IGF1R (Insulin-like growth factor 1 receptor)

Group: TYR
Uniprot: IGF1R_HUMAN
Domain boundary: 999 - 1268


Total number of chains: 73
Spatial Dihedral Chains Representative
DFGin BLAminus 3 AF-P08069-K1A
DFGin ABAminus 24 2ZM3A
DFGin BLBminus 1 3QQUA
DFGin None 30 5FXSA
DFGinter None 4 1P4OA
DFGout BBAminus 3 3LW0A
DFGout None 7 3O23A
None None 1 2OJ9A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
1K3AA 2.1 Inactive DFGin ABAminus in-out in-in ACP Type1 988 - 1286 None X1161,X1165,X1166 0
2ZM3A 2.5 Inactive DFGin ABAminus in-out in-in 575 Type1 981 - 1285 None X1161,X1165,X1166 0
2ZM3B 2.5 Inactive DFGin ABAminus in-out in-in 575 Type1 981 - 1285 None X1161,X1165,X1166 0
2ZM3C 2.5 Inactive DFGin ABAminus in-out in-in 575 Type1 981 - 1285 None X1161,X1165,X1166 0
2ZM3D 2.5 Inactive DFGin ABAminus in-out in-in 575 Type1 981 - 1285 None X1161,X1165,X1166 0
3LVPA 3.0 Inactive DFGin ABAminus in-out in-in PDR Type1 989 - 1286 None None 7
3LVPB 3.0 Inactive DFGin ABAminus in-out in-in PDR Type1 986 - 1285 None None 0
3LVPC 3.0 Inactive DFGin ABAminus in-out in-in PDR Type1 987 - 1286 None None 2
3F5PA 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1286 None X1161,X1165,X1166 0
3F5PB 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1286 None X1161,X1165,X1166 0
3F5PC 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1286 None X1161,X1165,X1166 0
3F5PD 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1286 None X1161,X1165,X1166 0
3F5PE 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1285 None X1161,X1165,X1166 0
3F5PF 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1285 None X1161,X1165,X1166 0
3F5PG 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1285 None X1161,X1165,X1166 0
3F5PH 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1286 None X1161,X1165,X1166 0
3F5PI 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1285 None X1161,X1165,X1166 0
3F5PJ 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1285 None X1161,X1165,X1166 0
3F5PK 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1285 None X1161,X1165,X1166 0
3F5PL 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1285 None X1161,X1165,X1166 0
3F5PM 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1285 None X1161,X1165,X1166 0
3F5PR 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1285 None X1161,X1165,X1166 0
3F5PS 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1286 None X1161,X1165,X1166 0
3F5PT 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1286 None X1161,X1165,X1166 0
AF-P08069-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 991 - 1276 None None 0
3QQUC 2.9 Inactive DFGin BLAminus in-in out-in 01P Type1 989 - 1285 None None 0
3LVPD 3.0 Active DFGin BLAminus in-in in-in PDR Type1 986 - 1285 None None 3
3QQUA 2.9 Inactive DFGin BLBminus in-out out-in 01P Type1 991 - 1285 None None 0
3QQUB 2.9 Inactive DFGin None in-out out-in 01P Type1 988 - 1286 None None 0
3QQUD 2.9 Inactive DFGin None in-out out-in 01P Type1 989 - 1285 None None 0
4D2RA 2.1 Inactive DFGin None out-out out-in DYK Type1 985 - 1286 None None 2
3NW5A 2.14 Inactive DFGin None out-out out-in LGX Type1 985 - 1286 None None 0
3NW6A 2.2 Inactive DFGin None out-out out-in LGW Type1 986 - 1286 None None 0
3NW7A 2.11 Inactive DFGin None in-out out-in LGV Type1 987 - 1286 None None 3
5FXQA 2.3 Inactive DFGin None out-out out-in GD5 Type1 980 - 1286 None None 3
5FXRA 2.4 Inactive DFGin None out-out out-in 8LN Type1 980 - 1283 None None 3
1JQHA 2.1 Inactive DFGin None in-out none-in ANP Type1 984 - 1286 E979G,Y980S None 7
1JQHB 2.1 Inactive DFGin None in-out none-in ANP Type1 984 - 1286 E979G,Y980S None 7
1JQHC 2.1 Inactive DFGin None in-out none-in ANP Type1 984 - 1286 E979G,Y980S None 7
3I81A 2.08 Inactive DFGin None out-out out-in EBI Type1 985 - 1286 None None 5
5FXSA 1.9 Inactive DFGin None out-none out-in OZN Type1 980 - 1286 None None 0
3D94A 2.3 Inactive DFGin None out-out out-in D94 Type1.5_Front 986 - 1285 None None 0
8PYIAAA 3.06 Inactive DFGin None out-out out-in IER Type1.5_Front 986 - 1286 None None 5
8PYIBBB 3.06 Inactive DFGin None out-out out-in IER Type1.5_Front 986 - 1285 None None 5
8PYICCC 3.06 Inactive DFGin None out-out out-in IER Type1.5_Front 987 - 1285 None None 5
8PYIDDD 3.06 Inactive DFGin None out-out out-in IER Type1.5_Front 987 - 1285 None None 4
8PYIEEE 3.06 Inactive DFGin None out-out out-in IER Type1.5_Front 987 - 1285 None None 6
8PYIFFF 3.06 Inactive DFGin None out-out out-in IER Type1.5_Front 987 - 1285 None None 3
8PYIGGG 3.06 Inactive DFGin None out-out out-in IER Type1.5_Front 987 - 1285 None None 6
8PYIHHH 3.06 Inactive DFGin None out-out out-in IER Type1.5_Front 987 - 1285 None None 5
5HZNA 2.2 Inactive DFGin None out-out out-in 66A Type1.5_Front 983 - 1286 E1097A,E1099A None 0
5HZNB 2.2 Inactive DFGin None out-out out-in 66A Type1.5_Front 983 - 1286 E1097A,E1099A None 0
5HZNC 2.2 Inactive DFGin None out-out out-in 66A Type1.5_Front 983 - 1286 E1097A,E1099A None 0
5HZND 2.2 Inactive DFGin None out-out out-in 66A Type1.5_Front 983 - 1286 E1097A,E1099A None 0
5HZNE 2.2 Inactive DFGin None out-out out-in 66A Type1.5_Front 983 - 1286 E1097A,E1099A None 0
5HZNF 2.2 Inactive DFGin None out-out out-in 66A Type1.5_Front 983 - 1286 E1097A,E1099A None 0
5HZNG 2.2 Inactive DFGin None out-out out-in 66A Type1.5_Front 983 - 1286 E1097A,E1099A None 0
5HZNH 2.2 Inactive DFGin None out-out out-in 66A Type1.5_Front 983 - 1285 E1097A,E1099A None 0
1M7NA 2.7 Inactive DFGinter None in-out out-in No_ligand No_ligand 982 - 1286 None None 0
1M7NB 2.7 Inactive DFGinter None in-out out-in No_ligand No_ligand 982 - 1286 None None 0
1P4OA 1.5 Inactive DFGinter None in-out out-in No_ligand No_ligand 978 - 1285 E1097A,E1099A None 0
1P4OB 1.5 Inactive DFGinter None in-out out-in No_ligand No_ligand 977 - 1290 E1097A,E1099A None 0
3LW0A 1.79 Inactive DFGout BBAminus in-out out-in CCX CCX Type3 Allosteric 983 - 1286 E1097A,E1099A None 3
3LW0B 1.79 Inactive DFGout BBAminus in-out out-in CCX CCX Type3 Allosteric 983 - 1286 E1097A,E1099A None 3
3LW0C 1.79 Inactive DFGout BBAminus in-out out-in CCX CCX Type3 Allosteric 983 - 1286 E1097A,E1099A None 3
3O23A 2.1 Inactive DFGout None out-out out-in MQY Type2 991 - 1283 Y987F None 0
8PYJAAA 2.702 Inactive DFGout None in-out out-in IEA Type2 986 - 1270 None None 0
8PYKAAA 2.23 Inactive DFGout None out-out out-in IC2 Type2 986 - 1270 None None 0
8PYLAAA 2.93 Inactive DFGout None out-out out-in IE0 Type2 986 - 1270 None None 0
8PYMAAA 2.652 Inactive DFGout None out-out out-in IED Type2 984 - 1270 None None 0
8PYNAAA 1.71 Inactive DFGout None in-out out-in ICV Type2 986 - 1270 None None 0
3LW0D 1.79 Inactive DFGout None in-out out-in CCX CCX Type3 Allosteric 983 - 1286 E1097A,E1099A None 3
2OJ9A 2.0 Inactive None None in-out out-in BMI Type1 984 - 1286 None None 0

IGF1R (Insulin-like growth factor 1 receptor)

Group: TYR
Total number of chains: 73
Spatial Dihedral Chains Representative
DFGin BLAminus 3 AF-P08069-K1A
DFGin ABAminus 24 2ZM3A
DFGin BLBminus 1 3QQUA
DFGin None 30 5FXSA
DFGinter None 4 1P4OA
DFGout BBAminus 3 3LW0A
DFGout None 7 3O23A
None None 1 2OJ9A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens IGF1R_HUMAN 1K3AA 2.1 Inactive DFGin ABAminus in-out in-in ACP Type1 988 - 1286 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN 2ZM3A 2.5 Inactive DFGin ABAminus in-out in-in 575 Type1 981 - 1285 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN 2ZM3B 2.5 Inactive DFGin ABAminus in-out in-in 575 Type1 981 - 1285 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN 2ZM3C 2.5 Inactive DFGin ABAminus in-out in-in 575 Type1 981 - 1285 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN 2ZM3D 2.5 Inactive DFGin ABAminus in-out in-in 575 Type1 981 - 1285 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN 3LVPA 3.0 Inactive DFGin ABAminus in-out in-in PDR Type1 989 - 1286 None None 7
Homo sapiens IGF1R_HUMAN 3LVPB 3.0 Inactive DFGin ABAminus in-out in-in PDR Type1 986 - 1285 None None 0
Homo sapiens IGF1R_HUMAN 3LVPC 3.0 Inactive DFGin ABAminus in-out in-in PDR Type1 987 - 1286 None None 2
Homo sapiens IGF1R_HUMAN 3F5PA 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1286 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN 3F5PB 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1286 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN 3F5PC 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1286 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN 3F5PD 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1286 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN 3F5PE 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1285 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN 3F5PF 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1285 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN 3F5PG 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1285 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN 3F5PH 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1286 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN 3F5PI 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1285 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN 3F5PJ 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1285 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN 3F5PK 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1285 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN 3F5PL 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1285 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN 3F5PM 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1285 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN 3F5PR 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1285 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN 3F5PS 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1286 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN 3F5PT 2.9 Inactive DFGin ABAminus out-out in-in 741 Type1.5_Front 981 - 1286 None X1161,X1165,X1166 0
Homo sapiens IGF1R_HUMAN AF-P08069-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 991 - 1276 None None 0
Homo sapiens IGF1R_HUMAN 3QQUC 2.9 Inactive DFGin BLAminus in-in out-in 01P Type1 989 - 1285 None None 0
Homo sapiens IGF1R_HUMAN 3LVPD 3.0 Active DFGin BLAminus in-in in-in PDR Type1 986 - 1285 None None 3
Homo sapiens IGF1R_HUMAN 3QQUA 2.9 Inactive DFGin BLBminus in-out out-in 01P Type1 991 - 1285 None None 0
Homo sapiens IGF1R_HUMAN 3QQUB 2.9 Inactive DFGin None in-out out-in 01P Type1 988 - 1286 None None 0
Homo sapiens IGF1R_HUMAN 3QQUD 2.9 Inactive DFGin None in-out out-in 01P Type1 989 - 1285 None None 0
Homo sapiens IGF1R_HUMAN 4D2RA 2.1 Inactive DFGin None out-out out-in DYK Type1 985 - 1286 None None 2
Homo sapiens IGF1R_HUMAN 3NW5A 2.14 Inactive DFGin None out-out out-in LGX Type1 985 - 1286 None None 0
Homo sapiens IGF1R_HUMAN 3NW6A 2.2 Inactive DFGin None out-out out-in LGW Type1 986 - 1286 None None 0
Homo sapiens IGF1R_HUMAN 3NW7A 2.11 Inactive DFGin None in-out out-in LGV Type1 987 - 1286 None None 3
Homo sapiens IGF1R_HUMAN 5FXQA 2.3 Inactive DFGin None out-out out-in GD5 Type1 980 - 1286 None None 3
Homo sapiens IGF1R_HUMAN 5FXRA 2.4 Inactive DFGin None out-out out-in 8LN Type1 980 - 1283 None None 3
Homo sapiens IGF1R_HUMAN 1JQHA 2.1 Inactive DFGin None in-out none-in ANP Type1 984 - 1286 E979G,Y980S None 7
Homo sapiens IGF1R_HUMAN 1JQHB 2.1 Inactive DFGin None in-out none-in ANP Type1 984 - 1286 E979G,Y980S None 7
Homo sapiens IGF1R_HUMAN 1JQHC 2.1 Inactive DFGin None in-out none-in ANP Type1 984 - 1286 E979G,Y980S None 7
Homo sapiens IGF1R_HUMAN 3I81A 2.08 Inactive DFGin None out-out out-in EBI Type1 985 - 1286 None None 5
Homo sapiens IGF1R_HUMAN 5FXSA 1.9 Inactive DFGin None out-none out-in OZN Type1 980 - 1286 None None 0
Homo sapiens IGF1R_HUMAN 3D94A 2.3 Inactive DFGin None out-out out-in D94 Type1.5_Front 986 - 1285 None None 0
Homo sapiens IGF1R_HUMAN 8PYIAAA 3.06 Inactive DFGin None out-out out-in IER Type1.5_Front 986 - 1286 None None 5
Homo sapiens IGF1R_HUMAN 8PYIBBB 3.06 Inactive DFGin None out-out out-in IER Type1.5_Front 986 - 1285 None None 5
Homo sapiens IGF1R_HUMAN 8PYICCC 3.06 Inactive DFGin None out-out out-in IER Type1.5_Front 987 - 1285 None None 5
Homo sapiens IGF1R_HUMAN 8PYIDDD 3.06 Inactive DFGin None out-out out-in IER Type1.5_Front 987 - 1285 None None 4
Homo sapiens IGF1R_HUMAN 8PYIEEE 3.06 Inactive DFGin None out-out out-in IER Type1.5_Front 987 - 1285 None None 6
Homo sapiens IGF1R_HUMAN 8PYIFFF 3.06 Inactive DFGin None out-out out-in IER Type1.5_Front 987 - 1285 None None 3
Homo sapiens IGF1R_HUMAN 8PYIGGG 3.06 Inactive DFGin None out-out out-in IER Type1.5_Front 987 - 1285 None None 6
Homo sapiens IGF1R_HUMAN 8PYIHHH 3.06 Inactive DFGin None out-out out-in IER Type1.5_Front 987 - 1285 None None 5
Homo sapiens IGF1R_HUMAN 5HZNA 2.2 Inactive DFGin None out-out out-in 66A Type1.5_Front 983 - 1286 E1097A,E1099A None 0
Homo sapiens IGF1R_HUMAN 5HZNB 2.2 Inactive DFGin None out-out out-in 66A Type1.5_Front 983 - 1286 E1097A,E1099A None 0
Homo sapiens IGF1R_HUMAN 5HZNC 2.2 Inactive DFGin None out-out out-in 66A Type1.5_Front 983 - 1286 E1097A,E1099A None 0
Homo sapiens IGF1R_HUMAN 5HZND 2.2 Inactive DFGin None out-out out-in 66A Type1.5_Front 983 - 1286 E1097A,E1099A None 0
Homo sapiens IGF1R_HUMAN 5HZNE 2.2 Inactive DFGin None out-out out-in 66A Type1.5_Front 983 - 1286 E1097A,E1099A None 0
Homo sapiens IGF1R_HUMAN 5HZNF 2.2 Inactive DFGin None out-out out-in 66A Type1.5_Front 983 - 1286 E1097A,E1099A None 0
Homo sapiens IGF1R_HUMAN 5HZNG 2.2 Inactive DFGin None out-out out-in 66A Type1.5_Front 983 - 1286 E1097A,E1099A None 0
Homo sapiens IGF1R_HUMAN 5HZNH 2.2 Inactive DFGin None out-out out-in 66A Type1.5_Front 983 - 1285 E1097A,E1099A None 0
Homo sapiens IGF1R_HUMAN 1M7NA 2.7 Inactive DFGinter None in-out out-in No_ligand No_ligand 982 - 1286 None None 0
Homo sapiens IGF1R_HUMAN 1M7NB 2.7 Inactive DFGinter None in-out out-in No_ligand No_ligand 982 - 1286 None None 0
Homo sapiens IGF1R_HUMAN 1P4OA 1.5 Inactive DFGinter None in-out out-in No_ligand No_ligand 978 - 1285 E1097A,E1099A None 0
Homo sapiens IGF1R_HUMAN 1P4OB 1.5 Inactive DFGinter None in-out out-in No_ligand No_ligand 977 - 1290 E1097A,E1099A None 0
Homo sapiens IGF1R_HUMAN 3LW0A 1.79 Inactive DFGout BBAminus in-out out-in CCX CCX Type3 Allosteric 983 - 1286 E1097A,E1099A None 3
Homo sapiens IGF1R_HUMAN 3LW0B 1.79 Inactive DFGout BBAminus in-out out-in CCX CCX Type3 Allosteric 983 - 1286 E1097A,E1099A None 3
Homo sapiens IGF1R_HUMAN 3LW0C 1.79 Inactive DFGout BBAminus in-out out-in CCX CCX Type3 Allosteric 983 - 1286 E1097A,E1099A None 3
Homo sapiens IGF1R_HUMAN 3O23A 2.1 Inactive DFGout None out-out out-in MQY Type2 991 - 1283 Y987F None 0
Homo sapiens IGF1R_HUMAN 8PYJAAA 2.702 Inactive DFGout None in-out out-in IEA Type2 986 - 1270 None None 0
Homo sapiens IGF1R_HUMAN 8PYKAAA 2.23 Inactive DFGout None out-out out-in IC2 Type2 986 - 1270 None None 0
Homo sapiens IGF1R_HUMAN 8PYLAAA 2.93 Inactive DFGout None out-out out-in IE0 Type2 986 - 1270 None None 0
Homo sapiens IGF1R_HUMAN 8PYMAAA 2.652 Inactive DFGout None out-out out-in IED Type2 984 - 1270 None None 0
Homo sapiens IGF1R_HUMAN 8PYNAAA 1.71 Inactive DFGout None in-out out-in ICV Type2 986 - 1270 None None 0
Homo sapiens IGF1R_HUMAN 3LW0D 1.79 Inactive DFGout None in-out out-in CCX CCX Type3 Allosteric 983 - 1286 E1097A,E1099A None 3
Homo sapiens IGF1R_HUMAN 2OJ9A 2.0 Inactive None None in-out out-in BMI Type1 984 - 1286 None None 0

IGF1R (Insulin-like growth factor 1 receptor)

No non-human structures known.