4XLV

INSR (Insulin receptor)
Group: TYR
Uniprot: INSR_HUMAN
Organism: Homo sapiens
Domain boundary: 1023 - 1292
Resolu: 2.3

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in ACP Type1 1001 - 1310 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
       992       1002       1012       1022 
qpdgplgplf assnpeylSA SDVFPSSVYV PDEWEVSREK 
      1032       1042       1052       1062 
ITLLRELGQG SFGMVYEGNA RDIIKGEAET RVAVKTVNES 
      1072       1082       1092       1102 
ASLRERIEFL NEASVMKGFT CHHVVRLLGV VSKGQPTLVV 
      1112       1122       1132       1142 
MELMAHGDLK SYLRSLRPEA ENNPGRPPPT LQEMIQMAAE 
      1152       1162       1172       1182 
IADGMAYLNA KKFVHRDLAA RNCMVAHDFT VKIGDFGMTR 
      1192       1202       1212       1222 
DIYETDYYRK GGKGLLPVRW MAPESLKDGV FTTSSDMWSF 
      1232       1242       1252       1262 
GVVLWEITSL AEQPYQGLSN EQVLKFVMDG GYLDQPDNCP 
      1272       1282       1292       1302 
ERVTDLMRMC WQFNPNMRPT FLEIVNLLKD DLHPSFPEVS 

FFHSEENK
Lower-case residues are disordered in structure.
Mutations: Y992F,C1008S
Phosphorylation: X999,X1185,X1189,X1190