TNK2 (Activated CDC42 kinase 1)

Group: TYR
Uniprot: ACK1_HUMAN
Domain boundary: 126 - 387


Total number of chains: 31
Spatial Dihedral Chains Representative
DFGin BLAminus 8 AF-Q07912-K1A
DFGin ABAminus 16 4EWHA
DFGin BLBplus 4 4HZSA
DFGin None 1 8HMTD
DFGout None 2 5ZXBB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
4HZRA 1.31 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 117 - 389 None None 0
4HZRB 1.31 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 118 - 389 None None 0
1U46A 2.0 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 117 - 389 None None 6
4EWHA 2.5 Inactive DFGin ABAminus in-in in-in T77 Type1 117 - 391 None X284 0
4EWHB 2.5 Inactive DFGin ABAminus in-in in-in T77 Type1 117 - 390 None X284 0
7KP6A 1.79 Inactive DFGin ABAminus in-out in-in WTP Type1 117 - 391 None None 0
7KP6B 1.79 Inactive DFGin ABAminus in-in in-in WTP Type1 117 - 391 None None 4
6VQMA 2.87 Inactive DFGin ABAminus in-in in-in R7P Type1 117 - 390 None None 0
1U54A 2.8 Inactive DFGin ABAminus in-in in-in ACP Type1 115 - 390 None X284 1
8FE9A 3.2 Inactive DFGin ABAminus in-out in-in R9B Type1 117 - 391 K161Q None 0
4ID7A 3.0 Inactive DFGin ABAminus out-out in-in 1G0 Type1.5_Back 117 - 389 None None 0
8HMTA 3.17 Inactive DFGin ABAminus in-out in-in LWX Type1.5_Back 117 - 389 None None 0
8HMTB 3.17 Inactive DFGin ABAminus in-in in-in LWX Type1.5_Back 117 - 388 None None 0
8HMTC 3.17 Inactive DFGin ABAminus in-out in-in LWX Type1.5_Back 117 - 389 None None 0
3EQRA 2.0 Inactive DFGin ABAminus in-in in-in T74 Type1.5_Back 117 - 392 None None 0
3EQRB 2.0 Inactive DFGin ABAminus in-in in-in T74 Type1.5_Back 117 - 390 None None 3
AF-Q07912-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 118 - 395 None None 0
1U46B 2.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 117 - 390 None None 0
3EQPA 2.3 Active DFGin BLAminus in-in in-in T95 Type1 117 - 390 None None 0
3EQPB 2.3 Active DFGin BLAminus in-in in-in T95 Type1 117 - 392 None None 0
6VQMB 2.87 Active DFGin BLAminus in-in in-in R7P Type1 117 - 392 None None 0
1U4DA 2.1 Active DFGin BLAminus in-in in-in DBQ Type1 117 - 389 None None 7
1U4DB 2.1 Active DFGin BLAminus in-in in-in DBQ Type1 117 - 390 None None 0
1U54B 2.8 Active DFGin BLAminus in-in in-in ACP Type1 117 - 388 None None 0
4HZSA 3.23 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 115 - 446 None None 13
4HZSB 3.23 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 115 - 446 None None 13
4HZSC 3.23 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 115 - 446 None None 13
4HZSD 3.23 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 115 - 446 None None 13
8HMTD 3.17 Inactive DFGin None in-out in-in LWX Type1.5_Back 117 - 389 None None 0
5ZXBA 2.198 Inactive DFGout None in-in none-none 9KO Type2 117 - 389 None None 21
5ZXBB 2.198 Inactive DFGout None in-in none-none 9KO Type2 117 - 389 None None 21

TNK2 (Activated CDC42 kinase 1)

Group: TYR
Total number of chains: 31
Spatial Dihedral Chains Representative
DFGin BLAminus 8 AF-Q07912-K1A
DFGin ABAminus 16 4EWHA
DFGin BLBplus 4 4HZSA
DFGin None 1 8HMTD
DFGout None 2 5ZXBB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens ACK1_HUMAN 4HZRA 1.31 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 117 - 389 None None 0
Homo sapiens ACK1_HUMAN 4HZRB 1.31 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 118 - 389 None None 0
Homo sapiens ACK1_HUMAN 1U46A 2.0 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 117 - 389 None None 6
Homo sapiens ACK1_HUMAN 4EWHA 2.5 Inactive DFGin ABAminus in-in in-in T77 Type1 117 - 391 None X284 0
Homo sapiens ACK1_HUMAN 4EWHB 2.5 Inactive DFGin ABAminus in-in in-in T77 Type1 117 - 390 None X284 0
Homo sapiens ACK1_HUMAN 7KP6A 1.79 Inactive DFGin ABAminus in-out in-in WTP Type1 117 - 391 None None 0
Homo sapiens ACK1_HUMAN 7KP6B 1.79 Inactive DFGin ABAminus in-in in-in WTP Type1 117 - 391 None None 4
Homo sapiens ACK1_HUMAN 6VQMA 2.87 Inactive DFGin ABAminus in-in in-in R7P Type1 117 - 390 None None 0
Homo sapiens ACK1_HUMAN 1U54A 2.8 Inactive DFGin ABAminus in-in in-in ACP Type1 115 - 390 None X284 1
Homo sapiens ACK1_HUMAN 8FE9A 3.2 Inactive DFGin ABAminus in-out in-in R9B Type1 117 - 391 K161Q None 0
Homo sapiens ACK1_HUMAN 4ID7A 3.0 Inactive DFGin ABAminus out-out in-in 1G0 Type1.5_Back 117 - 389 None None 0
Homo sapiens ACK1_HUMAN 8HMTA 3.17 Inactive DFGin ABAminus in-out in-in LWX Type1.5_Back 117 - 389 None None 0
Homo sapiens ACK1_HUMAN 8HMTB 3.17 Inactive DFGin ABAminus in-in in-in LWX Type1.5_Back 117 - 388 None None 0
Homo sapiens ACK1_HUMAN 8HMTC 3.17 Inactive DFGin ABAminus in-out in-in LWX Type1.5_Back 117 - 389 None None 0
Homo sapiens ACK1_HUMAN 3EQRA 2.0 Inactive DFGin ABAminus in-in in-in T74 Type1.5_Back 117 - 392 None None 0
Homo sapiens ACK1_HUMAN 3EQRB 2.0 Inactive DFGin ABAminus in-in in-in T74 Type1.5_Back 117 - 390 None None 3
Homo sapiens ACK1_HUMAN AF-Q07912-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 118 - 395 None None 0
Homo sapiens ACK1_HUMAN 1U46B 2.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 117 - 390 None None 0
Homo sapiens ACK1_HUMAN 3EQPA 2.3 Active DFGin BLAminus in-in in-in T95 Type1 117 - 390 None None 0
Homo sapiens ACK1_HUMAN 3EQPB 2.3 Active DFGin BLAminus in-in in-in T95 Type1 117 - 392 None None 0
Homo sapiens ACK1_HUMAN 6VQMB 2.87 Active DFGin BLAminus in-in in-in R7P Type1 117 - 392 None None 0
Homo sapiens ACK1_HUMAN 1U4DA 2.1 Active DFGin BLAminus in-in in-in DBQ Type1 117 - 389 None None 7
Homo sapiens ACK1_HUMAN 1U4DB 2.1 Active DFGin BLAminus in-in in-in DBQ Type1 117 - 390 None None 0
Homo sapiens ACK1_HUMAN 1U54B 2.8 Active DFGin BLAminus in-in in-in ACP Type1 117 - 388 None None 0
Homo sapiens ACK1_HUMAN 4HZSA 3.23 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 115 - 446 None None 13
Homo sapiens ACK1_HUMAN 4HZSB 3.23 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 115 - 446 None None 13
Homo sapiens ACK1_HUMAN 4HZSC 3.23 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 115 - 446 None None 13
Homo sapiens ACK1_HUMAN 4HZSD 3.23 Inactive DFGin BLBplus out-out out-out No_ligand No_ligand 115 - 446 None None 13
Homo sapiens ACK1_HUMAN 8HMTD 3.17 Inactive DFGin None in-out in-in LWX Type1.5_Back 117 - 389 None None 0
Homo sapiens ACK1_HUMAN 5ZXBA 2.198 Inactive DFGout None in-in none-none 9KO Type2 117 - 389 None None 21
Homo sapiens ACK1_HUMAN 5ZXBB 2.198 Inactive DFGout None in-in none-none 9KO Type2 117 - 389 None None 21

TNK2 (Activated CDC42 kinase 1)

No non-human structures known.