5_Back 37 - 382 S298N,S299K,Y300K None 4
Homo sapiens MP2K1_HUMAN 7MFDB 3.66 Inactive DFGin BLBplus out-out out-out CHU Type3 52 - 383 None None 0
Homo sapiens MP2K1_HUMAN 4AN2A 2.5 Inactive DFGin BLBplus out-out out-out EUI ACP Type3 Type1 61 - 381 S218E,S222E,G328A None 0
Homo sapiens MP2K1_HUMAN 4ANBA 2.2 Inactive DFGin BLBplus out-out out-out YQY ACP Type3 Type1 61 - 381 S218E,S222E,G328A None 0
Homo sapiens MP2K1_HUMAN 2P55A 2.8 Inactive DFGin BLBplus out-out out-out MRA ATP Type3 Type1 62 - 382 None None 3
Homo sapiens MP2K1_HUMAN 4U7ZA 2.805 Inactive DFGin BLBplus out-out out-out 3EW ANP Type3 Type1 62 - 382 None None 1
Homo sapiens MP2K1_HUMAN 4U81A 2.701 Inactive DFGin BLBplus out-out out-out 3EY ANP Type3 Type1 62 - 382 None None 3
Homo sapiens MP2K1_HUMAN 3V01A 2.705 Inactive DFGin BLBplus out-out out-out 3V0 ATP Type3 Type1 62 - 382 None None 3
Homo sapiens MP2K1_HUMAN 3V04A 2.7 Inactive DFGin BLBplus out-out out-out V04 ATP Type3 Type1 62 - 382 None None 3
Homo sapiens MP2K1_HUMAN 3EQCA 1.8 Inactive DFGin BLBplus out-out out-out 3BM AGS Type3 Type1 39 - 382 S298N,S299K,Y300F None 3
Homo sapiens MP2K1_HUMAN 3EQHA 2.0 Inactive DFGin BLBplus out-out out-out 5BM ADP Type3 Type1 39 - 381 S298N,S299K,Y300F None 0
Homo sapiens MP2K1_HUMAN 7M0TB 3.19 Inactive DFGin BLBplus out-out out-out 3EW ANP Type3 Type1 42 - 383 S218A,S222A None 0
Homo sapiens MP2K1_HUMAN 7M0UB 3.09 Inactive DFGin BLBplus out-out out-out QO7 ANP Type3 Type1 43 - 385 S218A,S222A None 0
Homo sapiens MP2K1_HUMAN 5YT3B 2.9 Inactive DFGin None out-out out-out ANP Type1 40 - 382 S218D,S222D,T292A,S298A None 0
Homo sapiens MP2K1_HUMAN 5YT3D 2.9 Inactive DFGin None out-out out-out ANP Type1 39 - 382 S218D,S222D,T292A,S298A None 0
Homo sapiens MP2K1_HUMAN 5YT3A 2.9 Inactive DFGinter None out-out none-none ANP Type1 39 - 382 S218D,S222D,T292A,S298A None 14
Homo sapiens MP2K1_HUMAN 5HZEA 2.4 Inactive DFGout None out-out none-out E62 Type1 43 - 382 S298N,S299K,Y300F None 0
Homo sapiens MP2K1_HUMAN 7F2XA 2.007 Inactive None None out-out out-out ANP Type1 45 - 382 None None 0
Homo sapiens MP2K1_HUMAN 3W8QA 2.2 Inactive None None out-out out-out AGS Type1 39 - 382 T292A,S298A None 0
Homo sapiens MP2K1_HUMAN 6Q0TC 5.7 Inactive None None out-none out-out LCJ AGS Type1 Type1 43 - 379 S218A,S222A None 0
Homo sapiens MP2K1_HUMAN 6Q0JC 4.9 Inactive None None out-none out-out LCJ AGS Type1 Type1 43 - 379 S218A,S222A None 0
Homo sapiens MP2K1_HUMAN 6Q0JD 4.9 Inactive None None out-none out-out LCJ AGS Type1 Type1 43 - 379 S218A,S222A None 0
Oryctolagus cuniculus MP2K1_RABIT 5KKRC 3.509 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 41 - 381 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JUQC 3.22 Inactive DFGin BLBplus out-out out-out ADP Type1 40 - 381 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JUWC 2.88 Inactive DFGin BLBplus out-out out-out ANP Type1 40 - 382 None None 0
Oryctolagus cuniculus MP2K1_RABIT 2Y4IC 3.46 Inactive DFGin BLBplus out-out out-out ATP Type1 37 - 381 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JURC 2.82 Inactive DFGin BLBplus out-out out-out ANP QOM Type1 Type1 41 - 381 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JUTC 3.09 Inactive DFGin BLBplus out-out out-out ANP 3EW Type1 Type3 41 - 380 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JUUC 3.19 Inactive DFGin BLBplus out-out out-out ANP 4BM Type1 Type3 43 - 381 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JUVC 3.36 Inactive DFGin BLBplus out-out out-out ANP VKG Type1 Type3 41 - 381 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JUXC 3.34 Inactive DFGin BLBplus out-out out-out ANP QOM Type1 Type3 40 - 381 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JUYC 3.096 Inactive DFGin BLBplus out-out out-out ANP EUI Type1 Type3 40 - 382 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JUZC 3.21 Inactive DFGin BLBplus out-out out-out ANP 3EW Type1 Type3 40 - 382 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JV0C 3.63 Inactive DFGin BLBplus out-out out-out ANP 4BM Type1 Type3 40 - 382 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JV1C 3.62 Inactive DFGin BLBplus out-out out-out ANP VKG Type1 Type3 40 - 381 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JUSC 2.99 Inactive DFGin BLBplus out-out out-out VKD ANP Type3 Type1 41 - 381 None None 0

MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)

Group: STE
Total number of chains: 14
Spatial Dihedral Chains Representative
DFGin BLBplus 14 7JUWC
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Oryctolagus cuniculus MP2K1_RABIT 5KKRC 3.509 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 41 - 381 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JUQC 3.22 Inactive DFGin BLBplus out-out out-out ADP Type1 40 - 381 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JUWC 2.88 Inactive DFGin BLBplus out-out out-out ANP Type1 40 - 382 None None 0
Oryctolagus cuniculus MP2K1_RABIT 2Y4IC 3.46 Inactive DFGin BLBplus out-out out-out ATP Type1 37 - 381 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JURC 2.82 Inactive DFGin BLBplus out-out out-out ANP QOM Type1 Type1 41 - 381 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JUTC 3.09 Inactive DFGin BLBplus out-out out-out ANP 3EW Type1 Type3 41 - 380 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JUUC 3.19 Inactive DFGin BLBplus out-out out-out ANP 4BM Type1 Type3 43 - 381 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JUVC 3.36 Inactive DFGin BLBplus out-out out-out ANP VKG Type1 Type3 41 - 381 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JUXC 3.34 Inactive DFGin BLBplus out-out out-out ANP QOM Type1 Type3 40 - 381 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JUYC 3.096 Inactive DFGin BLBplus out-out out-out ANP EUI Type1 Type3 40 - 382 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JUZC 3.21 Inactive DFGin BLBplus out-out out-out ANP 3EW Type1 Type3 40 - 382 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JV0C 3.63 Inactive DFGin BLBplus out-out out-out ANP 4BM Type1 Type3 40 - 382 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JV1C 3.62 Inactive DFGin BLBplus out-out out-out ANP VKG Type1 Type3 40 - 381 None None 0
Oryctolagus cuniculus MP2K1_RABIT 7JUSC 2.99 Inactive DFGin BLBplus out-out out-out VKD ANP Type3 Type1 41 - 381 None None 0