5UHN

FGFR2 (Fibroblast growth factor receptor 2)
Group: TYR
Uniprot: FGFR2_HUMAN
Organism: Homo sapiens
Domain boundary: 481 - 759
Resolu: 2.909

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in ACP Type1 469 - 764 0
B Active DFGin BLAminus in-in in-in ACP Type1 469 - 764 11
Representative sequence - Chain B
- 464 474 484
mgsshhhhhh sqdpmlagvs eyelPEDPKW EFPRDKLTLG
494 504 514 524
KPLGEGAFGQ VVMAEAVGID KDKPKEAVTV AVKMLKDDAT
534 544 554 564
EKDLSDLVSE MEMMKMIGKH KNIIHLLGAC TQDGPLYVIV
574 584 594 604
AYASKGNLRE YLRARRppgm eysydinrvp eeQMTFKDLV
614 624 634 644
SCTYQLARGM EYLASQKCIH RDLAARNVLV TENNVMKIAD
654 664 674 684
FGLARDInni dyykkttnGR LPVKWMAPEA LFDRVYTHQS
694 704 714 724
DVWSFGVLMW EIFTLGGSPY PGIPVEELFK LLKEGHRMDK
734 744 754 764
PANCTNELYM MMRDCWHAVP SQRPTFKQLV EDLDRILTLT

tnee
Lower-case residues are disordered in structure.
Mutations: N549H,E565A
Phosphorylation: None