4MNE

MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)
BRAF (Serine/threonine-protein kinase B-raf)
Group: TKL STE
Uniprot: BRAF_HUMAN MP2K1_HUMAN
Organism: Homo sapiens
Domain boundary: 68 - 361 457 - 716
Resolution: 2.848

Chain id Group Gene UniprotID Protein Organism Activity Spatial Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens Inactive DFGin BLBplus out-out out-out ACP 573 Type1 Type1 63 - 379 0
D STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens Inactive DFGin BLBplus out-out out-out ACP 573 Type1 Type1 66 - 382 0
E STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens Inactive DFGin BLBplus out-out out-out ACP 573 Type1 Type3 62 - 379 0
H STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens Inactive DFGin BLBplus out-out out-out ACP 573 573 Type1 Type3 Allosteric 66 - 380 0
B TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf Homo sapiens Active DFGin BLAminus in-in in-in No_ligand No_ligand 449 - 722 0
C TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf Homo sapiens Active DFGin BLAminus in-in in-in No_ligand No_ligand 449 - 720 7
F TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf Homo sapiens Active DFGin BLAminus in-in in-in No_ligand No_ligand 449 - 721 9
G TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf Homo sapiens Active DFGin BLAminus in-in in-in No_ligand No_ligand 449 - 720 8
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain G
         -        439        449        459 
mdrgshhhhh hgsedrnrmk tlgrrdssdD WEIPDGQITV 
       469        479        489        499 
GQRIgsgsfG TVYKGKWHGD VAVKMLNVTA PTPQQLQAFK 
       509        519        529        539 
NEVGVLRKTR HVNILLFMGY STKPQLAIVT QWCEGSSLYH 
       549        559        569        579 
HLHIIETKFE MIKLIDIARQ TAQGMDYLHA KSIIHRDLKS 
       589        599        609        619 
NNIFLHEDLT VKIGDFGLAT VKSrwsgshq fEQLSGSILW 
       629        639        649        659 
MAPEVIRMQD KNPYSFQSDV YAFGIVLYEL MTGQLPYSNI 
       669        679        689        699 
NNRDQIIFMV GRGYLSPDLS KVRSNCPKAM KRLMAECLKK 
       709        719 
KRDERPLFPQ ILASIELLAR Slpkihrk
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None