STE_MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)

Total number of chains: 115
Active chains: 2
Uniprot: MP2K1_HUMAN
Kinase Domain Residues: 68 - 361
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 100 87.0% 9AXXA
None None 5 4.3% 7F2XA
DFGin None 3 2.6% 5YT3B
DFGin BLAminus 2 1.7% AF-Q02750-K1A
DFGin BLBminus 2 1.7% 8CHFE
DFGout None 2 1.7% 5HZEA
DFGinter None 1 0.9% 5YT3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q02750-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 60 - 369 0 None None Dual specificity mitogen-activated protein kinase kinase 1
AF-Q02750-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 60 - 369 0 None None Dual specificity mitogen-activated protein kinase kinase 1
8CHFE 4.25 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo No_ligand No_ligand 62 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
8CHFF 4.25 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo No_ligand No_ligand 62 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
3EQDA 2.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo AGS ATPlike 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
3EQIA 1.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ADP ATPlike 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
5YT3C 2.9 Inactive DFGin‑BLBplus out-none none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 40 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
6U2GA 2.886 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP ATPlike 43 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1
6V2WB 3.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP ATPlike 40 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
4MNEA 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type1 63 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1
4MNED 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type1 66 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
8DGSB 4.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo AGS, LCJ ATPlike, Type1 38 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
4AN3A 2.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_onno ATP, 5Y0 ATPlike, Type3 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1
4AN9A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_onoo ACP, 2P7 ATPlike, Type3 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1
3SLSA 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nooo ANP, 77D ATPlike, Type3 45 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1
3SLSB 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nooo ANP, 77D ATPlike, Type3 45 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1
7B3MA 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno ANP, SU5 ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
7B3MB 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnno ANP, SU5 ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
7B7RA 1.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno ANP, T1K ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
7B7RB 1.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn ANP, T1K ATPlike, Type3 39 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
7B94A 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnno ANP, T3W ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
7B94B 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn ANP, T3W ATPlike, Type3 41 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
7B9LA 1.7 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn ANP, T4N ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
7B9LB 1.7 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn ANP, T4N ATPlike, Type3 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1
3ORNA 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3OR ATPlike, Type3 62 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1
3OS3A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP, 3OS ATPlike, Type3 62 - 378 0 None None Dual specificity mitogen-activated protein kinase kinase 1
3WIGA 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, CHU ATPlike, Type3 62 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1
3DV3A 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno ATP, MEK ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
3MBLA 2.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP, LSG ATPlike, Type3 62 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1
3PP1A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP, IZG ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
3EQBA 2.62 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo ATP, LUG ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
4U80A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnoo ANP, 3EX ATPlike, Type3 62 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1
1S9JA 2.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo ATP, BBM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
3DY7A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnno ATP, 1CX ATPlike, Type3 62 - 364 0 None None Dual specificity mitogen-activated protein kinase kinase 1
3E8NA 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_onoo ATP, VRA ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
3VVHA 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanio APEdist_nnnn ATP, 4BM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
3VVHB 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ATP, 4BM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
3VVHC 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP, 4BM ATPlike, Type3 62 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1
4ARKA 2.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP, M3K ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
4LMNA 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, EUI ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
4MNEE 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type3 62 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1
3EQGA 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ADP, 4BM ATPlike, Type3 39 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
7UMBC 3.231 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, U9F ATPlike, Type3 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1
6PP9B 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, LCJ ATPlike, Type3 38 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
7M0VB 3.16 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, EUI ATPlike, Type3 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
7M0WB 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOA ATPlike, Type3 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
7M0XB 2.47 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 40 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
7M0YB 3.45 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type3 43 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
7M0ZB 3.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, CHU ATPlike, Type3 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
8DGTB 3.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo AGS, LCJ ATPlike, Type3 43 - 385 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
6NYBB 4.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP, LCJ ATPlike, Type3 56 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
9MMPB 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 62 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
9MMQB 2.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 62 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
9MMRB 3.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 62 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
9MMSB 3.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 63 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
4MNEH 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ACP, 573, 573 ATPlike, Type3, Allosteric 66 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1
9AXMC 2.42 Inactive DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE Type1 43 - 376 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
7PQVA 2.13 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo 80C Type1 39 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
3ZLSA 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 92P Type1 39 - 382 0 None S298N,S299K,Y300K Dual specificity mitogen-activated protein kinase kinase 1
3ZLXA 2.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo 5EZ Type1 39 - 382 0 None S298N,S299K,Y300K Dual specificity mitogen-activated protein kinase kinase 1
3ZM4A 2.37 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno 22T Type1 40 - 382 0 None S298N,S299K,Y300K Dual specificity mitogen-activated protein kinase kinase 1
5BX0A 2.93 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 4W5 Type1 39 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
7XNCA 2.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo GIK Type1 37 - 382 0 None S298N,S299K,Y300K Dual specificity mitogen-activated protein kinase kinase 1
3ZLYA 2.11 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo YSO Type1 40 - 382 0 None S298N,S299N,Y300K Dual specificity mitogen-activated protein kinase kinase 1
5EYMA 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 5U5 Type1 41 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
5EYMB 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 5U5 Type1 41 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
3EQFA 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo KSA Type1 39 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
9O0UB 2.91 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU Type1 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
3ZLWA 2.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo MT8 Type1 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
9AXHA 2.81 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 39 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1
9AXHB 2.81 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 38 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1
9AXMA 2.42 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 38 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
9AXXA 2.07 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 41 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
9AXXC 2.07 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 37 - 378 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
9AYAB 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 42 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
9AYAD 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno A1AHE, ANP Type1, ATPlike 39 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
9AY7B 2.41 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 33 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
9O0UH 2.91 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
9O0VB 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
9O0VH 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
7XLPA 2.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno FZC Type1.5_Back 37 - 382 0 None S298N,S299K,Y300K Dual specificity mitogen-activated protein kinase kinase 1
7MFDB 3.66 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU Type3 52 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1
9O2ZB 3.83 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU Type3 52 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1
9AXAB 4.36 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE Type3 52 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
9AXAD 4.36 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE Type3 59 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
9AXCB 4.16 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE Type3 52 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
9AXCD 4.16 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo A1AHE Type3 59 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
9O0UD 2.91 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU Type3 31 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
9O0UF 2.91 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU Type3 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
4AN2A 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo EUI, ACP Type3, ATPlike 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1
4ANBA 2.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YQY, ACP Type3, ATPlike 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1
2P55A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo MRA, ATP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
4U7ZA 2.805 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_onoo 3EW, ANP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
4U81A 2.701 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo 3EY, ANP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
3V01A 2.705 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo 3V0, ATP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
3V04A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo V04, ATP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
3EQCA 1.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo 3BM, AGS Type3, ATPlike 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
3EQHA 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 5BM, ADP Type3, ATPlike 39 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
9ECUB 3.46 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo A1BIS, ANP Type3, ATPlike 43 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1
9AXYB 3.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type3, ATPlike 40 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
9O0VD 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type3, ATPlike 31 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
9O0VF 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type3, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
7M0TB 3.19 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo 3EW, ANP Type3, ATPlike 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
7M0UB 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo QO7, ANP Type3, ATPlike 43 - 385 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
5YT3B 2.9 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ANP ATPlike 40 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
5YT3D 2.9 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP ATPlike 39 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
8YP4A 2.35 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoio APEdist_nnoo WNT Type1 34 - 384 0 None T286A,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
5YT3A 2.9 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn ANP ATPlike 39 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
5HZEA 2.4 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oooo E62 Type1 43 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
8YP4B 2.35 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn WNT Type1 43 - 383 0 None T286A,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
7F2XA 2.007 Inactive None‑None out-out out-out nonTYR APEdihe_aaiio APEdist_oooo ANP ATPlike 45 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
3W8QA 2.2 Inactive None‑None out-out out-out nonTYR APEdihe_aaioo APEdist_oooo AGS ATPlike 39 - 382 0 None T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
6Q0TC 5.7 Inactive None‑None out-none out-out nonTYR APEdihe_aaono APEdist_oooo LCJ, AGS Type1, ATPlike 43 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
6Q0JC 4.9 Inactive None‑None out-none out-out nonTYR APEdihe_aaono APEdist_oooo LCJ, AGS Type1, ATPlike 43 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
6Q0JD 4.9 Inactive None‑None out-none out-out nonTYR APEdihe_aaono APEdist_oooo LCJ, AGS Type1, ATPlike 43 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1

STE_MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)

Total number of chains: 129
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 114 88.4% 9AXXA
None None 5 3.9% 7F2XA
DFGin None 3 2.3% 5YT3B
DFGin BLAminus 2 1.6% AF-Q02750-K1A
DFGin BLBminus 2 1.6% 8CHFE
DFGout None 2 1.6% 5HZEA
DFGinter None 1 0.8% 5YT3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
MP2K1_HUMAN AF-Q02750-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 60 - 369 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN AF-Q02750-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 60 - 369 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 8CHFE 4.25 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo No_ligand No_ligand 62 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 8CHFF 4.25 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo No_ligand No_ligand 62 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3EQDA 2.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo AGS ATPlike 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3EQIA 1.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ADP ATPlike 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 5YT3C 2.9 Inactive DFGin‑BLBplus out-none none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 40 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 6U2GA 2.886 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP ATPlike 43 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 6V2WB 3.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP ATPlike 40 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 4MNEA 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type1 63 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 4MNED 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type1 66 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 8DGSB 4.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo AGS, LCJ ATPlike, Type1 38 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 4AN3A 2.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_onno ATP, 5Y0 ATPlike, Type3 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 4AN9A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_onoo ACP, 2P7 ATPlike, Type3 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3SLSA 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nooo ANP, 77D ATPlike, Type3 45 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3SLSB 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nooo ANP, 77D ATPlike, Type3 45 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7B3MA 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno ANP, SU5 ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7B3MB 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnno ANP, SU5 ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7B7RA 1.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno ANP, T1K ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7B7RB 1.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn ANP, T1K ATPlike, Type3 39 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7B94A 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnno ANP, T3W ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7B94B 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn ANP, T3W ATPlike, Type3 41 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7B9LA 1.7 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn ANP, T4N ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7B9LB 1.7 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn ANP, T4N ATPlike, Type3 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3ORNA 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3OR ATPlike, Type3 62 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3OS3A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP, 3OS ATPlike, Type3 62 - 378 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3WIGA 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, CHU ATPlike, Type3 62 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3DV3A 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno ATP, MEK ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3MBLA 2.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP, LSG ATPlike, Type3 62 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3PP1A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP, IZG ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3EQBA 2.62 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo ATP, LUG ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 4U80A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnoo ANP, 3EX ATPlike, Type3 62 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 1S9JA 2.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo ATP, BBM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3DY7A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnno ATP, 1CX ATPlike, Type3 62 - 364 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3E8NA 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_onoo ATP, VRA ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3VVHA 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanio APEdist_nnnn ATP, 4BM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3VVHB 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ATP, 4BM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3VVHC 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP, 4BM ATPlike, Type3 62 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 4ARKA 2.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP, M3K ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 4LMNA 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, EUI ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 4MNEE 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type3 62 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3EQGA 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ADP, 4BM ATPlike, Type3 39 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7UMBC 3.231 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, U9F ATPlike, Type3 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 6PP9B 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, LCJ ATPlike, Type3 38 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7M0VB 3.16 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, EUI ATPlike, Type3 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7M0WB 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOA ATPlike, Type3 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7M0XB 2.47 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 40 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7M0YB 3.45 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type3 43 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7M0ZB 3.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, CHU ATPlike, Type3 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 8DGTB 3.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo AGS, LCJ ATPlike, Type3 43 - 385 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 6NYBB 4.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP, LCJ ATPlike, Type3 56 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9MMPB 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 62 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9MMQB 2.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 62 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9MMRB 3.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 62 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9MMSB 3.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 63 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 4MNEH 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ACP, 573, 573 ATPlike, Type3, Allosteric 66 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9AXMC 2.42 Inactive DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE Type1 43 - 376 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7PQVA 2.13 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo 80C Type1 39 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3ZLSA 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 92P Type1 39 - 382 0 None S298N,S299K,Y300K Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3ZLXA 2.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo 5EZ Type1 39 - 382 0 None S298N,S299K,Y300K Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3ZM4A 2.37 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno 22T Type1 40 - 382 0 None S298N,S299K,Y300K Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 5BX0A 2.93 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 4W5 Type1 39 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7XNCA 2.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo GIK Type1 37 - 382 0 None S298N,S299K,Y300K Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3ZLYA 2.11 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo YSO Type1 40 - 382 0 None S298N,S299N,Y300K Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 5EYMA 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 5U5 Type1 41 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 5EYMB 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 5U5 Type1 41 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3EQFA 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo KSA Type1 39 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9O0UB 2.91 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU Type1 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3ZLWA 2.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo MT8 Type1 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9AXHA 2.81 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 39 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9AXHB 2.81 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 38 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9AXMA 2.42 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 38 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9AXXA 2.07 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 41 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9AXXC 2.07 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 37 - 378 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9AYAB 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 42 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9AYAD 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno A1AHE, ANP Type1, ATPlike 39 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9AY7B 2.41 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 33 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9O0UH 2.91 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9O0VB 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9O0VH 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7XLPA 2.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno FZC Type1.5_Back 37 - 382 0 None S298N,S299K,Y300K Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7MFDB 3.66 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU Type3 52 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9O2ZB 3.83 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU Type3 52 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9AXAB 4.36 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE Type3 52 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9AXAD 4.36 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE Type3 59 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9AXCB 4.16 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE Type3 52 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9AXCD 4.16 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo A1AHE Type3 59 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9O0UD 2.91 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU Type3 31 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9O0UF 2.91 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU Type3 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 4AN2A 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo EUI, ACP Type3, ATPlike 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 4ANBA 2.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo YQY, ACP Type3, ATPlike 61 - 381 0 None S218E,S222E,G328A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 2P55A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo MRA, ATP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 4U7ZA 2.805 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_onoo 3EW, ANP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 4U81A 2.701 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo 3EY, ANP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3V01A 2.705 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo 3V0, ATP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3V04A 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo V04, ATP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3EQCA 1.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo 3BM, AGS Type3, ATPlike 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3EQHA 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo 5BM, ADP Type3, ATPlike 39 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9ECUB 3.46 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo A1BIS, ANP Type3, ATPlike 43 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9AXYB 3.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type3, ATPlike 40 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9O0VD 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type3, ATPlike 31 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 9O0VF 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type3, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7M0TB 3.19 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo 3EW, ANP Type3, ATPlike 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7M0UB 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo QO7, ANP Type3, ATPlike 43 - 385 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 5YT3B 2.9 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ANP ATPlike 40 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 5YT3D 2.9 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP ATPlike 39 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 8YP4A 2.35 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoio APEdist_nnoo WNT Type1 34 - 384 0 None T286A,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 5YT3A 2.9 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn ANP ATPlike 39 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 5HZEA 2.4 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oooo E62 Type1 43 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 8YP4B 2.35 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn WNT Type1 43 - 383 0 None T286A,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 7F2XA 2.007 Inactive None‑None out-out out-out nonTYR APEdihe_aaiio APEdist_oooo ANP ATPlike 45 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 3W8QA 2.2 Inactive None‑None out-out out-out nonTYR APEdihe_aaioo APEdist_oooo AGS ATPlike 39 - 382 0 None T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 6Q0TC 5.7 Inactive None‑None out-none out-out nonTYR APEdihe_aaono APEdist_oooo LCJ, AGS Type1, ATPlike 43 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 6Q0JC 4.9 Inactive None‑None out-none out-out nonTYR APEdihe_aaono APEdist_oooo LCJ, AGS Type1, ATPlike 43 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_HUMAN 6Q0JD 4.9 Inactive None‑None out-none out-out nonTYR APEdihe_aaono APEdist_oooo LCJ, AGS Type1, ATPlike 43 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
MP2K1_RABIT 7JUQC 3.22 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP ATPlike 40 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JUWC 2.88 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP ATPlike 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 2Y4IC 3.46 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP ATPlike 37 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JURC 2.82 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type1 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JUTC 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3EW ATPlike, Type3 41 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JUUC 3.19 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 43 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JUVC 3.36 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, VKG ATPlike, Type3 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JUXC 3.34 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type3 40 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JUYC 3.096 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, EUI ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JUZC 3.21 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3EW ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JV0C 3.63 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JV1C 3.62 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, VKG ATPlike, Type3 40 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 5KKRC 3.509 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo No_ligand No_ligand 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JUSC 2.99 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo VKD, ANP Type3, ATPlike 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus

STE_MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)

Total number of chains: 14
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 14 100.0% 7JUWC
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
MP2K1_RABIT 7JUQC 3.22 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ADP ATPlike 40 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JUWC 2.88 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP ATPlike 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 2Y4IC 3.46 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP ATPlike 37 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JURC 2.82 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type1 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JUTC 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3EW ATPlike, Type3 41 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JUUC 3.19 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 43 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JUVC 3.36 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, VKG ATPlike, Type3 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JUXC 3.34 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type3 40 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JUYC 3.096 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, EUI ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JUZC 3.21 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3EW ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JV0C 3.63 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JV1C 3.62 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, VKG ATPlike, Type3 40 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 5KKRC 3.509 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo No_ligand No_ligand 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
MP2K1_RABIT 7JUSC 2.99 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo VKD, ANP Type3, ATPlike 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus