EPHA2 (Ephrin type-A receptor 2)

Group: TYR
Uniprot: EPHA2_HUMAN
Domain boundary: 613 - 873


Total number of chains: 79
Spatial Dihedral Chains Representative
DFGin BLAminus 14 AF-P29317-K1A
DFGin ABAminus 8 7KJBA
DFGin BLBminus 28 5NKGA
DFGin None 3 5IA1A
DFGout BBAminus 22 8BOKA
DFGout None 4 5IA5A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
4TRLA 2.452 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 599 - 875 None X772 1
7KJBA 2.8 Inactive DFGin ABAminus in-in out-in No_ligand No_ligand 591 - 965 S897E,S901E None 0
5NK0A 1.597 Inactive DFGin ABAminus in-in none-none 91E Type1 602 - 894 None None 19
5NK8A 1.761 Inactive DFGin ABAminus in-in none-none 90Z Type1 605 - 894 None None 20
6FNHA 1.379 Inactive DFGin ABAminus in-in out-in DXK Type1 602 - 889 None None 10
6FNHB 1.379 Inactive DFGin ABAminus in-in out-out DXK Type1 602 - 882 None None 7
5NK3A 1.586 Inactive DFGin ABAminus in-in out-in 92Q Type1.5_Back 601 - 888 None None 3
8QQYA 1.8 Inactive DFGin ABAminus in-in out-in WT3 Type1.5_Back 605 - 896 None None 10
AF-P29317-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 605 - 881 None None 0
4P2KA 1.499 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 600 - 876 None None 12
5I9UA 1.889 Active DFGin BLAminus in-in in-in No_ligand No_ligand 601 - 894 None None 13
5EK7A 1.901 Inactive DFGin BLAminus in-in out-in No_ligand No_ligand 586 - 875 None None 0
5EK7B 1.901 Inactive DFGin BLAminus in-in out-in No_ligand No_ligand 586 - 875 None None 0
5I9VA 1.458 Active DFGin BLAminus in-in in-in AGS Type1 605 - 896 None None 13
5IA0A 1.948 None DFGin BLAminus in-in none-in A5B Type1 604 - 889 None None 19
5NKAA 1.377 None DFGin BLAminus in-in none-in 91H Type1 605 - 895 None None 18
6FNHC 1.379 None DFGin BLAminus in-in none-none DXK Type1 600 - 890 None None 19
8BINA 1.5 Inactive DFGin BLAminus in-in out-in QRR Type1 605 - 887 None None 9
1MQBA 2.3 None DFGin BLAminus in-out none-in ANP Type1 605 - 887 None None 17
1MQBB 2.3 Active DFGin BLAminus in-in in-in ANP Type1 602 - 883 None None 13
7KJAB 1.75 None DFGin BLAminus in-in none-none ACP Type1 590 - 965 None None 20
8BIOA 1.6 Inactive DFGin BLAminus in-in out-in QRD Type1.5_Back 605 - 894 None None 7
5I9WA 1.359 Inactive DFGin BLBminus in-in none-in ANP Type1 605 - 895 None None 18
5I9XA 1.427 Inactive DFGin BLBminus in-in out-in DB8 Type1 604 - 896 None None 4
5I9YA 1.228 Inactive DFGin BLBminus in-in out-none 1N1 Type1 600 - 896 None None 7
5I9ZA 1.698 Inactive DFGin BLBminus in-in out-in 627 Type1 604 - 896 None None 14
5IA0B 1.948 Inactive DFGin BLBminus in-in out-in A5B Type1 600 - 882 None None 14
5IA0C 1.948 Inactive DFGin BLBminus in-in none-none A5B Type1 600 - 890 None None 18
5IA3A 1.788 Inactive DFGin BLBminus in-in out-in P17 Type1 602 - 896 None None 16
5NJZA 1.768 Inactive DFGin BLBminus in-in none-in 8ZH Type1 604 - 896 None None 17
5NK1A 1.548 Inactive DFGin BLBminus in-in out-in 90N Type1 604 - 896 None None 4
5NK2A 1.649 Inactive DFGin BLBminus in-in out-in 8ZZ Type1 598 - 896 None None 4
5NK4A 1.45 Inactive DFGin BLBminus in-in out-in 90E Type1 601 - 896 None None 0
5NK5A 1.329 Inactive DFGin BLBminus in-in out-in 90K Type1 605 - 896 None None 1
5NK6A 1.267 Inactive DFGin BLBminus in-out out-in 90W Type1 605 - 896 None None 3
5NK7A 1.889 Inactive DFGin BLBminus in-in out-in 8ZZ Type1 604 - 896 None None 4
5NK9A 1.588 Inactive DFGin BLBminus in-out out-in 912 Type1 605 - 896 None None 2
5NKBA 1.5 Inactive DFGin BLBminus in-in out-in 8ZT Type1 605 - 896 None None 2
5NKCA 1.448 Inactive DFGin BLBminus in-in out-in 90T Type1 601 - 896 None None 5
5NKDA 1.408 Inactive DFGin BLBminus in-in out-in 91K Type1 600 - 896 None None 4
5NKEA 1.39 Inactive DFGin BLBminus in-in out-in 90B Type1 605 - 896 None None 0
5NKFA 1.099 Inactive DFGin BLBminus in-out out-in 8ZN Type1 605 - 896 None None 0
5NKGA 1.1 Inactive DFGin BLBminus in-out out-in 8ZK Type1 605 - 896 None None 0
5NKHA 1.29 Inactive DFGin BLBminus in-in out-in 8ZQ Type1 601 - 895 None None 0
5NKIA 1.675 Inactive DFGin BLBminus in-in none-none 8ZW Type1 604 - 896 None None 20
8BK0A 1.7 Inactive DFGin BLBminus in-in out-in QJI Type1 605 - 887 None None 11
7KJCA 2.3 Inactive DFGin BLBminus in-in out-in ACP Type1 590 - 976 S901E None 5
7KJCB 2.3 Inactive DFGin BLBminus in-in none-none ACP Type1 590 - 965 S901E None 20
7KJAA 1.75 Inactive DFGin BLBminus in-in none-none ACP Type1 590 - 976 None None 20
5IA2A 1.619 Inactive DFGin BLBminus in-out out-in L66 Type1.5_Back 598 - 888 None None 0
4PDOA 2.104 Inactive DFGin None in-out none-in No_ligand No_ligand 590 - 875 None None 18
4PDOB 2.104 Inactive DFGin None in-out none-in No_ligand No_ligand 590 - 875 None None 18
5IA1A 2.036 Inactive DFGin None in-in none-in ZZL Type1 605 - 888 None None 17
8XPVA 1.55 Inactive DFGout BBAminus in-in none-in 4Z5 Type2 604 - 895 None None 19
6FNFA 1.556 Inactive DFGout BBAminus in-in none-none DXH Type2 606 - 894 None None 18
6FNGA 1.038 Inactive DFGout BBAminus in-in none-in DWT Type2 599 - 897 None None 17
6HESA 1.128 Inactive DFGout BBAminus in-in none-none G0H Type2 599 - 896 None None 18
6HETA 1.208 Inactive DFGout BBAminus in-in none-none G0Q Type2 605 - 896 None None 19
6HEUA 1.719 Inactive DFGout BBAminus in-in none-none G0N Type2 600 - 896 None None 18
6HEVA 1.28 Inactive DFGout BBAminus in-in none-in G0K Type2 600 - 896 None None 17
6HEWA 1.268 Inactive DFGout BBAminus in-in none-out G0E Type2 605 - 896 None None 15
6HEXA 1.413 Inactive DFGout BBAminus in-in none-none G02 Type2 605 - 896 None None 19
6HEYA 1.367 Inactive DFGout BBAminus in-in none-out FZW Type2 600 - 896 None None 16
6Q7BA 1.009 Inactive DFGout BBAminus in-in none-out HO5 Type2 599 - 896 None None 15
6Q7CA 1.049 Inactive DFGout BBAminus in-in none-out HOK Type2 599 - 896 None None 15
6Q7DA 0.978 Inactive DFGout BBAminus in-in none-out HOT Type2 600 - 896 None None 18
6Q7EA 1.059 Inactive DFGout BBAminus in-in none-none HMW Type2 601 - 896 None None 19
6Q7GA 1.047 Inactive DFGout BBAminus in-in none-none HO8 Type2 601 - 896 None None 19
8BOCA 1.9 Inactive DFGout BBAminus in-in out-in QUF Type2 605 - 888 None None 0
8BODA 1.5 Inactive DFGout BBAminus in-in none-none QTX Type2 605 - 896 None None 19
8BOGA 1.47 Inactive DFGout BBAminus in-in none-none QUU Type2 600 - 895 None None 19
8BOHA 1.42 Inactive DFGout BBAminus in-in none-out R0T Type2 604 - 896 None None 18
8BOIA 1.63 Inactive DFGout BBAminus in-in none-out R0O Type2 604 - 896 None None 18
8BOKA 2.02 Inactive DFGout BBAminus in-in out-in R0X Type2 605 - 890 None None 0
8BOMA 1.12 Inactive DFGout BBAminus in-in none-none QU6 Type2 605 - 896 None None 19
5IA4A 1.797 Inactive DFGout None in-out out-in 88Z Type2 605 - 877 None None 0
5IA5A 1.776 Inactive DFGout None in-out out-in GV0 Type2 605 - 880 None None 0
6Q7FA 1.204 Inactive DFGout None in-in none-none HNZ Type2 605 - 896 None None 20
8BOFA 1.82 Inactive DFGout None in-in none-none R3L Type2 605 - 896 None None 21

EPHA2 (Ephrin type-A receptor 2)

Group: TYR
Total number of chains: 79
Spatial Dihedral Chains Representative
DFGin BLAminus 14 AF-P29317-K1A
DFGin ABAminus 8 7KJBA
DFGin BLBminus 28 5NKGA
DFGin None 3 5IA1A
DFGout BBAminus 22 8BOKA
DFGout None 4 5IA5A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens EPHA2_HUMAN 4TRLA 2.452 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 599 - 875 None X772 1
Homo sapiens EPHA2_HUMAN 7KJBA 2.8 Inactive DFGin ABAminus in-in out-in No_ligand No_ligand 591 - 965 S897E,S901E None 0
Homo sapiens EPHA2_HUMAN 5NK0A 1.597 Inactive DFGin ABAminus in-in none-none 91E Type1 602 - 894 None None 19
Homo sapiens EPHA2_HUMAN 5NK8A 1.761 Inactive DFGin ABAminus in-in none-none 90Z Type1 605 - 894 None None 20
Homo sapiens EPHA2_HUMAN 6FNHA 1.379 Inactive DFGin ABAminus in-in out-in DXK Type1 602 - 889 None None 10
Homo sapiens EPHA2_HUMAN 6FNHB 1.379 Inactive DFGin ABAminus in-in out-out DXK Type1 602 - 882 None None 7
Homo sapiens EPHA2_HUMAN 5NK3A 1.586 Inactive DFGin ABAminus in-in out-in 92Q Type1.5_Back 601 - 888 None None 3
Homo sapiens EPHA2_HUMAN 8QQYA 1.8 Inactive DFGin ABAminus in-in out-in WT3 Type1.5_Back 605 - 896 None None 10
Homo sapiens EPHA2_HUMAN AF-P29317-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 605 - 881 None None 0
Homo sapiens EPHA2_HUMAN 4P2KA 1.499 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 600 - 876 None None 12
Homo sapiens EPHA2_HUMAN 5I9UA 1.889 Active DFGin BLAminus in-in in-in No_ligand No_ligand 601 - 894 None None 13
Homo sapiens EPHA2_HUMAN 5EK7A 1.901 Inactive DFGin BLAminus in-in out-in No_ligand No_ligand 586 - 875 None None 0
Homo sapiens EPHA2_HUMAN 5EK7B 1.901 Inactive DFGin BLAminus in-in out-in No_ligand No_ligand 586 - 875 None None 0
Homo sapiens EPHA2_HUMAN 5I9VA 1.458 Active DFGin BLAminus in-in in-in AGS Type1 605 - 896 None None 13
Homo sapiens EPHA2_HUMAN 5IA0A 1.948 None DFGin BLAminus in-in none-in A5B Type1 604 - 889 None None 19
Homo sapiens EPHA2_HUMAN 5NKAA 1.377 None DFGin BLAminus in-in none-in 91H Type1 605 - 895 None None 18
Homo sapiens EPHA2_HUMAN 6FNHC 1.379 None DFGin BLAminus in-in none-none DXK Type1 600 - 890 None None 19
Homo sapiens EPHA2_HUMAN 8BINA 1.5 Inactive DFGin BLAminus in-in out-in QRR Type1 605 - 887 None None 9
Homo sapiens EPHA2_HUMAN 1MQBA 2.3 None DFGin BLAminus in-out none-in ANP Type1 605 - 887 None None 17
Homo sapiens EPHA2_HUMAN 1MQBB 2.3 Active DFGin BLAminus in-in in-in ANP Type1 602 - 883 None None 13
Homo sapiens EPHA2_HUMAN 7KJAB 1.75 None DFGin BLAminus in-in none-none ACP Type1 590 - 965 None None 20
Homo sapiens EPHA2_HUMAN 8BIOA 1.6 Inactive DFGin BLAminus in-in out-in QRD Type1.5_Back 605 - 894 None None 7
Homo sapiens EPHA2_HUMAN 5I9WA 1.359 Inactive DFGin BLBminus in-in none-in ANP Type1 605 - 895 None None 18
Homo sapiens EPHA2_HUMAN 5I9XA 1.427 Inactive DFGin BLBminus in-in out-in DB8 Type1 604 - 896 None None 4
Homo sapiens EPHA2_HUMAN 5I9YA 1.228 Inactive DFGin BLBminus in-in out-none 1N1 Type1 600 - 896 None None 7
Homo sapiens EPHA2_HUMAN 5I9ZA 1.698 Inactive DFGin BLBminus in-in out-in 627 Type1 604 - 896 None None 14
Homo sapiens EPHA2_HUMAN 5IA0B 1.948 Inactive DFGin BLBminus in-in out-in A5B Type1 600 - 882 None None 14
Homo sapiens EPHA2_HUMAN 5IA0C 1.948 Inactive DFGin BLBminus in-in none-none A5B Type1 600 - 890 None None 18
Homo sapiens EPHA2_HUMAN 5IA3A 1.788 Inactive DFGin BLBminus in-in out-in P17 Type1 602 - 896 None None 16
Homo sapiens EPHA2_HUMAN 5NJZA 1.768 Inactive DFGin BLBminus in-in none-in 8ZH Type1 604 - 896 None None 17
Homo sapiens EPHA2_HUMAN 5NK1A 1.548 Inactive DFGin BLBminus in-in out-in 90N Type1 604 - 896 None None 4
Homo sapiens EPHA2_HUMAN 5NK2A 1.649 Inactive DFGin BLBminus in-in out-in 8ZZ Type1 598 - 896 None None 4
Homo sapiens EPHA2_HUMAN 5NK4A 1.45 Inactive DFGin BLBminus in-in out-in 90E Type1 601 - 896 None None 0
Homo sapiens EPHA2_HUMAN 5NK5A 1.329 Inactive DFGin BLBminus in-in out-in 90K Type1 605 - 896 None None 1
Homo sapiens EPHA2_HUMAN 5NK6A 1.267 Inactive DFGin BLBminus in-out out-in 90W Type1 605 - 896 None None 3
Homo sapiens EPHA2_HUMAN 5NK7A 1.889 Inactive DFGin BLBminus in-in out-in 8ZZ Type1 604 - 896 None None 4
Homo sapiens EPHA2_HUMAN 5NK9A 1.588 Inactive DFGin BLBminus in-out out-in 912 Type1 605 - 896 None None 2
Homo sapiens EPHA2_HUMAN 5NKBA 1.5 Inactive DFGin BLBminus in-in out-in 8ZT Type1 605 - 896 None None 2
Homo sapiens EPHA2_HUMAN 5NKCA 1.448 Inactive DFGin BLBminus in-in out-in 90T Type1 601 - 896 None None 5
Homo sapiens EPHA2_HUMAN 5NKDA 1.408 Inactive DFGin BLBminus in-in out-in 91K Type1 600 - 896 None None 4
Homo sapiens EPHA2_HUMAN 5NKEA 1.39 Inactive DFGin BLBminus in-in out-in 90B Type1 605 - 896 None None 0
Homo sapiens EPHA2_HUMAN 5NKFA 1.099 Inactive DFGin BLBminus in-out out-in 8ZN Type1 605 - 896 None None 0
Homo sapiens EPHA2_HUMAN 5NKGA 1.1 Inactive DFGin BLBminus in-out out-in 8ZK Type1 605 - 896 None None 0
Homo sapiens EPHA2_HUMAN 5NKHA 1.29 Inactive DFGin BLBminus in-in out-in 8ZQ Type1 601 - 895 None None 0
Homo sapiens EPHA2_HUMAN 5NKIA 1.675 Inactive DFGin BLBminus in-in none-none 8ZW Type1 604 - 896 None None 20
Homo sapiens EPHA2_HUMAN 8BK0A 1.7 Inactive DFGin BLBminus in-in out-in QJI Type1 605 - 887 None None 11
Homo sapiens EPHA2_HUMAN 7KJCA 2.3 Inactive DFGin BLBminus in-in out-in ACP Type1 590 - 976 S901E None 5
Homo sapiens EPHA2_HUMAN 7KJCB 2.3 Inactive DFGin BLBminus in-in none-none ACP Type1 590 - 965 S901E None 20
Homo sapiens EPHA2_HUMAN 7KJAA 1.75 Inactive DFGin BLBminus in-in none-none ACP Type1 590 - 976 None None 20
Homo sapiens EPHA2_HUMAN 5IA2A 1.619 Inactive DFGin BLBminus in-out out-in L66 Type1.5_Back 598 - 888 None None 0
Homo sapiens EPHA2_HUMAN 4PDOA 2.104 Inactive DFGin None in-out none-in No_ligand No_ligand 590 - 875 None None 18
Homo sapiens EPHA2_HUMAN 4PDOB 2.104 Inactive DFGin None in-out none-in No_ligand No_ligand 590 - 875 None None 18
Homo sapiens EPHA2_HUMAN 5IA1A 2.036 Inactive DFGin None in-in none-in ZZL Type1 605 - 888 None None 17
Homo sapiens EPHA2_HUMAN 8XPVA 1.55 Inactive DFGout BBAminus in-in none-in 4Z5 Type2 604 - 895 None None 19
Homo sapiens EPHA2_HUMAN 6FNFA 1.556 Inactive DFGout BBAminus in-in none-none DXH Type2 606 - 894 None None 18
Homo sapiens EPHA2_HUMAN 6FNGA 1.038 Inactive DFGout BBAminus in-in none-in DWT Type2 599 - 897 None None 17
Homo sapiens EPHA2_HUMAN 6HESA 1.128 Inactive DFGout BBAminus in-in none-none G0H Type2 599 - 896 None None 18
Homo sapiens EPHA2_HUMAN 6HETA 1.208 Inactive DFGout BBAminus in-in none-none G0Q Type2 605 - 896 None None 19
Homo sapiens EPHA2_HUMAN 6HEUA 1.719 Inactive DFGout BBAminus in-in none-none G0N Type2 600 - 896 None None 18
Homo sapiens EPHA2_HUMAN 6HEVA 1.28 Inactive DFGout BBAminus in-in none-in G0K Type2 600 - 896 None None 17
Homo sapiens EPHA2_HUMAN 6HEWA 1.268 Inactive DFGout BBAminus in-in none-out G0E Type2 605 - 896 None None 15
Homo sapiens EPHA2_HUMAN 6HEXA 1.413 Inactive DFGout BBAminus in-in none-none G02 Type2 605 - 896 None None 19
Homo sapiens EPHA2_HUMAN 6HEYA 1.367 Inactive DFGout BBAminus in-in none-out FZW Type2 600 - 896 None None 16
Homo sapiens EPHA2_HUMAN 6Q7BA 1.009 Inactive DFGout BBAminus in-in none-out HO5 Type2 599 - 896 None None 15
Homo sapiens EPHA2_HUMAN 6Q7CA 1.049 Inactive DFGout BBAminus in-in none-out HOK Type2 599 - 896 None None 15
Homo sapiens EPHA2_HUMAN 6Q7DA 0.978 Inactive DFGout BBAminus in-in none-out HOT Type2 600 - 896 None None 18
Homo sapiens EPHA2_HUMAN 6Q7EA 1.059 Inactive DFGout BBAminus in-in none-none HMW Type2 601 - 896 None None 19
Homo sapiens EPHA2_HUMAN 6Q7GA 1.047 Inactive DFGout BBAminus in-in none-none HO8 Type2 601 - 896 None None 19
Homo sapiens EPHA2_HUMAN 8BOCA 1.9 Inactive DFGout BBAminus in-in out-in QUF Type2 605 - 888 None None 0
Homo sapiens EPHA2_HUMAN 8BODA 1.5 Inactive DFGout BBAminus in-in none-none QTX Type2 605 - 896 None None 19
Homo sapiens EPHA2_HUMAN 8BOGA 1.47 Inactive DFGout BBAminus in-in none-none QUU Type2 600 - 895 None None 19
Homo sapiens EPHA2_HUMAN 8BOHA 1.42 Inactive DFGout BBAminus in-in none-out R0T Type2 604 - 896 None None 18
Homo sapiens EPHA2_HUMAN 8BOIA 1.63 Inactive DFGout BBAminus in-in none-out R0O Type2 604 - 896 None None 18
Homo sapiens EPHA2_HUMAN 8BOKA 2.02 Inactive DFGout BBAminus in-in out-in R0X Type2 605 - 890 None None 0
Homo sapiens EPHA2_HUMAN 8BOMA 1.12 Inactive DFGout BBAminus in-in none-none QU6 Type2 605 - 896 None None 19
Homo sapiens EPHA2_HUMAN 5IA4A 1.797 Inactive DFGout None in-out out-in 88Z Type2 605 - 877 None None 0
Homo sapiens EPHA2_HUMAN 5IA5A 1.776 Inactive DFGout None in-out out-in GV0 Type2 605 - 880 None None 0
Homo sapiens EPHA2_HUMAN 6Q7FA 1.204 Inactive DFGout None in-in none-none HNZ Type2 605 - 896 None None 20
Homo sapiens EPHA2_HUMAN 8BOFA 1.82 Inactive DFGout None in-in none-none R3L Type2 605 - 896 None None 21

EPHA2 (Ephrin type-A receptor 2)

No non-human structures known.