RIPK2 (Receptor-interacting serine/threonine-protein kinase 2)

Group: TKL
Uniprot: RIPK2_HUMAN
Domain boundary: 18 - 292


Total number of chains: 67
Spatial Dihedral Chains Representative
DFGin BLAminus 44 AF-O43353-K1A
DFGin BLBminus 3 6S1FA
DFGin BLBplus 10 5NG3A
DFGin None 4 6FU5B
DFGout BBAminus 3 6ES0A
DFGout None 3 5AR7A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-O43353-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 10 - 300 None None 0
8AZAA 3.15 None DFGin BLAminus in-out in-none No_ligand No_ligand 8 - 314 None None 13
8AZAB 3.15 None DFGin BLAminus in-out in-none No_ligand No_ligand 8 - 314 None None 25
5AR2A 2.44 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 4 - 310 None None 14
5AR2B 2.44 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 4 - 310 None None 11
5NG0A 2.0 Inactive DFGin BLAminus in-in in-out ACP Type1 6 - 300 L294F None 15
5NG0B 2.0 Active DFGin BLAminus in-in in-in ACP Type1 5 - 299 L294F None 10
5W5OA 2.89 None DFGin BLAminus in-none in-out 9XA Type1 5 - 310 None None 15
5W5OB 2.89 None DFGin BLAminus in-none in-out 9XA Type1 5 - 310 None None 15
5W5OC 2.89 None DFGin BLAminus in-none in-out 9XA Type1 5 - 310 None None 15
5W5OD 2.89 None DFGin BLAminus in-none in-out 9XA Type1 5 - 310 None None 15
5W5OE 2.89 Inactive DFGin BLAminus in-in in-out 9XA Type1 5 - 310 None None 15
5W5OF 2.89 None DFGin BLAminus in-none in-out 9XA Type1 5 - 310 None None 15
5W5OG 2.89 None DFGin BLAminus in-none in-out 9XA Type1 5 - 310 None None 15
5W5OH 2.89 Inactive DFGin BLAminus in-in in-out 9XA Type1 5 - 310 None None 15
5W5OI 2.89 None DFGin BLAminus in-none in-out 9XA Type1 5 - 310 None None 15
5W5OJ 2.89 Inactive DFGin BLAminus in-in in-out 9XA Type1 5 - 310 None None 15
5W5OK 2.89 Inactive DFGin BLAminus in-in in-out 9XA Type1 5 - 310 None None 15
5W5OL 2.89 Inactive DFGin BLAminus in-in in-out 9XA Type1 5 - 310 None None 15
5W5OM 2.89 None DFGin BLAminus in-none in-out 9XA Type1 5 - 310 None None 15
5W5ON 2.89 None DFGin BLAminus in-none in-out 9XA Type1 5 - 310 None None 15
5W5OO 2.89 Inactive DFGin BLAminus in-in in-out 9XA Type1 5 - 310 None None 15
5W5OP 2.89 None DFGin BLAminus in-none in-out 9XA Type1 5 - 310 None None 15
6HMXA 2.53 Inactive DFGin BLAminus in-in in-out GEZ Type1 5 - 310 None None 15
6HMXB 2.53 Inactive DFGin BLAminus in-in in-out GEZ Type1 5 - 310 None None 14
6SZEB 2.94 Inactive DFGin BLAminus in-in in-out M2B Type1 5 - 310 None None 15
6SZJB 2.53 None DFGin BLAminus in-in none-out M5W Type1 5 - 310 None None 17
6FU5A 3.26 None DFGin BLAminus in-in none-out E7N Type1 5 - 315 None None 20
6S1FB 3.11 None DFGin BLAminus in-out in-none KRE Type1 5 - 315 None None 14
6S1FD 3.11 Inactive DFGin BLAminus in-in in-out KRE Type1 5 - 316 None None 17
5AR3A 3.23 Inactive DFGin BLAminus in-in in-out ACP Type1 6 - 310 None None 14
5AR3B 3.23 None DFGin BLAminus in-in in-none ACP Type1 6 - 310 None None 16
5AR5A 2.66 Inactive DFGin BLAminus in-in in-out IQ7 Type1 4 - 310 None None 13
5AR5B 2.66 None DFGin BLAminus in-in in-none IQ7 Type1 4 - 310 None None 17
5J79A 2.69 Active DFGin BLAminus in-in in-in 6GE Type1 2 - 310 None None 10
5J79B 2.69 Inactive DFGin BLAminus in-in in-out 6GE Type1 5 - 310 None None 15
5NG2A 2.8 Inactive DFGin BLAminus in-in in-out STU Type1 5 - 298 D146N None 14
5NG2B 2.8 Inactive DFGin BLAminus in-in in-out STU Type1 5 - 298 D146N None 15
6UL8A 2.68 Inactive DFGin BLAminus in-in in-out Q9J Type1.5_Back 5 - 310 C7S,S168C None 17
6UL8B 2.68 Inactive DFGin BLAminus in-in in-out Q9J Type1.5_Back 5 - 310 C7S,S168C None 17
6RN8A 2.69 Inactive DFGin BLAminus in-in in-out K9T Type1.5_Back 5 - 310 None None 15
6RN8B 2.69 Inactive DFGin BLAminus in-in in-out K9T Type1.5_Back 5 - 310 None None 13
6RNAA 2.62 Inactive DFGin BLAminus in-in in-out KA2 Type1.5_Back 5 - 310 None None 14
6RNAB 2.62 Inactive DFGin BLAminus in-in in-out KA2 Type1.5_Back 4 - 310 None None 13
6S1FA 3.11 Inactive DFGin BLBminus in-in out-out KRE Type1 5 - 316 None None 16
6S1FC 3.11 Inactive DFGin BLBminus in-in out-out KRE Type1 5 - 315 None None 16
5AR8B 2.79 Inactive DFGin BLBminus out-out none-out XYW Type1.5_Back 8 - 310 None None 19
5NG3A 2.6 Inactive DFGin BLBplus out-none out-out No_ligand No_ligand 8 - 297 K47R X111 6
5NG3B 2.6 Inactive DFGin BLBplus out-none out-out No_ligand No_ligand 9 - 297 K47R None 8
5NG3C 2.6 Inactive DFGin BLBplus out-none out-out No_ligand No_ligand 9 - 297 K47R None 9
5NG3D 2.6 Inactive DFGin BLBplus out-none out-out No_ligand No_ligand 9 - 297 K47R X111 6
6SZEA 2.94 Inactive DFGin BLBplus in-in none-none M2B Type1 5 - 310 None None 20
6SZJA 2.53 Inactive DFGin BLBplus in-in none-out M5W Type1 5 - 310 None None 20
5AR4A 2.7 Inactive DFGin BLBplus in-in none-none SB2 Type1 5 - 310 None None 21
5AR4B 2.7 Inactive DFGin BLBplus in-in none-out SB2 Type1 6 - 310 None None 20
5J7BA 2.53 Inactive DFGin BLBplus in-in none-out 6GD Type1 5 - 310 None None 20
5J7BB 2.53 Inactive DFGin BLBplus in-in none-out 6GD Type1 4 - 310 None None 18
5W5JA 2.85 Inactive DFGin None none-none none-none 9WS Type1 9 - 310 None None 23
5W5JB 2.85 Inactive DFGin None out-none none-none 9WS Type1 10 - 311 None None 23
6FU5B 3.26 Inactive DFGin None in-in none-out E7N Type1 5 - 316 None None 22
5AR8A 2.79 Inactive DFGin None out-out none-out XYW Type1.5_Back 9 - 310 None None 22
6ES0A 2.38 Inactive DFGout BBAminus in-in out-out BW8 Type2 5 - 316 None None 17
6ES0B 2.38 Inactive DFGout BBAminus in-in out-out BW8 Type2 5 - 315 None None 16
5AR7B 2.71 Inactive DFGout BBAminus in-in none-out SR8 Type2 6 - 310 None None 21
4C8BA 2.75 Inactive DFGout None in-in none-out 0LI Type2 8 - 316 None None 22
4C8BB 2.75 Inactive DFGout None in-in none-out 0LI Type2 9 - 316 None None 22
5AR7A 2.71 Inactive DFGout None in-in out-none SR8 Type2 6 - 310 None None 16

RIPK2 (Receptor-interacting serine/threonine-protein kinase 2)

Group: TKL
Total number of chains: 67
Spatial Dihedral Chains Representative
DFGin BLAminus 44 AF-O43353-K1A
DFGin BLBminus 3 6S1FA
DFGin BLBplus 10 5NG3A
DFGin None 4 6FU5B
DFGout BBAminus 3 6ES0A
DFGout None 3 5AR7A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens RIPK2_HUMAN AF-O43353-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 10 - 300 None None 0
Homo sapiens RIPK2_HUMAN 8AZAA 3.15 None DFGin BLAminus in-out in-none No_ligand No_ligand 8 - 314 None None 13
Homo sapiens RIPK2_HUMAN 8AZAB 3.15 None DFGin BLAminus in-out in-none No_ligand No_ligand 8 - 314 None None 25
Homo sapiens RIPK2_HUMAN 5AR2A 2.44 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 4 - 310 None None 14
Homo sapiens RIPK2_HUMAN 5AR2B 2.44 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 4 - 310 None None 11
Homo sapiens RIPK2_HUMAN 5NG0A 2.0 Inactive DFGin BLAminus in-in in-out ACP Type1 6 - 300 L294F None 15
Homo sapiens RIPK2_HUMAN 5NG0B 2.0 Active DFGin BLAminus in-in in-in ACP Type1 5 - 299 L294F None 10
Homo sapiens RIPK2_HUMAN 5W5OA 2.89 None DFGin BLAminus in-none in-out 9XA Type1 5 - 310 None None 15
Homo sapiens RIPK2_HUMAN 5W5OB 2.89 None DFGin BLAminus in-none in-out 9XA Type1 5 - 310 None None 15
Homo sapiens RIPK2_HUMAN 5W5OC 2.89 None DFGin BLAminus in-none in-out 9XA Type1 5 - 310 None None 15
Homo sapiens RIPK2_HUMAN 5W5OD 2.89 None DFGin BLAminus in-none in-out 9XA Type1 5 - 310 None None 15
Homo sapiens RIPK2_HUMAN 5W5OE 2.89 Inactive DFGin BLAminus in-in in-out 9XA Type1 5 - 310 None None 15
Homo sapiens RIPK2_HUMAN 5W5OF 2.89 None DFGin BLAminus in-none in-out 9XA Type1 5 - 310 None None 15
Homo sapiens RIPK2_HUMAN 5W5OG 2.89 None DFGin BLAminus in-none in-out 9XA Type1 5 - 310 None None 15
Homo sapiens RIPK2_HUMAN 5W5OH 2.89 Inactive DFGin BLAminus in-in in-out 9XA Type1 5 - 310 None None 15
Homo sapiens RIPK2_HUMAN 5W5OI 2.89 None DFGin BLAminus in-none in-out 9XA Type1 5 - 310 None None 15
Homo sapiens RIPK2_HUMAN 5W5OJ 2.89 Inactive DFGin BLAminus in-in in-out 9XA Type1 5 - 310 None None 15
Homo sapiens RIPK2_HUMAN 5W5OK 2.89 Inactive DFGin BLAminus in-in in-out 9XA Type1 5 - 310 None None 15
Homo sapiens RIPK2_HUMAN 5W5OL 2.89 Inactive DFGin BLAminus in-in in-out 9XA Type1 5 - 310 None None 15
Homo sapiens RIPK2_HUMAN 5W5OM 2.89 None DFGin BLAminus in-none in-out 9XA Type1 5 - 310 None None 15
Homo sapiens RIPK2_HUMAN 5W5ON 2.89 None DFGin BLAminus in-none in-out 9XA Type1 5 - 310 None None 15
Homo sapiens RIPK2_HUMAN 5W5OO 2.89 Inactive DFGin BLAminus in-in in-out 9XA Type1 5 - 310 None None 15
Homo sapiens RIPK2_HUMAN 5W5OP 2.89 None DFGin BLAminus in-none in-out 9XA Type1 5 - 310 None None 15
Homo sapiens RIPK2_HUMAN 6HMXA 2.53 Inactive DFGin BLAminus in-in in-out GEZ Type1 5 - 310 None None 15
Homo sapiens RIPK2_HUMAN 6HMXB 2.53 Inactive DFGin BLAminus in-in in-out GEZ Type1 5 - 310 None None 14
Homo sapiens RIPK2_HUMAN 6SZEB 2.94 Inactive DFGin BLAminus in-in in-out M2B Type1 5 - 310 None None 15
Homo sapiens RIPK2_HUMAN 6SZJB 2.53 None DFGin BLAminus in-in none-out M5W Type1 5 - 310 None None 17
Homo sapiens RIPK2_HUMAN 6FU5A 3.26 None DFGin BLAminus in-in none-out E7N Type1 5 - 315 None None 20
Homo sapiens RIPK2_HUMAN 6S1FB 3.11 None DFGin BLAminus in-out in-none KRE Type1 5 - 315 None None 14
Homo sapiens RIPK2_HUMAN 6S1FD 3.11 Inactive DFGin BLAminus in-in in-out KRE Type1 5 - 316 None None 17
Homo sapiens RIPK2_HUMAN 5AR3A 3.23 Inactive DFGin BLAminus in-in in-out ACP Type1 6 - 310 None None 14
Homo sapiens RIPK2_HUMAN 5AR3B 3.23 None DFGin BLAminus in-in in-none ACP Type1 6 - 310 None None 16
Homo sapiens RIPK2_HUMAN 5AR5A 2.66 Inactive DFGin BLAminus in-in in-out IQ7 Type1 4 - 310 None None 13
Homo sapiens RIPK2_HUMAN 5AR5B 2.66 None DFGin BLAminus in-in in-none IQ7 Type1 4 - 310 None None 17
Homo sapiens RIPK2_HUMAN 5J79A 2.69 Active DFGin BLAminus in-in in-in 6GE Type1 2 - 310 None None 10
Homo sapiens RIPK2_HUMAN 5J79B 2.69 Inactive DFGin BLAminus in-in in-out 6GE Type1 5 - 310 None None 15
Homo sapiens RIPK2_HUMAN 5NG2A 2.8 Inactive DFGin BLAminus in-in in-out STU Type1 5 - 298 D146N None 14
Homo sapiens RIPK2_HUMAN 5NG2B 2.8 Inactive DFGin BLAminus in-in in-out STU Type1 5 - 298 D146N None 15
Homo sapiens RIPK2_HUMAN 6UL8A 2.68 Inactive DFGin BLAminus in-in in-out Q9J Type1.5_Back 5 - 310 C7S,S168C None 17
Homo sapiens RIPK2_HUMAN 6UL8B 2.68 Inactive DFGin BLAminus in-in in-out Q9J Type1.5_Back 5 - 310 C7S,S168C None 17
Homo sapiens RIPK2_HUMAN 6RN8A 2.69 Inactive DFGin BLAminus in-in in-out K9T Type1.5_Back 5 - 310 None None 15
Homo sapiens RIPK2_HUMAN 6RN8B 2.69 Inactive DFGin BLAminus in-in in-out K9T Type1.5_Back 5 - 310 None None 13
Homo sapiens RIPK2_HUMAN 6RNAA 2.62 Inactive DFGin BLAminus in-in in-out KA2 Type1.5_Back 5 - 310 None None 14
Homo sapiens RIPK2_HUMAN 6RNAB 2.62 Inactive DFGin BLAminus in-in in-out KA2 Type1.5_Back 4 - 310 None None 13
Homo sapiens RIPK2_HUMAN 6S1FA 3.11 Inactive DFGin BLBminus in-in out-out KRE Type1 5 - 316 None None 16
Homo sapiens RIPK2_HUMAN 6S1FC 3.11 Inactive DFGin BLBminus in-in out-out KRE Type1 5 - 315 None None 16
Homo sapiens RIPK2_HUMAN 5AR8B 2.79 Inactive DFGin BLBminus out-out none-out XYW Type1.5_Back 8 - 310 None None 19
Homo sapiens RIPK2_HUMAN 5NG3A 2.6 Inactive DFGin BLBplus out-none out-out No_ligand No_ligand 8 - 297 K47R X111 6
Homo sapiens RIPK2_HUMAN 5NG3B 2.6 Inactive DFGin BLBplus out-none out-out No_ligand No_ligand 9 - 297 K47R None 8
Homo sapiens RIPK2_HUMAN 5NG3C 2.6 Inactive DFGin BLBplus out-none out-out No_ligand No_ligand 9 - 297 K47R None 9
Homo sapiens RIPK2_HUMAN 5NG3D 2.6 Inactive DFGin BLBplus out-none out-out No_ligand No_ligand 9 - 297 K47R X111 6
Homo sapiens RIPK2_HUMAN 6SZEA 2.94 Inactive DFGin BLBplus in-in none-none M2B Type1 5 - 310 None None 20
Homo sapiens RIPK2_HUMAN 6SZJA 2.53 Inactive DFGin BLBplus in-in none-out M5W Type1 5 - 310 None None 20
Homo sapiens RIPK2_HUMAN 5AR4A 2.7 Inactive DFGin BLBplus in-in none-none SB2 Type1 5 - 310 None None 21
Homo sapiens RIPK2_HUMAN 5AR4B 2.7 Inactive DFGin BLBplus in-in none-out SB2 Type1 6 - 310 None None 20
Homo sapiens RIPK2_HUMAN 5J7BA 2.53 Inactive DFGin BLBplus in-in none-out 6GD Type1 5 - 310 None None 20
Homo sapiens RIPK2_HUMAN 5J7BB 2.53 Inactive DFGin BLBplus in-in none-out 6GD Type1 4 - 310 None None 18
Homo sapiens RIPK2_HUMAN 5W5JA 2.85 Inactive DFGin None none-none none-none 9WS Type1 9 - 310 None None 23
Homo sapiens RIPK2_HUMAN 5W5JB 2.85 Inactive DFGin None out-none none-none 9WS Type1 10 - 311 None None 23
Homo sapiens RIPK2_HUMAN 6FU5B 3.26 Inactive DFGin None in-in none-out E7N Type1 5 - 316 None None 22
Homo sapiens RIPK2_HUMAN 5AR8A 2.79 Inactive DFGin None out-out none-out XYW Type1.5_Back 9 - 310 None None 22
Homo sapiens RIPK2_HUMAN 6ES0A 2.38 Inactive DFGout BBAminus in-in out-out BW8 Type2 5 - 316 None None 17
Homo sapiens RIPK2_HUMAN 6ES0B 2.38 Inactive DFGout BBAminus in-in out-out BW8 Type2 5 - 315 None None 16
Homo sapiens RIPK2_HUMAN 5AR7B 2.71 Inactive DFGout BBAminus in-in none-out SR8 Type2 6 - 310 None None 21
Homo sapiens RIPK2_HUMAN 4C8BA 2.75 Inactive DFGout None in-in none-out 0LI Type2 8 - 316 None None 22
Homo sapiens RIPK2_HUMAN 4C8BB 2.75 Inactive DFGout None in-in none-out 0LI Type2 9 - 316 None None 22
Homo sapiens RIPK2_HUMAN 5AR7A 2.71 Inactive DFGout None in-in out-none SR8 Type2 6 - 310 None None 16

RIPK2 (Receptor-interacting serine/threonine-protein kinase 2)

No non-human structures known.