INSR (Insulin receptor)

Group: TYR
Uniprot: INSR_HUMAN
Domain boundary: 1023 - 1292


Total number of chains: 25
Spatial Dihedral Chains Representative
DFGin BLAminus 9 AF-P06213-K1A
DFGin ABAminus 4 3BU6A
DFGin None 8 5HHWA
DFGout BBAminus 3 1IRKA
None None 1 8DWNA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
2AUHA 3.2 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 1011 - 1310 C1008S X1185,X1189,X1190 0
2B4SB 2.3 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 1014 - 1310 C1008S X1185,X1189,X1190 0
2B4SD 2.3 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 1014 - 1310 C1008S X1185,X1189,X1190 0
3BU6A 1.95 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 1014 - 1310 C1008S X1185,X1189,X1190 0
AF-P06213-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1015 - 1300 None None 0
1GAGA 2.7 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1008 - 1310 C1008S,Y1011F X1185,X1189,X1190 0
1RQQA 2.6 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1014 - 1310 C1008S X1185,X1189,X1190 0
1RQQB 2.6 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1014 - 1310 C1008S X1185,X1189,X1190 0
3BU3A 1.65 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 1014 - 1310 C1008S X1185,X1189,X1190 0
2Z8CA 3.25 Inactive DFGin BLAminus in-out in-in S91 Type1 1011 - 1310 C1008S,Y1011F X1185,X1189,X1190 0
1IR3A 1.9 Inactive DFGin BLAminus in-out in-in ANP Type1 1008 - 1310 C1008S,Y1011F X1185,X1189,X1190 0
3BU5A 2.1 Active DFGin BLAminus in-in in-in ATP Type1 1014 - 1310 C1008S X1185,X1189,X1190 0
4XLVA 2.3 Active DFGin BLAminus in-in in-in ACP Type1 1001 - 1310 Y992F,C1008S X999,X1185,X1189,X1190 0
1P14A 1.9 Inactive DFGin None in-out none-none No_ligand No_ligand 1005 - 1310 C1008S,D1159N None 19
4IBMA 1.8 Inactive DFGin None out-out out-in IR1 Type1 1009 - 1309 K1278N None 0
4IBMB 1.8 Inactive DFGin None in-out out-in IR1 Type1 1014 - 1310 K1278N None 0
1I44A 2.4 Inactive DFGin None in-out none-in ACP Type1 1013 - 1310 C1008S,Y1011F,D1188A None 16
5E1SA 2.264 Inactive DFGin None in-out none-out 5JA Type1 1010 - 1310 None None 17
3EKKA 2.1 Inactive DFGin None in-out none-in GS2 Type1 1007 - 1309 C1008S,D1159N None 18
3EKNA 2.2 Inactive DFGin None in-out out-in GS3 Type1 1011 - 1310 C1008S,D1159N None 3
5HHWA 1.79 Inactive DFGin None in-out out-in 60O Type1.5_Front 1005 - 1310 C1008S,D1159N None 0
1IRKA 2.1 Inactive DFGout BBAminus in-out out-in No_ligand No_ligand 1008 - 1310 None None 0
3ETAA 2.6 Inactive DFGout BBAminus in-in out-in 351 Type2 1017 - 1310 None None 1
3ETAB 2.6 Inactive DFGout BBAminus in-in out-in 351 Type2 1017 - 1310 None None 2
8DWNA 2.15 Inactive None None in-out none-in No_ligand No_ligand 1014 - 1310 C1008S,Y1011F X1185,X1189 11

INSR (Insulin receptor)

Group: TYR
Total number of chains: 25
Spatial Dihedral Chains Representative
DFGin BLAminus 9 AF-P06213-K1A
DFGin ABAminus 4 3BU6A
DFGin None 8 5HHWA
DFGout BBAminus 3 1IRKA
None None 1 8DWNA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens INSR_HUMAN 2AUHA 3.2 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 1011 - 1310 C1008S X1185,X1189,X1190 0
Homo sapiens INSR_HUMAN 2B4SB 2.3 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 1014 - 1310 C1008S X1185,X1189,X1190 0
Homo sapiens INSR_HUMAN 2B4SD 2.3 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 1014 - 1310 C1008S X1185,X1189,X1190 0
Homo sapiens INSR_HUMAN 3BU6A 1.95 Inactive DFGin ABAminus in-in in-in No_ligand No_ligand 1014 - 1310 C1008S X1185,X1189,X1190 0
Homo sapiens INSR_HUMAN AF-P06213-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1015 - 1300 None None 0
Homo sapiens INSR_HUMAN 1GAGA 2.7 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1008 - 1310 C1008S,Y1011F X1185,X1189,X1190 0
Homo sapiens INSR_HUMAN 1RQQA 2.6 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1014 - 1310 C1008S X1185,X1189,X1190 0
Homo sapiens INSR_HUMAN 1RQQB 2.6 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1014 - 1310 C1008S X1185,X1189,X1190 0
Homo sapiens INSR_HUMAN 3BU3A 1.65 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 1014 - 1310 C1008S X1185,X1189,X1190 0
Homo sapiens INSR_HUMAN 2Z8CA 3.25 Inactive DFGin BLAminus in-out in-in S91 Type1 1011 - 1310 C1008S,Y1011F X1185,X1189,X1190 0
Homo sapiens INSR_HUMAN 1IR3A 1.9 Inactive DFGin BLAminus in-out in-in ANP Type1 1008 - 1310 C1008S,Y1011F X1185,X1189,X1190 0
Homo sapiens INSR_HUMAN 3BU5A 2.1 Active DFGin BLAminus in-in in-in ATP Type1 1014 - 1310 C1008S X1185,X1189,X1190 0
Homo sapiens INSR_HUMAN 4XLVA 2.3 Active DFGin BLAminus in-in in-in ACP Type1 1001 - 1310 Y992F,C1008S X999,X1185,X1189,X1190 0
Homo sapiens INSR_HUMAN 1P14A 1.9 Inactive DFGin None in-out none-none No_ligand No_ligand 1005 - 1310 C1008S,D1159N None 19
Homo sapiens INSR_HUMAN 4IBMA 1.8 Inactive DFGin None out-out out-in IR1 Type1 1009 - 1309 K1278N None 0
Homo sapiens INSR_HUMAN 4IBMB 1.8 Inactive DFGin None in-out out-in IR1 Type1 1014 - 1310 K1278N None 0
Homo sapiens INSR_HUMAN 1I44A 2.4 Inactive DFGin None in-out none-in ACP Type1 1013 - 1310 C1008S,Y1011F,D1188A None 16
Homo sapiens INSR_HUMAN 5E1SA 2.264 Inactive DFGin None in-out none-out 5JA Type1 1010 - 1310 None None 17
Homo sapiens INSR_HUMAN 3EKKA 2.1 Inactive DFGin None in-out none-in GS2 Type1 1007 - 1309 C1008S,D1159N None 18
Homo sapiens INSR_HUMAN 3EKNA 2.2 Inactive DFGin None in-out out-in GS3 Type1 1011 - 1310 C1008S,D1159N None 3
Homo sapiens INSR_HUMAN 5HHWA 1.79 Inactive DFGin None in-out out-in 60O Type1.5_Front 1005 - 1310 C1008S,D1159N None 0
Homo sapiens INSR_HUMAN 1IRKA 2.1 Inactive DFGout BBAminus in-out out-in No_ligand No_ligand 1008 - 1310 None None 0
Homo sapiens INSR_HUMAN 3ETAA 2.6 Inactive DFGout BBAminus in-in out-in 351 Type2 1017 - 1310 None None 1
Homo sapiens INSR_HUMAN 3ETAB 2.6 Inactive DFGout BBAminus in-in out-in 351 Type2 1017 - 1310 None None 2
Homo sapiens INSR_HUMAN 8DWNA 2.15 Inactive None None in-out none-in No_ligand No_ligand 1014 - 1310 C1008S,Y1011F X1185,X1189 11

INSR (Insulin receptor)

No non-human structures known.