Protein kinases in complex with EUI (Cobimetinib)

Total number of genes: 1
Total number of chains: 3
Spatial Dihedral Chains Representative
DFGin BLBplus 3 4AN2A
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 4LMNA 2.8 Inactive DFGin BLBplus out-out out-out ANP EUI Type1 Type3
STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 7M0VB 3.16 Inactive DFGin BLBplus out-out out-out ANP EUI Type1 Type3
STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 4AN2A 2.5 Inactive DFGin BLBplus out-out out-out EUI ACP Type3 Type1

Protein kinases in complex with EUI

Total number of genes: 1
Total number of chains: 4
Spatial Dihedral Chains Representative
DFGin BLBplus 4 4AN2A
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 4LMNA 2.8 Inactive DFGin BLBplus out-out out-out ANP EUI Type1 Type3
Homo sapiens STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 7M0VB 3.16 Inactive DFGin BLBplus out-out out-out ANP EUI Type1 Type3
Homo sapiens STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 4AN2A 2.5 Inactive DFGin BLBplus out-out out-out EUI ACP Type3 Type1
Oryctolagus cuniculus STE MAP2K1 MP2K1_RABIT Dual specificity mitogen-activated protein kinase kinase 1 7JUYC 3.096 Inactive DFGin BLBplus out-out out-out ANP EUI Type1 Type3

Protein kinases in complex with EUI

Total number of genes: 1
Total number of chains: 1
Spatial Dihedral Chains Representative
DFGin BLBplus 1 7JUYC
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Oryctolagus cuniculus STE MAP2K1 MP2K1_RABIT Dual specificity mitogen-activated protein kinase kinase 1 7JUYC 3.096 Inactive DFGin BLBplus out-out out-out ANP EUI Type1 Type3