MAPK1 (Mitogen-activated protein kinase 1)

Group: CMGC
Uniprot: MK01_HUMAN
Domain boundary: 25 - 313


Total number of chains: 162
Spatial Dihedral Chains Representative
DFGin BLAminus 160 AF-P28482-K1A
DFGin ABAminus 2 1WZYA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
1WZYA 2.5 Inactive DFGin ABAminus in-in in-out F29 Type1 8 - 357 None None 0
1TVOA 2.5 Inactive DFGin ABAminus in-in in-in FRZ Type1 8 - 357 None None 0
7W5OB 2.35 Active DFGin BLAminus in-in in-in 6GI Allosteric 12 - 357 None None 0
6QAHA 1.58 Inactive DFGin BLAminus in-out in-in HVB HVB Allosteric Allosteric 11 - 357 None None 0
6QALA 1.57 Active DFGin BLAminus in-in in-in HV2 HV2 Allosteric Allosteric 11 - 357 None None 0
6NBSA 1.9 Inactive DFGin BLAminus out-out in-in KJ7 KJ4 Allosteric Allosteric 10 - 356 None None 0
8AOGA 1.603 Active DFGin BLAminus in-in in-in N29 N29 N29 Allosteric Allosteric Type1 11 - 356 None None 0
6G8XA 1.76 Active DFGin BLAminus out-in in-in EQT EQT Allosteric Type1 11 - 357 None None 0
6QA1A 1.58 Inactive DFGin BLAminus out-out in-in HVK HVK HVK HVK HVK HVK HVK Allosteric Type1 Allosteric Allosteric Allosteric Allosteric Allosteric 11 - 358 None None 0
6QA4A 1.6 Inactive DFGin BLAminus out-out in-in HRZ HRZ HRZ HRZ Allosteric Type1 Allosteric Type3 11 - 357 None None 0
AF-P28482-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 17 - 321 None None 0
4IZ7A 1.8 Inactive DFGin BLAminus out-in in-out No_ligand No_ligand 11 - 360 None None 6
4IZ7C 1.8 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 11 - 359 None None 9
4IZAA 1.93 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 11 - 358 None X185,X187 0
4IZAC 1.93 None DFGin BLAminus out-none in-none No_ligand No_ligand 11 - 358 None X185,X187 13
5V61A 2.2 Active DFGin BLAminus in-in in-in No_ligand No_ligand 10 - 359 None X185,X187 0
6Q7SA 1.73 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 11 - 356 None None 0
6QA3A 1.57 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 8 - 357 None None 0
4QP2B 2.23 Active DFGin BLAminus in-in in-in No_ligand No_ligand 12 - 357 None None 3
7E73A 2.28 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 11 - 357 Y36H None 0
7E75A 2.481 Active DFGin BLAminus out-in in-in No_ligand No_ligand 10 - 358 G37C None 0
6D5YA 2.86 Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 13 - 357 G169D None 8
1PMEA 2.0 Active DFGin BLAminus out-in in-in SB2 Type1 16 - 360 I103L,Q105T,D106H,E109G,T110A None 0
6DMGA 2.2 Active DFGin BLAminus in-in in-in EK6 Type1 11 - 357 None None 0
4XJ0A 2.58 Active DFGin BLAminus in-in in-in 41B Type1 12 - 360 None None 0
4XJ0B 2.58 Active DFGin BLAminus in-in in-in 41B Type1 12 - 357 None None 0
5K4IA 1.76 None DFGin BLAminus in-in in-none 6QB Type1 9 - 358 None None 14
4H3QA 2.2 Inactive DFGin BLAminus in-in in-out ANP Type1 9 - 360 R77A,C161S,I255G,E314A None 0
6OPGA 2.9 Active DFGin BLAminus in-in in-in ANP Type1 10 - 358 None X185,X187 0
6OPHA 2.4 Active DFGin BLAminus in-in in-in 6QB Type1 11 - 358 None X185,X187 0
8U8JA 2.1 Active DFGin BLAminus in-in in-in WAL Type1 7 - 358 A7S X185,X187 0
8U8KA 2.1 Active DFGin BLAminus in-in in-in W8U Type1 10 - 358 A7S X185,X187 0
5V60A 2.18 Active DFGin BLAminus in-in in-in ACP Type1 10 - 358 None X185,X187 0
4IZ5A 3.19 Inactive DFGin BLAminus in-out in-out ADP Type1 11 - 357 T185E None 0
4IZ5B 3.19 Inactive DFGin BLAminus in-out in-out ADP Type1 11 - 357 T185E None 0
4IZ5C 3.19 Inactive DFGin BLAminus in-out in-out ADP Type1 11 - 357 T185E None 0
4IZ5D 3.19 Inactive DFGin BLAminus in-out in-out ADP Type1 11 - 357 T185E None 0
3SA0A 1.595 Active DFGin BLAminus out-in in-in NRA Type1 4 - 360 None None 0
4FUXA 2.2 Inactive DFGin BLAminus out-out in-in E75 Type1 11 - 357 None None 0
4FUYA 2.0 Inactive DFGin BLAminus out-out in-in EK2 Type1 11 - 358 None None 0
4FV0A 2.1 Inactive DFGin BLAminus out-out in-in EK3 Type1 11 - 358 None None 0
4FV1A 1.99 Active DFGin BLAminus in-in in-in EK4 Type1 11 - 356 None None 0
4FV2A 2.0 Active DFGin BLAminus in-in in-in EK5 Type1 11 - 357 None None 0
4FV3A 2.2 Active DFGin BLAminus in-in in-in EK6 Type1 11 - 357 None None 0
4FV4A 2.5 Active DFGin BLAminus in-in in-in EK7 Type1 9 - 357 None None 12
4FV5A 2.4 Active DFGin BLAminus in-in in-in EK9 Type1 9 - 357 None None 14
4FV6A 2.5 Active DFGin BLAminus in-in in-in E57 Type1 9 - 357 None None 14
4FV7A 1.9 Active DFGin BLAminus in-in in-in E94 Type1 11 - 358 None None 0
4FV8A 2.0 Active DFGin BLAminus in-in in-in E63 Type1 8 - 357 None None 13
4FV9A 2.11 Active DFGin BLAminus in-in in-in E71 Type1 8 - 357 None None 14
4G6NA 2.0 Inactive DFGin BLAminus out-out in-in EK0 Type1 11 - 358 None None 0
4G6OA 2.2 Active DFGin BLAminus in-in in-in E28 Type1 11 - 357 None None 0
4N0SA 1.799 Active DFGin BLAminus in-in in-in DHC Type1 6 - 357 None None 0
4ZXTA 2.0 Active DFGin BLAminus in-in in-in CAQ Type1 7 - 357 None None 0
5LCKA 1.89 Active DFGin BLAminus out-in in-in 6TT Type1 11 - 357 None None 0
4QTEA 1.5 Active DFGin BLAminus in-in in-in 390 Type1 11 - 358 None None 0
6G54A 2.05 Active DFGin BLAminus out-in in-in 6H3 Type1 10 - 356 None None 0
5BUEA 2.4 None DFGin BLAminus in-in in-none 4V8 Type1 11 - 358 None None 15
5BUIA 2.12 None DFGin BLAminus in-in in-none 4V9 Type1 11 - 358 None None 10
5BUJA 1.85 None DFGin BLAminus in-in in-none 4VB Type1 9 - 358 None None 15
5BVDA 1.9 None DFGin BLAminus in-in in-none 4VF Type1 9 - 358 None None 16
5BVEA 2.0 None DFGin BLAminus in-in in-none 4VG Type1 9 - 358 None None 16
5BVFA 1.9 None DFGin BLAminus in-in in-none 4VJ Type1 9 - 358 None None 17
2Y9QA 1.55 Inactive DFGin BLAminus in-in in-out ANP Type1 9 - 358 None None 0
4FMQA 2.098 Inactive DFGin BLAminus in-in in-out ANP Type1 9 - 358 None None 0
4NIFB 2.15 Inactive DFGin BLAminus in-in in-out ANP Type1 9 - 360 None None 3
4NIFE 2.15 Inactive DFGin BLAminus in-in in-out ANP Type1 10 - 360 None None 3
7OPMA 2.45 Active DFGin BLAminus in-in in-in 08G Type1 1 - 360 None X185,X187 0
5LCJA 1.78 Active DFGin BLAminus in-in in-in 6TS Type1 11 - 357 None None 0
6G91A 1.8 Active DFGin BLAminus in-in in-in EQW Type1 8 - 357 None None 0
6G92A 1.99 Active DFGin BLAminus out-in in-in ERZ Type1 8 - 357 None None 0
6G93A 1.67 Active DFGin BLAminus in-in in-in EU2 Type1 11 - 357 None None 0
6G97A 1.9 Active DFGin BLAminus in-in in-in EQZ Type1 11 - 357 None None 0
6G9AA 1.91 Active DFGin BLAminus in-in in-in ESQ Type1 8 - 357 None None 0
6G9MA 1.86 Active DFGin BLAminus in-in in-in ESW Type1 11 - 356 None None 0
6GDQA 1.86 Active DFGin BLAminus in-in in-in EVK Type1 10 - 357 None None 0
6GJBA 1.82 Active DFGin BLAminus in-in in-in F0H Type1 8 - 357 None None 0
6Q7KA 1.84 Inactive DFGin BLAminus out-out in-in 2AI Type1 8 - 357 None None 0
6QAWA 1.84 Active DFGin BLAminus out-in in-in HVE Type1 11 - 357 None None 0
6RQ4A 1.96 Active DFGin BLAminus out-in in-in KE8 Type1 19 - 357 None None 0
7NR3A 1.897 Active DFGin BLAminus in-in in-in UO5 Type1 11 - 356 None None 0
8AO2A 1.796 Active DFGin BLAminus out-in in-in NXI Type1 13 - 357 None None 0
8AO3A 1.778 Active DFGin BLAminus out-in in-in NYX Type1 11 - 357 None None 0
8AO4A 1.825 Active DFGin BLAminus out-in in-in N8U Type1 11 - 357 None None 0
8AO5A 1.595 Active DFGin BLAminus out-in in-in N6K Type1 15 - 356 None None 0
8AO6A 1.811 Active DFGin BLAminus out-in in-in N9F Type1 11 - 356 None None 0
8AO7A 1.61 Active DFGin BLAminus out-in in-in N3X Type1 11 - 356 None None 0
8AO8A 1.697 Active DFGin BLAminus out-in in-in N5U Type1 11 - 356 None None 0
8AO9A 1.624 Inactive DFGin BLAminus out-out in-in N4F Type1 11 - 356 None None 0
8AOBA 1.623 Active DFGin BLAminus out-in in-in NB3 Type1 18 - 356 None None 0
8AOCA 1.62 Active DFGin BLAminus out-in in-in N3O Type1 11 - 356 None None 0
8AOEA 1.687 Active DFGin BLAminus out-in in-in N6U Type1 11 - 356 None None 0
8AOFA 1.615 Active DFGin BLAminus out-in in-in N4U Type1 11 - 356 None None 0
8AOJA 1.12 Active DFGin BLAminus in-in in-in N8L Type1 10 - 356 None None 0
3W55A 3.0 Inactive DFGin BLAminus in-in in-out 1FM Type1 11 - 357 None None 12
5AX3A 2.984 None DFGin BLAminus out-out in-none 5ID Type1 10 - 358 None None 9
7W5OA 2.35 Inactive DFGin BLAminus in-out in-in 5ID Type1 11 - 360 None None 0
7XC1B 2.09 Active DFGin BLAminus in-in in-in 5ID Type1 12 - 357 None None 0
4O6EA 1.95 Inactive DFGin BLAminus in-in in-out 2SH Type1 13 - 357 None None 11
4QP1A 2.7 Inactive DFGin BLAminus out-out in-in EMU Type1 12 - 360 None None 0
4QP1B 2.7 Inactive DFGin BLAminus in-out in-in EMU Type1 12 - 357 None None 0
4QP2A 2.23 Active DFGin BLAminus in-in in-in 36R Type1 12 - 360 None None 6
4QP3A 2.599 Active DFGin BLAminus in-in in-in 36Q Type1 12 - 360 None None 6
4QP3B 2.599 Active DFGin BLAminus in-in in-in 36Q Type1 12 - 357 None None 3
4QP4A 2.2 Inactive DFGin BLAminus in-out in-out 36O Type1 13 - 357 None None 8
4QP4B 2.2 Inactive DFGin BLAminus in-out in-out 36O Type1 12 - 357 None None 11
4QP6A 3.1 Active DFGin BLAminus in-in in-in 36N Type1 12 - 360 None None 6
4QP6B 3.1 Active DFGin BLAminus in-in in-in 36N Type1 12 - 357 None None 3
4QP7A 2.249 Inactive DFGin BLAminus in-in in-out 363 Type1 13 - 357 None None 8
4QP7B 2.249 Inactive DFGin BLAminus in-out in-out 363 Type1 12 - 357 None None 11
4QP8A 2.446 Inactive DFGin BLAminus in-in in-out 362 Type1 12 - 357 None None 11
4QP8B 2.446 Inactive DFGin BLAminus in-in in-out 362 Type1 13 - 357 None None 8
4QP9A 2.001 Inactive DFGin BLAminus in-in in-out 35X Type1 13 - 357 None None 8
4QPAA 2.85 Inactive DFGin BLAminus in-out in-in 35W Type1 12 - 357 None None 3
4QPAB 2.85 Active DFGin BLAminus out-in in-in 35W Type1 12 - 360 None None 2
4ZZMA 1.89 Inactive DFGin BLAminus in-out in-in CQ6 Type1 11 - 355 None None 0
4ZZNA 1.33 Active DFGin BLAminus in-in in-in CQ8 Type1 11 - 355 None None 0
4ZZOA 1.63 Active DFGin BLAminus in-in in-in CQ3 Type1 11 - 355 None None 0
3TEIA 2.404 Inactive DFGin BLAminus in-in in-out ANP Type1 10 - 358 R77A,E314A None 7
4H3PA 2.3 Inactive DFGin BLAminus in-in in-out ANP Type1 11 - 359 R77A,E314A None 7
4H3PD 2.3 None DFGin BLAminus in-in in-none ANP Type1 11 - 359 R77A,E314A None 11
2OJGA 2.0 Active DFGin BLAminus in-in in-in 19A Type1 19 - 357 None None 0
2OJIA 2.6 Active DFGin BLAminus out-in in-in 33A Type1 15 - 358 None None 0
2OJJA 2.4 Active DFGin BLAminus in-in in-in 82A Type1 15 - 358 None None 0
3I5ZA 2.2 Active DFGin BLAminus in-in in-in Z48 Type1 8 - 357 None None 14
3I60A 2.5 Active DFGin BLAminus in-in in-in E86 Type1 8 - 358 None None 13
5NGUA 2.74 Active DFGin BLAminus in-in in-in 8X2 Type1 11 - 355 None None 0
5NHFA 2.14 Inactive DFGin BLAminus in-out in-in 8X5 Type1 12 - 355 None None 0
5NHHA 1.94 Active DFGin BLAminus in-in in-in 8XH Type1 11 - 358 None None 0
5NHJA 2.12 Active DFGin BLAminus in-in in-in 8XE Type1 11 - 355 None None 0
5NHLA 2.07 Active DFGin BLAminus in-in in-in 8XB Type1 11 - 355 None None 0
5NHOA 2.24 Active DFGin BLAminus in-in in-in 8XN Type1 11 - 355 None None 0
5NHPA 1.99 Active DFGin BLAminus in-in in-in 8XK Type1 11 - 355 None None 0
5NHVA 2.0 Active DFGin BLAminus in-in in-in 8QB Type1 11 - 355 None None 0
6SLGA 1.33 Active DFGin BLAminus in-in in-in LHZ Type1 18 - 356 None None 0
5WP1A 1.4 Inactive DFGin BLAminus out-out in-in B7S BEZ Type1 Allosteric 15 - 357 None None 0
6Q7TA 1.6 Inactive DFGin BLAminus in-out in-in HOW HOW Type1 Allosteric 11 - 356 None None 0
6QAGA 2.07 Inactive DFGin BLAminus out-out in-in HUH HUH Type1 Allosteric 11 - 357 None None 0
8AOAA 1.62 Active DFGin BLAminus out-in in-in N83 OZU Type1 Allosteric 11 - 356 None None 0
8AODA 1.62 Active DFGin BLAminus in-in in-in NY0 NYI Type1 Allosteric 11 - 356 None None 0
8AOHA 1.6 Active DFGin BLAminus out-in in-in N96 N96 Type1 Allosteric 11 - 356 None None 0
8AOIA 1.602 Active DFGin BLAminus out-in in-in NX0 NX0 Type1 Allosteric 11 - 356 None None 0
7XC1A 2.09 Active DFGin BLAminus in-in in-in 5ID B8Z Type1 Allosteric 10 - 360 None None 0
7X4UA 1.98 Inactive DFGin BLAminus in-out in-in 5ID 8DK BTB Type1 Allosteric Allosteric 10 - 359 None None 0
5V62A 1.9 Active DFGin BLAminus in-in in-in FRZ AKS Type1 Type1 10 - 360 None X185,X187 0
6OPIA 3.0 None DFGin BLAminus in-in in-none N0V Type1.5_Front 10 - 356 None X185,X187 12
4QTAA 1.45 None DFGin BLAminus in-in in-none 38Z Type1.5_Front 10 - 358 None None 14
6G9DA 1.8 Active DFGin BLAminus in-in in-in ER8 Type1.5_Front 8 - 357 None None 0
6G9HA 1.73 Active DFGin BLAminus out-in in-in ERW Type1.5_Front 11 - 357 None None 0
6G9JA 1.98 Active DFGin BLAminus in-in in-in ERK Type1.5_Front 8 - 357 None None 0
6G9KA 1.94 Active DFGin BLAminus in-in in-in ESK Type1.5_Front 11 - 357 None None 0
6G9NA 1.76 Active DFGin BLAminus out-in in-in ESN Type1.5_Front 11 - 357 None None 0
6GDMA 1.91 Active DFGin BLAminus in-in in-in F3Z Type1.5_Front 8 - 356 None None 0
6GE0A 1.82 Active DFGin BLAminus in-in in-in EVQ Type1.5_Front 11 - 357 None None 0
6GJDA 1.58 Active DFGin BLAminus in-in in-in F0E Type1.5_Front 10 - 357 None None 0
7AUVA 1.76 Active DFGin BLAminus out-in in-in RYW Type1.5_Front 11 - 357 None None 0
7NQQA 1.943 Active DFGin BLAminus in-in in-in UMN Type1.5_Front 11 - 356 None None 0
7NQWA 1.775 Active DFGin BLAminus in-in in-in UNW Type1.5_Front 11 - 356 None None 0
7NR5A 1.766 Active DFGin BLAminus out-in in-in UOH Type1.5_Front 11 - 357 None None 0
7NR8A 1.627 Active DFGin BLAminus in-in in-in UOE Type1.5_Front 11 - 356 None None 0
7NR9A 1.906 Active DFGin BLAminus out-in in-in UOW Type1.5_Front 11 - 355 None None 0
6QAQA 1.58 Inactive DFGin BLAminus out-out in-in HVQ HVQ Type3 Allosteric 11 - 357 None None 0

MAPK1 (Mitogen-activated protein kinase 1)

Group: CMGC
Total number of chains: 226
Spatial Dihedral Chains Representative
DFGin BLAminus 221 AF-P28482-K1A
DFGin ABAminus 2 1WZYA
DFGin None 2 6FJZA
DFGout None 1 4I5HA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens MK01_HUMAN 1WZYA 2.5 Inactive DFGin ABAminus in-in in-out F29 Type1 8 - 357 None None 0
Homo sapiens MK01_HUMAN 1TVOA 2.5 Inactive DFGin ABAminus in-in in-in FRZ Type1 8 - 357 None None 0
Homo sapiens MK01_HUMAN 7W5OB 2.35 Active DFGin BLAminus in-in in-in 6GI Allosteric 12 - 357 None None 0
Homo sapiens MK01_HUMAN 6QAHA 1.58 Inactive DFGin BLAminus in-out in-in HVB HVB Allosteric Allosteric 11 - 357 None None 0
Homo sapiens MK01_HUMAN 6QALA 1.57 Active DFGin BLAminus in-in in-in HV2 HV2 Allosteric Allosteric 11 - 357 None None 0
Homo sapiens MK01_HUMAN 6NBSA 1.9 Inactive DFGin BLAminus out-out in-in KJ7 KJ4 Allosteric Allosteric 10 - 356 None None 0
Homo sapiens MK01_HUMAN 8AOGA 1.603 Active DFGin BLAminus in-in in-in N29 N29 N29 Allosteric Allosteric Type1 11 - 356 None None 0
Homo sapiens MK01_HUMAN 6G8XA 1.76 Active DFGin BLAminus out-in in-in EQT EQT Allosteric Type1 11 - 357 None None 0
Homo sapiens MK01_HUMAN 6QA1A 1.58 Inactive DFGin BLAminus out-out in-in HVK HVK HVK HVK HVK HVK HVK Allosteric Type1 Allosteric Allosteric Allosteric Allosteric Allosteric 11 - 358 None None 0
Homo sapiens MK01_HUMAN 6QA4A 1.6 Inactive DFGin BLAminus out-out in-in HRZ HRZ HRZ HRZ Allosteric Type1 Allosteric Type3 11 - 357 None None 0
Homo sapiens MK01_HUMAN AF-P28482-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 17 - 321 None None 0
Homo sapiens MK01_HUMAN 4IZ7A 1.8 Inactive DFGin BLAminus out-in in-out No_ligand No_ligand 11 - 360 None None 6
Homo sapiens MK01_HUMAN 4IZ7C 1.8 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 11 - 359 None None 9
Homo sapiens MK01_HUMAN 4IZAA 1.93 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 11 - 358 None X185,X187 0
Homo sapiens MK01_HUMAN 4IZAC 1.93 None DFGin BLAminus out-none in-none No_ligand No_ligand 11 - 358 None X185,X187 13
Homo sapiens MK01_HUMAN 5V61A 2.2 Active DFGin BLAminus in-in in-in No_ligand No_ligand 10 - 359 None X185,X187 0
Homo sapiens MK01_HUMAN 6Q7SA 1.73 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 11 - 356 None None 0
Homo sapiens MK01_HUMAN 6QA3A 1.57 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 8 - 357 None None 0
Homo sapiens MK01_HUMAN 4QP2B 2.23 Active DFGin BLAminus in-in in-in No_ligand No_ligand 12 - 357 None None 3
Homo sapiens MK01_HUMAN 7E73A 2.28 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 11 - 357 Y36H None 0
Homo sapiens MK01_HUMAN 7E75A 2.481 Active DFGin BLAminus out-in in-in No_ligand No_ligand 10 - 358 G37C None 0
Homo sapiens MK01_HUMAN 6D5YA 2.86 Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 13 - 357 G169D None 8
Homo sapiens MK01_HUMAN 1PMEA 2.0 Active DFGin BLAminus out-in in-in SB2 Type1 16 - 360 I103L,Q105T,D106H,E109G,T110A None 0
Homo sapiens MK01_HUMAN 6DMGA 2.2 Active DFGin BLAminus in-in in-in EK6 Type1 11 - 357 None None 0
Homo sapiens MK01_HUMAN 4XJ0A 2.58 Active DFGin BLAminus in-in in-in 41B Type1 12 - 360 None None 0
Homo sapiens MK01_HUMAN 4XJ0B 2.58 Active DFGin BLAminus in-in in-in 41B Type1 12 - 357 None None 0
Homo sapiens MK01_HUMAN 5K4IA 1.76 None DFGin BLAminus in-in in-none 6QB Type1 9 - 358 None None 14
Homo sapiens MK01_HUMAN 4H3QA 2.2 Inactive DFGin BLAminus in-in in-out ANP Type1 9 - 360 R77A,C161S,I255G,E314A None 0
Homo sapiens MK01_HUMAN 6OPGA 2.9 Active DFGin BLAminus in-in in-in ANP Type1 10 - 358 None X185,X187 0
Homo sapiens MK01_HUMAN 6OPHA 2.4 Active DFGin BLAminus in-in in-in 6QB Type1 11 - 358 None X185,X187 0
Homo sapiens MK01_HUMAN 8U8JA 2.1 Active DFGin BLAminus in-in in-in WAL Type1 7 - 358 A7S X185,X187 0
Homo sapiens MK01_HUMAN 8U8KA 2.1 Active DFGin BLAminus in-in in-in W8U Type1 10 - 358 A7S X185,X187 0
Homo sapiens MK01_HUMAN 5V60A 2.18 Active DFGin BLAminus in-in in-in ACP Type1 10 - 358 None X185,X187 0
Homo sapiens MK01_HUMAN 4IZ5A 3.19 Inactive DFGin BLAminus in-out in-out ADP Type1 11 - 357 T185E None 0
Homo sapiens MK01_HUMAN 4IZ5B 3.19 Inactive DFGin BLAminus in-out in-out ADP Type1 11 - 357 T185E None 0
Homo sapiens MK01_HUMAN 4IZ5C 3.19 Inactive DFGin BLAminus in-out in-out ADP Type1 11 - 357 T185E None 0
Homo sapiens MK01_HUMAN 4IZ5D 3.19 Inactive DFGin BLAminus in-out in-out ADP Type1 11 - 357 T185E None 0
Homo sapiens MK01_HUMAN 3SA0A 1.595 Active DFGin BLAminus out-in in-in NRA Type1 4 - 360 None None 0
Homo sapiens MK01_HUMAN 4FUXA 2.2 Inactive DFGin BLAminus out-out in-in E75 Type1 11 - 357 None None 0
Homo sapiens MK01_HUMAN 4FUYA 2.0 Inactive DFGin BLAminus out-out in-in EK2 Type1 11 - 358 None None 0
Homo sapiens MK01_HUMAN 4FV0A 2.1 Inactive DFGin BLAminus out-out in-in EK3 Type1 11 - 358 None None 0
Homo sapiens MK01_HUMAN 4FV1A 1.99 Active DFGin BLAminus in-in in-in EK4 Type1 11 - 356 None None 0
Homo sapiens MK01_HUMAN 4FV2A 2.0 Active DFGin BLAminus in-in in-in EK5 Type1 11 - 357 None None 0
Homo sapiens MK01_HUMAN 4FV3A 2.2 Active DFGin BLAminus in-in in-in EK6 Type1 11 - 357 None None 0
Homo sapiens MK01_HUMAN 4FV4A 2.5 Active DFGin BLAminus in-in in-in EK7 Type1 9 - 357 None None 12
Homo sapiens MK01_HUMAN 4FV5A 2.4 Active DFGin BLAminus in-in in-in EK9 Type1 9 - 357 None None 14
Homo sapiens MK01_HUMAN 4FV6A 2.5 Active DFGin BLAminus in-in in-in E57 Type1 9 - 357 None None 14
Homo sapiens MK01_HUMAN 4FV7A 1.9 Active DFGin BLAminus in-in in-in E94 Type1 11 - 358 None None 0
Homo sapiens MK01_HUMAN 4FV8A 2.0 Active DFGin BLAminus in-in in-in E63 Type1 8 - 357 None None 13
Homo sapiens MK01_HUMAN 4FV9A 2.11 Active DFGin BLAminus in-in in-in E71 Type1 8 - 357 None None 14
Homo sapiens MK01_HUMAN 4G6NA 2.0 Inactive DFGin BLAminus out-out in-in EK0 Type1 11 - 358 None None 0
Homo sapiens MK01_HUMAN 4G6OA 2.2 Active DFGin BLAminus in-in in-in E28 Type1 11 - 357 None None 0
Homo sapiens MK01_HUMAN 4N0SA 1.799 Active DFGin BLAminus in-in in-in DHC Type1 6 - 357 None None 0
Homo sapiens MK01_HUMAN 4ZXTA 2.0 Active DFGin BLAminus in-in in-in CAQ Type1 7 - 357 None None 0
Homo sapiens MK01_HUMAN 5LCKA 1.89 Active DFGin BLAminus out-in in-in 6TT Type1 11 - 357 None None 0
Homo sapiens MK01_HUMAN 4QTEA 1.5 Active DFGin BLAminus in-in in-in 390 Type1 11 - 358 None None 0
Homo sapiens MK01_HUMAN 6G54A 2.05 Active DFGin BLAminus out-in in-in 6H3 Type1 10 - 356 None None 0
Homo sapiens MK01_HUMAN 5BUEA 2.4 None DFGin BLAminus in-in in-none 4V8 Type1 11 - 358 None None 15
Homo sapiens MK01_HUMAN 5BUIA 2.12 None DFGin BLAminus in-in in-none 4V9 Type1 11 - 358 None None 10
Homo sapiens MK01_HUMAN 5BUJA 1.85 None DFGin BLAminus in-in in-none 4VB Type1 9 - 358 None None 15
Homo sapiens MK01_HUMAN 5BVDA 1.9 None DFGin BLAminus in-in in-none 4VF Type1 9 - 358 None None 16
Homo sapiens MK01_HUMAN 5BVEA 2.0 None DFGin BLAminus in-in in-none 4VG Type1 9 - 358 None None 16
Homo sapiens MK01_HUMAN 5BVFA 1.9 None DFGin BLAminus in-in in-none 4VJ Type1 9 - 358 None None 17
Homo sapiens MK01_HUMAN 2Y9QA 1.55 Inactive DFGin BLAminus in-in in-out ANP Type1 9 - 358 None None 0
Homo sapiens MK01_HUMAN 4FMQA 2.098 Inactive DFGin BLAminus in-in in-out ANP Type1 9 - 358 None None 0
Homo sapiens MK01_HUMAN 4NIFB 2.15 Inactive DFGin BLAminus in-in in-out ANP Type1 9 - 360 None None 3
Homo sapiens MK01_HUMAN 4NIFE 2.15 Inactive DFGin BLAminus in-in in-out ANP Type1 10 - 360 None None 3
Homo sapiens MK01_HUMAN 7OPMA 2.45 Active DFGin BLAminus in-in in-in 08G Type1 1 - 360 None X185,X187 0
Homo sapiens MK01_HUMAN 5LCJA 1.78 Active DFGin BLAminus in-in in-in 6TS Type1 11 - 357 None None 0
Homo sapiens MK01_HUMAN 6G91A 1.8 Active DFGin BLAminus in-in in-in EQW Type1 8 - 357 None None 0
Homo sapiens MK01_HUMAN 6G92A 1.99 Active DFGin BLAminus out-in in-in ERZ Type1 8 - 357 None None 0
Homo sapiens MK01_HUMAN 6G93A 1.67 Active DFGin BLAminus in-in in-in EU2 Type1 11 - 357 None None 0
Homo sapiens MK01_HUMAN 6G97A 1.9 Active DFGin BLAminus in-in in-in EQZ Type1 11 - 357 None None 0
Homo sapiens MK01_HUMAN 6G9AA 1.91 Active DFGin BLAminus in-in in-in ESQ Type1 8 - 357 None None 0
Homo sapiens MK01_HUMAN 6G9MA 1.86 Active DFGin BLAminus in-in in-in ESW Type1 11 - 356 None None 0
Homo sapiens MK01_HUMAN 6GDQA 1.86 Active DFGin BLAminus in-in in-in EVK Type1 10 - 357 None None 0
Homo sapiens MK01_HUMAN 6GJBA 1.82 Active DFGin BLAminus in-in in-in F0H Type1 8 - 357 None None 0
Homo sapiens MK01_HUMAN 6Q7KA 1.84 Inactive DFGin BLAminus out-out in-in 2AI Type1 8 - 357 None None 0
Homo sapiens MK01_HUMAN 6QAWA 1.84 Active DFGin BLAminus out-in in-in HVE Type1 11 - 357 None None 0
Homo sapiens MK01_HUMAN 6RQ4A 1.96 Active DFGin BLAminus out-in in-in KE8 Type1 19 - 357 None None 0
Homo sapiens MK01_HUMAN 7NR3A 1.897 Active DFGin BLAminus in-in in-in UO5 Type1 11 - 356 None None 0
Homo sapiens MK01_HUMAN 8AO2A 1.796 Active DFGin BLAminus out-in in-in NXI Type1 13 - 357 None None 0
Homo sapiens MK01_HUMAN 8AO3A 1.778 Active DFGin BLAminus out-in in-in NYX Type1 11 - 357 None None 0
Homo sapiens MK01_HUMAN 8AO4A 1.825 Active DFGin BLAminus out-in in-in N8U Type1 11 - 357 None None 0
Homo sapiens MK01_HUMAN 8AO5A 1.595 Active DFGin BLAminus out-in in-in N6K Type1 15 - 356 None None 0
Homo sapiens MK01_HUMAN 8AO6A 1.811 Active DFGin BLAminus out-in in-in N9F Type1 11 - 356 None None 0
Homo sapiens MK01_HUMAN 8AO7A 1.61 Active DFGin BLAminus out-in in-in N3X Type1 11 - 356 None None 0
Homo sapiens MK01_HUMAN 8AO8A 1.697 Active DFGin BLAminus out-in in-in N5U Type1 11 - 356 None None 0
Homo sapiens MK01_HUMAN 8AO9A 1.624 Inactive DFGin BLAminus out-out in-in N4F Type1 11 - 356 None None 0
Homo sapiens MK01_HUMAN 8AOBA 1.623 Active DFGin BLAminus out-in in-in NB3 Type1 18 - 356 None None 0
Homo sapiens MK01_HUMAN 8AOCA 1.62 Active DFGin BLAminus out-in in-in N3O Type1 11 - 356 None None 0
Homo sapiens MK01_HUMAN 8AOEA 1.687 Active DFGin BLAminus out-in in-in N6U Type1 11 - 356 None None 0
Homo sapiens MK01_HUMAN 8AOFA 1.615 Active DFGin BLAminus out-in in-in N4U Type1 11 - 356 None None 0
Homo sapiens MK01_HUMAN 8AOJA 1.12 Active DFGin BLAminus in-in in-in N8L Type1 10 - 356 None None 0
Homo sapiens MK01_HUMAN 3W55A 3.0 Inactive DFGin BLAminus in-in in-out 1FM Type1 11 - 357 None None 12
Homo sapiens MK01_HUMAN 5AX3A 2.984 None DFGin BLAminus out-out in-none 5ID Type1 10 - 358 None None 9
Homo sapiens MK01_HUMAN 7W5OA 2.35 Inactive DFGin BLAminus in-out in-in 5ID Type1 11 - 360 None None 0
Homo sapiens MK01_HUMAN 7XC1B 2.09 Active DFGin BLAminus in-in in-in 5ID Type1 12 - 357 None None 0
Homo sapiens MK01_HUMAN 4O6EA 1.95 Inactive DFGin BLAminus in-in in-out 2SH Type1 13 - 357 None None 11
Homo sapiens MK01_HUMAN 4QP1A 2.7 Inactive DFGin BLAminus out-out in-in EMU Type1 12 - 360 None None 0
Homo sapiens MK01_HUMAN 4QP1B 2.7 Inactive DFGin BLAminus in-out in-in EMU Type1 12 - 357 None None 0
Homo sapiens MK01_HUMAN 4QP2A 2.23 Active DFGin BLAminus in-in in-in 36R Type1 12 - 360 None None 6
Homo sapiens MK01_HUMAN 4QP3A 2.599 Active DFGin BLAminus in-in in-in 36Q Type1 12 - 360 None None 6
Homo sapiens MK01_HUMAN 4QP3B 2.599 Active DFGin BLAminus in-in in-in 36Q Type1 12 - 357 None None 3
Homo sapiens MK01_HUMAN 4QP4A 2.2 Inactive DFGin BLAminus in-out in-out 36O Type1 13 - 357 None None 8
Homo sapiens MK01_HUMAN 4QP4B 2.2 Inactive DFGin BLAminus in-out in-out 36O Type1 12 - 357 None None 11
Homo sapiens MK01_HUMAN 4QP6A 3.1 Active DFGin BLAminus in-in in-in 36N Type1 12 - 360 None None 6
Homo sapiens MK01_HUMAN 4QP6B 3.1 Active DFGin BLAminus in-in in-in 36N Type1 12 - 357 None None 3
Homo sapiens MK01_HUMAN 4QP7A 2.249 Inactive DFGin BLAminus in-in in-out 363 Type1 13 - 357 None None 8
Homo sapiens MK01_HUMAN 4QP7B 2.249 Inactive DFGin BLAminus in-out in-out 363 Type1 12 - 357 None None 11
Homo sapiens MK01_HUMAN 4QP8A 2.446 Inactive DFGin BLAminus in-in in-out 362 Type1 12 - 357 None None 11
Homo sapiens MK01_HUMAN 4QP8B 2.446 Inactive DFGin BLAminus in-in in-out 362 Type1 13 - 357 None None 8
Homo sapiens MK01_HUMAN 4QP9A 2.001 Inactive DFGin BLAminus in-in in-out 35X Type1 13 - 357 None None 8
Homo sapiens MK01_HUMAN 4QPAA 2.85 Inactive DFGin BLAminus in-out in-in 35W Type1 12 - 357 None None 3
Homo sapiens MK01_HUMAN 4QPAB 2.85 Active DFGin BLAminus out-in in-in 35W Type1 12 - 360 None None 2
Homo sapiens MK01_HUMAN 4ZZMA 1.89 Inactive DFGin BLAminus in-out in-in CQ6 Type1 11 - 355 None None 0
Homo sapiens MK01_HUMAN 4ZZNA 1.33 Active DFGin BLAminus in-in in-in CQ8 Type1 11 - 355 None None 0
Homo sapiens MK01_HUMAN 4ZZOA 1.63 Active DFGin BLAminus in-in in-in CQ3 Type1 11 - 355 None None 0
Homo sapiens MK01_HUMAN 3TEIA 2.404 Inactive DFGin BLAminus in-in in-out ANP Type1 10 - 358 R77A,E314A None 7
Homo sapiens MK01_HUMAN 4H3PA 2.3 Inactive DFGin BLAminus in-in in-out ANP Type1 11 - 359 R77A,E314A None 7
Homo sapiens MK01_HUMAN 4H3PD 2.3 None DFGin BLAminus in-in in-none ANP Type1 11 - 359 R77A,E314A None 11
Homo sapiens MK01_HUMAN 2OJGA 2.0 Active DFGin BLAminus in-in in-in 19A Type1 19 - 357 None None 0
Homo sapiens MK01_HUMAN 2OJIA 2.6 Active DFGin BLAminus out-in in-in 33A Type1 15 - 358 None None 0
Homo sapiens MK01_HUMAN 2OJJA 2.4 Active DFGin BLAminus in-in in-in 82A Type1 15 - 358 None None 0
Homo sapiens MK01_HUMAN 3I5ZA 2.2 Active DFGin BLAminus in-in in-in Z48 Type1 8 - 357 None None 14
Homo sapiens MK01_HUMAN 3I60A 2.5 Active DFGin BLAminus in-in in-in E86 Type1 8 - 358 None None 13
Homo sapiens MK01_HUMAN 5NGUA 2.74 Active DFGin BLAminus in-in in-in 8X2 Type1 11 - 355 None None 0
Homo sapiens MK01_HUMAN 5NHFA 2.14 Inactive DFGin BLAminus in-out in-in 8X5 Type1 12 - 355 None None 0
Homo sapiens MK01_HUMAN 5NHHA 1.94 Active DFGin BLAminus in-in in-in 8XH Type1 11 - 358 None None 0
Homo sapiens MK01_HUMAN 5NHJA 2.12 Active DFGin BLAminus in-in in-in 8XE Type1 11 - 355 None None 0
Homo sapiens MK01_HUMAN 5NHLA 2.07 Active DFGin BLAminus in-in in-in 8XB Type1 11 - 355 None None 0
Homo sapiens MK01_HUMAN 5NHOA 2.24 Active DFGin BLAminus in-in in-in 8XN Type1 11 - 355 None None 0
Homo sapiens MK01_HUMAN 5NHPA 1.99 Active DFGin BLAminus in-in in-in 8XK Type1 11 - 355 None None 0
Homo sapiens MK01_HUMAN 5NHVA 2.0 Active DFGin BLAminus in-in in-in 8QB Type1 11 - 355 None None 0
Homo sapiens MK01_HUMAN 6SLGA 1.33 Active DFGin BLAminus in-in in-in LHZ Type1 18 - 356 None None 0
Homo sapiens MK01_HUMAN 5WP1A 1.4 Inactive DFGin BLAminus out-out in-in B7S BEZ Type1 Allosteric 15 - 357 None None 0
Homo sapiens MK01_HUMAN 6Q7TA 1.6 Inactive DFGin BLAminus in-out in-in HOW HOW Type1 Allosteric 11 - 356 None None 0
Homo sapiens MK01_HUMAN 6QAGA 2.07 Inactive DFGin BLAminus out-out in-in HUH HUH Type1 Allosteric 11 - 357 None None 0
Homo sapiens MK01_HUMAN 8AOAA 1.62 Active DFGin BLAminus out-in in-in N83 OZU Type1 Allosteric 11 - 356 None None 0
Homo sapiens MK01_HUMAN 8AODA 1.62 Active DFGin BLAminus in-in in-in NY0 NYI Type1 Allosteric 11 - 356 None None 0
Homo sapiens MK01_HUMAN 8AOHA 1.6 Active DFGin BLAminus out-in in-in N96 N96 Type1 Allosteric 11 - 356 None None 0
Homo sapiens MK01_HUMAN 8AOIA 1.602 Active DFGin BLAminus out-in in-in NX0 NX0 Type1 Allosteric 11 - 356 None None 0
Homo sapiens MK01_HUMAN 7XC1A 2.09 Active DFGin BLAminus in-in in-in 5ID B8Z Type1 Allosteric 10 - 360 None None 0
Homo sapiens MK01_HUMAN 7X4UA 1.98 Inactive DFGin BLAminus in-out in-in 5ID 8DK BTB Type1 Allosteric Allosteric 10 - 359 None None 0
Homo sapiens MK01_HUMAN 5V62A 1.9 Active DFGin BLAminus in-in in-in FRZ AKS Type1 Type1 10 - 360 None X185,X187 0
Homo sapiens MK01_HUMAN 6OPIA 3.0 None DFGin BLAminus in-in in-none N0V Type1.5_Front 10 - 356 None X185,X187 12
Homo sapiens MK01_HUMAN 4QTAA 1.45 None DFGin BLAminus in-in in-none 38Z Type1.5_Front 10 - 358 None None 14
Homo sapiens MK01_HUMAN 6G9DA 1.8 Active DFGin BLAminus in-in in-in ER8 Type1.5_Front 8 - 357 None None 0
Homo sapiens MK01_HUMAN 6G9HA 1.73 Active DFGin BLAminus out-in in-in ERW Type1.5_Front 11 - 357 None None 0
Homo sapiens MK01_HUMAN 6G9JA 1.98 Active DFGin BLAminus in-in in-in ERK Type1.5_Front 8 - 357 None None 0
Homo sapiens MK01_HUMAN 6G9KA 1.94 Active DFGin BLAminus in-in in-in ESK Type1.5_Front 11 - 357 None None 0
Homo sapiens MK01_HUMAN 6G9NA 1.76 Active DFGin BLAminus out-in in-in ESN Type1.5_Front 11 - 357 None None 0
Homo sapiens MK01_HUMAN 6GDMA 1.91 Active DFGin BLAminus in-in in-in F3Z Type1.5_Front 8 - 356 None None 0
Homo sapiens MK01_HUMAN 6GE0A 1.82 Active DFGin BLAminus in-in in-in EVQ Type1.5_Front 11 - 357 None None 0
Homo sapiens MK01_HUMAN 6GJDA 1.58 Active DFGin BLAminus in-in in-in F0E Type1.5_Front 10 - 357 None None 0
Homo sapiens MK01_HUMAN 7AUVA 1.76 Active DFGin BLAminus out-in in-in RYW Type1.5_Front 11 - 357 None None 0
Homo sapiens MK01_HUMAN 7NQQA 1.943 Active DFGin BLAminus in-in in-in UMN Type1.5_Front 11 - 356 None None 0
Homo sapiens MK01_HUMAN 7NQWA 1.775 Active DFGin BLAminus in-in in-in UNW Type1.5_Front 11 - 356 None None 0
Homo sapiens MK01_HUMAN 7NR5A 1.766 Active DFGin BLAminus out-in in-in UOH Type1.5_Front 11 - 357 None None 0
Homo sapiens MK01_HUMAN 7NR8A 1.627 Active DFGin BLAminus in-in in-in UOE Type1.5_Front 11 - 356 None None 0
Homo sapiens MK01_HUMAN 7NR9A 1.906 Active DFGin BLAminus out-in in-in UOW Type1.5_Front 11 - 355 None None 0
Homo sapiens MK01_HUMAN 6QAQA 1.58 Inactive DFGin BLAminus out-out in-in HVQ HVQ Type3 Allosteric 11 - 357 None None 0
Rattus norvegicus MK01_RAT 6RFPA 1.74 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 3 - 353 K229T,H230D,Y231H None 0
Rattus norvegicus MK01_RAT 4S2ZA 1.48 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 4 - 354 R65S None 0
Rattus norvegicus MK01_RAT 3R63A 1.7 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 4 - 358 S246E None 0
Rattus norvegicus MK01_RAT 6OT6A 1.65 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 9 - 356 D319N None 0
Rattus norvegicus MK01_RAT 6OTSA 2.1 Inactive DFGin BLAminus out-in in-out No_ligand No_ligand 7 - 356 E320K None 10
Rattus norvegicus MK01_RAT 3O71A 1.95 Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 9 - 354 None None 5
Rattus norvegicus MK01_RAT 4S31A 1.45 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 4 - 355 None None 0
Rattus norvegicus MK01_RAT 3ZUVA 2.72 Active DFGin BLAminus out-in in-in No_ligand No_ligand 3 - 358 None X183,X185 0
Rattus norvegicus MK01_RAT 3ZUVC 2.72 Active DFGin BLAminus out-in in-in No_ligand No_ligand 3 - 358 None X183,X185 0
Rattus norvegicus MK01_RAT 2FYSA 2.5 Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 8 - 356 None None 0
Rattus norvegicus MK01_RAT 2FYSB 2.5 Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 8 - 357 None None 8
Rattus norvegicus MK01_RAT 4GSBA 1.8 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 9 - 356 None None 0
Rattus norvegicus MK01_RAT 5UMOA 2.26 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 4 - 354 None None 0
Rattus norvegicus MK01_RAT 3ZU7A 1.97 Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 10 - 353 None None 0
Rattus norvegicus MK01_RAT 2ERKA 2.4 Active DFGin BLAminus out-in in-in No_ligand No_ligand 6 - 358 None X183,X185 0
Rattus norvegicus MK01_RAT 2GPHA 1.9 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 10 - 354 T116C None 0
Rattus norvegicus MK01_RAT 4S30A 2.0 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 4 - 355 I84A None 0
Rattus norvegicus MK01_RAT 4XNEA 1.8 Inactive DFGin BLAminus out-out in-in TT4 Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 4XRJA 1.69 Inactive DFGin BLAminus out-out in-in 620 Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 4XOYA 2.1 Inactive DFGin BLAminus out-out in-in DX4 Type1 9 - 353 None None 3
Rattus norvegicus MK01_RAT 4XP0A 1.46 Active DFGin BLAminus in-in in-in 42A Type1 8 - 354 None None 0
Rattus norvegicus MK01_RAT 4XP2A 1.748 Active DFGin BLAminus in-in in-in TT4 Type1 8 - 353 None None 0
Rattus norvegicus MK01_RAT 4XP3A 1.782 Inactive DFGin BLAminus in-out in-in DX4 Type1 8 - 354 None None 0
Rattus norvegicus MK01_RAT 6OPKA 2.54 Active DFGin BLAminus in-in in-in 390 Type1 9 - 354 None X183,X185 0
Rattus norvegicus MK01_RAT 4S33A 1.48 Active DFGin BLAminus in-in in-in ANP Type1 4 - 355 R65S None 0
Rattus norvegicus MK01_RAT 4XRLA 2.554 Active DFGin BLAminus out-in in-in 42A Type1 9 - 353 None None 0
Rattus norvegicus MK01_RAT 3C9WA 2.5 None DFGin BLAminus in-in in-none HMY Type1 6 - 354 None None 13
Rattus norvegicus MK01_RAT 3C9WB 2.5 None DFGin BLAminus in-out in-none HMY Type1 6 - 354 None None 13
Rattus norvegicus MK01_RAT 4S32A 1.34 Inactive DFGin BLAminus in-out in-in ANP Type1 4 - 354 None None 0
Rattus norvegicus MK01_RAT 3ERKA 2.1 Inactive DFGin BLAminus out-out in-in SB4 Type1 6 - 355 None None 0
Rattus norvegicus MK01_RAT 3QYWA 1.5 Inactive DFGin BLAminus in-out in-in 6PB Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 3QYZA 1.46 Active DFGin BLAminus in-in in-in Z8B Type1 8 - 354 None None 0
Rattus norvegicus MK01_RAT 4ERKA 2.2 Inactive DFGin BLAminus in-out in-in OLO Type1 6 - 355 None None 0
Rattus norvegicus MK01_RAT 4GT3A 1.68 None DFGin BLAminus in-none in-in ATP Type1 9 - 356 None None 0
Rattus norvegicus MK01_RAT 4GVAA 1.83 Inactive DFGin BLAminus out-out in-in ADP Type1 11 - 356 None None 0
Rattus norvegicus MK01_RAT 6FI3A 1.52 Active DFGin BLAminus in-in in-in DJ2 Type1 8 - 353 None None 0
Rattus norvegicus MK01_RAT 6FI6A 1.65 Active DFGin BLAminus in-in in-in DF8 Type1 8 - 354 None None 0
Rattus norvegicus MK01_RAT 6FJ0A 1.659 Active DFGin BLAminus in-in in-in A3N Type1 9 - 353 None None 0
Rattus norvegicus MK01_RAT 6FJBA 1.85 Active DFGin BLAminus in-in in-in AOC Type1 8 - 354 None None 0
Rattus norvegicus MK01_RAT 6FLEA 1.48 Inactive DFGin BLAminus in-out in-in DQ2 Type1 8 - 353 None None 0
Rattus norvegicus MK01_RAT 6FLVA 1.91 Active DFGin BLAminus in-in in-in DTW Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 6FMAA 1.667 Active DFGin BLAminus in-in in-in DU8 Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 6FN5A 1.932 Active DFGin BLAminus out-in in-in DVZ Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 6FQ7A 1.6 Inactive DFGin BLAminus in-out in-in E2K Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 6FR1A 1.561 Inactive DFGin BLAminus in-out in-in E3K Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 6FRPA 1.53 Inactive DFGin BLAminus in-out in-in ZAS Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 6FXVA 1.53 Inactive DFGin BLAminus in-out in-in E9W Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 2Z7LA 2.41 Inactive DFGin BLAminus out-out in-in S91 Type1 16 - 355 None None 0
Rattus norvegicus MK01_RAT 5KE0A 1.68 Active DFGin BLAminus in-in in-in 6S9 Type1 16 - 355 None None 0
Rattus norvegicus MK01_RAT 5U6IA 1.69 Active DFGin BLAminus in-in in-in 81Y Type1 16 - 355 None None 0
Rattus norvegicus MK01_RAT 7UGBA 1.9 Inactive DFGin BLAminus in-in in-out ANP Type1 9 - 354 None None 9
Rattus norvegicus MK01_RAT 4S34A 2.5 Inactive DFGin BLAminus in-out in-in ANP Type1 4 - 354 I84A None 0
Rattus norvegicus MK01_RAT 1GOLA 2.8 None DFGin BLAminus out-none in-in ATP Type1 2 - 358 K52R None 0
Rattus norvegicus MK01_RAT 5HD7A 1.69 Active DFGin BLAminus in-in in-in 38Z Type1 9 - 355 G167D None 0
Rattus norvegicus MK01_RAT 4N4SA 2.2 Inactive DFGin BLAminus out-out in-out 2H1 Type1.5_Back 8 - 356 Q103A,C164L None 7
Rattus norvegicus MK01_RAT 4N4SB 2.2 Inactive DFGin BLAminus out-out in-out 2H1 Type1.5_Back 8 - 356 Q103A,C164L None 12
Rattus norvegicus MK01_RAT 4XOZA 1.95 Inactive DFGin BLAminus out-out in-in 620 Type1.5_Front 8 - 354 None None 0
Rattus norvegicus MK01_RAT 4QYYA 1.65 Active DFGin BLAminus in-in in-in 3G7 Type1.5_Front 13 - 353 None None 0
Rattus norvegicus MK01_RAT 5HD4A 1.45 Active DFGin BLAminus in-in in-in 38Z Type1.5_Front 9 - 355 None None 0
Rattus norvegicus MK01_RAT 6CPWA 1.85 Active DFGin BLAminus in-in in-in F8V Type1.5_Front 16 - 355 None None 0
Rattus norvegicus MK01_RAT 6DCGA 1.45 Active DFGin BLAminus in-in in-in G67 Type1.5_Front 16 - 354 None None 0
Rattus norvegicus MK01_RAT 6RFOA 1.7 Inactive DFGin None in-out in-in No_ligand No_ligand 12 - 355 None None 6
Rattus norvegicus MK01_RAT 6FJZA 1.864 Inactive DFGin None in-in in-in DKW Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 4I5HA 1.9 Inactive DFGout None in-in out-out G17 Type2 9 - 356 Q103A,C164L None 7

MAPK1 (Mitogen-activated protein kinase 1)

Group: CMGC
Total number of chains: 64
Spatial Dihedral Chains Representative
DFGin BLAminus 61 4S32A
DFGin None 2 6FJZA
DFGout None 1 4I5HA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Rattus norvegicus MK01_RAT 6RFPA 1.74 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 3 - 353 K229T,H230D,Y231H None 0
Rattus norvegicus MK01_RAT 4S2ZA 1.48 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 4 - 354 R65S None 0
Rattus norvegicus MK01_RAT 3R63A 1.7 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 4 - 358 S246E None 0
Rattus norvegicus MK01_RAT 6OT6A 1.65 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 9 - 356 D319N None 0
Rattus norvegicus MK01_RAT 6OTSA 2.1 Inactive DFGin BLAminus out-in in-out No_ligand No_ligand 7 - 356 E320K None 10
Rattus norvegicus MK01_RAT 3O71A 1.95 Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 9 - 354 None None 5
Rattus norvegicus MK01_RAT 4S31A 1.45 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 4 - 355 None None 0
Rattus norvegicus MK01_RAT 3ZUVA 2.72 Active DFGin BLAminus out-in in-in No_ligand No_ligand 3 - 358 None X183,X185 0
Rattus norvegicus MK01_RAT 3ZUVC 2.72 Active DFGin BLAminus out-in in-in No_ligand No_ligand 3 - 358 None X183,X185 0
Rattus norvegicus MK01_RAT 2FYSA 2.5 Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 8 - 356 None None 0
Rattus norvegicus MK01_RAT 2FYSB 2.5 Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 8 - 357 None None 8
Rattus norvegicus MK01_RAT 4GSBA 1.8 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 9 - 356 None None 0
Rattus norvegicus MK01_RAT 5UMOA 2.26 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 4 - 354 None None 0
Rattus norvegicus MK01_RAT 3ZU7A 1.97 Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 10 - 353 None None 0
Rattus norvegicus MK01_RAT 2ERKA 2.4 Active DFGin BLAminus out-in in-in No_ligand No_ligand 6 - 358 None X183,X185 0
Rattus norvegicus MK01_RAT 2GPHA 1.9 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 10 - 354 T116C None 0
Rattus norvegicus MK01_RAT 4S30A 2.0 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 4 - 355 I84A None 0
Rattus norvegicus MK01_RAT 4XNEA 1.8 Inactive DFGin BLAminus out-out in-in TT4 Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 4XRJA 1.69 Inactive DFGin BLAminus out-out in-in 620 Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 4XOYA 2.1 Inactive DFGin BLAminus out-out in-in DX4 Type1 9 - 353 None None 3
Rattus norvegicus MK01_RAT 4XP0A 1.46 Active DFGin BLAminus in-in in-in 42A Type1 8 - 354 None None 0
Rattus norvegicus MK01_RAT 4XP2A 1.748 Active DFGin BLAminus in-in in-in TT4 Type1 8 - 353 None None 0
Rattus norvegicus MK01_RAT 4XP3A 1.782 Inactive DFGin BLAminus in-out in-in DX4 Type1 8 - 354 None None 0
Rattus norvegicus MK01_RAT 6OPKA 2.54 Active DFGin BLAminus in-in in-in 390 Type1 9 - 354 None X183,X185 0
Rattus norvegicus MK01_RAT 4S33A 1.48 Active DFGin BLAminus in-in in-in ANP Type1 4 - 355 R65S None 0
Rattus norvegicus MK01_RAT 4XRLA 2.554 Active DFGin BLAminus out-in in-in 42A Type1 9 - 353 None None 0
Rattus norvegicus MK01_RAT 3C9WA 2.5 None DFGin BLAminus in-in in-none HMY Type1 6 - 354 None None 13
Rattus norvegicus MK01_RAT 3C9WB 2.5 None DFGin BLAminus in-out in-none HMY Type1 6 - 354 None None 13
Rattus norvegicus MK01_RAT 4S32A 1.34 Inactive DFGin BLAminus in-out in-in ANP Type1 4 - 354 None None 0
Rattus norvegicus MK01_RAT 3ERKA 2.1 Inactive DFGin BLAminus out-out in-in SB4 Type1 6 - 355 None None 0
Rattus norvegicus MK01_RAT 3QYWA 1.5 Inactive DFGin BLAminus in-out in-in 6PB Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 3QYZA 1.46 Active DFGin BLAminus in-in in-in Z8B Type1 8 - 354 None None 0
Rattus norvegicus MK01_RAT 4ERKA 2.2 Inactive DFGin BLAminus in-out in-in OLO Type1 6 - 355 None None 0
Rattus norvegicus MK01_RAT 4GT3A 1.68 None DFGin BLAminus in-none in-in ATP Type1 9 - 356 None None 0
Rattus norvegicus MK01_RAT 4GVAA 1.83 Inactive DFGin BLAminus out-out in-in ADP Type1 11 - 356 None None 0
Rattus norvegicus MK01_RAT 6FI3A 1.52 Active DFGin BLAminus in-in in-in DJ2 Type1 8 - 353 None None 0
Rattus norvegicus MK01_RAT 6FI6A 1.65 Active DFGin BLAminus in-in in-in DF8 Type1 8 - 354 None None 0
Rattus norvegicus MK01_RAT 6FJ0A 1.659 Active DFGin BLAminus in-in in-in A3N Type1 9 - 353 None None 0
Rattus norvegicus MK01_RAT 6FJBA 1.85 Active DFGin BLAminus in-in in-in AOC Type1 8 - 354 None None 0
Rattus norvegicus MK01_RAT 6FLEA 1.48 Inactive DFGin BLAminus in-out in-in DQ2 Type1 8 - 353 None None 0
Rattus norvegicus MK01_RAT 6FLVA 1.91 Active DFGin BLAminus in-in in-in DTW Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 6FMAA 1.667 Active DFGin BLAminus in-in in-in DU8 Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 6FN5A 1.932 Active DFGin BLAminus out-in in-in DVZ Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 6FQ7A 1.6 Inactive DFGin BLAminus in-out in-in E2K Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 6FR1A 1.561 Inactive DFGin BLAminus in-out in-in E3K Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 6FRPA 1.53 Inactive DFGin BLAminus in-out in-in ZAS Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 6FXVA 1.53 Inactive DFGin BLAminus in-out in-in E9W Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 2Z7LA 2.41 Inactive DFGin BLAminus out-out in-in S91 Type1 16 - 355 None None 0
Rattus norvegicus MK01_RAT 5KE0A 1.68 Active DFGin BLAminus in-in in-in 6S9 Type1 16 - 355 None None 0
Rattus norvegicus MK01_RAT 5U6IA 1.69 Active DFGin BLAminus in-in in-in 81Y Type1 16 - 355 None None 0
Rattus norvegicus MK01_RAT 7UGBA 1.9 Inactive DFGin BLAminus in-in in-out ANP Type1 9 - 354 None None 9
Rattus norvegicus MK01_RAT 4S34A 2.5 Inactive DFGin BLAminus in-out in-in ANP Type1 4 - 354 I84A None 0
Rattus norvegicus MK01_RAT 1GOLA 2.8 None DFGin BLAminus out-none in-in ATP Type1 2 - 358 K52R None 0
Rattus norvegicus MK01_RAT 5HD7A 1.69 Active DFGin BLAminus in-in in-in 38Z Type1 9 - 355 G167D None 0
Rattus norvegicus MK01_RAT 4N4SA 2.2 Inactive DFGin BLAminus out-out in-out 2H1 Type1.5_Back 8 - 356 Q103A,C164L None 7
Rattus norvegicus MK01_RAT 4N4SB 2.2 Inactive DFGin BLAminus out-out in-out 2H1 Type1.5_Back 8 - 356 Q103A,C164L None 12
Rattus norvegicus MK01_RAT 4XOZA 1.95 Inactive DFGin BLAminus out-out in-in 620 Type1.5_Front 8 - 354 None None 0
Rattus norvegicus MK01_RAT 4QYYA 1.65 Active DFGin BLAminus in-in in-in 3G7 Type1.5_Front 13 - 353 None None 0
Rattus norvegicus MK01_RAT 5HD4A 1.45 Active DFGin BLAminus in-in in-in 38Z Type1.5_Front 9 - 355 None None 0
Rattus norvegicus MK01_RAT 6CPWA 1.85 Active DFGin BLAminus in-in in-in F8V Type1.5_Front 16 - 355 None None 0
Rattus norvegicus MK01_RAT 6DCGA 1.45 Active DFGin BLAminus in-in in-in G67 Type1.5_Front 16 - 354 None None 0
Rattus norvegicus MK01_RAT 6RFOA 1.7 Inactive DFGin None in-out in-in No_ligand No_ligand 12 - 355 None None 6
Rattus norvegicus MK01_RAT 6FJZA 1.864 Inactive DFGin None in-in in-in DKW Type1 9 - 354 None None 0
Rattus norvegicus MK01_RAT 4I5HA 1.9 Inactive DFGout None in-in out-out G17 Type2 9 - 356 Q103A,C164L None 7