MAPK10 (Mitogen-activated protein kinase 10)

Group: CMGC
Uniprot: MK10_HUMAN
Domain boundary: 64 - 359


Total number of chains: 72
Spatial Dihedral Chains Representative
DFGin BLAminus 2 AF-P53779-K1A
DFGin ABAminus 64 7ORFA
DFGin BLBplus 3 4H36A
DFGin None 3 1PMVA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
4Z9LA 2.1 Inactive DFGin ABAminus out-out none-out ANP 880 Allosteric Type1 45 - 400 None None 10
4KKGA 2.4 Inactive DFGin ABAminus in-in out-out No_ligand No_ligand 45 - 400 None None 3
3FI2A 2.28 Inactive DFGin ABAminus out-out out-out JK1 Type1 45 - 400 None None 12
3FV8A 2.28 Inactive DFGin ABAminus in-in out-out JK3 Type1 46 - 400 None None 12
2B1PA 1.9 Inactive DFGin ABAminus out-out none-none AIZ Type1 46 - 400 None None 15
2R9SA 2.4 Inactive DFGin ABAminus in-in none-none 255 Type1 46 - 401 None None 15
2R9SB 2.4 Inactive DFGin ABAminus in-in none-none 255 Type1 46 - 401 None None 15
2EXCX 2.75 Inactive DFGin ABAminus out-out none-out JNK Type1 45 - 400 None None 13
3OY1A 1.7 Inactive DFGin ABAminus out-out none-out 589 Type1 46 - 400 None None 14
3RTPA 2.4 Inactive DFGin ABAminus in-out none-none 34I Type1 46 - 400 None None 15
2O2UA 2.45 Inactive DFGin ABAminus out-out none-out 738 Type1 46 - 400 None None 13
2WAJA 2.4 Inactive DFGin ABAminus out-out out-out SNB Type1 46 - 400 None None 3
2ZDTA 2.0 Inactive DFGin ABAminus in-in none-out 46C Type1 45 - 400 None None 5
2ZDUA 2.5 Inactive DFGin ABAminus in-out none-out 446 Type1 46 - 400 None None 13
3FI3A 2.2 Inactive DFGin ABAminus out-out out-out JK2 Type1 45 - 401 None None 12
3KVXA 2.4 Inactive DFGin ABAminus in-out out-out FMY Type1 46 - 401 None None 12
3V6RA 2.6 Inactive DFGin ABAminus in-in out-out CQQ Type1 45 - 401 None None 4
3V6RB 2.6 Inactive DFGin ABAminus in-in out-out CQQ Type1 45 - 401 None None 6
3V6SA 2.97 Inactive DFGin ABAminus in-in out-out 0F0 Type1 45 - 401 None None 5
3V6SB 2.97 Inactive DFGin ABAminus in-in none-out 0F0 Type1 45 - 401 None None 13
8WGFA 1.85 Inactive DFGin ABAminus in-out out-out ANP Type1 44 - 400 None None 4
1PMNA 2.2 Inactive DFGin ABAminus out-out none-out 984 Type1 45 - 400 None None 5
1PMUA 2.7 Inactive DFGin ABAminus in-out out-out 9HP Type1 45 - 400 None None 8
7ORFA 1.7 Inactive DFGin ABAminus out-out out-out 0G3 Type1 45 - 401 None None 0
2OK1A 2.4 Inactive DFGin ABAminus out-out none-out 33A Type1 46 - 400 None None 13
2P33A 2.4 Inactive DFGin ABAminus in-in none-out J07 Type1 45 - 400 None None 5
3CGFA 3.0 Inactive DFGin ABAminus in-out none-out JNF Type1 45 - 400 None None 5
3CGOA 3.0 Inactive DFGin ABAminus in-in none-out JNO Type1 45 - 400 None None 5
3G90X 2.4 Inactive DFGin ABAminus in-in none-out J72 Type1 46 - 400 None None 5
3G9LX 2.2 Inactive DFGin ABAminus in-out none-out J67 Type1 46 - 400 None None 9
3G9NA 2.8 Inactive DFGin ABAminus in-in none-out J88 Type1 45 - 400 None None 5
4KKEA 2.2 Inactive DFGin ABAminus in-out out-out AMP Type1 45 - 400 None None 2
4KKHA 2.0 Inactive DFGin ABAminus out-out out-out 1RQ Type1 45 - 400 None None 2
4W4VA 2.01 Inactive DFGin ABAminus out-out out-out 3H8 Type1 45 - 400 None None 0
4W4WA 1.9 Inactive DFGin ABAminus out-out out-out 3HJ Type1 45 - 400 None None 2
4W4XA 2.65 Inactive DFGin ABAminus out-out out-out 3HN Type1 45 - 400 None None 0
4W4YA 2.3 Inactive DFGin ABAminus out-out out-out 3HQ Type1 45 - 400 None None 0
4Y46A 2.04 Inactive DFGin ABAminus in-in out-out 4F2 Type1 45 - 400 None None 2
4Y5HA 2.055 Inactive DFGin ABAminus in-in out-out 519 Type1 45 - 400 None None 2
4X21A 1.95 Inactive DFGin ABAminus in-in none-out 3WH Type1 46 - 400 None None 14
4X21B 1.95 Inactive DFGin ABAminus in-in none-out 3WH Type1 47 - 400 None None 13
6EKDA 2.1 Inactive DFGin ABAminus in-in none-out B9K Type1 46 - 400 None None 14
6EMHC 1.76 Inactive DFGin ABAminus in-in out-out BGE Type1 46 - 400 None None 10
6EMHD 1.76 Inactive DFGin ABAminus in-in out-none BGE Type1 46 - 400 None None 11
6EQ9B 1.83 Inactive DFGin ABAminus in-in none-out ACP Type1 47 - 400 None None 14
4WHZA 1.79 Inactive DFGin ABAminus out-out none-out 3NL Type1 45 - 400 None None 5
1JNKA 2.3 Inactive DFGin ABAminus in-out none-out ANP Type1 45 - 400 None None 5
3TTIA 2.2 Inactive DFGin ABAminus out-out none-out KBI Type1 46 - 400 None None 5
3TTJA 2.1 Inactive DFGin ABAminus out-out none-out JBI Type1 46 - 400 None None 9
7KSIA 1.726 Inactive DFGin ABAminus out-out none-out X3S Type1 45 - 400 None None 5
7KSJA 2.06 Inactive DFGin ABAminus out-out none-out X3Y Type1 45 - 400 None None 5
7KSKA 1.84 Inactive DFGin ABAminus out-out none-out X3V Type1 45 - 400 None None 6
7S1NA 2.11 Inactive DFGin ABAminus out-out none-out 86C Type1 45 - 400 None None 5
7YL1A 2.48 Inactive DFGin ABAminus in-in out-out J6F Type1 45 - 400 None None 2
8ENJA 2.81 Inactive DFGin ABAminus in-in none-out WNK Type1 45 - 400 None None 5
8BZPA 1.86 Inactive DFGin ABAminus in-none out-out SWM C15 Type1 Allosteric 46 - 400 None None 5
6EMHA 1.76 Inactive DFGin ABAminus in-in out-out BGE C15 Type1 Allosteric 46 - 400 None None 5
6EMHB 1.76 Inactive DFGin ABAminus in-in out-out BGE C15 Type1 Allosteric 46 - 400 None None 5
6EQ9A 1.83 Inactive DFGin ABAminus in-out out-out ACP C15 Type1 Allosteric 46 - 400 None None 5
7OREA 2.18 Inactive DFGin ABAminus out-out out-out 0EI 0EI Type1 Type1 44 - 402 None None 0
8BZPB 1.86 Inactive DFGin ABAminus in-out none-none SWM C15 C15 Type1 Type1 Allosteric 47 - 400 None None 15
2O0UA 2.1 Inactive DFGin ABAminus out-out out-out C0M Type1.5_Back 46 - 400 None None 5
3DA6A 2.0 Inactive DFGin ABAminus out-out out-out BZ9 Type1.5_Front 46 - 401 None None 10
4U79A 2.23 Inactive DFGin ABAminus out-out out-out 3EL Type1.5_Front 44 - 400 None None 11
AF-P53779-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 56 - 367 None None 0
4H39A 1.992 None DFGin BLAminus in-in none-out No_ligand No_ligand 45 - 400 None None 11
4H36A 3.0 Inactive DFGin BLBplus in-in out-out No_ligand No_ligand 45 - 400 None None 0
4H3BA 2.08 Inactive DFGin BLBplus in-in out-out No_ligand No_ligand 45 - 400 None None 0
4H3BC 2.08 Inactive DFGin BLBplus in-in out-out No_ligand No_ligand 45 - 400 None None 0
3OXIA 2.2 Inactive DFGin None in-in none-out SYY Type1 46 - 400 None None 15
3PTGA 2.43 Inactive DFGin None in-in none-out 932 Type1 46 - 401 None None 13
1PMVA 2.5 Inactive DFGin None out-out none-out 537 Type1 45 - 400 None None 5

MAPK10 (Mitogen-activated protein kinase 10)

Group: CMGC
Total number of chains: 72
Spatial Dihedral Chains Representative
DFGin BLAminus 2 AF-P53779-K1A
DFGin ABAminus 64 7ORFA
DFGin BLBplus 3 4H36A
DFGin None 3 1PMVA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens MK10_HUMAN 4Z9LA 2.1 Inactive DFGin ABAminus out-out none-out ANP 880 Allosteric Type1 45 - 400 None None 10
Homo sapiens MK10_HUMAN 4KKGA 2.4 Inactive DFGin ABAminus in-in out-out No_ligand No_ligand 45 - 400 None None 3
Homo sapiens MK10_HUMAN 3FI2A 2.28 Inactive DFGin ABAminus out-out out-out JK1 Type1 45 - 400 None None 12
Homo sapiens MK10_HUMAN 3FV8A 2.28 Inactive DFGin ABAminus in-in out-out JK3 Type1 46 - 400 None None 12
Homo sapiens MK10_HUMAN 2B1PA 1.9 Inactive DFGin ABAminus out-out none-none AIZ Type1 46 - 400 None None 15
Homo sapiens MK10_HUMAN 2R9SA 2.4 Inactive DFGin ABAminus in-in none-none 255 Type1 46 - 401 None None 15
Homo sapiens MK10_HUMAN 2R9SB 2.4 Inactive DFGin ABAminus in-in none-none 255 Type1 46 - 401 None None 15
Homo sapiens MK10_HUMAN 2EXCX 2.75 Inactive DFGin ABAminus out-out none-out JNK Type1 45 - 400 None None 13
Homo sapiens MK10_HUMAN 3OY1A 1.7 Inactive DFGin ABAminus out-out none-out 589 Type1 46 - 400 None None 14
Homo sapiens MK10_HUMAN 3RTPA 2.4 Inactive DFGin ABAminus in-out none-none 34I Type1 46 - 400 None None 15
Homo sapiens MK10_HUMAN 2O2UA 2.45 Inactive DFGin ABAminus out-out none-out 738 Type1 46 - 400 None None 13
Homo sapiens MK10_HUMAN 2WAJA 2.4 Inactive DFGin ABAminus out-out out-out SNB Type1 46 - 400 None None 3
Homo sapiens MK10_HUMAN 2ZDTA 2.0 Inactive DFGin ABAminus in-in none-out 46C Type1 45 - 400 None None 5
Homo sapiens MK10_HUMAN 2ZDUA 2.5 Inactive DFGin ABAminus in-out none-out 446 Type1 46 - 400 None None 13
Homo sapiens MK10_HUMAN 3FI3A 2.2 Inactive DFGin ABAminus out-out out-out JK2 Type1 45 - 401 None None 12
Homo sapiens MK10_HUMAN 3KVXA 2.4 Inactive DFGin ABAminus in-out out-out FMY Type1 46 - 401 None None 12
Homo sapiens MK10_HUMAN 3V6RA 2.6 Inactive DFGin ABAminus in-in out-out CQQ Type1 45 - 401 None None 4
Homo sapiens MK10_HUMAN 3V6RB 2.6 Inactive DFGin ABAminus in-in out-out CQQ Type1 45 - 401 None None 6
Homo sapiens MK10_HUMAN 3V6SA 2.97 Inactive DFGin ABAminus in-in out-out 0F0 Type1 45 - 401 None None 5
Homo sapiens MK10_HUMAN 3V6SB 2.97 Inactive DFGin ABAminus in-in none-out 0F0 Type1 45 - 401 None None 13
Homo sapiens MK10_HUMAN 8WGFA 1.85 Inactive DFGin ABAminus in-out out-out ANP Type1 44 - 400 None None 4
Homo sapiens MK10_HUMAN 1PMNA 2.2 Inactive DFGin ABAminus out-out none-out 984 Type1 45 - 400 None None 5
Homo sapiens MK10_HUMAN 1PMUA 2.7 Inactive DFGin ABAminus in-out out-out 9HP Type1 45 - 400 None None 8
Homo sapiens MK10_HUMAN 7ORFA 1.7 Inactive DFGin ABAminus out-out out-out 0G3 Type1 45 - 401 None None 0
Homo sapiens MK10_HUMAN 2OK1A 2.4 Inactive DFGin ABAminus out-out none-out 33A Type1 46 - 400 None None 13
Homo sapiens MK10_HUMAN 2P33A 2.4 Inactive DFGin ABAminus in-in none-out J07 Type1 45 - 400 None None 5
Homo sapiens MK10_HUMAN 3CGFA 3.0 Inactive DFGin ABAminus in-out none-out JNF Type1 45 - 400 None None 5
Homo sapiens MK10_HUMAN 3CGOA 3.0 Inactive DFGin ABAminus in-in none-out JNO Type1 45 - 400 None None 5
Homo sapiens MK10_HUMAN 3G90X 2.4 Inactive DFGin ABAminus in-in none-out J72 Type1 46 - 400 None None 5
Homo sapiens MK10_HUMAN 3G9LX 2.2 Inactive DFGin ABAminus in-out none-out J67 Type1 46 - 400 None None 9
Homo sapiens MK10_HUMAN 3G9NA 2.8 Inactive DFGin ABAminus in-in none-out J88 Type1 45 - 400 None None 5
Homo sapiens MK10_HUMAN 4KKEA 2.2 Inactive DFGin ABAminus in-out out-out AMP Type1 45 - 400 None None 2
Homo sapiens MK10_HUMAN 4KKHA 2.0 Inactive DFGin ABAminus out-out out-out 1RQ Type1 45 - 400 None None 2
Homo sapiens MK10_HUMAN 4W4VA 2.01 Inactive DFGin ABAminus out-out out-out 3H8 Type1 45 - 400 None None 0
Homo sapiens MK10_HUMAN 4W4WA 1.9 Inactive DFGin ABAminus out-out out-out 3HJ Type1 45 - 400 None None 2
Homo sapiens MK10_HUMAN 4W4XA 2.65 Inactive DFGin ABAminus out-out out-out 3HN Type1 45 - 400 None None 0
Homo sapiens MK10_HUMAN 4W4YA 2.3 Inactive DFGin ABAminus out-out out-out 3HQ Type1 45 - 400 None None 0
Homo sapiens MK10_HUMAN 4Y46A 2.04 Inactive DFGin ABAminus in-in out-out 4F2 Type1 45 - 400 None None 2
Homo sapiens MK10_HUMAN 4Y5HA 2.055 Inactive DFGin ABAminus in-in out-out 519 Type1 45 - 400 None None 2
Homo sapiens MK10_HUMAN 4X21A 1.95 Inactive DFGin ABAminus in-in none-out 3WH Type1 46 - 400 None None 14
Homo sapiens MK10_HUMAN 4X21B 1.95 Inactive DFGin ABAminus in-in none-out 3WH Type1 47 - 400 None None 13
Homo sapiens MK10_HUMAN 6EKDA 2.1 Inactive DFGin ABAminus in-in none-out B9K Type1 46 - 400 None None 14
Homo sapiens MK10_HUMAN 6EMHC 1.76 Inactive DFGin ABAminus in-in out-out BGE Type1 46 - 400 None None 10
Homo sapiens MK10_HUMAN 6EMHD 1.76 Inactive DFGin ABAminus in-in out-none BGE Type1 46 - 400 None None 11
Homo sapiens MK10_HUMAN 6EQ9B 1.83 Inactive DFGin ABAminus in-in none-out ACP Type1 47 - 400 None None 14
Homo sapiens MK10_HUMAN 4WHZA 1.79 Inactive DFGin ABAminus out-out none-out 3NL Type1 45 - 400 None None 5
Homo sapiens MK10_HUMAN 1JNKA 2.3 Inactive DFGin ABAminus in-out none-out ANP Type1 45 - 400 None None 5
Homo sapiens MK10_HUMAN 3TTIA 2.2 Inactive DFGin ABAminus out-out none-out KBI Type1 46 - 400 None None 5
Homo sapiens MK10_HUMAN 3TTJA 2.1 Inactive DFGin ABAminus out-out none-out JBI Type1 46 - 400 None None 9
Homo sapiens MK10_HUMAN 7KSIA 1.726 Inactive DFGin ABAminus out-out none-out X3S Type1 45 - 400 None None 5
Homo sapiens MK10_HUMAN 7KSJA 2.06 Inactive DFGin ABAminus out-out none-out X3Y Type1 45 - 400 None None 5
Homo sapiens MK10_HUMAN 7KSKA 1.84 Inactive DFGin ABAminus out-out none-out X3V Type1 45 - 400 None None 6
Homo sapiens MK10_HUMAN 7S1NA 2.11 Inactive DFGin ABAminus out-out none-out 86C Type1 45 - 400 None None 5
Homo sapiens MK10_HUMAN 7YL1A 2.48 Inactive DFGin ABAminus in-in out-out J6F Type1 45 - 400 None None 2
Homo sapiens MK10_HUMAN 8ENJA 2.81 Inactive DFGin ABAminus in-in none-out WNK Type1 45 - 400 None None 5
Homo sapiens MK10_HUMAN 8BZPA 1.86 Inactive DFGin ABAminus in-none out-out SWM C15 Type1 Allosteric 46 - 400 None None 5
Homo sapiens MK10_HUMAN 6EMHA 1.76 Inactive DFGin ABAminus in-in out-out BGE C15 Type1 Allosteric 46 - 400 None None 5
Homo sapiens MK10_HUMAN 6EMHB 1.76 Inactive DFGin ABAminus in-in out-out BGE C15 Type1 Allosteric 46 - 400 None None 5
Homo sapiens MK10_HUMAN 6EQ9A 1.83 Inactive DFGin ABAminus in-out out-out ACP C15 Type1 Allosteric 46 - 400 None None 5
Homo sapiens MK10_HUMAN 7OREA 2.18 Inactive DFGin ABAminus out-out out-out 0EI 0EI Type1 Type1 44 - 402 None None 0
Homo sapiens MK10_HUMAN 8BZPB 1.86 Inactive DFGin ABAminus in-out none-none SWM C15 C15 Type1 Type1 Allosteric 47 - 400 None None 15
Homo sapiens MK10_HUMAN 2O0UA 2.1 Inactive DFGin ABAminus out-out out-out C0M Type1.5_Back 46 - 400 None None 5
Homo sapiens MK10_HUMAN 3DA6A 2.0 Inactive DFGin ABAminus out-out out-out BZ9 Type1.5_Front 46 - 401 None None 10
Homo sapiens MK10_HUMAN 4U79A 2.23 Inactive DFGin ABAminus out-out out-out 3EL Type1.5_Front 44 - 400 None None 11
Homo sapiens MK10_HUMAN AF-P53779-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 56 - 367 None None 0
Homo sapiens MK10_HUMAN 4H39A 1.992 None DFGin BLAminus in-in none-out No_ligand No_ligand 45 - 400 None None 11
Homo sapiens MK10_HUMAN 4H36A 3.0 Inactive DFGin BLBplus in-in out-out No_ligand No_ligand 45 - 400 None None 0
Homo sapiens MK10_HUMAN 4H3BA 2.08 Inactive DFGin BLBplus in-in out-out No_ligand No_ligand 45 - 400 None None 0
Homo sapiens MK10_HUMAN 4H3BC 2.08 Inactive DFGin BLBplus in-in out-out No_ligand No_ligand 45 - 400 None None 0
Homo sapiens MK10_HUMAN 3OXIA 2.2 Inactive DFGin None in-in none-out SYY Type1 46 - 400 None None 15
Homo sapiens MK10_HUMAN 3PTGA 2.43 Inactive DFGin None in-in none-out 932 Type1 46 - 401 None None 13
Homo sapiens MK10_HUMAN 1PMVA 2.5 Inactive DFGin None out-out none-out 537 Type1 45 - 400 None None 5

MAPK10 (Mitogen-activated protein kinase 10)

No non-human structures known.