4ANB

MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)
Group: STE
Uniprot: MP2K1_HUMAN
Organism: Homo sapiens
Domain boundary: 68 - 361
Resolu: 2.2

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLBplus out-out out-out YQY ACP Type3 Type1 61 - 381 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
        67         77         87         97 
MALGELKDDD FEKISELGAG NGGVVFKVSH KPSGLVMARK 
       107        117        127        137 
LIHLEIKPAI RNQIIRELQV LHECNSPYIV GFYGAFYSDG 
       147        157        167        177 
EISICMEHMD GGSLDQVLKK AGRIPEQILG KVSIAVIKGL 
       187        197        207        217 
TYLREKHKIM HRDVKPSNIL VNSRGEIKLC DFGVSGQLID 
       227        237        247        257 
EMANEFVGTR SYMSPERLQG THYSVQSDIW SMGLSLVEMA 
       309        319        329        339 
VGRYPRPPMA IFELLDYIVN EPPPKLPSAV FSLEFQDFVN 
       349        359        369        379 
KCLIKNPAER ADLKQLMVHA FIKRSDAEEV DFAGWLCSTI 
       389          - 
GLnqpstpth aageghhhhh h
Lower-case residues are disordered in structure.
Mutations: S218E,S222E,G328A
Phosphorylation: None