STE_MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)

Total number of chains: 115
Active chains: 2
Uniprot: MP2K1_HUMAN
Kinase Domain Residues: 68 - 361
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 100 87.0% 9AXXA
None None 5 4.3% 7F2XA
DFGin None 3 2.6% 5YT3B
DFGin BLAminus 2 1.7% AF-Q02750-K1A
DFGin BLBminus 2 1.7% 8CHFE
DFGout None 2 1.7% 5HZEA
DFGinter None 1 0.9% 5YT3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP2K1 AF-Q02750-K1A Q02750 60 369 393.0 No_ligand No_ligand Active DFGin 6.7617 13.9206 BLAminus -141.48, 178.33 62.51, 67.83 -84.66, 11.29 303.49, 105.97 -58.9, -35.51 in-in in 8.7469 Saltbr-in 2.7808 HRD-in -71.48, -46.02 68.89, 6.27 in-in-in SNCiii in-in ActLoopNT-in 3.1613 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.25, 157.79 APE9-dihe-na 87.59, -179.27 APE8-dihe-in -77.79, 114.77 APE8-rot-in 310.06 APE67-dihe-in -64.37, -36.32 -49.36, -36.23 APE12-dist-in 9.1608 APE11-dist-in 11.0784 APE10-dist-in 5.1468 APE9-dist-in 3.6476 None None None AF2 -1.0 1.0 1.0 A 310.0 310.0 0 26 26 0 [[68, 361]] 1.0 AF-Q02750-K1 STE_MAP2K1_HUMAN STE 1e-97 332.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 AF-Q02750-K3A Q02750 60 369 393.0 No_ligand No_ligand Active DFGin 6.5567 14.3808 BLAminus -143.24, 178.57 58.61, 67.22 -80.37, 9.59 297.91, 96.18 -56.08, -30.18 in-in in 8.7799 Saltbr-in 2.7216 HRD-in -72.62, -42.76 70.59, -5.92 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.2, 127.08 APE9-dihe-na 138.9, -176.14 APE8-dihe-in -75.17, 114.71 APE8-rot-in 307.94 APE67-dihe-in -66.43, -20.65 -55.45, -37.06 APE12-dist-in 8.962 APE11-dist-in 11.3261 APE10-dist-in 5.4896 APE9-dist-in 3.9396 None None None AF2 -1.0 1.0 1.0 A 310.0 310.0 0 26 26 0 [[68, 361]] 1.0 AF-Q02750-K3 STE_MAP2K1_HUMAN STE 1e-97 332.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 8CHFE Q02750 62 379 393.0 No_ligand No_ligand Inactive DFGin 8.7484 15.2997 BLBminus -137.77, -175.22 48.59, 66.74 -80.75, 172.08 303.75, 164.33 -88.09, 43.03 out-out out 15.1413 Saltbr-out 14.1559 HRD-in -63.69, -43.07 70.86, -8.01 out-out-out SNCooo out-out ActLoopNT-out 9.061 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -100.97, 134.92 APE9-dihe-na -78.84, 122.16 APE8-dihe-out -62.21, -40.86 APE8-rot-out 69.52 APE67-dihe-out -84.12, 93.44 -141.68, 94.92 APE12-dist-out 16.2177 APE11-dist-out 19.9204 APE10-dist-out 22.4925 APE9-dist-out 12.4155 S218A,S222A None None EM 4.25 0.445 999.0 E 393.0 278.0 40 26 26 0 [[68, 361]] 1.0 8chf STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 8CHFF Q02750 62 379 393.0 No_ligand No_ligand Inactive DFGin 8.7485 15.2989 BLBminus -137.78, -175.27 48.68, 66.76 -80.77, 172.08 303.82, 164.27 -88.11, 43.03 out-out out 15.1413 Saltbr-out 14.1562 HRD-in -63.7, -43.05 70.8, -7.98 out-out-out SNCooo out-out ActLoopNT-out 9.0612 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -100.94, 134.91 APE9-dihe-na -78.8, 122.14 APE8-dihe-out -62.21, -40.91 APE8-rot-out 69.52 APE67-dihe-out -84.11, 93.44 -141.62, 94.91 APE12-dist-out 16.2176 APE11-dist-out 19.9205 APE10-dist-out 22.4925 APE9-dist-out 12.4151 S218A,S222A None None EM 4.25 0.445 999.0 F 393.0 278.0 40 26 26 0 [[68, 361]] 1.0 8chf STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3EQDA Q02750 39 382 393.0 AGS:2 ATPlike Inactive DFGin 5.9616 14.1078 BLBplus -148.22, 169.15 61.13, 42.77 -94.74, 116.91 42.1, 90.93 -43.97, 123.65 out-out out 15.0819 Saltbr-out 14.8735 HRD-in -61.74, -59.42 83.27, -18.79 out-out-out SNCooo out-out ActLoopNT-out 10.9097 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -139.36, 111.64 APE9-dihe-na -74.03, 166.79 APE8-dihe-in -61.05, 144.18 APE8-rot-out 194.8 APE67-dihe-in -63.95, -10.98 -107.09, 3.75 APE12-dist-out 19.9512 APE11-dist-out 15.017 APE10-dist-out 16.7322 APE9-dist-out 9.444 S298N,S299K,Y300F None None XRAY 2.1 0.211 999.0 A 360.0 315.0 29 26 26 0 [[68, 361]] 1.0 3eqd STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3EQIA Q02750 39 382 393.0 ADP:2 ATPlike Inactive DFGin 6.097 14.1456 BLBplus -145.58, 171.19 59.48, 41.15 -92.75, 128.75 41.67, 88.89 -58.7, 127.06 out-out out 15.2136 Saltbr-out 14.7281 HRD-in -57.14, -59.8 81.96, -12.14 out-out-out SNCooo out-out ActLoopNT-out 10.7022 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -160.04, 114.16 APE9-dihe-na -79.94, 159.35 APE8-dihe-in -52.77, 143.91 APE8-rot-out 201.8 APE67-dihe-in -60.21, -14.42 -106.05, 1.41 APE12-dist-out 20.1478 APE11-dist-out 15.2393 APE10-dist-out 17.2957 APE9-dist-out 9.228 S298N,S299K,Y300F None None XRAY 1.9 0.165 999.0 A 360.0 315.0 29 26 26 0 [[68, 361]] 1.0 3eqi STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 5YT3C Q02750 40 382 393.0 ANP:401 ATPlike Inactive DFGin 5.7908 13.7388 BLBplus -158.87, 169.48 60.29, 28.47 -79.68, 102.42 54.67, 117.74 -64.84, 999.0 out-none out 15.4948 Saltbr-none 999.0 HRD-in -68.06, -45.57 70.46, -13.87 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 133.64 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 C 350.0 288.0 55 26 9 17 [[68, 361]] 1.0 5yt3 STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 6U2GA Q02750 43 383 393.0 ACP:901 ATPlike Inactive DFGin 5.8079 13.8406 BLBplus -143.7, 174.8 53.7, 47.78 -98.62, 156.52 46.78, 97.62 -76.59, 70.13 out-out out 15.3736 Saltbr-out 14.8686 HRD-in -83.28, -55.76 76.37, -10.26 out-out-out SNCooo out-out ActLoopNT-out 9.207 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -64.24, 146.48 APE9-dihe-na -101.23, -173.03 APE8-dihe-out -114.34, -9.62 APE8-rot-out 55.71 APE67-dihe-out -148.86, 141.69 -149.81, 176.75 APE12-dist-out 19.1865 APE11-dist-out 17.9815 APE10-dist-out 22.1053 APE9-dist-out 12.9996 None None None XRAY 2.886 0.231 0.276 A 394.0 309.0 32 26 26 0 [[68, 361]] 1.0 6u2g STE_MAP2K1_HUMAN STE 2.4e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 6V2WB Q02750 40 383 393.0 ANP:801 ATPlike Inactive DFGin 5.8394 13.8006 BLBplus -157.59, 169.08 49.06, 44.93 -84.24, 160.32 41.65, 89.8 -73.89, 81.99 out-out out 15.4976 Saltbr-out 15.9009 HRD-in -69.45, -57.02 68.3, 7.65 out-out-out SNCooo out-out ActLoopNT-out 8.701 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -54.4, 144.31 APE9-dihe-na -89.17, -161.86 APE8-dihe-out -115.14, -20.62 APE8-rot-out 48.82 APE67-dihe-out -139.36, 135.26 -146.31, 162.2 APE12-dist-out 17.533 APE11-dist-out 22.7363 APE10-dist-out 24.0164 APE9-dist-out 13.6453 S218A,S222A None None XRAY 3.12 0.189 0.237 B 397.0 312.0 32 26 26 0 [[68, 361]] 1.0 6v2w STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 4MNEA Q02750 63 379 393.0 ACP:901,573:903 ATPlike,Type1 Inactive DFGin 6.3821 13.6901 BLBplus -140.61, 176.72 54.72, 28.13 -81.46, 161.59 52.56, 86.0 -81.78, 73.09 out-out out 15.4969 Saltbr-out 15.7793 HRD-in -64.01, -56.53 90.31, -35.13 out-out-out SNCooo out-out ActLoopNT-out 9.2902 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -73.66, 137.78 APE9-dihe-na -84.79, 178.97 APE8-dihe-out -113.02, -24.38 APE8-rot-out 49.94 APE67-dihe-out -153.46, 146.56 -142.39, -172.52 APE12-dist-out 17.192 APE11-dist-out 21.6533 APE10-dist-out 23.7976 APE9-dist-out 13.4974 None None None XRAY 2.848 0.186 0.24 A 341.0 286.0 31 26 26 0 [[68, 361]] 1.0 4mne STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 4MNED Q02750 66 382 393.0 ACP:901,573:903 ATPlike,Type1 Inactive DFGin 6.2631 13.8726 BLBplus -124.78, 174.1 56.33, 33.25 -88.39, 154.28 50.46, 89.74 -73.02, 74.09 out-out out 15.5381 Saltbr-out 15.6141 HRD-in -64.9, -49.38 74.62, -12.51 out-out-out SNCooo out-out ActLoopNT-out 9.0432 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -65.65, 150.79 APE9-dihe-na -95.28, -163.25 APE8-dihe-out -122.75, -11.87 APE8-rot-out 68.42 APE67-dihe-out -159.06, 142.59 -161.08, -176.92 APE12-dist-out 17.403 APE11-dist-out 21.784 APE10-dist-out 23.8522 APE9-dist-out 13.6322 None None None XRAY 2.848 0.186 0.24 D 341.0 285.0 32 26 26 0 [[68, 361]] 1.0 4mne STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 8DGSB Q02750 38 383 393.0 AGS:60801,LCJ:60803 ATPlike,Type1 Inactive DFGin 6.249 12.9971 BLBplus -155.73, -179.02 61.68, 27.26 -72.39, 155.67 44.5, 85.53 -87.2, 64.42 out-out out 16.2947 Saltbr-out 16.06 HRD-in -62.57, -46.0 64.99, -4.53 out-out-out SNCooo out-out ActLoopNT-out 8.7094 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -122.25, 153.26 APE9-dihe-na -110.07, 177.24 APE8-dihe-out -99.46, -47.43 APE8-rot-out 69.24 APE67-dihe-out -133.48, 170.62 -132.77, 150.72 APE12-dist-out 17.1114 APE11-dist-out 20.5769 APE10-dist-out 22.9193 APE9-dist-out 13.2707 S218A,S222A None None EM 4.3 999.0 999.0 B 414.0 314.0 32 26 26 0 [[68, 361]] 1.0 8dgs STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 4AN3A Q02750 61 381 393.0 ATP:61383,5Y0:61384 ATPlike,Type3 Inactive DFGin 6.3723 14.221 BLBplus -129.12, 178.33 68.61, 30.98 -85.55, 168.03 44.05, 86.92 -96.2, 75.38 out-out out 15.6935 Saltbr-out 15.4163 HRD-in -67.68, -62.51 95.67, -17.38 out-out-out SNCooo out-out ActLoopNT-out 9.2297 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_onno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -140.36 APE8-dihe-in -98.61, 79.73 APE8-rot-in 326.73 APE67-dihe-in -67.76, -12.96 -73.18, -22.73 APE12-dist-out 17.69 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.352 S218E,S222E,G328A None None XRAY 2.1 0.229 0.283 A 301.0 277.0 2 26 24 2 [[68, 361]] 1.0 4an3 STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 4AN9A Q02750 61 381 393.0 ACP:61382,2P7:61384 ATPlike,Type3 Inactive DFGin 6.3107 13.7515 BLBplus -147.68, 174.84 72.25, 33.73 -84.91, 163.57 42.25, 107.87 -96.68, 81.85 out-out out 15.6879 Saltbr-out 15.1088 HRD-in -67.38, -51.77 90.36, -23.63 out-out-out SNCooo out-out ActLoopNT-out 9.4167 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_onoo APE10-dihe-na 999.0, 140.8 APE9-dihe-na -91.12, -166.68 APE8-dihe-in -63.03, 65.46 APE8-rot-in 350.49 APE67-dihe-in -61.1, -23.55 -42.53, -42.27 APE12-dist-out 17.6262 APE11-dist-none 999.0 APE10-dist-out 19.7035 APE9-dist-out 7.8575 S218E,S222E,G328A None None XRAY 2.8 0.205 0.313 A 301.0 278.0 1 26 25 1 [[68, 361]] 1.0 4an9 STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3SLSA Q02750 45 383 393.0 ANP:60400,77D:60500 ATPlike,Type3 Inactive DFGin 6.0671 13.8281 BLBplus -140.19, 178.66 54.09, 43.7 -94.25, 127.95 47.57, 97.28 -65.93, 145.27 out-out out 15.7649 Saltbr-out 16.2192 HRD-in -71.97, -60.22 78.51, -3.12 out-out-out SNCooo out-out ActLoopNT-out 8.4367 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nooo APE10-dihe-na -93.38, -0.96 APE9-dihe-na -118.58, -150.08 APE8-dihe-out -118.64, -9.13 APE8-rot-out 48.38 APE67-dihe-out -141.57, 136.87 -142.17, 156.77 APE12-dist-none 999.0 APE11-dist-out 20.7273 APE10-dist-out 20.2954 APE9-dist-out 13.9168 None None None XRAY 2.3 0.21 0.287 A 304.0 288.0 7 26 20 6 [[68, 361]] 1.0 3sls STE_MAP2K1_HUMAN STE 1.4e-98 335.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3SLSB Q02750 45 383 393.0 ANP:60400,77D:60500 ATPlike,Type3 Inactive DFGin 6.2211 13.8152 BLBplus -143.68, 175.58 56.27, 41.79 -94.32, 130.27 43.79, 91.06 -64.4, 146.65 out-out out 15.8164 Saltbr-out 15.9268 HRD-in -71.99, -58.98 74.88, -1.55 out-out-out SNCooo out-out ActLoopNT-out 7.5058 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nooo APE10-dihe-na -110.34, -17.81 APE9-dihe-na 107.94, -164.16 APE8-dihe-out -114.29, -25.66 APE8-rot-out 168.01 APE67-dihe-out -146.37, 136.37 -123.32, 171.0 APE12-dist-none 999.0 APE11-dist-out 19.1374 APE10-dist-out 21.3033 APE9-dist-out 13.5951 None None None XRAY 2.3 0.21 0.287 B 304.0 290.0 5 26 21 5 [[68, 361]] 1.0 3sls STE_MAP2K1_HUMAN STE 1.4e-98 335.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7B3MA Q02750 37 382 393.0 ANP:60402,SU5:60403 ATPlike,Type3 Inactive DFGin 6.1258 13.3704 BLBplus -148.65, 168.81 60.69, 38.17 -87.91, 154.07 39.86, 88.52 -71.49, 59.19 out-out out 15.3138 Saltbr-out 14.9939 HRD-in -70.73, -50.42 71.08, -9.53 out-out-out SNCooo out-out ActLoopNT-out 8.9548 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -121.3 APE8-dihe-out -86.65, -7.6 APE8-rot-out 192.68 APE67-dihe-out -130.89, 138.61 -149.99, 133.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.6751 None None None XRAY 2.3 0.22 0.268 A 326.0 297.0 5 26 21 5 [[68, 361]] 1.0 7b3m STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7B3MB Q02750 37 382 393.0 ANP:60402,SU5:60403 ATPlike,Type3 Inactive DFGin 6.095 13.3497 BLBplus -147.84, 168.76 59.95, 38.27 -86.94, 152.02 37.7, 89.9 -70.97, 59.7 out-out out 15.2643 Saltbr-out 14.844 HRD-in -70.51, -50.26 71.48, -11.7 out-out-out SNCooo out-out ActLoopNT-out 8.913 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -133.25 APE8-dihe-out -83.19, -28.76 APE8-rot-in 262.25 APE67-dihe-out -150.63, 137.62 -127.52, 158.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0843 None None None XRAY 2.3 0.22 0.268 B 326.0 298.0 4 26 22 4 [[68, 361]] 1.0 7b3m STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7B7RA Q02750 37 382 393.0 ANP:60401,T1K:60403 ATPlike,Type3 Inactive DFGin 6.1419 13.1685 BLBplus -135.79, 174.07 60.45, 39.3 -91.52, 155.87 43.71, 91.25 -77.25, 65.03 out-out out 15.2989 Saltbr-out 15.4643 HRD-in -68.45, -57.29 78.52, -6.73 out-out-out SNCooo out-out ActLoopNT-out 8.9351 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -104.92 APE8-dihe-out -68.21, -24.42 APE8-rot-out 184.14 APE67-dihe-out -122.45, 137.43 -138.43, 139.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.332 None None None XRAY 1.7 0.195 0.218 A 326.0 297.0 5 26 21 5 [[68, 361]] 1.0 7b7r STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7B7RB Q02750 39 382 393.0 ANP:60401,T1K:60403 ATPlike,Type3 Inactive DFGin 6.0337 13.1313 BLBplus -135.72, 177.16 59.39, 36.14 -85.12, 154.58 37.29, 94.77 -80.68, 71.22 out-out out 15.2953 Saltbr-out 15.3776 HRD-in -70.94, -55.67 77.08, -4.68 out-out-out SNCooo out-out ActLoopNT-out 8.8997 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -49.75 APE8-rot-out 171.35 APE67-dihe-out -144.02, 141.19 -140.4, 157.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.195 0.218 B 326.0 295.0 5 26 21 5 [[68, 361]] 1.0 7b7r STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7B94A Q02750 37 382 393.0 ANP:60401,T3W:60403 ATPlike,Type3 Inactive DFGin 5.9919 13.4781 BLBplus -132.63, 177.07 57.77, 37.37 -87.97, 156.39 42.38, 94.42 -75.9, 68.49 out-out out 15.5318 Saltbr-out 15.193 HRD-in -65.24, -55.1 71.13, -2.53 out-out-out SNCooo out-out ActLoopNT-out 8.8875 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.47 APE8-dihe-out -89.38, 6.07 APE8-rot-in 312.59 APE67-dihe-out -115.47, 140.44 -116.58, 113.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.5994 None None None XRAY 2.0 0.218 0.265 A 326.0 297.0 5 26 21 5 [[68, 361]] 1.0 7b94 STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7B94B Q02750 41 382 393.0 ANP:60401,T3W:60403 ATPlike,Type3 Inactive DFGin 5.8527 13.5104 BLBplus -134.32, 175.36 55.61, 39.25 -86.46, 153.65 39.68, 92.62 -72.74, 66.29 out-out out 15.1174 Saltbr-out 14.5478 HRD-in -66.3, -53.58 77.63, -11.98 out-out-out SNCooo out-out ActLoopNT-out 8.6174 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -40.61 APE8-rot-out 185.17 APE67-dihe-out -147.87, 139.4 -127.59, 154.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.218 0.265 B 326.0 293.0 5 26 21 5 [[68, 361]] 1.0 7b94 STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7B9LA Q02750 37 382 393.0 ANP:60401,T4N:60402 ATPlike,Type3 Inactive DFGin 6.1432 13.3849 BLBplus -137.56, 174.87 57.48, 45.06 -95.99, 156.93 43.03, 91.55 -78.34, 66.31 out-out out 15.2718 Saltbr-out 15.2434 HRD-in -67.86, -56.92 79.15, -7.52 out-out-none SNCoon out-none ActLoopNT-out 8.9677 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -119.38, 141.01 999.0, 135.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.194 0.214 A 326.0 295.0 7 26 19 7 [[68, 361]] 1.0 7b9l STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7B9LB Q02750 41 381 393.0 ANP:60401,T4N:60402 ATPlike,Type3 Inactive DFGin 5.9579 13.456 BLBplus -136.66, 175.43 56.67, 43.08 -92.39, 158.5 42.85, 91.66 -74.84, 62.99 out-out out 15.1558 Saltbr-out 14.9359 HRD-in -69.72, -56.61 80.29, -8.28 out-out-none SNCoon out-none ActLoopNT-out 8.6924 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -146.85, 137.07 999.0, 132.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.194 0.214 B 326.0 291.0 6 26 20 6 [[68, 361]] 1.0 7b9l STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3ORNA Q02750 62 380 393.0 ANP:60001,3OR:60400 ATPlike,Type3 Inactive DFGin 6.0287 13.8039 BLBplus -141.26, -171.81 51.14, 43.91 -94.56, 165.92 40.22, 96.28 -82.7, 73.49 out-out out 15.3451 Saltbr-out 15.2454 HRD-in -75.72, -51.63 76.11, -2.33 out-out-out SNCooo out-out ActLoopNT-out 9.2477 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -90.01, 161.45 APE9-dihe-na 75.09, 172.06 APE8-dihe-out -101.08, -27.15 APE8-rot-out 71.34 APE67-dihe-out -133.03, 139.32 -108.61, 153.73 APE12-dist-out 16.856 APE11-dist-out 20.6225 APE10-dist-out 18.5661 APE9-dist-out 13.0454 None None None XRAY 2.8 0.236 0.277 A 307.0 279.0 8 26 26 0 [[68, 361]] 1.0 3orn STE_MAP2K1_HUMAN STE 9.7e-99 335.8 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3OS3A Q02750 62 378 393.0 ATP:1,3OS:400 ATPlike,Type3 Inactive DFGin 6.2398 13.5344 BLBplus -145.24, 170.05 62.26, 36.89 -93.68, 158.58 44.13, 99.29 -73.81, 106.93 out-out out 15.5039 Saltbr-out 15.3944 HRD-in -59.5, -62.21 84.93, 3.41 out-out-out SNCooo out-out ActLoopNT-out 9.408 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -133.7, -173.12 APE9-dihe-na 93.3, -146.81 APE8-dihe-out -139.28, -26.49 APE8-rot-out 64.05 APE67-dihe-out 179.14, 100.5 -105.07, -165.97 APE12-dist-out 14.8647 APE11-dist-out 20.0987 APE10-dist-out 20.8465 APE9-dist-out 14.0001 None None None XRAY 2.8 0.268 0.356 A 307.0 272.0 13 26 26 0 [[68, 361]] 1.0 3os3 STE_MAP2K1_HUMAN STE 9.7e-99 335.8 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3WIGA Q02750 62 380 393.0 ANP:60401,CHU:60403 ATPlike,Type3 Inactive DFGin 6.2646 14.0156 BLBplus -143.18, 168.24 57.0, 43.27 -87.61, 167.58 35.17, 91.44 -81.11, 80.9 out-out out 15.2231 Saltbr-out 15.2345 HRD-in -81.12, -52.72 78.66, -9.66 out-out-out SNCooo out-out ActLoopNT-out 9.2519 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.56, 160.96 APE9-dihe-na 79.87, 168.49 APE8-dihe-out -95.77, -24.16 APE8-rot-out 58.57 APE67-dihe-out -134.06, 137.9 -112.83, 153.13 APE12-dist-out 16.5068 APE11-dist-out 20.1486 APE10-dist-out 18.5012 APE9-dist-out 12.9477 None None None XRAY 2.7 0.217 0.25 A 307.0 277.0 10 26 26 0 [[68, 361]] 1.0 3wig STE_MAP2K1_HUMAN STE 9.7e-99 335.8 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3DV3A Q02750 62 382 393.0 ATP:69000,MEK:69001 ATPlike,Type3 Inactive DFGin 6.2483 13.6028 BLBplus -133.16, -177.92 60.69, 33.15 -89.5, 161.32 45.46, 91.05 -72.95, 66.6 out-out out 15.44 Saltbr-out 15.9198 HRD-in -71.02, -56.25 85.34, -10.2 out-out-out SNCooo out-out ActLoopNT-out 9.4338 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 147.19 APE8-dihe-out -113.44, 8.55 APE8-rot-out 63.26 APE67-dihe-out -136.65, 142.85 -161.65, 147.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.7228 None None None XRAY 2.3 0.184 0.221 A 322.0 287.0 34 26 23 3 [[68, 361]] 1.0 3dv3 STE_MAP2K1_HUMAN STE 1.2e-97 332.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3MBLA Q02750 62 381 393.0 ADP:60535,LSG:60007 ATPlike,Type3 Inactive DFGin 6.3443 13.4033 BLBplus -137.82, 175.17 58.41, 36.59 -88.68, 159.6 41.78, 90.19 -90.36, 101.21 out-out out 15.5918 Saltbr-out 16.0041 HRD-in -72.77, -61.87 90.83, -9.53 out-out-out SNCooo out-out ActLoopNT-out 9.7788 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -62.62, 116.57 APE9-dihe-na -76.67, -13.86 APE8-dihe-out -100.19, -102.3 APE8-rot-out 48.6 APE67-dihe-out -109.33, 135.36 -59.01, 126.17 APE12-dist-out 18.7047 APE11-dist-out 17.8806 APE10-dist-out 19.945 APE9-dist-out 14.4728 None None None XRAY 2.6 0.169 0.215 A 328.0 289.0 31 26 26 0 [[68, 361]] 1.0 3mbl STE_MAP2K1_HUMAN STE 1.3e-97 332.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3PP1A Q02750 62 382 393.0 ATP:60400,IZG:60500 ATPlike,Type3 Inactive DFGin 6.2434 13.5326 BLBplus -142.73, -172.37 57.21, 29.66 -83.48, 161.89 45.19, 86.92 -94.1, 95.51 out-out out 15.5755 Saltbr-out 15.6643 HRD-in -75.88, -59.97 91.29, -12.92 out-out-out SNCooo out-out ActLoopNT-out 9.8367 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -95.93, 115.09 APE9-dihe-na -80.03, 20.28 APE8-dihe-out -149.74, -167.9 APE8-rot-out 183.56 APE67-dihe-out -104.62, 136.28 16.12, 99.01 APE12-dist-out 17.8027 APE11-dist-out 17.6574 APE10-dist-out 19.8725 APE9-dist-out 14.6223 None None None XRAY 2.7 0.184 0.219 A 328.0 290.0 31 26 26 0 [[68, 361]] 1.0 3pp1 STE_MAP2K1_HUMAN STE 1.3e-97 332.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3EQBA Q02750 62 382 393.0 ATP:69001,LUG:60001 ATPlike,Type3 Inactive DFGin 6.3666 13.8165 BLBplus -126.21, -166.87 50.54, 41.27 -103.19, 173.93 44.2, 81.11 -86.45, 70.56 out-out out 15.5513 Saltbr-out 16.0995 HRD-in -69.12, -59.32 92.15, -13.52 out-out-out SNCooo out-out ActLoopNT-out 9.4116 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -145.13 APE9-dihe-na 160.93, -130.46 APE8-dihe-out -134.08, -9.84 APE8-rot-out 185.08 APE67-dihe-out -100.78, 136.47 -136.54, 109.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.269 APE9-dist-out 13.0736 None None None XRAY 2.62 0.212 0.264 A 333.0 288.0 33 26 23 3 [[68, 361]] 1.0 3eqb STE_MAP2K1_HUMAN STE 1.4e-97 332.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 4U80A Q02750 62 379 393.0 ANP:60501,3EX:60502 ATPlike,Type3 Inactive DFGin 6.1423 13.3581 BLBplus -137.92, -179.3 57.25, 41.8 -100.21, 164.46 49.55, 87.81 -82.1, 69.9 out-out out 15.3907 Saltbr-out 16.1744 HRD-in -63.5, -60.19 86.1, -12.96 out-out-out SNCooo out-out ActLoopNT-out 9.1744 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, -56.89 APE9-dihe-na 91.88, -152.59 APE8-dihe-out -126.68, 10.89 APE8-rot-in 310.84 APE67-dihe-out -98.05, 140.26 -155.43, 115.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.5568 APE9-dist-out 13.4268 None None None XRAY 2.8 0.167 0.224 A 341.0 285.0 33 26 23 3 [[68, 361]] 1.0 4u80 STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 1S9JA Q02750 62 382 393.0 ATP:60535,BBM:61001 ATPlike,Type3 Inactive DFGin 6.0381 13.6765 BLBplus -128.29, 177.35 60.26, 51.07 -106.68, 166.27 42.89, 83.29 -88.36, 87.09 out-out out 15.6483 Saltbr-out 16.0046 HRD-in -74.19, -52.1 76.2, -2.79 out-out-out SNCooo out-out ActLoopNT-out 9.3469 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -65.48 APE9-dihe-na 93.04, 154.36 APE8-dihe-out -82.85, 11.58 APE8-rot-out 188.1 APE67-dihe-out -101.56, 129.66 -130.71, 111.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.1483 APE9-dist-out 12.5588 None None None XRAY 2.4 0.246 0.269 A 341.0 288.0 33 26 23 3 [[68, 361]] 1.0 1s9j STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3DY7A Q02750 62 364 393.0 ATP:9000,1CX:9002 ATPlike,Type3 Inactive DFGin 6.1717 13.7583 BLBplus -135.89, -175.79 54.31, 45.87 -100.93, 164.77 46.33, 84.08 -87.96, 76.55 out-out out 15.2441 Saltbr-out 15.5792 HRD-in -80.68, -50.01 86.81, -10.3 out-out-out SNCooo out-out ActLoopNT-out 9.4633 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -93.77 APE8-dihe-out -68.47, -78.94 APE8-rot-in 288.45 APE67-dihe-out -129.83, 139.32 -78.41, 146.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.0637 None None None XRAY 2.7 0.248 0.269 A 341.0 260.0 43 26 23 3 [[68, 361]] 1.0 3dy7 STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3E8NA Q02750 62 382 393.0 ATP:60600,VRA:61001 ATPlike,Type3 Inactive DFGin 6.1947 13.8185 BLBplus -141.11, 177.37 57.45, 45.25 -100.77, 153.06 46.07, 82.11 -71.63, 93.26 out-out out 15.4133 Saltbr-out 15.3475 HRD-in -66.77, -56.92 83.67, -13.1 out-out-out SNCooo out-out ActLoopNT-out 9.4321 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_onoo APE10-dihe-na 999.0, -90.03 APE9-dihe-na 88.43, 141.27 APE8-dihe-out -49.1, -69.8 APE8-rot-out 147.13 APE67-dihe-out -116.51, 140.9 -59.5, 122.62 APE12-dist-out 18.8826 APE11-dist-none 999.0 APE10-dist-out 19.9857 APE9-dist-out 12.8311 None None None XRAY 2.5 0.219 0.252 A 341.0 290.0 31 26 25 1 [[68, 361]] 1.0 3e8n STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3VVHA Q02750 62 382 393.0 ATP:60702,4BM:60703 ATPlike,Type3 Inactive DFGin 6.3887 13.6564 BLBplus -137.53, 173.5 63.48, 33.18 -82.96, 158.78 37.49, 96.63 -83.81, 69.64 out-out out 15.318 Saltbr-out 14.9475 HRD-in -72.04, -55.34 81.65, -10.46 out-out-out SNCooo out-out ActLoopNT-out 9.2611 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -67.32 APE8-rot-in 311.04 APE67-dihe-out -121.47, 130.33 -95.91, 138.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.199 0.225 A 341.0 286.0 35 26 21 5 [[68, 361]] 1.0 3vvh STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3VVHB Q02750 62 382 393.0 ATP:60502,4BM:60503 ATPlike,Type3 Inactive DFGin 6.1391 13.837 BLBplus -134.79, 175.55 59.54, 35.53 -87.99, 165.28 42.27, 92.99 -92.68, 76.34 out-out out 15.2611 Saltbr-out 14.9773 HRD-in -72.52, -58.36 78.03, -3.83 out-out-out SNCooo out-out ActLoopNT-out 9.105 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -110.08, 147.03 APE9-dihe-na 98.19, 168.29 APE8-dihe-out -85.55, -32.58 APE8-rot-in 303.1 APE67-dihe-out -124.7, 138.59 -110.8, 145.07 APE12-dist-out 16.9705 APE11-dist-out 20.5595 APE10-dist-out 18.8507 APE9-dist-out 12.9264 None None None XRAY 2.0 0.199 0.225 B 341.0 289.0 32 26 26 0 [[68, 361]] 1.0 3vvh STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3VVHC Q02750 62 381 393.0 ATP:60502,4BM:60503 ATPlike,Type3 Inactive DFGin 6.1194 13.8842 BLBplus -136.04, 173.19 62.4, 33.8 -87.32, 164.72 43.72, 90.03 -81.06, 61.43 out-out out 15.3952 Saltbr-out 14.9059 HRD-in -71.92, -60.52 80.82, -10.24 out-out-out SNCooo out-out ActLoopNT-out 9.0055 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -107.33, 145.59 APE9-dihe-na 98.43, 176.47 APE8-dihe-out -99.48, -17.12 APE8-rot-out 62.73 APE67-dihe-out -124.21, 136.5 -120.29, 144.56 APE12-dist-out 16.9183 APE11-dist-out 20.6229 APE10-dist-out 18.8043 APE9-dist-out 12.9647 None None None XRAY 2.0 0.199 0.225 C 341.0 282.0 38 26 26 0 [[68, 361]] 1.0 3vvh STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 4ARKA Q02750 62 382 393.0 ADP:61383,M3K:61385 ATPlike,Type3 Inactive DFGin 6.213 13.3205 BLBplus -143.7, -171.53 62.76, 23.96 -76.11, 159.51 42.79, 94.02 -85.45, 75.28 out-out out 15.3534 Saltbr-out 15.901 HRD-in -67.47, -65.14 92.89, -4.81 out-out-out SNCooo out-out ActLoopNT-out 9.3292 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -100.98, -15.83 APE9-dihe-na -32.88, 128.59 APE8-dihe-out -40.11, 20.06 APE8-rot-out 186.45 APE67-dihe-out -132.58, 138.09 -155.02, 124.88 APE12-dist-out 16.3492 APE11-dist-out 18.1392 APE10-dist-out 23.5537 APE9-dist-out 14.4262 None None None XRAY 2.6 0.174 0.211 A 341.0 290.0 31 26 26 0 [[68, 361]] 1.0 4ark STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 4LMNA Q02750 62 382 393.0 ANP:60501,EUI:60503 ATPlike,Type3 Inactive DFGin 6.1087 13.4073 BLBplus -150.33, -178.45 56.52, 30.25 -84.69, 155.37 45.37, 87.33 -80.58, 74.43 out-out out 15.5596 Saltbr-out 15.7763 HRD-in -60.71, -57.05 86.56, -12.8 out-out-out SNCooo out-out ActLoopNT-out 9.0127 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.36, -106.55 APE9-dihe-na -110.69, -4.9 APE8-dihe-out -94.39, -2.53 APE8-rot-out 38.79 APE67-dihe-out -120.37, 128.01 -144.86, 111.2 APE12-dist-out 20.4741 APE11-dist-out 19.7321 APE10-dist-out 22.049 APE9-dist-out 15.3113 None None None XRAY 2.8 0.193 0.233 A 341.0 291.0 30 26 26 0 [[68, 361]] 1.0 4lmn STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 4MNEE Q02750 62 379 393.0 ACP:901,573:903 ATPlike,Type3 Inactive DFGin 6.3012 13.7407 BLBplus -139.17, 176.14 61.58, 40.21 -96.23, 153.1 47.97, 96.35 -69.87, 64.71 out-out out 15.7956 Saltbr-out 16.1573 HRD-in -84.17, -39.22 69.48, -27.4 out-out-out SNCooo out-out ActLoopNT-out 9.2771 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -76.04, 124.0 APE9-dihe-na -78.04, -178.79 APE8-dihe-out -111.0, -36.1 APE8-rot-out 69.56 APE67-dihe-out -140.43, 146.63 -132.48, 167.21 APE12-dist-out 17.6629 APE11-dist-out 21.7751 APE10-dist-out 24.2369 APE9-dist-out 13.5531 None None None XRAY 2.848 0.186 0.24 E 341.0 286.0 32 26 26 0 [[68, 361]] 1.0 4mne STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3EQGA Q02750 39 381 393.0 ADP:2,4BM:1 ATPlike,Type3 Inactive DFGin 6.6055 13.7427 BLBplus -138.18, 179.2 59.31, 28.5 -81.55, 153.56 35.8, 92.23 -71.67, 64.14 out-out out 15.4736 Saltbr-out 14.5657 HRD-in -60.95, -65.33 94.63, -12.32 out-out-out SNCooo out-out ActLoopNT-out 9.2307 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -104.38, 152.44 APE9-dihe-na -137.47, 114.08 APE8-dihe-in -13.21, 123.19 APE8-rot-out 216.51 APE67-dihe-in -71.17, -7.71 -101.04, 15.41 APE12-dist-out 19.79 APE11-dist-out 16.5602 APE10-dist-out 18.8547 APE9-dist-out 9.489 S298N,S299K,Y300F None None XRAY 2.5 0.21 0.273 A 360.0 314.0 29 26 26 0 [[68, 361]] 1.0 3eqg STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7UMBC Q02750 41 381 393.0 ANP:401,U9F:402 ATPlike,Type3 Inactive DFGin 6.169 13.7668 BLBplus -162.24, 171.11 70.21, 49.7 -113.95, 160.88 44.65, 94.08 -79.06, 81.13 out-out out 15.5589 Saltbr-out 15.2725 HRD-in -66.12, -48.09 76.83, -9.86 out-out-out SNCooo out-out ActLoopNT-out 9.5911 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -127.94, 139.36 APE9-dihe-na -138.86, -160.81 APE8-dihe-out -82.2, -18.64 APE8-rot-out 50.9 APE67-dihe-out -106.39, 139.13 -104.8, 110.61 APE12-dist-out 16.6992 APE11-dist-out 19.6656 APE10-dist-out 21.5701 APE9-dist-out 14.915 None None None XRAY 3.231 0.231 0.268 C 384.0 303.0 38 26 26 0 [[68, 361]] 1.0 7umb STE_MAP2K1_HUMAN STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 6PP9B Q02750 38 383 393.0 ANP:801,LCJ:803 ATPlike,Type3 Inactive DFGin 6.0507 13.8503 BLBplus -152.52, 171.62 57.53, 41.01 -92.48, 164.33 45.1, 87.01 -81.4, 67.83 out-out out 15.4693 Saltbr-out 15.3255 HRD-in -69.19, -57.7 73.02, -1.06 out-out-out SNCooo out-out ActLoopNT-out 8.325 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -150.75, 155.46 APE9-dihe-na -104.35, -179.3 APE8-dihe-out -103.86, -21.71 APE8-rot-out 60.0 APE67-dihe-out -161.36, 138.21 -120.01, -175.99 APE12-dist-out 17.6293 APE11-dist-out 18.0984 APE10-dist-out 21.1907 APE9-dist-out 12.1845 S218A,S222A None None XRAY 2.59 0.222 0.245 B 397.0 314.0 32 26 26 0 [[68, 361]] 1.0 6pp9 STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7M0VB Q02750 42 383 393.0 ANP:801,EUI:803 ATPlike,Type3 Inactive DFGin 6.0381 13.7379 BLBplus -152.98, 176.74 51.89, 40.05 -97.58, 155.01 48.54, 94.68 -74.32, 76.65 out-out out 15.3562 Saltbr-out 15.2475 HRD-in -53.62, -41.23 79.48, -8.01 out-out-out SNCooo out-out ActLoopNT-out 8.4508 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -59.78, 136.18 APE9-dihe-na -90.07, -164.06 APE8-dihe-out -111.55, -13.91 APE8-rot-out 80.18 APE67-dihe-out -157.27, 123.12 -113.49, 175.2 APE12-dist-out 17.7535 APE11-dist-out 19.5873 APE10-dist-out 21.2162 APE9-dist-out 13.438 S218A,S222A None None XRAY 3.16 0.188 0.234 B 397.0 310.0 32 26 26 0 [[68, 361]] 1.0 7m0v STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7M0WB Q02750 42 383 393.0 ANP:801,QOA:803 ATPlike,Type3 Inactive DFGin 6.1482 14.0545 BLBplus -157.1, -177.15 57.47, 39.21 -94.37, 139.97 49.64, 89.26 -60.24, 75.28 out-out out 15.239 Saltbr-out 15.1806 HRD-in -60.24, -53.72 67.58, 4.61 out-out-out SNCooo out-out ActLoopNT-out 8.8656 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -57.72, 142.94 APE9-dihe-na -85.2, -169.93 APE8-dihe-out -102.45, -22.28 APE8-rot-out 37.77 APE67-dihe-out -129.82, 144.3 -151.67, 158.88 APE12-dist-out 17.5121 APE11-dist-out 22.6571 APE10-dist-out 23.4774 APE9-dist-out 13.5899 S218A,S222A None None XRAY 3.09 0.197 0.233 B 397.0 310.0 32 26 26 0 [[68, 361]] 1.0 7m0w STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7M0XB Q02750 40 383 393.0 ANP:801,4BM:803 ATPlike,Type3 Inactive DFGin 6.0399 13.7075 BLBplus -145.13, 173.52 62.48, 32.29 -85.3, 166.26 43.84, 89.91 -82.62, 63.8 out-out out 15.2193 Saltbr-out 15.1277 HRD-in -57.93, -57.46 71.94, -0.74 out-out-out SNCooo out-out ActLoopNT-out 8.3308 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.02, 147.44 APE9-dihe-na -87.47, -179.23 APE8-dihe-out -111.82, -15.11 APE8-rot-out 56.07 APE67-dihe-out -151.04, 140.91 -141.23, 175.81 APE12-dist-out 17.7952 APE11-dist-out 17.9191 APE10-dist-out 21.3926 APE9-dist-out 11.9857 S218A,S222A None None XRAY 2.47 0.18 0.215 B 397.0 312.0 32 26 26 0 [[68, 361]] 1.0 7m0x STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7M0YB Q02750 43 382 393.0 ANP:401,QOM:404 ATPlike,Type3 Inactive DFGin 5.9314 13.9674 BLBplus -158.94, 162.56 56.25, 36.06 -89.69, 147.0 54.27, 82.92 -67.13, 108.1 out-out out 15.4927 Saltbr-out 15.9617 HRD-in -58.74, -61.39 74.04, 6.51 out-out-out SNCooo out-out ActLoopNT-out 9.4018 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -63.76, 140.76 APE9-dihe-na -82.11, -165.89 APE8-dihe-out -109.48, -23.44 APE8-rot-out 48.75 APE67-dihe-out -133.69, 134.38 -151.5, 158.4 APE12-dist-out 17.3805 APE11-dist-out 22.4528 APE10-dist-out 23.379 APE9-dist-out 13.66 S218A,S222A None None XRAY 3.45 0.196 0.218 B 397.0 308.0 32 26 26 0 [[68, 361]] 1.0 7m0y STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7M0ZB Q02750 42 383 393.0 ANP:401,CHU:402 ATPlike,Type3 Inactive DFGin 6.1064 14.1069 BLBplus -160.77, 175.85 59.87, 41.63 -97.41, 152.84 45.88, 80.73 -66.99, 92.55 out-out out 15.4927 Saltbr-out 15.371 HRD-in -96.91, -40.79 69.65, -8.88 out-out-out SNCooo out-out ActLoopNT-out 9.612 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -66.4, 138.99 APE9-dihe-na -84.75, -165.15 APE8-dihe-out -106.74, -38.37 APE8-rot-out 38.19 APE67-dihe-out -129.38, 138.55 -136.73, 157.33 APE12-dist-out 17.2133 APE11-dist-out 22.3822 APE10-dist-out 23.6126 APE9-dist-out 13.6034 S218A,S222A None None XRAY 3.12 0.193 0.225 B 397.0 310.0 32 26 26 0 [[68, 361]] 1.0 7m0z STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 8DGTB Q02750 43 385 393.0 AGS:60402,LCJ:60403 ATPlike,Type3 Inactive DFGin 5.9682 13.5357 BLBplus -152.99, 179.37 55.42, 45.61 -100.12, 157.06 44.99, 96.32 -80.94, 77.56 out-out out 15.5691 Saltbr-out 15.7331 HRD-in -64.15, -51.45 68.84, -11.98 out-out-out SNCooo out-out ActLoopNT-out 8.9452 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -67.75, 131.31 APE9-dihe-na -82.42, -172.83 APE8-dihe-out -101.84, -12.18 APE8-rot-out 77.74 APE67-dihe-out -124.11, 144.61 -162.74, 152.77 APE12-dist-out 16.6735 APE11-dist-out 21.6272 APE10-dist-out 23.2855 APE9-dist-out 13.7054 S218A,S222A None None EM 3.9 999.0 999.0 B 414.0 311.0 32 26 26 0 [[68, 361]] 1.0 8dgt STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 6NYBB Q02750 56 383 393.0 ADP:60601,LCJ:60901 ATPlike,Type3 Inactive DFGin 5.9588 14.0365 BLBplus -152.28, 170.52 57.47, 42.76 -92.93, 161.49 47.46, 85.53 -88.41, 68.49 out-out out 15.4696 Saltbr-out 17.6022 HRD-in -56.15, -54.04 65.39, 11.35 out-out-out SNCooo out-out ActLoopNT-out 8.2916 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.81, 127.27 APE9-dihe-na -93.66, 157.79 APE8-dihe-out -110.82, -26.16 APE8-rot-out 55.56 APE67-dihe-out -130.29, 148.43 -119.13, 133.87 APE12-dist-out 17.78 APE11-dist-out 18.3191 APE10-dist-out 22.3789 APE9-dist-out 12.1589 S218A,S222A None None EM 4.1 999.0 999.0 B 415.0 289.0 39 26 26 0 [[68, 361]] 1.0 6nyb STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9MMPB Q02750 62 380 393.0 AGS:60701,LCJ:60702 ATPlike,Type3 Inactive DFGin 6.4937 13.7015 BLBplus -142.17, 163.3 59.56, 65.37 -113.14, 157.69 39.56, 95.33 -79.99, 73.26 out-out out 15.7564 Saltbr-out 16.3325 HRD-in -69.63, -60.91 71.6, -9.27 out-out-out SNCooo out-out ActLoopNT-out 8.0011 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -73.57, 130.1 APE9-dihe-na -94.62, 178.33 APE8-dihe-out -96.1, -46.02 APE8-rot-in 278.39 APE67-dihe-out -136.63, 147.99 -117.77, 157.18 APE12-dist-out 17.2275 APE11-dist-out 22.2405 APE10-dist-out 24.3959 APE9-dist-out 13.7692 S218A,S222A None None EM 3.4 999.0 999.0 B 415.0 279.0 40 26 26 0 [[68, 361]] 1.0 9mmp STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9MMQB Q02750 62 380 393.0 AGS:701,LCJ:703 ATPlike,Type3 Inactive DFGin 6.6749 13.4889 BLBplus -138.6, 170.41 60.57, 44.79 -97.28, 158.99 35.24, 93.11 -75.64, 83.14 out-out out 15.4214 Saltbr-out 15.6346 HRD-in -61.2, -52.92 69.79, -9.3 out-out-out SNCooo out-out ActLoopNT-out 9.0103 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -65.78, 148.58 APE9-dihe-na -99.52, -176.8 APE8-dihe-out -104.42, -44.51 APE8-rot-in 299.56 APE67-dihe-out -150.89, 153.99 -135.56, 174.2 APE12-dist-out 17.2664 APE11-dist-out 22.0929 APE10-dist-out 24.0771 APE9-dist-out 13.54 S218A,S222A None None EM 2.9 999.0 999.0 B 415.0 279.0 40 26 26 0 [[68, 361]] 1.0 9mmq STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9MMRB Q02750 62 380 393.0 AGS:60701,LCJ:60703 ATPlike,Type3 Inactive DFGin 6.847 13.5448 BLBplus -144.47, 166.22 62.86, 45.64 -102.79, 155.22 38.56, 95.23 -78.03, 72.6 out-out out 15.3255 Saltbr-out 15.7338 HRD-in -59.38, -50.94 68.52, -2.49 out-out-out SNCooo out-out ActLoopNT-out 8.9519 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -61.82, 155.36 APE9-dihe-na -107.83, -179.82 APE8-dihe-out -105.89, -53.41 APE8-rot-in 308.85 APE67-dihe-out -136.82, 148.35 -127.86, 156.49 APE12-dist-out 17.0348 APE11-dist-out 22.0064 APE10-dist-out 24.0306 APE9-dist-out 13.5803 S218A,S222A None None EM 3.9 999.0 999.0 B 415.0 279.0 40 26 26 0 [[68, 361]] 1.0 9mmr STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9MMSB Q02750 63 380 393.0 AGS:701,LCJ:703 ATPlike,Type3 Inactive DFGin 6.8547 13.563 BLBplus -141.52, 164.23 63.42, 46.21 -99.5, 165.31 34.19, 90.42 -80.53, 73.26 out-out out 15.4077 Saltbr-out 15.7694 HRD-in -66.2, -52.71 70.98, -11.79 out-out-out SNCooo out-out ActLoopNT-out 8.8575 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -63.41, 150.0 APE9-dihe-na -102.92, -178.46 APE8-dihe-out -108.1, -35.69 APE8-rot-in 324.75 APE67-dihe-out -152.78, 143.47 -133.76, 175.52 APE12-dist-out 17.2823 APE11-dist-out 22.2166 APE10-dist-out 24.3527 APE9-dist-out 13.6751 S218A,S222A None None EM 3.3 999.0 999.0 B 415.0 278.0 40 26 26 0 [[68, 361]] 1.0 9mms STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 4MNEH Q02750 66 380 393.0 ACP:901,573:903,573:904 ATPlike,Type3,Allosteric Inactive DFGin 6.3776 13.8909 BLBplus -149.03, 175.24 52.75, 36.33 -93.4, 157.98 53.98, 84.28 -78.54, 56.84 out-out out 15.8147 Saltbr-out 15.4559 HRD-in -72.48, -51.28 80.05, -1.12 out-out-out SNCooo out-out ActLoopNT-out 9.1113 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -63.87, 146.83 APE9-dihe-na -98.86, 164.39 APE8-dihe-out -71.61, -59.39 APE8-rot-in 294.12 APE67-dihe-out -156.42, 156.79 -128.0, -169.25 APE12-dist-out 17.7474 APE11-dist-out 21.8877 APE10-dist-out 24.1565 APE9-dist-out 13.6645 None None None XRAY 2.848 0.186 0.24 H 341.0 275.0 40 26 26 0 [[68, 361]] 1.0 4mne STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9AXMC Q02750 43 376 393.0 A1AHE:60401 Type1 Inactive DFGin 6.668 14.1318 BLBplus -150.29, 169.67 59.1, 61.29 -116.51, 166.39 40.92, 86.38 -72.68, 94.97 out-none out 15.3794 Saltbr-none 999.0 HRD-in -102.21, -42.14 67.4, -10.68 none-out-out SNCnoo out-out ActLoopNT-out 9.7501 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -64.72, 121.05 APE9-dihe-na -67.96, 179.71 APE8-dihe-out -110.15, -27.15 APE8-rot-out 56.89 APE67-dihe-out -127.4, 134.54 -138.28, 164.48 APE12-dist-out 17.1619 APE11-dist-out 22.1776 APE10-dist-out 24.2389 APE9-dist-out 13.2396 S218A,S222A None None XRAY 2.42 0.263 0.301 C 310.0 290.0 0 26 26 0 [[68, 361]] 1.0 9axm STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7PQVA Q02750 39 382 393.0 80C:401 Type1 Inactive DFGin 5.4336 14.6802 BLBplus -142.2, 171.85 61.45, 42.08 -85.79, 152.48 48.85, 90.13 -67.98, 114.43 out-out out 15.5242 Saltbr-out 14.5103 HRD-in -71.75, -53.29 78.98, -5.23 out-out-out SNCooo out-out ActLoopNT-out 10.8553 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -72.38 APE9-dihe-na -75.93, 162.49 APE8-dihe-in -64.45, 139.43 APE8-rot-out 186.6 APE67-dihe-in -68.45, -13.06 -104.01, 6.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.4546 APE9-dist-out 9.4566 None None None XRAY 2.13 0.239 0.287 A 344.0 310.0 34 26 23 3 [[68, 361]] 1.0 7pqv STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3ZLSA Q02750 39 382 393.0 92P:1383 Type1 Inactive DFGin 6.349 13.9016 BLBplus -142.39, 168.81 61.5, 49.05 -105.64, 135.16 48.47, 88.72 -55.27, 109.43 out-out out 15.2616 Saltbr-out 14.1732 HRD-in -68.12, -60.88 87.92, -13.42 out-out-out SNCooo out-out ActLoopNT-out 10.7509 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -114.56, 4.84 APE9-dihe-na 122.52, 156.26 APE8-dihe-in -53.81, 153.4 APE8-rot-out 184.69 APE67-dihe-in -61.22, -14.41 -106.03, 1.34 APE12-dist-out 17.359 APE11-dist-out 18.4642 APE10-dist-out 12.8015 APE9-dist-out 9.1826 S298N,S299K,Y300K None None XRAY 2.5 0.195 0.234 A 348.0 315.0 29 26 26 0 [[68, 361]] 1.0 3zls STE_MAP2K1_HUMAN STE 1.6e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3ZLXA Q02750 39 382 393.0 5EZ:1383 Type1 Inactive DFGin 6.1026 14.1175 BLBplus -137.36, 173.38 56.89, 45.75 -94.74, 137.54 39.99, 92.63 -59.78, 119.2 out-out out 15.3878 Saltbr-out 14.8632 HRD-in -65.83, -55.53 80.52, -17.62 out-out-out SNCooo out-out ActLoopNT-out 10.9147 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -19.39 APE9-dihe-na -73.81, 148.26 APE8-dihe-in -58.02, 134.08 APE8-rot-out 188.84 APE67-dihe-in -64.06, -14.63 -102.54, 3.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.7919 APE9-dist-out 9.3167 S298N,S299K,Y300K None None XRAY 2.2 0.205 0.236 A 348.0 312.0 32 26 23 3 [[68, 361]] 1.0 3zlx STE_MAP2K1_HUMAN STE 1.6e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3ZM4A Q02750 40 382 393.0 22T:1383 Type1 Inactive DFGin 6.0389 13.8066 BLBplus -136.85, 171.85 55.05, 56.56 -104.8, 123.38 44.97, 93.25 -61.01, 124.18 out-out out 15.2158 Saltbr-out 15.3474 HRD-in -60.66, -53.09 74.75, -8.66 out-out-out SNCooo out-out ActLoopNT-out 11.019 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 152.25 APE8-dihe-in -64.64, 144.96 APE8-rot-out 192.59 APE67-dihe-in -62.95, -15.23 -105.08, 3.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.3981 S298N,S299K,Y300K None None XRAY 2.37 0.207 0.241 A 348.0 309.0 34 26 22 4 [[68, 361]] 1.0 3zm4 STE_MAP2K1_HUMAN STE 1.6e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 5BX0A Q02750 39 382 393.0 4W5:4000 Type1 Inactive DFGin 6.9984 13.7672 BLBplus -136.8, 170.44 43.31, 54.65 -106.61, 136.84 50.08, 96.97 -61.42, 106.18 out-out out 14.9264 Saltbr-out 13.5457 HRD-in -68.32, -52.05 72.06, 2.25 out-out-out SNCooo out-out ActLoopNT-out 10.0285 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na 57.15, 101.55 APE9-dihe-na -59.91, 145.17 APE8-dihe-in -61.27, 132.45 APE8-rot-out 189.37 APE67-dihe-in -64.93, -20.22 -94.27, 3.12 APE12-dist-out 16.3413 APE11-dist-out 15.576 APE10-dist-out 16.6316 APE9-dist-out 8.1509 None None None XRAY 2.93 0.2 0.252 A 348.0 315.0 29 26 26 0 [[68, 361]] 1.0 5bx0 STE_MAP2K1_HUMAN STE 1.6e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7XNCA Q02750 37 382 393.0 GIK:401 Type1 Inactive DFGin 5.8947 14.8252 BLBplus -156.03, 175.21 61.47, 34.29 -87.45, 138.03 47.2, 91.86 -58.36, 113.33 out-out out 15.4222 Saltbr-out 14.2443 HRD-in -73.45, -50.27 75.24, -7.95 out-out-out SNCooo out-out ActLoopNT-out 10.6397 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 172.59 APE9-dihe-na -67.78, 157.57 APE8-dihe-in -67.44, 146.19 APE8-rot-out 185.87 APE67-dihe-in -70.1, -4.65 -109.72, 7.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.2585 APE9-dist-out 9.409 S298N,S299K,Y300K None None XRAY 2.1 0.227 0.251 A 348.0 311.0 35 26 23 3 [[68, 361]] 1.0 7xnc STE_MAP2K1_HUMAN STE 1.6e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3ZLYA Q02750 40 382 393.0 YSO:1383 Type1 Inactive DFGin 6.0219 13.9264 BLBplus -136.5, 174.92 53.79, 50.97 -96.94, 123.0 39.07, 92.61 -57.89, 125.23 out-out out 15.3139 Saltbr-out 14.8952 HRD-in -64.76, -55.59 79.69, -12.84 out-out-out SNCooo out-out ActLoopNT-out 10.9518 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 59.75 APE9-dihe-na -59.24, 161.77 APE8-dihe-in -58.7, 148.28 APE8-rot-out 187.92 APE67-dihe-in -66.68, -11.75 -105.31, 5.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.0996 APE9-dist-out 9.5312 S298N,S299N,Y300K None None XRAY 2.11 0.201 0.248 A 348.0 310.0 33 26 23 3 [[68, 361]] 1.0 3zly STE_MAP2K1_HUMAN STE 1.6e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 5EYMA Q02750 41 381 393.0 5U5:401 Type1 Inactive DFGin 6.0591 15.6595 BLBplus -120.98, 147.02 60.26, 74.87 -99.88, 172.08 67.77, 94.18 -95.96, 104.23 out-out out 14.9434 Saltbr-out 14.6369 HRD-out -97.04, 164.44 -129.86, 87.96 out-out-out SNCooo out-out ActLoopNT-out 9.8393 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 170.38 APE8-rot-out 191.89 APE67-dihe-in -94.98, 9.32 -122.76, 22.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S298N,S299K,Y300F None None XRAY 2.7 0.247 0.308 A 359.0 292.0 49 26 20 6 [[68, 361]] 1.0 5eym STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 5EYMB Q02750 41 381 393.0 5U5:401 Type1 Inactive DFGin 5.8473 15.517 BLBplus -137.53, 139.28 62.1, 82.03 -101.81, 135.65 61.97, 95.79 -72.99, 85.77 out-out out 14.8463 Saltbr-out 13.9051 HRD-out -85.96, 166.94 -128.86, 78.44 out-out-out SNCooo out-out ActLoopNT-out 9.7495 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 169.8 APE8-rot-out 190.32 APE67-dihe-in -105.42, 16.51 -133.2, 32.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S298N,S299K,Y300F None None XRAY 2.7 0.247 0.308 B 359.0 292.0 49 26 20 6 [[68, 361]] 1.0 5eym STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3EQFA Q02750 39 381 393.0 KSA:1 Type1 Inactive DFGin 6.2432 13.6637 BLBplus -153.33, 163.29 80.11, 34.98 -102.11, 118.04 52.83, 85.59 -46.9, 139.99 out-out out 14.5589 Saltbr-out 13.0772 HRD-in -93.89, -53.62 76.18, 0.04 out-out-out SNCooo out-out ActLoopNT-out 10.9093 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -158.82, 130.87 APE9-dihe-na -108.44, 177.3 APE8-dihe-in -83.48, 167.0 APE8-rot-out 171.06 APE67-dihe-in -59.57, -9.61 -127.22, 12.73 APE12-dist-out 19.7055 APE11-dist-out 14.97 APE10-dist-out 17.1123 APE9-dist-out 9.569 S298N,S299K,Y300F None None XRAY 2.7 0.257 999.0 A 360.0 314.0 29 26 26 0 [[68, 361]] 1.0 3eqf STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9O0UB Q02750 30 380 393.0 CHU:401 Type1 Inactive DFGin 6.1693 14.0852 BLBplus -152.21, 168.43 59.39, 48.73 -101.51, 163.52 46.19, 86.69 -79.7, 84.36 out-out out 15.4302 Saltbr-out 16.8168 HRD-in -71.69, -48.17 74.87, -6.64 out-out-out SNCooo out-out ActLoopNT-out 9.681 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -135.55, 157.08 APE9-dihe-na -122.47, 145.42 APE8-dihe-out -102.69, -27.28 APE8-rot-in 280.53 APE67-dihe-out -148.15, 135.27 -137.0, 174.84 APE12-dist-out 16.861 APE11-dist-out 17.0165 APE10-dist-out 21.8105 APE9-dist-out 12.4425 S218A,S222A None None XRAY 2.91 0.232 0.264 B 395.0 322.0 29 26 26 0 [[68, 361]] 1.0 9o0u STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3ZLWA Q02750 39 382 393.0 MT8:1383 Type1 Inactive DFGin 6.1457 14.2171 BLBplus -141.88, 175.47 52.4, 41.68 -90.51, 130.61 42.74, 93.08 -63.08, 114.26 out-out out 15.481 Saltbr-out 14.3533 HRD-in -65.75, -51.92 80.2, -17.86 out-out-out SNCooo out-out ActLoopNT-out 10.9546 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 36.62 APE9-dihe-na -53.09, 161.09 APE8-dihe-in -56.49, 143.1 APE8-rot-out 192.65 APE67-dihe-in -68.31, -12.99 -103.26, 6.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.0559 APE9-dist-out 9.5048 S298N,S299K,Y300F None None XRAY 2.12 0.198 0.248 A 348.0 312.0 32 26 23 3 [[68, 361]] 1.0 3zlw STE_MAP2K1_HUMAN STE 5.8e-96 326.8 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9AXHA Q02750 39 381 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.113 14.2053 BLBplus -138.52, 176.84 56.32, 45.26 -98.43, 166.79 48.45, 76.71 -79.29, 73.17 out-out out 15.3891 Saltbr-out 15.4608 HRD-in -79.27, -55.22 75.38, 2.3 out-out-out SNCooo out-out ActLoopNT-out 9.3908 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -141.27, 126.74 APE9-dihe-na -91.23, -150.48 APE8-dihe-out -108.84, -16.83 APE8-rot-out 178.7 APE67-dihe-out -130.79, 128.8 -115.86, 151.78 APE12-dist-out 17.4166 APE11-dist-out 17.6237 APE10-dist-out 20.8985 APE9-dist-out 13.1543 None None None XRAY 2.81 0.206 0.253 A 310.0 299.0 0 26 26 0 [[68, 361]] 1.0 9axh STE_MAP2K1_HUMAN STE 1.5e-98 335.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9AXHB Q02750 38 381 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.0283 13.959 BLBplus -143.4, 172.79 59.61, 49.11 -104.03, 163.1 47.48, 79.51 -74.37, 70.81 out-out out 15.4154 Saltbr-out 14.8168 HRD-in -76.49, -58.47 81.39, -4.23 out-out-out SNCooo out-out ActLoopNT-out 9.3218 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.95, 129.53 APE9-dihe-na -95.7, -172.17 APE8-dihe-out -83.87, -23.26 APE8-rot-out 67.32 APE67-dihe-out -134.03, 129.22 -119.03, 156.34 APE12-dist-out 17.3071 APE11-dist-out 17.5745 APE10-dist-out 20.8998 APE9-dist-out 12.718 None None None XRAY 2.81 0.206 0.253 B 310.0 300.0 0 26 26 0 [[68, 361]] 1.0 9axh STE_MAP2K1_HUMAN STE 1.5e-98 335.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9AXMA Q02750 38 382 393.0 A1AHE:60401,ANP:60403 Type1,ATPlike Inactive DFGin 6.2039 13.9992 BLBplus -146.84, 170.95 57.84, 58.3 -113.46, 158.4 47.1, 81.42 -71.93, 78.64 out-out out 15.4263 Saltbr-out 15.5133 HRD-in -80.25, -54.29 71.05, 3.5 out-out-out SNCooo out-out ActLoopNT-out 9.1102 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -58.81, 135.38 APE9-dihe-na -86.44, -174.93 APE8-dihe-out -114.7, -19.48 APE8-rot-out 61.33 APE67-dihe-out -156.42, 133.96 -137.25, 175.14 APE12-dist-out 17.3471 APE11-dist-out 22.1228 APE10-dist-out 24.2234 APE9-dist-out 13.2409 S218A,S222A None None XRAY 2.42 0.263 0.301 A 310.0 301.0 0 26 26 0 [[68, 361]] 1.0 9axm STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9AXXA Q02750 41 382 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.1565 14.4729 BLBplus -142.21, 167.57 61.94, 40.19 -92.82, 170.58 38.95, 89.02 -82.21, 74.48 out-out out 15.9248 Saltbr-out 15.6608 HRD-in -77.34, -56.94 85.02, -11.71 out-out-out SNCooo out-out ActLoopNT-out 9.6225 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -70.01, 140.02 APE9-dihe-na -107.63, 178.58 APE8-dihe-out -103.64, -13.88 APE8-rot-out 56.98 APE67-dihe-out -152.18, 145.48 -132.34, 175.09 APE12-dist-out 18.633 APE11-dist-out 16.0857 APE10-dist-out 21.091 APE9-dist-out 12.7711 S218A,S222A None None XRAY 2.07 0.215 0.248 A 310.0 298.0 0 26 26 0 [[68, 361]] 1.0 9axx STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9AXXC Q02750 37 378 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.0661 14.2508 BLBplus -153.34, 165.37 62.85, 41.08 -93.54, 164.6 44.67, 86.41 -75.31, 71.49 out-out out 15.5167 Saltbr-out 15.0221 HRD-in -80.68, -38.87 53.15, 7.3 out-out-out SNCooo out-out ActLoopNT-out 9.6912 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -68.91, 127.09 APE9-dihe-na -100.27, 169.31 APE8-dihe-out -98.12, -23.61 APE8-rot-out 61.42 APE67-dihe-out -153.77, 146.66 -125.41, 178.29 APE12-dist-out 18.4501 APE11-dist-out 16.1193 APE10-dist-out 21.5812 APE9-dist-out 12.7488 S218A,S222A None None XRAY 2.07 0.215 0.248 C 310.0 297.0 1 26 26 0 [[68, 361]] 1.0 9axx STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9AYAB Q02750 42 382 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.2091 14.117 BLBplus -156.4, 169.03 57.59, 47.08 -100.39, 159.82 46.95, 83.0 -73.48, 80.99 out-out out 15.4442 Saltbr-out 14.9574 HRD-in -72.22, -50.64 78.5, -7.92 out-out-out SNCooo out-out ActLoopNT-out 9.725 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -67.32, 133.53 APE9-dihe-na -94.07, -169.54 APE8-dihe-out -110.54, -56.8 APE8-rot-out 71.18 APE67-dihe-out -155.6, 139.89 -98.61, 175.74 APE12-dist-out 17.2211 APE11-dist-out 22.1488 APE10-dist-out 24.1945 APE9-dist-out 13.7662 S218A,S222A None None XRAY 2.59 0.214 0.257 B 310.0 297.0 0 26 26 0 [[68, 361]] 1.0 9aya STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9AYAD Q02750 39 382 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.236 14.1136 BLBplus -150.42, 169.48 62.14, 35.37 -84.74, 166.85 39.42, 88.37 -83.08, 73.44 out-out out 15.3824 Saltbr-out 15.2874 HRD-in -84.82, -56.5 86.5, -11.08 out-out-out SNCooo out-out ActLoopNT-out 9.653 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.69 APE8-dihe-out -103.38, -24.48 APE8-rot-out 47.89 APE67-dihe-out -161.23, 135.82 -100.94, -174.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.7487 S218A,S222A None None XRAY 2.59 0.214 0.257 D 310.0 293.0 7 26 23 3 [[68, 361]] 1.0 9aya STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9AY7B Q02750 33 383 393.0 A1AHE:401,ANP:402 Type1,ATPlike Inactive DFGin 6.1312 14.2675 BLBplus -154.96, 169.08 61.0, 36.72 -91.6, 162.02 49.73, 81.71 -77.61, 77.19 out-out out 15.5132 Saltbr-out 15.4022 HRD-in -75.89, -55.94 83.29, -11.88 out-out-out SNCooo out-out ActLoopNT-out 9.5756 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -66.62, 136.57 APE9-dihe-na -89.93, -175.43 APE8-dihe-out -113.57, -10.62 APE8-rot-out 51.26 APE67-dihe-out -146.5, 144.85 -157.42, 170.13 APE12-dist-out 17.3436 APE11-dist-out 22.1142 APE10-dist-out 24.2068 APE9-dist-out 13.7295 S218A,S222A None None XRAY 2.41 0.203 0.236 B 394.0 322.0 29 26 26 0 [[68, 361]] 1.0 9ay7 STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9O0UH Q02750 30 380 393.0 CHU:401,ANP:402 Type1,ATPlike Inactive DFGin 6.2263 14.2396 BLBplus -153.68, 170.44 61.41, 47.24 -102.95, 164.39 45.69, 94.01 -79.55, 83.41 out-out out 15.5809 Saltbr-out 15.7853 HRD-in -74.86, -48.68 73.9, -6.25 out-out-out SNCooo out-out ActLoopNT-out 9.583 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -141.84, 152.52 APE9-dihe-na -130.16, 177.33 APE8-dihe-out -105.34, -25.09 APE8-rot-out 37.73 APE67-dihe-out -147.39, 136.35 -136.55, 176.51 APE12-dist-out 17.387 APE11-dist-out 17.659 APE10-dist-out 22.2151 APE9-dist-out 12.9967 S218A,S222A None None XRAY 2.91 0.232 0.264 H 395.0 315.0 36 26 26 0 [[68, 361]] 1.0 9o0u STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9O0VB Q02750 30 380 393.0 CHU:401,ANP:402 Type1,ATPlike Inactive DFGin 6.1927 14.1253 BLBplus -151.85, 167.5 59.4, 48.24 -102.03, 163.4 46.52, 86.88 -79.89, 84.21 out-out out 15.5955 Saltbr-out 16.8415 HRD-in -72.2, -48.2 74.46, -6.51 out-out-out SNCooo out-out ActLoopNT-out 9.7061 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -135.59, 156.7 APE9-dihe-na -122.67, 146.4 APE8-dihe-out -101.77, -26.6 APE8-rot-in 280.72 APE67-dihe-out -147.98, 135.29 -136.69, 175.09 APE12-dist-out 16.923 APE11-dist-out 17.129 APE10-dist-out 21.8624 APE9-dist-out 12.4292 S218A,S222A None None XRAY 3.5 0.208 0.254 B 395.0 322.0 29 26 26 0 [[68, 361]] 1.0 9o0v STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9O0VH Q02750 30 380 393.0 CHU:401,ANP:402 Type1,ATPlike Inactive DFGin 6.3491 14.2266 BLBplus -152.81, 169.25 61.22, 47.15 -103.13, 164.19 45.91, 94.17 -79.63, 83.31 out-out out 15.6315 Saltbr-out 15.9163 HRD-in -74.73, -48.72 73.54, -6.07 out-out-out SNCooo out-out ActLoopNT-out 9.5069 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -142.21, 151.98 APE9-dihe-na -130.61, 176.34 APE8-dihe-out -105.52, -25.24 APE8-rot-out 37.89 APE67-dihe-out -147.93, 136.16 -136.73, 176.12 APE12-dist-out 17.2775 APE11-dist-out 17.5835 APE10-dist-out 22.1521 APE9-dist-out 13.0006 S218A,S222A None None XRAY 3.5 0.208 0.254 H 395.0 318.0 33 26 26 0 [[68, 361]] 1.0 9o0v STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7XLPA Q02750 37 382 393.0 FZC:401 Type1.5_Back Inactive DFGin 6.2224 13.8185 BLBplus -149.23, 171.7 63.72, 39.53 -97.73, 126.21 51.37, 93.64 -69.1, 142.41 out-out out 15.2739 Saltbr-out 13.8233 HRD-in -68.97, -49.54 73.5, 1.6 out-out-out SNCooo out-out ActLoopNT-out 10.5524 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 129.04 APE8-dihe-in -69.42, 147.01 APE8-rot-out 179.16 APE67-dihe-in -70.91, -10.2 -108.37, 12.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.4117 S298N,S299K,Y300K None None XRAY 2.1 0.22 0.246 A 348.0 312.0 34 26 22 4 [[68, 361]] 1.0 7xlp STE_MAP2K1_HUMAN STE 1.6e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7MFDB Q02750 52 383 393.0 CHU:401 Type3 Inactive DFGin 5.404 15.0019 BLBplus -158.62, 167.12 60.92, 63.61 -97.12, -175.46 63.42, 90.2 -85.78, 95.16 out-out out 16.3227 Saltbr-out 15.7256 HRD-in -63.97, -52.79 67.43, -4.72 out-out-out SNCooo out-out ActLoopNT-out 9.6757 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -74.44, -63.74 APE9-dihe-na 63.29, 177.26 APE8-dihe-out -134.0, -13.26 APE8-rot-out 186.3 APE67-dihe-out -128.3, 117.83 -113.33, 134.88 APE12-dist-out 15.8757 APE11-dist-out 14.2111 APE10-dist-out 20.3493 APE9-dist-out 12.7512 None None None EM 3.66 999.0 999.0 B 393.0 293.0 39 26 26 0 [[68, 361]] 1.0 7mfd STE_MAP2K1_HUMAN STE 2.4e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9O2ZB Q02750 52 383 393.0 CHU:401 Type3 Inactive DFGin 5.6928 14.5575 BLBplus -161.53, 165.82 61.62, 61.08 -96.61, -171.26 43.54, 100.17 -85.43, 98.09 out-out out 16.5961 Saltbr-out 16.4609 HRD-in -72.32, -46.17 67.98, -6.22 out-out-out SNCooo out-out ActLoopNT-out 9.6467 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -91.74, -52.46 APE9-dihe-na 52.82, -171.67 APE8-dihe-out -137.35, -7.44 APE8-rot-out 199.8 APE67-dihe-out -140.63, 115.25 -121.25, 136.62 APE12-dist-out 16.3961 APE11-dist-out 14.2482 APE10-dist-out 20.3544 APE9-dist-out 13.1205 None None None EM 3.83 999.0 999.0 B 393.0 293.0 39 26 26 0 [[68, 361]] 1.0 9o2z STE_MAP2K1_HUMAN STE 2.4e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9AXAB Q02750 52 380 393.0 A1AHE:401 Type3 Inactive DFGin 6.8129 13.7682 BLBplus -157.46, 170.37 59.28, 64.98 -117.48, 165.11 40.29, 81.19 -81.1, 74.19 out-out out 15.4311 Saltbr-out 17.4099 HRD-in -75.24, -42.64 72.38, -11.77 out-out-out SNCooo out-out ActLoopNT-out 9.2081 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -68.37, -62.71 APE9-dihe-na 103.09, 102.94 APE8-dihe-out -88.38, -48.33 APE8-rot-out 62.02 APE67-dihe-out -122.1, 131.17 -98.78, 143.35 APE12-dist-out 16.6961 APE11-dist-out 18.1264 APE10-dist-out 22.8521 APE9-dist-out 12.4243 S218A,S222A None None EM 4.36 999.0 999.0 B 394.0 278.0 51 26 26 0 [[68, 361]] 1.0 9axa STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9AXAD Q02750 59 383 393.0 A1AHE:401 Type3 Inactive DFGin 6.1878 15.038 BLBplus -161.59, 167.64 63.71, 27.36 -77.56, 162.55 63.45, 90.49 -80.72, 76.54 out-out out 17.6128 Saltbr-out 18.7979 HRD-in -103.62, -49.66 71.76, -9.27 out-out-out SNCooo out-out ActLoopNT-out 9.7971 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na 56.39, -81.94 APE9-dihe-na 48.87, 69.85 APE8-dihe-out -71.23, -18.7 APE8-rot-out 181.91 APE67-dihe-out -127.48, 156.86 -129.99, 139.21 APE12-dist-out 19.1615 APE11-dist-out 16.676 APE10-dist-out 21.3744 APE9-dist-out 12.2717 S218A,S222A None None EM 4.36 999.0 999.0 D 394.0 275.0 50 26 26 0 [[68, 361]] 1.0 9axa STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9AXCB Q02750 52 380 393.0 A1AHE:401 Type3 Inactive DFGin 5.9787 13.8572 BLBplus -156.34, 159.86 58.05, 51.28 -90.68, 168.57 45.43, 79.18 -80.79, 77.37 out-out out 15.5246 Saltbr-out 16.4826 HRD-in -82.47, -42.11 70.94, -10.4 out-out-out SNCooo out-out ActLoopNT-out 9.4447 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -71.13, -44.57 APE9-dihe-na 100.23, 100.79 APE8-dihe-out -96.55, -49.37 APE8-rot-out 61.77 APE67-dihe-out -125.36, 134.49 -112.13, 139.3 APE12-dist-out 16.7317 APE11-dist-out 18.0625 APE10-dist-out 22.9269 APE9-dist-out 12.6232 S218A,S222A None None EM 4.16 999.0 999.0 B 394.0 278.0 51 26 26 0 [[68, 361]] 1.0 9axc STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9AXCD Q02750 59 383 393.0 A1AHE:401 Type3 Inactive DFGin 5.9443 14.9428 BLBplus -155.71, -173.77 60.85, 40.35 -100.84, 165.38 63.0, 90.55 -83.19, 80.54 out-out out 17.464 Saltbr-out 19.8823 HRD-in -94.68, -47.55 72.62, -11.59 out-out-out SNCooo out-out ActLoopNT-out 9.3746 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na 51.94, -88.31 APE9-dihe-na 51.11, 70.23 APE8-dihe-out -66.0, -35.69 APE8-rot-in 292.49 APE67-dihe-out -158.48, 126.03 -105.47, -179.54 APE12-dist-out 18.7745 APE11-dist-out 17.0622 APE10-dist-out 21.141 APE9-dist-out 12.4403 S218A,S222A None None EM 4.16 999.0 999.0 D 394.0 275.0 50 26 26 0 [[68, 361]] 1.0 9axc STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9O0UD Q02750 31 380 393.0 CHU:401 Type3 Inactive DFGin 6.2577 14.2452 BLBplus -155.2, 170.07 62.24, 48.49 -103.46, 163.38 44.86, 81.23 -80.64, 82.9 out-out out 15.8042 Saltbr-out 15.5601 HRD-in -72.61, -47.48 72.0, -5.51 out-out-out SNCooo out-out ActLoopNT-out 9.507 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -145.99, 151.57 APE9-dihe-na -129.02, 151.01 APE8-dihe-out -101.49, -25.69 APE8-rot-in 295.14 APE67-dihe-out -149.54, 133.77 -134.81, 174.59 APE12-dist-out 17.407 APE11-dist-out 17.5585 APE10-dist-out 22.6481 APE9-dist-out 12.7538 S218A,S222A None None XRAY 2.91 0.232 0.264 D 395.0 317.0 33 26 26 0 [[68, 361]] 1.0 9o0u STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9O0UF Q02750 30 380 393.0 CHU:401 Type3 Inactive DFGin 6.24 14.2415 BLBplus -149.4, 162.55 67.26, 47.9 -103.2, 163.92 46.52, 88.85 -79.29, 85.22 out-out out 15.5394 Saltbr-out 16.2358 HRD-in -74.73, -46.69 72.92, -6.37 out-out-out SNCooo out-out ActLoopNT-out 9.8344 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -124.83, 125.43 APE9-dihe-na -156.49, 116.77 APE8-dihe-out -98.23, -8.63 APE8-rot-in 320.21 APE67-dihe-out -147.81, 133.84 -133.15, 172.65 APE12-dist-out 18.6641 APE11-dist-out 16.7859 APE10-dist-out 21.1732 APE9-dist-out 12.5375 S218A,S222A None None XRAY 2.91 0.232 0.264 F 395.0 322.0 29 26 26 0 [[68, 361]] 1.0 9o0u STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 4AN2A Q02750 61 381 393.0 EUI:61382,ACP:61383 Type3,ATPlike Inactive DFGin 6.5059 13.6203 BLBplus -122.79, 178.99 56.84, 40.15 -92.39, 167.6 39.23, 93.66 -89.21, 72.99 out-out out 15.4473 Saltbr-out 15.2762 HRD-in -67.56, -54.42 79.08, -11.1 out-out-out SNCooo out-out ActLoopNT-out 9.0354 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -98.27, 63.09 APE9-dihe-na -45.72, -71.67 APE8-dihe-in -89.8, 67.42 APE8-rot-out 5.41 APE67-dihe-in -66.45, -14.82 -49.39, -42.64 APE12-dist-out 17.4744 APE11-dist-out 16.5588 APE10-dist-out 17.0301 APE9-dist-out 8.7163 S218E,S222E,G328A None None XRAY 2.5 0.215 0.299 A 301.0 279.0 0 26 26 0 [[68, 361]] 1.0 4an2 STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 4ANBA Q02750 61 381 393.0 YQY:60501,ACP:60502 Type3,ATPlike Inactive DFGin 6.3584 13.3927 BLBplus -107.54, 172.13 64.32, 39.17 -93.81, 160.33 38.34, 94.07 -83.38, 74.0 out-out out 15.2238 Saltbr-out 14.8172 HRD-in -75.33, -47.65 77.84, -16.31 out-out-out SNCooo out-out ActLoopNT-out 9.4144 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -89.14, -39.83 APE9-dihe-na 89.67, -158.68 APE8-dihe-in -87.88, 72.09 APE8-rot-out 15.75 APE67-dihe-in -64.72, -18.82 -69.34, -22.58 APE12-dist-out 17.552 APE11-dist-out 16.8932 APE10-dist-out 19.8413 APE9-dist-out 8.65 S218E,S222E,G328A None None XRAY 2.2 0.23 0.296 A 301.0 279.0 0 26 26 0 [[68, 361]] 1.0 4anb STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 2P55A Q02750 62 382 393.0 MRA:69000,ATP:69001 Type3,ATPlike Inactive DFGin 6.1626 13.3824 BLBplus -134.23, -173.95 50.87, 43.67 -95.4, 166.24 42.0, 89.87 -87.86, 76.42 out-out out 15.2177 Saltbr-out 15.3456 HRD-in -70.81, -55.41 89.6, -22.02 out-out-out SNCooo out-out ActLoopNT-out 9.468 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -78.03 APE9-dihe-na 94.66, -135.55 APE8-dihe-out -131.47, -8.61 APE8-rot-out 200.5 APE67-dihe-out -121.47, 132.61 -102.76, 124.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.1744 APE9-dist-out 13.9789 None None None XRAY 2.8 0.228 0.301 A 333.0 288.0 33 26 23 3 [[68, 361]] 1.0 2p55 STE_MAP2K1_HUMAN STE 1.4e-97 332.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 4U7ZA Q02750 62 382 393.0 3EW:60502,ANP:60503 Type3,ATPlike Inactive DFGin 6.2159 13.6689 BLBplus -143.34, -175.79 52.44, 38.8 -93.27, 161.31 44.21, 87.69 -81.82, 73.69 out-out out 15.3339 Saltbr-out 16.1402 HRD-in -66.47, -61.07 88.23, -17.21 out-out-out SNCooo out-out ActLoopNT-out 9.1989 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_onoo APE10-dihe-na 999.0, -56.79 APE9-dihe-na 112.87, -133.38 APE8-dihe-out -132.3, 18.52 APE8-rot-out 53.52 APE67-dihe-out -108.34, 133.35 -145.71, 114.06 APE12-dist-out 17.9335 APE11-dist-none 999.0 APE10-dist-out 19.6013 APE9-dist-out 13.9529 None None None XRAY 2.805 0.163 0.214 A 341.0 290.0 31 26 25 1 [[68, 361]] 1.0 4u7z STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 4U81A Q02750 62 382 393.0 3EY:60502,ANP:60503 Type3,ATPlike Inactive DFGin 6.3677 13.5745 BLBplus -142.15, -179.17 57.69, 35.98 -93.9, 164.88 44.15, 86.95 -87.34, 72.9 out-out out 15.2755 Saltbr-out 15.4161 HRD-in -63.27, -55.06 80.23, -11.72 out-out-out SNCooo out-out ActLoopNT-out 9.3239 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -28.47 APE9-dihe-na 110.81, -177.13 APE8-dihe-out -114.66, 19.88 APE8-rot-out 189.5 APE67-dihe-out -109.38, 142.31 -159.49, 131.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.6841 APE9-dist-out 12.9691 None None None XRAY 2.701 0.169 0.218 A 341.0 288.0 33 26 23 3 [[68, 361]] 1.0 4u81 STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3V01A Q02750 62 382 393.0 3V0:60501,ATP:60502 Type3,ATPlike Inactive DFGin 6.105 13.4244 BLBplus -142.06, -173.42 54.59, 34.91 -91.82, 163.8 47.01, 90.27 -88.09, 75.03 out-out out 15.5642 Saltbr-out 15.7785 HRD-in -62.64, -63.68 88.6, -7.02 out-out-out SNCooo out-out ActLoopNT-out 9.2768 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -67.65 APE9-dihe-na 102.3, -166.23 APE8-dihe-out -116.29, 3.8 APE8-rot-out 189.24 APE67-dihe-out -108.4, 130.42 -142.07, 120.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.0771 APE9-dist-out 12.8379 None None None XRAY 2.705 0.189 0.24 A 341.0 288.0 33 26 23 3 [[68, 361]] 1.0 3v01 STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3V04A Q02750 62 382 393.0 V04:60501,ATP:60502 Type3,ATPlike Inactive DFGin 6.2019 13.4656 BLBplus -139.99, -177.53 54.26, 36.29 -92.6, 163.3 43.17, 90.4 -92.7, 75.2 out-out out 15.6131 Saltbr-out 16.0488 HRD-in -56.82, -58.2 81.63, -6.31 out-out-out SNCooo out-out ActLoopNT-out 9.1096 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -43.92 APE9-dihe-na 143.86, 160.52 APE8-dihe-out -85.24, -10.44 APE8-rot-out 182.43 APE67-dihe-out -103.47, 130.39 -134.15, 117.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.8085 APE9-dist-out 12.649 None None None XRAY 2.7 0.213 0.243 A 341.0 288.0 33 26 23 3 [[68, 361]] 1.0 3v04 STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3EQCA Q02750 39 382 393.0 3BM:1,AGS:2 Type3,ATPlike Inactive DFGin 6.1057 13.8617 BLBplus -138.12, -177.12 54.65, 30.92 -83.74, 156.51 44.84, 87.16 -79.52, 70.22 out-out out 15.3111 Saltbr-out 14.7046 HRD-in -64.92, -56.9 85.6, -17.06 out-out-out SNCooo out-out ActLoopNT-out 9.3671 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 106.4 APE9-dihe-na -87.03, 145.5 APE8-dihe-in -52.92, 140.89 APE8-rot-out 198.88 APE67-dihe-in -66.8, -13.13 -101.4, 5.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.4624 APE9-dist-out 9.4427 S298N,S299K,Y300F None None XRAY 1.8 0.201 0.235 A 360.0 312.0 32 26 23 3 [[68, 361]] 1.0 3eqc STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3EQHA Q02750 39 381 393.0 5BM:1,ADP:2 Type3,ATPlike Inactive DFGin 6.8455 13.3483 BLBplus -141.56, 168.5 59.76, 36.07 -79.95, 154.58 28.74, 98.71 -78.77, 88.92 out-out out 15.2501 Saltbr-out 13.9257 HRD-in -70.86, -51.49 82.66, -16.34 out-out-out SNCooo out-out ActLoopNT-out 9.8448 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na 72.18, 69.91 APE9-dihe-na -156.93, 105.03 APE8-dihe-in -35.31, 137.66 APE8-rot-out 209.36 APE67-dihe-in -58.22, -17.3 -105.41, 1.3 APE12-dist-out 17.8887 APE11-dist-out 18.0239 APE10-dist-out 19.2755 APE9-dist-out 9.6547 S298N,S299K,Y300F None None XRAY 2.0 0.192 999.0 A 360.0 314.0 29 26 26 0 [[68, 361]] 1.0 3eqh STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9ECUB Q02750 43 383 393.0 A1BIS:401,ANP:402 Type3,ATPlike Inactive DFGin 5.9391 13.7784 BLBplus -142.06, 162.17 53.85, 47.21 -95.43, 152.31 51.94, 84.92 -79.97, 96.68 out-out out 15.5116 Saltbr-out 16.1296 HRD-in -66.75, -57.05 86.44, -9.92 out-out-out SNCooo out-out ActLoopNT-out 9.377 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -121.25, 157.88 APE9-dihe-na -135.0, 168.26 APE8-dihe-out -68.75, -42.35 APE8-rot-in 291.8 APE67-dihe-out -146.65, 140.6 -150.67, 174.43 APE12-dist-out 21.121 APE11-dist-out 17.8937 APE10-dist-out 23.1346 APE9-dist-out 13.6562 None None None XRAY 3.46 0.202 0.237 B 393.0 309.0 32 26 26 0 [[68, 361]] 1.0 9ecu STE_MAP2K1_HUMAN STE 2.4e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9AXYB Q02750 40 383 393.0 A1AHE:401,ANP:402 Type3,ATPlike Inactive DFGin 5.9383 14.1345 BLBplus -149.11, 165.49 51.9, 40.29 -92.3, 159.5 54.58, 76.32 -75.9, 70.87 out-out out 15.3992 Saltbr-out 14.9875 HRD-in -57.0, -47.47 79.88, -10.87 out-out-out SNCooo out-out ActLoopNT-out 9.3372 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -115.09, 128.49 APE9-dihe-na -79.18, 173.05 APE8-dihe-out -111.11, -19.81 APE8-rot-out 47.95 APE67-dihe-out -148.5, 141.81 -130.51, 175.5 APE12-dist-out 18.1758 APE11-dist-out 19.7311 APE10-dist-out 22.7854 APE9-dist-out 13.2287 S218A,S222A None None XRAY 3.6 0.19 0.237 B 394.0 312.0 32 26 26 0 [[68, 361]] 1.0 9axy STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9O0VD Q02750 31 380 393.0 CHU:401,ANP:402 Type3,ATPlike Inactive DFGin 6.3733 14.325 BLBplus -154.54, 169.16 62.18, 48.49 -103.44, 163.24 44.6, 81.5 -80.27, 83.26 out-out out 16.0835 Saltbr-out 14.6053 HRD-in -72.92, -47.49 72.01, -5.54 out-out-out SNCooo out-out ActLoopNT-out 9.4975 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -145.24, 151.58 APE9-dihe-na -129.14, 150.7 APE8-dihe-out -101.27, -25.48 APE8-rot-in 295.39 APE67-dihe-out -149.5, 133.8 -134.87, 174.51 APE12-dist-out 17.6813 APE11-dist-out 17.5865 APE10-dist-out 22.6132 APE9-dist-out 12.7344 S218A,S222A None None XRAY 3.5 0.208 0.254 D 395.0 315.0 35 26 26 0 [[68, 361]] 1.0 9o0v STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 9O0VF Q02750 30 380 393.0 CHU:401,ANP:402 Type3,ATPlike Inactive DFGin 6.3482 14.2973 BLBplus -150.02, 162.92 66.4, 48.22 -102.89, 163.79 46.62, 89.05 -79.32, 84.9 out-out out 15.5104 Saltbr-out 15.8816 HRD-in -75.24, -46.98 72.8, -6.4 out-out-out SNCooo out-out ActLoopNT-out 9.801 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -127.4, 126.99 APE9-dihe-na -155.92, 117.08 APE8-dihe-out -98.23, -9.95 APE8-rot-in 320.72 APE67-dihe-out -148.49, 134.6 -133.67, 172.28 APE12-dist-out 18.6736 APE11-dist-out 16.7401 APE10-dist-out 21.3436 APE9-dist-out 12.7026 S218A,S222A None None XRAY 3.5 0.208 0.254 F 395.0 322.0 29 26 26 0 [[68, 361]] 1.0 9o0v STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7M0TB Q02750 42 383 393.0 3EW:401,ANP:402 Type3,ATPlike Inactive DFGin 6.0753 13.7095 BLBplus -159.9, -178.5 64.02, 41.63 -104.3, 143.17 46.34, 100.82 -64.54, 70.24 out-out out 15.4777 Saltbr-out 16.3323 HRD-in -53.73, -55.69 69.68, 5.22 out-out-out SNCooo out-out ActLoopNT-out 8.8715 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -40.91, 141.26 APE9-dihe-na -101.18, -177.28 APE8-dihe-out -68.44, -50.32 APE8-rot-in 321.79 APE67-dihe-out -148.38, 132.66 -145.97, 175.15 APE12-dist-out 17.1657 APE11-dist-out 22.6476 APE10-dist-out 23.7095 APE9-dist-out 13.8641 S218A,S222A None None XRAY 3.19 0.199 0.254 B 397.0 310.0 32 26 26 0 [[68, 361]] 1.0 7m0t STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7M0UB Q02750 43 385 393.0 QO7:501,ANP:502 Type3,ATPlike Inactive DFGin 6.1782 13.8403 BLBplus -152.87, -177.82 54.02, 43.66 -96.33, 148.45 42.9, 86.91 -71.94, 82.66 out-out out 15.4928 Saltbr-out 15.6637 HRD-in -60.41, -57.85 71.46, -3.21 out-out-out SNCooo out-out ActLoopNT-out 9.0481 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -60.78, 138.09 APE9-dihe-na -86.76, -175.69 APE8-dihe-out -100.26, -15.57 APE8-rot-out 49.06 APE67-dihe-out -118.78, 147.11 -163.65, 150.46 APE12-dist-out 17.2011 APE11-dist-out 22.3588 APE10-dist-out 23.5662 APE9-dist-out 13.6379 S218A,S222A None None XRAY 3.09 0.193 0.23 B 397.0 311.0 32 26 26 0 [[68, 361]] 1.0 7m0u STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 5YT3B Q02750 40 382 393.0 ANP:401 ATPlike Inactive DFGin 5.8963 14.534 None -102.15, -169.78 -40.15, 149.52 -75.91, 143.56 303.08, 84.8 -64.88, 94.03 out-out out 16.3586 Saltbr-out 14.8656 HRD-out -104.42, 23.77 -144.46, 111.13 out-out-out SNCooo out-out ActLoopNT-out 8.0209 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -80.58, -32.09 APE9-dihe-na -86.11, -15.83 APE8-dihe-out 58.15, 64.44 APE8-rot-in 310.76 APE67-dihe-out -122.56, 143.11 -138.66, 139.98 APE12-dist-out 19.0552 APE11-dist-out 14.0554 APE10-dist-out 18.8403 APE9-dist-out 25.9099 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 B 350.0 311.0 32 26 26 0 [[68, 361]] 1.0 5yt3 STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 5YT3D Q02750 39 382 393.0 ANP:401 ATPlike Inactive DFGin 5.7501 14.7176 None -77.53, 172.31 -71.81, 159.92 -66.82, 141.72 314.31, 87.77 -59.96, 135.61 out-out out 16.8715 Saltbr-out 15.0058 HRD-out -106.97, -11.01 -97.02, 107.72 out-out-out SNCooo out-out ActLoopNT-out 8.2442 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -63.82, -51.0 APE9-dihe-na -70.37, -13.35 APE8-dihe-out 47.35, 74.88 APE8-rot-out 143.99 APE67-dihe-out -134.73, 126.26 -143.64, 140.67 APE12-dist-out 19.3394 APE11-dist-out 14.3822 APE10-dist-out 19.1547 APE9-dist-out 26.1684 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 D 350.0 309.0 35 26 26 0 [[68, 361]] 1.0 5yt3 STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 8YP4A Q02750 34 384 393.0 WNT:401 Type1 Inactive DFGin 5.6499 12.5748 None -114.29, -33.59 -28.46, 108.03 -125.65, 141.38 278.55, 110.59 -62.12, 167.08 out-out out 15.0636 Saltbr-out 17.0816 HRD-out 70.59, -102.97 160.56, -67.88 out-out-out SNCooo out-out ActLoopNT-out 13.7522 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, 77.83 APE9-dihe-na -121.62, 81.96 APE8-dihe-out 101.02, -24.75 APE8-rot-in 322.27 APE67-dihe-out -132.46, 136.61 -111.44, 133.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.1822 APE9-dist-out 15.9962 T286A,T292A,S298A None None XRAY 2.35 0.21 0.284 A 365.0 305.0 46 26 17 9 [[68, 361]] 1.0 8yp4 STE_MAP2K1_HUMAN STE 1.9e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 5YT3A Q02750 39 382 393.0 ANP:401 ATPlike Inactive DFGinter 6.3567 10.3827 None -128.68, 173.26 63.68, 38.66 -52.93, -21.76 28.6, 36.22 -61.84, 114.84 out-out out 16.3153 Saltbr-out 14.589 HRD-in -77.7, -42.23 58.41, 13.61 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 70.97 APE8-rot-none 999.0 APE67-dihe-out -132.4, 139.8 -149.07, 91.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 A 350.0 297.0 47 26 12 14 [[68, 361]] 1.0 5yt3 STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 5HZEA Q02750 43 382 393.0 E62:401 Type1 Inactive DFGout 13.1327 7.9841 None -116.15, 117.25 -152.6, 137.8 -122.31, 13.73 47.76, 105.92 -84.87, 19.19 out-out out 15.2588 Saltbr-out 14.5791 HRD-none 999.0, 999.0 999.0, 171.7 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -139.21, 125.62 APE9-dihe-na -55.02, 151.61 APE8-dihe-in -60.96, 141.55 APE8-rot-out 186.19 APE67-dihe-in -73.9, -3.69 -95.68, 3.3 APE12-dist-out 18.0199 APE11-dist-out 17.7496 APE10-dist-out 16.6379 APE9-dist-out 10.6787 S298N,S299K,Y300F None None XRAY 2.4 0.205 0.287 A 348.0 305.0 35 26 26 0 [[68, 361]] 1.0 5hze STE_MAP2K1_HUMAN STE 1.6e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 8YP4B Q02750 43 383 393.0 WNT:402 Type1 Inactive DFGout 11.3253 6.4247 None -108.9, 111.79 -94.09, -121.26 66.37, 140.13 107.59, 69.46 128.79, 15.36 out-out out 15.3476 Saltbr-out 16.193 HRD-out 49.23, 166.44 96.35, 147.86 out-out-out SNCooo out-out ActLoopNT-out 11.7919 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -125.63 APE8-rot-out 65.35 APE67-dihe-out 121.59, -95.83 78.91, 128.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T286A,T292A,S298A None None XRAY 2.35 0.21 0.284 B 365.0 299.0 42 26 15 11 [[68, 361]] 1.0 8yp4 STE_MAP2K1_HUMAN STE 1.9e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 7F2XA Q02750 45 382 393.0 ANP:60501 ATPlike Inactive None 14.5783 16.4961 None -71.03, 160.3 -74.32, 105.83 -69.14, -7.13 285.96, 1.01 -79.69, -8.9 out-out out 16.3606 Saltbr-out 16.8732 HRD-out -123.25, -2.01 -136.26, 151.99 out-out-out SNCooo out-out ActLoopNT-out 10.3746 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -84.56, -47.24 APE9-dihe-na 151.04, 109.57 APE8-dihe-in -68.48, 129.23 APE8-rot-in 304.12 APE67-dihe-out -103.66, 129.16 -127.47, 104.31 APE12-dist-out 14.4563 APE11-dist-out 17.6728 APE10-dist-out 20.3077 APE9-dist-out 25.5229 None None None XRAY 2.007 0.216 0.232 A 321.0 300.0 0 26 26 0 [[68, 361]] 1.0 7f2x STE_MAP2K1_HUMAN STE 1.4e-97 332.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 3W8QA Q02750 39 382 393.0 AGS:401 ATPlike Inactive None 13.1078 15.1223 None -61.95, 160.72 -84.08, 71.5 -96.94, 162.22 62.16, 97.76 71.69, 28.05 out-out out 16.278 Saltbr-out 14.58 HRD-out -76.9, 112.47 -115.43, 103.34 out-out-out SNCooo out-out ActLoopNT-out 11.4785 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -85.42, 139.56 APE9-dihe-na 64.92, 170.12 APE8-dihe-in -109.26, 128.33 APE8-rot-out 42.71 APE67-dihe-out -157.09, 132.41 -146.54, 166.67 APE12-dist-out 15.6567 APE11-dist-out 20.9119 APE10-dist-out 24.1063 APE9-dist-out 32.1107 T292A,S298A None None XRAY 2.2 0.201 0.268 A 350.0 318.0 26 26 26 0 [[68, 361]] 1.0 3w8q STE_MAP2K1_HUMAN STE 1.6e-97 331.8 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 6Q0TC Q02750 43 379 393.0 LCJ:60402,AGS:60403 Type1,ATPlike Inactive None 999.0 999.0 None -140.61, 176.69 54.64, 28.33 -81.67, 161.61 999.0, 999.0 -81.74, 73.01 out-none out 15.4983 Saltbr-none 999.0 HRD-in -63.91, -56.51 90.24, -35.06 none-out-out SNCnoo out-out ActLoopNT-out 9.2901 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oooo APE10-dihe-na -73.68, 137.65 APE9-dihe-na -84.71, 179.02 APE8-dihe-out -112.93, -24.43 APE8-rot-none 999.0 APE67-dihe-out -153.47, 146.62 -142.35, -172.44 APE12-dist-out 17.1555 APE11-dist-out 21.6524 APE10-dist-out 23.7974 APE9-dist-out 13.4988 S218A,S222A None None EM 5.7 999.0 999.0 C 414.0 306.0 31 26 26 0 [[68, 361]] 1.0 6q0t STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 6Q0JC Q02750 43 379 393.0 LCJ:60402,AGS:60403 Type1,ATPlike Inactive None 999.0 999.0 None -140.59, 176.71 54.64, 28.27 -81.59, 161.59 999.0, 999.0 -81.72, 72.97 out-none out 15.4979 Saltbr-none 999.0 HRD-in -63.96, -56.51 90.23, -35.02 none-out-out SNCnoo out-out ActLoopNT-out 9.2895 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oooo APE10-dihe-na -73.68, 137.68 APE9-dihe-na -84.7, 179.01 APE8-dihe-out -112.95, -24.41 APE8-rot-none 999.0 APE67-dihe-out -153.48, 146.63 -142.35, -172.44 APE12-dist-out 17.1558 APE11-dist-out 21.6526 APE10-dist-out 23.7977 APE9-dist-out 13.4984 S218A,S222A None None EM 4.9 999.0 999.0 C 415.0 306.0 31 26 26 0 [[68, 361]] 1.0 6q0j STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 6Q0JD Q02750 43 379 393.0 LCJ:60402,AGS:60403 Type1,ATPlike Inactive None 999.0 999.0 None -140.57, 176.69 54.62, 28.33 -81.6, 161.59 999.0, 999.0 -81.66, 72.9 out-none out 15.4977 Saltbr-none 999.0 HRD-in -63.9, -56.54 90.23, -35.02 none-out-out SNCnoo out-out ActLoopNT-out 9.2893 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oooo APE10-dihe-na -73.75, 137.67 APE9-dihe-na -84.68, 179.02 APE8-dihe-out -112.95, -24.44 APE8-rot-none 999.0 APE67-dihe-out -153.47, 146.64 -142.36, -172.48 APE12-dist-out 17.1558 APE11-dist-out 21.6536 APE10-dist-out 23.7977 APE9-dist-out 13.4991 S218A,S222A None None EM 4.9 999.0 999.0 D 415.0 306.0 31 26 26 0 [[68, 361]] 1.0 6q0j STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1

STE_MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)

Total number of chains: 129
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 114 88.4% 9AXXA
None None 5 3.9% 7F2XA
DFGin None 3 2.3% 5YT3B
DFGin BLAminus 2 1.6% AF-Q02750-K1A
DFGin BLBminus 2 1.6% 8CHFE
DFGout None 2 1.6% 5HZEA
DFGinter None 1 0.8% 5YT3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP2K1 MP2K1_HUMAN AF-Q02750-K1A Q02750 60 369 393.0 No_ligand No_ligand Active DFGin 6.7617 13.9206 BLAminus -141.48, 178.33 62.51, 67.83 -84.66, 11.29 303.49, 105.97 -58.9, -35.51 in-in in 8.7469 Saltbr-in 2.7808 HRD-in -71.48, -46.02 68.89, 6.27 in-in-in SNCiii in-in ActLoopNT-in 3.1613 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.25, 157.79 APE9-dihe-na 87.59, -179.27 APE8-dihe-in -77.79, 114.77 APE8-rot-in 310.06 APE67-dihe-in -64.37, -36.32 -49.36, -36.23 APE12-dist-in 9.1608 APE11-dist-in 11.0784 APE10-dist-in 5.1468 APE9-dist-in 3.6476 None None None AF2 -1.0 1.0 1.0 A 310.0 310.0 0 26 26 0 [[68, 361]] 1.0 AF-Q02750-K1 Homo sapiens STE_MAP2K1_HUMAN STE 1e-97 332.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN AF-Q02750-K3A Q02750 60 369 393.0 No_ligand No_ligand Active DFGin 6.5567 14.3808 BLAminus -143.24, 178.57 58.61, 67.22 -80.37, 9.59 297.91, 96.18 -56.08, -30.18 in-in in 8.7799 Saltbr-in 2.7216 HRD-in -72.62, -42.76 70.59, -5.92 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.2, 127.08 APE9-dihe-na 138.9, -176.14 APE8-dihe-in -75.17, 114.71 APE8-rot-in 307.94 APE67-dihe-in -66.43, -20.65 -55.45, -37.06 APE12-dist-in 8.962 APE11-dist-in 11.3261 APE10-dist-in 5.4896 APE9-dist-in 3.9396 None None None AF2 -1.0 1.0 1.0 A 310.0 310.0 0 26 26 0 [[68, 361]] 1.0 AF-Q02750-K3 Homo sapiens STE_MAP2K1_HUMAN STE 1e-97 332.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 8CHFE Q02750 62 379 393.0 No_ligand No_ligand Inactive DFGin 8.7484 15.2997 BLBminus -137.77, -175.22 48.59, 66.74 -80.75, 172.08 303.75, 164.33 -88.09, 43.03 out-out out 15.1413 Saltbr-out 14.1559 HRD-in -63.69, -43.07 70.86, -8.01 out-out-out SNCooo out-out ActLoopNT-out 9.061 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -100.97, 134.92 APE9-dihe-na -78.84, 122.16 APE8-dihe-out -62.21, -40.86 APE8-rot-out 69.52 APE67-dihe-out -84.12, 93.44 -141.68, 94.92 APE12-dist-out 16.2177 APE11-dist-out 19.9204 APE10-dist-out 22.4925 APE9-dist-out 12.4155 S218A,S222A None None EM 4.25 0.445 999.0 E 393.0 278.0 40 26 26 0 [[68, 361]] 1.0 8chf Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 8CHFF Q02750 62 379 393.0 No_ligand No_ligand Inactive DFGin 8.7485 15.2989 BLBminus -137.78, -175.27 48.68, 66.76 -80.77, 172.08 303.82, 164.27 -88.11, 43.03 out-out out 15.1413 Saltbr-out 14.1562 HRD-in -63.7, -43.05 70.8, -7.98 out-out-out SNCooo out-out ActLoopNT-out 9.0612 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -100.94, 134.91 APE9-dihe-na -78.8, 122.14 APE8-dihe-out -62.21, -40.91 APE8-rot-out 69.52 APE67-dihe-out -84.11, 93.44 -141.62, 94.91 APE12-dist-out 16.2176 APE11-dist-out 19.9205 APE10-dist-out 22.4925 APE9-dist-out 12.4151 S218A,S222A None None EM 4.25 0.445 999.0 F 393.0 278.0 40 26 26 0 [[68, 361]] 1.0 8chf Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3EQDA Q02750 39 382 393.0 AGS:2 ATPlike Inactive DFGin 5.9616 14.1078 BLBplus -148.22, 169.15 61.13, 42.77 -94.74, 116.91 42.1, 90.93 -43.97, 123.65 out-out out 15.0819 Saltbr-out 14.8735 HRD-in -61.74, -59.42 83.27, -18.79 out-out-out SNCooo out-out ActLoopNT-out 10.9097 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -139.36, 111.64 APE9-dihe-na -74.03, 166.79 APE8-dihe-in -61.05, 144.18 APE8-rot-out 194.8 APE67-dihe-in -63.95, -10.98 -107.09, 3.75 APE12-dist-out 19.9512 APE11-dist-out 15.017 APE10-dist-out 16.7322 APE9-dist-out 9.444 S298N,S299K,Y300F None None XRAY 2.1 0.211 999.0 A 360.0 315.0 29 26 26 0 [[68, 361]] 1.0 3eqd Homo sapiens STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3EQIA Q02750 39 382 393.0 ADP:2 ATPlike Inactive DFGin 6.097 14.1456 BLBplus -145.58, 171.19 59.48, 41.15 -92.75, 128.75 41.67, 88.89 -58.7, 127.06 out-out out 15.2136 Saltbr-out 14.7281 HRD-in -57.14, -59.8 81.96, -12.14 out-out-out SNCooo out-out ActLoopNT-out 10.7022 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -160.04, 114.16 APE9-dihe-na -79.94, 159.35 APE8-dihe-in -52.77, 143.91 APE8-rot-out 201.8 APE67-dihe-in -60.21, -14.42 -106.05, 1.41 APE12-dist-out 20.1478 APE11-dist-out 15.2393 APE10-dist-out 17.2957 APE9-dist-out 9.228 S298N,S299K,Y300F None None XRAY 1.9 0.165 999.0 A 360.0 315.0 29 26 26 0 [[68, 361]] 1.0 3eqi Homo sapiens STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 5YT3C Q02750 40 382 393.0 ANP:401 ATPlike Inactive DFGin 5.7908 13.7388 BLBplus -158.87, 169.48 60.29, 28.47 -79.68, 102.42 54.67, 117.74 -64.84, 999.0 out-none out 15.4948 Saltbr-none 999.0 HRD-in -68.06, -45.57 70.46, -13.87 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 133.64 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 C 350.0 288.0 55 26 9 17 [[68, 361]] 1.0 5yt3 Homo sapiens STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 6U2GA Q02750 43 383 393.0 ACP:901 ATPlike Inactive DFGin 5.8079 13.8406 BLBplus -143.7, 174.8 53.7, 47.78 -98.62, 156.52 46.78, 97.62 -76.59, 70.13 out-out out 15.3736 Saltbr-out 14.8686 HRD-in -83.28, -55.76 76.37, -10.26 out-out-out SNCooo out-out ActLoopNT-out 9.207 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -64.24, 146.48 APE9-dihe-na -101.23, -173.03 APE8-dihe-out -114.34, -9.62 APE8-rot-out 55.71 APE67-dihe-out -148.86, 141.69 -149.81, 176.75 APE12-dist-out 19.1865 APE11-dist-out 17.9815 APE10-dist-out 22.1053 APE9-dist-out 12.9996 None None None XRAY 2.886 0.231 0.276 A 394.0 309.0 32 26 26 0 [[68, 361]] 1.0 6u2g Homo sapiens STE_MAP2K1_HUMAN STE 2.4e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 6V2WB Q02750 40 383 393.0 ANP:801 ATPlike Inactive DFGin 5.8394 13.8006 BLBplus -157.59, 169.08 49.06, 44.93 -84.24, 160.32 41.65, 89.8 -73.89, 81.99 out-out out 15.4976 Saltbr-out 15.9009 HRD-in -69.45, -57.02 68.3, 7.65 out-out-out SNCooo out-out ActLoopNT-out 8.701 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -54.4, 144.31 APE9-dihe-na -89.17, -161.86 APE8-dihe-out -115.14, -20.62 APE8-rot-out 48.82 APE67-dihe-out -139.36, 135.26 -146.31, 162.2 APE12-dist-out 17.533 APE11-dist-out 22.7363 APE10-dist-out 24.0164 APE9-dist-out 13.6453 S218A,S222A None None XRAY 3.12 0.189 0.237 B 397.0 312.0 32 26 26 0 [[68, 361]] 1.0 6v2w Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 4MNEA Q02750 63 379 393.0 ACP:901,573:903 ATPlike,Type1 Inactive DFGin 6.3821 13.6901 BLBplus -140.61, 176.72 54.72, 28.13 -81.46, 161.59 52.56, 86.0 -81.78, 73.09 out-out out 15.4969 Saltbr-out 15.7793 HRD-in -64.01, -56.53 90.31, -35.13 out-out-out SNCooo out-out ActLoopNT-out 9.2902 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -73.66, 137.78 APE9-dihe-na -84.79, 178.97 APE8-dihe-out -113.02, -24.38 APE8-rot-out 49.94 APE67-dihe-out -153.46, 146.56 -142.39, -172.52 APE12-dist-out 17.192 APE11-dist-out 21.6533 APE10-dist-out 23.7976 APE9-dist-out 13.4974 None None None XRAY 2.848 0.186 0.24 A 341.0 286.0 31 26 26 0 [[68, 361]] 1.0 4mne Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 4MNED Q02750 66 382 393.0 ACP:901,573:903 ATPlike,Type1 Inactive DFGin 6.2631 13.8726 BLBplus -124.78, 174.1 56.33, 33.25 -88.39, 154.28 50.46, 89.74 -73.02, 74.09 out-out out 15.5381 Saltbr-out 15.6141 HRD-in -64.9, -49.38 74.62, -12.51 out-out-out SNCooo out-out ActLoopNT-out 9.0432 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -65.65, 150.79 APE9-dihe-na -95.28, -163.25 APE8-dihe-out -122.75, -11.87 APE8-rot-out 68.42 APE67-dihe-out -159.06, 142.59 -161.08, -176.92 APE12-dist-out 17.403 APE11-dist-out 21.784 APE10-dist-out 23.8522 APE9-dist-out 13.6322 None None None XRAY 2.848 0.186 0.24 D 341.0 285.0 32 26 26 0 [[68, 361]] 1.0 4mne Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 8DGSB Q02750 38 383 393.0 AGS:60801,LCJ:60803 ATPlike,Type1 Inactive DFGin 6.249 12.9971 BLBplus -155.73, -179.02 61.68, 27.26 -72.39, 155.67 44.5, 85.53 -87.2, 64.42 out-out out 16.2947 Saltbr-out 16.06 HRD-in -62.57, -46.0 64.99, -4.53 out-out-out SNCooo out-out ActLoopNT-out 8.7094 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -122.25, 153.26 APE9-dihe-na -110.07, 177.24 APE8-dihe-out -99.46, -47.43 APE8-rot-out 69.24 APE67-dihe-out -133.48, 170.62 -132.77, 150.72 APE12-dist-out 17.1114 APE11-dist-out 20.5769 APE10-dist-out 22.9193 APE9-dist-out 13.2707 S218A,S222A None None EM 4.3 999.0 999.0 B 414.0 314.0 32 26 26 0 [[68, 361]] 1.0 8dgs Homo sapiens STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 4AN3A Q02750 61 381 393.0 ATP:61383,5Y0:61384 ATPlike,Type3 Inactive DFGin 6.3723 14.221 BLBplus -129.12, 178.33 68.61, 30.98 -85.55, 168.03 44.05, 86.92 -96.2, 75.38 out-out out 15.6935 Saltbr-out 15.4163 HRD-in -67.68, -62.51 95.67, -17.38 out-out-out SNCooo out-out ActLoopNT-out 9.2297 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_onno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -140.36 APE8-dihe-in -98.61, 79.73 APE8-rot-in 326.73 APE67-dihe-in -67.76, -12.96 -73.18, -22.73 APE12-dist-out 17.69 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.352 S218E,S222E,G328A None None XRAY 2.1 0.229 0.283 A 301.0 277.0 2 26 24 2 [[68, 361]] 1.0 4an3 Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 4AN9A Q02750 61 381 393.0 ACP:61382,2P7:61384 ATPlike,Type3 Inactive DFGin 6.3107 13.7515 BLBplus -147.68, 174.84 72.25, 33.73 -84.91, 163.57 42.25, 107.87 -96.68, 81.85 out-out out 15.6879 Saltbr-out 15.1088 HRD-in -67.38, -51.77 90.36, -23.63 out-out-out SNCooo out-out ActLoopNT-out 9.4167 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_onoo APE10-dihe-na 999.0, 140.8 APE9-dihe-na -91.12, -166.68 APE8-dihe-in -63.03, 65.46 APE8-rot-in 350.49 APE67-dihe-in -61.1, -23.55 -42.53, -42.27 APE12-dist-out 17.6262 APE11-dist-none 999.0 APE10-dist-out 19.7035 APE9-dist-out 7.8575 S218E,S222E,G328A None None XRAY 2.8 0.205 0.313 A 301.0 278.0 1 26 25 1 [[68, 361]] 1.0 4an9 Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3SLSA Q02750 45 383 393.0 ANP:60400,77D:60500 ATPlike,Type3 Inactive DFGin 6.0671 13.8281 BLBplus -140.19, 178.66 54.09, 43.7 -94.25, 127.95 47.57, 97.28 -65.93, 145.27 out-out out 15.7649 Saltbr-out 16.2192 HRD-in -71.97, -60.22 78.51, -3.12 out-out-out SNCooo out-out ActLoopNT-out 8.4367 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nooo APE10-dihe-na -93.38, -0.96 APE9-dihe-na -118.58, -150.08 APE8-dihe-out -118.64, -9.13 APE8-rot-out 48.38 APE67-dihe-out -141.57, 136.87 -142.17, 156.77 APE12-dist-none 999.0 APE11-dist-out 20.7273 APE10-dist-out 20.2954 APE9-dist-out 13.9168 None None None XRAY 2.3 0.21 0.287 A 304.0 288.0 7 26 20 6 [[68, 361]] 1.0 3sls Homo sapiens STE_MAP2K1_HUMAN STE 1.4e-98 335.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3SLSB Q02750 45 383 393.0 ANP:60400,77D:60500 ATPlike,Type3 Inactive DFGin 6.2211 13.8152 BLBplus -143.68, 175.58 56.27, 41.79 -94.32, 130.27 43.79, 91.06 -64.4, 146.65 out-out out 15.8164 Saltbr-out 15.9268 HRD-in -71.99, -58.98 74.88, -1.55 out-out-out SNCooo out-out ActLoopNT-out 7.5058 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nooo APE10-dihe-na -110.34, -17.81 APE9-dihe-na 107.94, -164.16 APE8-dihe-out -114.29, -25.66 APE8-rot-out 168.01 APE67-dihe-out -146.37, 136.37 -123.32, 171.0 APE12-dist-none 999.0 APE11-dist-out 19.1374 APE10-dist-out 21.3033 APE9-dist-out 13.5951 None None None XRAY 2.3 0.21 0.287 B 304.0 290.0 5 26 21 5 [[68, 361]] 1.0 3sls Homo sapiens STE_MAP2K1_HUMAN STE 1.4e-98 335.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7B3MA Q02750 37 382 393.0 ANP:60402,SU5:60403 ATPlike,Type3 Inactive DFGin 6.1258 13.3704 BLBplus -148.65, 168.81 60.69, 38.17 -87.91, 154.07 39.86, 88.52 -71.49, 59.19 out-out out 15.3138 Saltbr-out 14.9939 HRD-in -70.73, -50.42 71.08, -9.53 out-out-out SNCooo out-out ActLoopNT-out 8.9548 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -121.3 APE8-dihe-out -86.65, -7.6 APE8-rot-out 192.68 APE67-dihe-out -130.89, 138.61 -149.99, 133.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.6751 None None None XRAY 2.3 0.22 0.268 A 326.0 297.0 5 26 21 5 [[68, 361]] 1.0 7b3m Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7B3MB Q02750 37 382 393.0 ANP:60402,SU5:60403 ATPlike,Type3 Inactive DFGin 6.095 13.3497 BLBplus -147.84, 168.76 59.95, 38.27 -86.94, 152.02 37.7, 89.9 -70.97, 59.7 out-out out 15.2643 Saltbr-out 14.844 HRD-in -70.51, -50.26 71.48, -11.7 out-out-out SNCooo out-out ActLoopNT-out 8.913 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -133.25 APE8-dihe-out -83.19, -28.76 APE8-rot-in 262.25 APE67-dihe-out -150.63, 137.62 -127.52, 158.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0843 None None None XRAY 2.3 0.22 0.268 B 326.0 298.0 4 26 22 4 [[68, 361]] 1.0 7b3m Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7B7RA Q02750 37 382 393.0 ANP:60401,T1K:60403 ATPlike,Type3 Inactive DFGin 6.1419 13.1685 BLBplus -135.79, 174.07 60.45, 39.3 -91.52, 155.87 43.71, 91.25 -77.25, 65.03 out-out out 15.2989 Saltbr-out 15.4643 HRD-in -68.45, -57.29 78.52, -6.73 out-out-out SNCooo out-out ActLoopNT-out 8.9351 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -104.92 APE8-dihe-out -68.21, -24.42 APE8-rot-out 184.14 APE67-dihe-out -122.45, 137.43 -138.43, 139.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.332 None None None XRAY 1.7 0.195 0.218 A 326.0 297.0 5 26 21 5 [[68, 361]] 1.0 7b7r Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7B7RB Q02750 39 382 393.0 ANP:60401,T1K:60403 ATPlike,Type3 Inactive DFGin 6.0337 13.1313 BLBplus -135.72, 177.16 59.39, 36.14 -85.12, 154.58 37.29, 94.77 -80.68, 71.22 out-out out 15.2953 Saltbr-out 15.3776 HRD-in -70.94, -55.67 77.08, -4.68 out-out-out SNCooo out-out ActLoopNT-out 8.8997 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -49.75 APE8-rot-out 171.35 APE67-dihe-out -144.02, 141.19 -140.4, 157.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.195 0.218 B 326.0 295.0 5 26 21 5 [[68, 361]] 1.0 7b7r Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7B94A Q02750 37 382 393.0 ANP:60401,T3W:60403 ATPlike,Type3 Inactive DFGin 5.9919 13.4781 BLBplus -132.63, 177.07 57.77, 37.37 -87.97, 156.39 42.38, 94.42 -75.9, 68.49 out-out out 15.5318 Saltbr-out 15.193 HRD-in -65.24, -55.1 71.13, -2.53 out-out-out SNCooo out-out ActLoopNT-out 8.8875 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.47 APE8-dihe-out -89.38, 6.07 APE8-rot-in 312.59 APE67-dihe-out -115.47, 140.44 -116.58, 113.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.5994 None None None XRAY 2.0 0.218 0.265 A 326.0 297.0 5 26 21 5 [[68, 361]] 1.0 7b94 Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7B94B Q02750 41 382 393.0 ANP:60401,T3W:60403 ATPlike,Type3 Inactive DFGin 5.8527 13.5104 BLBplus -134.32, 175.36 55.61, 39.25 -86.46, 153.65 39.68, 92.62 -72.74, 66.29 out-out out 15.1174 Saltbr-out 14.5478 HRD-in -66.3, -53.58 77.63, -11.98 out-out-out SNCooo out-out ActLoopNT-out 8.6174 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -40.61 APE8-rot-out 185.17 APE67-dihe-out -147.87, 139.4 -127.59, 154.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.218 0.265 B 326.0 293.0 5 26 21 5 [[68, 361]] 1.0 7b94 Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7B9LA Q02750 37 382 393.0 ANP:60401,T4N:60402 ATPlike,Type3 Inactive DFGin 6.1432 13.3849 BLBplus -137.56, 174.87 57.48, 45.06 -95.99, 156.93 43.03, 91.55 -78.34, 66.31 out-out out 15.2718 Saltbr-out 15.2434 HRD-in -67.86, -56.92 79.15, -7.52 out-out-none SNCoon out-none ActLoopNT-out 8.9677 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -119.38, 141.01 999.0, 135.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.194 0.214 A 326.0 295.0 7 26 19 7 [[68, 361]] 1.0 7b9l Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7B9LB Q02750 41 381 393.0 ANP:60401,T4N:60402 ATPlike,Type3 Inactive DFGin 5.9579 13.456 BLBplus -136.66, 175.43 56.67, 43.08 -92.39, 158.5 42.85, 91.66 -74.84, 62.99 out-out out 15.1558 Saltbr-out 14.9359 HRD-in -69.72, -56.61 80.29, -8.28 out-out-none SNCoon out-none ActLoopNT-out 8.6924 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -146.85, 137.07 999.0, 132.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.194 0.214 B 326.0 291.0 6 26 20 6 [[68, 361]] 1.0 7b9l Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3ORNA Q02750 62 380 393.0 ANP:60001,3OR:60400 ATPlike,Type3 Inactive DFGin 6.0287 13.8039 BLBplus -141.26, -171.81 51.14, 43.91 -94.56, 165.92 40.22, 96.28 -82.7, 73.49 out-out out 15.3451 Saltbr-out 15.2454 HRD-in -75.72, -51.63 76.11, -2.33 out-out-out SNCooo out-out ActLoopNT-out 9.2477 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -90.01, 161.45 APE9-dihe-na 75.09, 172.06 APE8-dihe-out -101.08, -27.15 APE8-rot-out 71.34 APE67-dihe-out -133.03, 139.32 -108.61, 153.73 APE12-dist-out 16.856 APE11-dist-out 20.6225 APE10-dist-out 18.5661 APE9-dist-out 13.0454 None None None XRAY 2.8 0.236 0.277 A 307.0 279.0 8 26 26 0 [[68, 361]] 1.0 3orn Homo sapiens STE_MAP2K1_HUMAN STE 9.7e-99 335.8 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3OS3A Q02750 62 378 393.0 ATP:1,3OS:400 ATPlike,Type3 Inactive DFGin 6.2398 13.5344 BLBplus -145.24, 170.05 62.26, 36.89 -93.68, 158.58 44.13, 99.29 -73.81, 106.93 out-out out 15.5039 Saltbr-out 15.3944 HRD-in -59.5, -62.21 84.93, 3.41 out-out-out SNCooo out-out ActLoopNT-out 9.408 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -133.7, -173.12 APE9-dihe-na 93.3, -146.81 APE8-dihe-out -139.28, -26.49 APE8-rot-out 64.05 APE67-dihe-out 179.14, 100.5 -105.07, -165.97 APE12-dist-out 14.8647 APE11-dist-out 20.0987 APE10-dist-out 20.8465 APE9-dist-out 14.0001 None None None XRAY 2.8 0.268 0.356 A 307.0 272.0 13 26 26 0 [[68, 361]] 1.0 3os3 Homo sapiens STE_MAP2K1_HUMAN STE 9.7e-99 335.8 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3WIGA Q02750 62 380 393.0 ANP:60401,CHU:60403 ATPlike,Type3 Inactive DFGin 6.2646 14.0156 BLBplus -143.18, 168.24 57.0, 43.27 -87.61, 167.58 35.17, 91.44 -81.11, 80.9 out-out out 15.2231 Saltbr-out 15.2345 HRD-in -81.12, -52.72 78.66, -9.66 out-out-out SNCooo out-out ActLoopNT-out 9.2519 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.56, 160.96 APE9-dihe-na 79.87, 168.49 APE8-dihe-out -95.77, -24.16 APE8-rot-out 58.57 APE67-dihe-out -134.06, 137.9 -112.83, 153.13 APE12-dist-out 16.5068 APE11-dist-out 20.1486 APE10-dist-out 18.5012 APE9-dist-out 12.9477 None None None XRAY 2.7 0.217 0.25 A 307.0 277.0 10 26 26 0 [[68, 361]] 1.0 3wig Homo sapiens STE_MAP2K1_HUMAN STE 9.7e-99 335.8 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3DV3A Q02750 62 382 393.0 ATP:69000,MEK:69001 ATPlike,Type3 Inactive DFGin 6.2483 13.6028 BLBplus -133.16, -177.92 60.69, 33.15 -89.5, 161.32 45.46, 91.05 -72.95, 66.6 out-out out 15.44 Saltbr-out 15.9198 HRD-in -71.02, -56.25 85.34, -10.2 out-out-out SNCooo out-out ActLoopNT-out 9.4338 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 147.19 APE8-dihe-out -113.44, 8.55 APE8-rot-out 63.26 APE67-dihe-out -136.65, 142.85 -161.65, 147.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.7228 None None None XRAY 2.3 0.184 0.221 A 322.0 287.0 34 26 23 3 [[68, 361]] 1.0 3dv3 Homo sapiens STE_MAP2K1_HUMAN STE 1.2e-97 332.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3MBLA Q02750 62 381 393.0 ADP:60535,LSG:60007 ATPlike,Type3 Inactive DFGin 6.3443 13.4033 BLBplus -137.82, 175.17 58.41, 36.59 -88.68, 159.6 41.78, 90.19 -90.36, 101.21 out-out out 15.5918 Saltbr-out 16.0041 HRD-in -72.77, -61.87 90.83, -9.53 out-out-out SNCooo out-out ActLoopNT-out 9.7788 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -62.62, 116.57 APE9-dihe-na -76.67, -13.86 APE8-dihe-out -100.19, -102.3 APE8-rot-out 48.6 APE67-dihe-out -109.33, 135.36 -59.01, 126.17 APE12-dist-out 18.7047 APE11-dist-out 17.8806 APE10-dist-out 19.945 APE9-dist-out 14.4728 None None None XRAY 2.6 0.169 0.215 A 328.0 289.0 31 26 26 0 [[68, 361]] 1.0 3mbl Homo sapiens STE_MAP2K1_HUMAN STE 1.3e-97 332.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3PP1A Q02750 62 382 393.0 ATP:60400,IZG:60500 ATPlike,Type3 Inactive DFGin 6.2434 13.5326 BLBplus -142.73, -172.37 57.21, 29.66 -83.48, 161.89 45.19, 86.92 -94.1, 95.51 out-out out 15.5755 Saltbr-out 15.6643 HRD-in -75.88, -59.97 91.29, -12.92 out-out-out SNCooo out-out ActLoopNT-out 9.8367 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -95.93, 115.09 APE9-dihe-na -80.03, 20.28 APE8-dihe-out -149.74, -167.9 APE8-rot-out 183.56 APE67-dihe-out -104.62, 136.28 16.12, 99.01 APE12-dist-out 17.8027 APE11-dist-out 17.6574 APE10-dist-out 19.8725 APE9-dist-out 14.6223 None None None XRAY 2.7 0.184 0.219 A 328.0 290.0 31 26 26 0 [[68, 361]] 1.0 3pp1 Homo sapiens STE_MAP2K1_HUMAN STE 1.3e-97 332.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3EQBA Q02750 62 382 393.0 ATP:69001,LUG:60001 ATPlike,Type3 Inactive DFGin 6.3666 13.8165 BLBplus -126.21, -166.87 50.54, 41.27 -103.19, 173.93 44.2, 81.11 -86.45, 70.56 out-out out 15.5513 Saltbr-out 16.0995 HRD-in -69.12, -59.32 92.15, -13.52 out-out-out SNCooo out-out ActLoopNT-out 9.4116 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -145.13 APE9-dihe-na 160.93, -130.46 APE8-dihe-out -134.08, -9.84 APE8-rot-out 185.08 APE67-dihe-out -100.78, 136.47 -136.54, 109.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.269 APE9-dist-out 13.0736 None None None XRAY 2.62 0.212 0.264 A 333.0 288.0 33 26 23 3 [[68, 361]] 1.0 3eqb Homo sapiens STE_MAP2K1_HUMAN STE 1.4e-97 332.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 4U80A Q02750 62 379 393.0 ANP:60501,3EX:60502 ATPlike,Type3 Inactive DFGin 6.1423 13.3581 BLBplus -137.92, -179.3 57.25, 41.8 -100.21, 164.46 49.55, 87.81 -82.1, 69.9 out-out out 15.3907 Saltbr-out 16.1744 HRD-in -63.5, -60.19 86.1, -12.96 out-out-out SNCooo out-out ActLoopNT-out 9.1744 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, -56.89 APE9-dihe-na 91.88, -152.59 APE8-dihe-out -126.68, 10.89 APE8-rot-in 310.84 APE67-dihe-out -98.05, 140.26 -155.43, 115.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.5568 APE9-dist-out 13.4268 None None None XRAY 2.8 0.167 0.224 A 341.0 285.0 33 26 23 3 [[68, 361]] 1.0 4u80 Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 1S9JA Q02750 62 382 393.0 ATP:60535,BBM:61001 ATPlike,Type3 Inactive DFGin 6.0381 13.6765 BLBplus -128.29, 177.35 60.26, 51.07 -106.68, 166.27 42.89, 83.29 -88.36, 87.09 out-out out 15.6483 Saltbr-out 16.0046 HRD-in -74.19, -52.1 76.2, -2.79 out-out-out SNCooo out-out ActLoopNT-out 9.3469 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -65.48 APE9-dihe-na 93.04, 154.36 APE8-dihe-out -82.85, 11.58 APE8-rot-out 188.1 APE67-dihe-out -101.56, 129.66 -130.71, 111.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.1483 APE9-dist-out 12.5588 None None None XRAY 2.4 0.246 0.269 A 341.0 288.0 33 26 23 3 [[68, 361]] 1.0 1s9j Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3DY7A Q02750 62 364 393.0 ATP:9000,1CX:9002 ATPlike,Type3 Inactive DFGin 6.1717 13.7583 BLBplus -135.89, -175.79 54.31, 45.87 -100.93, 164.77 46.33, 84.08 -87.96, 76.55 out-out out 15.2441 Saltbr-out 15.5792 HRD-in -80.68, -50.01 86.81, -10.3 out-out-out SNCooo out-out ActLoopNT-out 9.4633 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -93.77 APE8-dihe-out -68.47, -78.94 APE8-rot-in 288.45 APE67-dihe-out -129.83, 139.32 -78.41, 146.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.0637 None None None XRAY 2.7 0.248 0.269 A 341.0 260.0 43 26 23 3 [[68, 361]] 1.0 3dy7 Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3E8NA Q02750 62 382 393.0 ATP:60600,VRA:61001 ATPlike,Type3 Inactive DFGin 6.1947 13.8185 BLBplus -141.11, 177.37 57.45, 45.25 -100.77, 153.06 46.07, 82.11 -71.63, 93.26 out-out out 15.4133 Saltbr-out 15.3475 HRD-in -66.77, -56.92 83.67, -13.1 out-out-out SNCooo out-out ActLoopNT-out 9.4321 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_onoo APE10-dihe-na 999.0, -90.03 APE9-dihe-na 88.43, 141.27 APE8-dihe-out -49.1, -69.8 APE8-rot-out 147.13 APE67-dihe-out -116.51, 140.9 -59.5, 122.62 APE12-dist-out 18.8826 APE11-dist-none 999.0 APE10-dist-out 19.9857 APE9-dist-out 12.8311 None None None XRAY 2.5 0.219 0.252 A 341.0 290.0 31 26 25 1 [[68, 361]] 1.0 3e8n Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3VVHA Q02750 62 382 393.0 ATP:60702,4BM:60703 ATPlike,Type3 Inactive DFGin 6.3887 13.6564 BLBplus -137.53, 173.5 63.48, 33.18 -82.96, 158.78 37.49, 96.63 -83.81, 69.64 out-out out 15.318 Saltbr-out 14.9475 HRD-in -72.04, -55.34 81.65, -10.46 out-out-out SNCooo out-out ActLoopNT-out 9.2611 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -67.32 APE8-rot-in 311.04 APE67-dihe-out -121.47, 130.33 -95.91, 138.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.199 0.225 A 341.0 286.0 35 26 21 5 [[68, 361]] 1.0 3vvh Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3VVHB Q02750 62 382 393.0 ATP:60502,4BM:60503 ATPlike,Type3 Inactive DFGin 6.1391 13.837 BLBplus -134.79, 175.55 59.54, 35.53 -87.99, 165.28 42.27, 92.99 -92.68, 76.34 out-out out 15.2611 Saltbr-out 14.9773 HRD-in -72.52, -58.36 78.03, -3.83 out-out-out SNCooo out-out ActLoopNT-out 9.105 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -110.08, 147.03 APE9-dihe-na 98.19, 168.29 APE8-dihe-out -85.55, -32.58 APE8-rot-in 303.1 APE67-dihe-out -124.7, 138.59 -110.8, 145.07 APE12-dist-out 16.9705 APE11-dist-out 20.5595 APE10-dist-out 18.8507 APE9-dist-out 12.9264 None None None XRAY 2.0 0.199 0.225 B 341.0 289.0 32 26 26 0 [[68, 361]] 1.0 3vvh Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3VVHC Q02750 62 381 393.0 ATP:60502,4BM:60503 ATPlike,Type3 Inactive DFGin 6.1194 13.8842 BLBplus -136.04, 173.19 62.4, 33.8 -87.32, 164.72 43.72, 90.03 -81.06, 61.43 out-out out 15.3952 Saltbr-out 14.9059 HRD-in -71.92, -60.52 80.82, -10.24 out-out-out SNCooo out-out ActLoopNT-out 9.0055 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -107.33, 145.59 APE9-dihe-na 98.43, 176.47 APE8-dihe-out -99.48, -17.12 APE8-rot-out 62.73 APE67-dihe-out -124.21, 136.5 -120.29, 144.56 APE12-dist-out 16.9183 APE11-dist-out 20.6229 APE10-dist-out 18.8043 APE9-dist-out 12.9647 None None None XRAY 2.0 0.199 0.225 C 341.0 282.0 38 26 26 0 [[68, 361]] 1.0 3vvh Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 4ARKA Q02750 62 382 393.0 ADP:61383,M3K:61385 ATPlike,Type3 Inactive DFGin 6.213 13.3205 BLBplus -143.7, -171.53 62.76, 23.96 -76.11, 159.51 42.79, 94.02 -85.45, 75.28 out-out out 15.3534 Saltbr-out 15.901 HRD-in -67.47, -65.14 92.89, -4.81 out-out-out SNCooo out-out ActLoopNT-out 9.3292 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -100.98, -15.83 APE9-dihe-na -32.88, 128.59 APE8-dihe-out -40.11, 20.06 APE8-rot-out 186.45 APE67-dihe-out -132.58, 138.09 -155.02, 124.88 APE12-dist-out 16.3492 APE11-dist-out 18.1392 APE10-dist-out 23.5537 APE9-dist-out 14.4262 None None None XRAY 2.6 0.174 0.211 A 341.0 290.0 31 26 26 0 [[68, 361]] 1.0 4ark Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 4LMNA Q02750 62 382 393.0 ANP:60501,EUI:60503 ATPlike,Type3 Inactive DFGin 6.1087 13.4073 BLBplus -150.33, -178.45 56.52, 30.25 -84.69, 155.37 45.37, 87.33 -80.58, 74.43 out-out out 15.5596 Saltbr-out 15.7763 HRD-in -60.71, -57.05 86.56, -12.8 out-out-out SNCooo out-out ActLoopNT-out 9.0127 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.36, -106.55 APE9-dihe-na -110.69, -4.9 APE8-dihe-out -94.39, -2.53 APE8-rot-out 38.79 APE67-dihe-out -120.37, 128.01 -144.86, 111.2 APE12-dist-out 20.4741 APE11-dist-out 19.7321 APE10-dist-out 22.049 APE9-dist-out 15.3113 None None None XRAY 2.8 0.193 0.233 A 341.0 291.0 30 26 26 0 [[68, 361]] 1.0 4lmn Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 4MNEE Q02750 62 379 393.0 ACP:901,573:903 ATPlike,Type3 Inactive DFGin 6.3012 13.7407 BLBplus -139.17, 176.14 61.58, 40.21 -96.23, 153.1 47.97, 96.35 -69.87, 64.71 out-out out 15.7956 Saltbr-out 16.1573 HRD-in -84.17, -39.22 69.48, -27.4 out-out-out SNCooo out-out ActLoopNT-out 9.2771 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -76.04, 124.0 APE9-dihe-na -78.04, -178.79 APE8-dihe-out -111.0, -36.1 APE8-rot-out 69.56 APE67-dihe-out -140.43, 146.63 -132.48, 167.21 APE12-dist-out 17.6629 APE11-dist-out 21.7751 APE10-dist-out 24.2369 APE9-dist-out 13.5531 None None None XRAY 2.848 0.186 0.24 E 341.0 286.0 32 26 26 0 [[68, 361]] 1.0 4mne Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3EQGA Q02750 39 381 393.0 ADP:2,4BM:1 ATPlike,Type3 Inactive DFGin 6.6055 13.7427 BLBplus -138.18, 179.2 59.31, 28.5 -81.55, 153.56 35.8, 92.23 -71.67, 64.14 out-out out 15.4736 Saltbr-out 14.5657 HRD-in -60.95, -65.33 94.63, -12.32 out-out-out SNCooo out-out ActLoopNT-out 9.2307 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -104.38, 152.44 APE9-dihe-na -137.47, 114.08 APE8-dihe-in -13.21, 123.19 APE8-rot-out 216.51 APE67-dihe-in -71.17, -7.71 -101.04, 15.41 APE12-dist-out 19.79 APE11-dist-out 16.5602 APE10-dist-out 18.8547 APE9-dist-out 9.489 S298N,S299K,Y300F None None XRAY 2.5 0.21 0.273 A 360.0 314.0 29 26 26 0 [[68, 361]] 1.0 3eqg Homo sapiens STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7UMBC Q02750 41 381 393.0 ANP:401,U9F:402 ATPlike,Type3 Inactive DFGin 6.169 13.7668 BLBplus -162.24, 171.11 70.21, 49.7 -113.95, 160.88 44.65, 94.08 -79.06, 81.13 out-out out 15.5589 Saltbr-out 15.2725 HRD-in -66.12, -48.09 76.83, -9.86 out-out-out SNCooo out-out ActLoopNT-out 9.5911 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -127.94, 139.36 APE9-dihe-na -138.86, -160.81 APE8-dihe-out -82.2, -18.64 APE8-rot-out 50.9 APE67-dihe-out -106.39, 139.13 -104.8, 110.61 APE12-dist-out 16.6992 APE11-dist-out 19.6656 APE10-dist-out 21.5701 APE9-dist-out 14.915 None None None XRAY 3.231 0.231 0.268 C 384.0 303.0 38 26 26 0 [[68, 361]] 1.0 7umb Homo sapiens STE_MAP2K1_HUMAN STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 6PP9B Q02750 38 383 393.0 ANP:801,LCJ:803 ATPlike,Type3 Inactive DFGin 6.0507 13.8503 BLBplus -152.52, 171.62 57.53, 41.01 -92.48, 164.33 45.1, 87.01 -81.4, 67.83 out-out out 15.4693 Saltbr-out 15.3255 HRD-in -69.19, -57.7 73.02, -1.06 out-out-out SNCooo out-out ActLoopNT-out 8.325 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -150.75, 155.46 APE9-dihe-na -104.35, -179.3 APE8-dihe-out -103.86, -21.71 APE8-rot-out 60.0 APE67-dihe-out -161.36, 138.21 -120.01, -175.99 APE12-dist-out 17.6293 APE11-dist-out 18.0984 APE10-dist-out 21.1907 APE9-dist-out 12.1845 S218A,S222A None None XRAY 2.59 0.222 0.245 B 397.0 314.0 32 26 26 0 [[68, 361]] 1.0 6pp9 Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7M0VB Q02750 42 383 393.0 ANP:801,EUI:803 ATPlike,Type3 Inactive DFGin 6.0381 13.7379 BLBplus -152.98, 176.74 51.89, 40.05 -97.58, 155.01 48.54, 94.68 -74.32, 76.65 out-out out 15.3562 Saltbr-out 15.2475 HRD-in -53.62, -41.23 79.48, -8.01 out-out-out SNCooo out-out ActLoopNT-out 8.4508 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -59.78, 136.18 APE9-dihe-na -90.07, -164.06 APE8-dihe-out -111.55, -13.91 APE8-rot-out 80.18 APE67-dihe-out -157.27, 123.12 -113.49, 175.2 APE12-dist-out 17.7535 APE11-dist-out 19.5873 APE10-dist-out 21.2162 APE9-dist-out 13.438 S218A,S222A None None XRAY 3.16 0.188 0.234 B 397.0 310.0 32 26 26 0 [[68, 361]] 1.0 7m0v Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7M0WB Q02750 42 383 393.0 ANP:801,QOA:803 ATPlike,Type3 Inactive DFGin 6.1482 14.0545 BLBplus -157.1, -177.15 57.47, 39.21 -94.37, 139.97 49.64, 89.26 -60.24, 75.28 out-out out 15.239 Saltbr-out 15.1806 HRD-in -60.24, -53.72 67.58, 4.61 out-out-out SNCooo out-out ActLoopNT-out 8.8656 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -57.72, 142.94 APE9-dihe-na -85.2, -169.93 APE8-dihe-out -102.45, -22.28 APE8-rot-out 37.77 APE67-dihe-out -129.82, 144.3 -151.67, 158.88 APE12-dist-out 17.5121 APE11-dist-out 22.6571 APE10-dist-out 23.4774 APE9-dist-out 13.5899 S218A,S222A None None XRAY 3.09 0.197 0.233 B 397.0 310.0 32 26 26 0 [[68, 361]] 1.0 7m0w Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7M0XB Q02750 40 383 393.0 ANP:801,4BM:803 ATPlike,Type3 Inactive DFGin 6.0399 13.7075 BLBplus -145.13, 173.52 62.48, 32.29 -85.3, 166.26 43.84, 89.91 -82.62, 63.8 out-out out 15.2193 Saltbr-out 15.1277 HRD-in -57.93, -57.46 71.94, -0.74 out-out-out SNCooo out-out ActLoopNT-out 8.3308 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.02, 147.44 APE9-dihe-na -87.47, -179.23 APE8-dihe-out -111.82, -15.11 APE8-rot-out 56.07 APE67-dihe-out -151.04, 140.91 -141.23, 175.81 APE12-dist-out 17.7952 APE11-dist-out 17.9191 APE10-dist-out 21.3926 APE9-dist-out 11.9857 S218A,S222A None None XRAY 2.47 0.18 0.215 B 397.0 312.0 32 26 26 0 [[68, 361]] 1.0 7m0x Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7M0YB Q02750 43 382 393.0 ANP:401,QOM:404 ATPlike,Type3 Inactive DFGin 5.9314 13.9674 BLBplus -158.94, 162.56 56.25, 36.06 -89.69, 147.0 54.27, 82.92 -67.13, 108.1 out-out out 15.4927 Saltbr-out 15.9617 HRD-in -58.74, -61.39 74.04, 6.51 out-out-out SNCooo out-out ActLoopNT-out 9.4018 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -63.76, 140.76 APE9-dihe-na -82.11, -165.89 APE8-dihe-out -109.48, -23.44 APE8-rot-out 48.75 APE67-dihe-out -133.69, 134.38 -151.5, 158.4 APE12-dist-out 17.3805 APE11-dist-out 22.4528 APE10-dist-out 23.379 APE9-dist-out 13.66 S218A,S222A None None XRAY 3.45 0.196 0.218 B 397.0 308.0 32 26 26 0 [[68, 361]] 1.0 7m0y Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7M0ZB Q02750 42 383 393.0 ANP:401,CHU:402 ATPlike,Type3 Inactive DFGin 6.1064 14.1069 BLBplus -160.77, 175.85 59.87, 41.63 -97.41, 152.84 45.88, 80.73 -66.99, 92.55 out-out out 15.4927 Saltbr-out 15.371 HRD-in -96.91, -40.79 69.65, -8.88 out-out-out SNCooo out-out ActLoopNT-out 9.612 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -66.4, 138.99 APE9-dihe-na -84.75, -165.15 APE8-dihe-out -106.74, -38.37 APE8-rot-out 38.19 APE67-dihe-out -129.38, 138.55 -136.73, 157.33 APE12-dist-out 17.2133 APE11-dist-out 22.3822 APE10-dist-out 23.6126 APE9-dist-out 13.6034 S218A,S222A None None XRAY 3.12 0.193 0.225 B 397.0 310.0 32 26 26 0 [[68, 361]] 1.0 7m0z Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 8DGTB Q02750 43 385 393.0 AGS:60402,LCJ:60403 ATPlike,Type3 Inactive DFGin 5.9682 13.5357 BLBplus -152.99, 179.37 55.42, 45.61 -100.12, 157.06 44.99, 96.32 -80.94, 77.56 out-out out 15.5691 Saltbr-out 15.7331 HRD-in -64.15, -51.45 68.84, -11.98 out-out-out SNCooo out-out ActLoopNT-out 8.9452 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -67.75, 131.31 APE9-dihe-na -82.42, -172.83 APE8-dihe-out -101.84, -12.18 APE8-rot-out 77.74 APE67-dihe-out -124.11, 144.61 -162.74, 152.77 APE12-dist-out 16.6735 APE11-dist-out 21.6272 APE10-dist-out 23.2855 APE9-dist-out 13.7054 S218A,S222A None None EM 3.9 999.0 999.0 B 414.0 311.0 32 26 26 0 [[68, 361]] 1.0 8dgt Homo sapiens STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 6NYBB Q02750 56 383 393.0 ADP:60601,LCJ:60901 ATPlike,Type3 Inactive DFGin 5.9588 14.0365 BLBplus -152.28, 170.52 57.47, 42.76 -92.93, 161.49 47.46, 85.53 -88.41, 68.49 out-out out 15.4696 Saltbr-out 17.6022 HRD-in -56.15, -54.04 65.39, 11.35 out-out-out SNCooo out-out ActLoopNT-out 8.2916 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.81, 127.27 APE9-dihe-na -93.66, 157.79 APE8-dihe-out -110.82, -26.16 APE8-rot-out 55.56 APE67-dihe-out -130.29, 148.43 -119.13, 133.87 APE12-dist-out 17.78 APE11-dist-out 18.3191 APE10-dist-out 22.3789 APE9-dist-out 12.1589 S218A,S222A None None EM 4.1 999.0 999.0 B 415.0 289.0 39 26 26 0 [[68, 361]] 1.0 6nyb Homo sapiens STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9MMPB Q02750 62 380 393.0 AGS:60701,LCJ:60702 ATPlike,Type3 Inactive DFGin 6.4937 13.7015 BLBplus -142.17, 163.3 59.56, 65.37 -113.14, 157.69 39.56, 95.33 -79.99, 73.26 out-out out 15.7564 Saltbr-out 16.3325 HRD-in -69.63, -60.91 71.6, -9.27 out-out-out SNCooo out-out ActLoopNT-out 8.0011 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -73.57, 130.1 APE9-dihe-na -94.62, 178.33 APE8-dihe-out -96.1, -46.02 APE8-rot-in 278.39 APE67-dihe-out -136.63, 147.99 -117.77, 157.18 APE12-dist-out 17.2275 APE11-dist-out 22.2405 APE10-dist-out 24.3959 APE9-dist-out 13.7692 S218A,S222A None None EM 3.4 999.0 999.0 B 415.0 279.0 40 26 26 0 [[68, 361]] 1.0 9mmp Homo sapiens STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9MMQB Q02750 62 380 393.0 AGS:701,LCJ:703 ATPlike,Type3 Inactive DFGin 6.6749 13.4889 BLBplus -138.6, 170.41 60.57, 44.79 -97.28, 158.99 35.24, 93.11 -75.64, 83.14 out-out out 15.4214 Saltbr-out 15.6346 HRD-in -61.2, -52.92 69.79, -9.3 out-out-out SNCooo out-out ActLoopNT-out 9.0103 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -65.78, 148.58 APE9-dihe-na -99.52, -176.8 APE8-dihe-out -104.42, -44.51 APE8-rot-in 299.56 APE67-dihe-out -150.89, 153.99 -135.56, 174.2 APE12-dist-out 17.2664 APE11-dist-out 22.0929 APE10-dist-out 24.0771 APE9-dist-out 13.54 S218A,S222A None None EM 2.9 999.0 999.0 B 415.0 279.0 40 26 26 0 [[68, 361]] 1.0 9mmq Homo sapiens STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9MMRB Q02750 62 380 393.0 AGS:60701,LCJ:60703 ATPlike,Type3 Inactive DFGin 6.847 13.5448 BLBplus -144.47, 166.22 62.86, 45.64 -102.79, 155.22 38.56, 95.23 -78.03, 72.6 out-out out 15.3255 Saltbr-out 15.7338 HRD-in -59.38, -50.94 68.52, -2.49 out-out-out SNCooo out-out ActLoopNT-out 8.9519 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -61.82, 155.36 APE9-dihe-na -107.83, -179.82 APE8-dihe-out -105.89, -53.41 APE8-rot-in 308.85 APE67-dihe-out -136.82, 148.35 -127.86, 156.49 APE12-dist-out 17.0348 APE11-dist-out 22.0064 APE10-dist-out 24.0306 APE9-dist-out 13.5803 S218A,S222A None None EM 3.9 999.0 999.0 B 415.0 279.0 40 26 26 0 [[68, 361]] 1.0 9mmr Homo sapiens STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9MMSB Q02750 63 380 393.0 AGS:701,LCJ:703 ATPlike,Type3 Inactive DFGin 6.8547 13.563 BLBplus -141.52, 164.23 63.42, 46.21 -99.5, 165.31 34.19, 90.42 -80.53, 73.26 out-out out 15.4077 Saltbr-out 15.7694 HRD-in -66.2, -52.71 70.98, -11.79 out-out-out SNCooo out-out ActLoopNT-out 8.8575 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -63.41, 150.0 APE9-dihe-na -102.92, -178.46 APE8-dihe-out -108.1, -35.69 APE8-rot-in 324.75 APE67-dihe-out -152.78, 143.47 -133.76, 175.52 APE12-dist-out 17.2823 APE11-dist-out 22.2166 APE10-dist-out 24.3527 APE9-dist-out 13.6751 S218A,S222A None None EM 3.3 999.0 999.0 B 415.0 278.0 40 26 26 0 [[68, 361]] 1.0 9mms Homo sapiens STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 4MNEH Q02750 66 380 393.0 ACP:901,573:903,573:904 ATPlike,Type3,Allosteric Inactive DFGin 6.3776 13.8909 BLBplus -149.03, 175.24 52.75, 36.33 -93.4, 157.98 53.98, 84.28 -78.54, 56.84 out-out out 15.8147 Saltbr-out 15.4559 HRD-in -72.48, -51.28 80.05, -1.12 out-out-out SNCooo out-out ActLoopNT-out 9.1113 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -63.87, 146.83 APE9-dihe-na -98.86, 164.39 APE8-dihe-out -71.61, -59.39 APE8-rot-in 294.12 APE67-dihe-out -156.42, 156.79 -128.0, -169.25 APE12-dist-out 17.7474 APE11-dist-out 21.8877 APE10-dist-out 24.1565 APE9-dist-out 13.6645 None None None XRAY 2.848 0.186 0.24 H 341.0 275.0 40 26 26 0 [[68, 361]] 1.0 4mne Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9AXMC Q02750 43 376 393.0 A1AHE:60401 Type1 Inactive DFGin 6.668 14.1318 BLBplus -150.29, 169.67 59.1, 61.29 -116.51, 166.39 40.92, 86.38 -72.68, 94.97 out-none out 15.3794 Saltbr-none 999.0 HRD-in -102.21, -42.14 67.4, -10.68 none-out-out SNCnoo out-out ActLoopNT-out 9.7501 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -64.72, 121.05 APE9-dihe-na -67.96, 179.71 APE8-dihe-out -110.15, -27.15 APE8-rot-out 56.89 APE67-dihe-out -127.4, 134.54 -138.28, 164.48 APE12-dist-out 17.1619 APE11-dist-out 22.1776 APE10-dist-out 24.2389 APE9-dist-out 13.2396 S218A,S222A None None XRAY 2.42 0.263 0.301 C 310.0 290.0 0 26 26 0 [[68, 361]] 1.0 9axm Homo sapiens STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7PQVA Q02750 39 382 393.0 80C:401 Type1 Inactive DFGin 5.4336 14.6802 BLBplus -142.2, 171.85 61.45, 42.08 -85.79, 152.48 48.85, 90.13 -67.98, 114.43 out-out out 15.5242 Saltbr-out 14.5103 HRD-in -71.75, -53.29 78.98, -5.23 out-out-out SNCooo out-out ActLoopNT-out 10.8553 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -72.38 APE9-dihe-na -75.93, 162.49 APE8-dihe-in -64.45, 139.43 APE8-rot-out 186.6 APE67-dihe-in -68.45, -13.06 -104.01, 6.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.4546 APE9-dist-out 9.4566 None None None XRAY 2.13 0.239 0.287 A 344.0 310.0 34 26 23 3 [[68, 361]] 1.0 7pqv Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3ZLSA Q02750 39 382 393.0 92P:1383 Type1 Inactive DFGin 6.349 13.9016 BLBplus -142.39, 168.81 61.5, 49.05 -105.64, 135.16 48.47, 88.72 -55.27, 109.43 out-out out 15.2616 Saltbr-out 14.1732 HRD-in -68.12, -60.88 87.92, -13.42 out-out-out SNCooo out-out ActLoopNT-out 10.7509 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -114.56, 4.84 APE9-dihe-na 122.52, 156.26 APE8-dihe-in -53.81, 153.4 APE8-rot-out 184.69 APE67-dihe-in -61.22, -14.41 -106.03, 1.34 APE12-dist-out 17.359 APE11-dist-out 18.4642 APE10-dist-out 12.8015 APE9-dist-out 9.1826 S298N,S299K,Y300K None None XRAY 2.5 0.195 0.234 A 348.0 315.0 29 26 26 0 [[68, 361]] 1.0 3zls Homo sapiens STE_MAP2K1_HUMAN STE 1.6e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3ZLXA Q02750 39 382 393.0 5EZ:1383 Type1 Inactive DFGin 6.1026 14.1175 BLBplus -137.36, 173.38 56.89, 45.75 -94.74, 137.54 39.99, 92.63 -59.78, 119.2 out-out out 15.3878 Saltbr-out 14.8632 HRD-in -65.83, -55.53 80.52, -17.62 out-out-out SNCooo out-out ActLoopNT-out 10.9147 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -19.39 APE9-dihe-na -73.81, 148.26 APE8-dihe-in -58.02, 134.08 APE8-rot-out 188.84 APE67-dihe-in -64.06, -14.63 -102.54, 3.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.7919 APE9-dist-out 9.3167 S298N,S299K,Y300K None None XRAY 2.2 0.205 0.236 A 348.0 312.0 32 26 23 3 [[68, 361]] 1.0 3zlx Homo sapiens STE_MAP2K1_HUMAN STE 1.6e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3ZM4A Q02750 40 382 393.0 22T:1383 Type1 Inactive DFGin 6.0389 13.8066 BLBplus -136.85, 171.85 55.05, 56.56 -104.8, 123.38 44.97, 93.25 -61.01, 124.18 out-out out 15.2158 Saltbr-out 15.3474 HRD-in -60.66, -53.09 74.75, -8.66 out-out-out SNCooo out-out ActLoopNT-out 11.019 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 152.25 APE8-dihe-in -64.64, 144.96 APE8-rot-out 192.59 APE67-dihe-in -62.95, -15.23 -105.08, 3.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.3981 S298N,S299K,Y300K None None XRAY 2.37 0.207 0.241 A 348.0 309.0 34 26 22 4 [[68, 361]] 1.0 3zm4 Homo sapiens STE_MAP2K1_HUMAN STE 1.6e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 5BX0A Q02750 39 382 393.0 4W5:4000 Type1 Inactive DFGin 6.9984 13.7672 BLBplus -136.8, 170.44 43.31, 54.65 -106.61, 136.84 50.08, 96.97 -61.42, 106.18 out-out out 14.9264 Saltbr-out 13.5457 HRD-in -68.32, -52.05 72.06, 2.25 out-out-out SNCooo out-out ActLoopNT-out 10.0285 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na 57.15, 101.55 APE9-dihe-na -59.91, 145.17 APE8-dihe-in -61.27, 132.45 APE8-rot-out 189.37 APE67-dihe-in -64.93, -20.22 -94.27, 3.12 APE12-dist-out 16.3413 APE11-dist-out 15.576 APE10-dist-out 16.6316 APE9-dist-out 8.1509 None None None XRAY 2.93 0.2 0.252 A 348.0 315.0 29 26 26 0 [[68, 361]] 1.0 5bx0 Homo sapiens STE_MAP2K1_HUMAN STE 1.6e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7XNCA Q02750 37 382 393.0 GIK:401 Type1 Inactive DFGin 5.8947 14.8252 BLBplus -156.03, 175.21 61.47, 34.29 -87.45, 138.03 47.2, 91.86 -58.36, 113.33 out-out out 15.4222 Saltbr-out 14.2443 HRD-in -73.45, -50.27 75.24, -7.95 out-out-out SNCooo out-out ActLoopNT-out 10.6397 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 172.59 APE9-dihe-na -67.78, 157.57 APE8-dihe-in -67.44, 146.19 APE8-rot-out 185.87 APE67-dihe-in -70.1, -4.65 -109.72, 7.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.2585 APE9-dist-out 9.409 S298N,S299K,Y300K None None XRAY 2.1 0.227 0.251 A 348.0 311.0 35 26 23 3 [[68, 361]] 1.0 7xnc Homo sapiens STE_MAP2K1_HUMAN STE 1.6e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3ZLYA Q02750 40 382 393.0 YSO:1383 Type1 Inactive DFGin 6.0219 13.9264 BLBplus -136.5, 174.92 53.79, 50.97 -96.94, 123.0 39.07, 92.61 -57.89, 125.23 out-out out 15.3139 Saltbr-out 14.8952 HRD-in -64.76, -55.59 79.69, -12.84 out-out-out SNCooo out-out ActLoopNT-out 10.9518 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 59.75 APE9-dihe-na -59.24, 161.77 APE8-dihe-in -58.7, 148.28 APE8-rot-out 187.92 APE67-dihe-in -66.68, -11.75 -105.31, 5.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.0996 APE9-dist-out 9.5312 S298N,S299N,Y300K None None XRAY 2.11 0.201 0.248 A 348.0 310.0 33 26 23 3 [[68, 361]] 1.0 3zly Homo sapiens STE_MAP2K1_HUMAN STE 1.6e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 5EYMA Q02750 41 381 393.0 5U5:401 Type1 Inactive DFGin 6.0591 15.6595 BLBplus -120.98, 147.02 60.26, 74.87 -99.88, 172.08 67.77, 94.18 -95.96, 104.23 out-out out 14.9434 Saltbr-out 14.6369 HRD-out -97.04, 164.44 -129.86, 87.96 out-out-out SNCooo out-out ActLoopNT-out 9.8393 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 170.38 APE8-rot-out 191.89 APE67-dihe-in -94.98, 9.32 -122.76, 22.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S298N,S299K,Y300F None None XRAY 2.7 0.247 0.308 A 359.0 292.0 49 26 20 6 [[68, 361]] 1.0 5eym Homo sapiens STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 5EYMB Q02750 41 381 393.0 5U5:401 Type1 Inactive DFGin 5.8473 15.517 BLBplus -137.53, 139.28 62.1, 82.03 -101.81, 135.65 61.97, 95.79 -72.99, 85.77 out-out out 14.8463 Saltbr-out 13.9051 HRD-out -85.96, 166.94 -128.86, 78.44 out-out-out SNCooo out-out ActLoopNT-out 9.7495 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 169.8 APE8-rot-out 190.32 APE67-dihe-in -105.42, 16.51 -133.2, 32.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S298N,S299K,Y300F None None XRAY 2.7 0.247 0.308 B 359.0 292.0 49 26 20 6 [[68, 361]] 1.0 5eym Homo sapiens STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3EQFA Q02750 39 381 393.0 KSA:1 Type1 Inactive DFGin 6.2432 13.6637 BLBplus -153.33, 163.29 80.11, 34.98 -102.11, 118.04 52.83, 85.59 -46.9, 139.99 out-out out 14.5589 Saltbr-out 13.0772 HRD-in -93.89, -53.62 76.18, 0.04 out-out-out SNCooo out-out ActLoopNT-out 10.9093 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -158.82, 130.87 APE9-dihe-na -108.44, 177.3 APE8-dihe-in -83.48, 167.0 APE8-rot-out 171.06 APE67-dihe-in -59.57, -9.61 -127.22, 12.73 APE12-dist-out 19.7055 APE11-dist-out 14.97 APE10-dist-out 17.1123 APE9-dist-out 9.569 S298N,S299K,Y300F None None XRAY 2.7 0.257 999.0 A 360.0 314.0 29 26 26 0 [[68, 361]] 1.0 3eqf Homo sapiens STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9O0UB Q02750 30 380 393.0 CHU:401 Type1 Inactive DFGin 6.1693 14.0852 BLBplus -152.21, 168.43 59.39, 48.73 -101.51, 163.52 46.19, 86.69 -79.7, 84.36 out-out out 15.4302 Saltbr-out 16.8168 HRD-in -71.69, -48.17 74.87, -6.64 out-out-out SNCooo out-out ActLoopNT-out 9.681 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -135.55, 157.08 APE9-dihe-na -122.47, 145.42 APE8-dihe-out -102.69, -27.28 APE8-rot-in 280.53 APE67-dihe-out -148.15, 135.27 -137.0, 174.84 APE12-dist-out 16.861 APE11-dist-out 17.0165 APE10-dist-out 21.8105 APE9-dist-out 12.4425 S218A,S222A None None XRAY 2.91 0.232 0.264 B 395.0 322.0 29 26 26 0 [[68, 361]] 1.0 9o0u Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3ZLWA Q02750 39 382 393.0 MT8:1383 Type1 Inactive DFGin 6.1457 14.2171 BLBplus -141.88, 175.47 52.4, 41.68 -90.51, 130.61 42.74, 93.08 -63.08, 114.26 out-out out 15.481 Saltbr-out 14.3533 HRD-in -65.75, -51.92 80.2, -17.86 out-out-out SNCooo out-out ActLoopNT-out 10.9546 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 36.62 APE9-dihe-na -53.09, 161.09 APE8-dihe-in -56.49, 143.1 APE8-rot-out 192.65 APE67-dihe-in -68.31, -12.99 -103.26, 6.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.0559 APE9-dist-out 9.5048 S298N,S299K,Y300F None None XRAY 2.12 0.198 0.248 A 348.0 312.0 32 26 23 3 [[68, 361]] 1.0 3zlw Homo sapiens STE_MAP2K1_HUMAN STE 5.8e-96 326.8 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9AXHA Q02750 39 381 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.113 14.2053 BLBplus -138.52, 176.84 56.32, 45.26 -98.43, 166.79 48.45, 76.71 -79.29, 73.17 out-out out 15.3891 Saltbr-out 15.4608 HRD-in -79.27, -55.22 75.38, 2.3 out-out-out SNCooo out-out ActLoopNT-out 9.3908 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -141.27, 126.74 APE9-dihe-na -91.23, -150.48 APE8-dihe-out -108.84, -16.83 APE8-rot-out 178.7 APE67-dihe-out -130.79, 128.8 -115.86, 151.78 APE12-dist-out 17.4166 APE11-dist-out 17.6237 APE10-dist-out 20.8985 APE9-dist-out 13.1543 None None None XRAY 2.81 0.206 0.253 A 310.0 299.0 0 26 26 0 [[68, 361]] 1.0 9axh Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-98 335.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9AXHB Q02750 38 381 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.0283 13.959 BLBplus -143.4, 172.79 59.61, 49.11 -104.03, 163.1 47.48, 79.51 -74.37, 70.81 out-out out 15.4154 Saltbr-out 14.8168 HRD-in -76.49, -58.47 81.39, -4.23 out-out-out SNCooo out-out ActLoopNT-out 9.3218 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.95, 129.53 APE9-dihe-na -95.7, -172.17 APE8-dihe-out -83.87, -23.26 APE8-rot-out 67.32 APE67-dihe-out -134.03, 129.22 -119.03, 156.34 APE12-dist-out 17.3071 APE11-dist-out 17.5745 APE10-dist-out 20.8998 APE9-dist-out 12.718 None None None XRAY 2.81 0.206 0.253 B 310.0 300.0 0 26 26 0 [[68, 361]] 1.0 9axh Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-98 335.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9AXMA Q02750 38 382 393.0 A1AHE:60401,ANP:60403 Type1,ATPlike Inactive DFGin 6.2039 13.9992 BLBplus -146.84, 170.95 57.84, 58.3 -113.46, 158.4 47.1, 81.42 -71.93, 78.64 out-out out 15.4263 Saltbr-out 15.5133 HRD-in -80.25, -54.29 71.05, 3.5 out-out-out SNCooo out-out ActLoopNT-out 9.1102 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -58.81, 135.38 APE9-dihe-na -86.44, -174.93 APE8-dihe-out -114.7, -19.48 APE8-rot-out 61.33 APE67-dihe-out -156.42, 133.96 -137.25, 175.14 APE12-dist-out 17.3471 APE11-dist-out 22.1228 APE10-dist-out 24.2234 APE9-dist-out 13.2409 S218A,S222A None None XRAY 2.42 0.263 0.301 A 310.0 301.0 0 26 26 0 [[68, 361]] 1.0 9axm Homo sapiens STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9AXXA Q02750 41 382 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.1565 14.4729 BLBplus -142.21, 167.57 61.94, 40.19 -92.82, 170.58 38.95, 89.02 -82.21, 74.48 out-out out 15.9248 Saltbr-out 15.6608 HRD-in -77.34, -56.94 85.02, -11.71 out-out-out SNCooo out-out ActLoopNT-out 9.6225 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -70.01, 140.02 APE9-dihe-na -107.63, 178.58 APE8-dihe-out -103.64, -13.88 APE8-rot-out 56.98 APE67-dihe-out -152.18, 145.48 -132.34, 175.09 APE12-dist-out 18.633 APE11-dist-out 16.0857 APE10-dist-out 21.091 APE9-dist-out 12.7711 S218A,S222A None None XRAY 2.07 0.215 0.248 A 310.0 298.0 0 26 26 0 [[68, 361]] 1.0 9axx Homo sapiens STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9AXXC Q02750 37 378 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.0661 14.2508 BLBplus -153.34, 165.37 62.85, 41.08 -93.54, 164.6 44.67, 86.41 -75.31, 71.49 out-out out 15.5167 Saltbr-out 15.0221 HRD-in -80.68, -38.87 53.15, 7.3 out-out-out SNCooo out-out ActLoopNT-out 9.6912 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -68.91, 127.09 APE9-dihe-na -100.27, 169.31 APE8-dihe-out -98.12, -23.61 APE8-rot-out 61.42 APE67-dihe-out -153.77, 146.66 -125.41, 178.29 APE12-dist-out 18.4501 APE11-dist-out 16.1193 APE10-dist-out 21.5812 APE9-dist-out 12.7488 S218A,S222A None None XRAY 2.07 0.215 0.248 C 310.0 297.0 1 26 26 0 [[68, 361]] 1.0 9axx Homo sapiens STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9AYAB Q02750 42 382 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.2091 14.117 BLBplus -156.4, 169.03 57.59, 47.08 -100.39, 159.82 46.95, 83.0 -73.48, 80.99 out-out out 15.4442 Saltbr-out 14.9574 HRD-in -72.22, -50.64 78.5, -7.92 out-out-out SNCooo out-out ActLoopNT-out 9.725 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -67.32, 133.53 APE9-dihe-na -94.07, -169.54 APE8-dihe-out -110.54, -56.8 APE8-rot-out 71.18 APE67-dihe-out -155.6, 139.89 -98.61, 175.74 APE12-dist-out 17.2211 APE11-dist-out 22.1488 APE10-dist-out 24.1945 APE9-dist-out 13.7662 S218A,S222A None None XRAY 2.59 0.214 0.257 B 310.0 297.0 0 26 26 0 [[68, 361]] 1.0 9aya Homo sapiens STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9AYAD Q02750 39 382 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.236 14.1136 BLBplus -150.42, 169.48 62.14, 35.37 -84.74, 166.85 39.42, 88.37 -83.08, 73.44 out-out out 15.3824 Saltbr-out 15.2874 HRD-in -84.82, -56.5 86.5, -11.08 out-out-out SNCooo out-out ActLoopNT-out 9.653 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.69 APE8-dihe-out -103.38, -24.48 APE8-rot-out 47.89 APE67-dihe-out -161.23, 135.82 -100.94, -174.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.7487 S218A,S222A None None XRAY 2.59 0.214 0.257 D 310.0 293.0 7 26 23 3 [[68, 361]] 1.0 9aya Homo sapiens STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9AY7B Q02750 33 383 393.0 A1AHE:401,ANP:402 Type1,ATPlike Inactive DFGin 6.1312 14.2675 BLBplus -154.96, 169.08 61.0, 36.72 -91.6, 162.02 49.73, 81.71 -77.61, 77.19 out-out out 15.5132 Saltbr-out 15.4022 HRD-in -75.89, -55.94 83.29, -11.88 out-out-out SNCooo out-out ActLoopNT-out 9.5756 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -66.62, 136.57 APE9-dihe-na -89.93, -175.43 APE8-dihe-out -113.57, -10.62 APE8-rot-out 51.26 APE67-dihe-out -146.5, 144.85 -157.42, 170.13 APE12-dist-out 17.3436 APE11-dist-out 22.1142 APE10-dist-out 24.2068 APE9-dist-out 13.7295 S218A,S222A None None XRAY 2.41 0.203 0.236 B 394.0 322.0 29 26 26 0 [[68, 361]] 1.0 9ay7 Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9O0UH Q02750 30 380 393.0 CHU:401,ANP:402 Type1,ATPlike Inactive DFGin 6.2263 14.2396 BLBplus -153.68, 170.44 61.41, 47.24 -102.95, 164.39 45.69, 94.01 -79.55, 83.41 out-out out 15.5809 Saltbr-out 15.7853 HRD-in -74.86, -48.68 73.9, -6.25 out-out-out SNCooo out-out ActLoopNT-out 9.583 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -141.84, 152.52 APE9-dihe-na -130.16, 177.33 APE8-dihe-out -105.34, -25.09 APE8-rot-out 37.73 APE67-dihe-out -147.39, 136.35 -136.55, 176.51 APE12-dist-out 17.387 APE11-dist-out 17.659 APE10-dist-out 22.2151 APE9-dist-out 12.9967 S218A,S222A None None XRAY 2.91 0.232 0.264 H 395.0 315.0 36 26 26 0 [[68, 361]] 1.0 9o0u Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9O0VB Q02750 30 380 393.0 CHU:401,ANP:402 Type1,ATPlike Inactive DFGin 6.1927 14.1253 BLBplus -151.85, 167.5 59.4, 48.24 -102.03, 163.4 46.52, 86.88 -79.89, 84.21 out-out out 15.5955 Saltbr-out 16.8415 HRD-in -72.2, -48.2 74.46, -6.51 out-out-out SNCooo out-out ActLoopNT-out 9.7061 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -135.59, 156.7 APE9-dihe-na -122.67, 146.4 APE8-dihe-out -101.77, -26.6 APE8-rot-in 280.72 APE67-dihe-out -147.98, 135.29 -136.69, 175.09 APE12-dist-out 16.923 APE11-dist-out 17.129 APE10-dist-out 21.8624 APE9-dist-out 12.4292 S218A,S222A None None XRAY 3.5 0.208 0.254 B 395.0 322.0 29 26 26 0 [[68, 361]] 1.0 9o0v Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9O0VH Q02750 30 380 393.0 CHU:401,ANP:402 Type1,ATPlike Inactive DFGin 6.3491 14.2266 BLBplus -152.81, 169.25 61.22, 47.15 -103.13, 164.19 45.91, 94.17 -79.63, 83.31 out-out out 15.6315 Saltbr-out 15.9163 HRD-in -74.73, -48.72 73.54, -6.07 out-out-out SNCooo out-out ActLoopNT-out 9.5069 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -142.21, 151.98 APE9-dihe-na -130.61, 176.34 APE8-dihe-out -105.52, -25.24 APE8-rot-out 37.89 APE67-dihe-out -147.93, 136.16 -136.73, 176.12 APE12-dist-out 17.2775 APE11-dist-out 17.5835 APE10-dist-out 22.1521 APE9-dist-out 13.0006 S218A,S222A None None XRAY 3.5 0.208 0.254 H 395.0 318.0 33 26 26 0 [[68, 361]] 1.0 9o0v Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7XLPA Q02750 37 382 393.0 FZC:401 Type1.5_Back Inactive DFGin 6.2224 13.8185 BLBplus -149.23, 171.7 63.72, 39.53 -97.73, 126.21 51.37, 93.64 -69.1, 142.41 out-out out 15.2739 Saltbr-out 13.8233 HRD-in -68.97, -49.54 73.5, 1.6 out-out-out SNCooo out-out ActLoopNT-out 10.5524 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 129.04 APE8-dihe-in -69.42, 147.01 APE8-rot-out 179.16 APE67-dihe-in -70.91, -10.2 -108.37, 12.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.4117 S298N,S299K,Y300K None None XRAY 2.1 0.22 0.246 A 348.0 312.0 34 26 22 4 [[68, 361]] 1.0 7xlp Homo sapiens STE_MAP2K1_HUMAN STE 1.6e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7MFDB Q02750 52 383 393.0 CHU:401 Type3 Inactive DFGin 5.404 15.0019 BLBplus -158.62, 167.12 60.92, 63.61 -97.12, -175.46 63.42, 90.2 -85.78, 95.16 out-out out 16.3227 Saltbr-out 15.7256 HRD-in -63.97, -52.79 67.43, -4.72 out-out-out SNCooo out-out ActLoopNT-out 9.6757 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -74.44, -63.74 APE9-dihe-na 63.29, 177.26 APE8-dihe-out -134.0, -13.26 APE8-rot-out 186.3 APE67-dihe-out -128.3, 117.83 -113.33, 134.88 APE12-dist-out 15.8757 APE11-dist-out 14.2111 APE10-dist-out 20.3493 APE9-dist-out 12.7512 None None None EM 3.66 999.0 999.0 B 393.0 293.0 39 26 26 0 [[68, 361]] 1.0 7mfd Homo sapiens STE_MAP2K1_HUMAN STE 2.4e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9O2ZB Q02750 52 383 393.0 CHU:401 Type3 Inactive DFGin 5.6928 14.5575 BLBplus -161.53, 165.82 61.62, 61.08 -96.61, -171.26 43.54, 100.17 -85.43, 98.09 out-out out 16.5961 Saltbr-out 16.4609 HRD-in -72.32, -46.17 67.98, -6.22 out-out-out SNCooo out-out ActLoopNT-out 9.6467 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -91.74, -52.46 APE9-dihe-na 52.82, -171.67 APE8-dihe-out -137.35, -7.44 APE8-rot-out 199.8 APE67-dihe-out -140.63, 115.25 -121.25, 136.62 APE12-dist-out 16.3961 APE11-dist-out 14.2482 APE10-dist-out 20.3544 APE9-dist-out 13.1205 None None None EM 3.83 999.0 999.0 B 393.0 293.0 39 26 26 0 [[68, 361]] 1.0 9o2z Homo sapiens STE_MAP2K1_HUMAN STE 2.4e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9AXAB Q02750 52 380 393.0 A1AHE:401 Type3 Inactive DFGin 6.8129 13.7682 BLBplus -157.46, 170.37 59.28, 64.98 -117.48, 165.11 40.29, 81.19 -81.1, 74.19 out-out out 15.4311 Saltbr-out 17.4099 HRD-in -75.24, -42.64 72.38, -11.77 out-out-out SNCooo out-out ActLoopNT-out 9.2081 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -68.37, -62.71 APE9-dihe-na 103.09, 102.94 APE8-dihe-out -88.38, -48.33 APE8-rot-out 62.02 APE67-dihe-out -122.1, 131.17 -98.78, 143.35 APE12-dist-out 16.6961 APE11-dist-out 18.1264 APE10-dist-out 22.8521 APE9-dist-out 12.4243 S218A,S222A None None EM 4.36 999.0 999.0 B 394.0 278.0 51 26 26 0 [[68, 361]] 1.0 9axa Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9AXAD Q02750 59 383 393.0 A1AHE:401 Type3 Inactive DFGin 6.1878 15.038 BLBplus -161.59, 167.64 63.71, 27.36 -77.56, 162.55 63.45, 90.49 -80.72, 76.54 out-out out 17.6128 Saltbr-out 18.7979 HRD-in -103.62, -49.66 71.76, -9.27 out-out-out SNCooo out-out ActLoopNT-out 9.7971 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na 56.39, -81.94 APE9-dihe-na 48.87, 69.85 APE8-dihe-out -71.23, -18.7 APE8-rot-out 181.91 APE67-dihe-out -127.48, 156.86 -129.99, 139.21 APE12-dist-out 19.1615 APE11-dist-out 16.676 APE10-dist-out 21.3744 APE9-dist-out 12.2717 S218A,S222A None None EM 4.36 999.0 999.0 D 394.0 275.0 50 26 26 0 [[68, 361]] 1.0 9axa Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9AXCB Q02750 52 380 393.0 A1AHE:401 Type3 Inactive DFGin 5.9787 13.8572 BLBplus -156.34, 159.86 58.05, 51.28 -90.68, 168.57 45.43, 79.18 -80.79, 77.37 out-out out 15.5246 Saltbr-out 16.4826 HRD-in -82.47, -42.11 70.94, -10.4 out-out-out SNCooo out-out ActLoopNT-out 9.4447 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -71.13, -44.57 APE9-dihe-na 100.23, 100.79 APE8-dihe-out -96.55, -49.37 APE8-rot-out 61.77 APE67-dihe-out -125.36, 134.49 -112.13, 139.3 APE12-dist-out 16.7317 APE11-dist-out 18.0625 APE10-dist-out 22.9269 APE9-dist-out 12.6232 S218A,S222A None None EM 4.16 999.0 999.0 B 394.0 278.0 51 26 26 0 [[68, 361]] 1.0 9axc Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9AXCD Q02750 59 383 393.0 A1AHE:401 Type3 Inactive DFGin 5.9443 14.9428 BLBplus -155.71, -173.77 60.85, 40.35 -100.84, 165.38 63.0, 90.55 -83.19, 80.54 out-out out 17.464 Saltbr-out 19.8823 HRD-in -94.68, -47.55 72.62, -11.59 out-out-out SNCooo out-out ActLoopNT-out 9.3746 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na 51.94, -88.31 APE9-dihe-na 51.11, 70.23 APE8-dihe-out -66.0, -35.69 APE8-rot-in 292.49 APE67-dihe-out -158.48, 126.03 -105.47, -179.54 APE12-dist-out 18.7745 APE11-dist-out 17.0622 APE10-dist-out 21.141 APE9-dist-out 12.4403 S218A,S222A None None EM 4.16 999.0 999.0 D 394.0 275.0 50 26 26 0 [[68, 361]] 1.0 9axc Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9O0UD Q02750 31 380 393.0 CHU:401 Type3 Inactive DFGin 6.2577 14.2452 BLBplus -155.2, 170.07 62.24, 48.49 -103.46, 163.38 44.86, 81.23 -80.64, 82.9 out-out out 15.8042 Saltbr-out 15.5601 HRD-in -72.61, -47.48 72.0, -5.51 out-out-out SNCooo out-out ActLoopNT-out 9.507 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -145.99, 151.57 APE9-dihe-na -129.02, 151.01 APE8-dihe-out -101.49, -25.69 APE8-rot-in 295.14 APE67-dihe-out -149.54, 133.77 -134.81, 174.59 APE12-dist-out 17.407 APE11-dist-out 17.5585 APE10-dist-out 22.6481 APE9-dist-out 12.7538 S218A,S222A None None XRAY 2.91 0.232 0.264 D 395.0 317.0 33 26 26 0 [[68, 361]] 1.0 9o0u Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9O0UF Q02750 30 380 393.0 CHU:401 Type3 Inactive DFGin 6.24 14.2415 BLBplus -149.4, 162.55 67.26, 47.9 -103.2, 163.92 46.52, 88.85 -79.29, 85.22 out-out out 15.5394 Saltbr-out 16.2358 HRD-in -74.73, -46.69 72.92, -6.37 out-out-out SNCooo out-out ActLoopNT-out 9.8344 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -124.83, 125.43 APE9-dihe-na -156.49, 116.77 APE8-dihe-out -98.23, -8.63 APE8-rot-in 320.21 APE67-dihe-out -147.81, 133.84 -133.15, 172.65 APE12-dist-out 18.6641 APE11-dist-out 16.7859 APE10-dist-out 21.1732 APE9-dist-out 12.5375 S218A,S222A None None XRAY 2.91 0.232 0.264 F 395.0 322.0 29 26 26 0 [[68, 361]] 1.0 9o0u Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 4AN2A Q02750 61 381 393.0 EUI:61382,ACP:61383 Type3,ATPlike Inactive DFGin 6.5059 13.6203 BLBplus -122.79, 178.99 56.84, 40.15 -92.39, 167.6 39.23, 93.66 -89.21, 72.99 out-out out 15.4473 Saltbr-out 15.2762 HRD-in -67.56, -54.42 79.08, -11.1 out-out-out SNCooo out-out ActLoopNT-out 9.0354 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -98.27, 63.09 APE9-dihe-na -45.72, -71.67 APE8-dihe-in -89.8, 67.42 APE8-rot-out 5.41 APE67-dihe-in -66.45, -14.82 -49.39, -42.64 APE12-dist-out 17.4744 APE11-dist-out 16.5588 APE10-dist-out 17.0301 APE9-dist-out 8.7163 S218E,S222E,G328A None None XRAY 2.5 0.215 0.299 A 301.0 279.0 0 26 26 0 [[68, 361]] 1.0 4an2 Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 4ANBA Q02750 61 381 393.0 YQY:60501,ACP:60502 Type3,ATPlike Inactive DFGin 6.3584 13.3927 BLBplus -107.54, 172.13 64.32, 39.17 -93.81, 160.33 38.34, 94.07 -83.38, 74.0 out-out out 15.2238 Saltbr-out 14.8172 HRD-in -75.33, -47.65 77.84, -16.31 out-out-out SNCooo out-out ActLoopNT-out 9.4144 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -89.14, -39.83 APE9-dihe-na 89.67, -158.68 APE8-dihe-in -87.88, 72.09 APE8-rot-out 15.75 APE67-dihe-in -64.72, -18.82 -69.34, -22.58 APE12-dist-out 17.552 APE11-dist-out 16.8932 APE10-dist-out 19.8413 APE9-dist-out 8.65 S218E,S222E,G328A None None XRAY 2.2 0.23 0.296 A 301.0 279.0 0 26 26 0 [[68, 361]] 1.0 4anb Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 2P55A Q02750 62 382 393.0 MRA:69000,ATP:69001 Type3,ATPlike Inactive DFGin 6.1626 13.3824 BLBplus -134.23, -173.95 50.87, 43.67 -95.4, 166.24 42.0, 89.87 -87.86, 76.42 out-out out 15.2177 Saltbr-out 15.3456 HRD-in -70.81, -55.41 89.6, -22.02 out-out-out SNCooo out-out ActLoopNT-out 9.468 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -78.03 APE9-dihe-na 94.66, -135.55 APE8-dihe-out -131.47, -8.61 APE8-rot-out 200.5 APE67-dihe-out -121.47, 132.61 -102.76, 124.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.1744 APE9-dist-out 13.9789 None None None XRAY 2.8 0.228 0.301 A 333.0 288.0 33 26 23 3 [[68, 361]] 1.0 2p55 Homo sapiens STE_MAP2K1_HUMAN STE 1.4e-97 332.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 4U7ZA Q02750 62 382 393.0 3EW:60502,ANP:60503 Type3,ATPlike Inactive DFGin 6.2159 13.6689 BLBplus -143.34, -175.79 52.44, 38.8 -93.27, 161.31 44.21, 87.69 -81.82, 73.69 out-out out 15.3339 Saltbr-out 16.1402 HRD-in -66.47, -61.07 88.23, -17.21 out-out-out SNCooo out-out ActLoopNT-out 9.1989 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_onoo APE10-dihe-na 999.0, -56.79 APE9-dihe-na 112.87, -133.38 APE8-dihe-out -132.3, 18.52 APE8-rot-out 53.52 APE67-dihe-out -108.34, 133.35 -145.71, 114.06 APE12-dist-out 17.9335 APE11-dist-none 999.0 APE10-dist-out 19.6013 APE9-dist-out 13.9529 None None None XRAY 2.805 0.163 0.214 A 341.0 290.0 31 26 25 1 [[68, 361]] 1.0 4u7z Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 4U81A Q02750 62 382 393.0 3EY:60502,ANP:60503 Type3,ATPlike Inactive DFGin 6.3677 13.5745 BLBplus -142.15, -179.17 57.69, 35.98 -93.9, 164.88 44.15, 86.95 -87.34, 72.9 out-out out 15.2755 Saltbr-out 15.4161 HRD-in -63.27, -55.06 80.23, -11.72 out-out-out SNCooo out-out ActLoopNT-out 9.3239 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -28.47 APE9-dihe-na 110.81, -177.13 APE8-dihe-out -114.66, 19.88 APE8-rot-out 189.5 APE67-dihe-out -109.38, 142.31 -159.49, 131.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.6841 APE9-dist-out 12.9691 None None None XRAY 2.701 0.169 0.218 A 341.0 288.0 33 26 23 3 [[68, 361]] 1.0 4u81 Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3V01A Q02750 62 382 393.0 3V0:60501,ATP:60502 Type3,ATPlike Inactive DFGin 6.105 13.4244 BLBplus -142.06, -173.42 54.59, 34.91 -91.82, 163.8 47.01, 90.27 -88.09, 75.03 out-out out 15.5642 Saltbr-out 15.7785 HRD-in -62.64, -63.68 88.6, -7.02 out-out-out SNCooo out-out ActLoopNT-out 9.2768 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -67.65 APE9-dihe-na 102.3, -166.23 APE8-dihe-out -116.29, 3.8 APE8-rot-out 189.24 APE67-dihe-out -108.4, 130.42 -142.07, 120.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.0771 APE9-dist-out 12.8379 None None None XRAY 2.705 0.189 0.24 A 341.0 288.0 33 26 23 3 [[68, 361]] 1.0 3v01 Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3V04A Q02750 62 382 393.0 V04:60501,ATP:60502 Type3,ATPlike Inactive DFGin 6.2019 13.4656 BLBplus -139.99, -177.53 54.26, 36.29 -92.6, 163.3 43.17, 90.4 -92.7, 75.2 out-out out 15.6131 Saltbr-out 16.0488 HRD-in -56.82, -58.2 81.63, -6.31 out-out-out SNCooo out-out ActLoopNT-out 9.1096 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -43.92 APE9-dihe-na 143.86, 160.52 APE8-dihe-out -85.24, -10.44 APE8-rot-out 182.43 APE67-dihe-out -103.47, 130.39 -134.15, 117.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.8085 APE9-dist-out 12.649 None None None XRAY 2.7 0.213 0.243 A 341.0 288.0 33 26 23 3 [[68, 361]] 1.0 3v04 Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3EQCA Q02750 39 382 393.0 3BM:1,AGS:2 Type3,ATPlike Inactive DFGin 6.1057 13.8617 BLBplus -138.12, -177.12 54.65, 30.92 -83.74, 156.51 44.84, 87.16 -79.52, 70.22 out-out out 15.3111 Saltbr-out 14.7046 HRD-in -64.92, -56.9 85.6, -17.06 out-out-out SNCooo out-out ActLoopNT-out 9.3671 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 106.4 APE9-dihe-na -87.03, 145.5 APE8-dihe-in -52.92, 140.89 APE8-rot-out 198.88 APE67-dihe-in -66.8, -13.13 -101.4, 5.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.4624 APE9-dist-out 9.4427 S298N,S299K,Y300F None None XRAY 1.8 0.201 0.235 A 360.0 312.0 32 26 23 3 [[68, 361]] 1.0 3eqc Homo sapiens STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3EQHA Q02750 39 381 393.0 5BM:1,ADP:2 Type3,ATPlike Inactive DFGin 6.8455 13.3483 BLBplus -141.56, 168.5 59.76, 36.07 -79.95, 154.58 28.74, 98.71 -78.77, 88.92 out-out out 15.2501 Saltbr-out 13.9257 HRD-in -70.86, -51.49 82.66, -16.34 out-out-out SNCooo out-out ActLoopNT-out 9.8448 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na 72.18, 69.91 APE9-dihe-na -156.93, 105.03 APE8-dihe-in -35.31, 137.66 APE8-rot-out 209.36 APE67-dihe-in -58.22, -17.3 -105.41, 1.3 APE12-dist-out 17.8887 APE11-dist-out 18.0239 APE10-dist-out 19.2755 APE9-dist-out 9.6547 S298N,S299K,Y300F None None XRAY 2.0 0.192 999.0 A 360.0 314.0 29 26 26 0 [[68, 361]] 1.0 3eqh Homo sapiens STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9ECUB Q02750 43 383 393.0 A1BIS:401,ANP:402 Type3,ATPlike Inactive DFGin 5.9391 13.7784 BLBplus -142.06, 162.17 53.85, 47.21 -95.43, 152.31 51.94, 84.92 -79.97, 96.68 out-out out 15.5116 Saltbr-out 16.1296 HRD-in -66.75, -57.05 86.44, -9.92 out-out-out SNCooo out-out ActLoopNT-out 9.377 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -121.25, 157.88 APE9-dihe-na -135.0, 168.26 APE8-dihe-out -68.75, -42.35 APE8-rot-in 291.8 APE67-dihe-out -146.65, 140.6 -150.67, 174.43 APE12-dist-out 21.121 APE11-dist-out 17.8937 APE10-dist-out 23.1346 APE9-dist-out 13.6562 None None None XRAY 3.46 0.202 0.237 B 393.0 309.0 32 26 26 0 [[68, 361]] 1.0 9ecu Homo sapiens STE_MAP2K1_HUMAN STE 2.4e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9AXYB Q02750 40 383 393.0 A1AHE:401,ANP:402 Type3,ATPlike Inactive DFGin 5.9383 14.1345 BLBplus -149.11, 165.49 51.9, 40.29 -92.3, 159.5 54.58, 76.32 -75.9, 70.87 out-out out 15.3992 Saltbr-out 14.9875 HRD-in -57.0, -47.47 79.88, -10.87 out-out-out SNCooo out-out ActLoopNT-out 9.3372 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -115.09, 128.49 APE9-dihe-na -79.18, 173.05 APE8-dihe-out -111.11, -19.81 APE8-rot-out 47.95 APE67-dihe-out -148.5, 141.81 -130.51, 175.5 APE12-dist-out 18.1758 APE11-dist-out 19.7311 APE10-dist-out 22.7854 APE9-dist-out 13.2287 S218A,S222A None None XRAY 3.6 0.19 0.237 B 394.0 312.0 32 26 26 0 [[68, 361]] 1.0 9axy Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9O0VD Q02750 31 380 393.0 CHU:401,ANP:402 Type3,ATPlike Inactive DFGin 6.3733 14.325 BLBplus -154.54, 169.16 62.18, 48.49 -103.44, 163.24 44.6, 81.5 -80.27, 83.26 out-out out 16.0835 Saltbr-out 14.6053 HRD-in -72.92, -47.49 72.01, -5.54 out-out-out SNCooo out-out ActLoopNT-out 9.4975 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -145.24, 151.58 APE9-dihe-na -129.14, 150.7 APE8-dihe-out -101.27, -25.48 APE8-rot-in 295.39 APE67-dihe-out -149.5, 133.8 -134.87, 174.51 APE12-dist-out 17.6813 APE11-dist-out 17.5865 APE10-dist-out 22.6132 APE9-dist-out 12.7344 S218A,S222A None None XRAY 3.5 0.208 0.254 D 395.0 315.0 35 26 26 0 [[68, 361]] 1.0 9o0v Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 9O0VF Q02750 30 380 393.0 CHU:401,ANP:402 Type3,ATPlike Inactive DFGin 6.3482 14.2973 BLBplus -150.02, 162.92 66.4, 48.22 -102.89, 163.79 46.62, 89.05 -79.32, 84.9 out-out out 15.5104 Saltbr-out 15.8816 HRD-in -75.24, -46.98 72.8, -6.4 out-out-out SNCooo out-out ActLoopNT-out 9.801 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -127.4, 126.99 APE9-dihe-na -155.92, 117.08 APE8-dihe-out -98.23, -9.95 APE8-rot-in 320.72 APE67-dihe-out -148.49, 134.6 -133.67, 172.28 APE12-dist-out 18.6736 APE11-dist-out 16.7401 APE10-dist-out 21.3436 APE9-dist-out 12.7026 S218A,S222A None None XRAY 3.5 0.208 0.254 F 395.0 322.0 29 26 26 0 [[68, 361]] 1.0 9o0v Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7M0TB Q02750 42 383 393.0 3EW:401,ANP:402 Type3,ATPlike Inactive DFGin 6.0753 13.7095 BLBplus -159.9, -178.5 64.02, 41.63 -104.3, 143.17 46.34, 100.82 -64.54, 70.24 out-out out 15.4777 Saltbr-out 16.3323 HRD-in -53.73, -55.69 69.68, 5.22 out-out-out SNCooo out-out ActLoopNT-out 8.8715 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -40.91, 141.26 APE9-dihe-na -101.18, -177.28 APE8-dihe-out -68.44, -50.32 APE8-rot-in 321.79 APE67-dihe-out -148.38, 132.66 -145.97, 175.15 APE12-dist-out 17.1657 APE11-dist-out 22.6476 APE10-dist-out 23.7095 APE9-dist-out 13.8641 S218A,S222A None None XRAY 3.19 0.199 0.254 B 397.0 310.0 32 26 26 0 [[68, 361]] 1.0 7m0t Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7M0UB Q02750 43 385 393.0 QO7:501,ANP:502 Type3,ATPlike Inactive DFGin 6.1782 13.8403 BLBplus -152.87, -177.82 54.02, 43.66 -96.33, 148.45 42.9, 86.91 -71.94, 82.66 out-out out 15.4928 Saltbr-out 15.6637 HRD-in -60.41, -57.85 71.46, -3.21 out-out-out SNCooo out-out ActLoopNT-out 9.0481 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -60.78, 138.09 APE9-dihe-na -86.76, -175.69 APE8-dihe-out -100.26, -15.57 APE8-rot-out 49.06 APE67-dihe-out -118.78, 147.11 -163.65, 150.46 APE12-dist-out 17.2011 APE11-dist-out 22.3588 APE10-dist-out 23.5662 APE9-dist-out 13.6379 S218A,S222A None None XRAY 3.09 0.193 0.23 B 397.0 311.0 32 26 26 0 [[68, 361]] 1.0 7m0u Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 5YT3B Q02750 40 382 393.0 ANP:401 ATPlike Inactive DFGin 5.8963 14.534 None -102.15, -169.78 -40.15, 149.52 -75.91, 143.56 303.08, 84.8 -64.88, 94.03 out-out out 16.3586 Saltbr-out 14.8656 HRD-out -104.42, 23.77 -144.46, 111.13 out-out-out SNCooo out-out ActLoopNT-out 8.0209 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -80.58, -32.09 APE9-dihe-na -86.11, -15.83 APE8-dihe-out 58.15, 64.44 APE8-rot-in 310.76 APE67-dihe-out -122.56, 143.11 -138.66, 139.98 APE12-dist-out 19.0552 APE11-dist-out 14.0554 APE10-dist-out 18.8403 APE9-dist-out 25.9099 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 B 350.0 311.0 32 26 26 0 [[68, 361]] 1.0 5yt3 Homo sapiens STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 5YT3D Q02750 39 382 393.0 ANP:401 ATPlike Inactive DFGin 5.7501 14.7176 None -77.53, 172.31 -71.81, 159.92 -66.82, 141.72 314.31, 87.77 -59.96, 135.61 out-out out 16.8715 Saltbr-out 15.0058 HRD-out -106.97, -11.01 -97.02, 107.72 out-out-out SNCooo out-out ActLoopNT-out 8.2442 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -63.82, -51.0 APE9-dihe-na -70.37, -13.35 APE8-dihe-out 47.35, 74.88 APE8-rot-out 143.99 APE67-dihe-out -134.73, 126.26 -143.64, 140.67 APE12-dist-out 19.3394 APE11-dist-out 14.3822 APE10-dist-out 19.1547 APE9-dist-out 26.1684 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 D 350.0 309.0 35 26 26 0 [[68, 361]] 1.0 5yt3 Homo sapiens STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 8YP4A Q02750 34 384 393.0 WNT:401 Type1 Inactive DFGin 5.6499 12.5748 None -114.29, -33.59 -28.46, 108.03 -125.65, 141.38 278.55, 110.59 -62.12, 167.08 out-out out 15.0636 Saltbr-out 17.0816 HRD-out 70.59, -102.97 160.56, -67.88 out-out-out SNCooo out-out ActLoopNT-out 13.7522 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, 77.83 APE9-dihe-na -121.62, 81.96 APE8-dihe-out 101.02, -24.75 APE8-rot-in 322.27 APE67-dihe-out -132.46, 136.61 -111.44, 133.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.1822 APE9-dist-out 15.9962 T286A,T292A,S298A None None XRAY 2.35 0.21 0.284 A 365.0 305.0 46 26 17 9 [[68, 361]] 1.0 8yp4 Homo sapiens STE_MAP2K1_HUMAN STE 1.9e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 5YT3A Q02750 39 382 393.0 ANP:401 ATPlike Inactive DFGinter 6.3567 10.3827 None -128.68, 173.26 63.68, 38.66 -52.93, -21.76 28.6, 36.22 -61.84, 114.84 out-out out 16.3153 Saltbr-out 14.589 HRD-in -77.7, -42.23 58.41, 13.61 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 70.97 APE8-rot-none 999.0 APE67-dihe-out -132.4, 139.8 -149.07, 91.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 A 350.0 297.0 47 26 12 14 [[68, 361]] 1.0 5yt3 Homo sapiens STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 5HZEA Q02750 43 382 393.0 E62:401 Type1 Inactive DFGout 13.1327 7.9841 None -116.15, 117.25 -152.6, 137.8 -122.31, 13.73 47.76, 105.92 -84.87, 19.19 out-out out 15.2588 Saltbr-out 14.5791 HRD-none 999.0, 999.0 999.0, 171.7 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -139.21, 125.62 APE9-dihe-na -55.02, 151.61 APE8-dihe-in -60.96, 141.55 APE8-rot-out 186.19 APE67-dihe-in -73.9, -3.69 -95.68, 3.3 APE12-dist-out 18.0199 APE11-dist-out 17.7496 APE10-dist-out 16.6379 APE9-dist-out 10.6787 S298N,S299K,Y300F None None XRAY 2.4 0.205 0.287 A 348.0 305.0 35 26 26 0 [[68, 361]] 1.0 5hze Homo sapiens STE_MAP2K1_HUMAN STE 1.6e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 8YP4B Q02750 43 383 393.0 WNT:402 Type1 Inactive DFGout 11.3253 6.4247 None -108.9, 111.79 -94.09, -121.26 66.37, 140.13 107.59, 69.46 128.79, 15.36 out-out out 15.3476 Saltbr-out 16.193 HRD-out 49.23, 166.44 96.35, 147.86 out-out-out SNCooo out-out ActLoopNT-out 11.7919 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -125.63 APE8-rot-out 65.35 APE67-dihe-out 121.59, -95.83 78.91, 128.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T286A,T292A,S298A None None XRAY 2.35 0.21 0.284 B 365.0 299.0 42 26 15 11 [[68, 361]] 1.0 8yp4 Homo sapiens STE_MAP2K1_HUMAN STE 1.9e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 7F2XA Q02750 45 382 393.0 ANP:60501 ATPlike Inactive None 14.5783 16.4961 None -71.03, 160.3 -74.32, 105.83 -69.14, -7.13 285.96, 1.01 -79.69, -8.9 out-out out 16.3606 Saltbr-out 16.8732 HRD-out -123.25, -2.01 -136.26, 151.99 out-out-out SNCooo out-out ActLoopNT-out 10.3746 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -84.56, -47.24 APE9-dihe-na 151.04, 109.57 APE8-dihe-in -68.48, 129.23 APE8-rot-in 304.12 APE67-dihe-out -103.66, 129.16 -127.47, 104.31 APE12-dist-out 14.4563 APE11-dist-out 17.6728 APE10-dist-out 20.3077 APE9-dist-out 25.5229 None None None XRAY 2.007 0.216 0.232 A 321.0 300.0 0 26 26 0 [[68, 361]] 1.0 7f2x Homo sapiens STE_MAP2K1_HUMAN STE 1.4e-97 332.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 3W8QA Q02750 39 382 393.0 AGS:401 ATPlike Inactive None 13.1078 15.1223 None -61.95, 160.72 -84.08, 71.5 -96.94, 162.22 62.16, 97.76 71.69, 28.05 out-out out 16.278 Saltbr-out 14.58 HRD-out -76.9, 112.47 -115.43, 103.34 out-out-out SNCooo out-out ActLoopNT-out 11.4785 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -85.42, 139.56 APE9-dihe-na 64.92, 170.12 APE8-dihe-in -109.26, 128.33 APE8-rot-out 42.71 APE67-dihe-out -157.09, 132.41 -146.54, 166.67 APE12-dist-out 15.6567 APE11-dist-out 20.9119 APE10-dist-out 24.1063 APE9-dist-out 32.1107 T292A,S298A None None XRAY 2.2 0.201 0.268 A 350.0 318.0 26 26 26 0 [[68, 361]] 1.0 3w8q Homo sapiens STE_MAP2K1_HUMAN STE 1.6e-97 331.8 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 6Q0TC Q02750 43 379 393.0 LCJ:60402,AGS:60403 Type1,ATPlike Inactive None 999.0 999.0 None -140.61, 176.69 54.64, 28.33 -81.67, 161.61 999.0, 999.0 -81.74, 73.01 out-none out 15.4983 Saltbr-none 999.0 HRD-in -63.91, -56.51 90.24, -35.06 none-out-out SNCnoo out-out ActLoopNT-out 9.2901 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oooo APE10-dihe-na -73.68, 137.65 APE9-dihe-na -84.71, 179.02 APE8-dihe-out -112.93, -24.43 APE8-rot-none 999.0 APE67-dihe-out -153.47, 146.62 -142.35, -172.44 APE12-dist-out 17.1555 APE11-dist-out 21.6524 APE10-dist-out 23.7974 APE9-dist-out 13.4988 S218A,S222A None None EM 5.7 999.0 999.0 C 414.0 306.0 31 26 26 0 [[68, 361]] 1.0 6q0t Homo sapiens STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 6Q0JC Q02750 43 379 393.0 LCJ:60402,AGS:60403 Type1,ATPlike Inactive None 999.0 999.0 None -140.59, 176.71 54.64, 28.27 -81.59, 161.59 999.0, 999.0 -81.72, 72.97 out-none out 15.4979 Saltbr-none 999.0 HRD-in -63.96, -56.51 90.23, -35.02 none-out-out SNCnoo out-out ActLoopNT-out 9.2895 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oooo APE10-dihe-na -73.68, 137.68 APE9-dihe-na -84.7, 179.01 APE8-dihe-out -112.95, -24.41 APE8-rot-none 999.0 APE67-dihe-out -153.48, 146.63 -142.35, -172.44 APE12-dist-out 17.1558 APE11-dist-out 21.6526 APE10-dist-out 23.7977 APE9-dist-out 13.4984 S218A,S222A None None EM 4.9 999.0 999.0 C 415.0 306.0 31 26 26 0 [[68, 361]] 1.0 6q0j Homo sapiens STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_HUMAN 6Q0JD Q02750 43 379 393.0 LCJ:60402,AGS:60403 Type1,ATPlike Inactive None 999.0 999.0 None -140.57, 176.69 54.62, 28.33 -81.6, 161.59 999.0, 999.0 -81.66, 72.9 out-none out 15.4977 Saltbr-none 999.0 HRD-in -63.9, -56.54 90.23, -35.02 none-out-out SNCnoo out-out ActLoopNT-out 9.2893 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oooo APE10-dihe-na -73.75, 137.67 APE9-dihe-na -84.68, 179.02 APE8-dihe-out -112.95, -24.44 APE8-rot-none 999.0 APE67-dihe-out -153.47, 146.64 -142.36, -172.48 APE12-dist-out 17.1558 APE11-dist-out 21.6536 APE10-dist-out 23.7977 APE9-dist-out 13.4991 S218A,S222A None None EM 4.9 999.0 999.0 D 415.0 306.0 31 26 26 0 [[68, 361]] 1.0 6q0j Homo sapiens STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JUQC P29678 40 381 393.0 ADP:401 ATPlike Inactive DFGin 6.5861 14.742 BLBplus -129.84, -170.1 45.36, 32.9 -86.02, 164.53 43.64, 99.66 -81.97, 72.94 out-out out 15.5727 Saltbr-out 14.6393 HRD-in -71.73, -54.6 83.98, -10.27 out-out-out SNCooo out-out ActLoopNT-out 9.8167 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -103.97, 121.68 APE9-dihe-na -107.28, -138.86 APE8-dihe-out -101.2, -25.18 APE8-rot-out 36.43 APE67-dihe-out -125.05, 133.16 -97.84, 131.49 APE12-dist-out 16.4657 APE11-dist-out 18.834 APE10-dist-out 20.472 APE9-dist-out 14.6884 None None None XRAY 3.22 0.256 0.288 C 384.0 305.0 37 26 26 0 [[68, 361]] 1.0 7juq Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JUWC P29678 40 382 393.0 ANP:401 ATPlike Inactive DFGin 5.4761 13.4814 BLBplus -119.08, 163.59 62.65, 35.07 -73.68, 154.5 52.17, 104.28 -73.77, 81.69 out-out out 15.4699 Saltbr-out 15.9777 HRD-in -78.46, -50.39 75.67, -1.62 out-out-out SNCooo out-out ActLoopNT-out 9.0937 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -134.09, 125.81 APE9-dihe-na -89.61, -160.68 APE8-dihe-out -92.22, -18.15 APE8-rot-out 194.93 APE67-dihe-out -134.04, 131.23 -117.23, 164.93 APE12-dist-out 17.3483 APE11-dist-out 16.6141 APE10-dist-out 20.5819 APE9-dist-out 12.6092 None None None XRAY 2.88 0.245 0.286 C 384.0 311.0 32 26 26 0 [[68, 361]] 1.0 7juw Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 2Y4IC P29678 37 381 393.0 ATP:1382 ATPlike Inactive DFGin 6.1966 13.7557 BLBplus -151.54, -176.33 53.75, 29.39 -91.07, 130.43 56.39, 97.48 -61.44, 113.3 out-out out 16.1319 Saltbr-out 15.7942 HRD-in -53.6, -47.94 74.29, -22.1 out-out-out SNCooo out-out ActLoopNT-out 9.9 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -108.6, -60.21 APE9-dihe-na 86.78, -165.04 APE8-dihe-out -116.15, -0.77 APE8-rot-out 172.84 APE67-dihe-out -107.13, 167.3 -126.53, 122.47 APE12-dist-out 16.2589 APE11-dist-out 19.1611 APE10-dist-out 21.2782 APE9-dist-out 14.8665 None None None XRAY 3.46 0.233 0.293 C 395.0 313.0 32 26 26 0 [[68, 361]] 1.0 2y4i Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.5e-97 331.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JURC P29678 41 381 393.0 ANP:401,QOM:402 ATPlike,Type1 Inactive DFGin 6.613 14.002 BLBplus -156.22, 177.66 63.23, 45.15 -109.91, 167.01 49.79, 96.28 -84.59, 94.82 out-out out 15.2731 Saltbr-out 15.8781 HRD-in -66.44, -49.39 76.73, -8.84 out-out-out SNCooo out-out ActLoopNT-out 9.5088 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -118.97, 111.39 APE9-dihe-na -105.66, -145.56 APE8-dihe-out -103.38, -4.62 APE8-rot-out 47.7 APE67-dihe-out -108.36, 139.88 -114.51, 107.19 APE12-dist-out 17.0478 APE11-dist-out 19.9859 APE10-dist-out 22.0123 APE9-dist-out 15.1448 None None None XRAY 2.82 0.237 0.277 C 384.0 304.0 37 26 26 0 [[68, 361]] 1.0 7jur Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JUTC P29678 41 380 393.0 ANP:401,3EW:402 ATPlike,Type3 Inactive DFGin 6.0671 13.9401 BLBplus -133.84, -178.36 52.69, 31.27 -86.2, 157.2 55.82, 93.16 -83.8, 97.49 out-out out 15.809 Saltbr-out 15.0751 HRD-in -69.63, -49.75 78.05, -10.01 out-out-out SNCooo out-out ActLoopNT-out 9.5518 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.95, 117.74 APE9-dihe-na -110.82, -149.07 APE8-dihe-out -94.42, -11.28 APE8-rot-out 36.3 APE67-dihe-out -120.05, 132.49 -111.03, 116.45 APE12-dist-out 17.2399 APE11-dist-out 19.8243 APE10-dist-out 21.7513 APE9-dist-out 14.8236 None None None XRAY 3.09 0.259 0.3 C 384.0 303.0 37 26 26 0 [[68, 361]] 1.0 7jut Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JUUC P29678 43 381 393.0 ANP:401,4BM:402 ATPlike,Type3 Inactive DFGin 6.5736 14.0084 BLBplus -143.65, 177.32 57.69, 37.46 -92.33, 152.26 41.94, 94.89 -75.77, 92.54 out-out out 15.833 Saltbr-out 14.7395 HRD-in -70.37, -49.34 74.88, -6.99 out-out-out SNCooo out-out ActLoopNT-out 9.3359 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -102.48, 121.01 APE9-dihe-na -118.18, -151.72 APE8-dihe-out -92.91, -15.39 APE8-rot-out 41.03 APE67-dihe-out -126.24, 128.64 -103.62, 122.66 APE12-dist-out 16.8116 APE11-dist-out 19.5747 APE10-dist-out 21.4997 APE9-dist-out 14.8147 None None None XRAY 3.19 0.242 0.258 C 384.0 302.0 37 26 26 0 [[68, 361]] 1.0 7juu Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JUVC P29678 41 381 393.0 ANP:401,VKG:402 ATPlike,Type3 Inactive DFGin 6.2421 14.0185 BLBplus -157.56, 157.79 64.55, 38.6 -93.84, 164.37 42.83, 100.3 -83.58, 81.75 out-out out 16.0313 Saltbr-out 15.4096 HRD-in -64.23, -51.09 77.84, -3.99 out-out-out SNCooo out-out ActLoopNT-out 9.291 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -121.06, 123.07 APE9-dihe-na -111.51, -147.21 APE8-dihe-out -99.25, -5.79 APE8-rot-out 47.73 APE67-dihe-out -106.23, 137.61 -113.69, 113.69 APE12-dist-out 16.9686 APE11-dist-out 20.03 APE10-dist-out 21.6139 APE9-dist-out 15.1297 None None None XRAY 3.36 0.242 0.255 C 384.0 304.0 37 26 26 0 [[68, 361]] 1.0 7juv Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JUXC P29678 40 381 393.0 ANP:401,QOM:402 ATPlike,Type3 Inactive DFGin 6.4278 14.3556 BLBplus -129.48, -171.66 44.07, 32.82 -84.98, 164.12 41.6, 98.75 -82.14, 71.95 out-out out 17.5863 Saltbr-out 20.1916 HRD-in -72.38, -56.06 82.77, -10.45 out-out-out SNCooo out-out ActLoopNT-out 9.1972 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -105.79, 149.07 APE9-dihe-na -128.12, -140.49 APE8-dihe-out -102.97, -28.75 APE8-rot-out 180.26 APE67-dihe-out -123.35, 132.01 -101.05, 135.7 APE12-dist-out 15.9606 APE11-dist-out 18.6447 APE10-dist-out 21.1274 APE9-dist-out 13.9765 None None None XRAY 3.34 0.265 0.283 C 384.0 308.0 34 26 26 0 [[68, 361]] 1.0 7jux Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JUYC P29678 40 382 393.0 ANP:401,EUI:402 ATPlike,Type3 Inactive DFGin 5.8023 13.9446 BLBplus -119.74, 162.94 62.38, 34.15 -75.02, 153.8 53.17, 104.23 -74.72, 81.57 out-out out 15.6895 Saltbr-out 15.7759 HRD-in -78.99, -50.85 75.95, -2.2 out-out-out SNCooo out-out ActLoopNT-out 8.6396 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -134.38, 125.81 APE9-dihe-na -89.68, -160.4 APE8-dihe-out -91.9, -17.82 APE8-rot-out 194.83 APE67-dihe-out -134.16, 130.72 -117.22, 165.02 APE12-dist-out 17.5274 APE11-dist-out 16.8292 APE10-dist-out 20.535 APE9-dist-out 12.5725 None None None XRAY 3.096 0.248 0.257 C 384.0 311.0 32 26 26 0 [[68, 361]] 1.0 7juy Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JUZC P29678 40 382 393.0 ANP:401,3EW:402 ATPlike,Type3 Inactive DFGin 5.9412 14.2448 BLBplus -127.35, 173.99 64.59, 36.11 -89.55, 153.11 55.39, 95.23 -79.11, 95.72 out-out out 16.8967 Saltbr-out 15.3901 HRD-in -78.66, -56.19 75.89, -1.31 out-out-out SNCooo out-out ActLoopNT-out 8.8285 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.68, 119.69 APE9-dihe-na -83.26, -173.5 APE8-dihe-out -76.47, -20.99 APE8-rot-out 195.18 APE67-dihe-out -133.01, 129.38 -114.64, 162.26 APE12-dist-out 17.257 APE11-dist-out 16.6053 APE10-dist-out 20.4548 APE9-dist-out 12.4227 None None None XRAY 3.21 0.255 0.272 C 384.0 308.0 35 26 26 0 [[68, 361]] 1.0 7juz Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JV0C P29678 40 382 393.0 ANP:401,4BM:402 ATPlike,Type3 Inactive DFGin 5.8727 14.2702 BLBplus -118.46, 167.04 65.91, 31.94 -77.55, 158.19 54.28, 101.68 -82.73, 82.06 out-out out 16.4454 Saltbr-out 16.8702 HRD-in -78.95, -48.37 72.45, 0.0 out-out-out SNCooo out-out ActLoopNT-out 8.9767 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -134.69, 127.82 APE9-dihe-na -92.23, -161.01 APE8-dihe-out -91.79, -17.2 APE8-rot-out 194.87 APE67-dihe-out -131.33, 129.9 -118.91, 161.4 APE12-dist-out 17.5672 APE11-dist-out 16.9191 APE10-dist-out 20.7981 APE9-dist-out 12.6788 None None None XRAY 3.63 0.247 0.26 C 384.0 308.0 35 26 26 0 [[68, 361]] 1.0 7jv0 Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JV1C P29678 40 381 393.0 ANP:401,VKG:402 ATPlike,Type3 Inactive DFGin 6.4027 13.987 BLBplus -129.45, -171.63 44.64, 33.58 -84.88, 163.88 41.4, 98.6 -82.69, 72.31 out-out out 17.7833 Saltbr-out 17.8868 HRD-in -72.64, -55.74 83.07, -10.49 out-out-out SNCooo out-out ActLoopNT-out 9.5186 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.03, 153.74 APE9-dihe-na -129.76, -140.43 APE8-dihe-out -102.55, -29.44 APE8-rot-out 180.23 APE67-dihe-out -122.99, 132.28 -101.94, 135.93 APE12-dist-out 15.759 APE11-dist-out 19.0444 APE10-dist-out 21.0399 APE9-dist-out 14.1526 None None None XRAY 3.62 0.278 0.303 C 384.0 308.0 34 26 26 0 [[68, 361]] 1.0 7jv1 Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 5KKRC P29678 41 381 393.0 No_ligand No_ligand Inactive DFGin 5.6864 14.7208 BLBplus -158.86, 161.03 54.66, 76.63 -127.36, 155.38 51.94, 88.12 -65.72, 114.93 out-out out 16.7672 Saltbr-out 17.5976 HRD-in -80.0, -34.43 65.62, -12.22 out-out-out SNCooo out-out ActLoopNT-out 9.8888 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -95.67, -78.94 APE9-dihe-na 120.42, 151.43 APE8-dihe-out -85.94, -11.72 APE8-rot-out 171.08 APE67-dihe-out -107.86, 142.56 -124.16, 111.31 APE12-dist-out 16.0673 APE11-dist-out 19.7439 APE10-dist-out 21.3477 APE9-dist-out 14.2327 None None None XRAY 3.509 0.252 0.287 C 395.0 309.0 32 26 26 0 [[68, 361]] 1.0 5kkr Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.5e-97 331.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JUSC P29678 41 381 393.0 VKD:501,ANP:502 Type3,ATPlike Inactive DFGin 6.6408 14.136 BLBplus -157.57, 158.09 64.1, 38.39 -94.54, 165.57 43.42, 100.58 -82.33, 83.96 out-out out 16.4432 Saltbr-out 17.0647 HRD-in -64.72, -50.01 79.43, -5.86 out-out-out SNCooo out-out ActLoopNT-out 9.2055 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -121.8, 123.06 APE9-dihe-na -111.39, -149.55 APE8-dihe-out -101.45, -2.19 APE8-rot-out 46.64 APE67-dihe-out -107.18, 138.05 -110.5, 111.25 APE12-dist-out 16.9565 APE11-dist-out 19.7412 APE10-dist-out 21.5845 APE9-dist-out 15.1016 None None None XRAY 2.99 0.249 0.265 C 384.0 304.0 37 26 26 0 [[68, 361]] 1.0 7jus Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1

STE_MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)

Total number of chains: 14
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 14 100.0% 7JUWC
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP2K1 MP2K1_RABIT 7JUQC P29678 40 381 393.0 ADP:401 ATPlike Inactive DFGin 6.5861 14.742 BLBplus -129.84, -170.1 45.36, 32.9 -86.02, 164.53 43.64, 99.66 -81.97, 72.94 out-out out 15.5727 Saltbr-out 14.6393 HRD-in -71.73, -54.6 83.98, -10.27 out-out-out SNCooo out-out ActLoopNT-out 9.8167 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -103.97, 121.68 APE9-dihe-na -107.28, -138.86 APE8-dihe-out -101.2, -25.18 APE8-rot-out 36.43 APE67-dihe-out -125.05, 133.16 -97.84, 131.49 APE12-dist-out 16.4657 APE11-dist-out 18.834 APE10-dist-out 20.472 APE9-dist-out 14.6884 None None None XRAY 3.22 0.256 0.288 C 384.0 305.0 37 26 26 0 [[68, 361]] 1.0 7juq Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JUWC P29678 40 382 393.0 ANP:401 ATPlike Inactive DFGin 5.4761 13.4814 BLBplus -119.08, 163.59 62.65, 35.07 -73.68, 154.5 52.17, 104.28 -73.77, 81.69 out-out out 15.4699 Saltbr-out 15.9777 HRD-in -78.46, -50.39 75.67, -1.62 out-out-out SNCooo out-out ActLoopNT-out 9.0937 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -134.09, 125.81 APE9-dihe-na -89.61, -160.68 APE8-dihe-out -92.22, -18.15 APE8-rot-out 194.93 APE67-dihe-out -134.04, 131.23 -117.23, 164.93 APE12-dist-out 17.3483 APE11-dist-out 16.6141 APE10-dist-out 20.5819 APE9-dist-out 12.6092 None None None XRAY 2.88 0.245 0.286 C 384.0 311.0 32 26 26 0 [[68, 361]] 1.0 7juw Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 2Y4IC P29678 37 381 393.0 ATP:1382 ATPlike Inactive DFGin 6.1966 13.7557 BLBplus -151.54, -176.33 53.75, 29.39 -91.07, 130.43 56.39, 97.48 -61.44, 113.3 out-out out 16.1319 Saltbr-out 15.7942 HRD-in -53.6, -47.94 74.29, -22.1 out-out-out SNCooo out-out ActLoopNT-out 9.9 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -108.6, -60.21 APE9-dihe-na 86.78, -165.04 APE8-dihe-out -116.15, -0.77 APE8-rot-out 172.84 APE67-dihe-out -107.13, 167.3 -126.53, 122.47 APE12-dist-out 16.2589 APE11-dist-out 19.1611 APE10-dist-out 21.2782 APE9-dist-out 14.8665 None None None XRAY 3.46 0.233 0.293 C 395.0 313.0 32 26 26 0 [[68, 361]] 1.0 2y4i Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.5e-97 331.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JURC P29678 41 381 393.0 ANP:401,QOM:402 ATPlike,Type1 Inactive DFGin 6.613 14.002 BLBplus -156.22, 177.66 63.23, 45.15 -109.91, 167.01 49.79, 96.28 -84.59, 94.82 out-out out 15.2731 Saltbr-out 15.8781 HRD-in -66.44, -49.39 76.73, -8.84 out-out-out SNCooo out-out ActLoopNT-out 9.5088 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -118.97, 111.39 APE9-dihe-na -105.66, -145.56 APE8-dihe-out -103.38, -4.62 APE8-rot-out 47.7 APE67-dihe-out -108.36, 139.88 -114.51, 107.19 APE12-dist-out 17.0478 APE11-dist-out 19.9859 APE10-dist-out 22.0123 APE9-dist-out 15.1448 None None None XRAY 2.82 0.237 0.277 C 384.0 304.0 37 26 26 0 [[68, 361]] 1.0 7jur Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JUTC P29678 41 380 393.0 ANP:401,3EW:402 ATPlike,Type3 Inactive DFGin 6.0671 13.9401 BLBplus -133.84, -178.36 52.69, 31.27 -86.2, 157.2 55.82, 93.16 -83.8, 97.49 out-out out 15.809 Saltbr-out 15.0751 HRD-in -69.63, -49.75 78.05, -10.01 out-out-out SNCooo out-out ActLoopNT-out 9.5518 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.95, 117.74 APE9-dihe-na -110.82, -149.07 APE8-dihe-out -94.42, -11.28 APE8-rot-out 36.3 APE67-dihe-out -120.05, 132.49 -111.03, 116.45 APE12-dist-out 17.2399 APE11-dist-out 19.8243 APE10-dist-out 21.7513 APE9-dist-out 14.8236 None None None XRAY 3.09 0.259 0.3 C 384.0 303.0 37 26 26 0 [[68, 361]] 1.0 7jut Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JUUC P29678 43 381 393.0 ANP:401,4BM:402 ATPlike,Type3 Inactive DFGin 6.5736 14.0084 BLBplus -143.65, 177.32 57.69, 37.46 -92.33, 152.26 41.94, 94.89 -75.77, 92.54 out-out out 15.833 Saltbr-out 14.7395 HRD-in -70.37, -49.34 74.88, -6.99 out-out-out SNCooo out-out ActLoopNT-out 9.3359 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -102.48, 121.01 APE9-dihe-na -118.18, -151.72 APE8-dihe-out -92.91, -15.39 APE8-rot-out 41.03 APE67-dihe-out -126.24, 128.64 -103.62, 122.66 APE12-dist-out 16.8116 APE11-dist-out 19.5747 APE10-dist-out 21.4997 APE9-dist-out 14.8147 None None None XRAY 3.19 0.242 0.258 C 384.0 302.0 37 26 26 0 [[68, 361]] 1.0 7juu Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JUVC P29678 41 381 393.0 ANP:401,VKG:402 ATPlike,Type3 Inactive DFGin 6.2421 14.0185 BLBplus -157.56, 157.79 64.55, 38.6 -93.84, 164.37 42.83, 100.3 -83.58, 81.75 out-out out 16.0313 Saltbr-out 15.4096 HRD-in -64.23, -51.09 77.84, -3.99 out-out-out SNCooo out-out ActLoopNT-out 9.291 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -121.06, 123.07 APE9-dihe-na -111.51, -147.21 APE8-dihe-out -99.25, -5.79 APE8-rot-out 47.73 APE67-dihe-out -106.23, 137.61 -113.69, 113.69 APE12-dist-out 16.9686 APE11-dist-out 20.03 APE10-dist-out 21.6139 APE9-dist-out 15.1297 None None None XRAY 3.36 0.242 0.255 C 384.0 304.0 37 26 26 0 [[68, 361]] 1.0 7juv Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JUXC P29678 40 381 393.0 ANP:401,QOM:402 ATPlike,Type3 Inactive DFGin 6.4278 14.3556 BLBplus -129.48, -171.66 44.07, 32.82 -84.98, 164.12 41.6, 98.75 -82.14, 71.95 out-out out 17.5863 Saltbr-out 20.1916 HRD-in -72.38, -56.06 82.77, -10.45 out-out-out SNCooo out-out ActLoopNT-out 9.1972 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -105.79, 149.07 APE9-dihe-na -128.12, -140.49 APE8-dihe-out -102.97, -28.75 APE8-rot-out 180.26 APE67-dihe-out -123.35, 132.01 -101.05, 135.7 APE12-dist-out 15.9606 APE11-dist-out 18.6447 APE10-dist-out 21.1274 APE9-dist-out 13.9765 None None None XRAY 3.34 0.265 0.283 C 384.0 308.0 34 26 26 0 [[68, 361]] 1.0 7jux Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JUYC P29678 40 382 393.0 ANP:401,EUI:402 ATPlike,Type3 Inactive DFGin 5.8023 13.9446 BLBplus -119.74, 162.94 62.38, 34.15 -75.02, 153.8 53.17, 104.23 -74.72, 81.57 out-out out 15.6895 Saltbr-out 15.7759 HRD-in -78.99, -50.85 75.95, -2.2 out-out-out SNCooo out-out ActLoopNT-out 8.6396 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -134.38, 125.81 APE9-dihe-na -89.68, -160.4 APE8-dihe-out -91.9, -17.82 APE8-rot-out 194.83 APE67-dihe-out -134.16, 130.72 -117.22, 165.02 APE12-dist-out 17.5274 APE11-dist-out 16.8292 APE10-dist-out 20.535 APE9-dist-out 12.5725 None None None XRAY 3.096 0.248 0.257 C 384.0 311.0 32 26 26 0 [[68, 361]] 1.0 7juy Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JUZC P29678 40 382 393.0 ANP:401,3EW:402 ATPlike,Type3 Inactive DFGin 5.9412 14.2448 BLBplus -127.35, 173.99 64.59, 36.11 -89.55, 153.11 55.39, 95.23 -79.11, 95.72 out-out out 16.8967 Saltbr-out 15.3901 HRD-in -78.66, -56.19 75.89, -1.31 out-out-out SNCooo out-out ActLoopNT-out 8.8285 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.68, 119.69 APE9-dihe-na -83.26, -173.5 APE8-dihe-out -76.47, -20.99 APE8-rot-out 195.18 APE67-dihe-out -133.01, 129.38 -114.64, 162.26 APE12-dist-out 17.257 APE11-dist-out 16.6053 APE10-dist-out 20.4548 APE9-dist-out 12.4227 None None None XRAY 3.21 0.255 0.272 C 384.0 308.0 35 26 26 0 [[68, 361]] 1.0 7juz Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JV0C P29678 40 382 393.0 ANP:401,4BM:402 ATPlike,Type3 Inactive DFGin 5.8727 14.2702 BLBplus -118.46, 167.04 65.91, 31.94 -77.55, 158.19 54.28, 101.68 -82.73, 82.06 out-out out 16.4454 Saltbr-out 16.8702 HRD-in -78.95, -48.37 72.45, 0.0 out-out-out SNCooo out-out ActLoopNT-out 8.9767 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -134.69, 127.82 APE9-dihe-na -92.23, -161.01 APE8-dihe-out -91.79, -17.2 APE8-rot-out 194.87 APE67-dihe-out -131.33, 129.9 -118.91, 161.4 APE12-dist-out 17.5672 APE11-dist-out 16.9191 APE10-dist-out 20.7981 APE9-dist-out 12.6788 None None None XRAY 3.63 0.247 0.26 C 384.0 308.0 35 26 26 0 [[68, 361]] 1.0 7jv0 Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JV1C P29678 40 381 393.0 ANP:401,VKG:402 ATPlike,Type3 Inactive DFGin 6.4027 13.987 BLBplus -129.45, -171.63 44.64, 33.58 -84.88, 163.88 41.4, 98.6 -82.69, 72.31 out-out out 17.7833 Saltbr-out 17.8868 HRD-in -72.64, -55.74 83.07, -10.49 out-out-out SNCooo out-out ActLoopNT-out 9.5186 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.03, 153.74 APE9-dihe-na -129.76, -140.43 APE8-dihe-out -102.55, -29.44 APE8-rot-out 180.23 APE67-dihe-out -122.99, 132.28 -101.94, 135.93 APE12-dist-out 15.759 APE11-dist-out 19.0444 APE10-dist-out 21.0399 APE9-dist-out 14.1526 None None None XRAY 3.62 0.278 0.303 C 384.0 308.0 34 26 26 0 [[68, 361]] 1.0 7jv1 Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 5KKRC P29678 41 381 393.0 No_ligand No_ligand Inactive DFGin 5.6864 14.7208 BLBplus -158.86, 161.03 54.66, 76.63 -127.36, 155.38 51.94, 88.12 -65.72, 114.93 out-out out 16.7672 Saltbr-out 17.5976 HRD-in -80.0, -34.43 65.62, -12.22 out-out-out SNCooo out-out ActLoopNT-out 9.8888 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -95.67, -78.94 APE9-dihe-na 120.42, 151.43 APE8-dihe-out -85.94, -11.72 APE8-rot-out 171.08 APE67-dihe-out -107.86, 142.56 -124.16, 111.31 APE12-dist-out 16.0673 APE11-dist-out 19.7439 APE10-dist-out 21.3477 APE9-dist-out 14.2327 None None None XRAY 3.509 0.252 0.287 C 395.0 309.0 32 26 26 0 [[68, 361]] 1.0 5kkr Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.5e-97 331.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
MAP2K1 MP2K1_RABIT 7JUSC P29678 41 381 393.0 VKD:501,ANP:502 Type3,ATPlike Inactive DFGin 6.6408 14.136 BLBplus -157.57, 158.09 64.1, 38.39 -94.54, 165.57 43.42, 100.58 -82.33, 83.96 out-out out 16.4432 Saltbr-out 17.0647 HRD-in -64.72, -50.01 79.43, -5.86 out-out-out SNCooo out-out ActLoopNT-out 9.2055 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -121.8, 123.06 APE9-dihe-na -111.39, -149.55 APE8-dihe-out -101.45, -2.19 APE8-rot-out 46.64 APE67-dihe-out -107.18, 138.05 -110.5, 111.25 APE12-dist-out 16.9565 APE11-dist-out 19.7412 APE10-dist-out 21.5845 APE9-dist-out 15.1016 None None None XRAY 2.99 0.249 0.265 C 384.0 304.0 37 26 26 0 [[68, 361]] 1.0 7jus Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1