RNASEL (2-5A-dependent ribonuclease)

Pseudokinase
Group: OTHER
Uniprot: RN5A_HUMAN
Domain boundary: 361 - 586


Total number of chains: 3
Spatial Dihedral Chains Representative
DFGin BLAminus 3 4OAUC
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
4OAUC 2.6 Active DFGin BLAminus in-in in-none ADP Type1 25 - 719 H672N None 0
4OAVB 2.1 Active DFGin BLAminus in-in in-none ACP Type1 24 - 717 H672N None 0
4OAVD 2.1 Active DFGin BLAminus in-in in-none ACP Type1 26 - 719 H672N None 0

RNASEL (2-5A-dependent ribonuclease)

Pseudokinase
Group: OTHER
Total number of chains: 23
Spatial Dihedral Chains Representative
DFGin BLAminus 15 6M12a
DFGin ABAminus 8 4O1PB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens RN5A_HUMAN 4OAUC 2.6 Active DFGin BLAminus in-in in-none ADP Type1 25 - 719 H672N None 0
Homo sapiens RN5A_HUMAN 4OAVB 2.1 Active DFGin BLAminus in-in in-none ACP Type1 24 - 717 H672N None 0
Homo sapiens RN5A_HUMAN 4OAVD 2.1 Active DFGin BLAminus in-in in-none ACP Type1 26 - 719 H672N None 0
Sus scrofa A5H025_PIG 4O1OA 3.27 Inactive DFGin ABAminus in-in in-none 25L Allosteric 22 - 729 None None 0
Sus scrofa A5H025_PIG 4O1OB 3.27 Inactive DFGin ABAminus in-in in-none 25L Allosteric 22 - 729 None None 0
Sus scrofa A5H025_PIG 4O1OC 3.27 Inactive DFGin ABAminus in-in in-none 25L Allosteric 22 - 729 None None 0
Sus scrofa A5H025_PIG 4O1OD 3.27 Inactive DFGin ABAminus in-in in-none 25L Allosteric 22 - 729 None None 0
Sus scrofa A5H025_PIG 4O1PA 2.5 Inactive DFGin ABAminus in-in in-none ANP 25L Type1 Allosteric 22 - 729 None None 0
Sus scrofa A5H025_PIG 4O1PB 2.5 Inactive DFGin ABAminus in-in in-none ANP 25L Type1 Allosteric 22 - 729 None None 0
Sus scrofa A5H025_PIG 4O1PC 2.5 Inactive DFGin ABAminus in-in in-none ANP 25L Type1 Allosteric 22 - 729 None None 0
Sus scrofa A5H025_PIG 4O1PD 2.5 Inactive DFGin ABAminus in-in in-none ANP 25L Type1 Allosteric 22 - 729 None None 0
Sus scrofa A5H025_PIG 6M11a 2.46 Active DFGin BLAminus in-in in-none 25A B49 Allosteric Type1 22 - 727 None None 0
Sus scrofa A5H025_PIG 6M11b 2.46 Active DFGin BLAminus in-in in-none 25A B49 Allosteric Type1 23 - 727 None None 0
Sus scrofa A5H025_PIG 6M12b 2.4 Active DFGin BLAminus in-in in-none 25L J60 Allosteric Type1 24 - 726 None None 0
Sus scrofa A5H025_PIG 7DSYa 2.651 Active DFGin BLAminus in-in in-none 25A HFX Allosteric Type1 22 - 727 None None 0
Sus scrofa A5H025_PIG 7DSYb 2.651 Active DFGin BLAminus in-in in-none 25A HFX Allosteric Type1 23 - 727 None None 0
Sus scrofa A5H025_PIG 7DTSa 2.63 Active DFGin BLAminus in-in in-none 25A 27K Allosteric Type1 22 - 727 None None 0
Sus scrofa A5H025_PIG 7DTSb 2.63 Active DFGin BLAminus in-in in-none 25A 27K Allosteric Type1 23 - 727 None None 0
Sus scrofa A5H025_PIG 7ELWa 3.55 Active DFGin BLAminus in-in in-none 25L MYC Allosteric Type1 22 - 727 None None 0
Sus scrofa A5H025_PIG 7ELWb 3.55 Active DFGin BLAminus in-in in-none 25L MYC Allosteric Type1 23 - 727 None None 0
Sus scrofa A5H025_PIG 6M12a 2.4 Active DFGin BLAminus in-in in-none J60 25L Type1 Allosteric 22 - 727 None None 0
Sus scrofa A5H025_PIG 6M13a 2.56 Active DFGin BLAminus in-in in-none BWC 25L Type1 Allosteric 22 - 727 None None 0
Sus scrofa A5H025_PIG 6M13b 2.56 Active DFGin BLAminus in-in in-none BWC 25L Type1 Allosteric 23 - 729 None None 0

RNASEL (2-5A-dependent ribonuclease)

Group: OTHER
Total number of chains: 20
Spatial Dihedral Chains Representative
DFGin BLAminus 12 6M12a
DFGin ABAminus 8 4O1PB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Sus scrofa A5H025_PIG 4O1OA 3.27 Inactive DFGin ABAminus in-in in-none 25L Allosteric 22 - 729 None None 0
Sus scrofa A5H025_PIG 4O1OB 3.27 Inactive DFGin ABAminus in-in in-none 25L Allosteric 22 - 729 None None 0
Sus scrofa A5H025_PIG 4O1OC 3.27 Inactive DFGin ABAminus in-in in-none 25L Allosteric 22 - 729 None None 0
Sus scrofa A5H025_PIG 4O1OD 3.27 Inactive DFGin ABAminus in-in in-none 25L Allosteric 22 - 729 None None 0
Sus scrofa A5H025_PIG 4O1PA 2.5 Inactive DFGin ABAminus in-in in-none ANP 25L Type1 Allosteric 22 - 729 None None 0
Sus scrofa A5H025_PIG 4O1PB 2.5 Inactive DFGin ABAminus in-in in-none ANP 25L Type1 Allosteric 22 - 729 None None 0
Sus scrofa A5H025_PIG 4O1PC 2.5 Inactive DFGin ABAminus in-in in-none ANP 25L Type1 Allosteric 22 - 729 None None 0
Sus scrofa A5H025_PIG 4O1PD 2.5 Inactive DFGin ABAminus in-in in-none ANP 25L Type1 Allosteric 22 - 729 None None 0
Sus scrofa A5H025_PIG 6M11a 2.46 Active DFGin BLAminus in-in in-none 25A B49 Allosteric Type1 22 - 727 None None 0
Sus scrofa A5H025_PIG 6M11b 2.46 Active DFGin BLAminus in-in in-none 25A B49 Allosteric Type1 23 - 727 None None 0
Sus scrofa A5H025_PIG 6M12b 2.4 Active DFGin BLAminus in-in in-none 25L J60 Allosteric Type1 24 - 726 None None 0
Sus scrofa A5H025_PIG 7DSYa 2.651 Active DFGin BLAminus in-in in-none 25A HFX Allosteric Type1 22 - 727 None None 0
Sus scrofa A5H025_PIG 7DSYb 2.651 Active DFGin BLAminus in-in in-none 25A HFX Allosteric Type1 23 - 727 None None 0
Sus scrofa A5H025_PIG 7DTSa 2.63 Active DFGin BLAminus in-in in-none 25A 27K Allosteric Type1 22 - 727 None None 0
Sus scrofa A5H025_PIG 7DTSb 2.63 Active DFGin BLAminus in-in in-none 25A 27K Allosteric Type1 23 - 727 None None 0
Sus scrofa A5H025_PIG 7ELWa 3.55 Active DFGin BLAminus in-in in-none 25L MYC Allosteric Type1 22 - 727 None None 0
Sus scrofa A5H025_PIG 7ELWb 3.55 Active DFGin BLAminus in-in in-none 25L MYC Allosteric Type1 23 - 727 None None 0
Sus scrofa A5H025_PIG 6M12a 2.4 Active DFGin BLAminus in-in in-none J60 25L Type1 Allosteric 22 - 727 None None 0
Sus scrofa A5H025_PIG 6M13a 2.56 Active DFGin BLAminus in-in in-none BWC 25L Type1 Allosteric 22 - 727 None None 0
Sus scrofa A5H025_PIG 6M13b 2.56 Active DFGin BLAminus in-in in-none BWC 25L Type1 Allosteric 23 - 729 None None 0