TYR_EGFR (Epidermal growth factor receptor)

Total number of chains: 517
Active chains: 99
Family: TYR
Uniprot: EGFR_HUMAN
Kinase Domain Residues: 712 - 970
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 200 38.7% AF-P00533-K1A
DFGin BLBplus 166 32.1% 6V66D
DFGin BLBtrans 92 17.8% 6V66A
DFGin None 13 2.5% 4RIYD
DFGout BBAminus 12 2.3% 5HG8A
DFGin BLAplus 11 2.1% 8A2AA
DFGinter None 8 1.5% 2JIUB
DFGin ABAminus 6 1.2% 9XU9A
DFGout None 5 1.0% 4I1ZA
DFGin BLBminus 4 0.8% 8A2DA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
2ITXA 697 1019 1210.0 ANP:2020 ATPlike Active DFGin 5.874 15.737 BLAminus -136.31, -171.94 65.34, 93.22 -111.54, 18.75 298.27, 92.75 -59.44, 2.06 in-in in 9.241 Saltbr-in 3.583 HRD-in -62.41, -44.72 61.37, 7.79 in-in-in SNCiii in-in ActLoopNT-in 2.642 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.73, 124.39 APE9-dihe-in -125.4, 144.12 APE8-dihe-in -79.64, 94.32 APE8-rot-na 30.37 APE67-dihe-in -65.37, -0.17 -61.69, -47.61 APE12-dist-na 11.888 APE11-dist-na 10.151 APE10-dist-na 11.134 APE9-dist-in 7.058 None None None XRAY 2.98 0.191 0.261 A 327 307 4 0 0 4 [[712, 970]] 1.0 2itx TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8HV4A 696 1020 1210.0 PE5:1101,MWU:1102 Allosteric,Type1 Active DFGin 6.099 15.187 BLAminus -130.11, -171.57 60.63, 76.52 -95.44, 10.11 292.65, 96.39 -43.03, -44.61 in-in in 8.302 Saltbr-in 3.322 HRD-in -71.74, -51.9 75.14, 7.17 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.84, 107.0 APE9-dihe-in -115.33, 154.25 APE8-dihe-in -89.19, 79.02 APE8-rot-na 38.66 APE67-dihe-in -72.78, -5.6 -58.65, -42.93 APE12-dist-na 11.758 APE11-dist-na 10.396 APE10-dist-na 11.61 APE9-dist-in 7.39 E865A,E866A,K867A None None XRAY 2.2 0.239 0.275 A 331 304 6 0 0 3 [[712, 970]] 1.0 8hv4 TYR_EGFR_HUMAN TYR 3.5e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8HV6A 696 1020 1210.0 PE5:1101,N86:1102 Allosteric,Type1 Active DFGin 5.904 15.402 BLAminus -126.97, -177.08 64.65, 81.87 -97.77, 4.79 296.74, 96.36 -40.91, -42.24 in-in in 8.752 Saltbr-in 2.997 HRD-in -69.51, -52.61 72.53, 9.89 in-in-in SNCiii in-in ActLoopNT-in 2.775 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.57, 119.04 APE9-dihe-in -126.13, 154.51 APE8-dihe-in -87.49, 71.86 APE8-rot-na 40.33 APE67-dihe-in -73.01, -0.15 -52.84, -41.89 APE12-dist-na 11.924 APE11-dist-na 10.417 APE10-dist-na 11.442 APE9-dist-in 7.354 E865A,E866A,K867A None None XRAY 2.2 0.249 0.296 A 331 307 3 0 0 0 [[712, 970]] 1.0 8hv6 TYR_EGFR_HUMAN TYR 3.5e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8HV7A 696 1019 1210.0 PE5:1101,N8O:1102 Allosteric,Type1 Active DFGin 5.965 14.783 BLAminus -130.55, -167.28 53.08, 83.5 -92.28, 13.92 300.31, 94.88 -38.75, -43.45 in-in in 8.203 Saltbr-in 3.059 HRD-in -71.82, -54.11 72.62, 8.95 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.41, 111.31 APE9-dihe-in -116.24, 154.93 APE8-dihe-in -87.4, 80.61 APE8-rot-na 37.2 APE67-dihe-in -74.07, -9.58 -59.54, -41.0 APE12-dist-na 11.66 APE11-dist-na 10.259 APE10-dist-na 11.546 APE9-dist-in 7.176 E865A,E866A,K867A None None XRAY 2.69 0.222 0.29 A 331 301 10 0 0 6 [[712, 970]] 1.0 8hv7 TYR_EGFR_HUMAN TYR 3.5e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8HV8A 696 1019 1210.0 PE5:1101,N99:1102 Allosteric,Type1 Active DFGin 6.043 15.057 BLAminus -125.96, -170.32 55.74, 82.34 -96.51, 11.07 293.49, 92.75 -34.95, -51.58 in-in in 8.143 Saltbr-in 3.326 HRD-in -73.99, -49.75 71.98, 9.02 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.61, 118.18 APE9-dihe-in -124.65, 150.54 APE8-dihe-in -89.53, 80.34 APE8-rot-na 39.28 APE67-dihe-in -69.5, -3.25 -56.62, -45.74 APE12-dist-na 11.675 APE11-dist-na 10.369 APE10-dist-na 11.219 APE9-dist-in 7.28 C797S,E865A,E866A,K867A None None XRAY 2.4 0.234 0.283 A 331 305 4 0 0 0 [[712, 970]] 1.0 8hv8 TYR_EGFR_HUMAN TYR 3.5e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8HV9A 696 1019 1210.0 PE5:1101,N9L:1102 Allosteric,Type1 Active DFGin 5.916 15.132 BLAminus -143.82, -178.2 62.01, 78.91 -94.0, 24.14 301.61, 89.09 -64.67, -16.43 in-in in 8.101 Saltbr-in 2.657 HRD-in -69.38, -54.88 68.74, 2.52 in-in-in SNCiii in-in ActLoopNT-in 2.77 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.98, 135.96 APE9-dihe-in -139.68, 157.73 APE8-dihe-in -88.14, 76.12 APE8-rot-na 37.34 APE67-dihe-in -77.83, -6.94 -60.36, -47.24 APE12-dist-na 12.179 APE11-dist-na 10.885 APE10-dist-na 11.275 APE9-dist-in 7.023 E865A,E866A,K867A None None XRAY 2.5 0.254 0.274 A 331 306 4 0 0 0 [[712, 970]] 1.0 8hv9 TYR_EGFR_HUMAN TYR 3.5e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9BY6A 698 1009 1210.0 PDO:1301,Q6K:1302 Allosteric,Type1 Active DFGin 6.002 15.663 BLAminus -149.77, -168.8 56.86, 79.46 -96.38, 24.13 296.36, 92.05 -63.66, -24.81 in-in in 9.063 Saltbr-in 3.491 HRD-in -75.7, -50.64 70.26, 5.13 in-in-in SNCiii in-in ActLoopNT-in 2.955 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.71, 133.19 APE9-dihe-in -133.13, 146.74 APE8-dihe-in -72.35, 102.77 APE8-rot-na 25.41 APE67-dihe-in -79.34, -8.97 -76.98, -28.96 APE12-dist-na 12.695 APE11-dist-na 9.472 APE10-dist-na 11.091 APE9-dist-in 6.657 None None None XRAY 2.551 0.208 0.245 A 338 311 1 0 0 0 [[712, 970]] 1.0 9by6 TYR_EGFR_HUMAN TYR 1.2e-87 299.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8HV1A 696 1019 1210.0 PE5:1101,N6N:1102 Allosteric,Type1 Active DFGin 5.813 15.137 BLAminus -141.64, -174.89 64.07, 81.43 -91.77, 15.88 294.7, 99.28 -49.71, -35.13 in-in in 8.633 Saltbr-in 3.064 HRD-in -77.13, -49.05 68.6, 6.98 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.53, 105.98 APE9-dihe-in -114.36, 147.65 APE8-dihe-in -82.64, 80.16 APE8-rot-na 37.74 APE67-dihe-in -74.01, -6.57 -60.27, -40.96 APE12-dist-na 11.899 APE11-dist-na 10.789 APE10-dist-na 11.152 APE9-dist-in 7.211 E865A,E866A,K867A None None XRAY 2.4 0.191 0.219 A 331 309 4 0 0 0 [[712, 970]] 1.0 8hv1 TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8HV3A 696 1020 1210.0 PE5:1101,MWU:1103 Allosteric,Type1 Active DFGin 6.179 15.626 BLAminus -127.58, -179.0 62.59, 85.31 -101.31, 9.93 297.08, 83.02 -46.24, -27.8 in-in in 8.645 Saltbr-in 3.166 HRD-in -72.86, -48.63 69.9, 8.23 in-in-in SNCiii in-in ActLoopNT-in 2.918 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.05, 111.65 APE9-dihe-in -122.27, 146.52 APE8-dihe-in -88.12, 79.7 APE8-rot-na 39.71 APE67-dihe-in -75.54, -1.37 -55.44, -43.37 APE12-dist-na 12.055 APE11-dist-na 10.393 APE10-dist-na 11.129 APE9-dist-in 7.354 E865A,E866A,K867A None None XRAY 2.4 0.214 0.25 A 331 307 3 0 0 0 [[712, 970]] 1.0 8hv3 TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8HV5A 696 1019 1210.0 PE5:1101,N7C:1102 Allosteric,Type1 Active DFGin 5.973 15.251 BLAminus -130.95, 178.54 67.19, 85.27 -98.38, 23.1 296.48, 89.98 -54.53, -35.87 in-in in 8.727 Saltbr-in 3.383 HRD-in -76.07, -52.83 75.02, 1.85 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.39, 115.59 APE9-dihe-in -118.26, 144.05 APE8-dihe-in -81.44, 79.55 APE8-rot-na 38.48 APE67-dihe-in -70.6, -7.98 -54.36, -43.35 APE12-dist-na 11.884 APE11-dist-na 10.562 APE10-dist-na 10.953 APE9-dist-in 7.218 E865A,E866A,K867A None None XRAY 2.2 0.188 0.224 A 331 306 4 0 0 0 [[712, 970]] 1.0 8hv5 TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9BY4A 696 1010 1210.0 PDO:61301,Q6K:61302,PDO:61304,PDO:61305 Allosteric,Type1,Allosteric,Type1 Active DFGin 6.118 15.558 BLAminus -131.58, -170.69 55.04, 91.41 -104.93, 32.17 291.61, 87.59 -69.69, -25.35 in-in in 8.748 Saltbr-in 2.724 HRD-in -74.22, -51.47 72.05, 2.77 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.0, 133.58 APE9-dihe-in -140.48, 146.73 APE8-dihe-in -77.28, 98.44 APE8-rot-na 2.83 APE67-dihe-in -69.73, -13.67 -59.81, -44.15 APE12-dist-na 11.983 APE11-dist-na 10.159 APE10-dist-na 10.796 APE9-dist-in 6.63 None None None XRAY 2.307 0.197 0.22 A 338 315 0 0 0 0 [[712, 970]] 1.0 9by4 TYR_EGFR_HUMAN TYR 1.2e-87 299.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2JITA 696 1016 1210.0 No_ligand No_ligand Active DFGin 5.141 14.041 BLAminus -143.75, -163.53 58.3, 96.79 -111.32, 23.77 293.79, 72.87 -42.77, -57.72 in-in in 8.261 Saltbr-in 2.502 HRD-in -58.72, -42.55 61.63, -2.2 in-in-in SNCiii in-in ActLoopNT-in 2.786 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -40.92, 138.22 APE9-dihe-in -145.55, 148.59 APE8-dihe-in -78.1, 90.66 APE8-rot-na 34.4 APE67-dihe-in -72.3, 17.7 -56.07, -43.84 APE12-dist-na 11.533 APE11-dist-na 9.544 APE10-dist-na 10.076 APE9-dist-in 6.677 T790M None None XRAY 3.1 0.209 0.249 A 327 299 0 0 0 0 [[712, 970]] 1.0 2jit TYR_EGFR_HUMAN TYR 8e-88 300.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3UG1A 697 1018 1210.0 No_ligand No_ligand Active DFGin 6.051 15.036 BLAminus -138.29, -170.11 52.83, 84.83 -101.74, 16.86 292.59, 87.32 -38.57, -36.03 in-in in 8.591 Saltbr-in 3.196 HRD-in -75.17, -47.18 65.26, 2.66 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -59.69, 134.48 APE9-dihe-in -145.24, 146.09 APE8-dihe-in -85.72, 94.22 APE8-rot-na 29.06 APE67-dihe-in -67.27, -26.68 -59.74, -42.4 APE12-dist-na 12.324 APE11-dist-na 10.024 APE10-dist-na 10.841 APE9-dist-in 6.691 G719S,T790M None None XRAY 2.75 0.198 0.243 A 334 296 8 0 0 0 [[712, 970]] 1.0 3ug1 TYR_EGFR_HUMAN TYR 7.9e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
AF-P00533-K1A 704 978 1210.0 No_ligand No_ligand Active DFGin 6.266 14.441 BLAminus -142.4, -173.12 60.96, 66.69 -84.25, 12.66 292.71, 95.04 -61.7, -26.32 in-in in 8.942 Saltbr-in 2.794 HRD-in -75.23, -42.38 67.32, -16.15 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.94, 131.87 APE9-dihe-in -138.04, 147.31 APE8-dihe-in -82.82, 70.63 APE8-rot-na 37.07 APE67-dihe-in -69.79, -13.1 -41.77, -41.11 APE12-dist-na 11.218 APE11-dist-na 9.306 APE10-dist-na 9.628 APE9-dist-in 6.312 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[712, 970]] 1.0 AF-P00533-K1 TYR_EGFR_HUMAN TYR 5.6e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
AF-P00533-K3A 704 978 1210.0 No_ligand No_ligand Active DFGin 5.936 14.43 BLAminus -146.34, -169.18 58.09, 69.94 -83.67, 15.13 294.25, 94.7 -61.54, -24.2 in-in in 8.756 Saltbr-in 2.733 HRD-in -80.01, -43.56 66.74, -10.06 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.57, 132.53 APE9-dihe-in -139.42, 152.16 APE8-dihe-in -83.1, 63.7 APE8-rot-na 38.0 APE67-dihe-in -69.61, -12.53 -43.06, -39.9 APE12-dist-na 11.57 APE11-dist-na 9.564 APE10-dist-na 9.866 APE9-dist-in 6.216 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[712, 970]] 1.0 AF-P00533-K3 TYR_EGFR_HUMAN TYR 5.6e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2GS2A 696 1018 1210.0 No_ligand No_ligand Active DFGin 5.997 15.735 BLAminus -138.74, -166.72 52.64, 91.5 -108.19, 27.74 296.19, 95.26 -69.52, 15.47 in-in in 8.904 Saltbr-in 3.285 HRD-in -57.24, -44.44 63.22, -0.15 in-in-in SNCiii in-in ActLoopNT-in 2.757 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -43.38, 131.23 APE9-dihe-in -146.08, 139.35 APE8-dihe-in -71.11, 85.26 APE8-rot-na 34.08 APE67-dihe-in -66.56, -6.13 -61.32, -39.29 APE12-dist-na 12.249 APE11-dist-na 10.341 APE10-dist-na 10.593 APE9-dist-in 6.946 None None None XRAY 2.8 0.248 0.25 A 330 305 3 0 0 0 [[712, 970]] 1.0 2gs2 TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7SI1A 695 1020 1210.0 No_ligand No_ligand Active DFGin 6.064 15.686 BLAminus -133.46, -174.76 66.46, 79.13 -98.89, 26.24 291.41, 90.91 -66.32, -23.37 in-in in 9.539 Saltbr-in 3.575 HRD-in -73.1, -47.44 68.75, 2.06 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.26, 135.35 APE9-dihe-in -141.69, 143.81 APE8-dihe-in -69.91, 96.92 APE8-rot-na 342.32 APE67-dihe-in -71.17, -10.6 -59.76, -37.22 APE12-dist-na 12.27 APE11-dist-na 9.283 APE10-dist-na 10.182 APE9-dist-in 6.186 None None None XRAY 1.6 0.193 0.215 A 331 301 8 0 0 0 [[712, 970]] 1.0 7si1 TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4TKSA 697 1019 1210.0 No_ligand No_ligand Active DFGin 5.571 14.678 BLAminus -158.56, -164.67 57.08, 87.24 -106.21, 31.57 300.88, 109.29 -73.32, -8.78 in-in in 8.971 Saltbr-in 3.24 HRD-in -59.07, -49.82 64.12, 6.9 in-in-in SNCiii in-in ActLoopNT-in 2.839 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -139.97, 50.24 APE9-dihe-in -122.32, 130.38 APE8-dihe-in -59.17, 108.53 APE8-rot-na 18.98 APE67-dihe-in -72.46, -2.61 -63.0, -34.51 APE12-dist-na 10.288 APE11-dist-na 11.122 APE10-dist-na 8.744 APE9-dist-in 5.829 None None None XRAY 3.202 0.189 0.209 A 332 307 3 0 0 0 [[712, 970]] 1.0 4tks TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2EB2A 696 1019 1210.0 No_ligand No_ligand Active DFGin 5.986 15.614 BLAminus -133.54, -170.99 55.66, 80.97 -94.73, 26.04 295.94, 89.9 -62.59, -8.59 in-in in 8.81 Saltbr-in 3.07 HRD-in -68.4, -48.79 69.57, -2.64 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -37.18, 126.05 APE9-dihe-in -140.69, 139.08 APE8-dihe-in -73.53, 85.93 APE8-rot-na 37.45 APE67-dihe-in -69.5, -7.06 -58.22, -33.12 APE12-dist-na 11.929 APE11-dist-na 10.836 APE10-dist-na 10.769 APE9-dist-in 6.822 None None None XRAY 2.5 0.198 0.253 A 334 305 5 0 0 1 [[712, 970]] 1.0 2eb2 TYR_EGFR_HUMAN TYR 1e-86 296.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8H7XA 697 1019 1210.0 6GY:1500 Type1 Active DFGin 5.635 13.772 BLAminus -162.89, 168.84 77.21, 81.71 -97.92, 23.57 309.06, 76.3 -58.42, -31.29 in-in in 8.899 Saltbr-in 3.163 HRD-in -78.19, -35.41 64.93, 5.25 in-in-in SNCiii in-in ActLoopNT-in 3.032 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.33, 109.95 APE9-dihe-in -128.71, 142.43 APE8-dihe-in -73.85, 112.86 APE8-rot-na 33.56 APE67-dihe-in -80.76, -11.68 -63.25, -24.22 APE12-dist-na 12.291 APE11-dist-na 9.112 APE10-dist-na 10.289 APE9-dist-in 6.269 T790M,C797S None None XRAY 3.404 0.189 0.256 A 330 299 0 0 0 0 [[712, 970]] 1.0 8h7x TYR_EGFR_HUMAN TYR 6.2e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6JRXA 696 1017 1210.0 9JO:1101 Type1 Active DFGin 6.44 15.636 BLAminus -145.58, -162.02 54.03, 56.96 -80.77, 53.05 305.17, 63.84 -64.12, -39.93 in-in in 8.427 Saltbr-in 2.596 HRD-in -77.93, -47.62 78.43, -4.56 in-in-in SNCiii in-in ActLoopNT-in 3.037 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.79, 132.45 APE9-dihe-in -156.57, 137.89 APE8-dihe-in -87.12, 89.44 APE8-rot-na 31.88 APE67-dihe-in -67.25, -10.19 -63.92, -36.38 APE12-dist-na 12.449 APE11-dist-na 10.408 APE10-dist-na 10.442 APE9-dist-in 6.999 T790M,C797S None None XRAY 2.201 0.211 0.239 A 331 300 3 0 0 3 [[712, 970]] 1.0 6jrx TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5J9YA 697 1019 1210.0 6HL:1101 Type1 Active DFGin 6.024 15.621 BLAminus -143.43, -160.74 49.91, 84.26 -101.22, 18.94 291.9, 123.66 -49.61, -50.61 in-in in 8.437 Saltbr-in 3.447 HRD-in -67.06, -45.86 64.69, -10.5 in-in-in SNCiii in-in ActLoopNT-in 3.061 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.4, 148.12 APE9-dihe-in -143.13, 151.2 APE8-dihe-in -85.49, 83.09 APE8-rot-na 35.02 APE67-dihe-in -71.5, -10.87 -57.34, -38.25 APE12-dist-na 11.356 APE11-dist-na 10.476 APE10-dist-na 10.43 APE9-dist-in 6.959 None None None XRAY 2.8 0.185 0.237 A 323 300 3 0 0 3 [[712, 970]] 1.0 5j9y TYR_EGFR_HUMAN TYR 7.7e-88 300.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5X2KA 696 1020 1210.0 0UN:1101 Type1 Active DFGin 6.252 15.402 BLAminus -162.18, -166.94 57.57, 64.19 -89.05, 1.52 298.25, 111.15 -60.1, -40.29 in-in in 8.377 Saltbr-in 3.231 HRD-in -63.42, -47.14 78.88, -6.86 in-in-in SNCiii in-in ActLoopNT-in 2.731 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.48, 127.33 APE9-dihe-in -122.09, 137.71 APE8-dihe-in -92.31, 106.07 APE8-rot-na 35.16 APE67-dihe-in -60.76, -39.83 -65.9, -37.9 APE12-dist-na 13.719 APE11-dist-na 11.84 APE10-dist-na 11.783 APE9-dist-in 7.957 T790M None None XRAY 3.201 0.227 0.244 A 327 314 8 0 0 6 [[712, 970]] 1.0 5x2k TYR_EGFR_HUMAN TYR 8e-88 300.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4G5PA 696 1016 1210.0 0WN:1101 Type1 Active DFGin 5.344 13.739 BLAminus -124.18, 171.49 77.97, 83.84 -103.09, 36.7 302.05, 70.97 -80.0, -21.33 in-in in 9.077 Saltbr-in 2.945 HRD-in -92.74, -52.87 64.77, 7.63 in-in-in SNCiii in-in ActLoopNT-in 3.173 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.69, 138.82 APE9-dihe-in -143.62, 154.27 APE8-dihe-in -82.6, 99.87 APE8-rot-na 28.42 APE67-dihe-in -75.71, 45.37 -72.06, -48.88 APE12-dist-na 12.129 APE11-dist-na 9.824 APE10-dist-na 10.113 APE9-dist-in 6.844 T790M None None XRAY 3.17 0.247 0.323 A 330 299 0 0 0 0 [[712, 970]] 1.0 4g5p TYR_EGFR_HUMAN TYR 8.3e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5XDKA 696 1018 1210.0 8JC:1101 Type1 Active DFGin 6.291 15.643 BLAminus -142.28, -172.2 59.56, 71.93 -92.37, 20.08 293.91, 91.35 -59.68, -36.21 in-in in 8.839 Saltbr-in 3.331 HRD-in -63.72, -48.3 76.47, -9.14 in-in-in SNCiii in-in ActLoopNT-in 2.945 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -60.97, 134.48 APE9-dihe-in -140.79, 153.09 APE8-dihe-in -91.71, 90.6 APE8-rot-na 28.11 APE67-dihe-in -61.23, -29.7 -63.54, -39.18 APE12-dist-na 12.179 APE11-dist-na 9.723 APE10-dist-na 10.137 APE9-dist-in 7.217 T790M None None XRAY 2.346 0.219 0.248 A 331 307 1 0 0 0 [[712, 970]] 1.0 5xdk TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5Y9TA 697 1020 1210.0 8RC:1101 Type1 Active DFGin 5.591 14.994 BLAminus -156.88, -164.94 47.09, 81.43 -95.95, 53.11 305.68, 71.53 -51.53, -46.6 in-in in 8.418 Saltbr-in 2.871 HRD-in -67.84, -48.53 70.09, 0.08 in-in-in SNCiii in-in ActLoopNT-in 2.76 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.86, 138.76 APE9-dihe-in -150.48, 158.92 APE8-dihe-in -71.48, 121.98 APE8-rot-na 32.48 APE67-dihe-in -69.03, -24.42 -97.45, -47.49 APE12-dist-na 12.153 APE11-dist-na 10.175 APE10-dist-na 11.054 APE9-dist-in 6.736 T790M None None XRAY 3.25 0.197 0.24 A 333 300 2 0 0 0 [[712, 970]] 1.0 5y9t TYR_EGFR_HUMAN TYR 8.5e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6S89A 697 1017 1210.0 L0Q:1101 Type1 Active DFGin 6.066 15.231 BLAminus -157.33, -148.66 33.58, 65.8 -75.53, 25.04 305.17, 80.95 -54.51, -45.13 in-in in 8.9 Saltbr-in 3.363 HRD-in -72.93, -41.71 66.27, -3.02 in-in-in SNCiii in-in ActLoopNT-in 3.078 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.23, 124.56 APE9-dihe-in -147.22, 151.7 APE8-dihe-in -85.44, 104.69 APE8-rot-na 30.93 APE67-dihe-in -61.24, -22.25 -66.61, -40.14 APE12-dist-na 12.584 APE11-dist-na 10.214 APE10-dist-na 10.438 APE9-dist-in 6.731 T790M,C797S,E865A,E866A,K867A None None XRAY 2.701 0.191 0.234 A 333 310 0 0 0 0 [[712, 970]] 1.0 6s89 TYR_EGFR_HUMAN TYR 3.4e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6S8AA 697 1018 1210.0 L0N:1102 Type1 Active DFGin 5.838 15.005 BLAminus -148.49, -160.53 51.03, 78.18 -97.72, 23.3 297.38, 81.01 -61.33, -21.09 in-in in 8.432 Saltbr-in 3.249 HRD-in -78.55, -44.18 72.7, -6.87 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.4, 134.04 APE9-dihe-in -159.56, 141.97 APE8-dihe-in -84.6, 100.84 APE8-rot-na 30.13 APE67-dihe-in -69.92, -1.38 -68.54, -39.36 APE12-dist-na 12.364 APE11-dist-na 10.156 APE10-dist-na 10.195 APE9-dist-in 6.636 T790M,C797S,E865A,E866A,K867A None None XRAY 2.6 0.187 0.207 A 333 313 0 0 0 0 [[712, 970]] 1.0 6s8a TYR_EGFR_HUMAN TYR 3.4e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7ZYMA 696 1020 1210.0 6GY:1101 Type1 Active DFGin 6.105 14.6 BLAminus -125.58, -171.05 53.24, 83.12 -97.68, 28.42 294.56, 85.3 -63.28, -32.0 in-in in 8.44 Saltbr-in 2.735 HRD-in -69.53, -46.77 68.71, 4.77 in-in-in SNCiii in-in ActLoopNT-in 3.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.21, 113.9 APE9-dihe-in -126.31, 139.74 APE8-dihe-in -66.94, 111.98 APE8-rot-na 339.42 APE67-dihe-in -73.89, -7.64 -66.97, -37.27 APE12-dist-na 12.195 APE11-dist-na 9.561 APE10-dist-na 10.212 APE9-dist-in 6.152 T790M,C797S,E865A,E866A,K867A None None XRAY 2.5 0.194 0.224 A 333 321 4 0 0 0 [[712, 970]] 1.0 7zym TYR_EGFR_HUMAN TYR 3.4e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7ZYNA 697 1018 1210.0 0UN:1101 Type1 Active DFGin 5.896 15.046 BLAminus -145.65, -166.89 58.05, 78.44 -95.11, 31.85 294.9, 83.85 -65.75, -30.64 in-in in 8.443 Saltbr-in 2.894 HRD-in -73.97, -47.38 70.32, 2.73 in-in-in SNCiii in-in ActLoopNT-in 2.899 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.42, 134.47 APE9-dihe-in -142.75, 146.34 APE8-dihe-in -74.74, 108.36 APE8-rot-na 25.93 APE67-dihe-in -69.45, -12.52 -69.08, -37.0 APE12-dist-na 12.422 APE11-dist-na 9.178 APE10-dist-na 10.479 APE9-dist-in 6.554 T790M,C797S,E865A,E866A,K867A None None XRAY 2.3 0.193 0.223 A 333 317 4 0 0 0 [[712, 970]] 1.0 7zyn TYR_EGFR_HUMAN TYR 3.4e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9JQ1A 697 1020 1210.0 A1ECU:1101 Type1 Active DFGin 6.005 15.078 BLAminus -137.71, -176.02 59.58, 86.62 -103.58, 31.57 295.05, 88.33 -63.15, -37.97 in-in in 9.031 Saltbr-in 3.048 HRD-in -72.34, -47.27 62.84, 14.69 in-in-in SNCiii in-in ActLoopNT-in 2.745 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.22, 122.29 APE9-dihe-in -118.99, 149.75 APE8-dihe-in -78.94, 88.43 APE8-rot-na 27.81 APE67-dihe-in -74.08, -19.43 -66.07, -32.51 APE12-dist-na 12.153 APE11-dist-na 10.844 APE10-dist-na 11.514 APE9-dist-in 7.168 T790M,C797S,L858R None None XRAY 3.02 0.208 0.274 A 329 301 0 0 0 0 [[712, 970]] 1.0 9jq1 TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7OXBA 696 1019 1210.0 35Z:61101 Type1 Active DFGin 6.005 14.131 BLAminus -130.75, 177.91 66.07, 88.81 -104.72, 27.62 297.72, 96.38 -64.38, -30.99 in-in in 8.408 Saltbr-in 2.726 HRD-in -68.89, -46.33 64.93, 14.34 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.05, 121.7 APE9-dihe-in -135.03, 157.35 APE8-dihe-in -86.06, 80.53 APE8-rot-na 33.4 APE67-dihe-in -72.72, -10.35 -56.13, -39.45 APE12-dist-na 12.247 APE11-dist-na 10.768 APE10-dist-na 10.966 APE9-dist-in 7.086 None None None XRAY 2.56 0.2 0.227 A 326 304 9 0 0 6 [[712, 970]] 1.0 7oxb TYR_EGFR_HUMAN TYR 8.3e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8WD4A 696 1019 1210.0 W7W:61101 Type1 Active DFGin 5.75 14.795 BLAminus -142.64, -169.33 67.07, 74.8 -90.88, 19.87 297.57, 96.01 -60.59, -23.31 in-in in 8.537 Saltbr-in 3.088 HRD-in -63.82, -45.12 67.16, 11.96 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.75, 139.9 APE9-dihe-in -137.85, 143.39 APE8-dihe-in -80.86, 75.13 APE8-rot-na 35.93 APE67-dihe-in -75.8, -15.34 -53.39, -39.55 APE12-dist-na 999.0 APE11-dist-na 11.806 APE10-dist-na 11.642 APE9-dist-in 7.283 T790M,C797S,L858R None None XRAY 2.55 0.201 0.23 A 329 297 14 0 0 11 [[712, 970]] 1.0 8wd4 TYR_EGFR_HUMAN TYR 3.4e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6LUBA 696 1018 1210.0 EUX:1101 Type1 Active DFGin 5.507 14.662 BLAminus -139.91, -166.33 58.26, 84.4 -97.54, 21.21 297.41, 97.99 -62.0, -20.37 in-in in 8.855 Saltbr-in 3.016 HRD-in -74.79, -46.54 66.43, 4.09 in-in-in SNCiii in-in ActLoopNT-in 2.876 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.27, 110.9 APE9-dihe-in -113.24, 152.31 APE8-dihe-in -82.46, 86.31 APE8-rot-na 29.56 APE67-dihe-in -71.55, -1.57 -60.93, -45.76 APE12-dist-na 12.33 APE11-dist-na 11.064 APE10-dist-na 11.386 APE9-dist-in 7.295 T790M,C797S,L858R,E865A,E866A,K867A None None XRAY 2.315 0.187 0.226 A 329 301 7 0 0 0 [[712, 970]] 1.0 6lub TYR_EGFR_HUMAN TYR 3.4e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6LUDA 696 1018 1210.0 YY3:1101 Type1 Active DFGin 5.801 15.169 BLAminus -139.67, -168.77 58.93, 81.91 -96.56, 23.75 296.99, 89.34 -60.73, -21.77 in-in in 8.713 Saltbr-in 3.093 HRD-in -76.11, -49.39 70.4, 3.5 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.38, 124.7 APE9-dihe-in -132.42, 154.45 APE8-dihe-in -81.46, 86.05 APE8-rot-na 32.74 APE67-dihe-in -70.42, -2.77 -62.03, -42.63 APE12-dist-na 12.592 APE11-dist-na 11.47 APE10-dist-na 11.485 APE9-dist-in 7.154 T790M,C797S,L858R,E865A,E866A,K867A None None XRAY 2.05 0.207 0.222 A 329 310 4 0 0 0 [[712, 970]] 1.0 6lud TYR_EGFR_HUMAN TYR 3.4e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9D3WA 696 1017 1210.0 A1A5L:61101 Type1 Active DFGin 6.181 15.57 BLAminus -136.54, -172.1 77.31, 72.47 -94.15, 28.51 288.41, 98.97 -88.92, 1.56 in-in in 8.774 Saltbr-in 2.829 HRD-in -71.84, -47.28 76.58, -3.9 in-in-in SNCiii in-in ActLoopNT-in 2.783 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.71, 124.38 APE9-dihe-in -135.31, 152.49 APE8-dihe-in -84.29, 71.1 APE8-rot-na 32.71 APE67-dihe-in -77.0, -3.61 -47.12, -41.12 APE12-dist-na 999.0 APE11-dist-na 11.089 APE10-dist-na 11.435 APE9-dist-in 7.186 C797S,E865A,E866A,K867A None None XRAY 2.53 0.271 0.31 A 330 299 11 0 0 11 [[712, 970]] 1.0 9d3w TYR_EGFR_HUMAN TYR 3.5e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8HVAA 696 1020 1210.0 N9R:1101 Type1 Active DFGin 5.629 14.626 BLAminus -142.87, -171.87 53.74, 75.85 -88.72, 14.21 297.7, 87.76 -41.85, -26.92 in-in in 8.391 Saltbr-in 2.892 HRD-in -78.5, -43.43 65.26, 13.72 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.37, 104.59 APE9-dihe-in -119.11, 152.21 APE8-dihe-in -89.9, 80.48 APE8-rot-na 36.24 APE67-dihe-in -71.75, -14.49 -57.22, -41.26 APE12-dist-na 12.118 APE11-dist-na 10.703 APE10-dist-na 10.819 APE9-dist-in 7.159 E865A,E866A,K867A None None XRAY 2.77 0.243 0.251 A 331 301 8 0 0 4 [[712, 970]] 1.0 8hva TYR_EGFR_HUMAN TYR 3.5e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6JZ0A 696 1019 1210.0 CKO:1100 Type1 Active DFGin 5.809 15.229 BLAminus -149.65, -162.74 55.21, 78.34 -98.1, 0.99 288.09, 110.24 -45.59, 147.35 in-in in 8.593 Saltbr-in 2.704 HRD-in -72.36, -40.29 62.49, 10.68 in-in-in SNCiii in-in ActLoopNT-in 2.969 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -132.61, 70.32 APE9-dihe-in -120.17, 145.56 APE8-dihe-in -61.09, 122.05 APE8-rot-na 335.79 APE67-dihe-in -79.37, -10.06 -69.5, -36.0 APE12-dist-na 10.463 APE11-dist-na 10.753 APE10-dist-na 10.077 APE9-dist-in 5.803 None None None XRAY 2.86 0.193 0.248 A 326 311 1 0 0 0 [[712, 970]] 1.0 6jz0 TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2J6MA 697 1020 1210.0 AEE:2021 Type1 Active DFGin 5.591 14.628 BLAminus -132.01, -171.36 64.21, 86.56 -104.74, 23.26 301.97, 101.16 -61.7, -5.65 in-in in 8.642 Saltbr-in 3.021 HRD-in -66.75, -41.48 62.82, -7.14 in-in-in SNCiii in-in ActLoopNT-in 2.789 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.86, 117.91 APE9-dihe-in -126.99, 135.18 APE8-dihe-in -74.97, 82.99 APE8-rot-na 39.67 APE67-dihe-in -53.8, -21.73 -47.34, -52.41 APE12-dist-na 11.859 APE11-dist-na 10.864 APE10-dist-na 10.63 APE9-dist-in 6.911 None None None XRAY 3.1 0.202 0.249 A 327 306 0 0 0 0 [[712, 970]] 1.0 2j6m TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6VH4A 696 1019 1210.0 QQM:1101 Type1 Active DFGin 5.858 14.975 BLAminus -138.49, -176.66 62.27, 90.53 -108.38, 27.1 297.52, 94.9 -62.11, -28.1 in-in in 8.621 Saltbr-in 3.08 HRD-in -71.21, -46.14 69.11, 4.32 in-in-in SNCiii in-in ActLoopNT-in 2.802 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.28, 125.12 APE9-dihe-in -131.93, 146.48 APE8-dihe-in -80.03, 99.7 APE8-rot-na 27.92 APE67-dihe-in -73.83, -4.5 -65.24, -44.12 APE12-dist-na 9.865 APE11-dist-na 11.078 APE10-dist-na 10.515 APE9-dist-in 6.81 None None None XRAY 2.8 0.197 0.23 A 327 295 8 0 0 3 [[712, 970]] 1.0 6vh4 TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9MSSA 697 1017 1210.0 A1BYO:1101 Type1 Active DFGin 6.184 14.804 BLAminus -134.33, -176.16 59.86, 84.75 -104.85, 30.86 296.07, 84.32 -66.61, -23.09 in-in in 8.312 Saltbr-in 2.617 HRD-in -73.45, -46.13 67.35, 7.26 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.18, 138.87 APE9-dihe-in -151.48, 152.93 APE8-dihe-in -70.72, 93.17 APE8-rot-na 28.39 APE67-dihe-in -75.67, 1.81 -61.61, -40.33 APE12-dist-na 999.0 APE11-dist-na 10.522 APE10-dist-na 10.737 APE9-dist-in 6.592 None None None XRAY 2.09 0.222 0.237 A 327 286 13 0 0 6 [[712, 970]] 1.0 9mss TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9MSTA 696 1017 1210.0 A1BYN:61101 Type1 Active DFGin 6.037 15.39 BLAminus -134.45, -174.2 61.81, 83.8 -103.16, 31.07 297.52, 96.34 -66.69, -19.6 in-in in 8.744 Saltbr-in 2.949 HRD-in -74.65, -47.17 67.74, 8.39 in-in-in SNCiii in-in ActLoopNT-in 2.818 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.07, 133.39 APE9-dihe-in -149.49, 143.42 APE8-dihe-in -77.29, 100.59 APE8-rot-na 27.65 APE67-dihe-in -79.32, -0.33 -68.37, -36.21 APE12-dist-na 11.759 APE11-dist-na 10.429 APE10-dist-na 10.823 APE9-dist-in 6.619 None None None XRAY 2.57 0.232 0.258 A 327 287 14 0 0 5 [[712, 970]] 1.0 9mst TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9H42A 696 1019 1210.0 A1IR8:61101 Type1 Active DFGin 6.202 15.889 BLAminus -134.07, 179.9 63.14, 84.66 -102.35, 3.72 299.09, 134.62 -33.22, -65.75 in-in in 9.087 Saltbr-in 2.932 HRD-in -73.11, -52.34 78.62, -3.39 in-in-in SNCiii in-in ActLoopNT-in 3.115 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.16, 146.69 APE9-dihe-in -133.99, 146.2 APE8-dihe-in -101.03, 75.13 APE8-rot-na 36.59 APE67-dihe-in -68.67, -11.17 -72.94, -29.53 APE12-dist-na 12.4 APE11-dist-na 10.77 APE10-dist-na 10.767 APE9-dist-in 7.832 None None None XRAY 2.601 0.187 0.245 A 328 324 0 0 0 0 [[712, 970]] 1.0 9h42 TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9H47A 696 1019 1210.0 A1IR9:61101 Type1 Active DFGin 6.569 15.831 BLAminus -132.58, -176.52 63.27, 77.94 -102.29, 18.33 296.7, 137.07 -57.08, -63.89 in-in in 8.918 Saltbr-in 2.882 HRD-in -71.97, -52.02 79.14, -6.34 in-in-in SNCiii in-in ActLoopNT-in 3.084 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.16, 151.68 APE9-dihe-in -136.6, 151.52 APE8-dihe-in -101.1, 75.9 APE8-rot-na 36.31 APE67-dihe-in -66.97, -10.87 -73.39, -30.03 APE12-dist-na 12.438 APE11-dist-na 10.958 APE10-dist-na 11.226 APE9-dist-in 7.746 None None None XRAY 2.991 0.202 0.244 A 328 324 0 0 0 0 [[712, 970]] 1.0 9h47 TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5FEDA 697 1017 1210.0 5X4:1101 Type1 Active DFGin 6.189 14.687 BLAminus -132.06, 176.3 73.46, 78.92 -101.41, 14.2 298.37, 98.14 -61.64, -39.27 in-in in 8.591 Saltbr-in 2.951 HRD-in -71.77, -46.99 67.31, -1.0 in-in-in SNCiii in-in ActLoopNT-in 3.038 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.35, 141.07 APE9-dihe-in -143.22, 147.19 APE8-dihe-in -79.09, 97.45 APE8-rot-na 29.19 APE67-dihe-in -72.55, -20.06 -64.96, -33.09 APE12-dist-na 12.459 APE11-dist-na 9.877 APE10-dist-na 10.932 APE9-dist-in 6.768 None None None XRAY 2.651 0.186 0.217 A 328 288 12 0 0 4 [[712, 970]] 1.0 5fed TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7T4IA 697 1017 1210.0 R28:2500 Type1 Active DFGin 6.176 15.419 BLAminus -134.59, -174.82 67.2, 83.56 -99.26, 19.99 299.76, 93.96 -46.8, -37.05 in-in in 8.675 Saltbr-in 2.804 HRD-in -73.31, -54.28 79.02, 0.69 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.0, 142.26 APE9-dihe-in -143.46, 152.77 APE8-dihe-in -85.15, 103.65 APE8-rot-na 32.16 APE67-dihe-in -74.65, -13.42 -69.82, -40.13 APE12-dist-na 12.549 APE11-dist-na 9.892 APE10-dist-na 10.85 APE9-dist-in 7.003 None None None XRAY 2.61 0.184 0.238 A 328 309 0 0 0 0 [[712, 970]] 1.0 7t4i TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4LI5A 696 1020 1210.0 1WY:61101 Type1 Active DFGin 6.026 14.162 BLAminus -131.0, -176.73 65.77, 86.42 -104.38, 23.51 292.36, 92.5 -61.36, -28.57 in-in in 8.377 Saltbr-in 3.261 HRD-in -74.32, -49.54 74.09, -0.72 in-in-in SNCiii in-in ActLoopNT-in 2.918 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.05, 130.94 APE9-dihe-in -140.59, 141.96 APE8-dihe-in -66.3, 105.4 APE8-rot-na 342.58 APE67-dihe-in -77.77, -5.8 -61.35, -32.71 APE12-dist-na 12.142 APE11-dist-na 9.774 APE10-dist-na 10.382 APE9-dist-in 6.112 None None None XRAY 2.64 0.166 0.203 A 328 303 0 0 0 0 [[712, 970]] 1.0 4li5 TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4I23A 695 1018 1210.0 1C9:9001 Type1 Active DFGin 5.831 14.799 BLAminus -136.95, -174.22 62.68, 72.46 -94.9, 21.34 301.95, 95.75 -66.8, 22.74 in-in in 8.738 Saltbr-in 2.785 HRD-in -56.19, -44.26 64.75, 4.02 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.49, 132.64 APE9-dihe-in -135.81, 134.69 APE8-dihe-in -75.01, 107.02 APE8-rot-na 32.25 APE67-dihe-in -70.4, -28.14 -84.36, -22.76 APE12-dist-na 12.219 APE11-dist-na 10.388 APE10-dist-na 10.927 APE9-dist-in 6.774 None None None XRAY 2.8 0.229 0.279 A 329 304 5 0 0 0 [[712, 970]] 1.0 4i23 TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5UGBA 695 1018 1210.0 8BM:9001 Type1 Active DFGin 5.835 14.651 BLAminus -134.46, -178.88 69.24, 78.86 -98.25, 26.83 301.46, 96.9 -60.13, -9.04 in-in in 8.798 Saltbr-in 2.83 HRD-in -79.7, -47.46 72.87, -2.89 in-in-in SNCiii in-in ActLoopNT-in 2.867 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.56, 109.91 APE9-dihe-in -106.09, 146.18 APE8-dihe-in -73.44, 111.13 APE8-rot-na 29.02 APE67-dihe-in -77.49, -5.29 -73.0, -29.08 APE12-dist-na 12.245 APE11-dist-na 10.361 APE10-dist-na 11.122 APE9-dist-in 6.287 None None None XRAY 2.53 0.216 0.251 A 329 307 2 0 0 0 [[712, 970]] 1.0 5ugb TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7AEIA 697 1018 1210.0 R85:1101 Type1 Active DFGin 6.208 14.792 BLAminus -126.01, -169.45 55.16, 81.89 -96.08, 14.73 291.11, 108.26 -69.45, 12.21 in-in in 8.768 Saltbr-in 3.443 HRD-in -60.05, -48.12 65.53, 1.77 in-in-in SNCiii in-in ActLoopNT-in 2.818 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -60.35, 121.7 APE9-dihe-in -129.58, 132.22 APE8-dihe-in -78.63, 102.11 APE8-rot-na 17.26 APE67-dihe-in -70.55, -9.57 -65.82, -33.23 APE12-dist-na 11.817 APE11-dist-na 10.052 APE10-dist-na 10.814 APE9-dist-in 6.719 None None None XRAY 2.65 0.196 0.234 A 329 315 2 0 0 0 [[712, 970]] 1.0 7aei TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9FZRA 696 1019 1210.0 A1IHC:1101 Type1 Active DFGin 5.859 14.582 BLAminus -136.77, -162.41 64.21, 71.65 -93.43, 21.81 293.45, 102.18 -73.25, -5.87 in-in in 8.367 Saltbr-in 2.902 HRD-in -77.53, -49.65 72.64, -0.27 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.76, 132.8 APE9-dihe-in -127.36, 148.53 APE8-dihe-in -82.36, 72.78 APE8-rot-na 39.77 APE67-dihe-in -76.27, 2.11 -52.52, -42.1 APE12-dist-na 11.814 APE11-dist-na 10.176 APE10-dist-na 10.925 APE9-dist-in 7.052 None None None XRAY 1.991 0.189 0.233 A 329 324 0 0 0 0 [[712, 970]] 1.0 9fzr TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9FZSA 696 1019 1210.0 A1IHD:1101 Type1 Active DFGin 5.721 14.664 BLAminus -136.17, -166.26 65.85, 70.42 -92.09, 18.91 293.3, 103.28 -70.03, -3.34 in-in in 8.381 Saltbr-in 2.903 HRD-in -74.04, -50.49 73.77, -1.21 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.95, 138.36 APE9-dihe-in -133.01, 146.9 APE8-dihe-in -83.18, 78.47 APE8-rot-na 33.99 APE67-dihe-in -74.96, -5.94 -62.28, -35.01 APE12-dist-na 12.075 APE11-dist-na 10.146 APE10-dist-na 10.869 APE9-dist-in 7.081 None None None XRAY 2.121 0.196 0.237 A 329 324 0 0 0 0 [[712, 970]] 1.0 9fzs TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4WKQA 696 1020 1210.0 IRE:61101 Type1 Active DFGin 5.87 14.27 BLAminus -136.93, -167.98 56.09, 82.01 -98.49, 20.74 290.51, 104.81 -58.21, -26.99 in-in in 8.496 Saltbr-in 2.777 HRD-in -72.77, -46.24 69.32, 1.48 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.97, 133.87 APE9-dihe-in -143.86, 136.85 APE8-dihe-in -65.0, 99.96 APE8-rot-na 331.29 APE67-dihe-in -71.38, -8.88 -57.65, -38.22 APE12-dist-na 12.229 APE11-dist-na 9.741 APE10-dist-na 10.136 APE9-dist-in 6.148 None None CSX797 XRAY 1.85 0.196 0.225 A 330 295 8 0 0 0 [[712, 970]] 1.0 4wkq TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8SC7A 696 1019 1210.0 D0D:61103 Type1 Active DFGin 5.703 14.779 BLAminus -139.2, -168.32 65.12, 69.36 -88.74, 17.57 294.89, 100.25 -60.65, -23.49 in-in in 8.53 Saltbr-in 2.694 HRD-in -75.7, -43.54 68.68, -2.69 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.67, 135.95 APE9-dihe-in -137.41, 139.41 APE8-dihe-in -85.95, 80.26 APE8-rot-na 35.46 APE67-dihe-in -72.73, -8.0 -55.77, -34.53 APE12-dist-na 12.176 APE11-dist-na 9.922 APE10-dist-na 9.889 APE9-dist-in 6.936 None None None XRAY 1.984 0.187 0.216 A 330 324 0 0 0 0 [[712, 970]] 1.0 8sc7 TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9KL4A 696 1019 1210.0 A1L53:1101 Type1 Active DFGin 5.882 14.873 BLAminus -137.95, -173.96 67.15, 83.4 -96.91, 17.41 294.77, 100.38 -52.64, -41.23 in-in in 8.615 Saltbr-in 3.086 HRD-in -70.73, -50.16 70.67, 8.63 in-in-in SNCiii in-in ActLoopNT-in 2.867 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.29, 144.18 APE9-dihe-in -146.46, 153.32 APE8-dihe-in -90.55, 99.64 APE8-rot-na 31.82 APE67-dihe-in -68.73, -13.99 -62.45, -40.55 APE12-dist-na 11.663 APE11-dist-na 9.882 APE10-dist-na 10.641 APE9-dist-in 6.875 None None None XRAY 2.32 0.189 0.238 A 330 313 0 0 0 0 [[712, 970]] 1.0 9kl4 TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5CAVA 697 1020 1210.0 4ZQ:1101 Type1 Active DFGin 5.728 15.178 BLAminus -144.14, -171.01 62.22, 83.13 -95.58, 29.43 294.47, 99.62 -62.26, -29.69 in-in in 8.891 Saltbr-in 2.886 HRD-in -61.83, -49.9 69.79, -4.81 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.05, 121.92 APE9-dihe-in -127.65, 141.47 APE8-dihe-in -77.45, 96.85 APE8-rot-na 26.93 APE67-dihe-in -72.16, -12.12 -60.35, -39.9 APE12-dist-na 11.975 APE11-dist-na 10.062 APE10-dist-na 10.409 APE9-dist-in 6.468 None None None XRAY 2.73 0.198 0.231 A 331 306 0 0 0 0 [[712, 970]] 1.0 5cav TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5EM8A 696 1018 1210.0 5Q4:1101 Type1 Active DFGin 6.262 14.789 BLAminus -136.52, -174.1 61.67, 87.27 -100.82, 25.52 292.95, 95.53 -58.03, -32.6 in-in in 8.649 Saltbr-in 2.943 HRD-in -59.6, -53.0 72.37, -0.6 in-in-in SNCiii in-in ActLoopNT-in 2.806 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.98, 123.11 APE9-dihe-in -124.21, 147.07 APE8-dihe-in -85.24, 91.96 APE8-rot-na 26.09 APE67-dihe-in -68.99, -10.46 -52.36, -42.63 APE12-dist-na 11.849 APE11-dist-na 9.73 APE10-dist-na 10.702 APE9-dist-in 6.636 None None None XRAY 2.8 0.191 0.229 A 331 303 5 0 0 2 [[712, 970]] 1.0 5em8 TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7KXZA 696 1017 1210.0 XA4:1102 Type1 Active DFGin 5.92 14.588 BLAminus -136.31, -168.83 60.33, 83.14 -97.98, 27.21 293.22, 85.75 -65.75, -18.76 in-in in 8.543 Saltbr-in 2.474 HRD-in -75.7, -47.88 69.93, 6.54 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.33, 134.32 APE9-dihe-in -142.53, 141.1 APE8-dihe-in -75.24, 95.2 APE8-rot-na 20.58 APE67-dihe-in -77.94, 1.68 -59.99, -41.31 APE12-dist-na 12.252 APE11-dist-na 10.145 APE10-dist-na 10.533 APE9-dist-in 6.649 None None None XRAY 2.4 0.191 0.219 A 331 299 4 0 0 0 [[712, 970]] 1.0 7kxz TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7U99A 695 1018 1210.0 M0R:61101 Type1 Active DFGin 5.755 14.716 BLAminus -136.96, -164.91 59.51, 80.36 -97.33, 25.45 292.89, 108.43 -72.5, -16.29 in-in in 8.574 Saltbr-in 2.775 HRD-in -72.48, -53.99 74.78, 0.57 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.44, 137.22 APE9-dihe-in -138.33, 149.04 APE8-dihe-in -75.25, 92.8 APE8-rot-na 11.47 APE67-dihe-in -78.7, 1.11 -63.71, -39.94 APE12-dist-na 11.835 APE11-dist-na 10.072 APE10-dist-na 10.731 APE9-dist-in 6.481 None None None XRAY 2.5 0.189 0.214 A 331 303 0 0 0 0 [[712, 970]] 1.0 7u99 TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8F1HA 697 1018 1210.0 X9H:1101 Type1 Active DFGin 5.457 14.887 BLAminus -145.15, -171.29 62.16, 94.67 -110.53, 25.16 293.79, 96.97 -66.2, -17.77 in-in in 9.35 Saltbr-in 2.996 HRD-in -63.65, -43.09 65.18, 5.08 in-in-in SNCiii in-in ActLoopNT-in 2.979 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -53.29, 129.01 APE9-dihe-in -138.63, 144.06 APE8-dihe-in -72.09, 88.56 APE8-rot-na 27.99 APE67-dihe-in -71.49, 2.29 -62.91, -34.63 APE12-dist-na 12.2 APE11-dist-na 10.244 APE10-dist-na 10.519 APE9-dist-in 6.589 None None None XRAY 2.8 0.186 0.212 A 331 307 0 0 0 0 [[712, 970]] 1.0 8f1h TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8F1XA 696 1018 1210.0 R28:1101 Type1 Active DFGin 5.983 15.01 BLAminus -136.15, -173.95 61.32, 87.85 -107.98, 33.07 295.84, 87.53 -69.26, -26.04 in-in in 8.386 Saltbr-in 2.835 HRD-in -75.88, -47.81 70.31, 4.02 in-in-in SNCiii in-in ActLoopNT-in 2.807 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.75, 114.5 APE9-dihe-in -126.56, 132.44 APE8-dihe-in -61.97, 98.31 APE8-rot-na 23.91 APE67-dihe-in -74.89, 2.26 -62.79, -43.67 APE12-dist-na 12.267 APE11-dist-na 9.833 APE10-dist-na 10.674 APE9-dist-in 6.627 None None None XRAY 2.3 0.205 0.226 A 331 317 3 0 0 0 [[712, 970]] 1.0 8f1x TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8F1YA 696 1019 1210.0 R2E:1101 Type1 Active DFGin 5.893 15.215 BLAminus -140.27, -173.76 62.92, 82.37 -103.43, 34.41 296.38, 97.61 -65.28, -35.48 in-in in 8.767 Saltbr-in 3.103 HRD-in -72.9, -46.1 67.76, 1.27 in-in-in SNCiii in-in ActLoopNT-in 3.077 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -54.27, 107.83 APE9-dihe-in -116.34, 152.7 APE8-dihe-in -84.23, 88.9 APE8-rot-na 19.13 APE67-dihe-in -72.32, -8.46 -55.36, -45.52 APE12-dist-na 11.785 APE11-dist-na 9.572 APE10-dist-na 10.376 APE9-dist-in 6.803 None None None XRAY 2.75 0.206 0.228 A 331 293 9 0 0 3 [[712, 970]] 1.0 8f1y TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8TJLA 696 1019 1210.0 HZ6:1101 Type1 Active DFGin 5.797 15.097 BLAminus -141.02, -174.36 63.37, 90.63 -108.66, 26.85 295.65, 94.46 -59.59, -43.72 in-in in 8.964 Saltbr-in 2.83 HRD-in -75.09, -44.89 64.25, 3.96 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -59.81, 122.21 APE9-dihe-in -122.18, 149.91 APE8-dihe-in -79.84, 97.02 APE8-rot-na 30.38 APE67-dihe-in -74.86, -3.8 -67.12, -38.73 APE12-dist-na 11.348 APE11-dist-na 10.353 APE10-dist-na 10.469 APE9-dist-in 6.649 None None None XRAY 2.7 0.198 0.232 A 331 306 4 0 0 2 [[712, 970]] 1.0 8tjl TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8HV2A 697 1019 1210.0 MWU:1101 Type1 Active DFGin 6.04 15.435 BLAminus -139.32, -173.88 59.04, 78.19 -91.93, 13.59 293.33, 98.36 -42.59, -32.3 in-in in 8.531 Saltbr-in 3.03 HRD-in -71.07, -46.84 65.82, -1.03 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.7, 109.65 APE9-dihe-in -131.83, 146.16 APE8-dihe-in -84.8, 103.81 APE8-rot-na 36.12 APE67-dihe-in -74.37, -12.04 -73.53, -33.32 APE12-dist-na 11.64 APE11-dist-na 10.242 APE10-dist-na 11.472 APE9-dist-in 6.978 None None None XRAY 2.8 0.179 0.216 A 331 299 8 0 0 5 [[712, 970]] 1.0 8hv2 TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7AEMA 695 1018 1210.0 6GY:1101 Type1 Active DFGin 6.131 14.377 BLAminus -127.32, -173.27 58.22, 82.35 -96.27, 28.52 299.39, 108.91 -62.1, -37.1 in-in in 8.638 Saltbr-in 2.804 HRD-in -54.09, -43.45 61.95, 3.78 in-in-in SNCiii in-in ActLoopNT-in 3.047 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.52, 113.41 APE9-dihe-in -117.42, 140.01 APE8-dihe-in -72.37, 110.57 APE8-rot-na 353.82 APE67-dihe-in -65.05, -21.43 -66.41, -39.04 APE12-dist-na 12.28 APE11-dist-na 9.798 APE10-dist-na 10.67 APE9-dist-in 6.31 None None None XRAY 2.65 0.199 0.221 A 346 312 2 0 0 0 [[712, 970]] 1.0 7aem TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2ITPA 697 1018 1210.0 AEE:2019 Type1 Active DFGin 5.862 14.646 BLAminus -129.98, -162.9 59.16, 79.47 -92.61, 9.17 298.14, 95.91 -39.72, -19.96 in-in in 8.075 Saltbr-in 2.967 HRD-in -64.35, -49.17 69.51, 1.0 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.58, 125.89 APE9-dihe-in -133.11, 143.15 APE8-dihe-in -86.75, 111.19 APE8-rot-na 34.96 APE67-dihe-in -68.3, -8.64 -72.28, -40.19 APE12-dist-na 11.875 APE11-dist-na 10.343 APE10-dist-na 11.0 APE9-dist-in 6.7 G719S None None XRAY 2.74 0.2 0.255 A 327 305 0 0 0 0 [[712, 970]] 1.0 2itp TYR_EGFR_HUMAN TYR 9.6e-87 296.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2ITQA 697 1018 1210.0 ITQ:2019 Type1 Active DFGin 6.078 15.164 BLAminus -134.28, -154.87 40.05, 86.95 -97.26, 14.78 286.7, 93.76 -49.66, -18.35 in-in in 8.212 Saltbr-in 2.496 HRD-in -68.58, -43.07 56.84, -0.76 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.75, 129.22 APE9-dihe-in -146.28, 133.97 APE8-dihe-in -72.77, 108.98 APE8-rot-na 28.27 APE67-dihe-in -74.85, -6.78 -74.35, -36.29 APE12-dist-na 12.367 APE11-dist-na 10.751 APE10-dist-na 10.745 APE9-dist-in 6.881 G719S None None XRAY 2.68 0.2 0.263 A 327 300 0 0 0 0 [[712, 970]] 1.0 2itq TYR_EGFR_HUMAN TYR 9.6e-87 296.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6S9DA 696 1017 1210.0 L3Z:61101 Type1 Active DFGin 5.692 14.454 BLAminus -145.84, -174.05 67.63, 80.79 -98.28, 29.08 296.6, 89.58 -65.8, -31.86 in-in in 8.44 Saltbr-in 2.714 HRD-in -67.01, -49.55 68.04, 12.84 in-in-in SNCiii in-in ActLoopNT-in 2.709 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.59, 131.77 APE9-dihe-in -121.94, 151.66 APE8-dihe-in -82.25, 75.56 APE8-rot-na 33.03 APE67-dihe-in -75.15, -10.02 -57.2, -40.45 APE12-dist-na 999.0 APE11-dist-na 11.155 APE10-dist-na 11.656 APE9-dist-in 7.189 T790M,L858R,E865A,E866A,K867A None None XRAY 2.67 0.195 0.224 A 329 298 13 0 0 11 [[712, 970]] 1.0 6s9d TYR_EGFR_HUMAN TYR 4.5e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5HIBA 696 1018 1210.0 63M:1101 Type1 Active DFGin 6.281 14.551 BLAminus -131.07, 178.91 58.54, 91.9 -106.97, 30.42 293.82, 89.04 -65.69, -27.27 in-in in 8.344 Saltbr-in 2.794 HRD-in -59.32, -46.04 66.52, -1.89 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.8, 112.15 APE9-dihe-in -114.46, 138.28 APE8-dihe-in -86.32, 78.33 APE8-rot-na 21.67 APE67-dihe-in -70.2, -2.29 -48.79, -44.91 APE12-dist-na 12.506 APE11-dist-na 11.364 APE10-dist-na 10.772 APE9-dist-in 7.181 T790M,L858R,E865A,E866A,K867A None None XRAY 2.85 0.197 0.239 A 331 314 5 0 0 5 [[712, 970]] 1.0 5hib TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4LQMA 697 1019 1210.0 DJK:1101 Type1 Active DFGin 5.979 14.54 BLAminus -148.3, -172.91 62.11, 72.19 -94.6, 21.41 296.71, 99.46 -60.17, -37.69 in-in in 8.219 Saltbr-in 2.831 HRD-in -68.88, -49.63 72.39, 3.25 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.81, 131.0 APE9-dihe-in -102.62, 141.96 APE8-dihe-in -82.36, 88.32 APE8-rot-na 26.08 APE67-dihe-in -70.52, -7.71 -65.57, -41.89 APE12-dist-na 999.0 APE11-dist-na 11.501 APE10-dist-na 12.101 APE9-dist-in 7.518 L858R None None XRAY 2.5 0.187 0.228 A 331 305 10 0 0 7 [[712, 970]] 1.0 4lqm TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7LGSA 702 984 1210.0 Q6K:61101 Type1 Active DFGin 5.798 13.848 BLAminus -148.14, -179.86 66.83, 93.39 -109.24, 25.55 296.83, 82.02 -45.71, -51.38 in-in in 8.254 Saltbr-in 2.914 HRD-in -61.85, -36.93 72.75, -6.16 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.14, 118.29 APE9-dihe-in -124.18, 152.07 APE8-dihe-in -87.87, 98.71 APE8-rot-na 33.29 APE67-dihe-in -76.07, 20.02 -59.01, -47.71 APE12-dist-na 10.735 APE11-dist-na 9.717 APE10-dist-na 10.441 APE9-dist-in 6.735 V948R None None XRAY 3.1 0.241 0.305 A 331 280 3 0 0 0 [[712, 970]] 1.0 7lgs TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7LGSB 702 984 1210.0 Q6K:62703 Type1 Active DFGin 6.065 14.132 BLAminus -143.64, 174.55 75.07, 86.01 -103.95, 23.76 297.26, 76.2 -47.19, -46.41 in-in in 8.489 Saltbr-in 2.925 HRD-in -70.84, -32.42 56.54, 26.28 in-in-in SNCiii in-in ActLoopNT-in 2.803 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.24, 133.4 APE9-dihe-in -137.17, 157.48 APE8-dihe-in -85.36, 106.29 APE8-rot-na 33.1 APE67-dihe-in -76.15, 7.94 -70.75, -39.01 APE12-dist-na 11.907 APE11-dist-na 9.426 APE10-dist-na 10.275 APE9-dist-in 6.571 V948R None None XRAY 3.1 0.241 0.305 B 331 283 0 0 0 0 [[712, 970]] 1.0 7lgs TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7LGSC 701 984 1210.0 Q6K:61101 Type1 Active DFGin 5.788 13.836 BLAminus -144.73, 172.67 64.73, 92.38 -102.97, 22.8 303.24, 82.51 -50.29, -34.49 in-in in 8.064 Saltbr-in 3.457 HRD-in -60.12, -39.38 78.78, -23.89 in-in-in SNCiii in-in ActLoopNT-in 3.202 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -145.58, 117.71 APE9-dihe-in -124.38, 146.08 APE8-dihe-in -62.99, 124.66 APE8-rot-na 21.56 APE67-dihe-in -104.68, 1.44 -87.08, -8.44 APE12-dist-na 11.582 APE11-dist-na 9.289 APE10-dist-na 9.921 APE9-dist-in 6.458 V948R None None XRAY 3.1 0.241 0.305 C 331 280 4 0 0 0 [[712, 970]] 1.0 7lgs TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7LGSD 701 984 1210.0 Q6K:62500 Type1 Active DFGin 5.717 14.024 BLAminus -133.47, 170.68 74.78, 90.52 -109.47, 24.05 298.1, 77.01 -64.19, -15.34 in-in in 8.201 Saltbr-in 2.786 HRD-in -55.31, -49.72 74.8, 6.32 in-in-in SNCiii in-in ActLoopNT-in 2.837 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.9, 130.33 APE9-dihe-in -138.85, 149.74 APE8-dihe-in -80.14, 110.14 APE8-rot-na 30.64 APE67-dihe-in -83.2, -1.33 -71.86, -29.25 APE12-dist-na 11.726 APE11-dist-na 9.543 APE10-dist-na 10.278 APE9-dist-in 6.353 V948R None None XRAY 3.1 0.241 0.305 D 331 276 8 0 0 0 [[712, 970]] 1.0 7lgs TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7T4JB 701 984 1210.0 R28:61101 Type1 Active DFGin 6.154 14.095 BLAminus -144.13, 179.52 58.61, 83.85 -92.13, 21.8 294.24, 75.73 -54.65, -26.76 in-in in 7.881 Saltbr-in 2.775 HRD-in -69.57, -54.49 84.7, -3.58 in-in-in SNCiii in-in ActLoopNT-in 2.806 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.5, 142.26 APE9-dihe-in -155.99, 150.11 APE8-dihe-in -82.77, 101.36 APE8-rot-na 36.83 APE67-dihe-in -75.7, -4.6 -67.21, -37.02 APE12-dist-na 11.913 APE11-dist-na 10.71 APE10-dist-na 10.255 APE9-dist-in 6.477 V948R None None XRAY 2.2 0.227 0.278 B 331 275 9 0 0 0 [[712, 970]] 1.0 7t4j TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4LRMA 696 999 1210.0 YUN:61101 Type1 Active DFGin 4.93 14.141 BLAminus -158.6, -179.81 59.5, 67.69 -73.3, -10.6 304.95, 80.93 -43.1, -43.98 in-in in 8.525 Saltbr-in 2.25 HRD-in -63.46, -47.09 80.09, -2.56 in-in-in SNCiii in-in ActLoopNT-in 3.48 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.95, 131.0 APE9-dihe-in -142.36, 158.24 APE8-dihe-in -79.28, 92.61 APE8-rot-na 26.9 APE67-dihe-in -59.89, -28.15 -57.58, -49.17 APE12-dist-na 9.439 APE11-dist-na 11.082 APE10-dist-na 9.688 APE9-dist-in 7.132 None None None XRAY 3.526 0.227 0.264 A 334 304 0 0 0 0 [[712, 970]] 1.0 4lrm TYR_EGFR_HUMAN TYR 1.7e-85 292.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4LRMB 695 984 1210.0 YUN:61101 Type1 Active DFGin 5.532 14.623 BLAminus -142.14, -169.88 61.38, 66.02 -84.65, 8.68 301.37, 83.75 -51.1, -43.11 in-in in 8.174 Saltbr-in 2.299 HRD-in -63.69, -44.58 74.58, 1.29 in-in-in SNCiii in-in ActLoopNT-in 3.42 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.16, 130.29 APE9-dihe-in -170.64, 141.47 APE8-dihe-in -73.49, 101.45 APE8-rot-na 22.26 APE67-dihe-in -63.2, -7.11 -64.86, -46.08 APE12-dist-na 10.44 APE11-dist-na 11.621 APE10-dist-na 9.395 APE9-dist-in 6.862 None None None XRAY 3.526 0.227 0.264 B 334 290 0 0 0 0 [[712, 970]] 1.0 4lrm TYR_EGFR_HUMAN TYR 1.7e-85 292.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4LRMC 694 983 1210.0 YUN:61101 Type1 Active DFGin 5.508 14.779 BLAminus -160.48, -176.43 59.92, 67.08 -79.93, -1.69 283.78, 100.07 -59.01, -39.57 in-in in 8.9 Saltbr-in 3.071 HRD-in -63.5, -47.73 78.4, -4.25 in-in-in SNCiii in-in ActLoopNT-in 3.24 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -126.48, 145.03 APE9-dihe-in -149.11, 167.52 APE8-dihe-in -81.81, 92.2 APE8-rot-na 26.63 APE67-dihe-in -60.5, -24.4 -61.07, -44.78 APE12-dist-na 10.454 APE11-dist-na 12.259 APE10-dist-na 11.083 APE9-dist-in 7.237 None None None XRAY 3.526 0.227 0.264 C 334 290 0 0 0 0 [[712, 970]] 1.0 4lrm TYR_EGFR_HUMAN TYR 1.7e-85 292.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4LRMD 696 981 1210.0 YUN:61101 Type1 Active DFGin 5.712 15.251 BLAminus -148.37, -162.17 52.48, 44.96 -64.79, -16.2 243.39, 79.15 -40.26, -53.82 in-in in 8.723 Saltbr-in 3.075 HRD-in -62.93, -45.84 76.67, -2.7 in-in-in SNCiii in-in ActLoopNT-in 3.103 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.87, 124.7 APE9-dihe-in -148.33, 129.49 APE8-dihe-in -84.5, 68.54 APE8-rot-na 31.24 APE67-dihe-in -68.57, -19.39 -40.54, -45.59 APE12-dist-na 9.638 APE11-dist-na 11.365 APE10-dist-na 8.404 APE9-dist-in 7.285 None None None XRAY 3.526 0.227 0.264 D 334 286 0 0 0 0 [[712, 970]] 1.0 4lrm TYR_EGFR_HUMAN TYR 1.7e-85 292.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4LRME 697 983 1210.0 YUN:61101 Type1 Active DFGin 5.122 15.128 BLAminus -149.12, 177.76 56.26, 51.42 -60.22, -36.0 278.23, 76.29 -54.0, 140.36 in-in in 8.548 Saltbr-in 2.983 HRD-in -64.42, -45.57 82.92, -8.54 in-in-in SNCiii in-in ActLoopNT-in 3.08 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -59.92, 140.02 APE9-dihe-in -130.51, 156.61 APE8-dihe-in -89.68, 108.31 APE8-rot-na 37.48 APE67-dihe-in -56.1, -15.47 -64.45, -45.1 APE12-dist-na 11.529 APE11-dist-na 9.116 APE10-dist-na 10.778 APE9-dist-in 6.782 None None None XRAY 3.526 0.227 0.264 E 334 287 0 0 0 0 [[712, 970]] 1.0 4lrm TYR_EGFR_HUMAN TYR 1.7e-85 292.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9U8CB 696 986 1210.0 A1L8T:61101 Type1 Active DFGin 5.714 14.383 BLAminus -153.52, -165.36 55.2, 60.65 -75.31, 21.07 288.54, 57.13 -53.37, -43.45 in-in in 8.847 Saltbr-in 3.157 HRD-in -114.61, -29.69 63.56, -60.39 in-in-in SNCiii in-in ActLoopNT-in 3.325 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.43, 125.24 APE9-dihe-in -148.34, 150.87 APE8-dihe-in -80.56, 88.11 APE8-rot-na 26.92 APE67-dihe-in -64.66, -40.79 -71.91, -41.96 APE12-dist-na 8.587 APE11-dist-na 11.025 APE10-dist-na 9.914 APE9-dist-in 7.586 None None None XRAY 3.5 0.275 0.3 B 338 288 3 0 0 0 [[712, 970]] 1.0 9u8c TYR_EGFR_HUMAN TYR 1.7e-85 292.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6JX0A 701 989 1210.0 YY3:1101,YY3:1102 Type1,Allosteric Active DFGin 5.62 14.181 BLAminus -159.3, -172.13 60.02, 72.45 -90.79, 10.95 286.73, 95.56 -60.06, -37.16 in-in in 8.691 Saltbr-in 2.665 HRD-in -72.92, -54.05 80.24, -1.58 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.1, 153.48 APE9-dihe-in -67.01, 145.59 APE8-dihe-in -63.12, 129.26 APE8-rot-na 333.49 APE67-dihe-in -73.75, -13.79 -61.59, -28.86 APE12-dist-na 9.471 APE11-dist-na 10.621 APE10-dist-na 11.287 APE9-dist-in 6.075 T790M None None XRAY 2.53 0.193 0.222 A 331 289 0 0 0 0 [[712, 970]] 1.0 6jx0 TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4G5JA 696 1016 1210.0 0WN:1101,0WM:1102,0WM:1103 Type1,Allosteric,Allosteric Active DFGin 5.661 14.178 BLAminus -144.89, -175.58 68.22, 78.3 -100.61, 32.3 302.5, 82.25 -64.26, -33.66 in-in in 8.275 Saltbr-in 3.481 HRD-in -67.78, -44.08 67.8, -6.86 in-in-in SNCiii in-in ActLoopNT-in 2.692 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.07, 126.93 APE9-dihe-in -140.25, 139.74 APE8-dihe-in -66.22, 118.21 APE8-rot-na 25.54 APE67-dihe-in -77.67, -2.62 -72.63, -33.57 APE12-dist-na 11.835 APE11-dist-na 9.614 APE10-dist-na 10.111 APE9-dist-in 6.279 None None None XRAY 2.8 0.208 0.259 A 330 307 14 0 0 0 [[712, 970]] 1.0 4g5j TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8D73A 703 1011 1210.0 QCR:1502 Type1.5_Back Active DFGin 5.396 14.639 BLAminus -137.39, -166.88 72.14, 68.63 -95.45, 13.53 294.58, 102.22 -51.07, -34.93 in-in in 8.48 Saltbr-in 2.899 HRD-in -72.18, -47.68 71.87, 13.91 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.59, 132.11 APE9-dihe-in -138.43, 150.74 APE8-dihe-in -80.34, 79.03 APE8-rot-na 34.01 APE67-dihe-in -74.66, -9.01 -47.69, -41.15 APE12-dist-na 12.506 APE11-dist-na 11.236 APE10-dist-na 11.277 APE9-dist-in 7.139 T790M,L858R,V948R None None XRAY 2.17 0.196 0.285 A 348 309 0 0 0 0 [[712, 970]] 1.0 8d73 TYR_EGFR_HUMAN TYR 7.7e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8D73B 704 1012 1210.0 QCR:1502 Type1.5_Back Active DFGin 5.395 14.65 BLAminus -137.92, -166.35 72.18, 68.71 -94.69, 12.26 295.76, 102.32 -51.71, -34.28 in-in in 8.446 Saltbr-in 2.911 HRD-in -71.23, -48.01 72.11, 12.51 in-in-in SNCiii in-in ActLoopNT-in 2.855 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.18, 131.42 APE9-dihe-in -139.31, 151.96 APE8-dihe-in -80.51, 78.64 APE8-rot-na 33.78 APE67-dihe-in -74.28, -9.24 -48.16, -40.87 APE12-dist-na 12.701 APE11-dist-na 11.364 APE10-dist-na 11.41 APE9-dist-in 7.222 T790M,L858R,V948R None None XRAY 2.17 0.196 0.285 B 348 309 0 0 0 0 [[712, 970]] 1.0 8d73 TYR_EGFR_HUMAN TYR 7.7e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8D76A 703 1014 1210.0 QFO:1504 Type1.5_Back Active DFGin 5.288 14.455 BLAminus -143.4, -172.03 76.83, 82.61 -101.19, 12.36 297.34, 100.87 -51.7, -27.33 in-in in 8.553 Saltbr-in 2.659 HRD-in -66.34, -53.39 73.14, 4.37 in-in-in SNCiii in-in ActLoopNT-in 2.838 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.29, 128.72 APE9-dihe-in -125.98, 143.72 APE8-dihe-in -74.29, 76.55 APE8-rot-na 33.63 APE67-dihe-in -70.33, -10.53 -49.4, -47.68 APE12-dist-na 12.407 APE11-dist-na 10.574 APE10-dist-na 11.338 APE9-dist-in 7.043 T790M,L858R,V948R None None XRAY 2.4 0.161 0.26 A 348 312 0 0 0 0 [[712, 970]] 1.0 8d76 TYR_EGFR_HUMAN TYR 7.7e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8D76B 702 1014 1210.0 QFO:1503 Type1.5_Back Active DFGin 5.243 14.516 BLAminus -142.04, -172.89 77.5, 81.63 -99.66, 12.37 297.26, 99.83 -52.91, -24.77 in-in in 8.564 Saltbr-in 2.654 HRD-in -65.39, -54.89 75.2, 3.17 in-in-in SNCiii in-in ActLoopNT-in 2.843 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.34, 127.65 APE9-dihe-in -127.49, 143.46 APE8-dihe-in -75.23, 77.39 APE8-rot-na 35.03 APE67-dihe-in -70.18, -10.99 -49.52, -47.15 APE12-dist-na 12.473 APE11-dist-na 10.719 APE10-dist-na 11.188 APE9-dist-in 7.049 T790M,L858R,V948R None None XRAY 2.4 0.161 0.26 B 348 313 0 0 0 0 [[712, 970]] 1.0 8d76 TYR_EGFR_HUMAN TYR 7.7e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9GL9A 696 1019 1210.0 A1IMT:61103 Type1.5_Back Active DFGin 6.134 14.351 BLAminus -126.96, -175.87 60.02, 86.56 -97.41, 25.27 289.91, 91.21 -60.54, -33.98 in-in in 8.369 Saltbr-in 2.935 HRD-in -68.5, -49.91 70.75, -1.83 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.17, 127.77 APE9-dihe-in -129.15, 139.26 APE8-dihe-in -73.46, 89.68 APE8-rot-na 31.97 APE67-dihe-in -69.08, -6.41 -52.73, -42.79 APE12-dist-na 11.768 APE11-dist-na 10.048 APE10-dist-na 10.634 APE9-dist-in 6.686 None None None XRAY 2.147 0.198 0.213 A 330 313 6 0 0 4 [[712, 970]] 1.0 9gl9 TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9FRDA 696 1019 1210.0 A1IEZ:61102 Type1.5_Back Active DFGin 6.155 14.189 BLAminus -125.51, -178.61 65.62, 88.15 -97.54, 20.94 286.3, 83.68 -59.21, -29.23 in-in in 8.202 Saltbr-in 2.761 HRD-in -72.5, -48.72 73.37, 1.71 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.9, 136.61 APE9-dihe-in -149.53, 130.81 APE8-dihe-in -64.36, 102.72 APE8-rot-na 338.2 APE67-dihe-in -74.18, -9.57 -63.44, -34.46 APE12-dist-na 12.068 APE11-dist-na 9.726 APE10-dist-na 10.278 APE9-dist-in 6.179 None None None XRAY 2.06 0.169 0.197 A 330 306 0 0 0 0 [[712, 970]] 1.0 9frd TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9GI9A 696 1018 1210.0 A1ILZ:1101 Type1.5_Back Active DFGin 5.846 13.826 BLAminus -132.78, -179.57 58.09, 96.13 -103.87, 37.89 296.85, 81.49 -65.94, -46.82 in-in in 7.886 Saltbr-in 2.987 HRD-in -78.91, -43.62 64.99, 17.27 in-in-in SNCiii in-in ActLoopNT-in 2.765 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.67, 120.08 APE9-dihe-in -139.61, 156.88 APE8-dihe-in -87.5, 103.35 APE8-rot-na 33.87 APE67-dihe-in -65.81, -24.28 -64.29, -41.89 APE12-dist-na 9.521 APE11-dist-na 10.15 APE10-dist-na 10.652 APE9-dist-in 6.635 None None None XRAY 3.12 0.192 0.248 A 330 308 7 0 0 7 [[712, 970]] 1.0 9gi9 TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8F1ZA 695 1018 1210.0 X9B:61101 Type1.5_Back Active DFGin 6.21 14.364 BLAminus -134.27, -179.34 59.56, 91.21 -108.92, 34.22 293.79, 82.15 -70.49, -26.69 in-in in 8.341 Saltbr-in 2.99 HRD-in -74.18, -45.61 69.12, 3.39 in-in-in SNCiii in-in ActLoopNT-in 2.958 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.23, 123.8 APE9-dihe-in -133.02, 144.23 APE8-dihe-in -69.28, 89.44 APE8-rot-na 26.79 APE67-dihe-in -74.18, 0.3 -61.08, -41.42 APE12-dist-na 12.229 APE11-dist-na 10.143 APE10-dist-na 10.615 APE9-dist-in 6.502 None None None XRAY 2.4 0.193 0.212 A 331 309 3 0 0 0 [[712, 970]] 1.0 8f1z TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9QXNAAA 696 1019 1210.0 A1JBI:61107 Type1.5_Back Active DFGin 6.174 14.286 BLAminus -130.22, -177.04 61.75, 91.16 -101.11, 22.36 284.94, 80.33 -60.14, -31.4 in-in in 8.367 Saltbr-in 2.953 HRD-in -68.76, -48.96 69.89, 3.72 in-in-in SNCiii in-in ActLoopNT-in 2.791 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.32, 133.52 APE9-dihe-in -138.05, 143.6 APE8-dihe-in -59.33, 99.88 APE8-rot-na 336.87 APE67-dihe-in -75.29, -7.57 -63.05, -36.41 APE12-dist-na 12.534 APE11-dist-na 9.376 APE10-dist-na 10.271 APE9-dist-in 6.122 None None None XRAY 2.142 0.158 0.21 AAA 346 322 2 0 0 0 [[712, 970]] 1.0 9qxn TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9DF2A 701 1004 1210.0 A1IMS:61101 Type1.5_Back Active DFGin 6.178 13.819 BLAminus -138.62, 178.98 67.62, 97.78 -114.22, 32.37 297.28, 88.95 -71.37, -22.63 in-in in 8.265 Saltbr-in 2.687 HRD-in -67.48, -51.99 72.72, 4.57 in-in-in SNCiii in-in ActLoopNT-in 2.943 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.21, 135.87 APE9-dihe-in -144.97, 152.75 APE8-dihe-in -81.03, 89.7 APE8-rot-na 33.51 APE67-dihe-in -75.91, -6.34 -54.41, -42.45 APE12-dist-na 12.562 APE11-dist-na 9.691 APE10-dist-na 10.529 APE9-dist-in 6.348 V948R None None XRAY 2.5 0.199 0.245 A 333 299 5 0 0 0 [[712, 970]] 1.0 9df2 TYR_EGFR_HUMAN TYR 6.3e-86 293.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9DF3A 701 1022 1210.0 A1IMS:61101 Type1.5_Back Active DFGin 6.12 14.079 BLAminus -133.91, -175.29 63.5, 92.21 -102.95, 27.03 288.2, 89.06 -60.61, -32.74 in-in in 8.449 Saltbr-in 2.779 HRD-in -72.11, -45.74 69.04, 1.04 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.71, 138.45 APE9-dihe-in -139.83, 153.3 APE8-dihe-in -82.59, 82.51 APE8-rot-na 33.21 APE67-dihe-in -70.96, -9.32 -51.24, -45.73 APE12-dist-na 12.319 APE11-dist-na 9.465 APE10-dist-na 10.087 APE9-dist-in 6.477 V948R None None XRAY 1.68 0.172 0.2 A 333 308 4 0 0 0 [[712, 970]] 1.0 9df3 TYR_EGFR_HUMAN TYR 5.8e-86 294.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9DF4A 701 1019 1210.0 A1A4E:61101 Type1.5_Back Active DFGin 6.014 14.12 BLAminus -131.08, -174.63 62.32, 93.34 -104.22, 25.37 287.03, 88.41 -63.45, -29.4 in-in in 8.345 Saltbr-in 2.86 HRD-in -71.66, -49.42 73.83, 0.52 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.63, 133.65 APE9-dihe-in -141.21, 156.63 APE8-dihe-in -83.85, 81.07 APE8-rot-na 31.86 APE67-dihe-in -75.41, -6.87 -50.13, -41.68 APE12-dist-na 12.353 APE11-dist-na 9.599 APE10-dist-na 10.119 APE9-dist-in 6.495 V948R None None XRAY 1.78 0.167 0.198 A 333 305 6 0 0 0 [[712, 970]] 1.0 9df4 TYR_EGFR_HUMAN TYR 5.8e-86 294.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9FQPA 701 1020 1210.0 A1IEZ:62001 Type1.5_Back Active DFGin 6.174 14.223 BLAminus -134.87, 178.52 66.55, 84.7 -99.61, 41.5 293.42, 84.34 -73.42, -44.6 in-in in 8.17 Saltbr-in 2.775 HRD-in -64.23, -41.66 63.86, 1.43 in-in-in SNCiii in-in ActLoopNT-in 3.029 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.72, 136.6 APE9-dihe-in -141.56, 152.91 APE8-dihe-in -81.25, 107.18 APE8-rot-na 26.8 APE67-dihe-in -71.04, -9.55 -68.38, -41.89 APE12-dist-na 12.347 APE11-dist-na 9.299 APE10-dist-na 9.942 APE9-dist-in 6.392 V948R None None XRAY 2.495 0.244 0.275 A 338 289 7 0 0 0 [[712, 970]] 1.0 9fqp TYR_EGFR_HUMAN TYR 1.3e-85 292.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9FQSA 701 1019 1210.0 A1IE0:61103 Type1.5_Back Active DFGin 6.134 14.192 BLAminus -132.91, -178.24 67.27, 86.84 -99.9, 25.54 296.52, 82.26 -59.0, -36.29 in-in in 8.617 Saltbr-in 2.89 HRD-in -69.4, -45.72 68.58, -3.7 in-in-in SNCiii in-in ActLoopNT-in 2.859 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.39, 137.92 APE9-dihe-in -140.19, 151.4 APE8-dihe-in -80.21, 88.89 APE8-rot-na 33.48 APE67-dihe-in -69.87, -7.88 -52.66, -46.03 APE12-dist-na 12.19 APE11-dist-na 9.316 APE10-dist-na 9.94 APE9-dist-in 6.4 V948R None None XRAY 1.783 0.199 0.237 A 338 302 5 0 0 0 [[712, 970]] 1.0 9fqs TYR_EGFR_HUMAN TYR 1.3e-85 292.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9GL7A 702 1019 1210.0 A1IMS:62001 Type1.5_Back Active DFGin 6.154 14.08 BLAminus -129.2, -177.57 64.25, 98.42 -114.09, 41.48 295.01, 81.54 -76.03, -38.0 in-in in 8.424 Saltbr-in 2.718 HRD-in -64.01, -43.17 64.53, -6.85 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.93, 136.43 APE9-dihe-in -141.98, 154.21 APE8-dihe-in -82.6, 89.72 APE8-rot-na 31.06 APE67-dihe-in -63.89, -13.13 -49.96, -51.09 APE12-dist-na 12.393 APE11-dist-na 9.644 APE10-dist-na 10.045 APE9-dist-in 6.468 V948R None None XRAY 1.878 0.269 0.287 A 338 297 7 0 0 0 [[712, 970]] 1.0 9gl7 TYR_EGFR_HUMAN TYR 1.3e-85 292.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9GL8A 701 1021 1210.0 A1IMT:61105 Type1.5_Back Active DFGin 6.109 14.327 BLAminus -129.76, -176.54 64.1, 87.88 -100.03, 29.35 290.94, 79.71 -65.82, -30.33 in-in in 8.352 Saltbr-in 2.821 HRD-in -68.18, -46.36 69.12, -2.54 in-in-in SNCiii in-in ActLoopNT-in 2.838 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.94, 136.71 APE9-dihe-in -136.26, 153.03 APE8-dihe-in -80.99, 80.94 APE8-rot-na 34.33 APE67-dihe-in -71.63, -8.89 -45.43, -47.1 APE12-dist-na 12.356 APE11-dist-na 9.463 APE10-dist-na 10.101 APE9-dist-in 6.473 V948R None None XRAY 1.632 0.189 0.224 A 338 305 5 0 0 0 [[712, 970]] 1.0 9gl8 TYR_EGFR_HUMAN TYR 1.3e-85 292.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3IKAA 696 1020 1210.0 0UN:1797 Type1 Inactive DFGin 5.778 14.354 ABAminus -126.08, -29.6 -103.63, 124.88 -119.83, 2.06 294.25, 104.41 -43.93, -35.44 in-in in 9.442 Saltbr-in 3.22 HRD-in -72.42, -49.2 76.65, -5.52 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.67, 130.5 APE9-dihe-in -133.91, 150.07 APE8-dihe-in -89.48, 105.4 APE8-rot-na 32.64 APE67-dihe-in -62.96, -1.82 -70.92, -51.09 APE12-dist-na 11.082 APE11-dist-na 9.128 APE10-dist-na 9.94 APE9-dist-in 6.742 T790M None None XRAY 2.9 0.21 0.257 A 331 310 0 0 0 0 [[712, 970]] 1.0 3ika TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7ER2A 697 1018 1210.0 JAU:1101 Type1 Inactive DFGin 6.121 14.754 ABAminus -129.03, -4.49 -116.2, 115.2 -116.5, 16.05 292.9, 93.99 -60.31, -21.65 in-in in 8.475 Saltbr-in 3.293 HRD-in -65.99, -41.99 69.27, -1.48 in-in-in SNCiii in-in ActLoopNT-in 2.975 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.01, 144.64 APE9-dihe-in -159.95, 159.85 APE8-dihe-in -81.99, 105.43 APE8-rot-na 34.36 APE67-dihe-in -79.1, 0.6 -66.2, -33.66 APE12-dist-na 11.353 APE11-dist-na 10.13 APE10-dist-na 10.437 APE9-dist-in 6.694 T790M,C797S None None XRAY 2.662 0.2 0.242 A 331 292 11 0 0 7 [[712, 970]] 1.0 7er2 TYR_EGFR_HUMAN TYR 3.3e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9XU9A 696 1020 1210.0 A1E1C:1101 Type1 Inactive DFGin 6.306 14.538 ABAminus -135.8, -11.71 -125.13, 122.43 -123.49, 11.83 295.92, 72.27 -41.05, -35.22 in-in in 8.55 Saltbr-in 2.355 HRD-in -67.87, -38.86 64.67, 9.16 in-in-in SNCiii in-in ActLoopNT-in 3.178 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.81, 167.85 APE9-dihe-in -153.48, 149.25 APE8-dihe-in -87.98, 89.05 APE8-rot-na 11.68 APE67-dihe-in -68.43, 5.48 -65.73, -47.64 APE12-dist-na 10.978 APE11-dist-na 10.272 APE10-dist-na 10.998 APE9-dist-in 7.228 T790M,C797S,L858R None None XRAY 2.84 0.235 0.294 A 331 310 0 0 0 0 [[712, 970]] 1.0 9xu9 TYR_EGFR_HUMAN TYR 6.6e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8KFQA 697 1018 1210.0 VUZ:1102 Type1 Inactive DFGin 6.072 14.965 ABAminus -141.13, -11.52 -105.63, 122.23 -124.79, 21.27 297.58, 119.18 -65.06, -1.37 in-in in 8.754 Saltbr-in 2.954 HRD-in -77.87, -49.16 73.66, -8.04 in-in-none SNCiin in-none ActLoopNT-in 3.086 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.18 APE8-dihe-in -86.32, 91.43 APE8-rot-na 34.26 APE67-dihe-in -70.0, -5.46 -70.66, -45.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.351 T790M,L858R None None XRAY 3.22 0.206 0.26 A 322 301 17 0 0 14 [[712, 970]] 1.0 8kfq TYR_EGFR_HUMAN TYR 8e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4LL0A 697 1017 1210.0 YUN:1101 Type1 Inactive DFGin 5.489 14.152 ABAminus -163.76, 69.81 -169.13, 137.16 -134.76, 14.68 278.24, 45.84 -54.76, -37.97 in-out in 9.387 Saltbr-out 3.655 HRD-in -66.16, -48.88 78.86, -10.91 out-in-none SNCoin in-none ActLoopNT-in 3.072 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.25 APE8-dihe-in -92.78, 86.64 APE8-rot-na 47.05 APE67-dihe-in -54.12, -27.22 -71.92, -41.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.806 T790M,L858R None None XRAY 4.0 0.238 0.257 A 331 291 13 0 0 13 [[712, 970]] 1.0 4ll0 TYR_EGFR_HUMAN TYR 8.7e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4LL0B 698 1017 1210.0 YUN:1101 Type1 Inactive DFGin 5.924 14.787 ABAminus -150.59, 21.7 -117.55, 135.66 -122.99, 27.75 263.81, 81.86 -54.7, -34.63 in-out in 9.396 Saltbr-out 3.705 HRD-in -65.09, -47.62 71.0, 0.04 out-in-none SNCoin in-none ActLoopNT-in 3.428 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.09 APE8-dihe-in -91.22, 86.34 APE8-rot-na 47.36 APE67-dihe-in -53.31, -28.09 -71.96, -41.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.712 T790M,L858R None None XRAY 4.0 0.238 0.257 B 331 281 14 0 0 14 [[712, 970]] 1.0 4ll0 TYR_EGFR_HUMAN TYR 8.7e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3VJNA 697 1018 1210.0 ANP:2001 ATPlike Inactive DFGin 6.07 15.553 BLAminus -140.47, -172.56 66.89, 81.42 -96.27, 22.36 285.26, 99.8 -61.68, -24.37 in-out in 8.864 Saltbr-out 4.159 HRD-in -62.92, -47.49 66.12, 0.14 out-in-in SNCoii in-in ActLoopNT-in 2.902 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.98, 116.83 APE9-dihe-in -113.71, 140.82 APE8-dihe-in -56.67, 106.47 APE8-rot-na 28.1 APE67-dihe-in -67.09, -6.37 -61.28, -43.59 APE12-dist-na 11.779 APE11-dist-na 9.748 APE10-dist-na 10.983 APE9-dist-in 5.988 G719S,T790M None None XRAY 2.34 0.197 0.244 A 334 297 4 0 0 0 [[712, 970]] 1.0 3vjn TYR_EGFR_HUMAN TYR 7.9e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8DSWA 696 1017 1210.0 ANP:61104 ATPlike Inactive DFGin 5.926 15.858 BLAminus -139.88, -174.48 62.3, 80.03 -97.39, 21.12 300.26, 86.52 -53.52, -37.16 none-none none 999.0 Saltbr-none 999.0 HRD-in -81.01, -46.59 69.43, -1.39 none-in-none SNCnin in-none ActLoopNT-in 2.921 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 105.32 APE8-dihe-in -90.45, 95.73 APE8-rot-na 32.83 APE67-dihe-in -75.5, -1.32 -70.5, -35.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.219 None None None XRAY 2.39 0.197 0.246 A 335 301 12 0 0 9 [[712, 970]] 1.0 8dsw TYR_EGFR_HUMAN TYR 1.9e-85 292.3 3 259 257 854 855 856 858 860 745 -9999 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3VJOA 696 1018 1210.0 ANP:2001 ATPlike Inactive DFGin 6.021 15.946 BLAminus -140.25, -165.5 56.51, 77.02 -90.26, 19.04 285.97, 94.98 -60.96, -7.67 in-out in 9.402 Saltbr-out 4.55 HRD-in -69.17, -43.62 63.06, 0.57 out-in-in SNCoii in-in ActLoopNT-in 2.921 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.49, 106.7 APE9-dihe-in -122.63, 146.56 APE8-dihe-in -79.91, 93.84 APE8-rot-na 34.61 APE67-dihe-in -67.26, -9.93 -59.74, -34.59 APE12-dist-na 12.246 APE11-dist-na 10.097 APE10-dist-na 10.762 APE9-dist-in 6.771 None None None XRAY 2.64 0.19 0.228 A 334 298 5 0 0 0 [[712, 970]] 1.0 3vjo TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2J5EA 696 1020 1210.0 No_ligand No_ligand Inactive DFGin 5.3 14.197 BLAminus -154.01, -164.58 53.42, 84.81 -101.82, 45.94 302.49, 103.79 -74.44, -25.77 in-in in 8.243 Saltbr-in 2.692 HRD-in -64.71, -41.39 67.57, -8.8 in-in-out SNCiio in-out ActLoopNT-in 2.731 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -155.15, 44.39 APE9-dihe-in -124.14, 139.7 APE8-dihe-in -60.02, 128.79 APE8-rot-na 337.65 APE67-dihe-in -78.62, -5.59 -70.62, -32.81 APE12-dist-na 12.086 APE11-dist-na 10.266 APE10-dist-na 8.878 APE9-dist-in 5.855 None None CY0797 XRAY 3.1 0.191 0.255 A 327 310 0 0 0 0 [[712, 970]] 1.0 2j5e TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2GS6A 696 1019 1210.0 No_ligand No_ligand Inactive DFGin 6.165 15.783 BLAminus -137.45, -165.85 53.49, 83.42 -103.4, 27.09 288.5, 89.52 -66.01, -11.62 in-out in 9.082 Saltbr-out 4.32 HRD-in -66.77, -39.61 61.96, 1.85 out-in-in SNCoii in-in ActLoopNT-in 2.898 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.14, 130.02 APE9-dihe-in -142.77, 141.16 APE8-dihe-in -66.85, 93.43 APE8-rot-na 36.58 APE67-dihe-in -61.45, -9.24 -52.09, -50.1 APE12-dist-na 11.797 APE11-dist-na 10.682 APE10-dist-na 10.788 APE9-dist-in 6.638 None None None XRAY 2.6 0.234 0.257 A 330 308 3 0 0 0 [[712, 970]] 1.0 2gs6 TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4WRGA 696 1019 1210.0 No_ligand No_ligand Inactive DFGin 6.122 15.603 BLAminus -132.42, -176.94 62.27, 81.51 -96.8, 20.71 293.04, 92.37 -69.52, -16.65 in-out in 9.35 Saltbr-out 3.876 HRD-in -77.59, -44.23 68.88, -0.09 out-in-none SNCoin in-none ActLoopNT-in 2.901 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 127.64 APE9-dihe-in -148.8, 140.64 APE8-dihe-in -74.11, 91.71 APE8-rot-na 32.62 APE67-dihe-in -71.26, -10.9 -55.8, -40.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.386 APE9-dist-in 6.499 None None CSX797 XRAY 1.9 0.198 0.212 A 330 288 14 0 0 2 [[712, 970]] 1.0 4wrg TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
1M14A 696 1020 1210.0 No_ligand No_ligand Inactive DFGin 6.201 15.306 BLAminus -137.1, -165.71 56.53, 80.64 -98.41, 22.57 294.1, 95.61 -65.31, -3.31 in-out in 9.033 Saltbr-out 3.771 HRD-in -62.63, -48.49 66.44, -3.16 out-in-out SNCoio in-out ActLoopNT-in 3.026 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -157.3, 26.59 APE9-dihe-in -89.14, 140.3 APE8-dihe-in -65.78, 113.03 APE8-rot-na 27.12 APE67-dihe-in -69.67, -4.11 -63.81, -35.78 APE12-dist-na 10.78 APE11-dist-na 11.168 APE10-dist-na 9.373 APE9-dist-in 5.819 None None None XRAY 2.6 0.24 0.286 A 333 307 0 0 0 0 [[712, 970]] 1.0 1m14 TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4R3PA 696 1018 1210.0 No_ligand No_ligand Inactive DFGin 5.794 15.362 BLAminus -146.93, -167.92 65.0, 63.51 -93.37, 28.92 304.52, 102.77 -64.06, -32.87 in-out in 9.911 Saltbr-out 4.377 HRD-in -66.42, -39.7 60.93, 7.56 out-in-in SNCoii in-in ActLoopNT-in 3.08 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.82, 134.31 APE9-dihe-in -132.8, 153.08 APE8-dihe-in -81.36, 84.64 APE8-rot-na 29.25 APE67-dihe-in -67.65, -19.01 -54.83, -43.42 APE12-dist-na 11.381 APE11-dist-na 10.366 APE10-dist-na 11.193 APE9-dist-in 7.071 L858R None None XRAY 2.905 0.211 0.24 A 323 310 0 0 0 0 [[712, 970]] 1.0 4r3p TYR_EGFR_HUMAN TYR 1e-86 296.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4R3RA 696 1018 1210.0 No_ligand No_ligand Inactive DFGin 6.0 15.992 BLAminus -140.36, -167.26 58.15, 75.69 -100.1, 23.09 295.5, 88.92 -63.04, -27.57 in-out in 9.903 Saltbr-out 4.453 HRD-in -73.6, -40.66 63.35, 7.22 out-in-in SNCoii in-in ActLoopNT-in 2.97 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.96, 127.4 APE9-dihe-in -131.84, 150.27 APE8-dihe-in -74.01, 79.15 APE8-rot-na 27.96 APE67-dihe-in -75.06, 5.66 -47.7, -49.04 APE12-dist-na 12.447 APE11-dist-na 11.005 APE10-dist-na 11.812 APE9-dist-in 7.243 L858R None None XRAY 3.25 0.201 0.247 A 323 309 1 0 0 0 [[712, 970]] 1.0 4r3r TYR_EGFR_HUMAN TYR 1e-86 296.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5CZHA 696 1018 1210.0 No_ligand No_ligand Inactive DFGin 5.944 16.518 BLAminus -151.23, -172.37 58.73, 69.38 -89.33, 12.08 284.98, 95.07 -57.88, -36.95 in-out in 9.729 Saltbr-out 3.779 HRD-in -65.41, -46.33 76.27, -1.32 out-in-in SNCoii in-in ActLoopNT-in 2.93 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.64, 136.83 APE9-dihe-in -139.66, 148.82 APE8-dihe-in -82.84, 83.54 APE8-rot-na 30.96 APE67-dihe-in -76.98, -0.11 -56.8, -41.38 APE12-dist-na 12.145 APE11-dist-na 9.949 APE10-dist-na 10.556 APE9-dist-in 7.075 L858R None None XRAY 2.8 0.193 0.22 A 331 311 0 0 0 0 [[712, 970]] 1.0 5czh TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5CZIA 696 1018 1210.0 No_ligand No_ligand Inactive DFGin 5.962 16.472 BLAminus -151.94, -175.87 60.47, 74.37 -93.41, 17.7 284.87, 92.98 -59.39, -35.75 out-out out 10.091 Saltbr-out 5.592 HRD-in -64.37, -47.77 77.54, -4.2 out-in-in SNCoii in-in ActLoopNT-in 2.942 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.78, 134.21 APE9-dihe-in -138.79, 149.63 APE8-dihe-in -81.85, 74.81 APE8-rot-na 31.34 APE67-dihe-in -78.0, 12.62 -42.86, -50.46 APE12-dist-na 12.214 APE11-dist-na 10.14 APE10-dist-na 10.86 APE9-dist-in 7.124 L858R None None XRAY 2.6 0.185 0.225 A 331 310 0 0 0 0 [[712, 970]] 1.0 5czi TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9U8CE 696 982 1210.0 No_ligand No_ligand Inactive DFGin 5.939 14.307 BLAminus -152.41, -164.62 56.58, 56.51 -76.81, 18.0 309.73, 156.49 -60.06, -44.31 in-none in 8.595 Saltbr-none 999.0 HRD-in -116.68, -28.07 63.68, -60.22 none-in-out SNCnio in-out ActLoopNT-in 3.179 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -163.89, -170.0 APE9-dihe-out 55.12, 162.48 APE8-dihe-out -88.45, 22.1 APE8-rot-na 35.32 APE67-dihe-out -64.59, -45.6 31.36, -60.68 APE12-dist-na 11.618 APE11-dist-na 9.599 APE10-dist-na 11.463 APE9-dist-out 8.563 None None None XRAY 3.5 0.275 0.3 E 338 287 0 0 0 0 [[712, 970]] 1.0 9u8c TYR_EGFR_HUMAN TYR 1.7e-85 292.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5XGNA 697 1020 1210.0 85X:1101 Type1 Inactive DFGin 5.582 13.644 BLAminus -153.26, 170.97 58.79, 71.97 -87.87, 19.38 306.48, 67.69 -60.62, -38.74 in-in in 8.847 Saltbr-in 2.822 HRD-in -68.76, -41.85 71.08, 4.38 in-in-out SNCiio in-out ActLoopNT-in 3.097 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -65.98, -39.97 APE9-dihe-in -71.67, 158.09 APE8-dihe-in -63.95, 139.95 APE8-rot-na 31.68 APE67-dihe-in -61.46, -41.98 -63.96, -39.37 APE12-dist-na 11.99 APE11-dist-na 9.853 APE10-dist-na 6.736 APE9-dist-in 5.774 T790M,C797S None None XRAY 3.0 0.222 0.251 A 331 302 0 0 0 0 [[712, 970]] 1.0 5xgn TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8EMEB 702 1007 1210.0 ZNL:1101 Type1 Inactive DFGin 6.136 12.914 BLAminus -133.84, 169.88 65.13, 69.02 -97.03, 123.1 348.61, 98.73 51.53, 999.0 out-out out 13.53 Saltbr-out 12.055 HRD-in -94.64, -53.18 73.04, -20.06 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 68.1 APE8-rot-na 28.3 APE67-dihe-in -72.67, -5.8 -55.65, -44.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 3.32 0.285 0.318 B 331 282 19 0 0 19 [[712, 970]] 1.0 8eme TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7A6IA 703 984 1210.0 R1W:1105 Type1 Inactive DFGin 5.438 15.201 BLAminus -139.42, -172.85 63.21, 85.24 -101.8, 27.35 298.55, 86.72 -65.73, -19.8 out-out out 10.522 Saltbr-out 4.139 HRD-in -70.13, -49.68 70.38, 6.04 out-in-out SNCoio in-out ActLoopNT-in 2.901 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.13, -14.58 APE9-dihe-in -89.01, 142.09 APE8-dihe-in -63.08, 128.71 APE8-rot-na 335.68 APE67-dihe-in -74.24, -4.43 -65.48, -25.25 APE12-dist-na 11.501 APE11-dist-na 10.628 APE10-dist-na 6.686 APE9-dist-in 4.925 T790M,V948R None None XRAY 2.4 0.204 0.239 A 333 282 0 0 0 0 [[712, 970]] 1.0 7a6i TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2JIUA 696 1016 1210.0 AEE:2017 Type1 Inactive DFGin 5.634 14.082 BLAminus -145.49, 179.31 63.52, 89.73 -108.67, 24.16 309.25, 93.65 -34.66, -27.93 in-out in 9.641 Saltbr-out 4.002 HRD-in -49.5, -61.5 85.29, -11.16 out-in-in SNCoii in-in ActLoopNT-in 3.445 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -95.44, 148.67 APE9-dihe-in -156.98, 144.14 APE8-dihe-in -91.11, 79.49 APE8-rot-na 27.16 APE67-dihe-in -68.15, 3.02 -38.52, -39.86 APE12-dist-na 11.717 APE11-dist-na 9.516 APE10-dist-na 10.218 APE9-dist-in 6.625 T790M None None XRAY 3.05 0.214 0.277 A 328 304 0 0 0 0 [[712, 970]] 1.0 2jiu TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5FEQA 697 1017 1210.0 5XH:1101 Type1 Inactive DFGin 6.502 15.107 BLAminus -131.66, -168.96 59.17, 85.25 -106.59, 25.28 290.32, 115.86 -66.06, -31.05 in-in in 8.3 Saltbr-in 3.09 HRD-in -58.87, -52.1 73.02, -13.69 in-in-out SNCiio in-out ActLoopNT-in 2.855 ActLoopCT-out TYR APEdihe_iioao APEdist_aaai APE10-dihe-in -92.25, 143.06 APE9-dihe-in -132.04, 157.2 APE8-dihe-out -53.9, -51.85 APE8-rot-na 333.25 APE67-dihe-out -72.26, -25.76 82.02, -51.56 APE12-dist-na 999.0 APE11-dist-na 10.248 APE10-dist-na 11.525 APE9-dist-in 7.17 T790M None None XRAY 3.4 0.17 0.222 A 328 290 10 0 0 5 [[712, 970]] 1.0 5feq TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5GMPA 696 1019 1210.0 F62:1101 Type1 Inactive DFGin 6.371 15.003 BLAminus -149.53, -179.31 60.35, 57.18 -88.01, 5.26 310.58, 112.94 -57.9, -38.1 in-in in 8.565 Saltbr-in 3.293 HRD-in -63.5, -41.57 61.77, -1.09 in-in-out SNCiio in-out ActLoopNT-in 2.613 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 150.95 APE8-dihe-in -84.68, 73.41 APE8-rot-na 32.34 APE67-dihe-in -63.78, -38.8 -63.92, -38.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.078 T790M None None XRAY 2.797 0.213 0.241 A 331 305 11 0 0 11 [[712, 970]] 1.0 5gmp TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5GTZA 697 1020 1210.0 81C:1101 Type1 Inactive DFGin 6.273 15.044 BLAminus -158.62, -172.16 60.32, 68.58 -94.78, 16.57 297.08, 118.19 -59.97, -37.98 in-in in 8.18 Saltbr-in 3.508 HRD-in -77.38, -45.78 71.04, -1.29 in-in-out SNCiio in-out ActLoopNT-in 2.748 ActLoopCT-out TYR APEdihe_nioao APEdist_aaai APE10-dihe-none 999.0, 169.8 APE9-dihe-in -135.97, 147.58 APE8-dihe-out -69.99, -39.44 APE8-rot-na 342.53 APE67-dihe-out -69.1, -30.25 74.68, -57.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.198 APE9-dist-in 7.834 T790M None None XRAY 2.999 0.191 0.23 A 331 317 7 0 0 7 [[712, 970]] 1.0 5gtz TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4WD5A 694 1021 1210.0 3LH:1101 Type1 Inactive DFGin 5.458 14.327 BLAminus -163.55, -174.21 53.25, 61.87 -88.09, 5.1 292.2, 106.75 -57.38, -39.62 out-out out 10.101 Saltbr-out 3.909 HRD-out -88.47, 107.17 -64.41, -38.01 out-in-out SNCoio in-out ActLoopNT-in 3.213 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -63.87, 132.32 APE9-dihe-in -145.35, 143.46 APE8-dihe-in -90.09, 123.82 APE8-rot-na 33.05 APE67-dihe-in -61.34, -40.63 -65.68, -40.65 APE12-dist-na 11.852 APE11-dist-na 9.456 APE10-dist-na 10.038 APE9-dist-out 8.073 T790M None None XRAY 3.3 0.211 0.239 A 331 307 0 0 0 0 [[712, 970]] 1.0 4wd5 TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3UG2A 697 1018 1210.0 IRE:1 Type1 Inactive DFGin 6.128 16.297 BLAminus -131.79, -168.85 59.62, 80.02 -93.0, 13.81 280.85, 97.63 -52.25, -28.71 in-out in 9.318 Saltbr-out 4.942 HRD-in -79.26, -48.84 71.4, -5.34 out-in-in SNCoii in-in ActLoopNT-in 2.912 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.39, 125.11 APE9-dihe-in -140.0, 141.56 APE8-dihe-in -80.99, 105.31 APE8-rot-na 37.43 APE67-dihe-in -66.78, -11.55 -70.88, -39.23 APE12-dist-na 11.844 APE11-dist-na 9.721 APE10-dist-na 10.858 APE9-dist-in 6.709 G719S,T790M None None XRAY 2.5 0.19 0.249 A 334 299 8 0 0 0 [[712, 970]] 1.0 3ug2 TYR_EGFR_HUMAN TYR 7.9e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9S3XA 696 1019 1210.0 A1JLU:1101 Type1 Inactive DFGin 5.898 15.374 BLAminus -132.89, -174.21 64.4, 85.9 -100.4, 11.48 285.57, 104.46 -52.15, -25.42 in-out in 8.752 Saltbr-out 3.953 HRD-in -71.92, -52.5 74.51, 0.04 out-in-in SNCoii in-in ActLoopNT-in 2.994 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -95.86, 101.54 APE9-dihe-in -118.22, 149.08 APE8-dihe-in -83.81, 77.9 APE8-rot-na 32.37 APE67-dihe-in -70.9, 0.06 -54.84, -44.82 APE12-dist-na 11.356 APE11-dist-na 11.364 APE10-dist-na 11.162 APE9-dist-in 7.085 None None None XRAY 2.423 0.192 0.246 A 324 324 0 0 0 0 [[712, 970]] 1.0 9s3x TYR_EGFR_HUMAN TYR 3.2e-86 294.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9D3VA 696 1019 1210.0 A1A5V:61101 Type1 Inactive DFGin 6.156 15.669 BLAminus -134.45, -170.65 71.87, 82.32 -100.43, 22.36 284.3, 100.25 -87.06, 2.75 in-in in 8.809 Saltbr-in 2.83 HRD-in -80.28, -49.34 80.85, -3.01 in-in-out SNCiio in-out ActLoopNT-in 2.795 ActLoopCT-out TYR APEdihe_ooiai APEdist_aaao APE10-dihe-out -143.14, 48.28 APE9-dihe-out -110.53, -27.12 APE8-dihe-in -80.27, 56.08 APE8-rot-na 30.72 APE67-dihe-in -74.59, -11.22 -58.28, -33.79 APE12-dist-na 5.37 APE11-dist-na 7.997 APE10-dist-na 10.755 APE9-dist-out 8.036 C797S,E865A,E866A,K867A None None XRAY 2.32 0.299 0.329 A 330 315 0 0 0 0 [[712, 970]] 1.0 9d3v TYR_EGFR_HUMAN TYR 3.5e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2ITWA 696 1018 1210.0 ITQ:2018 Type1 Inactive DFGin 5.853 15.473 BLAminus -142.09, -169.34 57.7, 89.5 -104.27, 29.57 295.26, 97.45 -82.52, 26.8 in-out in 9.115 Saltbr-out 3.924 HRD-in -65.22, -40.15 57.71, 1.3 out-in-in SNCoii in-in ActLoopNT-in 3.015 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -54.02, 133.84 APE9-dihe-in -142.1, 144.15 APE8-dihe-in -78.28, 106.03 APE8-rot-na 33.32 APE67-dihe-in -72.11, 0.73 -63.71, -37.22 APE12-dist-na 12.476 APE11-dist-na 10.833 APE10-dist-na 10.644 APE9-dist-in 6.454 None None None XRAY 2.88 0.191 0.256 A 327 301 0 0 0 0 [[712, 970]] 1.0 2itw TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9H46A 696 1019 1210.0 A1ISA:1101 Type1 Inactive DFGin 6.363 15.169 BLAminus -149.47, -177.58 62.62, 58.11 -90.1, 3.13 314.38, 111.86 -47.48, -44.04 in-in in 8.743 Saltbr-in 3.221 HRD-in -63.57, -45.69 65.43, -1.15 in-in-out SNCiio in-out ActLoopNT-in 2.657 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.98 APE8-dihe-in -85.78, 71.07 APE8-rot-na 35.5 APE67-dihe-in -68.16, -32.18 -60.78, -38.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.139 None None None XRAY 3.163 0.214 0.256 A 328 305 11 0 0 11 [[712, 970]] 1.0 9h46 TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4JQ7A 696 1019 1210.0 KJQ:61001 Type1 Inactive DFGin 5.766 14.947 BLAminus -142.56, -163.87 57.95, 63.34 -87.13, 23.58 297.46, 96.17 -62.25, -27.78 in-in in 8.568 Saltbr-in 2.764 HRD-in -72.72, -48.84 71.04, 5.2 in-in-out SNCiio in-out ActLoopNT-in 2.973 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 57.84, 54.36 APE9-dihe-in -113.81, 143.75 APE8-dihe-in -54.56, 110.74 APE8-rot-na 332.06 APE67-dihe-in -75.49, -11.01 -64.74, -36.9 APE12-dist-na 11.206 APE11-dist-na 10.439 APE10-dist-na 10.546 APE9-dist-in 6.043 None None None XRAY 2.73 0.208 0.237 A 328 303 0 0 0 0 [[712, 970]] 1.0 4jq7 TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4JQ8A 696 1019 1210.0 KJ8:61001 Type1 Inactive DFGin 5.802 14.534 BLAminus -152.56, -167.91 59.0, 68.71 -90.88, 39.65 318.01, 84.24 -67.29, -22.27 in-in in 8.77 Saltbr-in 2.669 HRD-in -62.97, -50.96 69.15, 4.05 in-in-out SNCiio in-out ActLoopNT-in 2.905 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 73.35, 63.7 APE9-dihe-in -115.81, 140.9 APE8-dihe-in -54.3, 111.45 APE8-rot-na 331.91 APE67-dihe-in -77.07, -6.6 -65.94, -34.63 APE12-dist-na 11.24 APE11-dist-na 10.155 APE10-dist-na 10.36 APE9-dist-in 5.794 None None None XRAY 2.83 0.186 0.232 A 328 303 0 0 0 0 [[712, 970]] 1.0 4jq8 TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4JR3A 696 1019 1210.0 KJR:61001 Type1 Inactive DFGin 5.761 15.075 BLAminus -140.13, -158.24 57.52, 55.13 -81.24, 25.3 299.15, 90.98 -63.61, -23.19 in-in in 8.725 Saltbr-in 2.799 HRD-in -73.26, -46.08 69.71, 7.12 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 61.6, 58.49 APE9-dihe-in -120.62, 144.52 APE8-dihe-in -57.7, 110.97 APE8-rot-na 334.09 APE67-dihe-in -75.24, -3.2 -70.93, -34.67 APE12-dist-na 11.014 APE11-dist-na 10.21 APE10-dist-na 10.405 APE9-dist-in 6.037 None None None XRAY 2.7 0.215 0.248 A 328 303 0 0 0 0 [[712, 970]] 1.0 4jr3 TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4JRVA 696 1019 1210.0 KJV:61001 Type1 Inactive DFGin 5.711 14.884 BLAminus -149.4, -166.43 54.55, 65.72 -84.05, 22.1 300.59, 98.04 -61.96, -15.57 in-in in 8.679 Saltbr-in 2.876 HRD-in -64.45, -49.37 72.67, 0.22 in-in-out SNCiio in-out ActLoopNT-in 2.939 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 59.5, 55.62 APE9-dihe-in -115.47, 148.63 APE8-dihe-in -62.21, 114.76 APE8-rot-na 334.99 APE67-dihe-in -77.09, -6.83 -72.28, -36.15 APE12-dist-na 12.193 APE11-dist-na 9.946 APE10-dist-na 10.21 APE9-dist-in 6.057 None None None XRAY 2.8 0.194 0.227 A 328 300 3 0 0 0 [[712, 970]] 1.0 4jrv TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8PNZA 695 1018 1210.0 2I0:1101 Type1 Inactive DFGin 6.01 15.383 BLAminus -127.34, -173.34 63.69, 76.51 -90.6, 17.7 292.67, 103.42 -61.2, -18.12 in-out in 8.997 Saltbr-out 3.994 HRD-in -66.3, -45.64 66.52, 2.69 out-in-in SNCoii in-in ActLoopNT-in 2.976 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.02, 110.59 APE9-dihe-in -113.33, 137.14 APE8-dihe-in -76.85, 91.84 APE8-rot-na 30.55 APE67-dihe-in -68.82, -7.15 -51.27, -45.51 APE12-dist-na 11.476 APE11-dist-na 9.801 APE10-dist-na 10.628 APE9-dist-in 6.571 None None None XRAY 2.51 0.229 0.284 A 329 311 2 0 0 0 [[712, 970]] 1.0 8pnz TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5JEBA 699 999 1210.0 6JS:61003 Type1 Inactive DFGin 5.405 13.673 BLAminus -139.58, -161.83 51.6, 77.22 -93.66, 22.71 298.5, 91.43 -63.19, -12.31 in-in in 8.515 Saltbr-in 2.555 HRD-in -75.13, -37.7 63.23, 2.32 in-in-out SNCiio in-out ActLoopNT-in 3.182 ActLoopCT-out TYR APEdihe_oioao APEdist_aaai APE10-dihe-out 60.87, 49.75 APE9-dihe-in -128.7, 148.47 APE8-dihe-out -58.38, -26.4 APE8-rot-na 13.7 APE67-dihe-out -62.13, -29.98 69.61, -49.65 APE12-dist-na 11.647 APE11-dist-na 11.403 APE10-dist-na 9.642 APE9-dist-in 6.241 V948R None None XRAY 3.298 0.244 0.27 A 337 299 2 0 0 0 [[712, 970]] 1.0 5jeb TYR_EGFR_HUMAN TYR 8.7e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
1M17A 696 1019 1210.0 AQ4:60999 Type1 Inactive DFGin 5.986 14.85 BLAminus -146.67, -165.67 54.04, 80.71 -94.47, 20.74 294.26, 91.25 -51.66, -26.88 in-in in 8.652 Saltbr-in 3.053 HRD-in -22.63, -70.63 76.83, 0.59 in-in-out SNCiio in-out ActLoopNT-in 3.228 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -142.06, 19.04 APE9-dihe-in -100.5, 138.82 APE8-dihe-in -68.53, 114.83 APE8-rot-na 28.55 APE67-dihe-in -70.29, 3.79 -62.89, -39.72 APE12-dist-na 11.13 APE11-dist-na 11.463 APE10-dist-na 8.606 APE9-dist-in 5.972 None None None XRAY 2.6 0.253 0.295 A 333 312 0 0 0 0 [[712, 970]] 1.0 1m17 TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8HY7A 696 1019 1210.0 NSO:1102 Type1 Inactive DFGin 6.61 15.259 BLAminus -143.68, -160.85 43.56, 82.0 -95.96, 31.22 296.84, 81.26 -64.67, -15.36 in-out in 8.353 Saltbr-out 4.947 HRD-in -76.66, -43.51 57.16, 15.85 out-in-none SNCoin in-none ActLoopNT-in 2.85 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.01 APE8-dihe-in -103.04, 85.55 APE8-rot-na 35.06 APE67-dihe-in -63.02, -5.07 -66.24, -45.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.503 E865A,E866A,K867A None None XRAY 2.91 0.198 0.251 A 330 299 18 0 0 14 [[712, 970]] 1.0 8hy7 TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6JRKA 696 1018 1210.0 C6O:1101 Type1 Inactive DFGin 6.151 15.687 BLAminus -133.54, -177.31 58.75, 61.62 -83.97, 49.61 313.83, 81.4 -63.76, -39.01 in-out in 8.7 Saltbr-out 4.094 HRD-in -79.02, -44.23 61.1, 3.96 out-in-none SNCoin in-none ActLoopNT-in 3.355 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 143.52 APE8-dihe-in -87.62, 79.08 APE8-rot-na 33.64 APE67-dihe-in -74.14, -9.21 -64.07, -35.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.413 E865A,E866A,K867A None None XRAY 2.796 0.2 0.236 A 331 283 23 0 0 15 [[712, 970]] 1.0 6jrk TYR_EGFR_HUMAN TYR 5.8e-87 297.3 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2ITUA 696 1019 1210.0 ITQ:2020 Type1 Inactive DFGin 6.271 15.627 BLAminus -134.44, -171.23 59.25, 91.54 -108.34, 5.63 292.29, 91.0 -53.91, 9.05 in-out in 9.044 Saltbr-out 3.774 HRD-in -68.49, -42.0 55.69, 2.63 out-in-none SNCoin in-none ActLoopNT-in 2.893 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.97 APE8-dihe-in -92.92, 81.72 APE8-rot-na 21.85 APE67-dihe-in -65.11, -0.4 -64.03, -44.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.666 L858R None None XRAY 2.8 0.201 0.258 A 327 304 10 0 0 10 [[712, 970]] 1.0 2itu TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2ITZA 697 1020 1210.0 IRE:2021 Type1 Inactive DFGin 5.737 14.231 BLAminus -131.03, -170.43 64.99, 76.02 -93.07, 24.13 302.2, 98.1 -48.52, -35.04 in-out in 8.129 Saltbr-out 3.634 HRD-in -66.91, -39.96 62.5, 6.79 out-in-none SNCoin in-none ActLoopNT-in 2.691 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 109.03 APE8-dihe-in -83.03, 97.62 APE8-rot-na 33.89 APE67-dihe-in -61.76, -16.39 -73.06, -45.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.389 L858R None None XRAY 2.8 0.205 0.255 A 327 303 10 0 0 10 [[712, 970]] 1.0 2itz TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6JWLA 696 1020 1210.0 YY3:1101 Type1 Inactive DFGin 6.268 15.147 BLAminus -148.94, -172.35 58.18, 67.62 -92.49, 12.45 290.61, 97.33 -59.59, -36.09 in-in in 8.293 Saltbr-in 2.972 HRD-in -73.51, -46.95 65.44, 11.82 in-in-out SNCiio in-out ActLoopNT-in 2.913 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 57.66, 41.1 APE9-dihe-in -69.1, 148.77 APE8-dihe-in -91.07, 95.73 APE8-rot-na 33.84 APE67-dihe-in -61.2, -38.42 -64.68, -39.82 APE12-dist-na 10.839 APE11-dist-na 11.973 APE10-dist-na 11.986 APE9-dist-in 7.609 L858R None None XRAY 2.551 0.208 0.242 A 331 319 6 0 0 6 [[712, 970]] 1.0 6jwl TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7T4JA 701 984 1210.0 R28:61101 Type1 Inactive DFGin 6.008 14.415 BLAminus -144.5, 169.5 68.77, 85.47 -96.42, 20.57 291.54, 77.61 -59.75, -25.89 in-in in 8.017 Saltbr-in 2.568 HRD-in -76.71, -52.5 81.16, 2.81 in-in-out SNCiio in-out ActLoopNT-in 2.877 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 45.96, 61.38 APE9-dihe-in -145.01, 131.44 APE8-dihe-in -84.06, 121.96 APE8-rot-na 31.03 APE67-dihe-in -61.46, 1.98 -82.97, -44.13 APE12-dist-na 11.773 APE11-dist-na 11.055 APE10-dist-na 8.533 APE9-dist-in 6.334 V948R None None XRAY 2.2 0.227 0.278 A 331 276 8 0 0 0 [[712, 970]] 1.0 7t4j TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8PO0A 695 1018 1210.0 2I6:61101 Type1 Inactive DFGin 5.565 15.802 BLAminus -122.92, -171.86 50.53, 59.02 -51.49, -62.41 283.3, 72.87 65.92, -46.76 in-none in 8.371 Saltbr-none 999.0 HRD-in -55.42, -36.9 57.38, 6.99 none-in-out SNCnio in-out ActLoopNT-in 3.012 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -134.75, 28.72 APE9-dihe-in -65.92, 135.7 APE8-dihe-in -64.04, 113.56 APE8-rot-na 21.15 APE67-dihe-in -56.75, -45.28 -67.59, -27.7 APE12-dist-na 11.771 APE11-dist-na 10.913 APE10-dist-na 11.645 APE9-dist-in 6.357 None None None XRAY 2.523 0.318 0.376 A 332 307 7 0 0 0 [[712, 970]] 1.0 8po0 TYR_EGFR_HUMAN TYR 1.6e-85 292.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9U8CA 696 989 1210.0 A1L8T:61101 Type1 Inactive DFGin 5.138 14.224 BLAminus -152.72, -166.88 55.62, 62.26 -74.1, 21.88 305.31, 73.74 -53.06, -42.51 in-out in 8.537 Saltbr-out 3.658 HRD-in -112.78, -28.58 64.39, -55.61 out-in-out SNCoio in-out ActLoopNT-in 3.308 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 63.95, 52.79 APE9-dihe-in -131.72, 146.15 APE8-dihe-in -83.5, 103.66 APE8-rot-na 25.73 APE67-dihe-in -64.45, -43.78 -72.16, -36.45 APE12-dist-na 12.368 APE11-dist-na 11.06 APE10-dist-na 8.394 APE9-dist-in 7.963 None None None XRAY 3.5 0.275 0.3 A 338 292 2 0 0 0 [[712, 970]] 1.0 9u8c TYR_EGFR_HUMAN TYR 1.7e-85 292.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9U8CC 696 980 1210.0 A1L8T:61101 Type1 Inactive DFGin 5.25 14.655 BLAminus -150.18, -166.33 56.37, 62.15 -74.03, 19.4 282.34, 71.74 -55.17, -41.51 in-out in 8.222 Saltbr-out 4.157 HRD-in -113.86, -26.91 64.43, -58.55 out-in-in SNCoii in-in ActLoopNT-in 3.3 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.57, 94.53 APE9-dihe-in -139.46, 143.63 APE8-dihe-in -83.28, 104.5 APE8-rot-na 28.04 APE67-dihe-in -65.21, -41.71 -68.24, -37.37 APE12-dist-na 8.664 APE11-dist-na 10.775 APE10-dist-na 8.429 APE9-dist-in 7.276 None None None XRAY 3.5 0.275 0.3 C 338 281 4 0 0 0 [[712, 970]] 1.0 9u8c TYR_EGFR_HUMAN TYR 1.7e-85 292.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4R5SA 697 1018 1210.0 FI3:1101 Type1.5_Back Inactive DFGin 5.101 14.574 BLAminus -157.2, -179.86 56.93, 47.29 -82.16, 60.06 358.48, 60.04 -65.03, -39.71 in-out in 9.457 Saltbr-out 4.992 HRD-in -64.01, -46.28 78.34, -4.7 out-in-out SNCoio in-out ActLoopNT-in 3.133 ActLoopCT-out TYR APEdihe_nnoao APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.94 APE8-dihe-out -63.79, -43.43 APE8-rot-na 31.31 APE67-dihe-out -60.79, -39.82 71.82, -57.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.805 L858R None None XRAY 3.001 0.209 0.239 A 331 299 9 0 0 9 [[712, 970]] 1.0 4r5s TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3W2OA 698 1017 1210.0 03P:61101 Type1.5_Front Inactive DFGin 6.063 16.853 BLAminus -136.96, -170.56 62.22, 87.75 -101.43, 18.89 291.4, 91.83 -57.44, -26.38 out-out out 10.675 Saltbr-out 8.523 HRD-in -77.47, -53.25 75.27, 2.22 out-in-in SNCoii in-in ActLoopNT-in 2.888 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.73, 104.36 APE9-dihe-in -123.36, 141.58 APE8-dihe-in -79.92, 73.45 APE8-rot-na 24.57 APE67-dihe-in -74.19, -6.86 -50.44, -40.99 APE12-dist-na 11.686 APE11-dist-na 11.26 APE10-dist-na 10.559 APE9-dist-in 7.223 T790M,L858R None None XRAY 2.35 0.182 0.216 A 331 304 0 0 0 0 [[712, 970]] 1.0 3w2o TYR_EGFR_HUMAN TYR 8.7e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3W2PA 698 1018 1210.0 W2P:61101 Type1.5_Front Inactive DFGin 6.166 17.253 BLAminus -131.72, -170.04 61.76, 87.11 -100.15, 22.27 288.83, 85.51 -59.78, -24.55 out-out out 10.896 Saltbr-out 9.197 HRD-in -74.33, -49.37 70.61, 3.25 out-in-in SNCoii in-in ActLoopNT-in 2.893 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -98.88, 109.86 APE9-dihe-in -115.54, 146.26 APE8-dihe-in -77.33, 72.71 APE8-rot-na 32.52 APE67-dihe-in -72.04, -9.29 -47.42, -44.04 APE12-dist-na 11.857 APE11-dist-na 11.036 APE10-dist-na 11.483 APE9-dist-in 7.134 T790M,L858R None None XRAY 2.05 0.181 0.206 A 331 307 0 0 0 0 [[712, 970]] 1.0 3w2p TYR_EGFR_HUMAN TYR 8.7e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3W2QA 698 1017 1210.0 HKI:61101 Type1.5_Front Inactive DFGin 6.184 16.72 BLAminus -130.59, -173.46 61.6, 82.75 -98.16, 22.05 287.41, 85.18 -65.26, -18.03 out-out out 10.536 Saltbr-out 5.753 HRD-in -77.64, -48.42 70.13, 4.48 out-in-in SNCoii in-in ActLoopNT-in 2.931 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.12, 121.01 APE9-dihe-in -124.15, 141.54 APE8-dihe-in -80.25, 75.51 APE8-rot-na 32.95 APE67-dihe-in -72.98, -8.46 -42.37, -46.09 APE12-dist-na 12.571 APE11-dist-na 10.333 APE10-dist-na 10.606 APE9-dist-in 7.01 T790M,L858R None None XRAY 2.2 0.177 0.2 A 331 306 0 0 0 0 [[712, 970]] 1.0 3w2q TYR_EGFR_HUMAN TYR 8.7e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2EB3A 696 1018 1210.0 ANP:2001 ATPlike Inactive DFGin 4.666 14.869 BLAplus -146.31, -170.86 55.73, 31.55 -96.53, 44.19 45.64, 108.62 -72.56, -59.05 in-in in 8.594 Saltbr-in 3.443 HRD-out -53.85, 138.27 -123.62, 23.93 in-in-none SNCiin in-none ActLoopNT-in 2.585 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 154.55 APE8-dihe-in -88.38, 74.74 APE8-rot-na 41.16 APE67-dihe-in -67.41, -11.07 -62.2, -31.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.893 None None None XRAY 2.84 0.19 0.236 A 334 294 15 0 0 14 [[712, 970]] 1.0 2eb3 TYR_EGFR_HUMAN TYR 1.2e-86 296.3 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5EDPA 697 1018 1210.0 No_ligand No_ligand Inactive DFGin 4.881 15.135 BLAplus -133.67, -173.57 50.41, 39.76 -96.85, 38.29 47.92, 89.07 -95.7, 31.38 in-in in 9.022 Saltbr-in 2.8 HRD-in -53.07, -59.18 77.76, -14.44 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 107.67 APE9-dihe-in -130.59, 131.78 APE8-dihe-in -87.86, 78.59 APE8-rot-na 23.14 APE67-dihe-in -63.28, -8.54 -48.69, -47.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.924 APE9-dist-in 7.511 T790M,L858R,E865A,E866A,K867A None None XRAY 2.9 0.202 0.244 A 331 295 17 0 0 15 [[712, 970]] 1.0 5edp TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5XGMA 696 1019 1210.0 85X:1101 Type1 Inactive DFGin 4.793 14.741 BLAplus -144.29, 167.69 73.25, 26.11 -72.78, -33.2 21.91, 88.3 -70.25, 109.4 in-in in 8.876 Saltbr-in 2.988 HRD-in -64.53, -47.15 68.98, -5.48 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 146.56 APE9-dihe-in -67.52, 143.4 APE8-dihe-in -85.81, 75.7 APE8-rot-na 32.24 APE67-dihe-in -60.03, -28.56 -62.99, -40.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.617 APE9-dist-out 8.502 T790M None None XRAY 2.952 0.204 0.232 A 331 288 20 0 0 16 [[712, 970]] 1.0 5xgm TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6JRJA 696 1018 1210.0 C6O:1101 Type1 Inactive DFGin 5.767 14.696 BLAplus -146.58, 171.3 63.59, 36.35 -83.45, 70.49 10.38, 12.45 -62.95, -40.46 in-out in 8.434 Saltbr-out 4.091 HRD-in -65.15, -46.37 77.52, -6.84 out-in-none SNCoin in-none ActLoopNT-in 3.374 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 39.25 APE8-rot-na 31.52 APE67-dihe-in -71.27, -25.91 -64.49, -36.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,C797S,E865A,E866A,K867A None None XRAY 2.943 0.207 0.246 A 331 288 19 0 0 15 [[712, 970]] 1.0 6jrj TYR_EGFR_HUMAN TYR 3.3e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5Y25A 698 1017 1210.0 8LU:61100 Type1 Inactive DFGin 5.072 15.24 BLAplus -135.07, -176.36 57.55, 57.43 -118.69, 40.35 43.37, 101.63 -71.29, -8.91 in-in in 9.165 Saltbr-in 2.935 HRD-in -62.19, -43.66 68.83, -3.95 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.04 APE8-dihe-in -99.62, 92.32 APE8-rot-na 24.61 APE67-dihe-in -66.0, -21.26 -68.05, -40.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.503 T790M,L858R None None XRAY 3.102 0.217 0.246 A 332 291 19 0 0 16 [[712, 970]] 1.0 5y25 TYR_EGFR_HUMAN TYR 8.8e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5EDRA 697 1018 1210.0 5N4:1101 Type1 Inactive DFGin 4.476 14.518 BLAplus -140.88, -176.91 54.86, 32.13 -91.81, -13.07 46.94, 81.82 -70.23, -16.55 in-in in 8.406 Saltbr-in 2.881 HRD-in -60.44, -58.52 79.57, -12.75 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.03 APE8-dihe-in -82.6, 73.37 APE8-rot-na 27.56 APE67-dihe-in -63.51, -16.69 -49.51, -47.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.483 T790M,L858R,E865A,E866A,K867A None None XRAY 2.6 0.192 0.215 A 331 299 18 0 0 16 [[712, 970]] 1.0 5edr TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5EM5A 697 1019 1210.0 5Q2:1101 Type1 Inactive DFGin 4.838 15.181 BLAplus -136.71, -176.75 58.33, 34.93 -98.56, 19.71 49.9, 87.47 -81.65, -7.27 in-in in 8.914 Saltbr-in 3.101 HRD-in -55.65, -58.2 76.7, -11.43 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.16 APE8-dihe-in -83.15, 78.58 APE8-rot-na 26.69 APE67-dihe-in -63.88, -8.73 -52.94, -46.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.728 T790M,L858R,E865A,E866A,K867A None None XRAY 2.65 0.213 0.223 A 331 298 20 0 0 16 [[712, 970]] 1.0 5em5 TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6TFUB 700 984 1210.0 N7K:1101 Type1.5_Back Inactive DFGin 5.089 13.784 BLAplus -138.35, -177.09 60.56, 54.11 -121.84, -30.08 55.57, 85.82 -88.61, 60.91 out-none out 13.449 Saltbr-none 999.0 HRD-in -75.19, -52.75 80.37, -17.47 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.89 APE8-dihe-in -74.28, 71.89 APE8-rot-na 29.18 APE67-dihe-in -75.39, -6.33 -57.09, -40.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.255 T790M,V948R None None XRAY 2.0 0.203 0.233 B 333 260 25 0 0 16 [[712, 970]] 1.0 6tfu TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5EDQA 697 1018 1210.0 5N3:1101 Type1.5_Back Inactive DFGin 4.744 14.666 BLAplus -140.42, 178.58 58.92, 32.84 -88.45, -6.6 42.16, 85.52 -82.15, 42.09 in-in in 8.508 Saltbr-in 2.903 HRD-in -61.82, -59.01 77.45, -15.01 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.42 APE8-dihe-in -88.64, 71.48 APE8-rot-na 24.56 APE67-dihe-in -66.17, -8.57 -52.55, -46.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.808 T790M,L858R,E865A,E866A,K867A None None XRAY 2.8 0.209 0.241 A 331 298 16 0 0 16 [[712, 970]] 1.0 5edq TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8A27A 701 985 1210.0 KY9:1102 Type3 Inactive DFGin 5.672 14.381 BLAplus -145.52, -178.77 57.22, 42.47 -100.42, -1.68 47.88, 94.3 -89.32, 20.08 out-out out 13.238 Saltbr-out 11.714 HRD-in -70.42, -54.97 75.01, -8.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.04 APE8-dihe-in -81.29, 59.61 APE8-rot-na 35.43 APE67-dihe-in -73.27, -7.01 -50.89, -40.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.484 None None None XRAY 1.07 0.126 0.16 A 326 269 16 0 0 16 [[712, 970]] 1.0 8a27 TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8A2AA 700 1019 1210.0 KY9:1101 Type3 Inactive DFGin 5.117 14.356 BLAplus -139.34, 175.57 57.42, 45.45 -97.33, -2.42 49.8, 85.36 -104.26, 24.72 out-out out 13.637 Saltbr-out 12.255 HRD-in -68.19, -54.53 72.52, -7.02 out-out-out SNCooo out-out ActLoopNT-out 6.62 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.68 APE8-dihe-in -79.56, 62.59 APE8-rot-na 33.47 APE67-dihe-in -77.17, -2.3 -52.5, -40.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.037 None None None XRAY 1.43 0.19 0.223 A 326 306 8 0 0 8 [[712, 970]] 1.0 8a2a TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXIC 700 1007 1210.0 8BS:1101 Type1 Inactive DFGin 7.177 14.411 BLBminus -132.91, 172.84 59.41, 71.0 -110.11, -162.74 349.91, 78.05 63.69, 999.0 out-out out 13.513 Saltbr-out 12.49 HRD-in -66.45, -56.15 77.12, -7.0 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.52 APE8-dihe-in -79.96, 70.34 APE8-rot-na 30.69 APE67-dihe-in -73.05, -5.2 -53.29, -45.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.533 T790M,V948R None None XRAY 3.0 0.278 0.312 C 331 283 21 0 0 18 [[712, 970]] 1.0 7jxi TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4RJ6A 697 1018 1210.0 3R0:1102 Type1 Inactive DFGin 5.322 14.423 BLBminus -136.99, -168.04 64.48, 79.04 -92.03, -167.17 304.29, 99.79 103.27, -12.3 in-in in 8.534 Saltbr-in 2.793 HRD-in -56.87, -52.67 70.63, 0.35 in-in-none SNCiin in-none ActLoopNT-in 3.033 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.81 APE8-dihe-in -85.67, 77.34 APE8-rot-na 21.98 APE67-dihe-in -69.76, -9.03 -50.07, -50.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.097 T790M,L858R,E865A,E866A,K867A None None XRAY 2.7 0.209 0.245 A 331 297 18 0 0 14 [[712, 970]] 1.0 4rj6 TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5EM6A 697 1019 1210.0 5Q3:1102 Type1.5_Back Inactive DFGin 5.878 14.145 BLBminus -133.39, -176.47 60.75, 93.41 -103.35, -152.41 296.39, 89.49 86.46, -35.52 in-in in 8.227 Saltbr-in 2.769 HRD-in -55.67, -47.22 65.49, -1.5 in-in-none SNCiin in-none ActLoopNT-in 2.851 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.38 APE8-dihe-in -86.72, 70.54 APE8-rot-na 29.24 APE67-dihe-in -70.1, -3.7 -44.09, -50.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.233 T790M,L858R,E865A,E866A,K867A None None XRAY 2.78 0.196 0.229 A 331 301 17 0 0 14 [[712, 970]] 1.0 5em6 TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8A2DA 701 1021 1210.0 KXY:1103 Type3 Inactive DFGin 6.285 15.539 BLBminus -141.89, -177.21 45.57, 75.85 -58.33, 149.05 294.71, 179.21 -62.78, 135.74 out-out out 13.017 Saltbr-out 10.523 HRD-in -72.83, -53.94 77.64, -5.69 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.3 APE8-dihe-in -76.96, 68.89 APE8-rot-na 35.24 APE67-dihe-in -71.59, -9.31 -48.88, -43.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.169 L858R,V948R None None XRAY 1.11 0.164 0.179 A 326 281 10 0 0 10 [[712, 970]] 1.0 8a2d TYR_EGFR_HUMAN TYR 8.1e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6P1LB 702 1008 1210.0 ANP:1102 ATPlike Inactive DFGin 4.326 15.477 BLBplus -134.87, 177.11 52.28, 41.66 -92.52, 151.37 118.41, 82.73 79.24, 7.39 out-out out 13.751 Saltbr-out 14.766 HRD-in -69.63, -50.82 67.27, 3.74 out-out-out SNCooo out-out ActLoopNT-out 8.694 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -67.98 APE8-dihe-in -90.55, 79.54 APE8-rot-na 36.74 APE67-dihe-in -76.92, -3.19 -66.82, -38.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.382 T790M,V948R None None XRAY 2.8 0.203 0.237 B 327 292 15 0 0 15 [[712, 970]] 1.0 6p1l TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6WAKA 702 1013 1210.0 ANP:1101 ATPlike Inactive DFGin 3.68 14.038 BLBplus -119.87, 174.58 64.54, 16.96 -69.25, 144.86 73.85, 86.13 77.2, -6.44 out-out out 14.19 Saltbr-out 14.87 HRD-in -68.06, -64.5 89.93, -15.8 out-out-out SNCooo out-out ActLoopNT-out 6.056 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -95.75, -0.13 APE9-dihe-in -104.56, 101.78 APE8-dihe-in -62.85, 69.07 APE8-rot-na 27.65 APE67-dihe-in -73.63, -8.28 -54.79, -35.95 APE12-dist-na 999.0 APE11-dist-na 15.624 APE10-dist-na 11.34 APE9-dist-in 7.772 T790M,V948R None None XRAY 2.4 0.219 0.23 A 328 297 10 0 0 10 [[712, 970]] 1.0 6wak TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6WAKD 701 1014 1210.0 ANP:1101 ATPlike Inactive DFGin 3.881 14.667 BLBplus -128.56, 164.59 71.9, 35.94 -89.47, 146.64 77.53, 95.38 87.93, -24.37 out-out out 13.753 Saltbr-out 11.845 HRD-in -75.5, -62.2 82.94, 0.35 out-out-out SNCooo out-out ActLoopNT-out 6.735 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.69 APE8-dihe-in -82.11, 67.25 APE8-rot-na 35.47 APE67-dihe-in -67.78, -4.44 -51.76, -45.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.046 T790M,V948R None None XRAY 2.4 0.219 0.23 D 328 297 17 0 0 14 [[712, 970]] 1.0 6wak TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8FV3A 701 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 3.96 13.397 BLBplus -132.16, 169.96 65.72, 32.0 -78.17, 140.3 56.84, 82.43 67.0, 6.27 out-out out 13.544 Saltbr-out 14.732 HRD-in -69.71, -62.71 86.1, -12.85 out-out-none SNCoon out-none ActLoopNT-out 6.542 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 27.23 APE9-dihe-in -63.25, 122.03 APE8-dihe-in -75.98, 67.82 APE8-rot-na 29.66 APE67-dihe-in -76.37, -3.74 -56.38, -36.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.726 APE9-dist-in 7.987 T790M,V948R None None XRAY 2.1 0.191 0.226 A 328 299 14 0 0 12 [[712, 970]] 1.0 8fv3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8FV4C 702 1013 1210.0 ANP:1102 ATPlike Inactive DFGin 4.082 13.558 BLBplus -127.73, 168.23 73.07, 11.78 -61.24, 145.82 61.45, 98.91 81.41, -31.2 out-out out 13.742 Saltbr-out 16.115 HRD-in -67.13, -63.64 88.26, -13.01 out-out-out SNCooo out-out ActLoopNT-out 6.584 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -45.21, -49.43 APE9-dihe-in -74.91, 126.99 APE8-dihe-in -76.17, 58.7 APE8-rot-na 28.97 APE67-dihe-in -74.88, -4.9 -52.62, -40.92 APE12-dist-na 999.0 APE11-dist-na 16.262 APE10-dist-na 12.232 APE9-dist-out 8.1 T790M,V948R None None XRAY 2.2 0.204 0.261 C 328 296 11 0 0 11 [[712, 970]] 1.0 8fv4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8TO3B 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 3.657 14.934 BLBplus -134.55, 162.66 68.08, 49.36 -93.73, 164.43 101.15, 105.54 56.1, 2.84 out-out out 13.767 Saltbr-out 13.971 HRD-in -68.15, -46.1 73.95, -11.19 out-out-out SNCooo out-out ActLoopNT-out 6.842 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 106.24 APE8-dihe-in -74.12, 71.61 APE8-rot-na 27.49 APE67-dihe-in -65.2, -1.6 -53.66, -41.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.13 T790M,V948R None None XRAY 2.49 0.231 0.269 B 328 291 18 0 0 13 [[712, 970]] 1.0 8to3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8TO4B 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 4.321 13.838 BLBplus -145.22, 172.21 45.08, 44.37 -91.4, 153.78 67.05, 82.38 64.94, 7.17 out-out out 14.011 Saltbr-out 13.48 HRD-in -63.39, -70.27 96.97, -15.43 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.51 APE8-dihe-in -77.84, 67.96 APE8-rot-na 10.85 APE67-dihe-in -65.93, -24.75 -51.27, -47.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.537 T790M,V948R None None XRAY 2.99 0.176 0.231 B 328 290 18 0 0 14 [[712, 970]] 1.0 8to4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4ZSED 701 1015 1210.0 ANP:4001 ATPlike Inactive DFGin 4.481 13.699 BLBplus -139.61, 164.7 66.53, 26.19 -71.23, 138.48 53.66, 91.47 74.43, 7.23 out-out out 13.877 Saltbr-out 13.686 HRD-in -70.41, -53.51 80.03, -13.83 out-out-none SNCoon out-none ActLoopNT-out 6.522 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.0 APE8-dihe-in -83.67, 68.18 APE8-rot-na 28.71 APE67-dihe-in -64.05, -23.47 -60.9, -39.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.989 T790M,V948R None None XRAY 1.97 0.191 0.213 D 331 297 14 0 0 12 [[712, 970]] 1.0 4zse TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5D41B 701 1014 1210.0 ANP:2001 ATPlike Inactive DFGin 3.946 14.283 BLBplus -122.59, 173.39 56.77, 40.3 -84.43, 150.38 61.52, 86.97 79.88, -36.14 out-out out 13.666 Saltbr-out 11.144 HRD-in -72.27, -56.38 80.95, -10.72 out-out-out SNCooo out-out ActLoopNT-out 6.673 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -30.97 APE9-dihe-in -100.3, 124.18 APE8-dihe-in -72.86, 61.7 APE8-rot-na 30.04 APE67-dihe-in -79.76, 0.67 -51.2, -39.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.501 APE9-dist-out 8.352 T790M,V948R None None XRAY 2.31 0.175 0.207 B 331 302 12 0 0 12 [[712, 970]] 1.0 5d41 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5X2AD 701 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 4.567 13.491 BLBplus -132.47, 164.02 73.22, 18.47 -66.23, 142.03 48.39, 91.71 77.4, 1.26 out-out out 13.992 Saltbr-out 14.35 HRD-in -72.94, -56.49 82.37, -10.91 out-out-out SNCooo out-out ActLoopNT-out 6.463 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 3.06 APE9-dihe-in -69.62, 129.82 APE8-dihe-in -83.4, 65.28 APE8-rot-na 22.72 APE67-dihe-in -72.49, -3.02 -53.67, -40.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.897 APE9-dist-out 8.235 T790M,V948R None None XRAY 1.85 0.176 0.219 D 331 297 13 0 0 10 [[712, 970]] 1.0 5x2a TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXKB 700 1007 1210.0 ANP:1101 ATPlike Inactive DFGin 4.788 14.304 BLBplus -133.99, 169.66 58.32, 39.23 -93.88, 160.42 49.41, 87.38 74.89, 999.0 out-out out 13.49 Saltbr-out 12.394 HRD-in -66.37, -58.14 81.2, -5.32 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.52 APE8-dihe-in -80.54, 72.01 APE8-rot-na 30.24 APE67-dihe-in -73.85, -4.26 -53.45, -45.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.541 T790M,V948R None None XRAY 3.1 0.223 0.261 B 331 290 18 0 0 18 [[712, 970]] 1.0 7jxk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXMC 702 1006 1210.0 ANP:1101 ATPlike Inactive DFGin 4.283 13.994 BLBplus -133.09, 168.24 59.36, 33.1 -80.78, 143.72 58.15, 87.09 66.36, 74.02 out-out out 13.963 Saltbr-out 13.118 HRD-in -67.9, -61.75 83.53, -6.82 out-out-none SNCoon out-none ActLoopNT-out 9.008 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.47 APE8-dihe-in -77.6, 66.96 APE8-rot-na 35.92 APE67-dihe-in -75.2, -5.27 -47.14, -42.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.517 T790M,V948R None None XRAY 2.192 0.228 0.271 C 331 285 20 0 0 15 [[712, 970]] 1.0 7jxm TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5CNOB 698 1015 1210.0 ANP:61001 ATPlike Inactive DFGin 3.889 14.151 BLBplus -128.77, 161.65 68.19, 38.17 -78.09, 143.32 56.13, 92.23 54.89, 36.11 out-out out 13.877 Saltbr-out 12.607 HRD-in -79.53, -48.18 74.57, -9.86 out-out-out SNCooo out-out ActLoopNT-out 8.188 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 114.62 APE9-dihe-in -83.89, 124.6 APE8-dihe-in -81.17, 61.86 APE8-rot-na 30.73 APE67-dihe-in -73.98, -7.26 -47.13, -40.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.092 APE9-dist-out 8.401 V948R None None XRAY 1.55 0.176 0.203 B 330 302 16 0 0 12 [[712, 970]] 1.0 5cno TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5CNNA 699 1014 1210.0 ANP:61101 ATPlike Inactive DFGin 3.97 14.17 BLBplus -125.09, 165.12 65.79, 30.65 -73.26, 142.49 57.23, 92.2 61.04, 28.88 out-out out 14.419 Saltbr-out 11.397 HRD-in -77.1, -52.71 74.61, -9.55 out-out-none SNCoon out-none ActLoopNT-out 8.169 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 61.56 APE9-dihe-in -85.48, 136.67 APE8-dihe-in -75.32, 67.13 APE8-rot-na 28.89 APE67-dihe-in -79.02, -2.66 -49.07, -38.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.997 APE9-dist-in 7.994 I706Q None None XRAY 1.9 0.183 0.211 A 350 300 16 0 0 13 [[712, 970]] 1.0 5cnn TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6P1DB 702 1013 1210.0 ANP:1101,NQ1:1102 ATPlike,Type3 Inactive DFGin 4.737 14.03 BLBplus -133.29, 171.5 64.7, 17.77 -68.3, 145.06 52.12, 92.58 81.65, -14.38 out-out out 13.79 Saltbr-out 14.416 HRD-in -75.11, -58.04 81.02, -12.96 out-out-out SNCooo out-out ActLoopNT-out 6.39 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -53.71 APE8-dihe-in -78.39, 61.97 APE8-rot-na 34.06 APE67-dihe-in -73.46, -6.67 -54.96, -43.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.356 None None None XRAY 2.4 0.195 0.213 B 327 300 12 0 0 12 [[712, 970]] 1.0 6p1d TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6P1LA 701 1007 1210.0 ANP:1102,9LL:1103 ATPlike,Type3 Inactive DFGin 5.09 14.609 BLBplus -137.99, 174.26 51.86, 38.49 -97.68, 160.33 56.12, 79.32 80.95, 13.49 out-out out 13.09 Saltbr-out 11.075 HRD-in -66.81, -53.87 69.64, 3.15 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.91 APE8-dihe-in -92.34, 76.37 APE8-rot-na 35.99 APE67-dihe-in -76.25, -4.78 -68.05, -35.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.361 T790M,V948R None None XRAY 2.8 0.203 0.237 A 327 288 19 0 0 17 [[712, 970]] 1.0 6p1l TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6P1LC 702 1005 1210.0 ANP:1102,9LL:1103 ATPlike,Type3 Inactive DFGin 4.947 14.346 BLBplus -138.12, 175.57 52.19, 39.44 -97.35, 162.11 56.76, 79.57 81.63, 13.51 out-out out 13.069 Saltbr-out 12.69 HRD-in -65.46, -53.47 68.76, 3.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -21.1 APE8-dihe-in -91.14, 76.85 APE8-rot-na 36.16 APE67-dihe-in -74.42, -4.16 -69.53, -34.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.035 T790M,V948R None None XRAY 2.8 0.203 0.237 C 327 280 24 0 0 17 [[712, 970]] 1.0 6p1l TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6P1LD 702 1015 1210.0 ANP:1102,9LL:1103 ATPlike,Type3 Inactive DFGin 5.193 14.634 BLBplus -136.45, 175.46 51.75, 39.49 -96.95, 158.96 56.24, 81.53 81.72, 11.0 out-out out 13.155 Saltbr-out 10.982 HRD-in -66.43, -53.42 65.79, 5.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.86 APE8-dihe-in -92.75, 77.55 APE8-rot-na 35.81 APE67-dihe-in -75.19, -4.23 -67.58, -35.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.094 T790M,V948R None None XRAY 2.8 0.203 0.237 D 327 296 17 0 0 17 [[712, 970]] 1.0 6p1l TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6P8QA 699 1019 1210.0 ANP:2001,O57:2002 ATPlike,Type3 Inactive DFGin 5.291 14.467 BLBplus -136.39, 166.39 65.62, 19.67 -68.64, 141.86 47.45, 96.29 88.91, -15.41 out-out out 13.793 Saltbr-out 13.394 HRD-in -77.48, -60.3 86.7, -15.68 out-out-none SNCoon out-none ActLoopNT-out 6.927 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.69 APE8-dihe-in -82.28, 70.48 APE8-rot-na 31.78 APE67-dihe-in -69.54, -10.7 -59.7, -40.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.523 T790M,V948R None None XRAY 1.9 0.169 0.195 A 327 309 12 0 0 12 [[712, 970]] 1.0 6p8q TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6P8QB 698 1007 1210.0 AMP:2001,O57:2002 ATPlike,Type3 Inactive DFGin 5.276 14.467 BLBplus -135.86, 166.31 67.07, 15.83 -64.3, 136.34 50.27, 96.09 85.52, -9.82 out-out out 13.54 Saltbr-out 13.7 HRD-in -74.24, -59.24 89.14, -20.92 out-out-none SNCoon out-none ActLoopNT-out 6.974 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 150.09 APE9-dihe-in -104.23, 113.6 APE8-dihe-in -82.27, 71.52 APE8-rot-na 22.76 APE67-dihe-in -69.35, -13.24 -58.74, -40.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.877 APE9-dist-in 7.993 T790M,V948R None None XRAY 1.9 0.169 0.195 B 327 300 10 0 0 10 [[712, 970]] 1.0 6p8q TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6P8QC 699 1014 1210.0 AMP:2001,O57:2002 ATPlike,Type3 Inactive DFGin 5.309 14.59 BLBplus -130.27, 166.7 65.36, 18.32 -66.06, 140.33 49.17, 97.15 81.91, -12.21 out-out out 13.83 Saltbr-out 13.591 HRD-in -81.24, -59.54 87.32, -15.78 out-out-in SNCooi out-in ActLoopNT-out 6.911 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.57, 147.96 APE9-dihe-in -130.06, 156.46 APE8-dihe-in -83.94, 74.96 APE8-rot-na 27.22 APE67-dihe-in -70.93, -14.87 -56.96, -36.77 APE12-dist-na 16.927 APE11-dist-na 13.676 APE10-dist-na 14.094 APE9-dist-in 7.721 T790M,V948R None None XRAY 1.9 0.169 0.195 C 327 316 0 0 0 0 [[712, 970]] 1.0 6p8q TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6P8QD 700 1007 1210.0 AMP:2001,O57:2002 ATPlike,Type3 Inactive DFGin 5.367 14.316 BLBplus -131.89, 166.57 70.0, 15.99 -68.19, 140.48 43.77, 99.15 83.83, -10.13 out-out out 13.426 Saltbr-out 13.149 HRD-in -73.29, -58.03 87.0, -17.51 out-out-none SNCoon out-none ActLoopNT-out 6.894 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 92.37 APE8-dihe-in -76.46, 76.63 APE8-rot-na 30.25 APE67-dihe-in -71.2, -11.99 -56.02, -38.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.449 T790M,V948R None None XRAY 1.9 0.169 0.195 D 327 296 12 0 0 12 [[712, 970]] 1.0 6p8q TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6XL4D 700 1013 1210.0 ANP:1102,NQ1:1103 ATPlike,Type3 Inactive DFGin 4.89 14.247 BLBplus -133.2, 175.82 65.76, 18.85 -77.15, 145.6 52.8, 92.59 74.56, -2.19 out-out out 13.624 Saltbr-out 15.83 HRD-in -71.69, -57.79 76.59, -4.88 out-out-none SNCoon out-none ActLoopNT-out 6.478 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.17 APE8-dihe-in -78.79, 71.74 APE8-rot-na 31.74 APE67-dihe-in -74.38, -1.99 -55.71, -41.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.77 T790M,V948R None None XRAY 2.06 0.216 0.252 D 328 300 14 0 0 11 [[712, 970]] 1.0 6xl4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8TO4C 702 1013 1210.0 ANP:1102,IXR:1103 ATPlike,Type3 Inactive DFGin 5.324 14.703 BLBplus -141.27, 171.12 64.77, 53.38 -109.59, 167.64 42.74, 100.72 59.4, 999.0 out-out out 13.294 Saltbr-out 12.35 HRD-in -63.29, -59.94 84.01, 4.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.05 APE8-dihe-in -90.09, 61.93 APE8-rot-na 21.85 APE67-dihe-in -81.47, -6.07 -53.96, -24.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.836 T790M,V948R None None XRAY 2.99 0.176 0.231 C 328 289 18 0 0 18 [[712, 970]] 1.0 8to4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8TO4D 702 1005 1210.0 ANP:1102,IXR:1103 ATPlike,Type3 Inactive DFGin 4.551 14.188 BLBplus -127.27, 157.13 78.08, 44.22 -85.23, -172.29 38.08, 100.01 106.69, 999.0 out-out out 13.656 Saltbr-out 10.825 HRD-in -72.87, -44.75 69.45, -7.84 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 105.73 APE8-dihe-in -81.92, 60.79 APE8-rot-na 34.7 APE67-dihe-in -66.67, -11.33 -39.66, -48.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.66 T790M,V948R None None XRAY 2.99 0.176 0.231 D 328 283 20 0 0 18 [[712, 970]] 1.0 8to4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5D41A 698 1014 1210.0 ANP:1102,57N:1103 ATPlike,Type3 Inactive DFGin 4.968 14.448 BLBplus -130.27, 169.23 61.95, 37.88 -93.29, 173.71 50.74, 86.35 79.65, -10.55 out-out out 12.815 Saltbr-out 11.374 HRD-in -77.25, -55.76 78.51, -14.31 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 155.57 APE8-dihe-in -80.12, 74.82 APE8-rot-na 31.53 APE67-dihe-in -75.45, -3.11 -51.46, -43.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8 T790M,V948R None None XRAY 2.31 0.175 0.207 A 331 300 17 0 0 17 [[712, 970]] 1.0 5d41 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6DUKA 701 1006 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.416 14.801 BLBplus -133.89, 165.03 66.94, 37.08 -93.36, 166.29 58.42, 86.37 91.91, 6.11 out-out out 13.918 Saltbr-out 14.179 HRD-in -76.73, -64.87 85.37, -18.97 out-out-out SNCooo out-out ActLoopNT-out 7.438 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.39, -10.84 APE9-dihe-in -125.5, 116.79 APE8-dihe-in -80.16, 76.04 APE8-rot-na 31.69 APE67-dihe-in -76.14, -1.34 -58.18, -44.83 APE12-dist-na 17.364 APE11-dist-na 15.202 APE10-dist-na 11.776 APE9-dist-in 7.311 T790M,V948R None None XRAY 2.2 0.191 0.223 A 331 306 0 0 0 0 [[712, 970]] 1.0 6duk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6DUKB 699 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.681 14.65 BLBplus -136.44, 165.42 61.83, 36.22 -89.54, 161.73 53.44, 89.67 90.48, 19.39 out-out out 13.812 Saltbr-out 14.733 HRD-in -68.48, -61.78 82.94, -15.18 out-out-none SNCoon out-none ActLoopNT-out 7.292 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.53 APE8-dihe-in -76.17, 63.91 APE8-rot-na 26.99 APE67-dihe-in -79.83, -2.27 -51.77, -41.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.922 T790M,V948R None None XRAY 2.2 0.191 0.223 B 331 296 13 0 0 13 [[712, 970]] 1.0 6duk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6DUKC 699 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.661 14.391 BLBplus -137.36, 170.05 61.14, 32.95 -87.42, 165.36 52.89, 84.68 86.51, 15.0 out-out out 13.749 Saltbr-out 12.387 HRD-in -66.04, -61.2 80.35, -9.27 out-out-none SNCoon out-none ActLoopNT-out 8.286 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.92 APE8-dihe-in -77.64, 67.39 APE8-rot-na 32.93 APE67-dihe-in -71.69, -8.16 -55.72, -42.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.823 T790M,V948R None None XRAY 2.2 0.191 0.223 C 331 295 14 0 0 14 [[712, 970]] 1.0 6duk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6DUKD 701 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.605 14.634 BLBplus -137.83, 165.45 65.63, 29.61 -82.3, 167.28 56.12, 84.13 94.16, 13.47 out-out out 14.053 Saltbr-out 14.886 HRD-in -74.03, -57.71 81.46, -18.53 out-out-out SNCooo out-out ActLoopNT-out 7.321 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -76.03, 11.31 APE9-dihe-in -134.89, 121.24 APE8-dihe-in -86.59, 77.19 APE8-rot-na 34.21 APE67-dihe-in -72.84, -7.51 -59.65, -43.13 APE12-dist-na 17.747 APE11-dist-na 15.555 APE10-dist-na 11.903 APE9-dist-in 7.539 T790M,V948R None None XRAY 2.2 0.191 0.223 D 331 307 0 0 0 0 [[712, 970]] 1.0 6duk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6DUKE 698 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.706 14.387 BLBplus -132.31, 167.27 63.11, 42.82 -102.17, 159.55 52.62, 85.09 88.84, 16.78 out-out out 13.768 Saltbr-out 14.361 HRD-in -70.33, -59.21 85.76, -23.74 out-out-none SNCoon out-none ActLoopNT-out 7.686 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 1.83 APE9-dihe-in -127.74, 112.92 APE8-dihe-in -68.38, 64.27 APE8-rot-na 21.48 APE67-dihe-in -73.72, -8.33 -52.7, -41.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.291 APE9-dist-in 7.941 T790M,V948R None None XRAY 2.2 0.191 0.223 E 331 298 12 0 0 12 [[712, 970]] 1.0 6duk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6DUKF 701 1009 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.653 14.612 BLBplus -133.82, 164.75 63.96, 32.85 -83.32, 163.7 53.83, 93.49 88.31, 19.42 out-out out 14.108 Saltbr-out 15.144 HRD-in -67.38, -62.37 88.35, -19.9 out-out-none SNCoon out-none ActLoopNT-out 7.319 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.72 APE8-dihe-in -80.72, 70.63 APE8-rot-na 32.98 APE67-dihe-in -75.6, -2.87 -62.49, -36.24 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.841 T790M,V948R None None XRAY 2.2 0.191 0.223 F 331 298 11 0 0 11 [[712, 970]] 1.0 6duk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXKD 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.861 14.45 BLBplus -134.29, 170.65 60.11, 37.92 -95.07, 160.21 48.8, 86.41 74.63, 26.88 out-out out 13.457 Saltbr-out 11.763 HRD-in -66.46, -59.56 80.54, -6.1 out-out-none SNCoon out-none ActLoopNT-out 8.903 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.41 APE8-dihe-in -81.29, 71.57 APE8-rot-na 30.4 APE67-dihe-in -73.66, -4.05 -53.54, -44.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.472 T790M,V948R None None XRAY 3.1 0.223 0.261 D 331 294 14 0 0 14 [[712, 970]] 1.0 7jxk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXMD 700 1007 1210.0 ANP:1101,9LL:1103 ATPlike,Type3 Inactive DFGin 4.952 14.337 BLBplus -135.28, 170.25 61.86, 31.57 -85.27, 155.14 53.77, 85.22 78.23, 19.31 out-out out 13.049 Saltbr-out 11.894 HRD-in -66.52, -63.02 84.71, -6.37 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.04 APE8-dihe-in -80.42, 66.88 APE8-rot-na 32.97 APE67-dihe-in -76.05, -3.45 -51.47, -42.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.762 T790M,V948R None None XRAY 2.192 0.228 0.271 D 331 291 17 0 0 17 [[712, 970]] 1.0 7jxm TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXPA 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.747 14.617 BLBplus -136.18, 166.76 64.66, 34.04 -92.53, 168.9 56.02, 85.41 85.63, 11.86 out-out out 13.988 Saltbr-out 14.307 HRD-in -74.54, -64.28 89.28, -17.63 out-out-out SNCooo out-out ActLoopNT-out 7.509 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.63, -15.8 APE9-dihe-in -113.05, 126.54 APE8-dihe-in -83.29, 68.9 APE8-rot-na 33.94 APE67-dihe-in -74.36, -3.96 -52.3, -47.62 APE12-dist-na 17.096 APE11-dist-na 14.956 APE10-dist-na 11.693 APE9-dist-in 7.406 T790M,V948R None None XRAY 2.16 0.214 0.247 A 331 308 0 0 0 0 [[712, 970]] 1.0 7jxp TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXPB 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.671 14.511 BLBplus -135.21, 165.17 64.35, 37.85 -90.15, 169.17 53.82, 91.67 84.59, 7.68 out-out out 13.756 Saltbr-out 13.888 HRD-in -70.65, -63.17 87.36, -17.28 out-out-out SNCooo out-out ActLoopNT-out 7.592 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.44, -17.16 APE9-dihe-in -126.66, 129.43 APE8-dihe-in -78.52, 67.74 APE8-rot-na 34.72 APE67-dihe-in -76.32, -3.64 -51.52, -45.13 APE12-dist-na 17.438 APE11-dist-na 15.214 APE10-dist-na 12.275 APE9-dist-in 7.617 T790M,V948R None None XRAY 2.16 0.214 0.247 B 331 308 0 0 0 0 [[712, 970]] 1.0 7jxp TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXPD 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.766 14.661 BLBplus -135.69, 167.35 65.6, 33.96 -89.97, 168.72 55.6, 87.2 84.96, 9.82 out-out out 13.526 Saltbr-out 11.283 HRD-in -71.06, -65.03 87.13, -14.24 out-out-none SNCoon out-none ActLoopNT-out 8.004 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.01 APE8-dihe-in -77.89, 69.26 APE8-rot-na 33.29 APE67-dihe-in -74.9, -2.69 -52.27, -42.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.744 T790M,V948R None None XRAY 2.16 0.214 0.247 D 331 294 14 0 0 14 [[712, 970]] 1.0 7jxp TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXPF 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.974 14.702 BLBplus -136.82, 166.82 61.14, 36.57 -93.57, 171.83 53.4, 92.66 83.03, -0.51 out-out out 13.674 Saltbr-out 11.57 HRD-in -71.01, -63.71 87.17, -13.68 out-out-none SNCoon out-none ActLoopNT-out 9.118 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.33 APE8-dihe-in -78.62, 69.48 APE8-rot-na 32.72 APE67-dihe-in -72.69, -4.28 -52.16, -45.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.621 T790M,V948R None None XRAY 2.16 0.214 0.247 F 331 294 14 0 0 14 [[712, 970]] 1.0 7jxp TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXQB 701 1007 1210.0 ANP:1102,VNS:1103 ATPlike,Type3 Inactive DFGin 4.915 14.438 BLBplus -136.8, 171.78 58.87, 35.86 -91.33, 162.29 51.51, 87.21 80.67, 16.0 out-out out 13.335 Saltbr-out 12.698 HRD-in -67.21, -58.71 77.88, -12.51 out-out-none SNCoon out-none ActLoopNT-out 8.896 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -177.71 APE9-dihe-in -105.47, 135.84 APE8-dihe-in -83.2, 67.78 APE8-rot-na 33.37 APE67-dihe-in -74.22, -7.65 -49.73, -41.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.734 APE9-dist-in 7.645 T790M,V948R None None XRAY 1.83 0.185 0.218 B 331 297 10 0 0 10 [[712, 970]] 1.0 7jxq TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXQD 700 1007 1210.0 ANP:1102,VNS:1103 ATPlike,Type3 Inactive DFGin 4.844 14.328 BLBplus -136.14, 172.56 58.98, 36.18 -92.84, 162.13 51.55, 88.05 79.36, 17.26 out-out out 13.42 Saltbr-out 11.89 HRD-in -65.12, -58.0 78.92, -12.53 out-out-none SNCoon out-none ActLoopNT-out 8.94 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.09 APE8-dihe-in -80.19, 68.24 APE8-rot-na 33.29 APE67-dihe-in -74.77, -5.19 -50.69, -44.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.579 T790M,V948R None None XRAY 1.83 0.185 0.218 D 331 298 10 0 0 10 [[712, 970]] 1.0 7jxq TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7LTXA 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.248 14.564 BLBplus -135.35, 163.04 64.03, 33.94 -82.37, 179.4 48.16, 87.26 -162.42, -162.89 out-out out 13.182 Saltbr-out 10.599 HRD-in -67.02, -61.48 82.46, -5.8 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.93 APE8-dihe-in -80.94, 68.72 APE8-rot-na 31.43 APE67-dihe-in -70.18, -9.53 -51.9, -44.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.02 T790M,V948R None None XRAY 2.3 0.187 0.216 A 331 292 16 0 0 16 [[712, 970]] 1.0 7ltx TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7LTXB 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.197 14.495 BLBplus -136.17, 169.66 62.42, 34.77 -78.22, 170.05 42.44, 90.17 -152.16, -165.64 out-out out 13.123 Saltbr-out 10.226 HRD-in -65.63, -61.11 82.51, -6.05 out-out-none SNCoon out-none ActLoopNT-out 9.239 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.13 APE8-dihe-in -82.01, 66.41 APE8-rot-na 31.46 APE67-dihe-in -73.58, -7.26 -49.71, -42.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.829 T790M,V948R None None XRAY 2.3 0.187 0.216 B 331 293 15 0 0 15 [[712, 970]] 1.0 7ltx TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7LTXC 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.123 14.511 BLBplus -136.55, 165.71 63.6, 32.17 -87.45, 156.27 46.73, 94.27 148.1, 156.05 out-out out 13.071 Saltbr-out 10.076 HRD-in -65.09, -59.89 81.29, -6.26 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.8 APE8-dihe-in -79.63, 67.92 APE8-rot-na 31.3 APE67-dihe-in -72.94, -5.81 -52.93, -44.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.864 T790M,V948R None None XRAY 2.3 0.187 0.216 C 331 292 16 0 0 16 [[712, 970]] 1.0 7ltx TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7LTXD 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.346 14.443 BLBplus -137.08, 165.99 63.56, 34.05 -81.77, 167.16 44.82, 94.68 -177.57, 165.83 out-out out 12.986 Saltbr-out 10.34 HRD-in -68.33, -62.57 83.39, -4.99 out-out-none SNCoon out-none ActLoopNT-out 9.494 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.9 APE8-dihe-in -80.86, 67.56 APE8-rot-na 30.12 APE67-dihe-in -73.23, -5.97 -50.49, -42.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.917 T790M,V948R None None XRAY 2.3 0.187 0.216 D 331 293 15 0 0 15 [[712, 970]] 1.0 7ltx TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8GB4A 700 1007 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.738 14.778 BLBplus -140.96, 174.92 57.37, 44.23 -99.53, 158.98 50.67, 86.24 74.62, 16.37 out-out out 13.355 Saltbr-out 11.698 HRD-in -69.91, -59.18 79.33, -9.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.01 APE8-dihe-in -76.27, 67.14 APE8-rot-na 30.24 APE67-dihe-in -75.65, -5.48 -58.37, -41.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.058 T790M,V948R None None XRAY 2.59 0.23 0.254 A 331 292 16 0 0 16 [[712, 970]] 1.0 8gb4 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8GB4B 700 1007 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.858 14.681 BLBplus -140.61, 174.15 57.09, 43.59 -100.33, 162.57 51.99, 86.76 77.41, 18.84 out-out out 13.39 Saltbr-out 10.531 HRD-in -69.24, -58.17 79.24, -10.08 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.16 APE8-rot-na 30.06 APE67-dihe-in -75.09, -5.85 -58.81, -39.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 2.59 0.23 0.254 B 331 290 18 0 0 18 [[712, 970]] 1.0 8gb4 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8GB4C 700 1012 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.732 14.602 BLBplus -141.16, 174.43 57.44, 44.8 -99.46, 158.79 49.11, 85.48 74.36, 22.53 out-out out 13.185 Saltbr-out 11.537 HRD-in -70.07, -59.0 77.64, -8.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.65 APE8-dihe-in -76.99, 66.94 APE8-rot-na 30.24 APE67-dihe-in -75.42, -5.6 -59.05, -41.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.014 T790M,V948R None None XRAY 2.59 0.23 0.254 C 331 297 16 0 0 16 [[712, 970]] 1.0 8gb4 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8GB4D 700 1007 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.686 14.698 BLBplus -141.21, 175.0 57.29, 43.49 -99.79, 159.92 51.61, 87.18 76.57, 22.15 out-out out 13.561 Saltbr-out 10.91 HRD-in -69.19, -58.43 79.07, -10.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 65.97 APE8-rot-na 30.21 APE67-dihe-in -74.96, -5.48 -59.31, -40.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 2.59 0.23 0.254 D 331 291 17 0 0 17 [[712, 970]] 1.0 8gb4 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7K1IA 700 1007 1210.0 ANP:1102,VNS:1103 ATPlike,Type3 Inactive DFGin 4.837 14.412 BLBplus -124.92, 173.52 55.34, 38.4 -93.27, 168.4 51.69, 86.03 70.99, 11.24 out-out out 13.596 Saltbr-out 12.212 HRD-in -68.02, -55.76 76.66, -7.58 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.86 APE8-dihe-in -84.0, 73.03 APE8-rot-na 29.2 APE67-dihe-in -72.27, -9.54 -58.41, -42.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.42 L858R,V948R None None XRAY 3.202 0.266 0.311 A 331 288 20 0 0 17 [[712, 970]] 1.0 7k1i TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6WXNA 699 1014 1210.0 No_ligand No_ligand Inactive DFGin 4.853 14.024 BLBplus -126.21, 168.87 69.17, 33.07 -82.8, 162.03 48.79, 88.7 44.39, 44.22 out-out out 13.115 Saltbr-out 12.745 HRD-in -70.78, -60.03 85.71, -15.47 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.13 APE8-dihe-in -86.46, 71.73 APE8-rot-na 36.97 APE67-dihe-in -76.26, -5.03 -50.8, -39.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.133 T790M,V948R None None XRAY 1.76 0.209 0.235 A 328 298 16 0 0 16 [[712, 970]] 1.0 6wxn TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7UKWA 702 1014 1210.0 No_ligand No_ligand Inactive DFGin 3.581 13.829 BLBplus -128.6, 172.3 69.85, 12.86 -66.14, 147.6 72.2, 96.6 82.34, -29.23 out-out out 13.797 Saltbr-out 13.846 HRD-in -71.25, -59.42 83.42, -8.1 out-out-out SNCooo out-out ActLoopNT-out 6.712 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -76.18, -16.76 APE9-dihe-in -80.09, 122.05 APE8-dihe-in -79.83, 67.74 APE8-rot-na 31.37 APE67-dihe-in -79.14, 0.49 -56.49, -38.64 APE12-dist-na 18.86 APE11-dist-na 16.017 APE10-dist-na 11.421 APE9-dist-in 7.829 T790M,V948R None None XRAY 2.6 0.198 0.25 A 328 306 2 0 0 2 [[712, 970]] 1.0 7ukw TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7TVDA 698 1009 1210.0 No_ligand No_ligand Inactive DFGin 4.431 14.232 BLBplus -146.5, 168.0 61.48, 51.23 -104.55, 142.32 34.5, 86.81 71.61, 13.83 in-out in 7.927 Saltbr-out 4.135 HRD-in -70.54, -56.96 76.98, -3.53 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.89 APE8-dihe-in -84.43, 67.37 APE8-rot-na 26.32 APE67-dihe-in -72.01, -9.76 -63.46, -35.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.453 None None None XRAY 2.96 0.242 0.277 A 335 292 16 0 0 16 [[712, 970]] 1.0 7tvd TYR_EGFR_HUMAN TYR 2.7e-84 288.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5ZTOA 697 1017 1210.0 9JO:1101 Type1 Inactive DFGin 4.655 14.859 BLBplus -130.18, 175.35 63.93, 30.88 -101.94, 137.29 49.3, 91.62 80.58, 29.83 in-in in 8.509 Saltbr-in 2.925 HRD-in -69.78, -52.43 69.58, -8.35 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 37.71 APE8-rot-na 39.97 APE67-dihe-in -56.49, -26.37 -64.04, -33.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,C797S None None XRAY 2.649 0.234 0.272 A 331 294 19 0 0 17 [[712, 970]] 1.0 5zto TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V66D 701 1014 1210.0 QP1:1203 Type1 Inactive DFGin 4.096 13.943 BLBplus -133.25, 173.78 71.02, 17.1 -71.48, 143.37 58.07, 94.52 76.41, -7.86 out-out out 14.093 Saltbr-out 14.181 HRD-in -71.49, -55.9 81.36, -15.85 out-out-out SNCooo out-out ActLoopNT-out 6.527 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -93.31, -7.02 APE9-dihe-in -100.17, 123.42 APE8-dihe-in -79.15, 63.8 APE8-rot-na 32.12 APE67-dihe-in -77.89, -1.58 -50.41, -43.42 APE12-dist-na 18.544 APE11-dist-na 16.043 APE10-dist-na 11.737 APE9-dist-in 7.947 T790M,V948R None None XRAY 1.79 0.187 0.226 D 327 314 0 0 0 0 [[712, 970]] 1.0 6v66 TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V6KA 700 1014 1210.0 QQJ:1202 Type1 Inactive DFGin 3.867 13.844 BLBplus -126.62, 172.08 72.11, 17.73 -68.46, 144.29 67.31, 94.55 80.98, -14.27 out-out out 14.069 Saltbr-out 13.117 HRD-in -76.25, -55.46 78.72, -10.68 out-out-none SNCoon out-none ActLoopNT-out 6.607 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.92 APE8-dihe-in -90.83, 73.86 APE8-rot-na 33.95 APE67-dihe-in -71.2, -5.54 -52.83, -43.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.981 T790M,V948R None None XRAY 2.2 0.215 0.239 A 327 300 13 0 0 13 [[712, 970]] 1.0 6v6k TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V6KC 700 1014 1210.0 QQJ:1202 Type1 Inactive DFGin 3.742 14.114 BLBplus -126.65, 174.74 68.29, 24.91 -77.8, 144.03 65.82, 93.11 70.95, 0.99 out-out out 14.113 Saltbr-out 13.32 HRD-in -74.46, -61.55 88.29, -10.53 out-out-none SNCoon out-none ActLoopNT-out 6.895 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.13 APE8-dihe-in -80.16, 64.39 APE8-rot-na 34.44 APE67-dihe-in -74.67, -2.44 -48.42, -47.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.908 T790M,V948R None None XRAY 2.2 0.215 0.239 C 327 302 13 0 0 13 [[712, 970]] 1.0 6v6k TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V6KD 701 1014 1210.0 QQJ:1202 Type1 Inactive DFGin 3.349 14.94 BLBplus -117.8, 170.46 73.04, 20.38 -74.63, 149.6 91.38, 90.72 79.09, -12.98 out-out out 13.99 Saltbr-out 13.446 HRD-in -72.66, -55.83 84.51, -14.82 out-out-out SNCooo out-out ActLoopNT-out 6.713 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.51, 1.42 APE9-dihe-in -116.89, 115.01 APE8-dihe-in -75.54, 67.0 APE8-rot-na 30.88 APE67-dihe-in -77.85, 1.7 -51.8, -42.48 APE12-dist-na 17.569 APE11-dist-na 15.006 APE10-dist-na 10.889 APE9-dist-in 7.789 T790M,V948R None None XRAY 2.2 0.215 0.239 D 327 314 0 0 0 0 [[712, 970]] 1.0 6v6k TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V6KF 701 1014 1210.0 QQJ:1202 Type1 Inactive DFGin 3.98 13.825 BLBplus -120.93, 173.29 72.83, 17.47 -73.23, 142.03 63.46, 93.26 87.26, -10.56 out-out out 13.994 Saltbr-out 13.923 HRD-in -64.5, -59.24 85.68, -12.32 out-out-out SNCooo out-out ActLoopNT-out 6.808 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -89.94, 8.75 APE9-dihe-in -116.9, 120.13 APE8-dihe-in -80.85, 65.83 APE8-rot-na 33.37 APE67-dihe-in -73.94, -2.38 -51.14, -44.1 APE12-dist-na 18.149 APE11-dist-na 15.602 APE10-dist-na 11.467 APE9-dist-out 8.143 T790M,V948R None None XRAY 2.2 0.215 0.239 F 327 306 8 0 0 8 [[712, 970]] 1.0 6v6k TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V6KG 701 1014 1210.0 QQJ:1202 Type1 Inactive DFGin 3.875 13.95 BLBplus -130.73, 172.58 73.14, 20.78 -75.62, 138.08 60.03, 93.12 84.61, -15.28 out-out out 14.036 Saltbr-out 14.615 HRD-in -71.13, -52.8 79.1, -13.85 out-out-out SNCooo out-out ActLoopNT-out 6.47 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.69, -0.28 APE9-dihe-in -105.61, 125.6 APE8-dihe-in -80.99, 60.63 APE8-rot-na 33.61 APE67-dihe-in -75.24, -7.52 -47.39, -44.79 APE12-dist-na 18.186 APE11-dist-na 15.859 APE10-dist-na 11.416 APE9-dist-in 7.933 T790M,V948R None None XRAY 2.2 0.215 0.239 G 327 314 0 0 0 0 [[712, 970]] 1.0 6v6k TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V6OC 701 1011 1210.0 QQM:1202 Type1 Inactive DFGin 3.644 14.214 BLBplus -122.87, 171.43 70.23, 18.79 -66.69, 140.71 67.25, 92.35 81.97, -11.3 out-out out 14.261 Saltbr-out 13.537 HRD-in -75.21, -54.45 82.69, -13.83 out-out-out SNCooo out-out ActLoopNT-out 6.78 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.15 APE8-dihe-in -81.1, 67.37 APE8-rot-na 31.91 APE67-dihe-in -73.98, -4.02 -53.95, -44.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.276 T790M,V948R None None XRAY 2.1 0.196 0.221 C 327 297 12 0 0 12 [[712, 970]] 1.0 6v6o TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V6OD 701 1014 1210.0 QQM:1202 Type1 Inactive DFGin 3.863 14.109 BLBplus -124.4, 171.55 69.25, 17.62 -67.5, 139.98 64.11, 93.51 81.27, -10.57 out-out out 14.298 Saltbr-out 13.561 HRD-in -74.72, -54.65 82.6, -12.74 out-out-out SNCooo out-out ActLoopNT-out 6.694 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.63, -11.25 APE9-dihe-in -98.47, 121.43 APE8-dihe-in -79.76, 67.8 APE8-rot-na 32.25 APE67-dihe-in -74.09, -4.64 -53.64, -43.16 APE12-dist-na 18.514 APE11-dist-na 15.909 APE10-dist-na 11.537 APE9-dist-in 7.999 T790M,V948R None None XRAY 2.1 0.196 0.221 D 327 314 0 0 0 0 [[712, 970]] 1.0 6v6o TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V6OE 701 1014 1210.0 QQM:1202 Type1 Inactive DFGin 3.762 14.126 BLBplus -123.9, 171.7 69.62, 18.55 -66.64, 139.7 64.92, 95.49 81.38, -10.3 out-out out 14.01 Saltbr-out 14.506 HRD-in -75.07, -55.34 81.99, -12.92 out-out-none SNCoon out-none ActLoopNT-out 6.897 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -28.58 APE9-dihe-in -100.13, 119.03 APE8-dihe-in -80.06, 70.49 APE8-rot-na 32.0 APE67-dihe-in -73.71, -4.57 -52.25, -42.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.853 APE9-dist-in 7.834 T790M,V948R None None XRAY 2.1 0.196 0.221 E 327 303 11 0 0 11 [[712, 970]] 1.0 6v6o TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V6OH 700 1014 1210.0 QQM:1202 Type1 Inactive DFGin 3.651 13.984 BLBplus -123.38, 171.8 70.53, 19.82 -66.37, 140.7 65.92, 91.26 79.41, -10.87 out-out out 13.699 Saltbr-out 12.865 HRD-in -75.67, -55.2 81.77, -12.73 out-out-none SNCoon out-none ActLoopNT-out 6.85 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -16.84 APE9-dihe-in -111.7, 114.25 APE8-dihe-in -84.18, 71.19 APE8-rot-na 31.92 APE67-dihe-in -73.23, -5.03 -51.26, -41.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.228 APE9-dist-in 7.798 T790M,V948R None None XRAY 2.1 0.196 0.221 H 327 299 11 0 0 11 [[712, 970]] 1.0 6v6o TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V5NA 701 1014 1210.0 QP7:1101 Type1 Inactive DFGin 3.874 14.043 BLBplus -131.86, 170.73 72.76, 5.92 -62.08, 148.09 69.53, 94.27 88.44, -36.3 out-out out 13.696 Saltbr-out 14.382 HRD-in -69.73, -62.04 88.23, -15.47 out-out-out SNCooo out-out ActLoopNT-out 6.764 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 81.73, -91.94 APE9-dihe-in -62.41, 118.62 APE8-dihe-in -74.09, 69.5 APE8-rot-na 30.39 APE67-dihe-in -79.22, -7.19 -56.4, -40.52 APE12-dist-na 19.113 APE11-dist-na 16.022 APE10-dist-na 12.476 APE9-dist-in 7.932 T790M,V948R None None XRAY 2.4 0.194 0.243 A 328 314 0 0 0 0 [[712, 970]] 1.0 6v5n TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V5PA 701 1014 1210.0 QP4:1101 Type1 Inactive DFGin 4.083 13.904 BLBplus -131.2, 176.01 67.46, 19.27 -70.58, 141.95 55.96, 94.52 75.39, -7.99 out-out out 14.12 Saltbr-out 13.869 HRD-in -75.98, -55.78 84.58, -17.4 out-out-out SNCooo out-out ActLoopNT-out 6.727 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -68.57, -1.97 APE9-dihe-in -106.2, 124.29 APE8-dihe-in -83.08, 63.06 APE8-rot-na 33.31 APE67-dihe-in -79.73, -4.58 -50.4, -37.06 APE12-dist-na 17.954 APE11-dist-na 15.473 APE10-dist-na 10.923 APE9-dist-in 7.812 T790M,V948R None None XRAY 2.3 0.18 0.194 A 328 314 0 0 0 0 [[712, 970]] 1.0 6v5p TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXLB 700 1005 1210.0 VO7:1101 Type1 Inactive DFGin 5.246 13.632 BLBplus -132.57, 173.49 63.97, 37.87 -98.02, 155.82 53.78, 87.52 97.69, 168.21 out-out out 13.274 Saltbr-out 10.365 HRD-in -68.45, -55.65 82.41, -9.47 out-out-none SNCoon out-none ActLoopNT-out 11.071 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.84 APE8-dihe-in -79.09, 72.8 APE8-rot-na 32.94 APE67-dihe-in -75.09, -2.58 -53.56, -42.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.945 T790M,V948R None None XRAY 2.4 0.21 0.239 B 331 285 15 0 0 15 [[712, 970]] 1.0 7jxl TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXLC 700 1007 1210.0 VO7:1101 Type1 Inactive DFGin 5.046 14.21 BLBplus -131.44, 169.42 60.64, 42.48 -100.4, 172.86 57.82, 96.69 101.73, -98.55 out-out out 13.295 Saltbr-out 10.82 HRD-in -68.59, -57.74 83.98, -10.65 out-out-out SNCooo out-out ActLoopNT-out 8.773 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.84 APE8-dihe-in -84.48, 72.12 APE8-rot-na 33.75 APE67-dihe-in -77.24, -3.14 -52.76, -40.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.068 T790M,V948R None None XRAY 2.4 0.21 0.239 C 331 292 16 0 0 14 [[712, 970]] 1.0 7jxl TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXLD 700 1007 1210.0 VO7:1101 Type1 Inactive DFGin 5.173 13.928 BLBplus -133.7, 169.87 61.73, 43.83 -103.39, 170.74 58.35, 94.82 87.82, 34.82 out-out out 13.626 Saltbr-out 11.064 HRD-in -67.75, -57.45 83.8, -10.92 out-out-none SNCoon out-none ActLoopNT-out 9.169 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 68.84 APE8-rot-na 32.75 APE67-dihe-in -76.98, -2.85 -51.41, -42.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 2.4 0.21 0.239 D 331 292 16 0 0 16 [[712, 970]] 1.0 7jxl TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7KY0A 701 1007 1210.0 XA4:1101 Type1 Inactive DFGin 4.934 13.72 BLBplus -141.11, -177.29 64.89, 51.57 -115.71, 120.75 54.84, 96.01 152.25, 35.37 out-out out 13.485 Saltbr-out 12.212 HRD-in -66.11, -56.54 81.78, -10.06 out-out-none SNCoon out-none ActLoopNT-out 8.644 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.15 APE8-dihe-in -82.92, 73.8 APE8-rot-na 32.47 APE67-dihe-in -76.16, -2.99 -59.22, -41.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.733 T790M,V948R None None XRAY 3.1 0.24 0.292 A 331 288 14 0 0 14 [[712, 970]] 1.0 7ky0 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6TFYA 699 982 1210.0 N7Z:1101 Type1 Inactive DFGin 4.097 14.31 BLBplus -125.48, -177.34 63.89, 37.21 -107.03, 143.92 80.58, 98.31 105.92, 8.7 out-out out 14.098 Saltbr-out 12.905 HRD-in -73.28, -55.39 77.03, -6.83 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 105.38 APE9-dihe-in -67.96, 130.83 APE8-dihe-in -78.11, 63.29 APE8-rot-na 31.69 APE67-dihe-in -71.25, -7.27 -55.57, -39.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.72 APE9-dist-out 8.124 T790M,V948R None None XRAY 1.7 0.193 0.212 A 333 266 18 0 0 15 [[712, 970]] 1.0 6tfy TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7A6JB 699 984 1210.0 R2E:1101 Type1 Inactive DFGin 5.458 13.796 BLBplus -144.25, -179.46 65.49, 29.82 -99.51, 152.89 65.46, 98.76 73.1, -125.3 out-out out 13.459 Saltbr-out 10.998 HRD-in -71.08, -55.82 83.36, -14.67 out-out-out SNCooo out-out ActLoopNT-out 9.376 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -57.31 APE8-dihe-in -78.95, 60.24 APE8-rot-na 32.73 APE67-dihe-in -71.17, -11.35 -55.28, -40.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.728 T790M,V948R None None XRAY 2.0 0.192 0.216 B 333 271 15 0 0 15 [[712, 970]] 1.0 7a6j TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7ZYQA 700 984 1210.0 V58:1101 Type1 Inactive DFGin 5.351 14.039 BLBplus -126.85, 173.6 59.25, 54.42 -119.93, 159.99 65.54, 96.87 75.52, -19.59 out-none out 14.29 Saltbr-none 999.0 HRD-in -75.55, -54.64 81.44, -14.09 none-out-out SNCnoo out-out ActLoopNT-out 7.214 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 113.44 APE8-dihe-in -82.18, 68.98 APE8-rot-na 30.56 APE67-dihe-in -72.77, -5.68 -55.78, -43.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.137 T790M,V948R None None XRAY 2.1 0.199 0.223 A 333 270 15 0 0 15 [[712, 970]] 1.0 7zyq TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5FEEA 697 1018 1210.0 5X4:1101 Type1 Inactive DFGin 4.52 13.749 BLBplus -148.22, -167.33 40.92, 69.1 -115.76, 70.34 31.37, 65.2 -71.51, -22.89 in-in in 8.791 Saltbr-in 3.318 HRD-in -72.57, -51.63 72.54, -3.53 in-in-out SNCiio in-out ActLoopNT-in 3.044 ActLoopCT-out TYR APEdihe_iioao APEdist_aaai APE10-dihe-in -61.11, 145.12 APE9-dihe-in -133.91, 152.17 APE8-dihe-out -65.95, -32.07 APE8-rot-na 335.9 APE67-dihe-out -78.14, -18.7 66.26, -53.45 APE12-dist-na 11.21 APE11-dist-na 8.385 APE10-dist-na 10.2 APE9-dist-in 6.967 T790M None None XRAY 2.7 0.192 0.229 A 328 287 14 0 0 5 [[712, 970]] 1.0 5fee TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5GTYA 700 1014 1210.0 816:1101 Type1 Inactive DFGin 3.919 14.254 BLBplus -136.6, 160.21 83.79, 10.32 -71.62, 130.12 75.47, 69.3 84.21, -2.08 out-out out 14.11 Saltbr-out 15.158 HRD-in -64.26, -47.89 82.5, -11.45 out-out-none SNCoon out-none ActLoopNT-out 7.176 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 130.2 APE9-dihe-in -65.39, 157.4 APE8-dihe-in -83.63, 78.13 APE8-rot-na 34.93 APE67-dihe-in -61.71, -42.12 -62.97, -39.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 15.408 APE9-dist-in 7.816 T790M None None XRAY 3.14 0.258 0.28 A 331 300 15 0 0 11 [[712, 970]] 1.0 5gty TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5GTYC 700 1013 1210.0 816:1101 Type1 Inactive DFGin 4.284 15.817 BLBplus -149.79, 169.46 71.39, 12.4 -62.83, 164.89 105.62, 48.04 58.84, -127.22 out-out out 13.78 Saltbr-out 14.402 HRD-in -63.98, -44.78 76.23, -10.44 out-out-none SNCoon out-none ActLoopNT-out 8.843 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -4.61 APE8-rot-na 27.64 APE67-dihe-in -61.37, -42.92 -62.91, -38.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M None None XRAY 3.14 0.258 0.28 C 331 295 19 0 0 15 [[712, 970]] 1.0 5gty TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5GTYF 700 1013 1210.0 816:1101 Type1 Inactive DFGin 4.566 15.591 BLBplus -143.69, 172.87 60.29, 35.9 -98.19, 125.74 96.55, 67.96 83.35, -2.23 out-none out 14.169 Saltbr-none 999.0 HRD-out -91.66, 107.92 -65.69, -38.43 none-out-out SNCnoo out-out ActLoopNT-out 6.102 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -163.83 APE8-dihe-in -84.57, 72.91 APE8-rot-na 22.97 APE67-dihe-in -62.3, -42.82 -63.85, -40.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.491 T790M None None XRAY 3.14 0.258 0.28 F 331 297 17 0 0 13 [[712, 970]] 1.0 5gty TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6XL4A 700 1007 1210.0 Q6K:1301,NQ1:1302 Type1,Type3 Inactive DFGin 5.098 14.695 BLBplus -134.42, 176.69 66.92, 16.35 -78.69, 146.78 51.46, 92.89 75.99, 3.76 out-out out 13.363 Saltbr-out 12.539 HRD-in -71.16, -58.13 77.59, -5.31 out-out-none SNCoon out-none ActLoopNT-out 7.386 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.31 APE8-dihe-in -78.15, 72.0 APE8-rot-na 31.9 APE67-dihe-in -74.09, -1.62 -55.44, -42.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.703 T790M,V948R None None XRAY 2.06 0.216 0.252 A 328 293 15 0 0 15 [[712, 970]] 1.0 6xl4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXKA 700 1007 1210.0 8BS:1101,JBJ:1102 Type1,Type3 Inactive DFGin 4.862 14.824 BLBplus -134.12, 169.24 58.43, 39.5 -93.7, 161.51 49.25, 87.25 75.0, 16.23 out-out out 13.778 Saltbr-out 10.461 HRD-in -66.55, -57.53 81.35, -6.11 out-out-none SNCoon out-none ActLoopNT-out 8.816 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.68 APE8-dihe-in -81.09, 70.58 APE8-rot-na 30.58 APE67-dihe-in -73.21, -4.24 -54.1, -46.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.489 T790M,V948R None None XRAY 3.1 0.223 0.261 A 331 293 15 0 0 15 [[712, 970]] 1.0 7jxk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXKC 701 1007 1210.0 8BS:1101,JBJ:1102 Type1,Type3 Inactive DFGin 4.503 14.594 BLBplus -134.13, 170.52 59.34, 39.88 -92.58, 159.61 51.08, 87.14 75.55, 20.71 out-out out 13.608 Saltbr-out 11.925 HRD-in -66.31, -58.5 79.98, -6.68 out-out-none SNCoon out-none ActLoopNT-out 8.44 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.55 APE8-dihe-in -81.28, 70.99 APE8-rot-na 30.58 APE67-dihe-in -73.05, -5.14 -53.98, -44.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.444 T790M,V948R None None XRAY 3.1 0.223 0.261 C 331 292 15 0 0 15 [[712, 970]] 1.0 7jxk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXKE 700 1007 1210.0 8BS:1101,JBJ:1102 Type1,Type3 Inactive DFGin 4.893 14.488 BLBplus -134.7, 170.02 59.73, 38.84 -95.72, 161.23 49.85, 87.39 75.41, 21.47 out-out out 13.509 Saltbr-out 11.783 HRD-in -66.69, -59.11 80.54, -6.15 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.43 APE8-dihe-in -79.83, 71.88 APE8-rot-na 29.74 APE67-dihe-in -73.96, -4.52 -53.36, -45.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.534 T790M,V948R None None XRAY 3.1 0.223 0.261 E 331 287 16 0 0 16 [[712, 970]] 1.0 7jxk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXKF 700 1007 1210.0 8BS:1101,JBJ:1102 Type1,Type3 Inactive DFGin 4.872 14.387 BLBplus -134.77, 169.91 59.08, 39.36 -94.94, 160.87 49.89, 87.34 75.14, 17.06 out-out out 13.528 Saltbr-out 12.787 HRD-in -66.88, -58.5 80.33, -5.79 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.79 APE8-dihe-in -81.39, 71.1 APE8-rot-na 29.52 APE67-dihe-in -73.84, -5.2 -54.64, -45.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.478 T790M,V948R None None XRAY 3.1 0.223 0.261 F 331 292 16 0 0 16 [[712, 970]] 1.0 7jxk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXMB 701 1012 1210.0 YY3:1101,9LL:1102 Type1,Type3 Inactive DFGin 5.155 14.648 BLBplus -133.95, 169.04 59.67, 39.65 -96.16, 166.65 49.37, 86.58 68.24, 16.57 out-out out 13.166 Saltbr-out 10.454 HRD-in -67.1, -62.37 83.6, -7.78 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.13 APE8-dihe-in -90.39, 74.47 APE8-rot-na 39.92 APE67-dihe-in -71.29, -11.25 -51.45, -39.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.779 T790M,V948R None None XRAY 2.192 0.228 0.271 B 331 296 16 0 0 16 [[712, 970]] 1.0 7jxm TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXWA 700 1007 1210.0 YY3:1301,VNS:1302 Type1,Type3 Inactive DFGin 4.579 14.666 BLBplus -138.64, 168.46 50.29, 44.7 -88.71, 170.77 52.75, 84.47 69.65, 17.94 out-out out 13.177 Saltbr-out 9.933 HRD-in -64.27, -62.7 83.56, -10.71 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -29.5 APE8-dihe-in -90.52, 58.97 APE8-rot-na 25.71 APE67-dihe-in -73.18, -5.87 -63.78, -37.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.655 T790M,V948R None None XRAY 2.5 0.276 0.319 A 331 288 20 0 0 16 [[712, 970]] 1.0 7jxw TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXWB 700 1007 1210.0 YY3:1301,VNS:1302 Type1,Type3 Inactive DFGin 4.889 14.548 BLBplus -137.39, 167.04 52.05, 48.78 -89.33, 172.11 49.0, 84.75 70.86, 14.53 out-out out 12.88 Saltbr-out 9.64 HRD-in -63.98, -61.04 82.53, -9.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.58 APE8-rot-na 26.38 APE67-dihe-in -75.13, -4.52 -61.59, -34.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 2.5 0.276 0.319 B 331 291 17 0 0 17 [[712, 970]] 1.0 7jxw TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXWC 700 1007 1210.0 YY3:1301,VNS:1302 Type1,Type3 Inactive DFGin 4.644 14.309 BLBplus -142.67, 169.6 56.07, 43.83 -87.93, 169.01 48.26, 81.62 68.95, 14.82 out-out out 13.394 Saltbr-out 10.06 HRD-in -68.52, -63.21 83.53, -10.12 out-out-none SNCoon out-none ActLoopNT-out 9.372 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.99 APE8-dihe-in -72.85, 69.17 APE8-rot-na 25.57 APE67-dihe-in -79.13, -5.07 -61.58, -38.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.741 T790M,V948R None None XRAY 2.5 0.276 0.319 C 331 293 15 0 0 15 [[712, 970]] 1.0 7jxw TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXWD 700 1007 1210.0 YY3:1301,VNS:1302 Type1,Type3 Inactive DFGin 4.474 14.215 BLBplus -140.27, 167.25 54.64, 43.57 -89.93, 170.58 53.09, 83.38 70.73, 14.16 out-out out 13.287 Saltbr-out 10.176 HRD-in -66.78, -61.63 83.28, -9.7 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.01 APE8-dihe-in -78.05, 71.87 APE8-rot-na 25.04 APE67-dihe-in -75.98, -6.06 -65.38, -38.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.012 T790M,V948R None None XRAY 2.5 0.276 0.319 D 331 287 21 0 0 17 [[712, 970]] 1.0 7jxw TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8GK5A 701 1011 1210.0 Q6K:1101,YW5:1102 Type1,Type3 Inactive DFGin 4.808 14.912 BLBplus -132.77, 163.28 59.53, 50.36 -94.02, 166.24 50.17, 88.29 66.49, 24.24 out-out out 13.127 Saltbr-out 9.96 HRD-in -72.38, -54.99 79.4, -8.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.66 APE8-dihe-in -80.77, 69.75 APE8-rot-na 32.13 APE67-dihe-in -76.82, -3.31 -58.55, -37.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.087 T790M,V948R None None XRAY 2.3 0.224 0.252 A 331 294 17 0 0 17 [[712, 970]] 1.0 8gk5 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8GK5B 700 1008 1210.0 Q6K:1101,YW5:1102 Type1,Type3 Inactive DFGin 4.513 14.722 BLBplus -133.17, 164.36 59.73, 51.31 -91.4, 162.53 47.93, 87.21 64.33, 22.83 out-out out 13.093 Saltbr-out 12.438 HRD-in -72.73, -55.9 79.15, -8.43 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.91 APE8-dihe-in -79.02, 69.83 APE8-rot-na 32.01 APE67-dihe-in -76.26, -3.86 -58.1, -38.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.867 T790M,V948R None None XRAY 2.3 0.224 0.252 B 331 292 17 0 0 17 [[712, 970]] 1.0 8gk5 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8GK5C 700 1008 1210.0 Q6K:1101,YW5:1102 Type1,Type3 Inactive DFGin 4.465 14.758 BLBplus -134.6, 164.78 60.76, 50.7 -93.92, 162.62 46.93, 87.83 64.54, 21.99 out-out out 13.135 Saltbr-out 11.494 HRD-in -72.37, -55.98 79.27, -6.85 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.09 APE8-dihe-in -76.74, 68.64 APE8-rot-na 31.76 APE67-dihe-in -75.53, -4.34 -59.95, -38.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.102 T790M,V948R None None XRAY 2.3 0.224 0.252 C 331 293 16 0 0 16 [[712, 970]] 1.0 8gk5 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8GK5D 700 1008 1210.0 Q6K:1101,YW5:1102 Type1,Type3 Inactive DFGin 4.407 14.729 BLBplus -134.17, 163.98 61.67, 51.99 -93.03, 163.58 47.55, 87.87 65.01, 22.54 out-out out 13.091 Saltbr-out 12.29 HRD-in -70.88, -54.33 77.76, -8.04 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -1.54 APE9-dihe-in -75.57, 134.88 APE8-dihe-in -77.01, 71.98 APE8-rot-na 32.06 APE67-dihe-in -76.98, -3.79 -58.78, -38.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.721 APE9-dist-in 7.558 T790M,V948R None None XRAY 2.3 0.224 0.252 D 331 294 15 0 0 15 [[712, 970]] 1.0 8gk5 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6Z4BA 700 982 1210.0 Q6K:1101,9LL:1102 Type1,Type3 Inactive DFGin 5.693 14.816 BLBplus -133.89, 164.94 59.43, 51.96 -98.19, 144.81 41.57, 85.88 67.58, 19.62 out-none out 14.398 Saltbr-none 999.0 HRD-in -67.89, -64.09 87.77, -27.23 none-out-out SNCnoo out-out ActLoopNT-out 7.141 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -2.64 APE9-dihe-in -120.02, 130.13 APE8-dihe-in -80.9, 78.34 APE8-rot-na 31.39 APE67-dihe-in -73.81, -4.61 -60.28, -41.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.71 APE9-dist-out 8.134 T790M,V948R None None XRAY 2.5 0.222 0.251 A 333 271 12 0 0 12 [[712, 970]] 1.0 6z4b TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6Z4BB 699 984 1210.0 Q6K:1101,9LL:1102 Type1,Type3 Inactive DFGin 6.233 14.529 BLBplus -131.04, 166.01 60.41, 49.56 -101.97, 145.48 42.99, 86.21 -89.28, 999.0 out-out out 12.903 Saltbr-out 9.732 HRD-out -138.19, 95.22 -83.97, -17.5 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.87 APE8-dihe-in -88.45, 76.4 APE8-rot-na 32.2 APE67-dihe-in -72.84, -5.09 -59.16, -39.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.257 T790M,V948R None None XRAY 2.5 0.222 0.251 B 333 263 23 0 0 18 [[712, 970]] 1.0 6z4b TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6Z4DB 700 984 1210.0 8BS:1101,57N:1102 Type1,Type3 Inactive DFGin 5.216 14.759 BLBplus -130.83, 169.9 60.42, 43.34 -92.85, 149.61 47.56, 91.66 72.77, 15.07 out-none out 13.458 Saltbr-none 999.0 HRD-in -75.42, -54.52 82.84, -20.67 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 176.11 APE9-dihe-in -119.54, 129.26 APE8-dihe-in -76.04, 63.14 APE8-rot-na 30.86 APE67-dihe-in -72.75, -5.66 -53.62, -40.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.675 APE9-dist-out 8.425 T790M,V948R None None XRAY 2.0 0.195 0.221 B 333 270 15 0 0 15 [[712, 970]] 1.0 6z4d TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5GNKA 697 985 1210.0 80U:1001 Type1.5_Back Inactive DFGin 4.567 13.546 BLBplus -124.44, 160.99 73.54, 15.52 -61.64, 132.87 35.67, 94.83 87.34, -10.68 out-out out 12.136 Saltbr-out 9.468 HRD-in -71.44, -52.43 80.32, -11.88 out-out-out SNCooo out-out ActLoopNT-out 6.772 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 164.79 APE8-dihe-in -85.69, 72.36 APE8-rot-na 30.12 APE67-dihe-in -71.32, -14.07 -58.84, -38.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.046 T790M None None XRAY 1.796 0.166 0.177 A 297 277 12 0 0 12 [[712, 970]] 1.0 5gnk TYR_EGFR_HUMAN TYR 5.7e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6WA2A 699 1014 1210.0 TOV:1301 Type1.5_Back Inactive DFGin 4.044 14.259 BLBplus -130.21, 167.87 66.28, 28.26 -71.53, 137.79 56.13, 92.64 79.92, -10.79 out-out out 14.2 Saltbr-out 14.276 HRD-in -69.18, -54.46 82.51, -21.52 out-out-out SNCooo out-out ActLoopNT-out 6.808 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.16 APE8-dihe-in -69.52, 73.28 APE8-rot-na 28.29 APE67-dihe-in -78.42, 2.09 -58.73, -42.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.176 T790M,V948R None None XRAY 2.4 0.222 0.258 A 328 302 12 0 0 12 [[712, 970]] 1.0 6wa2 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6WA2B 701 1014 1210.0 TOV:1202 Type1.5_Back Inactive DFGin 3.853 14.507 BLBplus -130.44, 170.54 68.6, 27.89 -72.96, 137.09 58.49, 93.15 78.78, -11.36 out-out out 14.62 Saltbr-out 15.92 HRD-in -69.14, -54.27 84.16, -20.91 out-out-out SNCooo out-out ActLoopNT-out 7.16 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.22, -29.83 APE9-dihe-in -89.49, 122.81 APE8-dihe-in -80.98, 72.1 APE8-rot-na 32.79 APE67-dihe-in -78.49, 1.16 -58.92, -42.99 APE12-dist-na 17.625 APE11-dist-na 15.041 APE10-dist-na 11.119 APE9-dist-in 7.835 T790M,V948R None None XRAY 2.4 0.222 0.258 B 328 314 0 0 0 0 [[712, 970]] 1.0 6wa2 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6WA2C 701 1014 1210.0 TOV:1202 Type1.5_Back Inactive DFGin 3.59 15.223 BLBplus -129.9, 169.08 66.72, 27.67 -72.33, 138.28 81.68, 95.17 77.09, -11.93 out-out out 14.51 Saltbr-out 14.952 HRD-in -68.93, -54.81 83.12, -20.03 out-out-none SNCoon out-none ActLoopNT-out 6.51 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.6 APE8-dihe-in -75.46, 75.31 APE8-rot-na 31.12 APE67-dihe-in -77.15, 1.55 -57.9, -41.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.744 T790M,V948R None None XRAY 2.4 0.222 0.258 C 328 300 14 0 0 12 [[712, 970]] 1.0 6wa2 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6WA2D 701 1014 1210.0 TOV:1301 Type1.5_Back Inactive DFGin 4.037 14.22 BLBplus -130.83, 170.13 66.86, 27.29 -72.91, 137.99 57.49, 89.24 79.84, -11.2 out-out out 14.143 Saltbr-out 16.135 HRD-in -67.86, -54.75 83.33, -19.28 out-out-out SNCooo out-out ActLoopNT-out 6.745 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -72.34, 16.66 APE9-dihe-in -119.43, 121.09 APE8-dihe-in -82.59, 71.16 APE8-rot-na 32.34 APE67-dihe-in -79.04, 1.4 -59.51, -42.07 APE12-dist-na 18.026 APE11-dist-na 15.504 APE10-dist-na 11.15 APE9-dist-in 7.966 T790M,V948R None None XRAY 2.4 0.222 0.258 D 328 314 0 0 0 0 [[712, 970]] 1.0 6wa2 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8FV3C 701 1009 1210.0 YA6:1101 Type1.5_Back Inactive DFGin 4.976 14.226 BLBplus -140.28, 173.45 62.97, 49.98 -100.77, 147.39 44.76, 100.07 103.45, -165.1 out-out out 13.733 Saltbr-out 12.977 HRD-in -73.54, -54.95 81.69, -9.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 112.62 APE8-dihe-in -78.9, 67.7 APE8-rot-na 28.92 APE67-dihe-in -74.17, -1.93 -55.66, -42.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.207 T790M,V948R None None XRAY 2.1 0.191 0.226 C 328 291 18 0 0 17 [[712, 970]] 1.0 8fv3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8FV4D 701 1005 1210.0 YAA:1101 Type1.5_Back Inactive DFGin 4.336 14.193 BLBplus -131.61, 167.63 65.73, 30.81 -71.32, 133.31 54.39, 91.6 84.61, 0.99 out-out out 13.944 Saltbr-out 12.433 HRD-in -68.84, -58.76 79.63, -1.53 out-out-none SNCoon out-none ActLoopNT-out 7.083 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 100.68 APE8-dihe-in -73.69, 77.18 APE8-rot-na 31.74 APE67-dihe-in -70.65, -4.38 -67.28, -33.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.815 T790M,V948R None None XRAY 2.2 0.204 0.261 D 328 291 14 0 0 13 [[712, 970]] 1.0 8fv4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6TFUA 700 982 1210.0 N7K:1101 Type1.5_Back Inactive DFGin 4.427 13.864 BLBplus -130.16, 178.36 62.49, 31.16 -91.67, 140.32 64.62, 97.35 77.86, -17.11 out-out out 13.801 Saltbr-out 13.446 HRD-in -77.96, -51.4 79.0, -10.47 out-out-none SNCoon out-none ActLoopNT-out 8.182 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 113.15 APE8-dihe-in -73.63, 74.24 APE8-rot-na 30.82 APE67-dihe-in -74.45, -5.59 -56.1, -39.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.884 T790M,V948R None None XRAY 2.0 0.203 0.233 A 333 267 16 0 0 14 [[712, 970]] 1.0 6tfu TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6TFVA 700 985 1210.0 N7Q:1101 Type1.5_Back Inactive DFGin 4.801 14.042 BLBplus -127.87, 178.85 65.5, 33.25 -100.08, 161.84 66.11, 92.22 81.21, -6.69 out-none out 14.097 Saltbr-none 999.0 HRD-in -73.79, -54.39 81.21, -13.14 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 112.65 APE9-dihe-in -63.36, 128.89 APE8-dihe-in -78.52, 63.85 APE8-rot-na 34.33 APE67-dihe-in -76.0, -5.3 -53.35, -39.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.172 APE9-dist-in 7.816 T790M,V948R None None XRAY 1.5 0.184 0.203 A 333 269 17 0 0 16 [[712, 970]] 1.0 6tfv TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6TFVB 698 984 1210.0 N7Q:1105 Type1.5_Back Inactive DFGin 5.909 13.504 BLBplus -133.27, -177.3 66.71, 50.83 -134.53, -174.0 59.0, 89.26 81.06, -19.59 out-out out 13.563 Saltbr-out 12.152 HRD-in -76.67, -54.7 81.14, -9.97 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 145.82 APE9-dihe-in -98.3, 131.12 APE8-dihe-in -80.76, 67.11 APE8-rot-na 33.5 APE67-dihe-in -76.31, -4.36 -54.19, -40.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 16.478 APE9-dist-in 7.975 T790M,V948R None None XRAY 1.5 0.184 0.203 B 333 268 19 0 0 16 [[712, 970]] 1.0 6tfv TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6TFWA 700 982 1210.0 N7W:1101 Type1.5_Back Inactive DFGin 4.787 14.107 BLBplus -132.64, 176.54 61.0, 25.14 -85.77, 143.95 61.55, 92.16 66.16, 16.86 out-out out 13.947 Saltbr-out 13.149 HRD-in -74.82, -54.24 72.68, 8.63 out-out-none SNCoon out-none ActLoopNT-out 8.163 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -86.61 APE9-dihe-in -122.2, 137.57 APE8-dihe-in -75.44, 74.31 APE8-rot-na 30.35 APE67-dihe-in -70.83, -4.37 -56.59, -44.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.952 APE9-dist-in 7.42 T790M,V948R None None XRAY 2.0 0.224 0.245 A 333 266 17 0 0 14 [[712, 970]] 1.0 6tfw TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6TFWB 700 984 1210.0 N7W:1105 Type1.5_Back Inactive DFGin 5.473 13.953 BLBplus -136.84, -176.85 60.1, 54.53 -129.66, 147.25 61.08, 91.4 89.61, 999.0 out-out out 13.675 Saltbr-out 11.805 HRD-in -71.22, -49.17 82.6, -11.99 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 110.05 APE8-dihe-in -75.27, 77.65 APE8-rot-na 29.93 APE67-dihe-in -72.87, -8.08 -59.24, -42.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.022 T790M,V948R None None XRAY 2.0 0.224 0.245 B 333 264 21 0 0 18 [[712, 970]] 1.0 6tfw TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6TFYB 699 984 1210.0 N7Z:1104 Type1.5_Back Inactive DFGin 5.537 13.915 BLBplus -129.47, -176.79 65.55, 50.72 -133.13, 168.46 63.91, 95.78 94.18, 6.69 out-out out 13.522 Saltbr-out 11.964 HRD-in -72.76, -56.5 77.72, -7.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.32 APE8-dihe-in -81.35, 62.3 APE8-rot-na 33.43 APE67-dihe-in -71.59, -7.13 -54.96, -40.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.37 T790M,V948R None None XRAY 1.7 0.193 0.212 B 333 264 22 0 0 17 [[712, 970]] 1.0 6tfy TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6TFZA 701 982 1210.0 N7B:1101 Type1.5_Back Inactive DFGin 4.81 14.039 BLBplus -131.17, 176.76 66.24, 32.71 -90.96, 157.66 58.34, 95.96 78.65, -5.02 out-none out 13.738 Saltbr-none 999.0 HRD-in -73.66, -52.65 76.67, -10.13 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 62.7 APE9-dihe-in -78.68, 135.58 APE8-dihe-in -80.74, 62.33 APE8-rot-na 36.82 APE67-dihe-in -73.76, -8.98 -52.23, -40.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.266 APE9-dist-in 7.991 T790M,V948R None None XRAY 1.8 0.176 0.206 A 333 264 18 0 0 16 [[712, 970]] 1.0 6tfz TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6TFZB 700 984 1210.0 N7B:1101 Type1.5_Back Inactive DFGin 5.918 13.336 BLBplus -137.17, -171.23 63.4, 43.24 -124.37, 167.57 57.63, 93.3 72.74, -129.39 out-none out 13.556 Saltbr-none 999.0 HRD-in -71.16, -57.76 83.58, -14.25 none-out-none SNCnon out-none ActLoopNT-out 9.804 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 154.49 APE8-dihe-in -82.81, 72.07 APE8-rot-na 33.88 APE67-dihe-in -76.45, -4.79 -54.88, -38.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.708 T790M,V948R None None XRAY 1.8 0.176 0.206 B 333 271 14 0 0 14 [[712, 970]] 1.0 6tfz TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6TG0A 700 985 1210.0 N78:1101 Type1.5_Back Inactive DFGin 5.751 14.369 BLBplus -135.18, -174.71 67.55, 51.68 -142.66, 170.72 64.3, 92.15 77.6, 999.0 out-out out 14.056 Saltbr-out 12.766 HRD-in -71.97, -56.05 80.78, -8.56 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.61 APE8-dihe-in -78.26, 65.34 APE8-rot-na 35.68 APE67-dihe-in -76.24, -6.42 -52.05, -40.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.566 T790M,V948R None None XRAY 1.5 0.174 0.188 A 333 267 19 0 0 18 [[712, 970]] 1.0 6tg0 TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6TG0B 698 984 1210.0 N78:1105 Type1.5_Back Inactive DFGin 6.259 13.66 BLBplus -137.8, -176.41 66.01, 56.66 -142.67, 173.28 62.89, 93.05 72.69, -137.17 out-out out 13.47 Saltbr-out 11.795 HRD-in -71.39, -56.76 81.41, -11.24 out-out-none SNCoon out-none ActLoopNT-out 9.898 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -3.99 APE9-dihe-in -123.88, 117.15 APE8-dihe-in -83.72, 66.18 APE8-rot-na 34.91 APE67-dihe-in -75.21, -6.99 -52.62, -41.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.935 APE9-dist-in 7.36 T790M,V948R None None XRAY 1.5 0.174 0.188 B 333 276 11 0 0 11 [[712, 970]] 1.0 6tg0 TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6TG1A 699 984 1210.0 N82:1101 Type1.5_Back Inactive DFGin 5.884 14.313 BLBplus -135.09, -174.82 67.14, 52.49 -145.29, 161.02 65.35, 90.59 96.92, 999.0 out-out out 14.061 Saltbr-out 13.148 HRD-in -73.8, -54.65 80.6, -11.14 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.01 APE8-dihe-in -83.61, 66.82 APE8-rot-na 36.14 APE67-dihe-in -74.2, -5.59 -56.71, -41.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.347 T790M,V948R None None XRAY 1.6 0.182 0.198 A 333 268 18 0 0 18 [[712, 970]] 1.0 6tg1 TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6TG1B 698 984 1210.0 N82:1101 Type1.5_Back Inactive DFGin 5.972 14.365 BLBplus -131.9, -167.09 65.39, 54.65 -153.53, 171.0 69.57, 91.23 106.74, -17.72 out-none out 13.59 Saltbr-none 999.0 HRD-in -72.65, -58.62 83.23, 2.46 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.94 APE8-dihe-in -81.28, 62.75 APE8-rot-na 33.22 APE67-dihe-in -73.65, -5.87 -52.25, -41.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.307 T790M,V948R None None XRAY 1.6 0.182 0.198 B 333 271 16 0 0 16 [[712, 970]] 1.0 6tg1 TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2JIVB 699 982 1210.0 HKI:1797 Type1.5_Back Inactive DFGin 5.077 13.748 BLBplus -147.04, -173.33 50.03, 19.5 -76.15, 164.05 47.98, 89.4 34.92, 16.92 out-out out 14.258 Saltbr-out 14.063 HRD-in -76.44, -8.74 29.89, 32.3 out-out-out SNCooo out-out ActLoopNT-out 6.582 ActLoopCT-out TYR APEdihe_ooiai APEdist_aaao APE10-dihe-out -61.7, 27.79 APE9-dihe-out -57.93, -177.94 APE8-dihe-in -111.79, 65.27 APE8-rot-na 347.45 APE67-dihe-in -88.48, -47.11 -56.32, 0.62 APE12-dist-na 15.291 APE11-dist-na 15.522 APE10-dist-na 14.783 APE9-dist-out 8.197 T790M None None XRAY 3.5 0.253 0.284 B 328 272 12 0 0 11 [[712, 970]] 1.0 2jiv TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5GTYB 700 1014 1210.0 816:1101 Type1.5_Back Inactive DFGin 4.29 14.347 BLBplus -138.92, 165.68 84.63, 3.85 -68.43, 135.48 78.45, 90.03 81.71, -3.27 out-out out 13.492 Saltbr-out 15.599 HRD-out -95.29, 124.61 -62.89, -41.97 out-out-out SNCooo out-out ActLoopNT-out 7.06 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -99.53 APE9-dihe-in -66.19, 150.26 APE8-dihe-in -83.76, 84.04 APE8-rot-na 28.01 APE67-dihe-in -63.91, -38.81 -63.74, -37.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.154 APE9-dist-out 9.305 T790M None None XRAY 3.14 0.258 0.28 B 331 299 16 0 0 12 [[712, 970]] 1.0 5gty TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5GTYD 701 1014 1210.0 816:1101 Type1.5_Back Inactive DFGin 3.744 14.902 BLBplus -133.78, 167.12 81.14, 4.97 -64.51, 133.85 87.51, 89.95 82.67, -5.26 out-out out 14.125 Saltbr-out 12.581 HRD-in -64.22, -47.55 79.94, -12.61 out-out-out SNCooo out-out ActLoopNT-out 6.18 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 35.49 APE9-dihe-in -128.38, 151.23 APE8-dihe-in -84.12, 67.79 APE8-rot-na 27.63 APE67-dihe-in -63.81, -37.49 -62.48, -38.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.155 APE9-dist-out 8.324 T790M None None XRAY 3.14 0.258 0.28 D 331 297 17 0 0 12 [[712, 970]] 1.0 5gty TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5GTYE 701 1014 1210.0 816:1101 Type1.5_Back Inactive DFGin 4.06 15.401 BLBplus -130.28, 163.95 73.19, 13.87 -64.73, 129.08 103.21, 59.68 78.99, -3.66 out-none out 13.741 Saltbr-none 999.0 HRD-in -63.53, -39.57 73.37, -57.08 none-out-out SNCnoo out-out ActLoopNT-out 5.679 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -16.57 APE9-dihe-in -63.24, 143.82 APE8-dihe-in -84.53, 69.95 APE8-rot-na 27.95 APE67-dihe-in -63.25, -38.96 -61.88, -39.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.901 APE9-dist-out 9.111 T790M None None XRAY 3.14 0.258 0.28 E 331 297 17 0 0 12 [[712, 970]] 1.0 5gty TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5GTYG 699 1014 1210.0 816:1101 Type1.5_Back Inactive DFGin 5.067 14.626 BLBplus -143.11, 179.85 58.12, 44.59 -112.54, 128.63 59.94, 74.31 85.4, 3.0 out-out out 14.3 Saltbr-out 16.006 HRD-in -64.4, -40.83 72.49, -56.78 out-out-out SNCooo out-out ActLoopNT-out 7.055 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 152.17 APE9-dihe-in -112.88, 128.29 APE8-dihe-in -84.62, 80.89 APE8-rot-na 19.82 APE67-dihe-in -63.68, -40.43 -63.75, -39.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.262 APE9-dist-out 9.052 T790M None None XRAY 3.14 0.258 0.28 G 331 299 17 0 0 12 [[712, 970]] 1.0 5gty TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5GTYH 700 1016 1210.0 816:1101 Type1.5_Back Inactive DFGin 4.464 14.996 BLBplus -155.19, 174.62 58.89, 40.9 -106.98, 132.32 74.94, 82.26 87.03, 0.91 out-out out 14.092 Saltbr-out 15.791 HRD-in -64.35, -48.45 80.9, -10.31 out-out-out SNCooo out-out ActLoopNT-out 6.834 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 6.3 APE9-dihe-in -114.67, 127.92 APE8-dihe-in -87.4, 86.48 APE8-rot-na 29.16 APE67-dihe-in -62.99, -38.55 -63.72, -40.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.525 APE9-dist-out 8.734 T790M None None XRAY 3.14 0.258 0.28 H 331 300 16 0 0 12 [[712, 970]] 1.0 5gty TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3W2RA 698 1017 1210.0 W2R:1101 Type1.5_Back Inactive DFGin 4.449 12.33 BLBplus -137.59, 178.08 54.95, 38.03 -65.53, 155.88 47.33, 82.4 -65.44, 174.26 out-out out 11.302 Saltbr-out 9.806 HRD-in -74.49, -53.66 81.5, -16.32 out-out-none SNCoon out-none ActLoopNT-out 7.869 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.04 APE8-dihe-in -78.09, 65.46 APE8-rot-na 29.85 APE67-dihe-in -79.31, 0.09 -47.47, -44.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.899 T790M,L858R None None XRAY 2.05 0.22 0.275 A 331 297 14 0 0 14 [[712, 970]] 1.0 3w2r TYR_EGFR_HUMAN TYR 8.7e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2RGPA 702 1016 1210.0 HYZ:1 Type1.5_Back Inactive DFGin 4.639 13.972 BLBplus -140.95, 177.84 65.47, 21.11 -77.76, 153.7 43.68, 94.35 83.07, -34.52 out-out out 13.729 Saltbr-out 12.982 HRD-in -65.03, -54.97 78.42, -10.72 out-out-none SNCoon out-none ActLoopNT-out 6.364 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.81 APE8-dihe-in -76.74, 62.82 APE8-rot-na 346.55 APE67-dihe-in -70.49, -6.2 -47.73, -43.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.962 None None None XRAY 2.0 0.228 0.268 A 315 284 17 0 0 8 [[712, 970]] 1.0 2rgp TYR_EGFR_HUMAN TYR 9.2e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3BELA 702 1015 1210.0 POX:1 Type1.5_Back Inactive DFGin 4.429 13.975 BLBplus -144.0, 174.65 70.44, 15.84 -72.96, 152.06 48.87, 90.91 82.19, -30.43 out-out out 13.888 Saltbr-out 13.489 HRD-in -59.26, -60.02 83.7, -7.04 out-out-none SNCoon out-none ActLoopNT-out 6.315 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.28 APE8-dihe-in -78.06, 64.55 APE8-rot-na 39.14 APE67-dihe-in -67.84, -7.09 -49.38, -46.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.992 None None None XRAY 2.3 0.241 0.281 A 315 280 18 0 0 8 [[712, 970]] 1.0 3bel TYR_EGFR_HUMAN TYR 9.2e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8PO4A 700 1014 1210.0 26X:1101 Type1.5_Back Inactive DFGin 6.414 12.877 BLBplus -129.71, 175.35 61.58, 31.97 -84.17, 147.82 49.64, 93.29 52.87, 31.63 out-out out 14.96 Saltbr-out 16.421 HRD-in -66.94, -58.73 81.99, -13.79 out-out-out SNCooo out-out ActLoopNT-out 6.901 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.59 APE8-dihe-in -76.52, 64.66 APE8-rot-na 30.38 APE67-dihe-in -71.47, -7.3 -48.65, -42.92 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.097 V948R None None XRAY 1.621 0.211 0.243 A 328 307 8 0 0 8 [[712, 970]] 1.0 8po4 TYR_EGFR_HUMAN TYR 7.9e-88 300.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3LZBA 703 983 1210.0 ITI:60001 Type1.5_Back Inactive DFGin 4.413 14.113 BLBplus -125.13, 176.44 56.08, 40.39 -84.19, 136.21 42.68, 101.81 78.32, 7.67 out-out out 14.281 Saltbr-out 16.067 HRD-in -64.02, -64.87 94.19, -31.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 170.85 APE9-dihe-in -92.26, 121.26 APE8-dihe-in -64.31, 51.85 APE8-rot-na 8.36 APE67-dihe-in -68.59, -1.05 -39.19, -47.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.357 APE9-dist-out 8.223 V948R None None XRAY 2.7 0.206 0.257 A 327 265 16 0 0 16 [[712, 970]] 1.0 3lzb TYR_EGFR_HUMAN TYR 7.8e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3LZBB 703 983 1210.0 ITI:60001 Type1.5_Back Inactive DFGin 4.381 13.959 BLBplus -119.7, -179.35 54.89, 41.32 -86.82, 133.57 41.54, 106.13 73.46, 9.05 out-out out 14.275 Saltbr-out 16.097 HRD-in -65.79, -60.12 87.79, -17.38 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 175.31 APE9-dihe-in -89.1, 120.24 APE8-dihe-in -68.59, 65.01 APE8-rot-na 30.46 APE67-dihe-in -68.36, -3.12 -48.63, -40.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.171 APE9-dist-in 7.817 V948R None None XRAY 2.7 0.206 0.257 B 327 265 16 0 0 16 [[712, 970]] 1.0 3lzb TYR_EGFR_HUMAN TYR 7.8e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3LZBC 704 983 1210.0 ITI:60001 Type1.5_Back Inactive DFGin 4.388 14.034 BLBplus -132.56, 174.78 57.2, 36.27 -81.82, 140.08 44.1, 102.6 73.85, 8.44 out-out out 13.853 Saltbr-out 16.045 HRD-in -67.43, -53.65 76.74, -16.56 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 172.19 APE9-dihe-in -92.55, 117.86 APE8-dihe-in -70.59, 65.45 APE8-rot-na 30.7 APE67-dihe-in -69.07, -2.07 -45.86, -43.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.409 APE9-dist-in 7.638 V948R None None XRAY 2.7 0.206 0.257 C 327 259 21 0 0 16 [[712, 970]] 1.0 3lzb TYR_EGFR_HUMAN TYR 7.8e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3LZBD 703 983 1210.0 ITI:60001 Type1.5_Back Inactive DFGin 4.542 14.207 BLBplus -128.51, 168.04 64.67, 28.61 -76.12, 143.44 45.13, 102.55 72.45, 3.46 out-out out 14.931 Saltbr-out 17.043 HRD-in -64.23, -56.15 80.94, -21.59 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -168.64 APE9-dihe-in -94.62, 117.93 APE8-dihe-in -68.62, 65.64 APE8-rot-na 31.36 APE67-dihe-in -68.52, -3.42 -48.32, -42.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.196 APE9-dist-in 7.812 V948R None None XRAY 2.7 0.206 0.257 D 327 261 20 0 0 16 [[712, 970]] 1.0 3lzb TYR_EGFR_HUMAN TYR 7.8e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3POZA 701 1017 1210.0 03P:1023 Type1.5_Back Inactive DFGin 4.451 13.643 BLBplus -134.04, 177.92 66.76, 22.09 -77.01, 146.77 49.04, 92.91 73.32, 4.89 out-out out 14.048 Saltbr-out 14.594 HRD-in -70.57, -55.32 77.16, -8.09 out-out-none SNCoon out-none ActLoopNT-out 6.294 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 142.54 APE9-dihe-in -117.89, 144.54 APE8-dihe-in -79.69, 70.35 APE8-rot-na 31.29 APE67-dihe-in -71.87, -5.08 -51.91, -42.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.87 APE9-dist-in 7.568 None None None XRAY 1.5 0.22 0.243 A 327 293 18 0 0 7 [[712, 970]] 1.0 3poz TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3W2SA 701 1019 1210.0 W2R:1101 Type1.5_Back Inactive DFGin 4.791 13.496 BLBplus -137.24, -178.36 61.1, 30.66 -95.07, 163.05 54.49, 90.43 79.34, 159.34 out-out out 14.307 Saltbr-out 13.317 HRD-in -69.79, -50.96 77.18, -17.46 out-out-out SNCooo out-out ActLoopNT-out 7.351 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 138.15 APE9-dihe-in -81.88, 121.8 APE8-dihe-in -75.83, 61.34 APE8-rot-na 27.79 APE67-dihe-in -72.23, -7.73 -51.73, -42.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 15.728 APE9-dist-out 8.291 None None None XRAY 1.9 0.207 0.258 A 330 307 12 0 0 12 [[712, 970]] 1.0 3w2s TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3W32A 701 1017 1210.0 W32:1101 Type1.5_Back Inactive DFGin 4.654 13.377 BLBplus -134.93, 174.75 75.62, 15.73 -74.59, 136.0 48.33, 88.42 85.13, 3.49 out-out out 14.094 Saltbr-out 13.598 HRD-in -69.8, -59.18 76.05, -4.36 out-out-in SNCooi out-in ActLoopNT-out 6.242 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.7, 158.18 APE9-dihe-in -131.47, 158.06 APE8-dihe-in -79.68, 77.14 APE8-rot-na 27.77 APE67-dihe-in -73.57, -6.08 -55.16, -38.17 APE12-dist-na 16.516 APE11-dist-na 12.808 APE10-dist-na 13.448 APE9-dist-in 7.197 None None None XRAY 1.8 0.202 0.236 A 330 317 0 0 0 0 [[712, 970]] 1.0 3w32 TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3W33A 701 1018 1210.0 W19:1101 Type1.5_Back Inactive DFGin 4.713 13.306 BLBplus -137.46, -177.59 63.41, 25.25 -82.13, 140.46 46.7, 89.54 72.41, 8.85 out-out out 14.305 Saltbr-out 15.578 HRD-in -70.28, -56.62 80.46, -14.05 out-out-none SNCoon out-none ActLoopNT-out 6.735 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 102.54 APE9-dihe-in -105.56, 138.68 APE8-dihe-in -74.54, 70.67 APE8-rot-na 26.75 APE67-dihe-in -78.38, -6.64 -55.74, -35.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.105 APE9-dist-in 7.859 None None None XRAY 1.7 0.199 0.233 A 330 297 17 0 0 12 [[712, 970]] 1.0 3w33 TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
1XKKA 702 1018 1210.0 FMM:91 Type1.5_Back Inactive DFGin 4.633 13.862 BLBplus -142.44, -178.32 66.71, 16.01 -82.53, 163.31 49.94, 92.67 85.22, -36.9 out-out out 13.318 Saltbr-out 13.504 HRD-in -57.62, -56.43 78.67, -6.78 out-out-out SNCooo out-out ActLoopNT-out 6.262 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 94.63 APE8-dihe-out -68.36, 44.76 APE8-rot-na 338.83 APE67-dihe-in -77.24, -6.92 -41.16, -39.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.332 None None None XRAY 2.4 0.209 0.255 A 352 289 16 0 0 8 [[712, 970]] 1.0 1xkk TYR_EGFR_HUMAN TYR 1.3e-87 299.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8PO1A 699 984 1210.0 2EI:61101 Type1.5_Back Inactive DFGin 9.117 13.761 BLBplus -125.95, 174.55 63.29, 27.9 -79.94, 142.02 40.25, 91.32 70.27, 11.76 out-out out 15.823 Saltbr-out 16.526 HRD-in -64.69, -54.66 73.39, -11.95 out-out-none SNCoon out-none ActLoopNT-out 6.807 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 110.41 APE8-dihe-in -78.71, 67.67 APE8-rot-na 28.95 APE67-dihe-in -72.75, -5.56 -46.63, -44.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.854 V948R None None XRAY 2.11 0.253 0.275 A 332 274 12 0 0 12 [[712, 970]] 1.0 8po1 TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8PO2A 705 984 1210.0 26X:61101 Type1.5_Back Inactive DFGin 8.434 13.424 BLBplus -127.32, 170.0 62.53, 23.96 -71.08, 137.71 39.46, 86.24 60.84, 7.23 out-out out 16.74 Saltbr-out 16.215 HRD-in -57.53, -58.75 81.17, -7.29 out-out-none SNCoon out-none ActLoopNT-out 6.851 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 109.54 APE8-dihe-in -73.86, 76.5 APE8-rot-na 29.52 APE67-dihe-in -70.72, -9.55 -57.41, -38.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.881 V948R None None XRAY 2.28 0.196 0.246 A 332 268 12 0 0 12 [[712, 970]] 1.0 8po2 TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8PO2B 702 984 1210.0 26X:61101 Type1.5_Back Inactive DFGin 8.069 13.788 BLBplus -112.88, 172.51 68.29, 13.84 -71.64, 140.71 51.27, 88.14 70.36, 3.83 out-out out 16.4 Saltbr-out 16.068 HRD-in -71.57, -60.59 82.79, -10.73 out-out-none SNCoon out-none ActLoopNT-out 6.737 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.17 APE8-dihe-in -79.43, 73.37 APE8-rot-na 31.37 APE67-dihe-in -68.51, -4.77 -58.78, -46.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.845 V948R None None XRAY 2.28 0.196 0.246 B 332 271 12 0 0 12 [[712, 970]] 1.0 8po2 TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9EWSA 703 984 1210.0 A1H7N:61101 Type1.5_Back Inactive DFGin 5.652 13.831 BLBplus -124.76, 171.69 64.56, 37.53 -90.55, 139.48 51.46, 89.18 73.73, -4.13 out-out out 15.397 Saltbr-out 13.594 HRD-in -50.82, -55.36 72.45, -9.66 out-out-none SNCoon out-none ActLoopNT-out 6.098 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 104.58 APE8-dihe-in -81.99, 76.73 APE8-rot-na 31.18 APE67-dihe-in -64.5, 7.66 -49.18, -51.24 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.539 V948R None None XRAY 2.435 0.23 0.326 A 332 270 12 0 0 12 [[712, 970]] 1.0 9ews TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9EWTA 703 984 1210.0 A1H7O:61101 Type1.5_Back Inactive DFGin 7.52 13.282 BLBplus -126.22, 168.9 67.49, 27.27 -77.28, 137.19 37.5, 85.6 57.97, 18.29 out-out out 16.063 Saltbr-out 16.774 HRD-in -64.15, -44.83 71.6, -39.03 out-out-out SNCooo out-out ActLoopNT-out 6.132 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.93 APE8-dihe-in -66.6, 94.08 APE8-rot-na 23.81 APE67-dihe-in -68.36, -26.48 -72.94, -33.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.455 V948R None None XRAY 3.019 0.238 0.342 A 332 270 12 0 0 12 [[712, 970]] 1.0 9ewt TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9EWTB 703 984 1210.0 A1H7O:61101 Type1.5_Back Inactive DFGin 7.48 12.417 BLBplus -127.27, 169.71 57.86, 28.37 -72.42, 129.96 42.21, 100.6 74.66, -18.63 out-out out 15.176 Saltbr-out 16.331 HRD-in -58.87, -43.22 64.98, -9.53 out-out-none SNCoon out-none ActLoopNT-out 6.209 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.78 APE8-dihe-in -75.53, 79.59 APE8-rot-na 28.36 APE67-dihe-in -57.45, -45.92 -56.17, -38.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.505 V948R None None XRAY 3.019 0.238 0.342 B 332 270 12 0 0 12 [[712, 970]] 1.0 9ewt TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9GC4A 703 984 1210.0 A1IZ7:61101 Type1.5_Back Inactive DFGin 5.441 13.105 BLBplus -109.8, 172.26 66.58, 31.46 -76.63, 144.79 41.68, 86.31 67.13, 5.16 out-out out 14.238 Saltbr-out 16.474 HRD-in -70.19, -48.03 77.36, -13.98 out-out-out SNCooo out-out ActLoopNT-out 7.108 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -83.34, -21.98 APE9-dihe-in -66.5, 130.36 APE8-dihe-in -82.93, 68.65 APE8-rot-na 28.49 APE67-dihe-in -78.96, 0.06 -56.31, -35.6 APE12-dist-na 17.12 APE11-dist-na 17.207 APE10-dist-na 12.588 APE9-dist-out 8.271 V948R None None XRAY 2.415 0.218 0.248 A 332 282 0 0 0 0 [[712, 970]] 1.0 9gc4 TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9GC4B 703 984 1210.0 A1IZ7:61101 Type1.5_Back Inactive DFGin 4.916 13.352 BLBplus -109.37, 174.94 66.51, 23.29 -75.86, 137.04 48.21, 94.45 85.45, -20.15 out-out out 14.478 Saltbr-out 14.461 HRD-in -67.81, -57.01 77.79, -1.27 out-out-out SNCooo out-out ActLoopNT-out 6.407 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -91.21, 3.02 APE9-dihe-in -94.27, 129.32 APE8-dihe-in -83.53, 68.53 APE8-rot-na 28.65 APE67-dihe-in -77.55, -0.63 -56.32, -35.82 APE12-dist-na 16.945 APE11-dist-na 16.877 APE10-dist-na 12.32 APE9-dist-out 8.141 V948R None None XRAY 2.415 0.218 0.248 B 332 282 0 0 0 0 [[712, 970]] 1.0 9gc4 TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9HBOA 702 986 1210.0 A1IUK:61101 Type1.5_Back Inactive DFGin 5.205 13.501 BLBplus -119.94, 175.34 66.34, 20.96 -73.32, 136.12 49.79, 85.71 78.53, -8.02 out-none out 13.985 Saltbr-none 999.0 HRD-in -66.69, -51.95 79.88, -14.14 none-out-out SNCnoo out-out ActLoopNT-out 6.899 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 118.12 APE9-dihe-in -76.23, 133.71 APE8-dihe-in -83.6, 64.85 APE8-rot-na 29.55 APE67-dihe-in -72.82, -1.73 -50.01, -41.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.553 APE9-dist-out 8.321 V948R None None XRAY 2.45 0.228 0.255 A 332 274 11 0 0 11 [[712, 970]] 1.0 9hbo TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9HBOB 702 985 1210.0 A1IUK:61101 Type1.5_Back Inactive DFGin 5.178 13.613 BLBplus -119.57, 175.0 66.78, 20.15 -72.91, 140.31 50.15, 87.63 76.53, -8.09 out-none out 13.868 Saltbr-none 999.0 HRD-in -66.74, -52.01 79.37, -12.83 none-out-out SNCnoo out-out ActLoopNT-out 6.665 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -114.41, 116.5 APE9-dihe-in -78.42, 132.58 APE8-dihe-in -84.37, 63.76 APE8-rot-na 29.82 APE67-dihe-in -72.45, -2.09 -49.92, -41.53 APE12-dist-na 999.0 APE11-dist-na 13.533 APE10-dist-na 14.554 APE9-dist-out 8.405 V948R None None XRAY 2.45 0.228 0.255 B 332 278 6 0 0 6 [[712, 970]] 1.0 9hbo TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6WAKC 701 1014 1210.0 TQA:1301 Type1.5_Front Inactive DFGin 4.108 14.307 BLBplus -128.74, 170.35 57.84, 42.31 -80.67, 146.74 56.84, 84.42 73.11, 52.84 out-out out 13.687 Saltbr-out 13.168 HRD-in -69.35, -57.7 81.97, -4.79 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -99.43 APE9-dihe-in -140.88, 118.68 APE8-dihe-in -72.34, 69.57 APE8-rot-na 41.21 APE67-dihe-in -76.32, 0.41 -56.53, -41.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.489 APE9-dist-out 8.042 T790M,V948R None None XRAY 2.4 0.219 0.23 C 328 299 15 0 0 15 [[712, 970]] 1.0 6wak TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6WXNC 701 1014 1210.0 UEJ:1301 Type1.5_Front Inactive DFGin 5.149 14.242 BLBplus -125.79, 168.58 69.11, 30.42 -73.13, 126.76 42.33, 95.66 91.61, -9.41 out-out out 13.559 Saltbr-out 12.827 HRD-in -75.25, -56.93 84.93, -23.09 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.4 APE8-dihe-in -83.07, 65.64 APE8-rot-na 32.78 APE67-dihe-in -77.0, -5.94 -52.82, -37.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.347 T790M,V948R None None XRAY 1.76 0.209 0.235 C 328 286 28 0 0 16 [[712, 970]] 1.0 6wxn TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6WXND 702 1014 1210.0 UEJ:1101 Type1.5_Front Inactive DFGin 5.021 14.15 BLBplus -127.07, 163.26 73.25, 22.29 -63.33, 141.68 45.73, 93.45 80.75, -14.01 out-out out 13.653 Saltbr-out 13.598 HRD-in -75.42, -56.41 82.09, -17.01 out-out-none SNCoon out-none ActLoopNT-out 6.661 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.16 APE8-dihe-in -83.51, 70.14 APE8-rot-na 34.07 APE67-dihe-in -73.61, -7.52 -55.72, -38.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.723 T790M,V948R None None XRAY 1.76 0.209 0.235 D 328 292 16 0 0 13 [[712, 970]] 1.0 6wxn TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8TO3A 702 1007 1210.0 IXC:1101 Type1.5_Front Inactive DFGin 4.371 13.996 BLBplus -135.94, 169.11 67.48, 22.01 -70.94, 138.5 62.13, 97.63 90.56, 75.28 out-out out 13.482 Saltbr-out 16.432 HRD-in -64.1, -62.98 87.72, -19.67 out-out-out SNCooo out-out ActLoopNT-out 8.667 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.18 APE8-dihe-in -84.44, 67.85 APE8-rot-na 34.08 APE67-dihe-in -75.79, -1.46 -59.58, -38.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.492 T790M,V948R None None XRAY 2.49 0.231 0.269 A 328 291 15 0 0 15 [[712, 970]] 1.0 8to3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7LG8B 702 1002 1210.0 VNS:1101,8RC:1102 Type1.5_Front,Type1 Inactive DFGin 4.918 14.797 BLBplus -141.19, 170.16 49.38, 57.43 -105.85, 156.28 47.74, 86.43 72.05, 29.16 out-out out 13.829 Saltbr-out 11.399 HRD-in -68.62, -56.52 80.22, -7.8 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 72.88 APE9-dihe-in -61.52, 127.34 APE8-dihe-in -70.71, 68.41 APE8-rot-na 28.03 APE67-dihe-in -75.05, -4.72 -60.67, -37.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.938 APE9-dist-out 8.676 T790M,V948R None None XRAY 2.93 0.237 0.27 B 331 275 15 0 0 15 [[712, 970]] 1.0 7lg8 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5ZWJA 702 985 1210.0 9LL:1101 Type3 Inactive DFGin 5.542 14.462 BLBplus -134.76, 169.78 70.33, 21.35 -80.26, 157.71 46.02, 86.11 85.63, 6.58 out-none out 12.365 Saltbr-none 999.0 HRD-in -62.57, -46.38 74.18, -0.41 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 170.69 APE8-dihe-in -84.81, 75.57 APE8-rot-na 34.77 APE67-dihe-in -62.54, -42.94 -62.02, -41.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.058 T790M,C797S,V948R None None XRAY 2.9 0.256 0.272 A 355 267 17 0 0 17 [[712, 970]] 1.0 5zwj TYR_EGFR_HUMAN TYR 5.9e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8A2BA 702 990 1210.0 KY9:1101 Type3 Inactive DFGin 5.426 14.435 BLBplus -143.53, -174.33 44.34, 37.79 -92.75, 167.36 44.38, 91.12 110.41, -145.91 out-out out 13.246 Saltbr-out 12.26 HRD-in -75.49, -60.69 77.7, -7.21 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.84 APE8-dihe-in -84.13, 67.89 APE8-rot-na 33.21 APE67-dihe-in -76.37, -2.66 -52.66, -40.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.066 L858R,V948R None None XRAY 1.69 0.212 0.258 A 326 272 17 0 0 17 [[712, 970]] 1.0 8a2b TYR_EGFR_HUMAN TYR 8.1e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6P1DC 702 1006 1210.0 NQ1:1101,ANP:1102 Type3,ATPlike Inactive DFGin 5.383 14.459 BLBplus -142.0, 171.97 66.8, 29.01 -86.08, 152.7 44.82, 92.23 73.36, -11.9 out-out out 13.614 Saltbr-out 13.736 HRD-in -69.23, -60.69 76.65, -2.9 out-out-none SNCoon out-none ActLoopNT-out 6.785 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.45 APE8-dihe-in -76.51, 79.09 APE8-rot-na 31.04 APE67-dihe-in -75.49, -1.74 -58.74, -40.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.258 None None None XRAY 2.4 0.195 0.213 C 327 292 13 0 0 13 [[712, 970]] 1.0 6p1d TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6P1DD 701 1008 1210.0 NQ1:1101,ANP:1102 Type3,ATPlike Inactive DFGin 4.796 14.102 BLBplus -132.01, 171.13 65.01, 17.93 -68.87, 143.86 51.94, 90.04 79.55, -15.22 out-out out 13.622 Saltbr-out 13.734 HRD-in -75.21, -58.43 80.83, -11.58 out-out-none SNCoon out-none ActLoopNT-out 6.633 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.5 APE8-dihe-in -78.23, 70.43 APE8-rot-na 33.16 APE67-dihe-in -74.16, -5.23 -50.48, -45.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.251 None None None XRAY 2.4 0.195 0.213 D 327 295 13 0 0 13 [[712, 970]] 1.0 6p1d TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXQA 700 1007 1210.0 VNS:1102,ANP:1103 Type3,ATPlike Inactive DFGin 4.86 14.542 BLBplus -136.59, 171.99 58.78, 36.07 -93.08, 163.3 53.5, 85.99 81.0, 16.2 out-out out 13.6 Saltbr-out 11.402 HRD-in -66.89, -59.97 80.26, -12.87 out-out-out SNCooo out-out ActLoopNT-out 8.834 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 0.37 APE9-dihe-in -62.95, 136.95 APE8-dihe-in -80.94, 64.03 APE8-rot-na 32.82 APE67-dihe-in -75.31, -4.79 -52.17, -43.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.411 APE9-dist-out 8.21 T790M,V948R None None XRAY 1.83 0.185 0.218 A 331 296 12 0 0 12 [[712, 970]] 1.0 7jxq TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXQC 700 1007 1210.0 VNS:1102,ANP:1103 Type3,ATPlike Inactive DFGin 4.785 14.453 BLBplus -135.56, 173.47 59.34, 36.33 -94.04, 161.61 52.57, 85.94 80.36, 16.26 out-out out 13.527 Saltbr-out 12.033 HRD-in -65.88, -57.49 78.82, -12.32 out-out-none SNCoon out-none ActLoopNT-out 8.819 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.15 APE8-dihe-in -80.46, 67.52 APE8-rot-na 31.26 APE67-dihe-in -73.66, -6.11 -51.25, -43.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.434 T790M,V948R None None XRAY 1.83 0.185 0.218 C 331 298 10 0 0 10 [[712, 970]] 1.0 7jxq TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6XL4B 700 1007 1210.0 NQ1:1201,Q6K:1202 Type3,Type1 Inactive DFGin 4.808 14.497 BLBplus -133.43, 176.08 66.75, 17.79 -78.7, 146.83 53.41, 93.69 78.85, 14.72 out-out out 13.809 Saltbr-out 14.224 HRD-in -71.6, -57.82 77.95, -5.56 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.66 APE8-dihe-in -77.94, 72.67 APE8-rot-na 31.42 APE67-dihe-in -72.46, -3.15 -55.35, -40.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.932 T790M,V948R None None XRAY 2.06 0.216 0.252 B 328 292 16 0 0 16 [[712, 970]] 1.0 6xl4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXPC 700 1007 1210.0 JBJ:1101,YY3:1102 Type3,Type1 Inactive DFGin 4.791 14.489 BLBplus -135.14, 166.93 58.75, 39.54 -88.72, 165.62 50.16, 82.07 80.91, 11.4 out-out out 13.215 Saltbr-out 10.01 HRD-in -71.03, -65.61 90.59, -16.24 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.4 APE8-dihe-in -78.08, 71.31 APE8-rot-na 31.49 APE67-dihe-in -74.31, -4.1 -55.2, -45.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.734 T790M,V948R None None XRAY 2.16 0.214 0.247 C 331 292 16 0 0 16 [[712, 970]] 1.0 7jxp TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXPE 700 1007 1210.0 JBJ:1101,YY3:1102 Type3,Type1 Inactive DFGin 5.017 14.71 BLBplus -135.91, 163.38 57.21, 38.2 -87.34, 167.11 54.31, 95.16 79.16, 16.43 out-out out 13.581 Saltbr-out 11.008 HRD-in -68.91, -62.25 86.58, -12.8 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.81 APE8-dihe-in -81.71, 69.65 APE8-rot-na 31.8 APE67-dihe-in -77.02, -5.14 -52.47, -41.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.46 T790M,V948R None None XRAY 2.16 0.214 0.247 E 331 287 16 0 0 16 [[712, 970]] 1.0 7jxp TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7LG8A 702 1006 1210.0 VNS:1101,8RC:1102 Type3,Type1 Inactive DFGin 4.633 14.844 BLBplus -140.27, 173.45 52.29, 60.01 -103.04, 154.16 45.73, 86.09 71.19, 28.15 out-out out 14.014 Saltbr-out 11.713 HRD-in -68.53, -55.23 80.07, -8.53 out-out-out SNCooo out-out ActLoopNT-out 9.249 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.7 APE8-dihe-in -73.13, 67.89 APE8-rot-na 28.49 APE67-dihe-in -77.47, -4.15 -60.09, -40.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.274 T790M,V948R None None XRAY 2.93 0.237 0.27 A 331 280 15 0 0 15 [[712, 970]] 1.0 7lg8 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7LG8C 703 1004 1210.0 VNS:1101,8RC:1102 Type3,Type1 Inactive DFGin 4.832 14.737 BLBplus -140.02, 171.29 50.44, 57.58 -106.29, 155.85 48.29, 87.01 71.42, 29.21 out-out out 13.235 Saltbr-out 10.883 HRD-in -68.15, -55.55 79.56, -8.95 out-out-out SNCooo out-out ActLoopNT-out 9.216 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.11 APE8-dihe-in -71.99, 68.12 APE8-rot-na 28.1 APE67-dihe-in -76.72, -3.4 -59.75, -39.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.305 T790M,V948R None None XRAY 2.93 0.237 0.27 C 331 274 15 0 0 15 [[712, 970]] 1.0 7lg8 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7LG8D 702 1003 1210.0 VNS:1101,8RC:1102 Type3,Type1 Inactive DFGin 4.926 15.183 BLBplus -140.41, 172.1 51.47, 58.23 -106.49, 156.3 49.03, 86.93 72.22, 33.01 out-out out 13.784 Saltbr-out 11.231 HRD-in -67.28, -53.4 81.73, -11.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.55 APE8-dihe-in -71.42, 69.12 APE8-rot-na 28.09 APE67-dihe-in -78.92, -4.05 -59.63, -41.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.446 T790M,V948R None None XRAY 2.93 0.237 0.27 D 331 271 17 0 0 17 [[712, 970]] 1.0 7lg8 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7A2AA 700 984 1210.0 57N:1101,7G9:1102 Type3,Type1 Inactive DFGin 4.79 14.981 BLBplus -131.59, 170.62 61.54, 34.7 -80.75, 149.06 48.24, 92.48 77.59, 7.85 out-out out 13.521 Saltbr-out 11.363 HRD-in -68.93, -60.4 81.46, -8.87 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.16 APE8-dihe-in -83.82, 69.63 APE8-rot-na 32.14 APE67-dihe-in -69.62, -9.49 -57.3, -43.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.02 T790M,V948R None None XRAY 1.9 0.195 0.217 A 333 266 19 0 0 17 [[712, 970]] 1.0 7a2a TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7A2AB 699 984 1210.0 57N:1101,7G9:1102 Type3,Type1 Inactive DFGin 5.429 14.754 BLBplus -131.31, 171.38 59.7, 35.33 -84.58, 153.3 50.04, 92.4 77.68, 999.0 out-out out 13.16 Saltbr-out 10.438 HRD-in -66.1, -59.16 82.47, -6.26 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.47 APE8-dihe-in -82.95, 68.33 APE8-rot-na 32.13 APE67-dihe-in -69.29, -8.38 -57.66, -41.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.16 T790M,V948R None None XRAY 1.9 0.195 0.217 B 333 268 18 0 0 18 [[712, 970]] 1.0 7a2a TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7K1HA 701 1007 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 4.897 14.502 BLBplus -130.97, 170.62 58.17, 48.68 -100.05, 161.6 49.16, 78.42 69.2, 1.23 out-out out 13.749 Saltbr-out 11.264 HRD-in -77.07, -52.87 73.56, -9.67 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.57 APE8-dihe-in -79.59, 69.97 APE8-rot-na 32.69 APE67-dihe-in -73.02, -4.47 -58.4, -43.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.87 L858R,V948R None None XRAY 2.602 0.233 0.275 A 331 291 16 0 0 16 [[712, 970]] 1.0 7k1h TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7K1HB 701 1008 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 5.245 14.539 BLBplus -131.19, 172.0 58.43, 45.25 -101.59, 170.23 51.81, 92.29 77.64, 116.53 out-out out 13.419 Saltbr-out 9.137 HRD-in -79.53, -53.07 76.7, -9.03 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.65 APE8-dihe-in -81.29, 70.54 APE8-rot-na 31.4 APE67-dihe-in -72.0, -4.51 -57.97, -43.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.952 L858R,V948R None None XRAY 2.602 0.233 0.275 B 331 291 17 0 0 17 [[712, 970]] 1.0 7k1h TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7K1HC 701 1007 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 4.744 14.74 BLBplus -129.93, 170.49 56.69, 44.1 -96.18, 166.59 55.18, 77.55 73.78, 46.77 out-out out 13.454 Saltbr-out 8.834 HRD-in -79.27, -50.75 74.55, -8.77 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.24 APE8-dihe-in -82.15, 68.56 APE8-rot-na 31.93 APE67-dihe-in -74.95, -6.33 -58.99, -43.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.006 L858R,V948R None None XRAY 2.602 0.233 0.275 C 331 290 17 0 0 17 [[712, 970]] 1.0 7k1h TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7K1HD 701 1007 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 5.019 14.819 BLBplus -131.91, 172.88 57.19, 43.91 -99.27, 163.9 51.77, 84.58 74.04, -2.08 out-out out 13.649 Saltbr-out 10.156 HRD-in -78.62, -53.76 74.56, -9.86 out-out-out SNCooo out-out ActLoopNT-out 9.68 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.98 APE8-dihe-in -78.93, 62.04 APE8-rot-na 29.95 APE67-dihe-in -73.79, -3.52 -56.56, -42.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.07 L858R,V948R None None XRAY 2.602 0.233 0.275 D 331 292 15 0 0 15 [[712, 970]] 1.0 7k1h TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7K1HE 703 1007 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 5.157 14.635 BLBplus -131.84, 173.0 58.55, 47.55 -102.27, 167.87 51.85, 86.34 79.14, -85.43 out-out out 13.629 Saltbr-out 10.317 HRD-in -78.55, -50.1 74.47, -8.94 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.83 APE8-dihe-in -83.11, 68.71 APE8-rot-na 30.98 APE67-dihe-in -72.18, -4.84 -60.68, -43.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.99 L858R,V948R None None XRAY 2.602 0.233 0.275 E 331 289 16 0 0 16 [[712, 970]] 1.0 7k1h TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7K1HF 701 1007 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 4.905 14.421 BLBplus -132.01, 174.64 57.0, 46.09 -100.49, 170.69 50.88, 85.85 82.59, -107.03 out-out out 13.717 Saltbr-out 10.964 HRD-in -78.66, -52.82 76.59, -9.2 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.26 APE8-dihe-in -81.53, 68.79 APE8-rot-na 32.04 APE67-dihe-in -72.57, -5.45 -59.56, -43.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.067 L858R,V948R None None XRAY 2.602 0.233 0.275 F 331 290 17 0 0 17 [[712, 970]] 1.0 7k1h TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6P1DA 700 1021 1210.0 ANP:1101 ATPlike Inactive DFGin 5.301 16.437 BLBtrans -129.26, 172.58 65.52, 23.29 -64.33, 142.93 151.16, 79.23 78.73, -15.31 out-out out 13.52 Saltbr-out 12.421 HRD-in -76.98, -57.73 83.77, -12.82 out-out-none SNCoon out-none ActLoopNT-out 7.141 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 149.92 APE9-dihe-in -115.71, 137.77 APE8-dihe-in -79.58, 71.21 APE8-rot-na 32.94 APE67-dihe-in -73.74, -5.13 -51.22, -45.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.184 APE9-dist-in 7.677 None None None XRAY 2.4 0.195 0.213 A 327 309 13 0 0 13 [[712, 970]] 1.0 6p1d TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6WAKB 701 1020 1210.0 ANP:1101 ATPlike Inactive DFGin 5.177 16.231 BLBtrans -117.23, 173.55 69.28, 15.65 -59.01, 135.6 148.98, 94.52 90.59, -20.79 out-out out 13.949 Saltbr-out 13.543 HRD-in -74.15, -58.44 85.37, -10.97 out-out-none SNCoon out-none ActLoopNT-out 6.481 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -3.86 APE9-dihe-in -108.7, 124.16 APE8-dihe-in -81.26, 64.66 APE8-rot-na 31.83 APE67-dihe-in -71.85, -2.7 -48.1, -51.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.366 APE9-dist-in 7.826 T790M,V948R None None XRAY 2.4 0.219 0.23 B 328 316 4 0 0 4 [[712, 970]] 1.0 6wak TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6WXNB 701 1021 1210.0 ANP:1101 ATPlike Inactive DFGin 5.283 16.295 BLBtrans -123.51, 174.07 66.96, 19.19 -61.23, 137.15 158.07, 75.44 91.96, -18.66 out-out out 13.565 Saltbr-out 13.523 HRD-in -75.09, -55.39 80.46, -8.33 out-out-none SNCoon out-none ActLoopNT-out 6.48 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -21.86 APE9-dihe-in -115.99, 110.82 APE8-dihe-in -78.55, 77.75 APE8-rot-na 31.2 APE67-dihe-in -73.85, -5.28 -56.42, -42.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.825 APE9-dist-in 7.844 T790M,V948R None None XRAY 1.76 0.209 0.235 B 328 303 11 0 0 11 [[712, 970]] 1.0 6wxn TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8FV3B 701 1021 1210.0 ANP:1102 ATPlike Inactive DFGin 5.439 16.496 BLBtrans -118.64, 177.37 63.4, 20.55 -58.75, 145.81 159.38, 77.34 77.7, -11.94 out-out out 13.907 Saltbr-out 12.609 HRD-in -79.27, -57.12 85.07, -16.18 out-out-none SNCoon out-none ActLoopNT-out 6.551 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -85.47 APE9-dihe-in -94.5, 111.51 APE8-dihe-in -78.45, 79.51 APE8-rot-na 26.67 APE67-dihe-in -72.96, -7.53 -57.83, -45.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.158 APE9-dist-in 7.609 T790M,V948R None None XRAY 2.1 0.191 0.226 B 328 307 12 0 0 12 [[712, 970]] 1.0 8fv3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8FV3D 701 1008 1210.0 ANP:1102 ATPlike Inactive DFGin 5.123 16.069 BLBtrans -118.91, 178.66 63.22, 20.1 -58.76, 136.59 151.59, 72.8 86.53, -14.56 out-out out 13.636 Saltbr-out 11.878 HRD-in -77.73, -54.76 83.51, -15.49 out-out-none SNCoon out-none ActLoopNT-out 6.686 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -35.35 APE9-dihe-in -75.26, 139.37 APE8-dihe-in -77.41, 75.08 APE8-rot-na 30.35 APE67-dihe-in -77.52, -1.37 -56.44, -41.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.989 APE9-dist-in 7.856 T790M,V948R None None XRAY 2.1 0.191 0.226 D 328 295 13 0 0 12 [[712, 970]] 1.0 8fv3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8FV4A 701 1013 1210.0 ANP:1102 ATPlike Inactive DFGin 5.115 16.083 BLBtrans -131.04, 178.71 63.39, 21.89 -65.77, 133.12 153.56, 67.25 81.77, -5.74 out-out out 13.965 Saltbr-out 14.366 HRD-in -75.29, -65.35 93.54, -10.41 out-out-out SNCooo out-out ActLoopNT-out 6.614 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.22 APE8-dihe-in -79.99, 70.44 APE8-rot-na 34.65 APE67-dihe-in -69.8, 5.09 -60.12, -39.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.027 T790M,V948R None None XRAY 2.2 0.204 0.261 A 328 298 15 0 0 13 [[712, 970]] 1.0 8fv4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8TO3C 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 5.753 16.533 BLBtrans -133.38, -174.65 59.98, 24.74 -65.74, 136.64 157.32, 80.88 79.44, -13.7 out-out out 13.655 Saltbr-out 13.531 HRD-in -66.43, -56.05 80.37, -11.56 out-out-out SNCooo out-out ActLoopNT-out 6.373 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.97 APE8-dihe-in -84.11, 59.51 APE8-rot-na 29.31 APE67-dihe-in -74.18, -0.3 -51.78, -42.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.174 T790M,V948R None None XRAY 2.49 0.231 0.269 C 328 295 16 0 0 13 [[712, 970]] 1.0 8to3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8TO3D 702 1008 1210.0 ANP:1102 ATPlike Inactive DFGin 6.266 16.712 BLBtrans -127.69, 172.31 68.6, 30.15 -69.25, 140.14 165.75, 69.84 67.25, -4.22 out-out out 14.386 Saltbr-out 13.199 HRD-in -68.61, -53.44 82.24, -15.94 out-out-out SNCooo out-out ActLoopNT-out 6.552 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.24 APE8-dihe-in -79.84, 75.73 APE8-rot-na 31.27 APE67-dihe-in -78.58, -0.75 -60.94, -39.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.144 T790M,V948R None None XRAY 2.49 0.231 0.269 D 328 293 14 0 0 13 [[712, 970]] 1.0 8to3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8TO4A 701 1021 1210.0 ANP:1102 ATPlike Inactive DFGin 5.629 16.547 BLBtrans -124.14, -173.94 46.92, 31.67 -57.81, 155.21 158.64, 67.25 48.87, 11.58 out-out out 13.96 Saltbr-out 13.561 HRD-in -72.61, -58.43 93.96, -37.09 out-out-none SNCoon out-none ActLoopNT-out 6.932 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 82.65 APE8-dihe-in -66.65, 104.87 APE8-rot-na 26.84 APE67-dihe-in -69.56, -10.93 -75.01, -49.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.724 T790M,V948R None None XRAY 2.99 0.176 0.231 A 328 300 16 0 0 13 [[712, 970]] 1.0 8to4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4ZSEA 699 1007 1210.0 ANP:1101 ATPlike Inactive DFGin 5.335 16.18 BLBtrans -132.89, 171.35 59.18, 30.95 -64.3, 136.47 153.66, 69.99 84.54, -7.18 out-out out 13.41 Saltbr-out 12.542 HRD-in -69.44, -53.13 80.36, -12.32 out-out-none SNCoon out-none ActLoopNT-out 6.5 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 151.84 APE9-dihe-in -73.75, 154.61 APE8-dihe-in -84.04, 78.01 APE8-rot-na 31.44 APE67-dihe-in -73.82, -9.83 -53.67, -42.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.754 APE9-dist-in 7.631 T790M,V948R None None XRAY 1.97 0.191 0.213 A 331 297 12 0 0 12 [[712, 970]] 1.0 4zse TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4ZSEB 698 1022 1210.0 ANP:2001 ATPlike Inactive DFGin 5.443 16.534 BLBtrans -132.18, 168.84 69.74, 21.23 -63.33, 134.02 158.02, 77.95 88.87, -12.59 out-out out 13.594 Saltbr-out 12.729 HRD-in -70.54, -56.98 84.69, -9.62 out-out-none SNCoon out-none ActLoopNT-out 6.279 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -169.23 APE9-dihe-in -113.21, 138.46 APE8-dihe-in -83.6, 77.16 APE8-rot-na 29.29 APE67-dihe-in -64.08, -26.4 -59.09, -39.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.095 APE9-dist-in 7.664 T790M,V948R None None XRAY 1.97 0.191 0.213 B 331 313 12 0 0 12 [[712, 970]] 1.0 4zse TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4ZSEC 700 1013 1210.0 ANP:3001 ATPlike Inactive DFGin 5.527 16.551 BLBtrans -132.06, 169.7 72.1, 15.79 -57.63, 131.91 161.52, 79.23 90.56, -14.81 out-out out 13.464 Saltbr-out 12.84 HRD-in -70.03, -52.52 81.38, -14.98 out-out-none SNCoon out-none ActLoopNT-out 6.218 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.83 APE8-dihe-in -83.98, 70.07 APE8-rot-na 31.43 APE67-dihe-in -69.54, -11.42 -60.89, -38.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.916 T790M,V948R None None XRAY 1.97 0.191 0.213 C 331 301 13 0 0 13 [[712, 970]] 1.0 4zse TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXMA 700 1007 1210.0 ANP:1101 ATPlike Inactive DFGin 4.958 16.172 BLBtrans -132.35, 172.29 62.1, 35.15 -75.21, 146.26 142.71, 77.54 74.06, -11.26 out-out out 13.894 Saltbr-out 13.34 HRD-in -71.64, -59.02 81.62, -5.92 out-out-none SNCoon out-none ActLoopNT-out 8.072 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.88 APE8-dihe-in -79.6, 70.11 APE8-rot-na 34.33 APE67-dihe-in -76.06, -4.61 -47.57, -45.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.53 T790M,V948R None None XRAY 2.192 0.228 0.271 A 331 287 18 0 0 14 [[712, 970]] 1.0 7jxm TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8PO4B 700 1014 1210.0 ATP:1101 ATPlike Inactive DFGin 5.624 16.394 BLBtrans -121.3, 175.63 63.19, 26.9 -63.92, 138.21 163.94, 68.04 83.38, -10.03 out-out out 13.6 Saltbr-out 13.029 HRD-in -73.28, -55.5 80.32, -14.85 out-out-out SNCooo out-out ActLoopNT-out 6.486 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.23 APE8-dihe-in -81.98, 63.66 APE8-rot-na 32.98 APE67-dihe-in -71.84, -8.05 -50.66, -40.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.255 V948R None None XRAY 1.621 0.211 0.243 B 328 295 20 0 0 13 [[712, 970]] 1.0 8po4 TYR_EGFR_HUMAN TYR 7.9e-88 300.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2GS7A 703 1012 1210.0 ANP:60301 ATPlike Inactive DFGin 5.373 16.634 BLBtrans -99.51, 171.1 60.81, 33.31 -69.51, 142.46 163.35, 73.66 92.75, -41.51 out-out out 14.089 Saltbr-out 13.075 HRD-in -69.91, -45.27 73.69, -18.97 out-out-out SNCooo out-out ActLoopNT-out 6.362 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 134.47 APE9-dihe-in -142.48, 136.32 APE8-dihe-in -67.69, 63.71 APE8-rot-na 37.05 APE67-dihe-in -69.28, 11.68 -49.57, -49.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.012 APE9-dist-out 8.2 V948R None None XRAY 2.6 0.258 0.298 A 330 281 4 0 0 4 [[712, 970]] 1.0 2gs7 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2GS7B 701 1016 1210.0 ANP:60302 ATPlike Inactive DFGin 5.284 16.349 BLBtrans -104.25, 165.26 71.85, 26.96 -61.96, 139.7 163.92, 72.26 85.01, -32.88 out-out out 13.995 Saltbr-out 14.309 HRD-in -67.25, -42.1 68.95, -3.07 out-out-none SNCoon out-none ActLoopNT-out 6.473 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 151.84 APE9-dihe-in -148.05, 134.8 APE8-dihe-in -62.95, 72.83 APE8-rot-na 33.79 APE67-dihe-in -67.93, 1.22 -55.72, -45.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.13 APE9-dist-in 7.902 V948R None None XRAY 2.6 0.258 0.298 B 330 288 3 0 0 3 [[712, 970]] 1.0 2gs7 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3GT8A 700 1014 1210.0 ANP:60002 ATPlike Inactive DFGin 4.993 16.39 BLBtrans -126.87, 160.91 79.29, 15.25 -62.33, 143.15 149.45, 88.24 77.42, 3.92 out-out out 14.088 Saltbr-out 14.957 HRD-in -72.04, -61.33 88.51, -0.69 out-out-none SNCoon out-none ActLoopNT-out 6.56 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 19.46 APE8-rot-na 342.23 APE67-dihe-in -68.79, -19.52 -40.63, -50.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V948R None None XRAY 2.955 0.219 0.275 A 330 300 15 0 0 15 [[712, 970]] 1.0 3gt8 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3GT8B 701 1007 1210.0 ANP:60001 ATPlike Inactive DFGin 5.247 16.102 BLBtrans -113.7, -174.86 52.25, 31.77 -67.43, 143.58 157.41, 75.54 60.22, 2.12 out-out out 13.355 Saltbr-out 13.716 HRD-in -65.21, -59.58 85.13, -27.25 out-out-none SNCoon out-none ActLoopNT-out 6.384 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 3.18 APE8-rot-na 352.22 APE67-dihe-in -64.44, -9.93 -42.76, -50.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V948R None None XRAY 2.955 0.219 0.275 B 330 292 15 0 0 15 [[712, 970]] 1.0 3gt8 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3GT8C 699 1007 1210.0 ANP:60003 ATPlike Inactive DFGin 4.731 16.042 BLBtrans -111.03, -172.93 50.46, 27.13 -68.53, 136.25 146.08, 72.89 59.13, 17.74 out-out out 14.315 Saltbr-out 13.283 HRD-in -57.94, -53.03 83.1, -30.64 out-out-none SNCoon out-none ActLoopNT-out 6.516 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.04 APE8-dihe-in -73.71, 55.48 APE8-rot-na 345.44 APE67-dihe-in -72.77, 4.68 -41.49, -48.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.982 V948R None None XRAY 2.955 0.219 0.275 C 330 296 13 0 0 13 [[712, 970]] 1.0 3gt8 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3GT8D 701 1010 1210.0 ANP:60004 ATPlike Inactive DFGin 5.236 16.347 BLBtrans -129.98, 167.43 62.52, 32.14 -70.14, 140.82 152.86, 71.47 77.5, -20.57 out-out out 14.059 Saltbr-out 13.514 HRD-in -61.66, -53.51 87.8, -16.84 out-out-none SNCoon out-none ActLoopNT-out 6.797 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 30.46 APE8-rot-na 344.36 APE67-dihe-in -63.75, 2.23 -59.31, -42.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V948R None None XRAY 2.955 0.219 0.275 D 330 295 15 0 0 15 [[712, 970]] 1.0 3gt8 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5CNOA 700 1015 1210.0 ANP:61001 ATPlike Inactive DFGin 5.504 16.161 BLBtrans -118.04, 171.2 68.22, 21.52 -56.79, 132.54 171.14, 68.18 99.53, -19.86 out-out out 13.718 Saltbr-out 12.944 HRD-in -82.44, -48.26 77.49, -9.43 out-out-out SNCooo out-out ActLoopNT-out 6.341 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 122.24 APE9-dihe-in -77.97, 140.5 APE8-dihe-in -80.47, 64.47 APE8-rot-na 27.48 APE67-dihe-in -78.06, -5.87 -50.51, -36.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.588 APE9-dist-out 8.271 V948R None None XRAY 1.55 0.176 0.203 A 330 300 16 0 0 11 [[712, 970]] 1.0 5cno TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5CNNB 700 1014 1210.0 ANP:61101 ATPlike Inactive DFGin 5.571 16.39 BLBtrans -117.7, 174.34 67.16, 24.17 -60.91, 135.45 168.23, 72.49 97.23, -21.68 out-out out 13.788 Saltbr-out 12.759 HRD-in -80.25, -51.08 77.81, -11.48 out-out-out SNCooo out-out ActLoopNT-out 6.374 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -75.45 APE9-dihe-in -63.67, 125.67 APE8-dihe-in -78.86, 65.92 APE8-rot-na 30.44 APE67-dihe-in -73.57, -5.24 -51.98, -40.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.086 APE9-dist-out 8.279 I706Q None None XRAY 1.9 0.183 0.211 B 350 304 11 0 0 11 [[712, 970]] 1.0 5cnn TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6XL4C 700 1011 1210.0 No_ligand No_ligand Inactive DFGin 5.173 16.517 BLBtrans -130.53, 179.54 70.03, 18.19 -70.23, 136.56 157.75, 76.14 77.79, 0.31 out-out out 14.194 Saltbr-out 13.111 HRD-in -72.76, -55.65 79.71, -6.02 out-out-none SNCoon out-none ActLoopNT-out 8.397 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -34.91 APE9-dihe-in -105.63, 136.03 APE8-dihe-in -73.26, 62.83 APE8-rot-na 34.69 APE67-dihe-in -76.36, -0.13 -55.59, -42.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.725 APE9-dist-in 7.853 T790M,V948R None None XRAY 2.06 0.216 0.252 C 328 302 10 0 0 7 [[712, 970]] 1.0 6xl4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7UKWD 702 1012 1210.0 No_ligand No_ligand Inactive DFGin 5.111 16.402 BLBtrans -118.29, 176.11 63.98, 19.5 -58.45, 142.23 151.96, 85.11 74.09, -5.14 out-out out 14.506 Saltbr-out 14.168 HRD-in -78.92, -49.36 80.69, -15.83 out-out-none SNCoon out-none ActLoopNT-out 6.874 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -7.72 APE9-dihe-in -116.7, 121.41 APE8-dihe-in -78.74, 61.73 APE8-rot-na 35.22 APE67-dihe-in -71.17, 12.82 -43.8, -49.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.193 APE9-dist-in 7.4 T790M,V948R None None XRAY 2.6 0.198 0.25 D 328 300 6 0 0 6 [[712, 970]] 1.0 7ukw TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8FV4B 702 1007 1210.0 No_ligand No_ligand Inactive DFGin 5.127 16.362 BLBtrans -126.57, 176.61 61.99, 14.29 -48.04, 140.93 155.83, 88.84 81.69, -24.77 out-out out 14.377 Saltbr-out 14.483 HRD-in -71.39, -59.22 91.02, -25.25 out-out-none SNCoon out-none ActLoopNT-out 6.657 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 172.6 APE9-dihe-in -105.91, 119.23 APE8-dihe-in -74.97, 58.92 APE8-rot-na 28.96 APE67-dihe-in -73.69, -0.36 -43.23, -49.45 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.935 APE9-dist-in 7.668 T790M,V948R None None XRAY 2.2 0.204 0.261 B 328 303 3 0 0 3 [[712, 970]] 1.0 8fv4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2RFDA 703 1018 1210.0 No_ligand No_ligand Inactive DFGin 5.168 16.624 BLBtrans -126.59, 163.05 65.13, 46.33 -86.2, 138.52 145.4, 72.73 74.27, 0.85 out-out out 13.925 Saltbr-out 13.75 HRD-in -82.95, -54.79 88.4, -38.78 out-out-out SNCooo out-out ActLoopNT-out 6.675 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 120.67 APE9-dihe-in -92.29, 144.14 APE8-dihe-in -73.56, 103.24 APE8-rot-na 34.0 APE67-dihe-in -60.74, -31.07 -81.4, -44.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.277 APE9-dist-out 8.309 K823E None None XRAY 3.6 0.234 0.278 A 324 288 14 0 0 11 [[712, 970]] 1.0 2rfd TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2RFDB 703 1018 1210.0 No_ligand No_ligand Inactive DFGin 4.798 16.048 BLBtrans -162.64, 174.09 64.27, 34.61 -66.47, 135.79 150.17, 58.46 39.76, 39.55 out-out out 14.551 Saltbr-out 14.591 HRD-in -87.58, -38.54 73.26, -40.51 out-out-out SNCooo out-out ActLoopNT-out 6.981 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -158.86, 162.54 APE9-dihe-in -151.43, 143.75 APE8-dihe-in -75.49, 85.44 APE8-rot-na 33.26 APE67-dihe-in -61.06, -19.22 -61.41, -32.59 APE12-dist-na 999.0 APE11-dist-na 14.137 APE10-dist-na 13.735 APE9-dist-out 8.341 K823E None None XRAY 3.6 0.234 0.278 B 324 286 12 0 0 8 [[712, 970]] 1.0 2rfd TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2RFEA 702 1002 1210.0 No_ligand No_ligand Inactive DFGin 5.617 17.059 BLBtrans -126.07, 179.87 68.39, 3.88 -53.1, 130.92 165.63, 74.56 83.11, -16.61 out-out out 14.074 Saltbr-out 13.9 HRD-in -68.19, -58.25 85.2, -7.35 out-out-out SNCooo out-out ActLoopNT-out 7.529 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 169.37 APE9-dihe-in -153.82, 129.38 APE8-dihe-in -69.69, 55.01 APE8-rot-na 36.27 APE67-dihe-in -68.46, -8.85 -37.09, -46.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.019 APE9-dist-out 8.208 K823E None None XRAY 2.9 0.229 0.271 A 324 285 8 0 0 8 [[712, 970]] 1.0 2rfe TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2RFEB 703 1012 1210.0 No_ligand No_ligand Inactive DFGin 5.547 16.821 BLBtrans -132.21, -179.96 69.1, 4.87 -54.39, 127.17 163.8, 72.34 86.16, -10.85 out-out out 14.149 Saltbr-out 13.706 HRD-in -70.46, -55.75 83.73, -11.44 out-out-out SNCooo out-out ActLoopNT-out 8.117 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 130.21 APE9-dihe-in -143.12, 137.45 APE8-dihe-in -71.16, 61.18 APE8-rot-na 39.12 APE67-dihe-in -74.49, -2.04 -48.16, -41.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.114 APE9-dist-out 8.386 K823E None None XRAY 2.9 0.229 0.271 B 324 273 11 0 0 11 [[712, 970]] 1.0 2rfe TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2RFEC 702 983 1210.0 No_ligand No_ligand Inactive DFGin 5.429 16.838 BLBtrans -130.03, -176.46 64.15, 8.93 -57.23, 123.22 161.3, 70.99 105.16, -30.21 out-out out 13.896 Saltbr-out 13.655 HRD-in -74.31, -52.17 78.67, -3.86 out-out-out SNCooo out-out ActLoopNT-out 7.269 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 144.94 APE9-dihe-in -133.96, 136.3 APE8-dihe-in -70.77, 58.99 APE8-rot-na 32.18 APE67-dihe-in -75.34, 9.03 -46.34, -40.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.603 APE9-dist-out 8.072 K823E None None XRAY 2.9 0.229 0.271 C 324 262 20 0 0 11 [[712, 970]] 1.0 2rfe TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2RFED 703 1018 1210.0 No_ligand No_ligand Inactive DFGin 5.25 16.653 BLBtrans -125.7, 174.95 73.25, 5.66 -51.33, 131.77 165.42, 64.15 87.01, -8.38 out-out out 14.409 Saltbr-out 13.43 HRD-in -76.96, -58.59 84.17, -6.71 out-out-out SNCooo out-out ActLoopNT-out 7.326 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 131.37 APE9-dihe-in -130.04, 137.41 APE8-dihe-in -68.34, 54.24 APE8-rot-na 34.22 APE67-dihe-in -67.2, -1.76 -41.17, -50.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.21 APE9-dist-out 8.062 K823E None None XRAY 2.9 0.229 0.271 D 324 278 14 0 0 11 [[712, 970]] 1.0 2rfe TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V66A 701 1014 1210.0 QP1:1202 Type1 Inactive DFGin 5.426 16.514 BLBtrans -124.42, 177.95 61.86, 22.75 -59.98, 134.04 162.48, 75.29 88.51, -14.09 out-out out 14.22 Saltbr-out 14.194 HRD-in -77.47, -52.32 80.43, -9.63 out-out-out SNCooo out-out ActLoopNT-out 6.728 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.38, -13.47 APE9-dihe-in -92.56, 110.16 APE8-dihe-in -84.07, 69.49 APE8-rot-na 34.36 APE67-dihe-in -75.03, -2.7 -49.4, -44.98 APE12-dist-na 15.483 APE11-dist-na 13.333 APE10-dist-na 9.108 APE9-dist-in 7.409 T790M,V948R None None XRAY 1.79 0.187 0.226 A 327 314 0 0 0 0 [[712, 970]] 1.0 6v66 TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V66B 701 1014 1210.0 QP1:1202 Type1 Inactive DFGin 5.419 16.392 BLBtrans -126.49, 176.29 67.7, 20.21 -61.15, 136.48 152.37, 70.68 83.55, -13.04 out-out out 13.94 Saltbr-out 13.622 HRD-in -79.19, -50.94 79.82, -14.47 out-out-out SNCooo out-out ActLoopNT-out 6.943 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 5.96 APE9-dihe-in -124.61, 120.95 APE8-dihe-in -80.22, 74.26 APE8-rot-na 32.87 APE67-dihe-in -76.34, -6.09 -59.72, -39.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.496 APE9-dist-out 8.123 T790M,V948R None None XRAY 1.79 0.187 0.226 B 327 302 12 0 0 12 [[712, 970]] 1.0 6v66 TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V66C 701 1012 1210.0 QP1:1101 Type1 Inactive DFGin 5.717 16.359 BLBtrans -124.4, -178.87 63.87, 27.71 -73.72, 147.34 167.32, 74.76 78.96, -14.16 out-out out 13.351 Saltbr-out 12.617 HRD-in -80.32, -46.75 78.9, -11.66 out-out-none SNCoon out-none ActLoopNT-out 7.109 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.19 APE8-dihe-in -84.45, 72.53 APE8-rot-na 33.88 APE67-dihe-in -72.73, -2.16 -59.44, -40.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.949 T790M,V948R None None XRAY 1.79 0.187 0.226 C 327 299 13 0 0 13 [[712, 970]] 1.0 6v66 TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V6KB 700 1014 1210.0 QQJ:1202 Type1 Inactive DFGin 5.446 16.677 BLBtrans -120.08, 174.38 67.53, 23.96 -61.85, 141.71 152.32, 75.87 78.49, -9.92 out-out out 13.799 Saltbr-out 12.459 HRD-in -73.15, -55.56 80.97, -11.2 out-out-none SNCoon out-none ActLoopNT-out 6.793 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 70.83 APE8-rot-na 32.65 APE67-dihe-in -71.54, -3.4 -53.97, -47.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 2.2 0.215 0.239 B 327 301 14 0 0 14 [[712, 970]] 1.0 6v6k TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V6KE 701 1014 1210.0 QQJ:1202 Type1 Inactive DFGin 5.091 16.031 BLBtrans -122.64, 177.93 70.8, 11.32 -64.29, 136.62 145.68, 77.64 104.91, -23.54 out-out out 13.566 Saltbr-out 12.95 HRD-in -74.97, -57.13 87.56, -9.8 out-out-none SNCoon out-none ActLoopNT-out 6.785 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 103.34 APE8-dihe-in -72.02, 69.2 APE8-rot-na 28.12 APE67-dihe-in -72.14, 1.74 -55.9, -45.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.954 T790M,V948R None None XRAY 2.2 0.215 0.239 E 327 303 11 0 0 11 [[712, 970]] 1.0 6v6k TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V6KH 701 1014 1210.0 QQJ:1202 Type1 Inactive DFGin 5.38 16.617 BLBtrans -122.23, -176.76 60.52, 24.13 -72.16, 137.8 149.6, 82.13 84.24, -7.03 out-out out 14.463 Saltbr-out 16.568 HRD-in -71.15, -55.32 82.36, -11.57 out-out-out SNCooo out-out ActLoopNT-out 6.532 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -89.11, -2.11 APE9-dihe-in -99.5, 119.67 APE8-dihe-in -81.25, 72.47 APE8-rot-na 35.55 APE67-dihe-in -80.47, -1.73 -53.94, -37.54 APE12-dist-na 18.705 APE11-dist-na 16.028 APE10-dist-na 11.677 APE9-dist-out 8.114 T790M,V948R None None XRAY 2.2 0.215 0.239 H 327 314 0 0 0 0 [[712, 970]] 1.0 6v6k TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V6OA 701 1007 1210.0 QQM:1202 Type1 Inactive DFGin 5.298 16.727 BLBtrans -121.65, 172.71 69.64, 21.71 -62.97, 137.24 151.72, 75.2 80.63, -10.98 out-out out 14.391 Saltbr-out 13.42 HRD-in -75.85, -53.93 83.31, -13.79 out-out-out SNCooo out-out ActLoopNT-out 6.809 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.46, -8.8 APE9-dihe-in -105.55, 118.94 APE8-dihe-in -80.71, 68.41 APE8-rot-na 31.83 APE67-dihe-in -75.0, -4.07 -53.04, -43.94 APE12-dist-na 17.172 APE11-dist-na 14.893 APE10-dist-na 10.703 APE9-dist-in 7.811 T790M,V948R None None XRAY 2.1 0.196 0.221 A 327 307 0 0 0 0 [[712, 970]] 1.0 6v6o TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V6OB 701 1014 1210.0 QQM:1202 Type1 Inactive DFGin 5.753 16.86 BLBtrans -121.27, 172.7 70.02, 21.31 -63.98, 138.97 154.89, 75.61 80.68, -11.77 out-out out 14.192 Saltbr-out 13.383 HRD-in -75.47, -53.91 84.16, -12.57 out-out-out SNCooo out-out ActLoopNT-out 6.456 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -76.92, -9.63 APE9-dihe-in -88.61, 118.08 APE8-dihe-in -81.24, 68.33 APE8-rot-na 32.0 APE67-dihe-in -74.5, -4.48 -53.39, -42.67 APE12-dist-na 18.881 APE11-dist-na 15.887 APE10-dist-na 11.381 APE9-dist-out 8.301 T790M,V948R None None XRAY 2.1 0.196 0.221 B 327 314 0 0 0 0 [[712, 970]] 1.0 6v6o TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V6OF 701 1012 1210.0 QQM:1202 Type1 Inactive DFGin 5.905 17.242 BLBtrans -120.46, 172.23 70.73, 22.19 -64.5, 139.46 157.13, 75.08 81.89, -12.08 out-out out 13.742 Saltbr-out 12.61 HRD-in -74.49, -52.75 85.72, -15.71 out-out-none SNCoon out-none ActLoopNT-out 6.811 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.82 APE8-dihe-in -82.55, 69.28 APE8-rot-na 31.97 APE67-dihe-in -74.52, -5.14 -52.67, -43.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.827 T790M,V948R None None XRAY 2.1 0.196 0.221 F 327 299 13 0 0 13 [[712, 970]] 1.0 6v6o TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V6OG 701 1009 1210.0 QQM:1301 Type1 Inactive DFGin 5.55 16.214 BLBtrans -119.98, -175.83 64.58, 23.85 -74.9, 132.09 162.27, 73.99 101.97, 164.72 out-out out 13.363 Saltbr-out 11.572 HRD-in -77.28, -50.81 78.9, -9.78 out-out-none SNCoon out-none ActLoopNT-out 9.86 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.89 APE8-dihe-in -78.97, 76.25 APE8-rot-na 32.23 APE67-dihe-in -70.7, -0.71 -59.43, -44.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.947 T790M,V948R None None XRAY 2.1 0.196 0.221 G 327 294 15 0 0 15 [[712, 970]] 1.0 6v6o TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V5NB 700 1008 1210.0 QP7:1101 Type1 Inactive DFGin 5.528 16.668 BLBtrans -119.94, 178.74 66.11, 18.96 -52.29, 130.24 160.73, 59.1 85.08, -2.96 out-out out 14.066 Saltbr-out 12.919 HRD-in -79.78, -55.13 78.99, -6.78 out-out-none SNCoon out-none ActLoopNT-out 6.762 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 9.17 APE9-dihe-in -103.02, 125.51 APE8-dihe-in -71.63, 72.68 APE8-rot-na 25.68 APE67-dihe-in -77.13, 1.99 -54.76, -38.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.768 APE9-dist-in 7.861 T790M,V948R None None XRAY 2.4 0.194 0.243 B 328 297 12 0 0 12 [[712, 970]] 1.0 6v5n TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V5NC 701 1007 1210.0 QP7:1101 Type1 Inactive DFGin 6.173 17.209 BLBtrans -123.09, 177.25 64.84, 25.93 -67.2, 127.86 173.41, 73.29 98.01, -33.09 out-out out 13.843 Saltbr-out 12.806 HRD-in -77.86, -53.16 83.3, -4.81 out-out-out SNCooo out-out ActLoopNT-out 6.605 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.15 APE8-dihe-in -80.57, 70.35 APE8-rot-na 34.86 APE67-dihe-in -74.95, -1.76 -59.11, -43.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.194 T790M,V948R None None XRAY 2.4 0.194 0.243 C 328 294 13 0 0 13 [[712, 970]] 1.0 6v5n TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V5ND 701 1008 1210.0 QP7:1101 Type1 Inactive DFGin 5.464 16.875 BLBtrans -122.79, 173.83 67.54, 11.62 -44.12, 126.51 166.91, 74.2 86.38, -8.67 out-out out 14.234 Saltbr-out 13.559 HRD-in -79.51, -49.19 78.66, -5.24 out-out-out SNCooo out-out ActLoopNT-out 6.933 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -72.76, -24.22 APE9-dihe-in -89.09, 115.08 APE8-dihe-in -83.81, 64.66 APE8-rot-na 32.09 APE67-dihe-in -75.96, 5.83 -39.75, -53.8 APE12-dist-na 16.003 APE11-dist-na 13.192 APE10-dist-na 9.024 APE9-dist-in 7.333 T790M,V948R None None XRAY 2.4 0.194 0.243 D 328 308 0 0 0 0 [[712, 970]] 1.0 6v5n TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V5PB 701 1012 1210.0 QP4:1101 Type1 Inactive DFGin 5.303 16.35 BLBtrans -118.73, 170.65 71.18, 16.69 -51.79, 134.25 157.01, 66.81 84.4, -8.65 out-out out 13.951 Saltbr-out 13.315 HRD-in -75.9, -58.94 89.67, -12.03 out-out-out SNCooo out-out ActLoopNT-out 6.666 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.92 APE8-dihe-in -85.33, 67.36 APE8-rot-na 31.73 APE67-dihe-in -71.82, -2.95 -53.08, -40.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.089 T790M,V948R None None XRAY 2.3 0.18 0.194 B 328 299 13 0 0 13 [[712, 970]] 1.0 6v5p TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V5PC 701 1008 1210.0 QP4:1101 Type1 Inactive DFGin 5.83 16.755 BLBtrans -115.52, 179.63 64.16, 24.84 -64.39, 139.3 166.3, 74.9 85.47, -20.18 out-out out 13.606 Saltbr-out 13.882 HRD-in -73.77, -54.08 87.02, -8.4 out-out-none SNCoon out-none ActLoopNT-out 6.406 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.59 APE8-dihe-in -84.44, 72.48 APE8-rot-na 36.56 APE67-dihe-in -75.91, -4.6 -60.99, -34.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.988 T790M,V948R None None XRAY 2.3 0.18 0.194 C 328 295 13 0 0 13 [[712, 970]] 1.0 6v5p TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6V5PD 701 1008 1210.0 QP4:1101 Type1 Inactive DFGin 5.46 16.564 BLBtrans -120.28, 175.29 66.46, 14.28 -49.73, 134.24 162.88, 82.49 92.29, -24.11 out-out out 14.343 Saltbr-out 14.015 HRD-in -75.94, -55.12 90.57, -21.14 out-out-out SNCooo out-out ActLoopNT-out 6.809 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -65.99, -23.04 APE9-dihe-in -93.42, 113.55 APE8-dihe-in -81.58, 67.98 APE8-rot-na 34.43 APE67-dihe-in -70.62, -1.7 -51.12, -49.96 APE12-dist-na 15.187 APE11-dist-na 13.359 APE10-dist-na 9.332 APE9-dist-in 7.511 T790M,V948R None None XRAY 2.3 0.18 0.194 D 328 308 0 0 0 0 [[712, 970]] 1.0 6v5p TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7UKWB 702 1010 1210.0 ZRT:1101 Type1 Inactive DFGin 5.685 16.047 BLBtrans -113.97, -161.81 58.02, 23.78 -82.99, 120.69 174.98, 81.16 148.01, -65.31 out-out out 13.055 Saltbr-out 14.431 HRD-in -77.09, -41.34 72.52, -21.33 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.74 APE8-dihe-in -77.84, 69.21 APE8-rot-na 30.93 APE67-dihe-in -73.33, 2.8 -53.59, -40.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.885 T790M,V948R None None XRAY 2.6 0.198 0.25 B 328 292 17 0 0 17 [[712, 970]] 1.0 7ukw TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7UKWC 700 1005 1210.0 ZRT:1101 Type1 Inactive DFGin 4.989 15.935 BLBtrans -123.13, -177.75 72.13, 23.23 -82.62, 140.54 153.1, 70.99 83.68, 5.4 out-out out 13.458 Saltbr-out 14.542 HRD-in -89.97, -42.34 71.46, -11.24 out-out-none SNCoon out-none ActLoopNT-out 7.301 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 104.7 APE8-dihe-in -76.72, 75.0 APE8-rot-na 20.02 APE67-dihe-in -68.67, -13.51 -56.7, -40.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.852 T790M,V948R None None XRAY 2.6 0.198 0.25 C 328 287 19 0 0 13 [[712, 970]] 1.0 7ukw TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5X2AC 700 1015 1210.0 7XO:1104 Type1 Inactive DFGin 5.504 16.539 BLBtrans -121.56, -177.75 69.47, 12.59 -60.5, 141.21 167.5, 68.5 89.76, -35.23 out-out out 13.565 Saltbr-out 13.137 HRD-in -66.9, -48.76 80.92, -13.83 out-out-out SNCooo out-out ActLoopNT-out 7.021 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.32 APE8-dihe-in -80.48, 64.62 APE8-rot-na 38.22 APE67-dihe-in -72.09, -6.11 -53.33, -40.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.214 T790M,V948R None None XRAY 1.85 0.176 0.219 C 331 303 13 0 0 13 [[712, 970]] 1.0 5x2a TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5X2CA 700 1015 1210.0 7XR:1104 Type1 Inactive DFGin 5.521 16.244 BLBtrans -119.2, -173.9 68.01, 13.0 -61.53, 135.68 163.01, 80.32 88.29, -8.64 out-out out 13.736 Saltbr-out 12.844 HRD-in -81.15, -54.79 82.63, -11.78 out-out-out SNCooo out-out ActLoopNT-out 6.575 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 8.3 APE9-dihe-in -61.54, 131.22 APE8-dihe-in -85.76, 71.43 APE8-rot-na 36.24 APE67-dihe-in -67.14, -14.04 -60.63, -39.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.547 APE9-dist-out 8.325 T790M,V948R None None XRAY 2.05 0.175 0.202 A 331 304 12 0 0 12 [[712, 970]] 1.0 5x2c TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5X2CB 701 1014 1210.0 7XR:1108 Type1 Inactive DFGin 5.614 16.533 BLBtrans -123.4, -172.44 64.48, 17.44 -63.31, 135.2 170.91, 82.18 86.12, -10.39 out-out out 13.935 Saltbr-out 13.402 HRD-in -68.72, -52.33 82.34, -14.55 out-out-out SNCooo out-out ActLoopNT-out 6.813 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -134.03 APE9-dihe-in -64.14, 138.31 APE8-dihe-in -88.3, 72.92 APE8-rot-na 37.78 APE67-dihe-in -73.91, -8.47 -60.44, -40.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.552 APE9-dist-out 8.569 T790M,V948R None None XRAY 2.05 0.175 0.202 B 331 303 11 0 0 11 [[712, 970]] 1.0 5x2c TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5X2FA 700 1014 1210.0 7XU:3001 Type1 Inactive DFGin 5.277 16.448 BLBtrans -123.32, 172.02 76.25, 14.66 -63.1, 136.14 155.85, 76.2 93.55, -18.43 out-out out 13.903 Saltbr-out 13.521 HRD-in -64.37, -47.13 82.94, -11.58 out-out-out SNCooo out-out ActLoopNT-out 6.686 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -139.26 APE9-dihe-in -65.98, 137.84 APE8-dihe-in -86.71, 77.15 APE8-rot-na 28.13 APE67-dihe-in -65.36, -24.94 -60.66, -39.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.462 APE9-dist-out 8.371 T790M,V948R None None XRAY 2.2 0.204 0.24 A 331 301 12 0 0 12 [[712, 970]] 1.0 5x2f TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5X2FB 699 1010 1210.0 7XU:1101 Type1 Inactive DFGin 5.475 16.751 BLBtrans -127.63, 167.89 80.54, 16.33 -63.02, 131.83 161.78, 84.37 83.6, -4.7 out-out out 14.234 Saltbr-out 13.829 HRD-in -67.38, -48.36 82.16, -11.42 out-out-out SNCooo out-out ActLoopNT-out 6.717 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -58.77, -35.5 APE9-dihe-in -81.98, 121.93 APE8-dihe-in -88.82, 74.84 APE8-rot-na 21.79 APE67-dihe-in -65.18, -22.17 -60.37, -39.04 APE12-dist-na 16.028 APE11-dist-na 13.825 APE10-dist-na 9.783 APE9-dist-in 7.662 T790M,V948R None None XRAY 2.2 0.204 0.24 B 331 312 0 0 0 0 [[712, 970]] 1.0 5x2f TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5X2FC 700 1014 1210.0 7XU:1101 Type1 Inactive DFGin 5.528 16.589 BLBtrans -127.54, 178.33 71.1, 24.62 -67.94, 133.51 165.25, 78.29 84.95, -3.1 out-out out 13.776 Saltbr-out 13.057 HRD-in -67.71, -49.31 79.01, -3.44 out-out-none SNCoon out-none ActLoopNT-out 6.954 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 150.95 APE8-dihe-in -93.37, 90.33 APE8-rot-na 3.23 APE67-dihe-in -70.21, -14.78 -62.45, -39.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.638 T790M,V948R None None XRAY 2.2 0.204 0.24 C 331 302 13 0 0 13 [[712, 970]] 1.0 5x2f TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5X2FD 697 1014 1210.0 7XU:1101 Type1 Inactive DFGin 5.498 16.498 BLBtrans -130.98, 165.88 79.98, 18.78 -66.39, 133.64 153.14, 81.34 83.33, -4.64 out-out out 14.276 Saltbr-out 14.481 HRD-in -63.96, -47.23 82.78, -10.18 out-out-out SNCooo out-out ActLoopNT-out 6.486 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -35.63 APE9-dihe-in -100.74, 141.55 APE8-dihe-in -86.44, 64.59 APE8-rot-na 29.63 APE67-dihe-in -73.4, -13.47 -53.45, -43.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.743 APE9-dist-out 8.389 T790M,V948R None None XRAY 2.2 0.204 0.24 D 331 309 7 0 0 7 [[712, 970]] 1.0 5x2f TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXIA 700 1006 1210.0 8BS:1101 Type1 Inactive DFGin 6.002 16.539 BLBtrans -128.56, -179.35 55.18, 20.34 -72.14, 105.08 161.03, 82.24 -164.24, -136.24 out-out out 13.357 Saltbr-out 11.38 HRD-in -66.93, -56.02 77.07, -6.66 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.19 APE8-dihe-in -80.02, 70.1 APE8-rot-na 30.7 APE67-dihe-in -73.23, -5.24 -53.52, -45.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.479 T790M,V948R None None XRAY 3.0 0.278 0.312 A 331 290 17 0 0 17 [[712, 970]] 1.0 7jxi TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXID 702 1006 1210.0 8BS:1101 Type1 Inactive DFGin 5.407 16.257 BLBtrans -129.42, 179.04 50.18, 64.39 -110.41, 142.47 148.26, 80.05 85.73, -1.43 out-out out 13.403 Saltbr-out 12.596 HRD-in -71.0, -57.45 77.99, -6.63 out-out-none SNCoon out-none ActLoopNT-out 9.223 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.12 APE8-dihe-in -80.19, 70.22 APE8-rot-na 30.77 APE67-dihe-in -72.81, -5.27 -53.35, -45.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.383 T790M,V948R None None XRAY 3.0 0.278 0.312 D 331 289 16 0 0 13 [[712, 970]] 1.0 7jxi TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXLA 701 1013 1210.0 VO7:1101 Type1 Inactive DFGin 5.542 16.067 BLBtrans -126.4, -179.97 66.03, 31.68 -87.54, 145.45 161.25, 72.83 92.56, -6.61 out-out out 13.282 Saltbr-out 13.233 HRD-in -72.85, -58.8 84.46, -15.1 out-out-none SNCoon out-none ActLoopNT-out 9.348 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.61 APE8-dihe-in -82.4, 69.83 APE8-rot-na 33.22 APE67-dihe-in -77.96, -2.7 -53.21, -40.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.765 T790M,V948R None None XRAY 2.4 0.21 0.239 A 331 294 19 0 0 14 [[712, 970]] 1.0 7jxl TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7KY0B 700 1007 1210.0 XA4:1101 Type1 Inactive DFGin 4.244 15.439 BLBtrans -160.57, 176.1 77.66, 59.27 -115.51, 105.39 132.91, 62.63 158.65, 57.76 out-out out 13.296 Saltbr-out 10.451 HRD-in -69.02, -53.59 81.26, -3.78 out-out-out SNCooo out-out ActLoopNT-out 9.281 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.26 APE8-dihe-in -79.51, 75.82 APE8-rot-na 31.83 APE67-dihe-in -75.32, -0.28 -59.99, -39.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.269 T790M,V948R None None XRAY 3.1 0.24 0.292 B 331 285 20 0 0 14 [[712, 970]] 1.0 7ky0 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7KY0D 700 1007 1210.0 XA4:1101 Type1 Inactive DFGin 4.302 15.48 BLBtrans -138.98, -176.35 58.31, 55.74 -112.38, 119.92 126.22, 87.9 141.73, 45.73 out-out out 13.342 Saltbr-out 11.554 HRD-in -67.33, -55.84 83.95, -5.94 out-out-none SNCoon out-none ActLoopNT-out 9.101 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.65 APE8-dihe-in -83.77, 71.98 APE8-rot-na 32.22 APE67-dihe-in -72.87, -2.69 -55.69, -38.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.511 T790M,V948R None None XRAY 3.1 0.24 0.292 D 331 294 14 0 0 14 [[712, 970]] 1.0 7ky0 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7U98B 701 1005 1210.0 M1O:1101 Type1 Inactive DFGin 5.609 16.611 BLBtrans -140.13, -174.53 48.89, 57.71 -85.81, 131.72 167.62, 55.27 65.83, 6.33 out-out out 13.577 Saltbr-out 13.535 HRD-in -76.37, -57.65 78.87, -5.89 out-out-out SNCooo out-out ActLoopNT-out 6.917 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 8.89 APE9-dihe-in -69.72, 140.24 APE8-dihe-in -81.34, 67.13 APE8-rot-na 31.34 APE67-dihe-in -70.75, -7.15 -60.08, -43.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.672 APE9-dist-out 8.23 T790M,V948R None None XRAY 3.42 0.216 0.244 B 331 293 12 0 0 12 [[712, 970]] 1.0 7u98 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7U98C 702 1007 1210.0 M1O:1101 Type1 Inactive DFGin 5.084 16.301 BLBtrans -131.03, -174.08 58.46, 35.85 -67.66, 147.46 158.98, 69.58 40.61, 29.57 out-out out 13.611 Saltbr-out 12.985 HRD-in -71.79, -58.03 80.81, -14.3 out-out-out SNCooo out-out ActLoopNT-out 8.704 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.85 APE8-dihe-in -70.24, 67.11 APE8-rot-na 29.02 APE67-dihe-in -75.38, -2.45 -60.79, -40.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.302 T790M,V948R None None XRAY 3.42 0.216 0.244 C 331 286 20 0 0 14 [[712, 970]] 1.0 7u98 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7U98D 701 1007 1210.0 M1O:1101 Type1 Inactive DFGin 5.734 16.43 BLBtrans -133.75, -174.31 52.82, 34.09 -65.47, 149.8 160.31, 69.84 72.06, -122.62 out-out out 13.719 Saltbr-out 13.804 HRD-in -70.87, -55.75 80.84, -15.72 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.2 APE8-dihe-in -87.12, 65.67 APE8-rot-na 32.02 APE67-dihe-in -75.78, -0.75 -61.11, -41.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.534 T790M,V948R None None XRAY 3.42 0.216 0.244 D 331 285 22 0 0 16 [[712, 970]] 1.0 7u98 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8F1WA 701 1007 1210.0 R2E:1101 Type1 Inactive DFGin 5.28 16.379 BLBtrans -128.45, -172.46 54.26, 51.11 -103.7, 148.5 152.13, 74.45 76.8, -16.65 out-out out 13.469 Saltbr-out 13.206 HRD-in -72.99, -57.24 80.64, -5.91 out-out-out SNCooo out-out ActLoopNT-out 8.08 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -99.43, -53.06 APE9-dihe-in -72.87, 140.92 APE8-dihe-in -84.73, 81.02 APE8-rot-na 32.64 APE67-dihe-in -74.93, -2.07 -61.05, -46.98 APE12-dist-na 19.316 APE11-dist-na 16.495 APE10-dist-na 12.256 APE9-dist-in 7.556 T790M,V948R None None XRAY 3.2 0.233 0.274 A 331 303 4 0 0 4 [[712, 970]] 1.0 8f1w TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8F1WB 700 1007 1210.0 R2E:1101 Type1 Inactive DFGin 4.358 15.734 BLBtrans -129.99, -174.05 52.25, 52.37 -111.11, 152.05 129.92, 81.6 82.17, -3.69 out-out out 13.437 Saltbr-out 14.463 HRD-in -72.48, -56.45 81.7, -6.34 out-out-none SNCoon out-none ActLoopNT-out 8.913 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.67 APE8-dihe-in -84.49, 80.46 APE8-rot-na 32.73 APE67-dihe-in -74.43, -1.94 -61.83, -47.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.727 T790M,V948R None None XRAY 3.2 0.233 0.274 B 331 288 17 0 0 14 [[712, 970]] 1.0 8f1w TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8F1WC 700 1007 1210.0 R2E:1101 Type1 Inactive DFGin 5.411 16.33 BLBtrans -128.1, -172.08 53.52, 45.92 -101.71, 133.48 161.59, 77.0 98.24, -6.72 out-out out 13.166 Saltbr-out 13.462 HRD-in -72.8, -56.41 81.38, -6.01 out-out-none SNCoon out-none ActLoopNT-out 8.716 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.55 APE8-dihe-in -84.21, 80.52 APE8-rot-na 32.64 APE67-dihe-in -74.76, -1.9 -61.65, -47.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.682 T790M,V948R None None XRAY 3.2 0.233 0.274 C 331 290 18 0 0 14 [[712, 970]] 1.0 8f1w TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8F1WD 700 1007 1210.0 R2E:1101 Type1 Inactive DFGin 5.365 16.324 BLBtrans -129.36, -171.8 54.41, 47.64 -102.11, 148.89 154.19, 76.79 83.64, -7.92 out-out out 13.848 Saltbr-out 18.195 HRD-in -72.16, -56.36 81.51, -6.86 out-out-out SNCooo out-out ActLoopNT-out 8.707 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.09, -47.67 APE9-dihe-in -78.16, 141.77 APE8-dihe-in -84.0, 80.49 APE8-rot-na 32.67 APE67-dihe-in -74.57, -2.54 -61.13, -46.62 APE12-dist-na 18.773 APE11-dist-na 15.914 APE10-dist-na 11.838 APE9-dist-in 7.585 T790M,V948R None None XRAY 3.2 0.233 0.274 D 331 304 4 0 0 4 [[712, 970]] 1.0 8f1w TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6Z4DA 701 984 1210.0 8BS:1101 Type1 Inactive DFGin 5.582 16.911 BLBtrans -114.92, 175.53 65.11, 24.14 -66.3, 140.38 162.98, 75.92 74.11, -7.31 out-out out 14.215 Saltbr-out 12.826 HRD-in -79.35, -52.49 82.58, -13.07 out-out-out SNCooo out-out ActLoopNT-out 7.154 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.13 APE8-dihe-in -73.43, 66.21 APE8-rot-na 29.65 APE67-dihe-in -74.75, -4.91 -55.02, -43.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.316 T790M,V948R None None XRAY 2.0 0.195 0.221 A 333 269 15 0 0 13 [[712, 970]] 1.0 6z4d TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7A6JA 699 982 1210.0 R2E:1101 Type1 Inactive DFGin 5.453 16.618 BLBtrans -120.02, 179.59 64.16, 32.38 -80.87, 139.28 157.53, 71.5 71.31, -7.23 out-out out 13.937 Saltbr-out 13.528 HRD-in -70.46, -55.09 81.28, -12.68 out-out-out SNCooo out-out ActLoopNT-out 8.076 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.23 APE8-dihe-in -79.55, 65.7 APE8-rot-na 33.45 APE67-dihe-in -69.43, -10.33 -53.39, -41.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.191 T790M,V948R None None XRAY 2.0 0.192 0.216 A 333 270 14 0 0 14 [[712, 970]] 1.0 7a6j TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7A6KA 700 984 1210.0 R28:1101 Type1 Inactive DFGin 5.672 16.532 BLBtrans -113.38, -178.74 66.45, 17.22 -70.85, 135.38 162.57, 71.95 93.0, -13.33 out-out out 13.46 Saltbr-out 13.73 HRD-in -79.28, -53.26 81.06, -6.15 out-out-out SNCooo out-out ActLoopNT-out 7.541 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 9.43 APE9-dihe-in -71.11, 126.54 APE8-dihe-in -79.69, 67.98 APE8-rot-na 32.03 APE67-dihe-in -70.72, -4.33 -56.41, -46.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.919 APE9-dist-out 8.412 T790M,V948R None None XRAY 2.0 0.193 0.22 A 333 266 19 0 0 14 [[712, 970]] 1.0 7a6k TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7A6KB 700 982 1210.0 R28:1101 Type1 Inactive DFGin 5.343 15.868 BLBtrans -129.04, -178.67 62.57, 21.81 -71.79, 126.77 154.84, 72.08 83.61, 999.0 out-none out 13.481 Saltbr-none 999.0 HRD-in -76.88, -46.01 73.74, -7.71 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 133.51 APE9-dihe-in -84.9, 130.78 APE8-dihe-in -77.41, 66.48 APE8-rot-na 31.07 APE67-dihe-in -72.33, -5.85 -61.23, -39.01 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.682 T790M,V948R None None XRAY 2.0 0.193 0.22 B 333 260 23 0 0 17 [[712, 970]] 1.0 7a6k TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7A6KC 700 984 1210.0 R28:1101 Type1 Inactive DFGin 5.484 15.789 BLBtrans -131.64, -174.72 61.99, 29.43 -91.7, 131.8 164.71, 64.61 141.03, 999.0 out-none out 13.417 Saltbr-none 999.0 HRD-in -76.77, -47.52 68.03, -0.55 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -68.19 APE9-dihe-in -103.13, 125.01 APE8-dihe-in -86.91, 68.74 APE8-rot-na 26.28 APE67-dihe-in -74.92, -1.32 -57.04, -40.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.556 T790M,V948R None None XRAY 2.0 0.193 0.22 C 333 262 23 0 0 17 [[712, 970]] 1.0 7a6k TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7A6KD 702 984 1210.0 R28:1101 Type1 Inactive DFGin 5.163 15.725 BLBtrans -125.34, -177.59 58.43, 37.54 -98.25, 128.03 151.98, 71.88 111.44, 999.0 out-out out 13.356 Saltbr-out 9.148 HRD-in -91.6, -48.16 65.02, 0.98 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.46 APE8-dihe-in -80.89, 70.4 APE8-rot-na 24.1 APE67-dihe-in -72.66, -6.51 -57.4, -40.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.69 T790M,V948R None None XRAY 2.0 0.193 0.22 D 333 255 28 0 0 18 [[712, 970]] 1.0 7a6k TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4I24A 700 1014 1210.0 1C9:9001 Type1 Inactive DFGin 5.661 16.446 BLBtrans -124.79, -177.97 65.95, 19.32 -65.94, 134.77 167.42, 77.24 100.69, -25.94 out-out out 13.775 Saltbr-out 12.829 HRD-in -83.3, -47.74 80.82, -14.46 out-out-out SNCooo out-out ActLoopNT-out 6.554 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.29 APE8-dihe-in -74.66, 58.68 APE8-rot-na 28.63 APE67-dihe-in -76.18, -6.25 -49.37, -41.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.306 T790M None None XRAY 1.8 0.21 0.239 A 329 295 20 0 0 13 [[712, 970]] 1.0 4i24 TYR_EGFR_HUMAN TYR 8.2e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4I24B 700 1014 1210.0 1C9:9001 Type1 Inactive DFGin 5.538 16.502 BLBtrans -127.49, -179.81 73.27, 11.54 -60.91, 132.74 167.82, 75.33 94.21, -14.75 out-out out 14.01 Saltbr-out 12.566 HRD-in -82.33, -49.07 80.92, -16.04 out-out-out SNCooo out-out ActLoopNT-out 6.75 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -77.49, -14.51 APE9-dihe-in -107.27, 109.9 APE8-dihe-in -79.94, 72.64 APE8-rot-na 30.26 APE67-dihe-in -75.43, -3.71 -52.62, -43.52 APE12-dist-na 999.0 APE11-dist-na 13.81 APE10-dist-na 9.903 APE9-dist-in 7.489 T790M None None XRAY 1.8 0.21 0.239 B 329 304 11 0 0 11 [[712, 970]] 1.0 4i24 TYR_EGFR_HUMAN TYR 8.2e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5YU9A 700 1017 1210.0 1E8:1101 Type1 Inactive DFGin 5.636 16.954 BLBtrans -125.21, 170.75 68.2, 24.35 -60.36, 133.88 165.48, 79.68 84.64, -7.33 out-out out 14.105 Saltbr-out 13.516 HRD-in -68.25, -48.62 80.2, -8.38 out-out-out SNCooo out-out ActLoopNT-out 6.623 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -1.9 APE9-dihe-in -68.14, 141.09 APE8-dihe-in -83.65, 70.23 APE8-rot-na 33.58 APE67-dihe-in -73.94, -5.17 -61.14, -38.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.164 APE9-dist-out 8.325 T790M None None XRAY 1.95 0.203 0.222 A 331 302 16 0 0 12 [[712, 970]] 1.0 5yu9 TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5YU9B 699 1011 1210.0 1E8:1101 Type1 Inactive DFGin 5.578 16.845 BLBtrans -112.64, 177.79 63.79, 24.69 -63.05, 134.78 163.6, 79.76 84.83, -6.07 out-out out 14.134 Saltbr-out 14.101 HRD-in -68.46, -48.55 81.72, -13.78 out-out-out SNCooo out-out ActLoopNT-out 6.519 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.76 APE8-dihe-in -84.19, 72.46 APE8-rot-na 28.56 APE67-dihe-in -69.8, -15.04 -60.51, -37.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.185 T790M None None XRAY 1.95 0.203 0.222 B 331 295 18 0 0 13 [[712, 970]] 1.0 5yu9 TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5YU9C 697 1021 1210.0 1E8:1101 Type1 Inactive DFGin 5.67 16.652 BLBtrans -122.9, 169.66 70.91, 24.34 -64.7, 134.43 166.29, 81.69 95.85, -22.56 out-out out 13.826 Saltbr-out 13.722 HRD-in -69.25, -50.19 81.18, -12.38 out-out-out SNCooo out-out ActLoopNT-out 6.805 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 107.02 APE9-dihe-in -132.02, 145.19 APE8-dihe-in -82.44, 66.61 APE8-rot-na 16.92 APE67-dihe-in -75.02, -8.16 -59.33, -36.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.992 APE9-dist-out 8.462 T790M None None XRAY 1.95 0.203 0.222 C 331 306 16 0 0 12 [[712, 970]] 1.0 5yu9 TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5YU9D 700 1012 1210.0 1E8:1101 Type1 Inactive DFGin 5.71 16.766 BLBtrans -121.88, 171.32 72.04, 19.53 -55.62, 135.13 163.77, 67.42 83.7, -13.08 out-out out 13.758 Saltbr-out 13.361 HRD-in -69.57, -49.84 80.09, -14.78 out-out-out SNCooo out-out ActLoopNT-out 6.597 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 151.91 APE8-dihe-in -82.51, 73.37 APE8-rot-na 30.07 APE67-dihe-in -70.37, -12.42 -60.68, -39.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.027 T790M None None XRAY 1.95 0.203 0.222 D 331 300 13 0 0 13 [[712, 970]] 1.0 5yu9 TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4I22A 700 1014 1210.0 IRE:9001 Type1 Inactive DFGin 5.463 16.472 BLBtrans -123.06, -178.62 68.31, 18.86 -65.27, 136.35 169.35, 71.91 94.28, -11.28 out-out out 13.657 Saltbr-out 12.177 HRD-in -84.17, -49.73 82.39, -10.75 out-out-out SNCooo out-out ActLoopNT-out 7.105 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.61 APE8-dihe-in -75.03, 69.55 APE8-rot-na 29.55 APE67-dihe-in -78.29, -2.11 -50.24, -41.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.297 T790M,L858R,V948R None None XRAY 1.71 0.198 0.224 A 329 297 18 0 0 13 [[712, 970]] 1.0 4i22 TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9GC6A 698 1014 1210.0 A1IZ9:1101 Type1 Inactive DFGin 5.957 16.941 BLBtrans -113.12, 175.88 60.62, 26.23 -63.47, 128.84 168.58, 71.18 91.95, -9.99 out-out out 14.335 Saltbr-out 14.537 HRD-in -71.17, -49.86 79.87, -17.21 out-out-none SNCoon out-none ActLoopNT-out 6.959 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 106.41 APE8-dihe-in -75.37, 66.64 APE8-rot-na 32.21 APE67-dihe-in -70.19, -10.44 -46.86, -45.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.769 V948R None None XRAY 1.901 0.269 0.323 A 330 298 19 0 0 14 [[712, 970]] 1.0 9gc6 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9GC6B 698 1014 1210.0 A1IZ9:1101 Type1 Inactive DFGin 6.022 16.945 BLBtrans -106.07, 175.04 65.48, 26.54 -65.44, 134.22 173.29, 73.76 87.47, -11.31 out-out out 14.006 Saltbr-out 14.543 HRD-in -70.88, -46.09 77.35, -9.72 out-out-none SNCoon out-none ActLoopNT-out 6.972 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 53.82 APE8-rot-na 32.21 APE67-dihe-in -63.66, -17.55 -53.54, -40.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V948R None None XRAY 1.901 0.269 0.323 B 330 300 17 0 0 14 [[712, 970]] 1.0 9gc6 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9GDVA 702 985 1210.0 Q6K:1101 Type1 Inactive DFGin 5.61 15.829 BLBtrans -107.73, 177.69 65.5, 33.1 -82.9, 128.34 164.87, 70.16 94.26, -7.41 out-none out 12.642 Saltbr-none 999.0 HRD-in -75.43, -53.65 76.33, -6.74 none-out-none SNCnon out-none ActLoopNT-out 7.915 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 143.05 APE8-dihe-in -77.71, 68.12 APE8-rot-na 28.54 APE67-dihe-in -70.85, -6.5 -47.64, -45.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.734 V948R None None XRAY 2.218 0.235 0.293 A 330 262 22 0 0 15 [[712, 970]] 1.0 9gdv TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9GDVB 702 985 1210.0 Q6K:1101 Type1 Inactive DFGin 4.579 15.491 BLBtrans -111.43, 179.21 66.37, 26.18 -74.59, 129.04 147.85, 63.03 60.16, 37.36 out-none out 12.538 Saltbr-none 999.0 HRD-out -124.5, 90.89 -69.11, -17.02 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 149.32 APE8-dihe-in -80.3, 68.77 APE8-rot-na 2.98 APE67-dihe-in -69.33, -16.36 -50.05, -40.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.271 V948R None None XRAY 2.218 0.235 0.293 B 330 267 17 0 0 17 [[712, 970]] 1.0 9gdv TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4HJOA 703 984 1210.0 AQ4:61001 Type1 Inactive DFGin 5.388 16.318 BLBtrans -124.68, 174.05 69.43, 22.17 -65.94, 132.43 169.63, 65.82 88.49, -10.45 out-out out 13.639 Saltbr-out 13.3 HRD-in -64.45, -47.69 77.22, -1.5 out-out-out SNCooo out-out ActLoopNT-out 6.744 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -74.38, 153.06 APE9-dihe-in -116.04, 141.68 APE8-dihe-in -81.16, 64.87 APE8-rot-na 343.76 APE67-dihe-in -72.42, -1.21 -62.83, -39.56 APE12-dist-na 16.454 APE11-dist-na 13.108 APE10-dist-na 13.885 APE9-dist-out 8.594 V948R None None XRAY 2.75 0.231 0.253 A 337 278 4 0 0 0 [[712, 970]] 1.0 4hjo TYR_EGFR_HUMAN TYR 8.7e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6JXTA 697 984 1210.0 YY3:1101 Type1 Inactive DFGin 5.195 16.591 BLBtrans -111.23, 162.67 71.78, 29.16 -65.79, 134.38 147.38, 75.02 84.23, -1.16 out-out out 13.295 Saltbr-out 13.347 HRD-in -69.01, -50.38 82.25, -13.8 out-out-in SNCooi out-in ActLoopNT-out 7.742 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.48, 149.35 APE9-dihe-in -133.32, 157.03 APE8-dihe-in -83.78, 82.27 APE8-rot-na 27.63 APE67-dihe-in -60.52, -27.7 -61.29, -42.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.584 APE9-dist-in 7.368 E865A,E866A,K867A None None XRAY 2.307 0.218 0.239 A 331 284 4 0 0 2 [[712, 970]] 1.0 6jxt TYR_EGFR_HUMAN TYR 5.8e-87 297.3 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5X2AB 700 1022 1210.0 7XO:1105,ANP:1106 Type1,ATPlike Inactive DFGin 5.521 16.379 BLBtrans -118.08, 178.13 68.28, 22.21 -63.57, 132.1 161.37, 67.84 99.95, -15.3 out-out out 13.892 Saltbr-out 13.505 HRD-in -67.87, -49.57 81.65, -13.01 out-out-out SNCooo out-out ActLoopNT-out 6.364 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -63.35, -22.61 APE9-dihe-in -95.03, 108.56 APE8-dihe-in -83.98, 72.85 APE8-rot-na 21.28 APE67-dihe-in -71.39, -9.89 -59.75, -39.3 APE12-dist-na 15.726 APE11-dist-na 13.245 APE10-dist-na 9.274 APE9-dist-in 7.568 T790M,V948R None None XRAY 1.85 0.176 0.219 B 331 322 0 0 0 0 [[712, 970]] 1.0 5x2a TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5X2AA 700 1011 1210.0 7XO:1107,ANP:1108 Type1,Allosteric Inactive DFGin 5.565 16.303 BLBtrans -120.52, 179.71 70.51, 14.21 -61.87, 136.6 165.52, 70.66 90.66, -18.93 out-out out 13.778 Saltbr-out 13.104 HRD-in -79.48, -46.8 73.07, -8.08 out-out-none SNCoon out-none ActLoopNT-out 6.728 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.51 APE8-dihe-in -84.48, 76.35 APE8-rot-na 26.1 APE67-dihe-in -71.21, -12.48 -60.14, -38.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.762 T790M,V948R None None XRAY 1.85 0.176 0.219 A 331 297 13 0 0 13 [[712, 970]] 1.0 5x2a TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9GC5A 699 1012 1210.0 A1IZ8:1101 Type1.5_Back Inactive DFGin 5.6 16.79 BLBtrans -111.5, 178.08 56.68, 33.75 -72.61, 130.73 159.77, 72.21 91.77, -17.39 out-out out 13.965 Saltbr-out 14.411 HRD-in -70.39, -48.68 78.33, -15.6 out-out-none SNCoon out-none ActLoopNT-out 7.191 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.89 APE8-dihe-in -80.7, 65.69 APE8-rot-na 33.21 APE67-dihe-in -72.03, -12.63 -42.92, -46.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.813 V948R None None XRAY 1.909 0.222 0.261 A 330 300 14 0 0 14 [[712, 970]] 1.0 9gc5 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9GC5B 699 1012 1210.0 A1IZ8:1101 Type1.5_Back Inactive DFGin 5.661 16.654 BLBtrans -109.72, -178.6 59.87, 20.79 -66.15, 129.46 164.43, 72.22 95.52, -21.82 out-out out 13.959 Saltbr-out 13.791 HRD-in -73.8, -49.03 79.45, -14.18 out-out-none SNCoon out-none ActLoopNT-out 6.897 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.92 APE8-dihe-in -77.6, 64.28 APE8-rot-na 29.47 APE67-dihe-in -68.23, -11.21 -44.13, -46.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.961 V948R None None XRAY 1.909 0.222 0.261 B 330 300 14 0 0 14 [[712, 970]] 1.0 9gc5 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8PO3A 706 1001 1210.0 2II:1101 Type1.5_Front Inactive DFGin 5.664 17.494 BLBtrans -107.39, 172.75 67.19, 30.39 -61.3, 132.08 163.82, 77.02 76.73, -7.92 out-out out 15.498 Saltbr-out 15.217 HRD-in -73.05, -52.43 81.25, -11.07 out-out-out SNCooo out-out ActLoopNT-out 6.766 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.29 APE8-dihe-in -83.1, 70.29 APE8-rot-na 33.27 APE67-dihe-in -73.75, -3.18 -47.3, -43.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.215 V948R None None XRAY 2.13 0.222 0.269 A 330 279 13 0 0 13 [[712, 970]] 1.0 8po3 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4RIWB 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.947 14.509 None -144.94, -140.84 60.54, -94.56 67.75, 16.38 293.55, 125.63 -72.75, -24.64 in-in in 8.962 Saltbr-in 2.577 HRD-out -81.5, 87.13 -71.92, 10.44 in-in-none SNCiin in-none ActLoopNT-in 2.914 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.11 APE8-dihe-in -64.72, 105.47 APE8-rot-na 338.81 APE67-dihe-in -78.09, 0.73 -66.98, -35.92 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.339 V948R,F997A,L1001A None None XRAY 3.1 0.233 0.287 B 345 293 4 0 0 4 [[712, 970]] 1.0 4riw TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4RIWD 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 6.016 14.399 None -147.43, -141.55 60.24, -94.38 68.1, 17.38 294.17, 126.48 -72.23, -23.22 in-in in 8.845 Saltbr-in 3.081 HRD-in -78.23, -46.1 60.09, 5.38 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.64, 111.47 APE9-dihe-in -129.74, 134.09 APE8-dihe-in -62.84, 106.17 APE8-rot-na 337.89 APE67-dihe-in -78.37, 3.33 -65.15, -34.97 APE12-dist-na 11.397 APE11-dist-na 9.946 APE10-dist-na 9.723 APE9-dist-in 6.015 V948R,F997A,L1001A None None XRAY 3.1 0.233 0.287 D 345 297 0 0 0 0 [[712, 970]] 1.0 4riw TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4RIXB 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.919 14.579 None -139.87, -153.46 71.8, -106.42 74.55, 12.91 300.13, 117.16 -73.01, -18.89 in-in in 8.778 Saltbr-in 2.851 HRD-out -79.93, 91.22 -73.37, 9.67 in-in-none SNCiin in-none ActLoopNT-in 2.815 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.04 APE8-dihe-in -57.54, 105.82 APE8-rot-na 336.15 APE67-dihe-in -83.65, 5.55 -71.82, -34.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.644 V948R,F997A,L1001A None None XRAY 3.1 0.21 0.258 B 345 293 4 0 0 4 [[712, 970]] 1.0 4rix TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4RIXD 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.984 14.396 None -138.76, -155.76 70.86, -102.17 73.98, 14.44 299.1, 114.44 -71.0, -18.03 in-in in 8.433 Saltbr-in 2.13 HRD-in -75.74, -46.31 59.89, 5.04 in-in-in SNCiii in-in ActLoopNT-in 2.879 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.43, 115.77 APE9-dihe-in -128.43, 136.25 APE8-dihe-in -57.6, 106.59 APE8-rot-na 335.5 APE67-dihe-in -81.04, 4.3 -70.58, -32.32 APE12-dist-na 11.336 APE11-dist-na 10.144 APE10-dist-na 10.428 APE9-dist-in 5.987 V948R,F997A,L1001A None None XRAY 3.1 0.21 0.258 D 345 297 0 0 0 0 [[712, 970]] 1.0 4rix TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4RIYB 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.952 14.655 None -154.99, 131.23 -173.19, -76.87 64.96, 12.46 300.69, 132.23 -71.94, -28.32 in-in in 8.685 Saltbr-in 2.95 HRD-out -79.99, 96.69 -77.78, 9.7 in-in-none SNCiin in-none ActLoopNT-in 2.884 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.59 APE8-dihe-in -76.15, 93.2 APE8-rot-na 346.43 APE67-dihe-in -79.33, 6.83 -64.49, -46.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.35 V948R,F997A,L1001A None None XRAY 2.981 0.221 0.267 B 345 293 4 0 0 4 [[712, 970]] 1.0 4riy TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4RIYD 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.892 14.398 None -146.72, -160.68 90.34, -82.61 63.94, 14.36 297.22, 112.71 -69.53, -27.12 in-in in 8.333 Saltbr-in 2.327 HRD-in -73.91, -45.57 61.02, 4.8 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.34, 113.28 APE9-dihe-in -130.38, 137.58 APE8-dihe-in -69.37, 99.85 APE8-rot-na 344.82 APE67-dihe-in -75.56, 6.57 -58.1, -42.52 APE12-dist-na 11.232 APE11-dist-na 10.201 APE10-dist-na 9.961 APE9-dist-in 6.258 V948R,F997A,L1001A None None XRAY 2.981 0.221 0.267 D 345 297 0 0 0 0 [[712, 970]] 1.0 4riy TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8EMEA 700 1007 1210.0 No_ligand No_ligand Inactive DFGin 3.986 13.839 None -137.24, 168.8 64.53, 119.38 -177.18, 999.0 59.37, 99.1 999.0, 999.0 out-out out 13.889 Saltbr-out 11.311 HRD-none 999.0, 999.0 999.0, 84.53 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -73.83, -4.04 999.0, -46.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 3.32 0.285 0.318 A 331 267 31 0 0 21 [[712, 970]] 1.0 8eme TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3GOPA 676 1018 1210.0 No_ligand No_ligand Inactive DFGin 5.906 14.618 None -81.86, 151.27 -44.37, 145.0 -81.84, 77.36 22.41, 114.96 178.29, 999.0 in-na in 8.85 Saltbr-na 999.0 HRD-in -65.46, -52.27 80.15, -7.53 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.74 APE8-dihe-in -83.3, 83.47 APE8-rot-na 22.34 APE67-dihe-in -72.58, -12.26 -49.6, -41.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.954 K745M None None XRAY 2.8 0.213 0.259 A 361 300 29 0 0 18 [[712, 970]] 1.0 3gop TYR_EGFR_HUMAN TYR 3.2e-86 295.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7JXIB 702 1004 1210.0 8BS:1101 Type1 Inactive DFGin 4.641 14.267 None -127.65, -24.47 -127.47, 108.69 -144.39, 139.56 46.55, 108.56 -178.57, -134.7 out-out out 13.417 Saltbr-out 12.201 HRD-in -66.29, -55.89 76.11, -7.1 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.37 APE8-dihe-in -80.39, 70.42 APE8-rot-na 30.87 APE67-dihe-in -73.29, -5.7 -53.51, -46.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.511 T790M,V948R None None XRAY 3.0 0.278 0.312 B 331 274 25 0 0 17 [[712, 970]] 1.0 7jxi TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7KY0C 700 1007 1210.0 XA4:1101 Type1 Inactive DFGin 5.795 16.213 None -140.43, -171.69 57.16, 56.26 -102.57, 14.47 175.77, 70.43 -64.23, -166.18 out-out out 13.304 Saltbr-out 13.711 HRD-in -68.5, -58.2 83.04, -5.79 out-out-none SNCoon out-none ActLoopNT-out 7.955 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.7 APE8-dihe-in -78.4, 79.01 APE8-rot-na 31.55 APE67-dihe-in -75.24, -1.85 -59.7, -43.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.59 T790M,V948R None None XRAY 3.1 0.24 0.292 C 331 289 19 0 0 14 [[712, 970]] 1.0 7ky0 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7U98A 701 1007 1210.0 M1O:1101 Type1 Inactive DFGin 5.292 16.461 None -131.78, -176.31 58.71, 37.78 -55.07, -79.17 157.63, 65.72 -77.42, -26.86 out-out out 13.976 Saltbr-out 14.699 HRD-in -68.9, -54.72 82.24, -14.81 out-out-none SNCoon out-none ActLoopNT-out 7.121 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.12 APE8-rot-na 30.49 APE67-dihe-in -75.19, -1.88 -59.47, -39.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 3.42 0.216 0.244 A 331 287 20 0 0 14 [[712, 970]] 1.0 7u98 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7ZYQB 700 984 1210.0 V58:1101 Type1 Inactive DFGin 5.144 13.295 None -125.84, 171.99 57.78, 57.18 -116.53, 999.0 63.4, 95.28 999.0, 999.0 out-out out 12.868 Saltbr-out 9.546 HRD-in -76.02, -55.26 80.29, -12.9 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.05 APE8-dihe-in -82.27, 69.03 APE8-rot-na 30.38 APE67-dihe-in -72.67, -5.58 -56.39, -41.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.47 T790M,V948R None None XRAY 2.1 0.199 0.223 B 333 260 25 0 0 19 [[712, 970]] 1.0 7zyq TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2JIVA 700 984 1210.0 HKI:1797 Type1.5_Back Inactive DFGin 5.403 14.133 None -99.08, 179.7 43.08, 110.41 179.69, 142.51 59.42, 1.67 76.47, 0.27 out-out out 13.396 Saltbr-out 10.108 HRD-in -70.42, -63.2 89.91, -17.22 out-out-none SNCoon out-none ActLoopNT-out 6.928 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -38.75 APE9-dihe-in -107.53, 155.69 APE8-dihe-in -72.57, 63.91 APE8-rot-na 32.44 APE67-dihe-in -65.29, 3.74 -54.81, -43.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.932 APE9-dist-in 7.634 T790M None None XRAY 3.5 0.253 0.284 A 328 270 15 0 0 14 [[712, 970]] 1.0 2jiv TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8H7XB 697 1018 1210.0 No_ligand No_ligand Inactive DFGinter 8.474 4.539 None -64.56, 138.69 -118.16, 46.75 -84.7, 147.88 264.74, 132.9 65.94, 48.18 in-in in 7.861 Saltbr-in 2.743 HRD-in -95.26, -40.89 71.41, -6.98 in-out-none SNCion out-none ActLoopNT-out 5.284 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.76 APE8-dihe-in -79.73, 83.74 APE8-rot-na 34.28 APE67-dihe-in -52.0, -45.23 -70.34, -44.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.766 T790M,C797S None None XRAY 3.404 0.189 0.256 B 330 304 7 0 0 7 [[712, 970]] 1.0 8h7x TYR_EGFR_HUMAN TYR 6.2e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5XGNB 697 1019 1210.0 No_ligand No_ligand Inactive DFGinter 8.875 4.226 None -66.63, 139.03 -107.84, 34.93 -81.79, 142.31 255.34, 148.71 68.34, 31.51 in-in in 7.665 Saltbr-in 3.035 HRD-in -69.88, -38.92 70.25, -6.15 in-out-out SNCioo out-out ActLoopNT-out 5.544 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 59.97, 52.07 APE9-dihe-in -79.54, 147.42 APE8-dihe-in -94.06, 88.44 APE8-rot-na 27.93 APE67-dihe-in -64.82, -35.28 -54.4, -44.67 APE12-dist-na 12.386 APE11-dist-na 15.391 APE10-dist-na 15.977 APE9-dist-in 7.966 T790M,C797S None None XRAY 3.0 0.222 0.251 B 331 308 5 0 0 4 [[712, 970]] 1.0 5xgn TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2JITB 697 1018 1210.0 No_ligand No_ligand Inactive DFGinter 8.643 4.268 None -65.09, 133.17 -114.41, 36.11 -84.27, 149.81 251.72, 154.26 60.91, 22.91 in-in in 8.03 Saltbr-in 3.164 HRD-in -71.83, -62.45 88.36, -10.04 in-out-in SNCioi out-in ActLoopNT-out 4.332 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.87, 136.57 APE9-dihe-in -138.24, 154.81 APE8-dihe-in -91.0, 80.78 APE8-rot-na 356.06 APE67-dihe-in -73.95, 11.71 -56.2, -43.16 APE12-dist-na 15.983 APE11-dist-na 15.773 APE10-dist-na 15.968 APE9-dist-in 7.412 T790M None None XRAY 3.1 0.209 0.249 B 327 312 0 0 0 0 [[712, 970]] 1.0 2jit TYR_EGFR_HUMAN TYR 8e-88 300.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2JIUB 695 1004 1210.0 No_ligand No_ligand Inactive DFGinter 8.912 4.352 None -62.48, 140.76 -118.63, 55.68 -100.13, 143.92 258.8, 146.55 62.94, 28.63 in-in in 8.076 Saltbr-in 2.959 HRD-in -72.84, -64.99 94.58, -35.5 in-in-in SNCiii in-in ActLoopNT-in 3.489 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.69, 118.33 APE9-dihe-in -133.73, 161.67 APE8-dihe-in -92.78, 73.55 APE8-rot-na 15.24 APE67-dihe-in -66.9, -25.87 -50.11, -38.12 APE12-dist-na 16.383 APE11-dist-na 15.152 APE10-dist-na 16.405 APE9-dist-in 7.624 T790M None None XRAY 3.05 0.214 0.277 B 328 310 0 0 0 0 [[712, 970]] 1.0 2jiu TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4G5PB 697 1018 1210.0 No_ligand No_ligand Inactive DFGinter 8.694 4.058 None -102.27, 130.04 -119.39, 11.63 -56.23, 139.55 268.64, 132.98 83.16, 48.09 in-in in 7.531 Saltbr-in 2.909 HRD-in -73.51, -36.65 75.01, -67.24 in-out-out SNCioo out-out ActLoopNT-out 5.511 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 136.61 APE9-dihe-in -136.04, 152.17 APE8-dihe-in -101.09, 85.15 APE8-rot-na 34.16 APE67-dihe-in -61.97, -21.6 -60.83, -40.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 16.343 APE9-dist-out 8.971 T790M None None XRAY 3.17 0.247 0.323 B 330 303 8 0 0 8 [[712, 970]] 1.0 4g5p TYR_EGFR_HUMAN TYR 8.3e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
3IKAB 697 1017 1210.0 No_ligand No_ligand Inactive DFGinter 8.717 4.604 None -75.22, 143.75 -113.63, 39.19 -87.68, 145.68 264.7, 149.87 65.59, 19.15 in-in in 7.748 Saltbr-in 2.721 HRD-in -71.43, -56.54 82.98, -12.02 in-out-in SNCioi out-in ActLoopNT-out 5.388 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.44, 137.59 APE9-dihe-in -139.25, 153.6 APE8-dihe-in -85.59, 76.58 APE8-rot-na 26.0 APE67-dihe-in -74.82, -10.46 -52.9, -35.6 APE12-dist-na 16.909 APE11-dist-na 15.822 APE10-dist-na 16.726 APE9-dist-in 7.764 T790M None None XRAY 2.9 0.21 0.257 B 331 310 2 0 0 2 [[712, 970]] 1.0 3ika TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4WD5B 697 1016 1210.0 No_ligand No_ligand Inactive DFGinter 9.248 4.425 None -72.57, 139.36 -100.73, 10.04 -62.48, 143.44 260.7, 137.62 58.63, 39.1 in-out in 7.729 Saltbr-out 3.739 HRD-out -90.94, 114.01 -64.78, -40.5 out-out-out SNCooo out-out ActLoopNT-out 4.978 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -60.44, 137.91 APE9-dihe-in -137.14, 159.08 APE8-dihe-in -84.32, 85.1 APE8-rot-na 36.97 APE67-dihe-in -61.6, -40.36 -63.96, -40.18 APE12-dist-na 16.585 APE11-dist-na 15.83 APE10-dist-na 16.945 APE9-dist-out 8.836 T790M None None XRAY 3.3 0.211 0.239 B 331 304 5 0 0 5 [[712, 970]] 1.0 4wd5 TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5UWDA 702 984 1210.0 8OV:9001 Type1 Inactive DFGinter 8.718 6.883 None -103.03, 102.14 -79.54, 67.3 -112.01, -2.59 296.52, 123.95 -53.45, -42.68 out-out out 12.173 Saltbr-out 13.169 HRD-in -62.38, -44.86 62.12, -14.75 out-out-out SNCooo out-out ActLoopNT-out 9.302 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 33.47 APE9-dihe-in -110.69, 126.69 APE8-dihe-in -92.9, 52.09 APE8-rot-na 21.1 APE67-dihe-in -67.65, -3.97 -43.65, -47.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.321 APE9-dist-out 9.235 T790M,L858R,V948R None None XRAY 3.06 0.216 0.28 A 329 271 12 0 0 12 [[712, 970]] 1.0 5uwd TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2RF9A 699 983 1210.0 No_ligand No_ligand Inactive DFGout 13.946 6.908 BBAminus -121.77, 171.61 -138.84, 149.59 -128.18, 33.73 287.89, 52.24 57.49, 26.72 out-none out 11.966 Saltbr-none 999.0 HRD-in -57.96, -48.51 81.96, -56.62 none-in-out SNCnio in-out ActLoopNT-in 3.15 ActLoopCT-out TYR APEdihe_ooiai APEdist_aaai APE10-dihe-out 170.52, -17.42 APE9-dihe-out 56.97, 109.88 APE8-dihe-in -40.66, 127.28 APE8-rot-na 329.03 APE67-dihe-in -45.77, -18.55 -54.08, -53.0 APE12-dist-na 999.0 APE11-dist-na 8.375 APE10-dist-na 10.766 APE9-dist-in 6.542 None None None XRAY 3.5 0.272 0.329 A 330 280 5 0 0 2 [[712, 970]] 1.0 2rf9 TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4ZJVA 703 985 1210.0 No_ligand No_ligand Inactive DFGout 13.648 7.793 BBAminus -127.0, 171.58 -126.44, 148.68 -117.71, 34.52 301.49, 64.95 92.13, 1.64 out-out out 12.571 Saltbr-out 8.618 HRD-in -71.09, -45.98 69.32, 4.23 out-in-in SNCoii in-in ActLoopNT-in 2.807 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.99, 123.56 APE9-dihe-in -138.04, 139.86 APE8-dihe-in -81.95, 80.42 APE8-rot-na 33.11 APE67-dihe-in -74.68, -3.27 -50.68, -46.13 APE12-dist-na 12.202 APE11-dist-na 10.543 APE10-dist-na 10.977 APE9-dist-in 7.492 None None None XRAY 2.7 0.181 0.232 A 331 282 1 0 0 0 [[712, 970]] 1.0 4zjv TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4ZJVB 703 982 1210.0 No_ligand No_ligand Inactive DFGout 13.523 7.892 BBAminus -124.84, -179.31 -140.7, 141.17 -113.98, 39.53 310.83, 71.28 73.86, 21.11 out-out out 12.731 Saltbr-out 9.268 HRD-in -65.16, -49.82 70.39, 1.35 out-in-in SNCoii in-in ActLoopNT-in 3.01 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.29, 131.48 APE9-dihe-in -146.27, 149.66 APE8-dihe-in -85.36, 88.82 APE8-rot-na 34.04 APE67-dihe-in -73.12, -6.68 -56.73, -47.09 APE12-dist-na 13.048 APE11-dist-na 11.237 APE10-dist-na 11.34 APE9-dist-in 7.21 None None None XRAY 2.7 0.181 0.232 B 331 273 7 0 0 0 [[712, 970]] 1.0 4zjv TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5HG5A 700 1001 1210.0 633:9001 Type1 Inactive DFGout 14.803 8.364 BBAminus -123.7, 162.96 -128.37, 131.07 -111.5, 16.12 283.55, 100.99 125.19, -6.98 out-out out 13.42 Saltbr-out 11.009 HRD-in -75.53, -48.64 74.12, 0.13 out-in-in SNCoii in-in ActLoopNT-in 2.869 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.29, 133.37 APE9-dihe-in -135.03, 151.84 APE8-dihe-in -78.84, 71.68 APE8-rot-na 29.34 APE67-dihe-in -76.12, -5.73 -47.63, -43.25 APE12-dist-na 12.595 APE11-dist-na 11.415 APE10-dist-na 11.449 APE9-dist-in 7.118 T790M,L858R,V948R None None XRAY 1.52 0.206 0.224 A 329 302 0 0 0 0 [[712, 970]] 1.0 5hg5 TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5HG7A 702 984 1210.0 630:9001 Type1 Inactive DFGout 14.326 8.337 BBAminus -132.67, 173.3 -137.69, 131.94 -112.36, 18.94 289.01, 99.14 120.48, -2.68 out-out out 13.337 Saltbr-out 9.744 HRD-in -74.38, -53.22 72.9, 3.74 out-in-in SNCoii in-in ActLoopNT-in 2.873 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.6, 144.48 APE9-dihe-in -123.53, 137.72 APE8-dihe-in -77.18, 77.49 APE8-rot-na 29.41 APE67-dihe-in -75.59, -6.28 -49.29, -43.46 APE12-dist-na 11.737 APE11-dist-na 8.689 APE10-dist-na 10.085 APE9-dist-in 6.782 T790M,L858R,V948R None None XRAY 1.85 0.216 0.246 A 329 280 3 0 0 0 [[712, 970]] 1.0 5hg7 TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5HG8A 700 999 1210.0 634:9001 Type1 Inactive DFGout 14.824 8.42 BBAminus -120.04, 168.11 -134.21, 135.65 -116.21, 20.34 285.7, 99.23 125.69, -13.05 out-out out 13.481 Saltbr-out 11.185 HRD-in -79.82, -49.01 72.91, 1.6 out-in-in SNCoii in-in ActLoopNT-in 2.847 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.09, 131.22 APE9-dihe-in -129.9, 151.08 APE8-dihe-in -78.57, 73.71 APE8-rot-na 29.52 APE67-dihe-in -75.55, -4.65 -50.28, -43.3 APE12-dist-na 12.521 APE11-dist-na 11.344 APE10-dist-na 11.296 APE9-dist-in 7.094 T790M,L858R,V948R None None XRAY 1.42 0.208 0.213 A 329 300 0 0 0 0 [[712, 970]] 1.0 5hg8 TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5HG9A 702 985 1210.0 63A:9001 Type1 Inactive DFGout 14.39 8.031 BBAminus -124.48, 175.19 -143.23, 132.24 -115.31, 25.27 290.88, 96.34 118.56, -2.84 out-out out 13.425 Saltbr-out 10.805 HRD-in -76.66, -52.48 72.95, 0.75 out-in-in SNCoii in-in ActLoopNT-in 2.866 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.64, 144.64 APE9-dihe-in -126.99, 143.05 APE8-dihe-in -81.54, 85.2 APE8-rot-na 31.9 APE67-dihe-in -76.05, -4.9 -55.51, -39.71 APE12-dist-na 11.85 APE11-dist-na 8.667 APE10-dist-na 10.172 APE9-dist-in 6.721 T790M,L858R,V948R None None XRAY 2.15 0.191 0.241 A 329 280 4 0 0 0 [[712, 970]] 1.0 5hg9 TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5U8LA 702 990 1210.0 O44:9001 Type1 Inactive DFGout 14.815 9.361 BBAminus -121.7, 139.9 -99.4, 120.55 -99.31, -4.66 285.11, 109.75 141.82, -0.88 out-out out 13.654 Saltbr-out 12.561 HRD-in -70.65, -49.86 74.9, -3.35 out-in-in SNCoii in-in ActLoopNT-in 2.847 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.83, 129.47 APE9-dihe-in -131.89, 148.97 APE8-dihe-in -77.16, 74.14 APE8-rot-na 29.74 APE67-dihe-in -76.4, -4.1 -48.81, -42.77 APE12-dist-na 12.182 APE11-dist-na 11.655 APE10-dist-na 11.463 APE9-dist-in 7.113 None None None XRAY 1.6 0.19 0.202 A 329 289 0 0 0 0 [[712, 970]] 1.0 5u8l TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5UG8A 702 985 1210.0 8BP:9001 Type1 Inactive DFGout 14.154 8.218 BBAminus -136.95, 178.16 -138.97, 140.08 -122.37, 24.1 292.18, 96.54 126.49, -17.35 out-out out 13.261 Saltbr-out 10.787 HRD-in -79.51, -49.34 70.66, 4.02 out-in-in SNCoii in-in ActLoopNT-in 2.866 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.2, 139.83 APE9-dihe-in -119.57, 140.26 APE8-dihe-in -79.14, 75.66 APE8-rot-na 29.58 APE67-dihe-in -73.42, -6.5 -50.33, -43.3 APE12-dist-na 11.938 APE11-dist-na 8.839 APE10-dist-na 10.264 APE9-dist-in 6.861 T790M,L858R,V948R None None XRAY 1.46 0.193 0.207 A 329 280 4 0 0 0 [[712, 970]] 1.0 5ug8 TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5UG9A 702 985 1210.0 8AM:9001 Type1 Inactive DFGout 14.257 8.207 BBAminus -137.56, 179.37 -140.87, 137.56 -120.13, 23.73 290.74, 97.27 126.22, -18.83 out-out out 13.293 Saltbr-out 10.693 HRD-in -78.33, -49.72 70.86, 4.97 out-in-in SNCoii in-in ActLoopNT-in 2.858 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.76, 138.99 APE9-dihe-in -120.58, 137.1 APE8-dihe-in -77.47, 74.07 APE8-rot-na 30.0 APE67-dihe-in -74.27, -6.2 -49.29, -43.04 APE12-dist-na 12.02 APE11-dist-na 8.895 APE10-dist-na 10.135 APE9-dist-in 6.864 T790M,L858R,V948R None None XRAY 1.33 0.195 0.205 A 329 280 4 0 0 0 [[712, 970]] 1.0 5ug9 TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5UGAA 703 985 1210.0 8BM:9001 Type1 Inactive DFGout 14.653 8.259 BBAminus -135.66, 174.07 -125.55, 131.08 -113.25, 24.65 287.39, 110.13 125.08, -19.22 out-out out 13.276 Saltbr-out 10.633 HRD-in -79.29, -52.3 75.94, 2.9 out-in-in SNCoii in-in ActLoopNT-in 2.783 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.23, 135.61 APE9-dihe-in -132.36, 142.32 APE8-dihe-in -74.87, 80.04 APE8-rot-na 29.35 APE67-dihe-in -76.19, -4.88 -52.02, -42.4 APE12-dist-na 12.138 APE11-dist-na 10.954 APE10-dist-na 10.799 APE9-dist-in 7.005 T790M,L858R,V948R None None XRAY 1.82 0.235 0.264 A 329 283 0 0 0 0 [[712, 970]] 1.0 5uga TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5UGCA 702 985 1210.0 8BS:9001 Type1 Inactive DFGout 14.396 8.262 BBAminus -131.19, 172.02 -138.19, 139.68 -122.92, 19.28 287.71, 102.44 122.8, -6.46 out-out out 13.418 Saltbr-out 10.829 HRD-in -75.41, -48.99 67.88, 4.79 out-in-in SNCoii in-in ActLoopNT-in 2.811 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.27, 140.43 APE9-dihe-in -121.9, 140.0 APE8-dihe-in -80.12, 76.64 APE8-rot-na 31.38 APE67-dihe-in -74.2, -5.62 -50.31, -42.01 APE12-dist-na 12.007 APE11-dist-na 8.905 APE10-dist-na 10.23 APE9-dist-in 6.881 T790M,L858R,V948R None None XRAY 1.58 0.201 0.223 A 329 280 4 0 0 0 [[712, 970]] 1.0 5ugc TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4I1ZA 701 987 1210.0 No_ligand No_ligand Inactive DFGout 14.873 4.045 None -123.84, 156.94 -117.6, 154.19 -127.95, 41.9 206.23, 152.19 82.25, 13.26 out-out out 13.312 Saltbr-out 9.204 HRD-in -77.26, -39.87 64.35, 3.98 out-in-in SNCoii in-in ActLoopNT-in 2.872 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.73, 133.95 APE9-dihe-in -134.0, 149.51 APE8-dihe-in -74.99, 74.17 APE8-rot-na 30.04 APE67-dihe-in -83.17, 2.17 -68.31, -25.86 APE12-dist-na 13.037 APE11-dist-na 11.822 APE10-dist-na 11.398 APE9-dist-in 7.294 T790M,L858R,V948R None None XRAY 3.0 0.189 0.227 A 329 287 0 0 0 0 [[712, 970]] 1.0 4i1z TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4I21A 703 1019 1210.0 No_ligand No_ligand Inactive DFGout 14.75 4.552 None -100.28, 172.71 -126.15, 170.08 -163.08, 33.14 210.49, 157.35 95.37, -18.48 out-out out 12.846 Saltbr-out 9.647 HRD-in -39.7, -18.75 35.21, 19.68 out-in-in SNCoii in-in ActLoopNT-in 2.866 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.28, 128.62 APE9-dihe-in -128.58, 144.56 APE8-dihe-in -73.89, 96.03 APE8-rot-na 28.14 APE67-dihe-in -80.61, -14.84 -75.13, -32.8 APE12-dist-na 12.13 APE11-dist-na 11.768 APE10-dist-na 11.247 APE9-dist-in 7.173 T790M,L858R None None XRAY 3.37 0.233 0.279 A 329 290 0 0 0 0 [[712, 970]] 1.0 4i21 TYR_EGFR_HUMAN TYR 8.6e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4I21B 703 1020 1210.0 No_ligand No_ligand Inactive DFGout 14.754 4.55 None -99.82, 173.29 -125.81, 171.27 -163.87, 32.69 210.88, 156.94 95.05, -18.24 out-out out 12.842 Saltbr-out 9.62 HRD-in -39.87, -18.86 36.39, 17.8 out-in-in SNCoii in-in ActLoopNT-in 2.825 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.87, 127.85 APE9-dihe-in -127.9, 144.31 APE8-dihe-in -73.55, 96.22 APE8-rot-na 28.09 APE67-dihe-in -81.62, -14.13 -75.34, -32.76 APE12-dist-na 12.135 APE11-dist-na 11.769 APE10-dist-na 11.247 APE9-dist-in 7.172 T790M,L858R None None XRAY 3.37 0.233 0.279 B 329 302 0 0 0 0 [[712, 970]] 1.0 4i21 TYR_EGFR_HUMAN TYR 8.6e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2RF9B 701 985 1210.0 No_ligand No_ligand Inactive DFGout 13.677 7.667 None -135.45, 135.37 -89.59, 173.5 -159.16, 36.83 280.02, 95.88 54.88, 39.47 out-none out 12.947 Saltbr-none 999.0 HRD-in -35.92, -46.42 73.77, -11.36 none-in-out SNCnio in-out ActLoopNT-in 3.076 ActLoopCT-out TYR APEdihe_ioiai APEdist_aaao APE10-dihe-in -82.18, 154.3 APE9-dihe-out -131.03, 36.1 APE8-dihe-in -91.14, 62.73 APE8-rot-na 345.67 APE67-dihe-in -51.39, -4.74 -69.87, -65.73 APE12-dist-na 999.0 APE11-dist-na 12.061 APE10-dist-na 8.253 APE9-dist-out 9.864 None None None XRAY 3.5 0.272 0.329 B 330 269 16 0 0 6 [[712, 970]] 1.0 2rf9 TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4I20A 701 987 1210.0 No_ligand No_ligand Inactive DFGout 15.068 4.091 None -125.7, 154.37 -115.95, 140.98 -109.44, 14.57 214.5, 120.81 110.72, -3.64 out-out out 13.214 Saltbr-out 10.498 HRD-in -72.27, -34.7 64.8, -22.69 out-in-in SNCoii in-in ActLoopNT-in 2.809 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.43, 132.98 APE9-dihe-in -132.7, 146.38 APE8-dihe-in -79.32, 93.47 APE8-rot-na 29.59 APE67-dihe-in -71.84, 11.17 -69.52, -44.48 APE12-dist-na 12.558 APE11-dist-na 10.986 APE10-dist-na 11.04 APE9-dist-in 7.592 L858R,V948R None None XRAY 3.34 0.202 0.242 A 329 287 0 0 0 0 [[712, 970]] 1.0 4i20 TYR_EGFR_HUMAN TYR 8.4e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2ITNA 696 1019 1210.0 ANP:2021 ATPlike None DFGin 6.283 15.235 BLAminus -127.19, -173.38 63.95, 79.84 -96.65, 10.56 295.4, 91.5 -73.87, 28.38 in-in in 8.274 Saltbr-in 3.408 HRD-in -81.37, -44.82 70.79, -0.2 in-in-none SNCiin in-none ActLoopNT-in 2.843 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 98.73 APE8-dihe-in -79.18, 91.37 APE8-rot-na 30.4 APE67-dihe-in -69.96, -4.57 -72.15, -41.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.674 G719S None None XRAY 2.47 0.201 0.267 A 327 304 9 0 0 9 [[712, 970]] 1.0 2itn TYR_EGFR_HUMAN TYR 9.6e-87 296.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2ITVA 696 1019 1210.0 ANP:2020 ATPlike None DFGin 6.216 15.481 BLAminus -132.41, -173.63 61.69, 81.35 -94.21, 13.19 293.51, 90.37 -58.84, 7.8 in-in in 8.584 Saltbr-in 3.462 HRD-in -75.87, -46.5 68.4, 1.6 in-in-none SNCiin in-none ActLoopNT-in 2.737 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.23 APE8-dihe-in -83.21, 92.63 APE8-rot-na 31.24 APE67-dihe-in -66.41, -6.91 -75.93, -39.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.569 L858R None None XRAY 2.47 0.197 0.242 A 327 303 9 0 0 9 [[712, 970]] 1.0 2itv TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5J9ZA 696 1020 1210.0 6HJ:1101 Type1 None DFGin 6.232 15.757 BLAminus -138.58, -164.56 57.88, 71.43 -86.37, 17.12 309.51, 126.8 -45.81, -60.55 in-in in 8.649 Saltbr-in 2.954 HRD-in -68.38, -55.75 71.97, -7.78 in-in-none SNCiin in-none ActLoopNT-in 2.987 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 169.67 APE8-dihe-in -76.27, 71.14 APE8-rot-na 34.32 APE67-dihe-in -73.66, -10.96 -65.96, -35.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.794 T790M None None XRAY 2.5 0.198 0.239 A 325 291 15 0 0 15 [[712, 970]] 1.0 5j9z TYR_EGFR_HUMAN TYR 7.9e-88 300.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6JX4A 696 1018 1210.0 YY3:1101 Type1 None DFGin 6.538 15.295 BLAminus -153.26, -174.41 59.27, 71.1 -94.69, 11.38 288.28, 101.84 -61.51, -40.3 in-in in 8.089 Saltbr-in 3.167 HRD-in -72.1, -56.13 75.51, 1.81 in-in-none SNCiin in-none ActLoopNT-in 2.76 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 44.4 APE9-dihe-in -64.43, 143.52 APE8-dihe-in -93.62, 106.36 APE8-rot-na 34.75 APE67-dihe-in -65.07, -25.73 -81.11, -32.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.137 APE9-dist-in 7.793 T790M None None XRAY 2.531 0.213 0.245 A 331 315 8 0 0 8 [[712, 970]] 1.0 6jx4 TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7VRAA 696 1018 1210.0 I0A:1101 Type1 None DFGin 6.329 14.98 BLAminus -141.39, -166.19 53.63, 67.86 -86.81, 26.91 290.4, 77.76 -61.4, -34.62 in-in in 8.262 Saltbr-in 2.7 HRD-in -73.36, -43.6 68.83, -12.22 in-in-none SNCiin in-none ActLoopNT-in 2.816 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 128.24 APE9-dihe-in -138.53, 146.25 APE8-dihe-in -81.73, 106.37 APE8-rot-na 16.59 APE67-dihe-in -71.3, -8.33 -70.5, -37.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.507 APE9-dist-in 6.955 T790M,C797S None None XRAY 2.41 0.221 0.245 A 331 289 15 0 0 11 [[712, 970]] 1.0 7vra TYR_EGFR_HUMAN TYR 3.3e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7VREA 696 1018 1210.0 7VH:1101 Type1 None DFGin 6.536 14.855 BLAminus -135.27, -171.61 56.81, 74.8 -92.4, 15.96 289.99, 73.74 -54.73, -16.72 in-in in 8.209 Saltbr-in 2.854 HRD-in -71.51, -50.16 76.97, -3.83 in-in-none SNCiin in-none ActLoopNT-in 2.785 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 43.94 APE9-dihe-in -79.86, 134.45 APE8-dihe-in -82.74, 99.99 APE8-rot-na 32.04 APE67-dihe-in -80.29, -2.71 -71.55, -29.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.336 APE9-dist-in 7.113 T790M,C797S None None XRAY 2.507 0.203 0.242 A 331 312 11 0 0 8 [[712, 970]] 1.0 7vre TYR_EGFR_HUMAN TYR 3.3e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7ZYPA 695 1019 1210.0 R25:1101 Type1 None DFGin 5.985 16.009 BLAminus -153.74, -167.87 58.65, 77.37 -99.18, 25.22 298.05, 95.24 -63.28, -21.65 in-none in 9.654 Saltbr-none 999.0 HRD-in -69.35, -50.87 70.3, 4.62 none-in-in SNCnii in-in ActLoopNT-in 2.922 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.66, 142.21 APE9-dihe-in -148.7, 155.05 APE8-dihe-in -93.0, 109.16 APE8-rot-na 20.15 APE67-dihe-in -64.26, -18.17 -75.15, -37.25 APE12-dist-na 11.405 APE11-dist-na 10.035 APE10-dist-na 10.094 APE9-dist-in 6.803 T790M,C797S,E865A,E866A,K867A None None XRAY 2.8 0.2 0.228 A 333 305 0 0 0 0 [[712, 970]] 1.0 7zyp TYR_EGFR_HUMAN TYR 3.4e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9KLWA 696 1019 1210.0 A1L53:61101 Type1 None DFGin 5.36 15.016 BLAminus -137.92, -173.21 68.95, 86.53 -103.04, 23.39 302.9, 100.52 -66.02, -20.59 in-in in 8.729 Saltbr-in 3.41 HRD-in -69.44, -47.22 66.72, 12.67 in-in-none SNCiin in-none ActLoopNT-in 2.938 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 149.08 APE8-dihe-in -82.92, 74.1 APE8-rot-na 34.98 APE67-dihe-in -75.3, -8.48 -60.53, -40.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.69 T790M,L858R None None XRAY 2.67 0.2 0.257 A 330 298 14 0 0 13 [[712, 970]] 1.0 9klw TYR_EGFR_HUMAN TYR 8.6e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2ITYA 697 1019 1210.0 IRE:2020 Type1 None DFGin 5.709 14.347 BLAminus -166.22, -170.95 51.79, 94.03 -111.38, 9.95 304.52, 88.76 -48.13, -2.84 in-in in 8.08 Saltbr-in 2.831 HRD-in -75.89, -42.81 70.47, -11.39 in-in-none SNCiin in-none ActLoopNT-in 2.641 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 109.72 APE8-dihe-in -87.66, 98.01 APE8-rot-na 34.48 APE67-dihe-in -68.44, -18.24 -69.59, -44.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.612 None None None XRAY 3.42 0.216 0.26 A 327 300 10 0 0 10 [[712, 970]] 1.0 2ity TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2J5FA 696 1020 1210.0 DJK:3021 Type1 None DFGin 5.657 14.384 BLAminus -144.79, -170.55 64.0, 79.04 -97.73, 24.0 296.97, 99.2 -43.96, -47.9 in-in in 8.267 Saltbr-in 2.813 HRD-in -61.54, -44.58 69.15, -3.0 in-in-none SNCiin in-none ActLoopNT-in 2.636 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 173.56 APE9-dihe-in -112.83, 120.26 APE8-dihe-in -93.5, 101.2 APE8-rot-na 33.0 APE67-dihe-in -64.88, -16.77 -72.19, -43.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.227 APE9-dist-in 7.146 None None None XRAY 3.0 0.194 0.246 A 327 309 8 0 0 8 [[712, 970]] 1.0 2j5f TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6VHNA 696 1019 1210.0 QQJ:1101 Type1 None DFGin 6.268 15.406 BLAminus -137.01, -168.66 62.81, 80.02 -103.64, 23.1 296.88, 98.97 -61.22, -32.89 in-in in 8.718 Saltbr-in 2.854 HRD-in -76.27, -52.37 76.32, -0.98 in-in-none SNCiin in-none ActLoopNT-in 2.981 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.2 APE8-dihe-in -87.73, 89.87 APE8-rot-na 30.35 APE67-dihe-in -72.35, -2.54 -65.87, -41.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.437 None None None XRAY 2.4 0.199 0.2 A 327 286 18 0 0 13 [[712, 970]] 1.0 6vhn TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6VHPA 696 1019 1210.0 QP1:1101 Type1 None DFGin 6.015 15.357 BLAminus -142.26, -172.24 60.71, 82.75 -104.59, 30.45 301.25, 87.72 -60.33, -51.94 in-in in 8.978 Saltbr-in 2.908 HRD-in -76.89, -42.36 67.95, -9.7 in-in-none SNCiin in-none ActLoopNT-in 3.083 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 114.68 APE9-dihe-in -145.42, 154.51 APE8-dihe-in -84.79, 102.47 APE8-rot-na 20.66 APE67-dihe-in -73.32, -7.85 -65.47, -47.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.969 APE9-dist-in 6.918 None None None XRAY 3.6 0.184 0.218 A 327 308 5 0 0 5 [[712, 970]] 1.0 6vhp TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
8G63A 696 1017 1210.0 YXT:1101 Type1 None DFGin 5.529 14.747 BLAminus -143.24, -159.19 52.58, 83.43 -103.22, 21.32 305.76, 90.64 -45.28, -71.59 in-in in 8.933 Saltbr-in 2.765 HRD-in -81.87, -48.78 71.13, -4.89 in-in-none SNCiin in-none ActLoopNT-in 2.615 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 172.53 APE8-dihe-in -91.35, 75.86 APE8-rot-na 29.34 APE67-dihe-in -73.76, 1.1 -57.31, -35.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.515 None None None XRAY 2.5 0.21 0.257 A 327 280 21 0 0 14 [[712, 970]] 1.0 8g63 TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9MSRA 697 1017 1210.0 A1BRC:1101 Type1 None DFGin 5.713 14.487 BLAminus -136.25, -171.1 65.96, 74.47 -93.18, 22.16 295.01, 102.32 -70.66, -22.18 in-in in 8.313 Saltbr-in 2.678 HRD-in -75.31, -48.76 73.94, -5.89 in-in-none SNCiin in-none ActLoopNT-in 2.72 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 153.99 APE8-dihe-in -81.17, 80.82 APE8-rot-na 38.27 APE67-dihe-in -73.27, -2.94 -55.9, -44.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.248 None None None XRAY 1.93 0.199 0.231 A 327 277 23 0 0 13 [[712, 970]] 1.0 9msr TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9NHWA 698 1017 1210.0 A1BYD:1101 Type1 None DFGin 6.053 15.233 BLAminus -144.87, -175.31 63.29, 77.05 -97.54, 24.54 296.32, 92.45 -60.8, -21.57 in-in in 8.651 Saltbr-in 2.717 HRD-in -72.16, -41.92 62.16, 7.57 in-in-none SNCiin in-none ActLoopNT-in 2.897 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.95 APE8-dihe-in -67.02, 107.82 APE8-rot-na 338.68 APE67-dihe-in -78.27, -0.53 -71.56, -34.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.576 None None None XRAY 2.73 0.239 0.268 A 327 280 18 0 0 8 [[712, 970]] 1.0 9nhw TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9NISA 696 1016 1210.0 A1BYK:1101 Type1 None DFGin 6.187 15.633 BLAminus -132.6, -171.59 61.46, 82.06 -102.11, 30.13 293.65, 92.81 -70.22, -9.04 in-in in 8.824 Saltbr-in 2.777 HRD-in -74.0, -46.82 70.75, 2.25 in-in-none SNCiin in-none ActLoopNT-in 2.962 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 151.12 APE8-dihe-in -77.06, 100.01 APE8-rot-na 28.66 APE67-dihe-in -74.77, -0.45 -66.74, -40.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.61 None None None XRAY 2.23 0.235 0.262 A 327 281 17 0 0 10 [[712, 970]] 1.0 9nis TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9NJ7A 698 1017 1210.0 A1BYL:1201 Type1 None DFGin 6.064 15.618 BLAminus -139.58, -169.66 55.85, 84.13 -103.94, 33.72 294.22, 89.03 -68.52, -21.81 in-in in 8.785 Saltbr-in 2.695 HRD-in -73.41, -43.75 67.32, 4.02 in-in-none SNCiin in-none ActLoopNT-in 2.833 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.66 APE8-dihe-in -73.6, 99.04 APE8-rot-na 28.02 APE67-dihe-in -69.1, -11.18 -63.58, -37.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.492 None None None XRAY 2.53 0.233 0.281 A 327 266 30 0 0 15 [[712, 970]] 1.0 9nj7 TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9NJNA 698 1017 1210.0 A1BYS:1101 Type1 None DFGin 6.052 15.492 BLAminus -138.03, -171.71 61.23, 82.93 -102.84, 28.68 295.04, 92.18 -66.73, -16.96 in-in in 8.924 Saltbr-in 3.498 HRD-in -75.24, -45.9 66.95, 7.02 in-in-none SNCiin in-none ActLoopNT-in 2.929 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.33 APE8-dihe-in -71.72, 99.92 APE8-rot-na 26.75 APE67-dihe-in -76.44, 0.7 -63.78, -39.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.484 None None None XRAY 2.24 0.242 0.275 A 327 268 28 0 0 13 [[712, 970]] 1.0 9njn TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9NM0A 697 1018 1210.0 VO7:1101 Type1 None DFGin 6.308 15.402 BLAminus -140.17, -167.49 58.79, 90.01 -111.11, 22.07 294.08, 94.65 -58.39, -24.66 in-in in 8.079 Saltbr-in 3.12 HRD-in -72.56, -49.62 74.29, -11.19 in-in-none SNCiin in-none ActLoopNT-in 2.75 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 98.9 APE8-rot-na 32.89 APE67-dihe-in -82.2, -4.65 -68.26, -37.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.59 0.209 0.247 A 327 273 27 0 0 16 [[712, 970]] 1.0 9nm0 TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9OS6A 697 1017 1210.0 A1CEA:1101 Type1 None DFGin 5.787 14.723 BLAminus -149.68, -169.55 59.63, 82.89 -107.09, 37.79 302.53, 107.91 -67.77, -19.45 in-in in 8.65 Saltbr-in 2.864 HRD-in -73.22, -47.28 69.98, 3.7 in-in-none SNCiin in-none ActLoopNT-in 3.018 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.25 APE8-dihe-in -84.48, 84.59 APE8-rot-na 30.42 APE67-dihe-in -71.55, 6.59 -60.52, -46.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.437 None None None XRAY 2.75 0.211 0.255 A 327 277 22 0 0 14 [[712, 970]] 1.0 9os6 TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9OU9A 697 1017 1210.0 A1CEL:1101 Type1 None DFGin 5.729 14.516 BLAminus -137.92, -166.98 64.48, 74.8 -101.38, 16.31 294.29, 103.58 -68.16, -2.57 in-in in 8.231 Saltbr-in 2.731 HRD-in -76.83, -48.14 74.88, -4.57 in-in-none SNCiin in-none ActLoopNT-in 2.996 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.04 APE8-dihe-in -78.65, 85.77 APE8-rot-na 33.59 APE67-dihe-in -75.11, -2.66 -60.42, -41.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.221 None None None XRAY 2.1 0.214 0.237 A 327 273 27 0 0 14 [[712, 970]] 1.0 9ou9 TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9PMZA 696 1017 1210.0 A1CI6:1101 Type1 None DFGin 5.741 14.718 BLAminus -141.27, -164.81 54.84, 75.79 -92.43, 17.4 302.76, 94.3 -60.93, -6.56 in-in in 8.224 Saltbr-in 2.955 HRD-in -74.27, -47.37 73.88, -9.62 in-in-none SNCiin in-none ActLoopNT-in 2.719 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.7 APE8-dihe-in -72.89, 85.98 APE8-rot-na 29.14 APE67-dihe-in -69.79, -5.39 -61.94, -45.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.228 None None None XRAY 2.33 0.212 0.234 A 327 275 24 0 0 14 [[712, 970]] 1.0 9pmz TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9Q0SA 696 1017 1210.0 A1CNG:1101 Type1 None DFGin 5.818 14.767 BLAminus -143.82, -165.71 57.17, 86.13 -105.9, 15.22 297.18, 94.28 -50.67, -31.29 in-in in 8.231 Saltbr-in 2.931 HRD-in -72.33, -50.59 70.45, -0.8 in-in-none SNCiin in-none ActLoopNT-in 2.875 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 137.72 APE9-dihe-in -139.48, 141.11 APE8-dihe-in -78.02, 96.92 APE8-rot-na 30.24 APE67-dihe-in -74.69, -0.83 -75.68, -39.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.841 APE9-dist-in 6.924 None None None XRAY 2.46 0.199 0.241 A 327 283 18 0 0 8 [[712, 970]] 1.0 9q0s TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7UKVA 696 1018 1210.0 ZRT:1101 Type1 None DFGin 5.936 15.094 BLAminus -138.2, -168.81 62.37, 83.02 -103.85, 24.26 298.25, 88.25 -61.11, -23.87 in-in in 8.689 Saltbr-in 2.994 HRD-in -78.76, -49.38 70.66, 2.89 in-in-none SNCiin in-none ActLoopNT-in 2.973 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 127.73 APE9-dihe-in -144.8, 152.44 APE8-dihe-in -81.13, 94.3 APE8-rot-na 29.19 APE67-dihe-in -72.65, 4.24 -61.82, -42.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.234 APE9-dist-in 6.419 None None None XRAY 2.4 0.213 0.243 A 328 290 13 0 0 6 [[712, 970]] 1.0 7ukv TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4ZAUA 698 1017 1210.0 YY3:1101 Type1 None DFGin 6.017 15.47 BLAminus -144.79, -170.19 56.78, 87.23 -105.06, 22.23 291.67, 100.52 -61.25, -22.95 in-in in 9.092 Saltbr-in 3.506 HRD-in -80.01, -54.39 75.7, 11.54 in-in-none SNCiin in-none ActLoopNT-in 2.891 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 172.16 APE9-dihe-in -149.48, 142.85 APE8-dihe-in -76.13, 94.93 APE8-rot-na 357.17 APE67-dihe-in -79.77, -9.04 -61.73, -40.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.194 APE9-dist-in 6.955 None None None XRAY 2.8 0.196 0.244 A 330 283 14 0 0 5 [[712, 970]] 1.0 4zau TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7U9AA 695 1018 1210.0 M19:61101 Type1 None DFGin 5.969 14.939 BLAminus -138.43, -165.64 57.15, 83.56 -106.29, 27.74 295.81, 111.25 -65.3, -26.31 in-in in 8.739 Saltbr-in 2.631 HRD-in -72.31, -46.85 63.99, 11.01 in-in-none SNCiin in-none ActLoopNT-in 2.885 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 100.67 APE9-dihe-in -142.4, 152.93 APE8-dihe-in -83.85, 92.87 APE8-rot-na 27.47 APE67-dihe-in -72.2, -7.47 -60.15, -49.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.104 APE9-dist-in 6.686 None None None XRAY 2.6 0.196 0.226 A 331 294 9 0 0 4 [[712, 970]] 1.0 7u9a TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
7B85A 697 1020 1210.0 R28:1101 Type1 None DFGin 5.854 14.557 BLAminus -137.84, -174.1 60.63, 85.07 -103.17, 26.09 294.86, 88.23 -63.8, -24.92 in-in in 7.92 Saltbr-in 2.748 HRD-in -73.34, -48.14 69.22, 2.13 in-in-none SNCiin in-none ActLoopNT-in 3.018 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 121.75 APE9-dihe-in -146.0, 163.38 APE8-dihe-in -89.43, 103.15 APE8-rot-na 22.0 APE67-dihe-in -71.22, -17.13 -66.77, -37.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.554 APE9-dist-in 6.798 None None None XRAY 2.5 0.216 0.244 A 333 312 6 0 0 2 [[712, 970]] 1.0 7b85 TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2ITOA 696 1019 1210.0 IRE:2020 Type1 None DFGin 5.748 14.141 BLAminus -140.08, -168.63 58.3, 91.81 -104.54, 8.97 300.44, 102.41 -49.01, 0.84 in-in in 7.815 Saltbr-in 3.161 HRD-in -92.02, -52.4 73.42, 24.83 in-in-none SNCiin in-none ActLoopNT-in 2.691 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 104.39 APE8-dihe-in -85.12, 86.77 APE8-rot-na 30.96 APE67-dihe-in -73.18, -3.24 -69.84, -38.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.404 G719S None None XRAY 3.25 0.197 0.266 A 327 303 9 0 0 9 [[712, 970]] 1.0 2ito TYR_EGFR_HUMAN TYR 9.6e-87 296.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6S9BA 697 1019 1210.0 L1H:1101 Type1 None DFGin 6.118 15.018 BLAminus -148.24, -172.87 65.26, 88.24 -111.59, 23.4 302.91, 91.25 -69.84, -29.04 in-in in 8.68 Saltbr-in 2.766 HRD-in -77.95, -44.62 67.36, 12.41 in-in-none SNCiin in-none ActLoopNT-in 2.789 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 130.6 APE9-dihe-in -136.99, 149.82 APE8-dihe-in -88.88, 86.38 APE8-rot-na 33.73 APE67-dihe-in -72.04, -14.11 -61.18, -35.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.083 APE9-dist-in 7.2 T790M,L858R,E865A,E866A,K867A None None XRAY 3.25 0.186 0.232 A 326 291 15 0 0 12 [[712, 970]] 1.0 6s9b TYR_EGFR_HUMAN TYR 4.4e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6S9CA 696 1019 1210.0 L1K:61101 Type1 None DFGin 5.825 14.722 BLAminus -137.24, -177.45 69.22, 83.47 -102.5, 27.64 296.66, 90.76 -71.56, -8.94 in-in in 8.526 Saltbr-in 2.833 HRD-in -60.53, -44.79 71.19, 1.46 in-in-none SNCiin in-none ActLoopNT-in 2.756 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 105.07 APE9-dihe-in -124.15, 154.71 APE8-dihe-in -82.6, 76.59 APE8-rot-na 34.11 APE67-dihe-in -73.9, -13.53 -58.44, -39.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.508 APE9-dist-in 7.756 T790M,L858R,E865A,E866A,K867A None None XRAY 2.73 0.202 0.225 A 329 299 14 0 0 12 [[712, 970]] 1.0 6s9c TYR_EGFR_HUMAN TYR 4.5e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4RJ4A 697 1018 1210.0 3QW:1101 Type1 None DFGin 5.642 14.869 BLAminus -140.69, -172.61 68.51, 86.31 -99.76, 22.2 296.02, 102.47 -65.67, -16.31 in-in in 8.584 Saltbr-in 2.803 HRD-in -56.37, -48.84 66.69, -1.93 in-in-none SNCiin in-none ActLoopNT-in 2.843 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.29 APE8-dihe-in -86.76, 81.28 APE8-rot-na 21.53 APE67-dihe-in -69.94, -5.61 -53.89, -50.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.202 T790M,L858R,E865A,E866A,K867A None None XRAY 2.78 0.19 0.226 A 331 299 17 0 0 14 [[712, 970]] 1.0 4rj4 TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4RJ7A 697 1018 1210.0 3R1:1102 Type1 None DFGin 6.017 14.69 BLAminus -136.51, -172.32 66.59, 81.87 -97.51, 17.72 294.15, 102.13 -65.84, -16.96 in-in in 8.348 Saltbr-in 3.238 HRD-in -60.19, -50.96 69.31, -0.58 in-in-none SNCiin in-none ActLoopNT-in 2.741 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.16 APE8-dihe-in -78.25, 70.95 APE8-rot-na 29.95 APE67-dihe-in -67.71, -3.19 -45.43, -49.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.219 T790M,L858R,E865A,E866A,K867A None None XRAY 2.55 0.207 0.234 A 331 295 19 0 0 14 [[712, 970]] 1.0 4rj7 TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4RJ8A 697 1018 1210.0 3QS:1102 Type1 None DFGin 5.739 14.839 BLAminus -139.18, -167.47 68.29, 77.56 -89.12, 10.26 294.1, 106.72 -54.86, -20.91 in-in in 8.396 Saltbr-in 2.794 HRD-in -60.49, -55.01 73.42, -2.13 in-in-none SNCiin in-none ActLoopNT-in 2.781 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.62 APE8-dihe-in -86.58, 81.4 APE8-rot-na 26.4 APE67-dihe-in -68.07, -3.17 -48.59, -54.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.12 T790M,L858R,E865A,E866A,K867A None None XRAY 2.5 0.197 0.226 A 331 298 18 0 0 14 [[712, 970]] 1.0 4rj8 TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5C8KA 697 1018 1210.0 4YV:1101 Type1 None DFGin 5.618 14.865 BLAminus -142.56, -168.74 65.75, 82.14 -97.63, 22.27 300.75, 101.92 -60.4, -26.09 in-in in 8.741 Saltbr-in 2.765 HRD-in -67.41, -39.79 60.89, -7.73 in-in-none SNCiin in-none ActLoopNT-in 2.986 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.8 APE8-dihe-in -95.26, 73.85 APE8-rot-na 27.78 APE67-dihe-in -64.32, -5.28 -41.93, -56.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.159 T790M,L858R,E865A,E866A,K867A None None XRAY 3.0 0.202 0.251 A 331 300 17 0 0 15 [[712, 970]] 1.0 5c8k TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5C8MA 697 1019 1210.0 4YW:1101 Type1 None DFGin 6.03 15.137 BLAminus -139.93, -166.43 62.51, 82.79 -104.18, 35.15 303.24, 104.63 -71.47, -7.58 in-in in 8.656 Saltbr-in 2.802 HRD-in -63.0, -55.16 74.91, -5.77 in-in-none SNCiin in-none ActLoopNT-in 3.092 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.92 APE8-dihe-in -91.72, 83.46 APE8-rot-na 23.85 APE67-dihe-in -63.98, -6.63 -55.14, -47.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.308 T790M,L858R,E865A,E866A,K867A None None XRAY 2.9 0.21 0.252 A 331 302 16 0 0 14 [[712, 970]] 1.0 5c8m TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5C8NA 696 1019 1210.0 4YX:1102 Type1 None DFGin 5.55 14.849 BLAminus -130.09, -164.08 61.96, 83.03 -95.79, 18.7 301.11, 101.32 -62.83, -10.09 in-in in 8.554 Saltbr-in 2.837 HRD-in -74.54, -49.37 73.34, -0.43 in-in-none SNCiin in-none ActLoopNT-in 2.861 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.63 APE8-dihe-in -90.67, 83.94 APE8-rot-na 35.45 APE67-dihe-in -71.85, 0.66 -67.76, -45.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.237 T790M,L858R,E865A,E866A,K867A None None XRAY 2.401 0.204 0.258 A 331 300 17 0 0 14 [[712, 970]] 1.0 5c8n TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5CALA 697 1018 1210.0 4Z8:1101 Type1 None DFGin 5.497 14.495 BLAminus -137.41, -172.89 65.78, 89.63 -103.26, 18.8 297.84, 103.35 -65.07, -18.88 in-in in 8.735 Saltbr-in 2.949 HRD-in -63.06, -53.55 70.57, -1.46 in-in-none SNCiin in-none ActLoopNT-in 3.026 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.13 APE8-dihe-in -87.57, 76.27 APE8-rot-na 28.21 APE67-dihe-in -69.94, -3.46 -48.77, -46.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.071 T790M,L858R,E865A,E866A,K867A None None XRAY 2.7 0.206 0.227 A 331 300 17 0 0 15 [[712, 970]] 1.0 5cal TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5CANA 696 1019 1210.0 4ZB:1102 Type1 None DFGin 5.619 14.735 BLAminus -142.73, -174.9 68.91, 93.29 -106.76, 21.14 296.79, 103.43 -65.99, -14.88 in-in in 8.569 Saltbr-in 2.838 HRD-in -62.3, -49.88 68.9, -1.6 in-in-none SNCiin in-none ActLoopNT-in 2.799 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.26 APE8-dihe-in -87.26, 78.01 APE8-rot-na 20.78 APE67-dihe-in -67.65, -1.03 -49.32, -53.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.199 T790M,L858R,E865A,E866A,K867A None None XRAY 2.8 0.198 0.232 A 331 301 16 0 0 14 [[712, 970]] 1.0 5can TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5CAOA 697 1019 1210.0 4ZG:1101 Type1 None DFGin 5.726 14.535 BLAminus -132.0, -172.67 65.56, 80.31 -104.95, 26.76 323.84, 105.62 -77.97, 14.2 in-in in 8.772 Saltbr-in 3.033 HRD-in -58.9, -58.41 76.18, -10.46 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.94 APE8-dihe-in -90.41, 73.41 APE8-rot-na 26.26 APE67-dihe-in -60.83, -6.66 -44.66, -55.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.42 T790M,L858R,E865A,E866A,K867A None None XRAY 2.6 0.203 0.231 A 331 300 19 0 0 16 [[712, 970]] 1.0 5cao TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5CAPA 697 1019 1210.0 4ZH:1103 Type1 None DFGin 5.965 15.081 BLAminus -134.45, -171.01 71.99, 88.37 -110.44, 24.81 303.88, 121.07 -72.28, -6.86 in-in in 8.389 Saltbr-in 2.786 HRD-in -63.56, -57.8 76.6, -10.03 in-in-none SNCiin in-none ActLoopNT-in 3.14 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.82 APE8-dihe-in -83.94, 76.0 APE8-rot-na 26.21 APE67-dihe-in -67.04, -0.42 -50.69, -48.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.483 T790M,L858R,E865A,E866A,K867A None None XRAY 2.4 0.191 0.213 A 331 303 15 0 0 15 [[712, 970]] 1.0 5cap TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5EM7A 696 1019 1210.0 5Q4:1102 Type1 None DFGin 6.063 14.737 BLAminus -135.51, -175.43 63.24, 90.16 -107.26, 25.15 291.83, 97.24 -73.87, -13.09 in-in in 8.193 Saltbr-in 2.807 HRD-in -60.94, -47.98 66.46, -2.63 in-in-none SNCiin in-none ActLoopNT-in 2.774 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.59 APE8-dihe-in -87.95, 81.76 APE8-rot-na 24.14 APE67-dihe-in -66.12, -4.01 -54.22, -49.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.23 T790M,L858R,E865A,E866A,K867A None None XRAY 2.81 0.19 0.216 A 331 300 17 0 0 14 [[712, 970]] 1.0 5em7 TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5HCXA 696 1018 1210.0 60B:1102 Type1 None DFGin 5.679 14.34 BLAminus -134.75, -168.37 67.26, 84.11 -97.03, 11.58 292.78, 109.41 -56.16, -12.04 in-in in 8.197 Saltbr-in 3.182 HRD-in -55.82, -53.35 72.1, 1.2 in-in-none SNCiin in-none ActLoopNT-in 2.777 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.91 APE8-dihe-in -89.45, 69.04 APE8-rot-na 28.83 APE67-dihe-in -67.35, -11.16 -46.21, -47.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.3 T790M,L858R,E865A,E866A,K867A None None XRAY 2.6 0.194 0.223 A 331 298 17 0 0 14 [[712, 970]] 1.0 5hcx TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5HCZA 696 1019 1210.0 60E:1102 Type1 None DFGin 5.51 14.126 BLAminus -138.48, -168.94 67.59, 84.64 -98.68, 22.07 297.97, 107.23 -59.74, -32.24 in-in in 8.208 Saltbr-in 2.979 HRD-in -55.25, -49.19 68.73, 4.6 in-in-none SNCiin in-none ActLoopNT-in 2.777 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.77 APE8-dihe-in -87.19, 65.54 APE8-rot-na 27.65 APE67-dihe-in -64.96, -12.37 -40.06, -51.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.324 T790M,L858R,E865A,E866A,K867A None None XRAY 2.62 0.196 0.227 A 331 300 17 0 0 14 [[712, 970]] 1.0 5hcz TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
2ITTA 697 1019 1210.0 AEE:2020 Type1 None DFGin 5.936 14.965 BLAminus -130.73, -162.83 54.09, 78.3 -90.96, 8.6 295.86, 89.36 -44.57, 3.1 in-in in 8.368 Saltbr-in 2.867 HRD-in -70.65, -43.73 65.16, 6.34 in-in-none SNCiin in-none ActLoopNT-in 2.821 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.78 APE8-dihe-in -88.12, 98.9 APE8-rot-na 27.6 APE67-dihe-in -72.01, -6.18 -71.82, -40.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.493 L858R None None XRAY 2.73 0.212 0.262 A 327 302 9 0 0 9 [[712, 970]] 1.0 2itt TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5X26A 697 1020 1210.0 7XO:1101 Type1 None DFGin 6.188 14.935 BLAminus -153.57, -170.14 58.63, 70.59 -94.54, 18.38 292.51, 110.93 -60.72, -39.59 in-in in 8.548 Saltbr-in 3.317 HRD-in -64.24, -45.47 69.82, 6.31 in-in-none SNCiin in-none ActLoopNT-in 2.835 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.99 APE8-dihe-in -94.19, 95.15 APE8-rot-na 32.94 APE67-dihe-in -63.12, -36.92 -65.94, -42.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.448 L858R None None XRAY 2.951 0.197 0.222 A 327 302 9 0 0 9 [[712, 970]] 1.0 5x26 TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5X27A 697 1020 1210.0 7XR:1101 Type1 None DFGin 6.089 14.567 BLAminus -142.52, -171.15 59.08, 68.89 -91.56, 16.87 296.22, 103.35 -59.61, -40.88 in-in in 8.476 Saltbr-in 3.407 HRD-in -67.74, -41.55 62.13, 9.32 in-in-none SNCiin in-none ActLoopNT-in 2.795 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.75 APE8-dihe-in -94.41, 99.92 APE8-rot-na 33.71 APE67-dihe-in -62.5, -41.39 -64.95, -42.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.156 L858R None None XRAY 2.952 0.205 0.238 A 327 302 9 0 0 9 [[712, 970]] 1.0 5x27 TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5X28A 697 1020 1210.0 7XU:1101 Type1 None DFGin 6.242 14.981 BLAminus -155.25, -168.54 56.92, 67.25 -92.6, 16.38 291.1, 113.77 -60.0, -38.56 in-in in 8.766 Saltbr-in 2.872 HRD-in -64.09, -44.41 72.37, 3.05 in-in-none SNCiin in-none ActLoopNT-in 2.907 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.7 APE8-dihe-in -90.21, 91.04 APE8-rot-na 33.64 APE67-dihe-in -63.4, -43.04 -64.77, -43.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.502 L858R None None XRAY 2.952 0.211 0.25 A 327 310 9 0 0 9 [[712, 970]] 1.0 5x28 TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5XDLA 696 1018 1210.0 8JC:1101 Type1 None DFGin 6.15 14.871 BLAminus -146.3, -172.59 64.93, 71.28 -94.1, 9.83 302.09, 99.18 -52.93, -42.05 in-in in 8.394 Saltbr-in 3.228 HRD-in -74.03, -53.77 76.73, 1.67 in-in-none SNCiin in-none ActLoopNT-in 3.156 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 59.31 APE8-rot-na 32.98 APE67-dihe-in -74.19, -13.64 -84.48, -30.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 L858R None None XRAY 2.7 0.212 0.256 A 331 292 17 0 0 15 [[712, 970]] 1.0 5xdl TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
9U8CD 696 987 1210.0 A1L8T:61101 Type1 None DFGin 5.518 14.842 BLAminus -152.89, -164.88 57.37, 59.02 -76.65, 17.66 286.7, 98.09 -55.38, -41.88 in-in in 8.871 Saltbr-in 3.187 HRD-in -114.09, -29.54 63.53, -55.66 in-in-none SNCiin in-none ActLoopNT-in 3.462 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.4 APE8-dihe-in -82.7, 101.15 APE8-rot-na 29.1 APE67-dihe-in -63.15, -43.97 -69.62, -36.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.518 None None None XRAY 3.5 0.275 0.3 D 338 285 7 0 0 4 [[712, 970]] 1.0 9u8c TYR_EGFR_HUMAN TYR 1.7e-85 292.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
6D8EA 696 1019 1210.0 FZP:1101 Type1.5_Back None DFGin 6.042 15.059 BLAminus -138.11, -172.24 64.79, 63.43 -86.6, 14.58 312.63, 81.25 -43.94, -59.79 in-in in 8.652 Saltbr-in 2.645 HRD-in -72.15, -45.77 63.05, 4.69 in-in-none SNCiin in-none ActLoopNT-in 3.016 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 112.81 APE9-dihe-in -139.79, 164.58 APE8-dihe-in -99.25, 105.5 APE8-rot-na 28.33 APE67-dihe-in -68.5, -6.69 -82.32, -41.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.866 APE9-dist-in 7.175 None None None XRAY 2.537 0.212 0.243 A 327 304 9 0 0 5 [[712, 970]] 1.0 6d8e TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
4RJ5A 697 1019 1210.0 3QY:1101 Type1.5_Back None DFGin 6.144 15.305 BLAminus -139.13, -172.0 64.67, 84.34 -102.51, 37.37 294.94, 103.28 -69.92, -22.45 in-in in 8.602 Saltbr-in 2.803 HRD-in -64.72, -40.04 62.76, -16.92 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.1 APE8-dihe-in -84.86, 78.78 APE8-rot-na 27.08 APE67-dihe-in -69.19, -9.72 -53.68, -42.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.385 T790M,L858R,E865A,E866A,K867A None None XRAY 3.1 0.195 0.229 A 331 296 20 0 0 16 [[712, 970]] 1.0 4rj5 TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5CAQA 697 1018 1210.0 4ZJ:1102 Type1.5_Back None DFGin 5.668 14.915 BLAminus -137.02, -170.07 67.33, 79.05 -91.72, 13.18 294.21, 102.26 -60.56, -10.03 in-in in 8.672 Saltbr-in 2.802 HRD-in -60.07, -52.9 72.53, 1.36 in-in-none SNCiin in-none ActLoopNT-in 2.794 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.08 APE8-dihe-in -79.35, 76.04 APE8-rot-na 30.69 APE67-dihe-in -65.52, -10.47 -45.15, -52.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.989 T790M,L858R,E865A,E866A,K867A None None XRAY 2.5 0.185 0.224 A 331 301 16 0 0 14 [[712, 970]] 1.0 5caq TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5CASA 696 1019 1210.0 4ZQ:1102 Type1.5_Back None DFGin 5.648 14.99 BLAminus -138.57, -167.77 68.04, 80.06 -91.6, 15.8 296.16, 107.26 -57.65, -21.97 in-in in 8.912 Saltbr-in 2.832 HRD-in -67.55, -52.18 71.84, 1.99 in-in-none SNCiin in-none ActLoopNT-in 2.788 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.6 APE8-dihe-in -82.22, 70.93 APE8-rot-na 30.15 APE67-dihe-in -66.03, -7.47 -43.73, -55.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.053 T790M,L858R,E865A,E866A,K867A None None XRAY 2.1 0.184 0.209 A 331 299 17 0 0 13 [[712, 970]] 1.0 5cas TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5CAUA 696 1018 1210.0 4ZR:1102 Type1.5_Back None DFGin 5.613 14.906 BLAminus -141.53, -166.31 67.78, 77.4 -89.35, 12.82 295.09, 107.73 -56.63, -14.57 in-in in 8.802 Saltbr-in 2.786 HRD-in -63.68, -54.38 71.77, 1.7 in-in-none SNCiin in-none ActLoopNT-in 2.815 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.07 APE8-dihe-in -84.23, 76.34 APE8-rot-na 31.68 APE67-dihe-in -64.39, -7.38 -48.76, -54.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.158 T790M,L858R,E865A,E866A,K867A None None XRAY 2.25 0.188 0.211 A 331 297 18 0 0 14 [[712, 970]] 1.0 5cau TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5HCYA 696 1019 1210.0 60D:1102 Type1.5_Back None DFGin 5.564 14.343 BLAminus -135.17, -165.75 65.93, 78.25 -91.02, 13.27 295.4, 107.72 -55.11, -21.47 in-in in 8.422 Saltbr-in 2.796 HRD-in -60.52, -51.07 73.09, 1.44 in-in-none SNCiin in-none ActLoopNT-in 2.793 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.03 APE8-dihe-in -85.54, 71.02 APE8-rot-na 32.48 APE67-dihe-in -70.08, -5.63 -50.19, -42.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.509 T790M,L858R,E865A,E866A,K867A None None XRAY 2.46 0.178 0.221 A 331 302 15 0 0 13 [[712, 970]] 1.0 5hcy TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
5HICA 697 1019 1210.0 63N:1102 Type1.5_Back None DFGin 5.647 14.297 BLAminus -139.13, -164.08 62.52, 78.14 -92.5, 16.36 295.34, 105.72 -61.37, -14.82 in-in in 8.313 Saltbr-in 3.06 HRD-in -60.28, -47.26 67.03, 5.82 in-in-none SNCiin in-none ActLoopNT-in 2.815 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.05 APE8-dihe-in -87.68, 72.67 APE8-rot-na 27.72 APE67-dihe-in -63.88, -10.28 -48.63, -51.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.353 T790M,L858R,E865A,E866A,K867A None None XRAY 2.6 0.191 0.233 A 331 302 16 0 0 14 [[712, 970]] 1.0 5hic TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

TYR_EGFR (Epidermal growth factor receptor)

Total number of chains: 517
Active chains: 99
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 200 38.7% AF-P00533-K1A
DFGin BLBplus 166 32.1% 6V66D
DFGin BLBtrans 92 17.8% 6V66A
DFGin None 13 2.5% 4RIYD
DFGout BBAminus 12 2.3% 5HG8A
DFGin BLAplus 11 2.1% 8A2AA
DFGinter None 8 1.5% 2JIUB
DFGin ABAminus 6 1.2% 9XU9A
DFGout None 5 1.0% 4I1ZA
DFGin BLBminus 4 0.8% 8A2DA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
EGFR_HUMAN 2ITXA P00533 697 1019 1210.0 ANP:2020 ATPlike Active DFGin 5.874 15.737 BLAminus -136.31, -171.94 65.34, 93.22 -111.54, 18.75 298.27, 92.75 -59.44, 2.06 in-in in 9.241 Saltbr-in 3.583 HRD-in -62.41, -44.72 61.37, 7.79 in-in-in SNCiii in-in ActLoopNT-in 2.642 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.73, 124.39 APE9-dihe-in -125.4, 144.12 APE8-dihe-in -79.64, 94.32 APE8-rot-na 30.37 APE67-dihe-in -65.37, -0.17 -61.69, -47.61 APE12-dist-na 11.888 APE11-dist-na 10.151 APE10-dist-na 11.134 APE9-dist-in 7.058 None None None XRAY 2.98 0.191 0.261 A 327 307 4 0 0 4 [[712, 970]] 1.0 2itx Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8HV4A P00533 696 1020 1210.0 PE5:1101,MWU:1102 Allosteric,Type1 Active DFGin 6.099 15.187 BLAminus -130.11, -171.57 60.63, 76.52 -95.44, 10.11 292.65, 96.39 -43.03, -44.61 in-in in 8.302 Saltbr-in 3.322 HRD-in -71.74, -51.9 75.14, 7.17 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.84, 107.0 APE9-dihe-in -115.33, 154.25 APE8-dihe-in -89.19, 79.02 APE8-rot-na 38.66 APE67-dihe-in -72.78, -5.6 -58.65, -42.93 APE12-dist-na 11.758 APE11-dist-na 10.396 APE10-dist-na 11.61 APE9-dist-in 7.39 E865A,E866A,K867A None None XRAY 2.2 0.239 0.275 A 331 304 6 0 0 3 [[712, 970]] 1.0 8hv4 Homo sapiens TYR_EGFR_HUMAN TYR 3.5e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8HV6A P00533 696 1020 1210.0 PE5:1101,N86:1102 Allosteric,Type1 Active DFGin 5.904 15.402 BLAminus -126.97, -177.08 64.65, 81.87 -97.77, 4.79 296.74, 96.36 -40.91, -42.24 in-in in 8.752 Saltbr-in 2.997 HRD-in -69.51, -52.61 72.53, 9.89 in-in-in SNCiii in-in ActLoopNT-in 2.775 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.57, 119.04 APE9-dihe-in -126.13, 154.51 APE8-dihe-in -87.49, 71.86 APE8-rot-na 40.33 APE67-dihe-in -73.01, -0.15 -52.84, -41.89 APE12-dist-na 11.924 APE11-dist-na 10.417 APE10-dist-na 11.442 APE9-dist-in 7.354 E865A,E866A,K867A None None XRAY 2.2 0.249 0.296 A 331 307 3 0 0 0 [[712, 970]] 1.0 8hv6 Homo sapiens TYR_EGFR_HUMAN TYR 3.5e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8HV7A P00533 696 1019 1210.0 PE5:1101,N8O:1102 Allosteric,Type1 Active DFGin 5.965 14.783 BLAminus -130.55, -167.28 53.08, 83.5 -92.28, 13.92 300.31, 94.88 -38.75, -43.45 in-in in 8.203 Saltbr-in 3.059 HRD-in -71.82, -54.11 72.62, 8.95 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.41, 111.31 APE9-dihe-in -116.24, 154.93 APE8-dihe-in -87.4, 80.61 APE8-rot-na 37.2 APE67-dihe-in -74.07, -9.58 -59.54, -41.0 APE12-dist-na 11.66 APE11-dist-na 10.259 APE10-dist-na 11.546 APE9-dist-in 7.176 E865A,E866A,K867A None None XRAY 2.69 0.222 0.29 A 331 301 10 0 0 6 [[712, 970]] 1.0 8hv7 Homo sapiens TYR_EGFR_HUMAN TYR 3.5e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8HV8A P00533 696 1019 1210.0 PE5:1101,N99:1102 Allosteric,Type1 Active DFGin 6.043 15.057 BLAminus -125.96, -170.32 55.74, 82.34 -96.51, 11.07 293.49, 92.75 -34.95, -51.58 in-in in 8.143 Saltbr-in 3.326 HRD-in -73.99, -49.75 71.98, 9.02 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.61, 118.18 APE9-dihe-in -124.65, 150.54 APE8-dihe-in -89.53, 80.34 APE8-rot-na 39.28 APE67-dihe-in -69.5, -3.25 -56.62, -45.74 APE12-dist-na 11.675 APE11-dist-na 10.369 APE10-dist-na 11.219 APE9-dist-in 7.28 C797S,E865A,E866A,K867A None None XRAY 2.4 0.234 0.283 A 331 305 4 0 0 0 [[712, 970]] 1.0 8hv8 Homo sapiens TYR_EGFR_HUMAN TYR 3.5e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8HV9A P00533 696 1019 1210.0 PE5:1101,N9L:1102 Allosteric,Type1 Active DFGin 5.916 15.132 BLAminus -143.82, -178.2 62.01, 78.91 -94.0, 24.14 301.61, 89.09 -64.67, -16.43 in-in in 8.101 Saltbr-in 2.657 HRD-in -69.38, -54.88 68.74, 2.52 in-in-in SNCiii in-in ActLoopNT-in 2.77 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.98, 135.96 APE9-dihe-in -139.68, 157.73 APE8-dihe-in -88.14, 76.12 APE8-rot-na 37.34 APE67-dihe-in -77.83, -6.94 -60.36, -47.24 APE12-dist-na 12.179 APE11-dist-na 10.885 APE10-dist-na 11.275 APE9-dist-in 7.023 E865A,E866A,K867A None None XRAY 2.5 0.254 0.274 A 331 306 4 0 0 0 [[712, 970]] 1.0 8hv9 Homo sapiens TYR_EGFR_HUMAN TYR 3.5e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9BY6A P00533 698 1009 1210.0 PDO:1301,Q6K:1302 Allosteric,Type1 Active DFGin 6.002 15.663 BLAminus -149.77, -168.8 56.86, 79.46 -96.38, 24.13 296.36, 92.05 -63.66, -24.81 in-in in 9.063 Saltbr-in 3.491 HRD-in -75.7, -50.64 70.26, 5.13 in-in-in SNCiii in-in ActLoopNT-in 2.955 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.71, 133.19 APE9-dihe-in -133.13, 146.74 APE8-dihe-in -72.35, 102.77 APE8-rot-na 25.41 APE67-dihe-in -79.34, -8.97 -76.98, -28.96 APE12-dist-na 12.695 APE11-dist-na 9.472 APE10-dist-na 11.091 APE9-dist-in 6.657 None None None XRAY 2.551 0.208 0.245 A 338 311 1 0 0 0 [[712, 970]] 1.0 9by6 Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-87 299.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8HV1A P00533 696 1019 1210.0 PE5:1101,N6N:1102 Allosteric,Type1 Active DFGin 5.813 15.137 BLAminus -141.64, -174.89 64.07, 81.43 -91.77, 15.88 294.7, 99.28 -49.71, -35.13 in-in in 8.633 Saltbr-in 3.064 HRD-in -77.13, -49.05 68.6, 6.98 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.53, 105.98 APE9-dihe-in -114.36, 147.65 APE8-dihe-in -82.64, 80.16 APE8-rot-na 37.74 APE67-dihe-in -74.01, -6.57 -60.27, -40.96 APE12-dist-na 11.899 APE11-dist-na 10.789 APE10-dist-na 11.152 APE9-dist-in 7.211 E865A,E866A,K867A None None XRAY 2.4 0.191 0.219 A 331 309 4 0 0 0 [[712, 970]] 1.0 8hv1 Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8HV3A P00533 696 1020 1210.0 PE5:1101,MWU:1103 Allosteric,Type1 Active DFGin 6.179 15.626 BLAminus -127.58, -179.0 62.59, 85.31 -101.31, 9.93 297.08, 83.02 -46.24, -27.8 in-in in 8.645 Saltbr-in 3.166 HRD-in -72.86, -48.63 69.9, 8.23 in-in-in SNCiii in-in ActLoopNT-in 2.918 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.05, 111.65 APE9-dihe-in -122.27, 146.52 APE8-dihe-in -88.12, 79.7 APE8-rot-na 39.71 APE67-dihe-in -75.54, -1.37 -55.44, -43.37 APE12-dist-na 12.055 APE11-dist-na 10.393 APE10-dist-na 11.129 APE9-dist-in 7.354 E865A,E866A,K867A None None XRAY 2.4 0.214 0.25 A 331 307 3 0 0 0 [[712, 970]] 1.0 8hv3 Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8HV5A P00533 696 1019 1210.0 PE5:1101,N7C:1102 Allosteric,Type1 Active DFGin 5.973 15.251 BLAminus -130.95, 178.54 67.19, 85.27 -98.38, 23.1 296.48, 89.98 -54.53, -35.87 in-in in 8.727 Saltbr-in 3.383 HRD-in -76.07, -52.83 75.02, 1.85 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.39, 115.59 APE9-dihe-in -118.26, 144.05 APE8-dihe-in -81.44, 79.55 APE8-rot-na 38.48 APE67-dihe-in -70.6, -7.98 -54.36, -43.35 APE12-dist-na 11.884 APE11-dist-na 10.562 APE10-dist-na 10.953 APE9-dist-in 7.218 E865A,E866A,K867A None None XRAY 2.2 0.188 0.224 A 331 306 4 0 0 0 [[712, 970]] 1.0 8hv5 Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9BY4A P00533 696 1010 1210.0 PDO:61301,Q6K:61302,PDO:61304,PDO:61305 Allosteric,Type1,Allosteric,Type1 Active DFGin 6.118 15.558 BLAminus -131.58, -170.69 55.04, 91.41 -104.93, 32.17 291.61, 87.59 -69.69, -25.35 in-in in 8.748 Saltbr-in 2.724 HRD-in -74.22, -51.47 72.05, 2.77 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.0, 133.58 APE9-dihe-in -140.48, 146.73 APE8-dihe-in -77.28, 98.44 APE8-rot-na 2.83 APE67-dihe-in -69.73, -13.67 -59.81, -44.15 APE12-dist-na 11.983 APE11-dist-na 10.159 APE10-dist-na 10.796 APE9-dist-in 6.63 None None None XRAY 2.307 0.197 0.22 A 338 315 0 0 0 0 [[712, 970]] 1.0 9by4 Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-87 299.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2JITA P00533 696 1016 1210.0 No_ligand No_ligand Active DFGin 5.141 14.041 BLAminus -143.75, -163.53 58.3, 96.79 -111.32, 23.77 293.79, 72.87 -42.77, -57.72 in-in in 8.261 Saltbr-in 2.502 HRD-in -58.72, -42.55 61.63, -2.2 in-in-in SNCiii in-in ActLoopNT-in 2.786 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -40.92, 138.22 APE9-dihe-in -145.55, 148.59 APE8-dihe-in -78.1, 90.66 APE8-rot-na 34.4 APE67-dihe-in -72.3, 17.7 -56.07, -43.84 APE12-dist-na 11.533 APE11-dist-na 9.544 APE10-dist-na 10.076 APE9-dist-in 6.677 T790M None None XRAY 3.1 0.209 0.249 A 327 299 0 0 0 0 [[712, 970]] 1.0 2jit Homo sapiens TYR_EGFR_HUMAN TYR 8e-88 300.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3UG1A P00533 697 1018 1210.0 No_ligand No_ligand Active DFGin 6.051 15.036 BLAminus -138.29, -170.11 52.83, 84.83 -101.74, 16.86 292.59, 87.32 -38.57, -36.03 in-in in 8.591 Saltbr-in 3.196 HRD-in -75.17, -47.18 65.26, 2.66 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -59.69, 134.48 APE9-dihe-in -145.24, 146.09 APE8-dihe-in -85.72, 94.22 APE8-rot-na 29.06 APE67-dihe-in -67.27, -26.68 -59.74, -42.4 APE12-dist-na 12.324 APE11-dist-na 10.024 APE10-dist-na 10.841 APE9-dist-in 6.691 G719S,T790M None None XRAY 2.75 0.198 0.243 A 334 296 8 0 0 0 [[712, 970]] 1.0 3ug1 Homo sapiens TYR_EGFR_HUMAN TYR 7.9e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN AF-P00533-K1A P00533 704 978 1210.0 No_ligand No_ligand Active DFGin 6.266 14.441 BLAminus -142.4, -173.12 60.96, 66.69 -84.25, 12.66 292.71, 95.04 -61.7, -26.32 in-in in 8.942 Saltbr-in 2.794 HRD-in -75.23, -42.38 67.32, -16.15 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.94, 131.87 APE9-dihe-in -138.04, 147.31 APE8-dihe-in -82.82, 70.63 APE8-rot-na 37.07 APE67-dihe-in -69.79, -13.1 -41.77, -41.11 APE12-dist-na 11.218 APE11-dist-na 9.306 APE10-dist-na 9.628 APE9-dist-in 6.312 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[712, 970]] 1.0 AF-P00533-K1 Homo sapiens TYR_EGFR_HUMAN TYR 5.6e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN AF-P00533-K3A P00533 704 978 1210.0 No_ligand No_ligand Active DFGin 5.936 14.43 BLAminus -146.34, -169.18 58.09, 69.94 -83.67, 15.13 294.25, 94.7 -61.54, -24.2 in-in in 8.756 Saltbr-in 2.733 HRD-in -80.01, -43.56 66.74, -10.06 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.57, 132.53 APE9-dihe-in -139.42, 152.16 APE8-dihe-in -83.1, 63.7 APE8-rot-na 38.0 APE67-dihe-in -69.61, -12.53 -43.06, -39.9 APE12-dist-na 11.57 APE11-dist-na 9.564 APE10-dist-na 9.866 APE9-dist-in 6.216 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[712, 970]] 1.0 AF-P00533-K3 Homo sapiens TYR_EGFR_HUMAN TYR 5.6e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2GS2A P00533 696 1018 1210.0 No_ligand No_ligand Active DFGin 5.997 15.735 BLAminus -138.74, -166.72 52.64, 91.5 -108.19, 27.74 296.19, 95.26 -69.52, 15.47 in-in in 8.904 Saltbr-in 3.285 HRD-in -57.24, -44.44 63.22, -0.15 in-in-in SNCiii in-in ActLoopNT-in 2.757 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -43.38, 131.23 APE9-dihe-in -146.08, 139.35 APE8-dihe-in -71.11, 85.26 APE8-rot-na 34.08 APE67-dihe-in -66.56, -6.13 -61.32, -39.29 APE12-dist-na 12.249 APE11-dist-na 10.341 APE10-dist-na 10.593 APE9-dist-in 6.946 None None None XRAY 2.8 0.248 0.25 A 330 305 3 0 0 0 [[712, 970]] 1.0 2gs2 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7SI1A P00533 695 1020 1210.0 No_ligand No_ligand Active DFGin 6.064 15.686 BLAminus -133.46, -174.76 66.46, 79.13 -98.89, 26.24 291.41, 90.91 -66.32, -23.37 in-in in 9.539 Saltbr-in 3.575 HRD-in -73.1, -47.44 68.75, 2.06 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.26, 135.35 APE9-dihe-in -141.69, 143.81 APE8-dihe-in -69.91, 96.92 APE8-rot-na 342.32 APE67-dihe-in -71.17, -10.6 -59.76, -37.22 APE12-dist-na 12.27 APE11-dist-na 9.283 APE10-dist-na 10.182 APE9-dist-in 6.186 None None None XRAY 1.6 0.193 0.215 A 331 301 8 0 0 0 [[712, 970]] 1.0 7si1 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4TKSA P00533 697 1019 1210.0 No_ligand No_ligand Active DFGin 5.571 14.678 BLAminus -158.56, -164.67 57.08, 87.24 -106.21, 31.57 300.88, 109.29 -73.32, -8.78 in-in in 8.971 Saltbr-in 3.24 HRD-in -59.07, -49.82 64.12, 6.9 in-in-in SNCiii in-in ActLoopNT-in 2.839 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -139.97, 50.24 APE9-dihe-in -122.32, 130.38 APE8-dihe-in -59.17, 108.53 APE8-rot-na 18.98 APE67-dihe-in -72.46, -2.61 -63.0, -34.51 APE12-dist-na 10.288 APE11-dist-na 11.122 APE10-dist-na 8.744 APE9-dist-in 5.829 None None None XRAY 3.202 0.189 0.209 A 332 307 3 0 0 0 [[712, 970]] 1.0 4tks Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2EB2A P00533 696 1019 1210.0 No_ligand No_ligand Active DFGin 5.986 15.614 BLAminus -133.54, -170.99 55.66, 80.97 -94.73, 26.04 295.94, 89.9 -62.59, -8.59 in-in in 8.81 Saltbr-in 3.07 HRD-in -68.4, -48.79 69.57, -2.64 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -37.18, 126.05 APE9-dihe-in -140.69, 139.08 APE8-dihe-in -73.53, 85.93 APE8-rot-na 37.45 APE67-dihe-in -69.5, -7.06 -58.22, -33.12 APE12-dist-na 11.929 APE11-dist-na 10.836 APE10-dist-na 10.769 APE9-dist-in 6.822 None None None XRAY 2.5 0.198 0.253 A 334 305 5 0 0 1 [[712, 970]] 1.0 2eb2 Homo sapiens TYR_EGFR_HUMAN TYR 1e-86 296.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8H7XA P00533 697 1019 1210.0 6GY:1500 Type1 Active DFGin 5.635 13.772 BLAminus -162.89, 168.84 77.21, 81.71 -97.92, 23.57 309.06, 76.3 -58.42, -31.29 in-in in 8.899 Saltbr-in 3.163 HRD-in -78.19, -35.41 64.93, 5.25 in-in-in SNCiii in-in ActLoopNT-in 3.032 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.33, 109.95 APE9-dihe-in -128.71, 142.43 APE8-dihe-in -73.85, 112.86 APE8-rot-na 33.56 APE67-dihe-in -80.76, -11.68 -63.25, -24.22 APE12-dist-na 12.291 APE11-dist-na 9.112 APE10-dist-na 10.289 APE9-dist-in 6.269 T790M,C797S None None XRAY 3.404 0.189 0.256 A 330 299 0 0 0 0 [[712, 970]] 1.0 8h7x Homo sapiens TYR_EGFR_HUMAN TYR 6.2e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6JRXA P00533 696 1017 1210.0 9JO:1101 Type1 Active DFGin 6.44 15.636 BLAminus -145.58, -162.02 54.03, 56.96 -80.77, 53.05 305.17, 63.84 -64.12, -39.93 in-in in 8.427 Saltbr-in 2.596 HRD-in -77.93, -47.62 78.43, -4.56 in-in-in SNCiii in-in ActLoopNT-in 3.037 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.79, 132.45 APE9-dihe-in -156.57, 137.89 APE8-dihe-in -87.12, 89.44 APE8-rot-na 31.88 APE67-dihe-in -67.25, -10.19 -63.92, -36.38 APE12-dist-na 12.449 APE11-dist-na 10.408 APE10-dist-na 10.442 APE9-dist-in 6.999 T790M,C797S None None XRAY 2.201 0.211 0.239 A 331 300 3 0 0 3 [[712, 970]] 1.0 6jrx Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5J9YA P00533 697 1019 1210.0 6HL:1101 Type1 Active DFGin 6.024 15.621 BLAminus -143.43, -160.74 49.91, 84.26 -101.22, 18.94 291.9, 123.66 -49.61, -50.61 in-in in 8.437 Saltbr-in 3.447 HRD-in -67.06, -45.86 64.69, -10.5 in-in-in SNCiii in-in ActLoopNT-in 3.061 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.4, 148.12 APE9-dihe-in -143.13, 151.2 APE8-dihe-in -85.49, 83.09 APE8-rot-na 35.02 APE67-dihe-in -71.5, -10.87 -57.34, -38.25 APE12-dist-na 11.356 APE11-dist-na 10.476 APE10-dist-na 10.43 APE9-dist-in 6.959 None None None XRAY 2.8 0.185 0.237 A 323 300 3 0 0 3 [[712, 970]] 1.0 5j9y Homo sapiens TYR_EGFR_HUMAN TYR 7.7e-88 300.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5X2KA P00533 696 1020 1210.0 0UN:1101 Type1 Active DFGin 6.252 15.402 BLAminus -162.18, -166.94 57.57, 64.19 -89.05, 1.52 298.25, 111.15 -60.1, -40.29 in-in in 8.377 Saltbr-in 3.231 HRD-in -63.42, -47.14 78.88, -6.86 in-in-in SNCiii in-in ActLoopNT-in 2.731 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.48, 127.33 APE9-dihe-in -122.09, 137.71 APE8-dihe-in -92.31, 106.07 APE8-rot-na 35.16 APE67-dihe-in -60.76, -39.83 -65.9, -37.9 APE12-dist-na 13.719 APE11-dist-na 11.84 APE10-dist-na 11.783 APE9-dist-in 7.957 T790M None None XRAY 3.201 0.227 0.244 A 327 314 8 0 0 6 [[712, 970]] 1.0 5x2k Homo sapiens TYR_EGFR_HUMAN TYR 8e-88 300.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4G5PA P00533 696 1016 1210.0 0WN:1101 Type1 Active DFGin 5.344 13.739 BLAminus -124.18, 171.49 77.97, 83.84 -103.09, 36.7 302.05, 70.97 -80.0, -21.33 in-in in 9.077 Saltbr-in 2.945 HRD-in -92.74, -52.87 64.77, 7.63 in-in-in SNCiii in-in ActLoopNT-in 3.173 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.69, 138.82 APE9-dihe-in -143.62, 154.27 APE8-dihe-in -82.6, 99.87 APE8-rot-na 28.42 APE67-dihe-in -75.71, 45.37 -72.06, -48.88 APE12-dist-na 12.129 APE11-dist-na 9.824 APE10-dist-na 10.113 APE9-dist-in 6.844 T790M None None XRAY 3.17 0.247 0.323 A 330 299 0 0 0 0 [[712, 970]] 1.0 4g5p Homo sapiens TYR_EGFR_HUMAN TYR 8.3e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5XDKA P00533 696 1018 1210.0 8JC:1101 Type1 Active DFGin 6.291 15.643 BLAminus -142.28, -172.2 59.56, 71.93 -92.37, 20.08 293.91, 91.35 -59.68, -36.21 in-in in 8.839 Saltbr-in 3.331 HRD-in -63.72, -48.3 76.47, -9.14 in-in-in SNCiii in-in ActLoopNT-in 2.945 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -60.97, 134.48 APE9-dihe-in -140.79, 153.09 APE8-dihe-in -91.71, 90.6 APE8-rot-na 28.11 APE67-dihe-in -61.23, -29.7 -63.54, -39.18 APE12-dist-na 12.179 APE11-dist-na 9.723 APE10-dist-na 10.137 APE9-dist-in 7.217 T790M None None XRAY 2.346 0.219 0.248 A 331 307 1 0 0 0 [[712, 970]] 1.0 5xdk Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5Y9TA P00533 697 1020 1210.0 8RC:1101 Type1 Active DFGin 5.591 14.994 BLAminus -156.88, -164.94 47.09, 81.43 -95.95, 53.11 305.68, 71.53 -51.53, -46.6 in-in in 8.418 Saltbr-in 2.871 HRD-in -67.84, -48.53 70.09, 0.08 in-in-in SNCiii in-in ActLoopNT-in 2.76 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.86, 138.76 APE9-dihe-in -150.48, 158.92 APE8-dihe-in -71.48, 121.98 APE8-rot-na 32.48 APE67-dihe-in -69.03, -24.42 -97.45, -47.49 APE12-dist-na 12.153 APE11-dist-na 10.175 APE10-dist-na 11.054 APE9-dist-in 6.736 T790M None None XRAY 3.25 0.197 0.24 A 333 300 2 0 0 0 [[712, 970]] 1.0 5y9t Homo sapiens TYR_EGFR_HUMAN TYR 8.5e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6S89A P00533 697 1017 1210.0 L0Q:1101 Type1 Active DFGin 6.066 15.231 BLAminus -157.33, -148.66 33.58, 65.8 -75.53, 25.04 305.17, 80.95 -54.51, -45.13 in-in in 8.9 Saltbr-in 3.363 HRD-in -72.93, -41.71 66.27, -3.02 in-in-in SNCiii in-in ActLoopNT-in 3.078 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.23, 124.56 APE9-dihe-in -147.22, 151.7 APE8-dihe-in -85.44, 104.69 APE8-rot-na 30.93 APE67-dihe-in -61.24, -22.25 -66.61, -40.14 APE12-dist-na 12.584 APE11-dist-na 10.214 APE10-dist-na 10.438 APE9-dist-in 6.731 T790M,C797S,E865A,E866A,K867A None None XRAY 2.701 0.191 0.234 A 333 310 0 0 0 0 [[712, 970]] 1.0 6s89 Homo sapiens TYR_EGFR_HUMAN TYR 3.4e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6S8AA P00533 697 1018 1210.0 L0N:1102 Type1 Active DFGin 5.838 15.005 BLAminus -148.49, -160.53 51.03, 78.18 -97.72, 23.3 297.38, 81.01 -61.33, -21.09 in-in in 8.432 Saltbr-in 3.249 HRD-in -78.55, -44.18 72.7, -6.87 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.4, 134.04 APE9-dihe-in -159.56, 141.97 APE8-dihe-in -84.6, 100.84 APE8-rot-na 30.13 APE67-dihe-in -69.92, -1.38 -68.54, -39.36 APE12-dist-na 12.364 APE11-dist-na 10.156 APE10-dist-na 10.195 APE9-dist-in 6.636 T790M,C797S,E865A,E866A,K867A None None XRAY 2.6 0.187 0.207 A 333 313 0 0 0 0 [[712, 970]] 1.0 6s8a Homo sapiens TYR_EGFR_HUMAN TYR 3.4e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7ZYMA P00533 696 1020 1210.0 6GY:1101 Type1 Active DFGin 6.105 14.6 BLAminus -125.58, -171.05 53.24, 83.12 -97.68, 28.42 294.56, 85.3 -63.28, -32.0 in-in in 8.44 Saltbr-in 2.735 HRD-in -69.53, -46.77 68.71, 4.77 in-in-in SNCiii in-in ActLoopNT-in 3.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.21, 113.9 APE9-dihe-in -126.31, 139.74 APE8-dihe-in -66.94, 111.98 APE8-rot-na 339.42 APE67-dihe-in -73.89, -7.64 -66.97, -37.27 APE12-dist-na 12.195 APE11-dist-na 9.561 APE10-dist-na 10.212 APE9-dist-in 6.152 T790M,C797S,E865A,E866A,K867A None None XRAY 2.5 0.194 0.224 A 333 321 4 0 0 0 [[712, 970]] 1.0 7zym Homo sapiens TYR_EGFR_HUMAN TYR 3.4e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7ZYNA P00533 697 1018 1210.0 0UN:1101 Type1 Active DFGin 5.896 15.046 BLAminus -145.65, -166.89 58.05, 78.44 -95.11, 31.85 294.9, 83.85 -65.75, -30.64 in-in in 8.443 Saltbr-in 2.894 HRD-in -73.97, -47.38 70.32, 2.73 in-in-in SNCiii in-in ActLoopNT-in 2.899 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.42, 134.47 APE9-dihe-in -142.75, 146.34 APE8-dihe-in -74.74, 108.36 APE8-rot-na 25.93 APE67-dihe-in -69.45, -12.52 -69.08, -37.0 APE12-dist-na 12.422 APE11-dist-na 9.178 APE10-dist-na 10.479 APE9-dist-in 6.554 T790M,C797S,E865A,E866A,K867A None None XRAY 2.3 0.193 0.223 A 333 317 4 0 0 0 [[712, 970]] 1.0 7zyn Homo sapiens TYR_EGFR_HUMAN TYR 3.4e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9JQ1A P00533 697 1020 1210.0 A1ECU:1101 Type1 Active DFGin 6.005 15.078 BLAminus -137.71, -176.02 59.58, 86.62 -103.58, 31.57 295.05, 88.33 -63.15, -37.97 in-in in 9.031 Saltbr-in 3.048 HRD-in -72.34, -47.27 62.84, 14.69 in-in-in SNCiii in-in ActLoopNT-in 2.745 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.22, 122.29 APE9-dihe-in -118.99, 149.75 APE8-dihe-in -78.94, 88.43 APE8-rot-na 27.81 APE67-dihe-in -74.08, -19.43 -66.07, -32.51 APE12-dist-na 12.153 APE11-dist-na 10.844 APE10-dist-na 11.514 APE9-dist-in 7.168 T790M,C797S,L858R None None XRAY 3.02 0.208 0.274 A 329 301 0 0 0 0 [[712, 970]] 1.0 9jq1 Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7OXBA P00533 696 1019 1210.0 35Z:61101 Type1 Active DFGin 6.005 14.131 BLAminus -130.75, 177.91 66.07, 88.81 -104.72, 27.62 297.72, 96.38 -64.38, -30.99 in-in in 8.408 Saltbr-in 2.726 HRD-in -68.89, -46.33 64.93, 14.34 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.05, 121.7 APE9-dihe-in -135.03, 157.35 APE8-dihe-in -86.06, 80.53 APE8-rot-na 33.4 APE67-dihe-in -72.72, -10.35 -56.13, -39.45 APE12-dist-na 12.247 APE11-dist-na 10.768 APE10-dist-na 10.966 APE9-dist-in 7.086 None None None XRAY 2.56 0.2 0.227 A 326 304 9 0 0 6 [[712, 970]] 1.0 7oxb Homo sapiens TYR_EGFR_HUMAN TYR 8.3e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8WD4A P00533 696 1019 1210.0 W7W:61101 Type1 Active DFGin 5.75 14.795 BLAminus -142.64, -169.33 67.07, 74.8 -90.88, 19.87 297.57, 96.01 -60.59, -23.31 in-in in 8.537 Saltbr-in 3.088 HRD-in -63.82, -45.12 67.16, 11.96 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.75, 139.9 APE9-dihe-in -137.85, 143.39 APE8-dihe-in -80.86, 75.13 APE8-rot-na 35.93 APE67-dihe-in -75.8, -15.34 -53.39, -39.55 APE12-dist-na 999.0 APE11-dist-na 11.806 APE10-dist-na 11.642 APE9-dist-in 7.283 T790M,C797S,L858R None None XRAY 2.55 0.201 0.23 A 329 297 14 0 0 11 [[712, 970]] 1.0 8wd4 Homo sapiens TYR_EGFR_HUMAN TYR 3.4e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6LUBA P00533 696 1018 1210.0 EUX:1101 Type1 Active DFGin 5.507 14.662 BLAminus -139.91, -166.33 58.26, 84.4 -97.54, 21.21 297.41, 97.99 -62.0, -20.37 in-in in 8.855 Saltbr-in 3.016 HRD-in -74.79, -46.54 66.43, 4.09 in-in-in SNCiii in-in ActLoopNT-in 2.876 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.27, 110.9 APE9-dihe-in -113.24, 152.31 APE8-dihe-in -82.46, 86.31 APE8-rot-na 29.56 APE67-dihe-in -71.55, -1.57 -60.93, -45.76 APE12-dist-na 12.33 APE11-dist-na 11.064 APE10-dist-na 11.386 APE9-dist-in 7.295 T790M,C797S,L858R,E865A,E866A,K867A None None XRAY 2.315 0.187 0.226 A 329 301 7 0 0 0 [[712, 970]] 1.0 6lub Homo sapiens TYR_EGFR_HUMAN TYR 3.4e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6LUDA P00533 696 1018 1210.0 YY3:1101 Type1 Active DFGin 5.801 15.169 BLAminus -139.67, -168.77 58.93, 81.91 -96.56, 23.75 296.99, 89.34 -60.73, -21.77 in-in in 8.713 Saltbr-in 3.093 HRD-in -76.11, -49.39 70.4, 3.5 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.38, 124.7 APE9-dihe-in -132.42, 154.45 APE8-dihe-in -81.46, 86.05 APE8-rot-na 32.74 APE67-dihe-in -70.42, -2.77 -62.03, -42.63 APE12-dist-na 12.592 APE11-dist-na 11.47 APE10-dist-na 11.485 APE9-dist-in 7.154 T790M,C797S,L858R,E865A,E866A,K867A None None XRAY 2.05 0.207 0.222 A 329 310 4 0 0 0 [[712, 970]] 1.0 6lud Homo sapiens TYR_EGFR_HUMAN TYR 3.4e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9D3WA P00533 696 1017 1210.0 A1A5L:61101 Type1 Active DFGin 6.181 15.57 BLAminus -136.54, -172.1 77.31, 72.47 -94.15, 28.51 288.41, 98.97 -88.92, 1.56 in-in in 8.774 Saltbr-in 2.829 HRD-in -71.84, -47.28 76.58, -3.9 in-in-in SNCiii in-in ActLoopNT-in 2.783 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.71, 124.38 APE9-dihe-in -135.31, 152.49 APE8-dihe-in -84.29, 71.1 APE8-rot-na 32.71 APE67-dihe-in -77.0, -3.61 -47.12, -41.12 APE12-dist-na 999.0 APE11-dist-na 11.089 APE10-dist-na 11.435 APE9-dist-in 7.186 C797S,E865A,E866A,K867A None None XRAY 2.53 0.271 0.31 A 330 299 11 0 0 11 [[712, 970]] 1.0 9d3w Homo sapiens TYR_EGFR_HUMAN TYR 3.5e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8HVAA P00533 696 1020 1210.0 N9R:1101 Type1 Active DFGin 5.629 14.626 BLAminus -142.87, -171.87 53.74, 75.85 -88.72, 14.21 297.7, 87.76 -41.85, -26.92 in-in in 8.391 Saltbr-in 2.892 HRD-in -78.5, -43.43 65.26, 13.72 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.37, 104.59 APE9-dihe-in -119.11, 152.21 APE8-dihe-in -89.9, 80.48 APE8-rot-na 36.24 APE67-dihe-in -71.75, -14.49 -57.22, -41.26 APE12-dist-na 12.118 APE11-dist-na 10.703 APE10-dist-na 10.819 APE9-dist-in 7.159 E865A,E866A,K867A None None XRAY 2.77 0.243 0.251 A 331 301 8 0 0 4 [[712, 970]] 1.0 8hva Homo sapiens TYR_EGFR_HUMAN TYR 3.5e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6JZ0A P00533 696 1019 1210.0 CKO:1100 Type1 Active DFGin 5.809 15.229 BLAminus -149.65, -162.74 55.21, 78.34 -98.1, 0.99 288.09, 110.24 -45.59, 147.35 in-in in 8.593 Saltbr-in 2.704 HRD-in -72.36, -40.29 62.49, 10.68 in-in-in SNCiii in-in ActLoopNT-in 2.969 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -132.61, 70.32 APE9-dihe-in -120.17, 145.56 APE8-dihe-in -61.09, 122.05 APE8-rot-na 335.79 APE67-dihe-in -79.37, -10.06 -69.5, -36.0 APE12-dist-na 10.463 APE11-dist-na 10.753 APE10-dist-na 10.077 APE9-dist-in 5.803 None None None XRAY 2.86 0.193 0.248 A 326 311 1 0 0 0 [[712, 970]] 1.0 6jz0 Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2J6MA P00533 697 1020 1210.0 AEE:2021 Type1 Active DFGin 5.591 14.628 BLAminus -132.01, -171.36 64.21, 86.56 -104.74, 23.26 301.97, 101.16 -61.7, -5.65 in-in in 8.642 Saltbr-in 3.021 HRD-in -66.75, -41.48 62.82, -7.14 in-in-in SNCiii in-in ActLoopNT-in 2.789 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.86, 117.91 APE9-dihe-in -126.99, 135.18 APE8-dihe-in -74.97, 82.99 APE8-rot-na 39.67 APE67-dihe-in -53.8, -21.73 -47.34, -52.41 APE12-dist-na 11.859 APE11-dist-na 10.864 APE10-dist-na 10.63 APE9-dist-in 6.911 None None None XRAY 3.1 0.202 0.249 A 327 306 0 0 0 0 [[712, 970]] 1.0 2j6m Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6VH4A P00533 696 1019 1210.0 QQM:1101 Type1 Active DFGin 5.858 14.975 BLAminus -138.49, -176.66 62.27, 90.53 -108.38, 27.1 297.52, 94.9 -62.11, -28.1 in-in in 8.621 Saltbr-in 3.08 HRD-in -71.21, -46.14 69.11, 4.32 in-in-in SNCiii in-in ActLoopNT-in 2.802 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.28, 125.12 APE9-dihe-in -131.93, 146.48 APE8-dihe-in -80.03, 99.7 APE8-rot-na 27.92 APE67-dihe-in -73.83, -4.5 -65.24, -44.12 APE12-dist-na 9.865 APE11-dist-na 11.078 APE10-dist-na 10.515 APE9-dist-in 6.81 None None None XRAY 2.8 0.197 0.23 A 327 295 8 0 0 3 [[712, 970]] 1.0 6vh4 Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9MSSA P00533 697 1017 1210.0 A1BYO:1101 Type1 Active DFGin 6.184 14.804 BLAminus -134.33, -176.16 59.86, 84.75 -104.85, 30.86 296.07, 84.32 -66.61, -23.09 in-in in 8.312 Saltbr-in 2.617 HRD-in -73.45, -46.13 67.35, 7.26 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.18, 138.87 APE9-dihe-in -151.48, 152.93 APE8-dihe-in -70.72, 93.17 APE8-rot-na 28.39 APE67-dihe-in -75.67, 1.81 -61.61, -40.33 APE12-dist-na 999.0 APE11-dist-na 10.522 APE10-dist-na 10.737 APE9-dist-in 6.592 None None None XRAY 2.09 0.222 0.237 A 327 286 13 0 0 6 [[712, 970]] 1.0 9mss Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9MSTA P00533 696 1017 1210.0 A1BYN:61101 Type1 Active DFGin 6.037 15.39 BLAminus -134.45, -174.2 61.81, 83.8 -103.16, 31.07 297.52, 96.34 -66.69, -19.6 in-in in 8.744 Saltbr-in 2.949 HRD-in -74.65, -47.17 67.74, 8.39 in-in-in SNCiii in-in ActLoopNT-in 2.818 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.07, 133.39 APE9-dihe-in -149.49, 143.42 APE8-dihe-in -77.29, 100.59 APE8-rot-na 27.65 APE67-dihe-in -79.32, -0.33 -68.37, -36.21 APE12-dist-na 11.759 APE11-dist-na 10.429 APE10-dist-na 10.823 APE9-dist-in 6.619 None None None XRAY 2.57 0.232 0.258 A 327 287 14 0 0 5 [[712, 970]] 1.0 9mst Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9H42A P00533 696 1019 1210.0 A1IR8:61101 Type1 Active DFGin 6.202 15.889 BLAminus -134.07, 179.9 63.14, 84.66 -102.35, 3.72 299.09, 134.62 -33.22, -65.75 in-in in 9.087 Saltbr-in 2.932 HRD-in -73.11, -52.34 78.62, -3.39 in-in-in SNCiii in-in ActLoopNT-in 3.115 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.16, 146.69 APE9-dihe-in -133.99, 146.2 APE8-dihe-in -101.03, 75.13 APE8-rot-na 36.59 APE67-dihe-in -68.67, -11.17 -72.94, -29.53 APE12-dist-na 12.4 APE11-dist-na 10.77 APE10-dist-na 10.767 APE9-dist-in 7.832 None None None XRAY 2.601 0.187 0.245 A 328 324 0 0 0 0 [[712, 970]] 1.0 9h42 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9H47A P00533 696 1019 1210.0 A1IR9:61101 Type1 Active DFGin 6.569 15.831 BLAminus -132.58, -176.52 63.27, 77.94 -102.29, 18.33 296.7, 137.07 -57.08, -63.89 in-in in 8.918 Saltbr-in 2.882 HRD-in -71.97, -52.02 79.14, -6.34 in-in-in SNCiii in-in ActLoopNT-in 3.084 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.16, 151.68 APE9-dihe-in -136.6, 151.52 APE8-dihe-in -101.1, 75.9 APE8-rot-na 36.31 APE67-dihe-in -66.97, -10.87 -73.39, -30.03 APE12-dist-na 12.438 APE11-dist-na 10.958 APE10-dist-na 11.226 APE9-dist-in 7.746 None None None XRAY 2.991 0.202 0.244 A 328 324 0 0 0 0 [[712, 970]] 1.0 9h47 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5FEDA P00533 697 1017 1210.0 5X4:1101 Type1 Active DFGin 6.189 14.687 BLAminus -132.06, 176.3 73.46, 78.92 -101.41, 14.2 298.37, 98.14 -61.64, -39.27 in-in in 8.591 Saltbr-in 2.951 HRD-in -71.77, -46.99 67.31, -1.0 in-in-in SNCiii in-in ActLoopNT-in 3.038 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.35, 141.07 APE9-dihe-in -143.22, 147.19 APE8-dihe-in -79.09, 97.45 APE8-rot-na 29.19 APE67-dihe-in -72.55, -20.06 -64.96, -33.09 APE12-dist-na 12.459 APE11-dist-na 9.877 APE10-dist-na 10.932 APE9-dist-in 6.768 None None None XRAY 2.651 0.186 0.217 A 328 288 12 0 0 4 [[712, 970]] 1.0 5fed Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7T4IA P00533 697 1017 1210.0 R28:2500 Type1 Active DFGin 6.176 15.419 BLAminus -134.59, -174.82 67.2, 83.56 -99.26, 19.99 299.76, 93.96 -46.8, -37.05 in-in in 8.675 Saltbr-in 2.804 HRD-in -73.31, -54.28 79.02, 0.69 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.0, 142.26 APE9-dihe-in -143.46, 152.77 APE8-dihe-in -85.15, 103.65 APE8-rot-na 32.16 APE67-dihe-in -74.65, -13.42 -69.82, -40.13 APE12-dist-na 12.549 APE11-dist-na 9.892 APE10-dist-na 10.85 APE9-dist-in 7.003 None None None XRAY 2.61 0.184 0.238 A 328 309 0 0 0 0 [[712, 970]] 1.0 7t4i Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4LI5A P00533 696 1020 1210.0 1WY:61101 Type1 Active DFGin 6.026 14.162 BLAminus -131.0, -176.73 65.77, 86.42 -104.38, 23.51 292.36, 92.5 -61.36, -28.57 in-in in 8.377 Saltbr-in 3.261 HRD-in -74.32, -49.54 74.09, -0.72 in-in-in SNCiii in-in ActLoopNT-in 2.918 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.05, 130.94 APE9-dihe-in -140.59, 141.96 APE8-dihe-in -66.3, 105.4 APE8-rot-na 342.58 APE67-dihe-in -77.77, -5.8 -61.35, -32.71 APE12-dist-na 12.142 APE11-dist-na 9.774 APE10-dist-na 10.382 APE9-dist-in 6.112 None None None XRAY 2.64 0.166 0.203 A 328 303 0 0 0 0 [[712, 970]] 1.0 4li5 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4I23A P00533 695 1018 1210.0 1C9:9001 Type1 Active DFGin 5.831 14.799 BLAminus -136.95, -174.22 62.68, 72.46 -94.9, 21.34 301.95, 95.75 -66.8, 22.74 in-in in 8.738 Saltbr-in 2.785 HRD-in -56.19, -44.26 64.75, 4.02 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.49, 132.64 APE9-dihe-in -135.81, 134.69 APE8-dihe-in -75.01, 107.02 APE8-rot-na 32.25 APE67-dihe-in -70.4, -28.14 -84.36, -22.76 APE12-dist-na 12.219 APE11-dist-na 10.388 APE10-dist-na 10.927 APE9-dist-in 6.774 None None None XRAY 2.8 0.229 0.279 A 329 304 5 0 0 0 [[712, 970]] 1.0 4i23 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5UGBA P00533 695 1018 1210.0 8BM:9001 Type1 Active DFGin 5.835 14.651 BLAminus -134.46, -178.88 69.24, 78.86 -98.25, 26.83 301.46, 96.9 -60.13, -9.04 in-in in 8.798 Saltbr-in 2.83 HRD-in -79.7, -47.46 72.87, -2.89 in-in-in SNCiii in-in ActLoopNT-in 2.867 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.56, 109.91 APE9-dihe-in -106.09, 146.18 APE8-dihe-in -73.44, 111.13 APE8-rot-na 29.02 APE67-dihe-in -77.49, -5.29 -73.0, -29.08 APE12-dist-na 12.245 APE11-dist-na 10.361 APE10-dist-na 11.122 APE9-dist-in 6.287 None None None XRAY 2.53 0.216 0.251 A 329 307 2 0 0 0 [[712, 970]] 1.0 5ugb Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7AEIA P00533 697 1018 1210.0 R85:1101 Type1 Active DFGin 6.208 14.792 BLAminus -126.01, -169.45 55.16, 81.89 -96.08, 14.73 291.11, 108.26 -69.45, 12.21 in-in in 8.768 Saltbr-in 3.443 HRD-in -60.05, -48.12 65.53, 1.77 in-in-in SNCiii in-in ActLoopNT-in 2.818 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -60.35, 121.7 APE9-dihe-in -129.58, 132.22 APE8-dihe-in -78.63, 102.11 APE8-rot-na 17.26 APE67-dihe-in -70.55, -9.57 -65.82, -33.23 APE12-dist-na 11.817 APE11-dist-na 10.052 APE10-dist-na 10.814 APE9-dist-in 6.719 None None None XRAY 2.65 0.196 0.234 A 329 315 2 0 0 0 [[712, 970]] 1.0 7aei Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9FZRA P00533 696 1019 1210.0 A1IHC:1101 Type1 Active DFGin 5.859 14.582 BLAminus -136.77, -162.41 64.21, 71.65 -93.43, 21.81 293.45, 102.18 -73.25, -5.87 in-in in 8.367 Saltbr-in 2.902 HRD-in -77.53, -49.65 72.64, -0.27 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.76, 132.8 APE9-dihe-in -127.36, 148.53 APE8-dihe-in -82.36, 72.78 APE8-rot-na 39.77 APE67-dihe-in -76.27, 2.11 -52.52, -42.1 APE12-dist-na 11.814 APE11-dist-na 10.176 APE10-dist-na 10.925 APE9-dist-in 7.052 None None None XRAY 1.991 0.189 0.233 A 329 324 0 0 0 0 [[712, 970]] 1.0 9fzr Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9FZSA P00533 696 1019 1210.0 A1IHD:1101 Type1 Active DFGin 5.721 14.664 BLAminus -136.17, -166.26 65.85, 70.42 -92.09, 18.91 293.3, 103.28 -70.03, -3.34 in-in in 8.381 Saltbr-in 2.903 HRD-in -74.04, -50.49 73.77, -1.21 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.95, 138.36 APE9-dihe-in -133.01, 146.9 APE8-dihe-in -83.18, 78.47 APE8-rot-na 33.99 APE67-dihe-in -74.96, -5.94 -62.28, -35.01 APE12-dist-na 12.075 APE11-dist-na 10.146 APE10-dist-na 10.869 APE9-dist-in 7.081 None None None XRAY 2.121 0.196 0.237 A 329 324 0 0 0 0 [[712, 970]] 1.0 9fzs Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4WKQA P00533 696 1020 1210.0 IRE:61101 Type1 Active DFGin 5.87 14.27 BLAminus -136.93, -167.98 56.09, 82.01 -98.49, 20.74 290.51, 104.81 -58.21, -26.99 in-in in 8.496 Saltbr-in 2.777 HRD-in -72.77, -46.24 69.32, 1.48 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.97, 133.87 APE9-dihe-in -143.86, 136.85 APE8-dihe-in -65.0, 99.96 APE8-rot-na 331.29 APE67-dihe-in -71.38, -8.88 -57.65, -38.22 APE12-dist-na 12.229 APE11-dist-na 9.741 APE10-dist-na 10.136 APE9-dist-in 6.148 None None CSX797 XRAY 1.85 0.196 0.225 A 330 295 8 0 0 0 [[712, 970]] 1.0 4wkq Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8SC7A P00533 696 1019 1210.0 D0D:61103 Type1 Active DFGin 5.703 14.779 BLAminus -139.2, -168.32 65.12, 69.36 -88.74, 17.57 294.89, 100.25 -60.65, -23.49 in-in in 8.53 Saltbr-in 2.694 HRD-in -75.7, -43.54 68.68, -2.69 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.67, 135.95 APE9-dihe-in -137.41, 139.41 APE8-dihe-in -85.95, 80.26 APE8-rot-na 35.46 APE67-dihe-in -72.73, -8.0 -55.77, -34.53 APE12-dist-na 12.176 APE11-dist-na 9.922 APE10-dist-na 9.889 APE9-dist-in 6.936 None None None XRAY 1.984 0.187 0.216 A 330 324 0 0 0 0 [[712, 970]] 1.0 8sc7 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9KL4A P00533 696 1019 1210.0 A1L53:1101 Type1 Active DFGin 5.882 14.873 BLAminus -137.95, -173.96 67.15, 83.4 -96.91, 17.41 294.77, 100.38 -52.64, -41.23 in-in in 8.615 Saltbr-in 3.086 HRD-in -70.73, -50.16 70.67, 8.63 in-in-in SNCiii in-in ActLoopNT-in 2.867 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.29, 144.18 APE9-dihe-in -146.46, 153.32 APE8-dihe-in -90.55, 99.64 APE8-rot-na 31.82 APE67-dihe-in -68.73, -13.99 -62.45, -40.55 APE12-dist-na 11.663 APE11-dist-na 9.882 APE10-dist-na 10.641 APE9-dist-in 6.875 None None None XRAY 2.32 0.189 0.238 A 330 313 0 0 0 0 [[712, 970]] 1.0 9kl4 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5CAVA P00533 697 1020 1210.0 4ZQ:1101 Type1 Active DFGin 5.728 15.178 BLAminus -144.14, -171.01 62.22, 83.13 -95.58, 29.43 294.47, 99.62 -62.26, -29.69 in-in in 8.891 Saltbr-in 2.886 HRD-in -61.83, -49.9 69.79, -4.81 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.05, 121.92 APE9-dihe-in -127.65, 141.47 APE8-dihe-in -77.45, 96.85 APE8-rot-na 26.93 APE67-dihe-in -72.16, -12.12 -60.35, -39.9 APE12-dist-na 11.975 APE11-dist-na 10.062 APE10-dist-na 10.409 APE9-dist-in 6.468 None None None XRAY 2.73 0.198 0.231 A 331 306 0 0 0 0 [[712, 970]] 1.0 5cav Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5EM8A P00533 696 1018 1210.0 5Q4:1101 Type1 Active DFGin 6.262 14.789 BLAminus -136.52, -174.1 61.67, 87.27 -100.82, 25.52 292.95, 95.53 -58.03, -32.6 in-in in 8.649 Saltbr-in 2.943 HRD-in -59.6, -53.0 72.37, -0.6 in-in-in SNCiii in-in ActLoopNT-in 2.806 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.98, 123.11 APE9-dihe-in -124.21, 147.07 APE8-dihe-in -85.24, 91.96 APE8-rot-na 26.09 APE67-dihe-in -68.99, -10.46 -52.36, -42.63 APE12-dist-na 11.849 APE11-dist-na 9.73 APE10-dist-na 10.702 APE9-dist-in 6.636 None None None XRAY 2.8 0.191 0.229 A 331 303 5 0 0 2 [[712, 970]] 1.0 5em8 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7KXZA P00533 696 1017 1210.0 XA4:1102 Type1 Active DFGin 5.92 14.588 BLAminus -136.31, -168.83 60.33, 83.14 -97.98, 27.21 293.22, 85.75 -65.75, -18.76 in-in in 8.543 Saltbr-in 2.474 HRD-in -75.7, -47.88 69.93, 6.54 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.33, 134.32 APE9-dihe-in -142.53, 141.1 APE8-dihe-in -75.24, 95.2 APE8-rot-na 20.58 APE67-dihe-in -77.94, 1.68 -59.99, -41.31 APE12-dist-na 12.252 APE11-dist-na 10.145 APE10-dist-na 10.533 APE9-dist-in 6.649 None None None XRAY 2.4 0.191 0.219 A 331 299 4 0 0 0 [[712, 970]] 1.0 7kxz Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7U99A P00533 695 1018 1210.0 M0R:61101 Type1 Active DFGin 5.755 14.716 BLAminus -136.96, -164.91 59.51, 80.36 -97.33, 25.45 292.89, 108.43 -72.5, -16.29 in-in in 8.574 Saltbr-in 2.775 HRD-in -72.48, -53.99 74.78, 0.57 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.44, 137.22 APE9-dihe-in -138.33, 149.04 APE8-dihe-in -75.25, 92.8 APE8-rot-na 11.47 APE67-dihe-in -78.7, 1.11 -63.71, -39.94 APE12-dist-na 11.835 APE11-dist-na 10.072 APE10-dist-na 10.731 APE9-dist-in 6.481 None None None XRAY 2.5 0.189 0.214 A 331 303 0 0 0 0 [[712, 970]] 1.0 7u99 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8F1HA P00533 697 1018 1210.0 X9H:1101 Type1 Active DFGin 5.457 14.887 BLAminus -145.15, -171.29 62.16, 94.67 -110.53, 25.16 293.79, 96.97 -66.2, -17.77 in-in in 9.35 Saltbr-in 2.996 HRD-in -63.65, -43.09 65.18, 5.08 in-in-in SNCiii in-in ActLoopNT-in 2.979 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -53.29, 129.01 APE9-dihe-in -138.63, 144.06 APE8-dihe-in -72.09, 88.56 APE8-rot-na 27.99 APE67-dihe-in -71.49, 2.29 -62.91, -34.63 APE12-dist-na 12.2 APE11-dist-na 10.244 APE10-dist-na 10.519 APE9-dist-in 6.589 None None None XRAY 2.8 0.186 0.212 A 331 307 0 0 0 0 [[712, 970]] 1.0 8f1h Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8F1XA P00533 696 1018 1210.0 R28:1101 Type1 Active DFGin 5.983 15.01 BLAminus -136.15, -173.95 61.32, 87.85 -107.98, 33.07 295.84, 87.53 -69.26, -26.04 in-in in 8.386 Saltbr-in 2.835 HRD-in -75.88, -47.81 70.31, 4.02 in-in-in SNCiii in-in ActLoopNT-in 2.807 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.75, 114.5 APE9-dihe-in -126.56, 132.44 APE8-dihe-in -61.97, 98.31 APE8-rot-na 23.91 APE67-dihe-in -74.89, 2.26 -62.79, -43.67 APE12-dist-na 12.267 APE11-dist-na 9.833 APE10-dist-na 10.674 APE9-dist-in 6.627 None None None XRAY 2.3 0.205 0.226 A 331 317 3 0 0 0 [[712, 970]] 1.0 8f1x Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8F1YA P00533 696 1019 1210.0 R2E:1101 Type1 Active DFGin 5.893 15.215 BLAminus -140.27, -173.76 62.92, 82.37 -103.43, 34.41 296.38, 97.61 -65.28, -35.48 in-in in 8.767 Saltbr-in 3.103 HRD-in -72.9, -46.1 67.76, 1.27 in-in-in SNCiii in-in ActLoopNT-in 3.077 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -54.27, 107.83 APE9-dihe-in -116.34, 152.7 APE8-dihe-in -84.23, 88.9 APE8-rot-na 19.13 APE67-dihe-in -72.32, -8.46 -55.36, -45.52 APE12-dist-na 11.785 APE11-dist-na 9.572 APE10-dist-na 10.376 APE9-dist-in 6.803 None None None XRAY 2.75 0.206 0.228 A 331 293 9 0 0 3 [[712, 970]] 1.0 8f1y Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8TJLA P00533 696 1019 1210.0 HZ6:1101 Type1 Active DFGin 5.797 15.097 BLAminus -141.02, -174.36 63.37, 90.63 -108.66, 26.85 295.65, 94.46 -59.59, -43.72 in-in in 8.964 Saltbr-in 2.83 HRD-in -75.09, -44.89 64.25, 3.96 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -59.81, 122.21 APE9-dihe-in -122.18, 149.91 APE8-dihe-in -79.84, 97.02 APE8-rot-na 30.38 APE67-dihe-in -74.86, -3.8 -67.12, -38.73 APE12-dist-na 11.348 APE11-dist-na 10.353 APE10-dist-na 10.469 APE9-dist-in 6.649 None None None XRAY 2.7 0.198 0.232 A 331 306 4 0 0 2 [[712, 970]] 1.0 8tjl Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8HV2A P00533 697 1019 1210.0 MWU:1101 Type1 Active DFGin 6.04 15.435 BLAminus -139.32, -173.88 59.04, 78.19 -91.93, 13.59 293.33, 98.36 -42.59, -32.3 in-in in 8.531 Saltbr-in 3.03 HRD-in -71.07, -46.84 65.82, -1.03 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.7, 109.65 APE9-dihe-in -131.83, 146.16 APE8-dihe-in -84.8, 103.81 APE8-rot-na 36.12 APE67-dihe-in -74.37, -12.04 -73.53, -33.32 APE12-dist-na 11.64 APE11-dist-na 10.242 APE10-dist-na 11.472 APE9-dist-in 6.978 None None None XRAY 2.8 0.179 0.216 A 331 299 8 0 0 5 [[712, 970]] 1.0 8hv2 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7AEMA P00533 695 1018 1210.0 6GY:1101 Type1 Active DFGin 6.131 14.377 BLAminus -127.32, -173.27 58.22, 82.35 -96.27, 28.52 299.39, 108.91 -62.1, -37.1 in-in in 8.638 Saltbr-in 2.804 HRD-in -54.09, -43.45 61.95, 3.78 in-in-in SNCiii in-in ActLoopNT-in 3.047 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.52, 113.41 APE9-dihe-in -117.42, 140.01 APE8-dihe-in -72.37, 110.57 APE8-rot-na 353.82 APE67-dihe-in -65.05, -21.43 -66.41, -39.04 APE12-dist-na 12.28 APE11-dist-na 9.798 APE10-dist-na 10.67 APE9-dist-in 6.31 None None None XRAY 2.65 0.199 0.221 A 346 312 2 0 0 0 [[712, 970]] 1.0 7aem Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2ITPA P00533 697 1018 1210.0 AEE:2019 Type1 Active DFGin 5.862 14.646 BLAminus -129.98, -162.9 59.16, 79.47 -92.61, 9.17 298.14, 95.91 -39.72, -19.96 in-in in 8.075 Saltbr-in 2.967 HRD-in -64.35, -49.17 69.51, 1.0 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.58, 125.89 APE9-dihe-in -133.11, 143.15 APE8-dihe-in -86.75, 111.19 APE8-rot-na 34.96 APE67-dihe-in -68.3, -8.64 -72.28, -40.19 APE12-dist-na 11.875 APE11-dist-na 10.343 APE10-dist-na 11.0 APE9-dist-in 6.7 G719S None None XRAY 2.74 0.2 0.255 A 327 305 0 0 0 0 [[712, 970]] 1.0 2itp Homo sapiens TYR_EGFR_HUMAN TYR 9.6e-87 296.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2ITQA P00533 697 1018 1210.0 ITQ:2019 Type1 Active DFGin 6.078 15.164 BLAminus -134.28, -154.87 40.05, 86.95 -97.26, 14.78 286.7, 93.76 -49.66, -18.35 in-in in 8.212 Saltbr-in 2.496 HRD-in -68.58, -43.07 56.84, -0.76 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.75, 129.22 APE9-dihe-in -146.28, 133.97 APE8-dihe-in -72.77, 108.98 APE8-rot-na 28.27 APE67-dihe-in -74.85, -6.78 -74.35, -36.29 APE12-dist-na 12.367 APE11-dist-na 10.751 APE10-dist-na 10.745 APE9-dist-in 6.881 G719S None None XRAY 2.68 0.2 0.263 A 327 300 0 0 0 0 [[712, 970]] 1.0 2itq Homo sapiens TYR_EGFR_HUMAN TYR 9.6e-87 296.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6S9DA P00533 696 1017 1210.0 L3Z:61101 Type1 Active DFGin 5.692 14.454 BLAminus -145.84, -174.05 67.63, 80.79 -98.28, 29.08 296.6, 89.58 -65.8, -31.86 in-in in 8.44 Saltbr-in 2.714 HRD-in -67.01, -49.55 68.04, 12.84 in-in-in SNCiii in-in ActLoopNT-in 2.709 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.59, 131.77 APE9-dihe-in -121.94, 151.66 APE8-dihe-in -82.25, 75.56 APE8-rot-na 33.03 APE67-dihe-in -75.15, -10.02 -57.2, -40.45 APE12-dist-na 999.0 APE11-dist-na 11.155 APE10-dist-na 11.656 APE9-dist-in 7.189 T790M,L858R,E865A,E866A,K867A None None XRAY 2.67 0.195 0.224 A 329 298 13 0 0 11 [[712, 970]] 1.0 6s9d Homo sapiens TYR_EGFR_HUMAN TYR 4.5e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5HIBA P00533 696 1018 1210.0 63M:1101 Type1 Active DFGin 6.281 14.551 BLAminus -131.07, 178.91 58.54, 91.9 -106.97, 30.42 293.82, 89.04 -65.69, -27.27 in-in in 8.344 Saltbr-in 2.794 HRD-in -59.32, -46.04 66.52, -1.89 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.8, 112.15 APE9-dihe-in -114.46, 138.28 APE8-dihe-in -86.32, 78.33 APE8-rot-na 21.67 APE67-dihe-in -70.2, -2.29 -48.79, -44.91 APE12-dist-na 12.506 APE11-dist-na 11.364 APE10-dist-na 10.772 APE9-dist-in 7.181 T790M,L858R,E865A,E866A,K867A None None XRAY 2.85 0.197 0.239 A 331 314 5 0 0 5 [[712, 970]] 1.0 5hib Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4LQMA P00533 697 1019 1210.0 DJK:1101 Type1 Active DFGin 5.979 14.54 BLAminus -148.3, -172.91 62.11, 72.19 -94.6, 21.41 296.71, 99.46 -60.17, -37.69 in-in in 8.219 Saltbr-in 2.831 HRD-in -68.88, -49.63 72.39, 3.25 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.81, 131.0 APE9-dihe-in -102.62, 141.96 APE8-dihe-in -82.36, 88.32 APE8-rot-na 26.08 APE67-dihe-in -70.52, -7.71 -65.57, -41.89 APE12-dist-na 999.0 APE11-dist-na 11.501 APE10-dist-na 12.101 APE9-dist-in 7.518 L858R None None XRAY 2.5 0.187 0.228 A 331 305 10 0 0 7 [[712, 970]] 1.0 4lqm Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7LGSA P00533 702 984 1210.0 Q6K:61101 Type1 Active DFGin 5.798 13.848 BLAminus -148.14, -179.86 66.83, 93.39 -109.24, 25.55 296.83, 82.02 -45.71, -51.38 in-in in 8.254 Saltbr-in 2.914 HRD-in -61.85, -36.93 72.75, -6.16 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.14, 118.29 APE9-dihe-in -124.18, 152.07 APE8-dihe-in -87.87, 98.71 APE8-rot-na 33.29 APE67-dihe-in -76.07, 20.02 -59.01, -47.71 APE12-dist-na 10.735 APE11-dist-na 9.717 APE10-dist-na 10.441 APE9-dist-in 6.735 V948R None None XRAY 3.1 0.241 0.305 A 331 280 3 0 0 0 [[712, 970]] 1.0 7lgs Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7LGSB P00533 702 984 1210.0 Q6K:62703 Type1 Active DFGin 6.065 14.132 BLAminus -143.64, 174.55 75.07, 86.01 -103.95, 23.76 297.26, 76.2 -47.19, -46.41 in-in in 8.489 Saltbr-in 2.925 HRD-in -70.84, -32.42 56.54, 26.28 in-in-in SNCiii in-in ActLoopNT-in 2.803 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.24, 133.4 APE9-dihe-in -137.17, 157.48 APE8-dihe-in -85.36, 106.29 APE8-rot-na 33.1 APE67-dihe-in -76.15, 7.94 -70.75, -39.01 APE12-dist-na 11.907 APE11-dist-na 9.426 APE10-dist-na 10.275 APE9-dist-in 6.571 V948R None None XRAY 3.1 0.241 0.305 B 331 283 0 0 0 0 [[712, 970]] 1.0 7lgs Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7LGSC P00533 701 984 1210.0 Q6K:61101 Type1 Active DFGin 5.788 13.836 BLAminus -144.73, 172.67 64.73, 92.38 -102.97, 22.8 303.24, 82.51 -50.29, -34.49 in-in in 8.064 Saltbr-in 3.457 HRD-in -60.12, -39.38 78.78, -23.89 in-in-in SNCiii in-in ActLoopNT-in 3.202 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -145.58, 117.71 APE9-dihe-in -124.38, 146.08 APE8-dihe-in -62.99, 124.66 APE8-rot-na 21.56 APE67-dihe-in -104.68, 1.44 -87.08, -8.44 APE12-dist-na 11.582 APE11-dist-na 9.289 APE10-dist-na 9.921 APE9-dist-in 6.458 V948R None None XRAY 3.1 0.241 0.305 C 331 280 4 0 0 0 [[712, 970]] 1.0 7lgs Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7LGSD P00533 701 984 1210.0 Q6K:62500 Type1 Active DFGin 5.717 14.024 BLAminus -133.47, 170.68 74.78, 90.52 -109.47, 24.05 298.1, 77.01 -64.19, -15.34 in-in in 8.201 Saltbr-in 2.786 HRD-in -55.31, -49.72 74.8, 6.32 in-in-in SNCiii in-in ActLoopNT-in 2.837 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.9, 130.33 APE9-dihe-in -138.85, 149.74 APE8-dihe-in -80.14, 110.14 APE8-rot-na 30.64 APE67-dihe-in -83.2, -1.33 -71.86, -29.25 APE12-dist-na 11.726 APE11-dist-na 9.543 APE10-dist-na 10.278 APE9-dist-in 6.353 V948R None None XRAY 3.1 0.241 0.305 D 331 276 8 0 0 0 [[712, 970]] 1.0 7lgs Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7T4JB P00533 701 984 1210.0 R28:61101 Type1 Active DFGin 6.154 14.095 BLAminus -144.13, 179.52 58.61, 83.85 -92.13, 21.8 294.24, 75.73 -54.65, -26.76 in-in in 7.881 Saltbr-in 2.775 HRD-in -69.57, -54.49 84.7, -3.58 in-in-in SNCiii in-in ActLoopNT-in 2.806 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.5, 142.26 APE9-dihe-in -155.99, 150.11 APE8-dihe-in -82.77, 101.36 APE8-rot-na 36.83 APE67-dihe-in -75.7, -4.6 -67.21, -37.02 APE12-dist-na 11.913 APE11-dist-na 10.71 APE10-dist-na 10.255 APE9-dist-in 6.477 V948R None None XRAY 2.2 0.227 0.278 B 331 275 9 0 0 0 [[712, 970]] 1.0 7t4j Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4LRMA P00533 696 999 1210.0 YUN:61101 Type1 Active DFGin 4.93 14.141 BLAminus -158.6, -179.81 59.5, 67.69 -73.3, -10.6 304.95, 80.93 -43.1, -43.98 in-in in 8.525 Saltbr-in 2.25 HRD-in -63.46, -47.09 80.09, -2.56 in-in-in SNCiii in-in ActLoopNT-in 3.48 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.95, 131.0 APE9-dihe-in -142.36, 158.24 APE8-dihe-in -79.28, 92.61 APE8-rot-na 26.9 APE67-dihe-in -59.89, -28.15 -57.58, -49.17 APE12-dist-na 9.439 APE11-dist-na 11.082 APE10-dist-na 9.688 APE9-dist-in 7.132 None None None XRAY 3.526 0.227 0.264 A 334 304 0 0 0 0 [[712, 970]] 1.0 4lrm Homo sapiens TYR_EGFR_HUMAN TYR 1.7e-85 292.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4LRMB P00533 695 984 1210.0 YUN:61101 Type1 Active DFGin 5.532 14.623 BLAminus -142.14, -169.88 61.38, 66.02 -84.65, 8.68 301.37, 83.75 -51.1, -43.11 in-in in 8.174 Saltbr-in 2.299 HRD-in -63.69, -44.58 74.58, 1.29 in-in-in SNCiii in-in ActLoopNT-in 3.42 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.16, 130.29 APE9-dihe-in -170.64, 141.47 APE8-dihe-in -73.49, 101.45 APE8-rot-na 22.26 APE67-dihe-in -63.2, -7.11 -64.86, -46.08 APE12-dist-na 10.44 APE11-dist-na 11.621 APE10-dist-na 9.395 APE9-dist-in 6.862 None None None XRAY 3.526 0.227 0.264 B 334 290 0 0 0 0 [[712, 970]] 1.0 4lrm Homo sapiens TYR_EGFR_HUMAN TYR 1.7e-85 292.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4LRMC P00533 694 983 1210.0 YUN:61101 Type1 Active DFGin 5.508 14.779 BLAminus -160.48, -176.43 59.92, 67.08 -79.93, -1.69 283.78, 100.07 -59.01, -39.57 in-in in 8.9 Saltbr-in 3.071 HRD-in -63.5, -47.73 78.4, -4.25 in-in-in SNCiii in-in ActLoopNT-in 3.24 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -126.48, 145.03 APE9-dihe-in -149.11, 167.52 APE8-dihe-in -81.81, 92.2 APE8-rot-na 26.63 APE67-dihe-in -60.5, -24.4 -61.07, -44.78 APE12-dist-na 10.454 APE11-dist-na 12.259 APE10-dist-na 11.083 APE9-dist-in 7.237 None None None XRAY 3.526 0.227 0.264 C 334 290 0 0 0 0 [[712, 970]] 1.0 4lrm Homo sapiens TYR_EGFR_HUMAN TYR 1.7e-85 292.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4LRMD P00533 696 981 1210.0 YUN:61101 Type1 Active DFGin 5.712 15.251 BLAminus -148.37, -162.17 52.48, 44.96 -64.79, -16.2 243.39, 79.15 -40.26, -53.82 in-in in 8.723 Saltbr-in 3.075 HRD-in -62.93, -45.84 76.67, -2.7 in-in-in SNCiii in-in ActLoopNT-in 3.103 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.87, 124.7 APE9-dihe-in -148.33, 129.49 APE8-dihe-in -84.5, 68.54 APE8-rot-na 31.24 APE67-dihe-in -68.57, -19.39 -40.54, -45.59 APE12-dist-na 9.638 APE11-dist-na 11.365 APE10-dist-na 8.404 APE9-dist-in 7.285 None None None XRAY 3.526 0.227 0.264 D 334 286 0 0 0 0 [[712, 970]] 1.0 4lrm Homo sapiens TYR_EGFR_HUMAN TYR 1.7e-85 292.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4LRME P00533 697 983 1210.0 YUN:61101 Type1 Active DFGin 5.122 15.128 BLAminus -149.12, 177.76 56.26, 51.42 -60.22, -36.0 278.23, 76.29 -54.0, 140.36 in-in in 8.548 Saltbr-in 2.983 HRD-in -64.42, -45.57 82.92, -8.54 in-in-in SNCiii in-in ActLoopNT-in 3.08 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -59.92, 140.02 APE9-dihe-in -130.51, 156.61 APE8-dihe-in -89.68, 108.31 APE8-rot-na 37.48 APE67-dihe-in -56.1, -15.47 -64.45, -45.1 APE12-dist-na 11.529 APE11-dist-na 9.116 APE10-dist-na 10.778 APE9-dist-in 6.782 None None None XRAY 3.526 0.227 0.264 E 334 287 0 0 0 0 [[712, 970]] 1.0 4lrm Homo sapiens TYR_EGFR_HUMAN TYR 1.7e-85 292.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9U8CB P00533 696 986 1210.0 A1L8T:61101 Type1 Active DFGin 5.714 14.383 BLAminus -153.52, -165.36 55.2, 60.65 -75.31, 21.07 288.54, 57.13 -53.37, -43.45 in-in in 8.847 Saltbr-in 3.157 HRD-in -114.61, -29.69 63.56, -60.39 in-in-in SNCiii in-in ActLoopNT-in 3.325 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.43, 125.24 APE9-dihe-in -148.34, 150.87 APE8-dihe-in -80.56, 88.11 APE8-rot-na 26.92 APE67-dihe-in -64.66, -40.79 -71.91, -41.96 APE12-dist-na 8.587 APE11-dist-na 11.025 APE10-dist-na 9.914 APE9-dist-in 7.586 None None None XRAY 3.5 0.275 0.3 B 338 288 3 0 0 0 [[712, 970]] 1.0 9u8c Homo sapiens TYR_EGFR_HUMAN TYR 1.7e-85 292.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6JX0A P00533 701 989 1210.0 YY3:1101,YY3:1102 Type1,Allosteric Active DFGin 5.62 14.181 BLAminus -159.3, -172.13 60.02, 72.45 -90.79, 10.95 286.73, 95.56 -60.06, -37.16 in-in in 8.691 Saltbr-in 2.665 HRD-in -72.92, -54.05 80.24, -1.58 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.1, 153.48 APE9-dihe-in -67.01, 145.59 APE8-dihe-in -63.12, 129.26 APE8-rot-na 333.49 APE67-dihe-in -73.75, -13.79 -61.59, -28.86 APE12-dist-na 9.471 APE11-dist-na 10.621 APE10-dist-na 11.287 APE9-dist-in 6.075 T790M None None XRAY 2.53 0.193 0.222 A 331 289 0 0 0 0 [[712, 970]] 1.0 6jx0 Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4G5JA P00533 696 1016 1210.0 0WN:1101,0WM:1102,0WM:1103 Type1,Allosteric,Allosteric Active DFGin 5.661 14.178 BLAminus -144.89, -175.58 68.22, 78.3 -100.61, 32.3 302.5, 82.25 -64.26, -33.66 in-in in 8.275 Saltbr-in 3.481 HRD-in -67.78, -44.08 67.8, -6.86 in-in-in SNCiii in-in ActLoopNT-in 2.692 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.07, 126.93 APE9-dihe-in -140.25, 139.74 APE8-dihe-in -66.22, 118.21 APE8-rot-na 25.54 APE67-dihe-in -77.67, -2.62 -72.63, -33.57 APE12-dist-na 11.835 APE11-dist-na 9.614 APE10-dist-na 10.111 APE9-dist-in 6.279 None None None XRAY 2.8 0.208 0.259 A 330 307 14 0 0 0 [[712, 970]] 1.0 4g5j Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8D73A P00533 703 1011 1210.0 QCR:1502 Type1.5_Back Active DFGin 5.396 14.639 BLAminus -137.39, -166.88 72.14, 68.63 -95.45, 13.53 294.58, 102.22 -51.07, -34.93 in-in in 8.48 Saltbr-in 2.899 HRD-in -72.18, -47.68 71.87, 13.91 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.59, 132.11 APE9-dihe-in -138.43, 150.74 APE8-dihe-in -80.34, 79.03 APE8-rot-na 34.01 APE67-dihe-in -74.66, -9.01 -47.69, -41.15 APE12-dist-na 12.506 APE11-dist-na 11.236 APE10-dist-na 11.277 APE9-dist-in 7.139 T790M,L858R,V948R None None XRAY 2.17 0.196 0.285 A 348 309 0 0 0 0 [[712, 970]] 1.0 8d73 Homo sapiens TYR_EGFR_HUMAN TYR 7.7e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8D73B P00533 704 1012 1210.0 QCR:1502 Type1.5_Back Active DFGin 5.395 14.65 BLAminus -137.92, -166.35 72.18, 68.71 -94.69, 12.26 295.76, 102.32 -51.71, -34.28 in-in in 8.446 Saltbr-in 2.911 HRD-in -71.23, -48.01 72.11, 12.51 in-in-in SNCiii in-in ActLoopNT-in 2.855 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.18, 131.42 APE9-dihe-in -139.31, 151.96 APE8-dihe-in -80.51, 78.64 APE8-rot-na 33.78 APE67-dihe-in -74.28, -9.24 -48.16, -40.87 APE12-dist-na 12.701 APE11-dist-na 11.364 APE10-dist-na 11.41 APE9-dist-in 7.222 T790M,L858R,V948R None None XRAY 2.17 0.196 0.285 B 348 309 0 0 0 0 [[712, 970]] 1.0 8d73 Homo sapiens TYR_EGFR_HUMAN TYR 7.7e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8D76A P00533 703 1014 1210.0 QFO:1504 Type1.5_Back Active DFGin 5.288 14.455 BLAminus -143.4, -172.03 76.83, 82.61 -101.19, 12.36 297.34, 100.87 -51.7, -27.33 in-in in 8.553 Saltbr-in 2.659 HRD-in -66.34, -53.39 73.14, 4.37 in-in-in SNCiii in-in ActLoopNT-in 2.838 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.29, 128.72 APE9-dihe-in -125.98, 143.72 APE8-dihe-in -74.29, 76.55 APE8-rot-na 33.63 APE67-dihe-in -70.33, -10.53 -49.4, -47.68 APE12-dist-na 12.407 APE11-dist-na 10.574 APE10-dist-na 11.338 APE9-dist-in 7.043 T790M,L858R,V948R None None XRAY 2.4 0.161 0.26 A 348 312 0 0 0 0 [[712, 970]] 1.0 8d76 Homo sapiens TYR_EGFR_HUMAN TYR 7.7e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8D76B P00533 702 1014 1210.0 QFO:1503 Type1.5_Back Active DFGin 5.243 14.516 BLAminus -142.04, -172.89 77.5, 81.63 -99.66, 12.37 297.26, 99.83 -52.91, -24.77 in-in in 8.564 Saltbr-in 2.654 HRD-in -65.39, -54.89 75.2, 3.17 in-in-in SNCiii in-in ActLoopNT-in 2.843 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.34, 127.65 APE9-dihe-in -127.49, 143.46 APE8-dihe-in -75.23, 77.39 APE8-rot-na 35.03 APE67-dihe-in -70.18, -10.99 -49.52, -47.15 APE12-dist-na 12.473 APE11-dist-na 10.719 APE10-dist-na 11.188 APE9-dist-in 7.049 T790M,L858R,V948R None None XRAY 2.4 0.161 0.26 B 348 313 0 0 0 0 [[712, 970]] 1.0 8d76 Homo sapiens TYR_EGFR_HUMAN TYR 7.7e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9GL9A P00533 696 1019 1210.0 A1IMT:61103 Type1.5_Back Active DFGin 6.134 14.351 BLAminus -126.96, -175.87 60.02, 86.56 -97.41, 25.27 289.91, 91.21 -60.54, -33.98 in-in in 8.369 Saltbr-in 2.935 HRD-in -68.5, -49.91 70.75, -1.83 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.17, 127.77 APE9-dihe-in -129.15, 139.26 APE8-dihe-in -73.46, 89.68 APE8-rot-na 31.97 APE67-dihe-in -69.08, -6.41 -52.73, -42.79 APE12-dist-na 11.768 APE11-dist-na 10.048 APE10-dist-na 10.634 APE9-dist-in 6.686 None None None XRAY 2.147 0.198 0.213 A 330 313 6 0 0 4 [[712, 970]] 1.0 9gl9 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9FRDA P00533 696 1019 1210.0 A1IEZ:61102 Type1.5_Back Active DFGin 6.155 14.189 BLAminus -125.51, -178.61 65.62, 88.15 -97.54, 20.94 286.3, 83.68 -59.21, -29.23 in-in in 8.202 Saltbr-in 2.761 HRD-in -72.5, -48.72 73.37, 1.71 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.9, 136.61 APE9-dihe-in -149.53, 130.81 APE8-dihe-in -64.36, 102.72 APE8-rot-na 338.2 APE67-dihe-in -74.18, -9.57 -63.44, -34.46 APE12-dist-na 12.068 APE11-dist-na 9.726 APE10-dist-na 10.278 APE9-dist-in 6.179 None None None XRAY 2.06 0.169 0.197 A 330 306 0 0 0 0 [[712, 970]] 1.0 9frd Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9GI9A P00533 696 1018 1210.0 A1ILZ:1101 Type1.5_Back Active DFGin 5.846 13.826 BLAminus -132.78, -179.57 58.09, 96.13 -103.87, 37.89 296.85, 81.49 -65.94, -46.82 in-in in 7.886 Saltbr-in 2.987 HRD-in -78.91, -43.62 64.99, 17.27 in-in-in SNCiii in-in ActLoopNT-in 2.765 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.67, 120.08 APE9-dihe-in -139.61, 156.88 APE8-dihe-in -87.5, 103.35 APE8-rot-na 33.87 APE67-dihe-in -65.81, -24.28 -64.29, -41.89 APE12-dist-na 9.521 APE11-dist-na 10.15 APE10-dist-na 10.652 APE9-dist-in 6.635 None None None XRAY 3.12 0.192 0.248 A 330 308 7 0 0 7 [[712, 970]] 1.0 9gi9 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8F1ZA P00533 695 1018 1210.0 X9B:61101 Type1.5_Back Active DFGin 6.21 14.364 BLAminus -134.27, -179.34 59.56, 91.21 -108.92, 34.22 293.79, 82.15 -70.49, -26.69 in-in in 8.341 Saltbr-in 2.99 HRD-in -74.18, -45.61 69.12, 3.39 in-in-in SNCiii in-in ActLoopNT-in 2.958 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.23, 123.8 APE9-dihe-in -133.02, 144.23 APE8-dihe-in -69.28, 89.44 APE8-rot-na 26.79 APE67-dihe-in -74.18, 0.3 -61.08, -41.42 APE12-dist-na 12.229 APE11-dist-na 10.143 APE10-dist-na 10.615 APE9-dist-in 6.502 None None None XRAY 2.4 0.193 0.212 A 331 309 3 0 0 0 [[712, 970]] 1.0 8f1z Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9QXNAAA P00533 696 1019 1210.0 A1JBI:61107 Type1.5_Back Active DFGin 6.174 14.286 BLAminus -130.22, -177.04 61.75, 91.16 -101.11, 22.36 284.94, 80.33 -60.14, -31.4 in-in in 8.367 Saltbr-in 2.953 HRD-in -68.76, -48.96 69.89, 3.72 in-in-in SNCiii in-in ActLoopNT-in 2.791 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.32, 133.52 APE9-dihe-in -138.05, 143.6 APE8-dihe-in -59.33, 99.88 APE8-rot-na 336.87 APE67-dihe-in -75.29, -7.57 -63.05, -36.41 APE12-dist-na 12.534 APE11-dist-na 9.376 APE10-dist-na 10.271 APE9-dist-in 6.122 None None None XRAY 2.142 0.158 0.21 AAA 346 322 2 0 0 0 [[712, 970]] 1.0 9qxn Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9DF2A P00533 701 1004 1210.0 A1IMS:61101 Type1.5_Back Active DFGin 6.178 13.819 BLAminus -138.62, 178.98 67.62, 97.78 -114.22, 32.37 297.28, 88.95 -71.37, -22.63 in-in in 8.265 Saltbr-in 2.687 HRD-in -67.48, -51.99 72.72, 4.57 in-in-in SNCiii in-in ActLoopNT-in 2.943 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.21, 135.87 APE9-dihe-in -144.97, 152.75 APE8-dihe-in -81.03, 89.7 APE8-rot-na 33.51 APE67-dihe-in -75.91, -6.34 -54.41, -42.45 APE12-dist-na 12.562 APE11-dist-na 9.691 APE10-dist-na 10.529 APE9-dist-in 6.348 V948R None None XRAY 2.5 0.199 0.245 A 333 299 5 0 0 0 [[712, 970]] 1.0 9df2 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-86 293.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9DF3A P00533 701 1022 1210.0 A1IMS:61101 Type1.5_Back Active DFGin 6.12 14.079 BLAminus -133.91, -175.29 63.5, 92.21 -102.95, 27.03 288.2, 89.06 -60.61, -32.74 in-in in 8.449 Saltbr-in 2.779 HRD-in -72.11, -45.74 69.04, 1.04 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.71, 138.45 APE9-dihe-in -139.83, 153.3 APE8-dihe-in -82.59, 82.51 APE8-rot-na 33.21 APE67-dihe-in -70.96, -9.32 -51.24, -45.73 APE12-dist-na 12.319 APE11-dist-na 9.465 APE10-dist-na 10.087 APE9-dist-in 6.477 V948R None None XRAY 1.68 0.172 0.2 A 333 308 4 0 0 0 [[712, 970]] 1.0 9df3 Homo sapiens TYR_EGFR_HUMAN TYR 5.8e-86 294.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9DF4A P00533 701 1019 1210.0 A1A4E:61101 Type1.5_Back Active DFGin 6.014 14.12 BLAminus -131.08, -174.63 62.32, 93.34 -104.22, 25.37 287.03, 88.41 -63.45, -29.4 in-in in 8.345 Saltbr-in 2.86 HRD-in -71.66, -49.42 73.83, 0.52 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.63, 133.65 APE9-dihe-in -141.21, 156.63 APE8-dihe-in -83.85, 81.07 APE8-rot-na 31.86 APE67-dihe-in -75.41, -6.87 -50.13, -41.68 APE12-dist-na 12.353 APE11-dist-na 9.599 APE10-dist-na 10.119 APE9-dist-in 6.495 V948R None None XRAY 1.78 0.167 0.198 A 333 305 6 0 0 0 [[712, 970]] 1.0 9df4 Homo sapiens TYR_EGFR_HUMAN TYR 5.8e-86 294.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9FQPA P00533 701 1020 1210.0 A1IEZ:62001 Type1.5_Back Active DFGin 6.174 14.223 BLAminus -134.87, 178.52 66.55, 84.7 -99.61, 41.5 293.42, 84.34 -73.42, -44.6 in-in in 8.17 Saltbr-in 2.775 HRD-in -64.23, -41.66 63.86, 1.43 in-in-in SNCiii in-in ActLoopNT-in 3.029 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.72, 136.6 APE9-dihe-in -141.56, 152.91 APE8-dihe-in -81.25, 107.18 APE8-rot-na 26.8 APE67-dihe-in -71.04, -9.55 -68.38, -41.89 APE12-dist-na 12.347 APE11-dist-na 9.299 APE10-dist-na 9.942 APE9-dist-in 6.392 V948R None None XRAY 2.495 0.244 0.275 A 338 289 7 0 0 0 [[712, 970]] 1.0 9fqp Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-85 292.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9FQSA P00533 701 1019 1210.0 A1IE0:61103 Type1.5_Back Active DFGin 6.134 14.192 BLAminus -132.91, -178.24 67.27, 86.84 -99.9, 25.54 296.52, 82.26 -59.0, -36.29 in-in in 8.617 Saltbr-in 2.89 HRD-in -69.4, -45.72 68.58, -3.7 in-in-in SNCiii in-in ActLoopNT-in 2.859 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.39, 137.92 APE9-dihe-in -140.19, 151.4 APE8-dihe-in -80.21, 88.89 APE8-rot-na 33.48 APE67-dihe-in -69.87, -7.88 -52.66, -46.03 APE12-dist-na 12.19 APE11-dist-na 9.316 APE10-dist-na 9.94 APE9-dist-in 6.4 V948R None None XRAY 1.783 0.199 0.237 A 338 302 5 0 0 0 [[712, 970]] 1.0 9fqs Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-85 292.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9GL7A P00533 702 1019 1210.0 A1IMS:62001 Type1.5_Back Active DFGin 6.154 14.08 BLAminus -129.2, -177.57 64.25, 98.42 -114.09, 41.48 295.01, 81.54 -76.03, -38.0 in-in in 8.424 Saltbr-in 2.718 HRD-in -64.01, -43.17 64.53, -6.85 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.93, 136.43 APE9-dihe-in -141.98, 154.21 APE8-dihe-in -82.6, 89.72 APE8-rot-na 31.06 APE67-dihe-in -63.89, -13.13 -49.96, -51.09 APE12-dist-na 12.393 APE11-dist-na 9.644 APE10-dist-na 10.045 APE9-dist-in 6.468 V948R None None XRAY 1.878 0.269 0.287 A 338 297 7 0 0 0 [[712, 970]] 1.0 9gl7 Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-85 292.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9GL8A P00533 701 1021 1210.0 A1IMT:61105 Type1.5_Back Active DFGin 6.109 14.327 BLAminus -129.76, -176.54 64.1, 87.88 -100.03, 29.35 290.94, 79.71 -65.82, -30.33 in-in in 8.352 Saltbr-in 2.821 HRD-in -68.18, -46.36 69.12, -2.54 in-in-in SNCiii in-in ActLoopNT-in 2.838 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.94, 136.71 APE9-dihe-in -136.26, 153.03 APE8-dihe-in -80.99, 80.94 APE8-rot-na 34.33 APE67-dihe-in -71.63, -8.89 -45.43, -47.1 APE12-dist-na 12.356 APE11-dist-na 9.463 APE10-dist-na 10.101 APE9-dist-in 6.473 V948R None None XRAY 1.632 0.189 0.224 A 338 305 5 0 0 0 [[712, 970]] 1.0 9gl8 Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-85 292.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3IKAA P00533 696 1020 1210.0 0UN:1797 Type1 Inactive DFGin 5.778 14.354 ABAminus -126.08, -29.6 -103.63, 124.88 -119.83, 2.06 294.25, 104.41 -43.93, -35.44 in-in in 9.442 Saltbr-in 3.22 HRD-in -72.42, -49.2 76.65, -5.52 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.67, 130.5 APE9-dihe-in -133.91, 150.07 APE8-dihe-in -89.48, 105.4 APE8-rot-na 32.64 APE67-dihe-in -62.96, -1.82 -70.92, -51.09 APE12-dist-na 11.082 APE11-dist-na 9.128 APE10-dist-na 9.94 APE9-dist-in 6.742 T790M None None XRAY 2.9 0.21 0.257 A 331 310 0 0 0 0 [[712, 970]] 1.0 3ika Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7ER2A P00533 697 1018 1210.0 JAU:1101 Type1 Inactive DFGin 6.121 14.754 ABAminus -129.03, -4.49 -116.2, 115.2 -116.5, 16.05 292.9, 93.99 -60.31, -21.65 in-in in 8.475 Saltbr-in 3.293 HRD-in -65.99, -41.99 69.27, -1.48 in-in-in SNCiii in-in ActLoopNT-in 2.975 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.01, 144.64 APE9-dihe-in -159.95, 159.85 APE8-dihe-in -81.99, 105.43 APE8-rot-na 34.36 APE67-dihe-in -79.1, 0.6 -66.2, -33.66 APE12-dist-na 11.353 APE11-dist-na 10.13 APE10-dist-na 10.437 APE9-dist-in 6.694 T790M,C797S None None XRAY 2.662 0.2 0.242 A 331 292 11 0 0 7 [[712, 970]] 1.0 7er2 Homo sapiens TYR_EGFR_HUMAN TYR 3.3e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9XU9A P00533 696 1020 1210.0 A1E1C:1101 Type1 Inactive DFGin 6.306 14.538 ABAminus -135.8, -11.71 -125.13, 122.43 -123.49, 11.83 295.92, 72.27 -41.05, -35.22 in-in in 8.55 Saltbr-in 2.355 HRD-in -67.87, -38.86 64.67, 9.16 in-in-in SNCiii in-in ActLoopNT-in 3.178 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.81, 167.85 APE9-dihe-in -153.48, 149.25 APE8-dihe-in -87.98, 89.05 APE8-rot-na 11.68 APE67-dihe-in -68.43, 5.48 -65.73, -47.64 APE12-dist-na 10.978 APE11-dist-na 10.272 APE10-dist-na 10.998 APE9-dist-in 7.228 T790M,C797S,L858R None None XRAY 2.84 0.235 0.294 A 331 310 0 0 0 0 [[712, 970]] 1.0 9xu9 Homo sapiens TYR_EGFR_HUMAN TYR 6.6e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8KFQA P00533 697 1018 1210.0 VUZ:1102 Type1 Inactive DFGin 6.072 14.965 ABAminus -141.13, -11.52 -105.63, 122.23 -124.79, 21.27 297.58, 119.18 -65.06, -1.37 in-in in 8.754 Saltbr-in 2.954 HRD-in -77.87, -49.16 73.66, -8.04 in-in-none SNCiin in-none ActLoopNT-in 3.086 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.18 APE8-dihe-in -86.32, 91.43 APE8-rot-na 34.26 APE67-dihe-in -70.0, -5.46 -70.66, -45.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.351 T790M,L858R None None XRAY 3.22 0.206 0.26 A 322 301 17 0 0 14 [[712, 970]] 1.0 8kfq Homo sapiens TYR_EGFR_HUMAN TYR 8e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4LL0A P00533 697 1017 1210.0 YUN:1101 Type1 Inactive DFGin 5.489 14.152 ABAminus -163.76, 69.81 -169.13, 137.16 -134.76, 14.68 278.24, 45.84 -54.76, -37.97 in-out in 9.387 Saltbr-out 3.655 HRD-in -66.16, -48.88 78.86, -10.91 out-in-none SNCoin in-none ActLoopNT-in 3.072 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.25 APE8-dihe-in -92.78, 86.64 APE8-rot-na 47.05 APE67-dihe-in -54.12, -27.22 -71.92, -41.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.806 T790M,L858R None None XRAY 4.0 0.238 0.257 A 331 291 13 0 0 13 [[712, 970]] 1.0 4ll0 Homo sapiens TYR_EGFR_HUMAN TYR 8.7e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4LL0B P00533 698 1017 1210.0 YUN:1101 Type1 Inactive DFGin 5.924 14.787 ABAminus -150.59, 21.7 -117.55, 135.66 -122.99, 27.75 263.81, 81.86 -54.7, -34.63 in-out in 9.396 Saltbr-out 3.705 HRD-in -65.09, -47.62 71.0, 0.04 out-in-none SNCoin in-none ActLoopNT-in 3.428 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.09 APE8-dihe-in -91.22, 86.34 APE8-rot-na 47.36 APE67-dihe-in -53.31, -28.09 -71.96, -41.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.712 T790M,L858R None None XRAY 4.0 0.238 0.257 B 331 281 14 0 0 14 [[712, 970]] 1.0 4ll0 Homo sapiens TYR_EGFR_HUMAN TYR 8.7e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3VJNA P00533 697 1018 1210.0 ANP:2001 ATPlike Inactive DFGin 6.07 15.553 BLAminus -140.47, -172.56 66.89, 81.42 -96.27, 22.36 285.26, 99.8 -61.68, -24.37 in-out in 8.864 Saltbr-out 4.159 HRD-in -62.92, -47.49 66.12, 0.14 out-in-in SNCoii in-in ActLoopNT-in 2.902 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.98, 116.83 APE9-dihe-in -113.71, 140.82 APE8-dihe-in -56.67, 106.47 APE8-rot-na 28.1 APE67-dihe-in -67.09, -6.37 -61.28, -43.59 APE12-dist-na 11.779 APE11-dist-na 9.748 APE10-dist-na 10.983 APE9-dist-in 5.988 G719S,T790M None None XRAY 2.34 0.197 0.244 A 334 297 4 0 0 0 [[712, 970]] 1.0 3vjn Homo sapiens TYR_EGFR_HUMAN TYR 7.9e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8DSWA P00533 696 1017 1210.0 ANP:61104 ATPlike Inactive DFGin 5.926 15.858 BLAminus -139.88, -174.48 62.3, 80.03 -97.39, 21.12 300.26, 86.52 -53.52, -37.16 none-none none 999.0 Saltbr-none 999.0 HRD-in -81.01, -46.59 69.43, -1.39 none-in-none SNCnin in-none ActLoopNT-in 2.921 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 105.32 APE8-dihe-in -90.45, 95.73 APE8-rot-na 32.83 APE67-dihe-in -75.5, -1.32 -70.5, -35.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.219 None None None XRAY 2.39 0.197 0.246 A 335 301 12 0 0 9 [[712, 970]] 1.0 8dsw Homo sapiens TYR_EGFR_HUMAN TYR 1.9e-85 292.3 3 259 257 854 855 856 858 860 745 -9999 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3VJOA P00533 696 1018 1210.0 ANP:2001 ATPlike Inactive DFGin 6.021 15.946 BLAminus -140.25, -165.5 56.51, 77.02 -90.26, 19.04 285.97, 94.98 -60.96, -7.67 in-out in 9.402 Saltbr-out 4.55 HRD-in -69.17, -43.62 63.06, 0.57 out-in-in SNCoii in-in ActLoopNT-in 2.921 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.49, 106.7 APE9-dihe-in -122.63, 146.56 APE8-dihe-in -79.91, 93.84 APE8-rot-na 34.61 APE67-dihe-in -67.26, -9.93 -59.74, -34.59 APE12-dist-na 12.246 APE11-dist-na 10.097 APE10-dist-na 10.762 APE9-dist-in 6.771 None None None XRAY 2.64 0.19 0.228 A 334 298 5 0 0 0 [[712, 970]] 1.0 3vjo Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2J5EA P00533 696 1020 1210.0 No_ligand No_ligand Inactive DFGin 5.3 14.197 BLAminus -154.01, -164.58 53.42, 84.81 -101.82, 45.94 302.49, 103.79 -74.44, -25.77 in-in in 8.243 Saltbr-in 2.692 HRD-in -64.71, -41.39 67.57, -8.8 in-in-out SNCiio in-out ActLoopNT-in 2.731 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -155.15, 44.39 APE9-dihe-in -124.14, 139.7 APE8-dihe-in -60.02, 128.79 APE8-rot-na 337.65 APE67-dihe-in -78.62, -5.59 -70.62, -32.81 APE12-dist-na 12.086 APE11-dist-na 10.266 APE10-dist-na 8.878 APE9-dist-in 5.855 None None CY0797 XRAY 3.1 0.191 0.255 A 327 310 0 0 0 0 [[712, 970]] 1.0 2j5e Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2GS6A P00533 696 1019 1210.0 No_ligand No_ligand Inactive DFGin 6.165 15.783 BLAminus -137.45, -165.85 53.49, 83.42 -103.4, 27.09 288.5, 89.52 -66.01, -11.62 in-out in 9.082 Saltbr-out 4.32 HRD-in -66.77, -39.61 61.96, 1.85 out-in-in SNCoii in-in ActLoopNT-in 2.898 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.14, 130.02 APE9-dihe-in -142.77, 141.16 APE8-dihe-in -66.85, 93.43 APE8-rot-na 36.58 APE67-dihe-in -61.45, -9.24 -52.09, -50.1 APE12-dist-na 11.797 APE11-dist-na 10.682 APE10-dist-na 10.788 APE9-dist-in 6.638 None None None XRAY 2.6 0.234 0.257 A 330 308 3 0 0 0 [[712, 970]] 1.0 2gs6 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4WRGA P00533 696 1019 1210.0 No_ligand No_ligand Inactive DFGin 6.122 15.603 BLAminus -132.42, -176.94 62.27, 81.51 -96.8, 20.71 293.04, 92.37 -69.52, -16.65 in-out in 9.35 Saltbr-out 3.876 HRD-in -77.59, -44.23 68.88, -0.09 out-in-none SNCoin in-none ActLoopNT-in 2.901 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 127.64 APE9-dihe-in -148.8, 140.64 APE8-dihe-in -74.11, 91.71 APE8-rot-na 32.62 APE67-dihe-in -71.26, -10.9 -55.8, -40.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.386 APE9-dist-in 6.499 None None CSX797 XRAY 1.9 0.198 0.212 A 330 288 14 0 0 2 [[712, 970]] 1.0 4wrg Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 1M14A P00533 696 1020 1210.0 No_ligand No_ligand Inactive DFGin 6.201 15.306 BLAminus -137.1, -165.71 56.53, 80.64 -98.41, 22.57 294.1, 95.61 -65.31, -3.31 in-out in 9.033 Saltbr-out 3.771 HRD-in -62.63, -48.49 66.44, -3.16 out-in-out SNCoio in-out ActLoopNT-in 3.026 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -157.3, 26.59 APE9-dihe-in -89.14, 140.3 APE8-dihe-in -65.78, 113.03 APE8-rot-na 27.12 APE67-dihe-in -69.67, -4.11 -63.81, -35.78 APE12-dist-na 10.78 APE11-dist-na 11.168 APE10-dist-na 9.373 APE9-dist-in 5.819 None None None XRAY 2.6 0.24 0.286 A 333 307 0 0 0 0 [[712, 970]] 1.0 1m14 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4R3PA P00533 696 1018 1210.0 No_ligand No_ligand Inactive DFGin 5.794 15.362 BLAminus -146.93, -167.92 65.0, 63.51 -93.37, 28.92 304.52, 102.77 -64.06, -32.87 in-out in 9.911 Saltbr-out 4.377 HRD-in -66.42, -39.7 60.93, 7.56 out-in-in SNCoii in-in ActLoopNT-in 3.08 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.82, 134.31 APE9-dihe-in -132.8, 153.08 APE8-dihe-in -81.36, 84.64 APE8-rot-na 29.25 APE67-dihe-in -67.65, -19.01 -54.83, -43.42 APE12-dist-na 11.381 APE11-dist-na 10.366 APE10-dist-na 11.193 APE9-dist-in 7.071 L858R None None XRAY 2.905 0.211 0.24 A 323 310 0 0 0 0 [[712, 970]] 1.0 4r3p Homo sapiens TYR_EGFR_HUMAN TYR 1e-86 296.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4R3RA P00533 696 1018 1210.0 No_ligand No_ligand Inactive DFGin 6.0 15.992 BLAminus -140.36, -167.26 58.15, 75.69 -100.1, 23.09 295.5, 88.92 -63.04, -27.57 in-out in 9.903 Saltbr-out 4.453 HRD-in -73.6, -40.66 63.35, 7.22 out-in-in SNCoii in-in ActLoopNT-in 2.97 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.96, 127.4 APE9-dihe-in -131.84, 150.27 APE8-dihe-in -74.01, 79.15 APE8-rot-na 27.96 APE67-dihe-in -75.06, 5.66 -47.7, -49.04 APE12-dist-na 12.447 APE11-dist-na 11.005 APE10-dist-na 11.812 APE9-dist-in 7.243 L858R None None XRAY 3.25 0.201 0.247 A 323 309 1 0 0 0 [[712, 970]] 1.0 4r3r Homo sapiens TYR_EGFR_HUMAN TYR 1e-86 296.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5CZHA P00533 696 1018 1210.0 No_ligand No_ligand Inactive DFGin 5.944 16.518 BLAminus -151.23, -172.37 58.73, 69.38 -89.33, 12.08 284.98, 95.07 -57.88, -36.95 in-out in 9.729 Saltbr-out 3.779 HRD-in -65.41, -46.33 76.27, -1.32 out-in-in SNCoii in-in ActLoopNT-in 2.93 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.64, 136.83 APE9-dihe-in -139.66, 148.82 APE8-dihe-in -82.84, 83.54 APE8-rot-na 30.96 APE67-dihe-in -76.98, -0.11 -56.8, -41.38 APE12-dist-na 12.145 APE11-dist-na 9.949 APE10-dist-na 10.556 APE9-dist-in 7.075 L858R None None XRAY 2.8 0.193 0.22 A 331 311 0 0 0 0 [[712, 970]] 1.0 5czh Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5CZIA P00533 696 1018 1210.0 No_ligand No_ligand Inactive DFGin 5.962 16.472 BLAminus -151.94, -175.87 60.47, 74.37 -93.41, 17.7 284.87, 92.98 -59.39, -35.75 out-out out 10.091 Saltbr-out 5.592 HRD-in -64.37, -47.77 77.54, -4.2 out-in-in SNCoii in-in ActLoopNT-in 2.942 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.78, 134.21 APE9-dihe-in -138.79, 149.63 APE8-dihe-in -81.85, 74.81 APE8-rot-na 31.34 APE67-dihe-in -78.0, 12.62 -42.86, -50.46 APE12-dist-na 12.214 APE11-dist-na 10.14 APE10-dist-na 10.86 APE9-dist-in 7.124 L858R None None XRAY 2.6 0.185 0.225 A 331 310 0 0 0 0 [[712, 970]] 1.0 5czi Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9U8CE P00533 696 982 1210.0 No_ligand No_ligand Inactive DFGin 5.939 14.307 BLAminus -152.41, -164.62 56.58, 56.51 -76.81, 18.0 309.73, 156.49 -60.06, -44.31 in-none in 8.595 Saltbr-none 999.0 HRD-in -116.68, -28.07 63.68, -60.22 none-in-out SNCnio in-out ActLoopNT-in 3.179 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -163.89, -170.0 APE9-dihe-out 55.12, 162.48 APE8-dihe-out -88.45, 22.1 APE8-rot-na 35.32 APE67-dihe-out -64.59, -45.6 31.36, -60.68 APE12-dist-na 11.618 APE11-dist-na 9.599 APE10-dist-na 11.463 APE9-dist-out 8.563 None None None XRAY 3.5 0.275 0.3 E 338 287 0 0 0 0 [[712, 970]] 1.0 9u8c Homo sapiens TYR_EGFR_HUMAN TYR 1.7e-85 292.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5XGNA P00533 697 1020 1210.0 85X:1101 Type1 Inactive DFGin 5.582 13.644 BLAminus -153.26, 170.97 58.79, 71.97 -87.87, 19.38 306.48, 67.69 -60.62, -38.74 in-in in 8.847 Saltbr-in 2.822 HRD-in -68.76, -41.85 71.08, 4.38 in-in-out SNCiio in-out ActLoopNT-in 3.097 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -65.98, -39.97 APE9-dihe-in -71.67, 158.09 APE8-dihe-in -63.95, 139.95 APE8-rot-na 31.68 APE67-dihe-in -61.46, -41.98 -63.96, -39.37 APE12-dist-na 11.99 APE11-dist-na 9.853 APE10-dist-na 6.736 APE9-dist-in 5.774 T790M,C797S None None XRAY 3.0 0.222 0.251 A 331 302 0 0 0 0 [[712, 970]] 1.0 5xgn Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8EMEB P00533 702 1007 1210.0 ZNL:1101 Type1 Inactive DFGin 6.136 12.914 BLAminus -133.84, 169.88 65.13, 69.02 -97.03, 123.1 348.61, 98.73 51.53, 999.0 out-out out 13.53 Saltbr-out 12.055 HRD-in -94.64, -53.18 73.04, -20.06 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 68.1 APE8-rot-na 28.3 APE67-dihe-in -72.67, -5.8 -55.65, -44.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 3.32 0.285 0.318 B 331 282 19 0 0 19 [[712, 970]] 1.0 8eme Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7A6IA P00533 703 984 1210.0 R1W:1105 Type1 Inactive DFGin 5.438 15.201 BLAminus -139.42, -172.85 63.21, 85.24 -101.8, 27.35 298.55, 86.72 -65.73, -19.8 out-out out 10.522 Saltbr-out 4.139 HRD-in -70.13, -49.68 70.38, 6.04 out-in-out SNCoio in-out ActLoopNT-in 2.901 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.13, -14.58 APE9-dihe-in -89.01, 142.09 APE8-dihe-in -63.08, 128.71 APE8-rot-na 335.68 APE67-dihe-in -74.24, -4.43 -65.48, -25.25 APE12-dist-na 11.501 APE11-dist-na 10.628 APE10-dist-na 6.686 APE9-dist-in 4.925 T790M,V948R None None XRAY 2.4 0.204 0.239 A 333 282 0 0 0 0 [[712, 970]] 1.0 7a6i Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2JIUA P00533 696 1016 1210.0 AEE:2017 Type1 Inactive DFGin 5.634 14.082 BLAminus -145.49, 179.31 63.52, 89.73 -108.67, 24.16 309.25, 93.65 -34.66, -27.93 in-out in 9.641 Saltbr-out 4.002 HRD-in -49.5, -61.5 85.29, -11.16 out-in-in SNCoii in-in ActLoopNT-in 3.445 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -95.44, 148.67 APE9-dihe-in -156.98, 144.14 APE8-dihe-in -91.11, 79.49 APE8-rot-na 27.16 APE67-dihe-in -68.15, 3.02 -38.52, -39.86 APE12-dist-na 11.717 APE11-dist-na 9.516 APE10-dist-na 10.218 APE9-dist-in 6.625 T790M None None XRAY 3.05 0.214 0.277 A 328 304 0 0 0 0 [[712, 970]] 1.0 2jiu Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5FEQA P00533 697 1017 1210.0 5XH:1101 Type1 Inactive DFGin 6.502 15.107 BLAminus -131.66, -168.96 59.17, 85.25 -106.59, 25.28 290.32, 115.86 -66.06, -31.05 in-in in 8.3 Saltbr-in 3.09 HRD-in -58.87, -52.1 73.02, -13.69 in-in-out SNCiio in-out ActLoopNT-in 2.855 ActLoopCT-out TYR APEdihe_iioao APEdist_aaai APE10-dihe-in -92.25, 143.06 APE9-dihe-in -132.04, 157.2 APE8-dihe-out -53.9, -51.85 APE8-rot-na 333.25 APE67-dihe-out -72.26, -25.76 82.02, -51.56 APE12-dist-na 999.0 APE11-dist-na 10.248 APE10-dist-na 11.525 APE9-dist-in 7.17 T790M None None XRAY 3.4 0.17 0.222 A 328 290 10 0 0 5 [[712, 970]] 1.0 5feq Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5GMPA P00533 696 1019 1210.0 F62:1101 Type1 Inactive DFGin 6.371 15.003 BLAminus -149.53, -179.31 60.35, 57.18 -88.01, 5.26 310.58, 112.94 -57.9, -38.1 in-in in 8.565 Saltbr-in 3.293 HRD-in -63.5, -41.57 61.77, -1.09 in-in-out SNCiio in-out ActLoopNT-in 2.613 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 150.95 APE8-dihe-in -84.68, 73.41 APE8-rot-na 32.34 APE67-dihe-in -63.78, -38.8 -63.92, -38.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.078 T790M None None XRAY 2.797 0.213 0.241 A 331 305 11 0 0 11 [[712, 970]] 1.0 5gmp Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5GTZA P00533 697 1020 1210.0 81C:1101 Type1 Inactive DFGin 6.273 15.044 BLAminus -158.62, -172.16 60.32, 68.58 -94.78, 16.57 297.08, 118.19 -59.97, -37.98 in-in in 8.18 Saltbr-in 3.508 HRD-in -77.38, -45.78 71.04, -1.29 in-in-out SNCiio in-out ActLoopNT-in 2.748 ActLoopCT-out TYR APEdihe_nioao APEdist_aaai APE10-dihe-none 999.0, 169.8 APE9-dihe-in -135.97, 147.58 APE8-dihe-out -69.99, -39.44 APE8-rot-na 342.53 APE67-dihe-out -69.1, -30.25 74.68, -57.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.198 APE9-dist-in 7.834 T790M None None XRAY 2.999 0.191 0.23 A 331 317 7 0 0 7 [[712, 970]] 1.0 5gtz Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4WD5A P00533 694 1021 1210.0 3LH:1101 Type1 Inactive DFGin 5.458 14.327 BLAminus -163.55, -174.21 53.25, 61.87 -88.09, 5.1 292.2, 106.75 -57.38, -39.62 out-out out 10.101 Saltbr-out 3.909 HRD-out -88.47, 107.17 -64.41, -38.01 out-in-out SNCoio in-out ActLoopNT-in 3.213 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -63.87, 132.32 APE9-dihe-in -145.35, 143.46 APE8-dihe-in -90.09, 123.82 APE8-rot-na 33.05 APE67-dihe-in -61.34, -40.63 -65.68, -40.65 APE12-dist-na 11.852 APE11-dist-na 9.456 APE10-dist-na 10.038 APE9-dist-out 8.073 T790M None None XRAY 3.3 0.211 0.239 A 331 307 0 0 0 0 [[712, 970]] 1.0 4wd5 Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3UG2A P00533 697 1018 1210.0 IRE:1 Type1 Inactive DFGin 6.128 16.297 BLAminus -131.79, -168.85 59.62, 80.02 -93.0, 13.81 280.85, 97.63 -52.25, -28.71 in-out in 9.318 Saltbr-out 4.942 HRD-in -79.26, -48.84 71.4, -5.34 out-in-in SNCoii in-in ActLoopNT-in 2.912 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.39, 125.11 APE9-dihe-in -140.0, 141.56 APE8-dihe-in -80.99, 105.31 APE8-rot-na 37.43 APE67-dihe-in -66.78, -11.55 -70.88, -39.23 APE12-dist-na 11.844 APE11-dist-na 9.721 APE10-dist-na 10.858 APE9-dist-in 6.709 G719S,T790M None None XRAY 2.5 0.19 0.249 A 334 299 8 0 0 0 [[712, 970]] 1.0 3ug2 Homo sapiens TYR_EGFR_HUMAN TYR 7.9e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9S3XA P00533 696 1019 1210.0 A1JLU:1101 Type1 Inactive DFGin 5.898 15.374 BLAminus -132.89, -174.21 64.4, 85.9 -100.4, 11.48 285.57, 104.46 -52.15, -25.42 in-out in 8.752 Saltbr-out 3.953 HRD-in -71.92, -52.5 74.51, 0.04 out-in-in SNCoii in-in ActLoopNT-in 2.994 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -95.86, 101.54 APE9-dihe-in -118.22, 149.08 APE8-dihe-in -83.81, 77.9 APE8-rot-na 32.37 APE67-dihe-in -70.9, 0.06 -54.84, -44.82 APE12-dist-na 11.356 APE11-dist-na 11.364 APE10-dist-na 11.162 APE9-dist-in 7.085 None None None XRAY 2.423 0.192 0.246 A 324 324 0 0 0 0 [[712, 970]] 1.0 9s3x Homo sapiens TYR_EGFR_HUMAN TYR 3.2e-86 294.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9D3VA P00533 696 1019 1210.0 A1A5V:61101 Type1 Inactive DFGin 6.156 15.669 BLAminus -134.45, -170.65 71.87, 82.32 -100.43, 22.36 284.3, 100.25 -87.06, 2.75 in-in in 8.809 Saltbr-in 2.83 HRD-in -80.28, -49.34 80.85, -3.01 in-in-out SNCiio in-out ActLoopNT-in 2.795 ActLoopCT-out TYR APEdihe_ooiai APEdist_aaao APE10-dihe-out -143.14, 48.28 APE9-dihe-out -110.53, -27.12 APE8-dihe-in -80.27, 56.08 APE8-rot-na 30.72 APE67-dihe-in -74.59, -11.22 -58.28, -33.79 APE12-dist-na 5.37 APE11-dist-na 7.997 APE10-dist-na 10.755 APE9-dist-out 8.036 C797S,E865A,E866A,K867A None None XRAY 2.32 0.299 0.329 A 330 315 0 0 0 0 [[712, 970]] 1.0 9d3v Homo sapiens TYR_EGFR_HUMAN TYR 3.5e-86 294.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2ITWA P00533 696 1018 1210.0 ITQ:2018 Type1 Inactive DFGin 5.853 15.473 BLAminus -142.09, -169.34 57.7, 89.5 -104.27, 29.57 295.26, 97.45 -82.52, 26.8 in-out in 9.115 Saltbr-out 3.924 HRD-in -65.22, -40.15 57.71, 1.3 out-in-in SNCoii in-in ActLoopNT-in 3.015 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -54.02, 133.84 APE9-dihe-in -142.1, 144.15 APE8-dihe-in -78.28, 106.03 APE8-rot-na 33.32 APE67-dihe-in -72.11, 0.73 -63.71, -37.22 APE12-dist-na 12.476 APE11-dist-na 10.833 APE10-dist-na 10.644 APE9-dist-in 6.454 None None None XRAY 2.88 0.191 0.256 A 327 301 0 0 0 0 [[712, 970]] 1.0 2itw Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9H46A P00533 696 1019 1210.0 A1ISA:1101 Type1 Inactive DFGin 6.363 15.169 BLAminus -149.47, -177.58 62.62, 58.11 -90.1, 3.13 314.38, 111.86 -47.48, -44.04 in-in in 8.743 Saltbr-in 3.221 HRD-in -63.57, -45.69 65.43, -1.15 in-in-out SNCiio in-out ActLoopNT-in 2.657 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.98 APE8-dihe-in -85.78, 71.07 APE8-rot-na 35.5 APE67-dihe-in -68.16, -32.18 -60.78, -38.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.139 None None None XRAY 3.163 0.214 0.256 A 328 305 11 0 0 11 [[712, 970]] 1.0 9h46 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4JQ7A P00533 696 1019 1210.0 KJQ:61001 Type1 Inactive DFGin 5.766 14.947 BLAminus -142.56, -163.87 57.95, 63.34 -87.13, 23.58 297.46, 96.17 -62.25, -27.78 in-in in 8.568 Saltbr-in 2.764 HRD-in -72.72, -48.84 71.04, 5.2 in-in-out SNCiio in-out ActLoopNT-in 2.973 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 57.84, 54.36 APE9-dihe-in -113.81, 143.75 APE8-dihe-in -54.56, 110.74 APE8-rot-na 332.06 APE67-dihe-in -75.49, -11.01 -64.74, -36.9 APE12-dist-na 11.206 APE11-dist-na 10.439 APE10-dist-na 10.546 APE9-dist-in 6.043 None None None XRAY 2.73 0.208 0.237 A 328 303 0 0 0 0 [[712, 970]] 1.0 4jq7 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4JQ8A P00533 696 1019 1210.0 KJ8:61001 Type1 Inactive DFGin 5.802 14.534 BLAminus -152.56, -167.91 59.0, 68.71 -90.88, 39.65 318.01, 84.24 -67.29, -22.27 in-in in 8.77 Saltbr-in 2.669 HRD-in -62.97, -50.96 69.15, 4.05 in-in-out SNCiio in-out ActLoopNT-in 2.905 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 73.35, 63.7 APE9-dihe-in -115.81, 140.9 APE8-dihe-in -54.3, 111.45 APE8-rot-na 331.91 APE67-dihe-in -77.07, -6.6 -65.94, -34.63 APE12-dist-na 11.24 APE11-dist-na 10.155 APE10-dist-na 10.36 APE9-dist-in 5.794 None None None XRAY 2.83 0.186 0.232 A 328 303 0 0 0 0 [[712, 970]] 1.0 4jq8 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4JR3A P00533 696 1019 1210.0 KJR:61001 Type1 Inactive DFGin 5.761 15.075 BLAminus -140.13, -158.24 57.52, 55.13 -81.24, 25.3 299.15, 90.98 -63.61, -23.19 in-in in 8.725 Saltbr-in 2.799 HRD-in -73.26, -46.08 69.71, 7.12 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 61.6, 58.49 APE9-dihe-in -120.62, 144.52 APE8-dihe-in -57.7, 110.97 APE8-rot-na 334.09 APE67-dihe-in -75.24, -3.2 -70.93, -34.67 APE12-dist-na 11.014 APE11-dist-na 10.21 APE10-dist-na 10.405 APE9-dist-in 6.037 None None None XRAY 2.7 0.215 0.248 A 328 303 0 0 0 0 [[712, 970]] 1.0 4jr3 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4JRVA P00533 696 1019 1210.0 KJV:61001 Type1 Inactive DFGin 5.711 14.884 BLAminus -149.4, -166.43 54.55, 65.72 -84.05, 22.1 300.59, 98.04 -61.96, -15.57 in-in in 8.679 Saltbr-in 2.876 HRD-in -64.45, -49.37 72.67, 0.22 in-in-out SNCiio in-out ActLoopNT-in 2.939 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 59.5, 55.62 APE9-dihe-in -115.47, 148.63 APE8-dihe-in -62.21, 114.76 APE8-rot-na 334.99 APE67-dihe-in -77.09, -6.83 -72.28, -36.15 APE12-dist-na 12.193 APE11-dist-na 9.946 APE10-dist-na 10.21 APE9-dist-in 6.057 None None None XRAY 2.8 0.194 0.227 A 328 300 3 0 0 0 [[712, 970]] 1.0 4jrv Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8PNZA P00533 695 1018 1210.0 2I0:1101 Type1 Inactive DFGin 6.01 15.383 BLAminus -127.34, -173.34 63.69, 76.51 -90.6, 17.7 292.67, 103.42 -61.2, -18.12 in-out in 8.997 Saltbr-out 3.994 HRD-in -66.3, -45.64 66.52, 2.69 out-in-in SNCoii in-in ActLoopNT-in 2.976 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.02, 110.59 APE9-dihe-in -113.33, 137.14 APE8-dihe-in -76.85, 91.84 APE8-rot-na 30.55 APE67-dihe-in -68.82, -7.15 -51.27, -45.51 APE12-dist-na 11.476 APE11-dist-na 9.801 APE10-dist-na 10.628 APE9-dist-in 6.571 None None None XRAY 2.51 0.229 0.284 A 329 311 2 0 0 0 [[712, 970]] 1.0 8pnz Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5JEBA P00533 699 999 1210.0 6JS:61003 Type1 Inactive DFGin 5.405 13.673 BLAminus -139.58, -161.83 51.6, 77.22 -93.66, 22.71 298.5, 91.43 -63.19, -12.31 in-in in 8.515 Saltbr-in 2.555 HRD-in -75.13, -37.7 63.23, 2.32 in-in-out SNCiio in-out ActLoopNT-in 3.182 ActLoopCT-out TYR APEdihe_oioao APEdist_aaai APE10-dihe-out 60.87, 49.75 APE9-dihe-in -128.7, 148.47 APE8-dihe-out -58.38, -26.4 APE8-rot-na 13.7 APE67-dihe-out -62.13, -29.98 69.61, -49.65 APE12-dist-na 11.647 APE11-dist-na 11.403 APE10-dist-na 9.642 APE9-dist-in 6.241 V948R None None XRAY 3.298 0.244 0.27 A 337 299 2 0 0 0 [[712, 970]] 1.0 5jeb Homo sapiens TYR_EGFR_HUMAN TYR 8.7e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 1M17A P00533 696 1019 1210.0 AQ4:60999 Type1 Inactive DFGin 5.986 14.85 BLAminus -146.67, -165.67 54.04, 80.71 -94.47, 20.74 294.26, 91.25 -51.66, -26.88 in-in in 8.652 Saltbr-in 3.053 HRD-in -22.63, -70.63 76.83, 0.59 in-in-out SNCiio in-out ActLoopNT-in 3.228 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -142.06, 19.04 APE9-dihe-in -100.5, 138.82 APE8-dihe-in -68.53, 114.83 APE8-rot-na 28.55 APE67-dihe-in -70.29, 3.79 -62.89, -39.72 APE12-dist-na 11.13 APE11-dist-na 11.463 APE10-dist-na 8.606 APE9-dist-in 5.972 None None None XRAY 2.6 0.253 0.295 A 333 312 0 0 0 0 [[712, 970]] 1.0 1m17 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8HY7A P00533 696 1019 1210.0 NSO:1102 Type1 Inactive DFGin 6.61 15.259 BLAminus -143.68, -160.85 43.56, 82.0 -95.96, 31.22 296.84, 81.26 -64.67, -15.36 in-out in 8.353 Saltbr-out 4.947 HRD-in -76.66, -43.51 57.16, 15.85 out-in-none SNCoin in-none ActLoopNT-in 2.85 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.01 APE8-dihe-in -103.04, 85.55 APE8-rot-na 35.06 APE67-dihe-in -63.02, -5.07 -66.24, -45.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.503 E865A,E866A,K867A None None XRAY 2.91 0.198 0.251 A 330 299 18 0 0 14 [[712, 970]] 1.0 8hy7 Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6JRKA P00533 696 1018 1210.0 C6O:1101 Type1 Inactive DFGin 6.151 15.687 BLAminus -133.54, -177.31 58.75, 61.62 -83.97, 49.61 313.83, 81.4 -63.76, -39.01 in-out in 8.7 Saltbr-out 4.094 HRD-in -79.02, -44.23 61.1, 3.96 out-in-none SNCoin in-none ActLoopNT-in 3.355 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 143.52 APE8-dihe-in -87.62, 79.08 APE8-rot-na 33.64 APE67-dihe-in -74.14, -9.21 -64.07, -35.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.413 E865A,E866A,K867A None None XRAY 2.796 0.2 0.236 A 331 283 23 0 0 15 [[712, 970]] 1.0 6jrk Homo sapiens TYR_EGFR_HUMAN TYR 5.8e-87 297.3 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2ITUA P00533 696 1019 1210.0 ITQ:2020 Type1 Inactive DFGin 6.271 15.627 BLAminus -134.44, -171.23 59.25, 91.54 -108.34, 5.63 292.29, 91.0 -53.91, 9.05 in-out in 9.044 Saltbr-out 3.774 HRD-in -68.49, -42.0 55.69, 2.63 out-in-none SNCoin in-none ActLoopNT-in 2.893 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.97 APE8-dihe-in -92.92, 81.72 APE8-rot-na 21.85 APE67-dihe-in -65.11, -0.4 -64.03, -44.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.666 L858R None None XRAY 2.8 0.201 0.258 A 327 304 10 0 0 10 [[712, 970]] 1.0 2itu Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2ITZA P00533 697 1020 1210.0 IRE:2021 Type1 Inactive DFGin 5.737 14.231 BLAminus -131.03, -170.43 64.99, 76.02 -93.07, 24.13 302.2, 98.1 -48.52, -35.04 in-out in 8.129 Saltbr-out 3.634 HRD-in -66.91, -39.96 62.5, 6.79 out-in-none SNCoin in-none ActLoopNT-in 2.691 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 109.03 APE8-dihe-in -83.03, 97.62 APE8-rot-na 33.89 APE67-dihe-in -61.76, -16.39 -73.06, -45.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.389 L858R None None XRAY 2.8 0.205 0.255 A 327 303 10 0 0 10 [[712, 970]] 1.0 2itz Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6JWLA P00533 696 1020 1210.0 YY3:1101 Type1 Inactive DFGin 6.268 15.147 BLAminus -148.94, -172.35 58.18, 67.62 -92.49, 12.45 290.61, 97.33 -59.59, -36.09 in-in in 8.293 Saltbr-in 2.972 HRD-in -73.51, -46.95 65.44, 11.82 in-in-out SNCiio in-out ActLoopNT-in 2.913 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 57.66, 41.1 APE9-dihe-in -69.1, 148.77 APE8-dihe-in -91.07, 95.73 APE8-rot-na 33.84 APE67-dihe-in -61.2, -38.42 -64.68, -39.82 APE12-dist-na 10.839 APE11-dist-na 11.973 APE10-dist-na 11.986 APE9-dist-in 7.609 L858R None None XRAY 2.551 0.208 0.242 A 331 319 6 0 0 6 [[712, 970]] 1.0 6jwl Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7T4JA P00533 701 984 1210.0 R28:61101 Type1 Inactive DFGin 6.008 14.415 BLAminus -144.5, 169.5 68.77, 85.47 -96.42, 20.57 291.54, 77.61 -59.75, -25.89 in-in in 8.017 Saltbr-in 2.568 HRD-in -76.71, -52.5 81.16, 2.81 in-in-out SNCiio in-out ActLoopNT-in 2.877 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 45.96, 61.38 APE9-dihe-in -145.01, 131.44 APE8-dihe-in -84.06, 121.96 APE8-rot-na 31.03 APE67-dihe-in -61.46, 1.98 -82.97, -44.13 APE12-dist-na 11.773 APE11-dist-na 11.055 APE10-dist-na 8.533 APE9-dist-in 6.334 V948R None None XRAY 2.2 0.227 0.278 A 331 276 8 0 0 0 [[712, 970]] 1.0 7t4j Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8PO0A P00533 695 1018 1210.0 2I6:61101 Type1 Inactive DFGin 5.565 15.802 BLAminus -122.92, -171.86 50.53, 59.02 -51.49, -62.41 283.3, 72.87 65.92, -46.76 in-none in 8.371 Saltbr-none 999.0 HRD-in -55.42, -36.9 57.38, 6.99 none-in-out SNCnio in-out ActLoopNT-in 3.012 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -134.75, 28.72 APE9-dihe-in -65.92, 135.7 APE8-dihe-in -64.04, 113.56 APE8-rot-na 21.15 APE67-dihe-in -56.75, -45.28 -67.59, -27.7 APE12-dist-na 11.771 APE11-dist-na 10.913 APE10-dist-na 11.645 APE9-dist-in 6.357 None None None XRAY 2.523 0.318 0.376 A 332 307 7 0 0 0 [[712, 970]] 1.0 8po0 Homo sapiens TYR_EGFR_HUMAN TYR 1.6e-85 292.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9U8CA P00533 696 989 1210.0 A1L8T:61101 Type1 Inactive DFGin 5.138 14.224 BLAminus -152.72, -166.88 55.62, 62.26 -74.1, 21.88 305.31, 73.74 -53.06, -42.51 in-out in 8.537 Saltbr-out 3.658 HRD-in -112.78, -28.58 64.39, -55.61 out-in-out SNCoio in-out ActLoopNT-in 3.308 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 63.95, 52.79 APE9-dihe-in -131.72, 146.15 APE8-dihe-in -83.5, 103.66 APE8-rot-na 25.73 APE67-dihe-in -64.45, -43.78 -72.16, -36.45 APE12-dist-na 12.368 APE11-dist-na 11.06 APE10-dist-na 8.394 APE9-dist-in 7.963 None None None XRAY 3.5 0.275 0.3 A 338 292 2 0 0 0 [[712, 970]] 1.0 9u8c Homo sapiens TYR_EGFR_HUMAN TYR 1.7e-85 292.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9U8CC P00533 696 980 1210.0 A1L8T:61101 Type1 Inactive DFGin 5.25 14.655 BLAminus -150.18, -166.33 56.37, 62.15 -74.03, 19.4 282.34, 71.74 -55.17, -41.51 in-out in 8.222 Saltbr-out 4.157 HRD-in -113.86, -26.91 64.43, -58.55 out-in-in SNCoii in-in ActLoopNT-in 3.3 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.57, 94.53 APE9-dihe-in -139.46, 143.63 APE8-dihe-in -83.28, 104.5 APE8-rot-na 28.04 APE67-dihe-in -65.21, -41.71 -68.24, -37.37 APE12-dist-na 8.664 APE11-dist-na 10.775 APE10-dist-na 8.429 APE9-dist-in 7.276 None None None XRAY 3.5 0.275 0.3 C 338 281 4 0 0 0 [[712, 970]] 1.0 9u8c Homo sapiens TYR_EGFR_HUMAN TYR 1.7e-85 292.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4R5SA P00533 697 1018 1210.0 FI3:1101 Type1.5_Back Inactive DFGin 5.101 14.574 BLAminus -157.2, -179.86 56.93, 47.29 -82.16, 60.06 358.48, 60.04 -65.03, -39.71 in-out in 9.457 Saltbr-out 4.992 HRD-in -64.01, -46.28 78.34, -4.7 out-in-out SNCoio in-out ActLoopNT-in 3.133 ActLoopCT-out TYR APEdihe_nnoao APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.94 APE8-dihe-out -63.79, -43.43 APE8-rot-na 31.31 APE67-dihe-out -60.79, -39.82 71.82, -57.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.805 L858R None None XRAY 3.001 0.209 0.239 A 331 299 9 0 0 9 [[712, 970]] 1.0 4r5s Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3W2OA P00533 698 1017 1210.0 03P:61101 Type1.5_Front Inactive DFGin 6.063 16.853 BLAminus -136.96, -170.56 62.22, 87.75 -101.43, 18.89 291.4, 91.83 -57.44, -26.38 out-out out 10.675 Saltbr-out 8.523 HRD-in -77.47, -53.25 75.27, 2.22 out-in-in SNCoii in-in ActLoopNT-in 2.888 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.73, 104.36 APE9-dihe-in -123.36, 141.58 APE8-dihe-in -79.92, 73.45 APE8-rot-na 24.57 APE67-dihe-in -74.19, -6.86 -50.44, -40.99 APE12-dist-na 11.686 APE11-dist-na 11.26 APE10-dist-na 10.559 APE9-dist-in 7.223 T790M,L858R None None XRAY 2.35 0.182 0.216 A 331 304 0 0 0 0 [[712, 970]] 1.0 3w2o Homo sapiens TYR_EGFR_HUMAN TYR 8.7e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3W2PA P00533 698 1018 1210.0 W2P:61101 Type1.5_Front Inactive DFGin 6.166 17.253 BLAminus -131.72, -170.04 61.76, 87.11 -100.15, 22.27 288.83, 85.51 -59.78, -24.55 out-out out 10.896 Saltbr-out 9.197 HRD-in -74.33, -49.37 70.61, 3.25 out-in-in SNCoii in-in ActLoopNT-in 2.893 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -98.88, 109.86 APE9-dihe-in -115.54, 146.26 APE8-dihe-in -77.33, 72.71 APE8-rot-na 32.52 APE67-dihe-in -72.04, -9.29 -47.42, -44.04 APE12-dist-na 11.857 APE11-dist-na 11.036 APE10-dist-na 11.483 APE9-dist-in 7.134 T790M,L858R None None XRAY 2.05 0.181 0.206 A 331 307 0 0 0 0 [[712, 970]] 1.0 3w2p Homo sapiens TYR_EGFR_HUMAN TYR 8.7e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3W2QA P00533 698 1017 1210.0 HKI:61101 Type1.5_Front Inactive DFGin 6.184 16.72 BLAminus -130.59, -173.46 61.6, 82.75 -98.16, 22.05 287.41, 85.18 -65.26, -18.03 out-out out 10.536 Saltbr-out 5.753 HRD-in -77.64, -48.42 70.13, 4.48 out-in-in SNCoii in-in ActLoopNT-in 2.931 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.12, 121.01 APE9-dihe-in -124.15, 141.54 APE8-dihe-in -80.25, 75.51 APE8-rot-na 32.95 APE67-dihe-in -72.98, -8.46 -42.37, -46.09 APE12-dist-na 12.571 APE11-dist-na 10.333 APE10-dist-na 10.606 APE9-dist-in 7.01 T790M,L858R None None XRAY 2.2 0.177 0.2 A 331 306 0 0 0 0 [[712, 970]] 1.0 3w2q Homo sapiens TYR_EGFR_HUMAN TYR 8.7e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2EB3A P00533 696 1018 1210.0 ANP:2001 ATPlike Inactive DFGin 4.666 14.869 BLAplus -146.31, -170.86 55.73, 31.55 -96.53, 44.19 45.64, 108.62 -72.56, -59.05 in-in in 8.594 Saltbr-in 3.443 HRD-out -53.85, 138.27 -123.62, 23.93 in-in-none SNCiin in-none ActLoopNT-in 2.585 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 154.55 APE8-dihe-in -88.38, 74.74 APE8-rot-na 41.16 APE67-dihe-in -67.41, -11.07 -62.2, -31.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.893 None None None XRAY 2.84 0.19 0.236 A 334 294 15 0 0 14 [[712, 970]] 1.0 2eb3 Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-86 296.3 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5EDPA P00533 697 1018 1210.0 No_ligand No_ligand Inactive DFGin 4.881 15.135 BLAplus -133.67, -173.57 50.41, 39.76 -96.85, 38.29 47.92, 89.07 -95.7, 31.38 in-in in 9.022 Saltbr-in 2.8 HRD-in -53.07, -59.18 77.76, -14.44 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 107.67 APE9-dihe-in -130.59, 131.78 APE8-dihe-in -87.86, 78.59 APE8-rot-na 23.14 APE67-dihe-in -63.28, -8.54 -48.69, -47.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.924 APE9-dist-in 7.511 T790M,L858R,E865A,E866A,K867A None None XRAY 2.9 0.202 0.244 A 331 295 17 0 0 15 [[712, 970]] 1.0 5edp Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5XGMA P00533 696 1019 1210.0 85X:1101 Type1 Inactive DFGin 4.793 14.741 BLAplus -144.29, 167.69 73.25, 26.11 -72.78, -33.2 21.91, 88.3 -70.25, 109.4 in-in in 8.876 Saltbr-in 2.988 HRD-in -64.53, -47.15 68.98, -5.48 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 146.56 APE9-dihe-in -67.52, 143.4 APE8-dihe-in -85.81, 75.7 APE8-rot-na 32.24 APE67-dihe-in -60.03, -28.56 -62.99, -40.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.617 APE9-dist-out 8.502 T790M None None XRAY 2.952 0.204 0.232 A 331 288 20 0 0 16 [[712, 970]] 1.0 5xgm Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6JRJA P00533 696 1018 1210.0 C6O:1101 Type1 Inactive DFGin 5.767 14.696 BLAplus -146.58, 171.3 63.59, 36.35 -83.45, 70.49 10.38, 12.45 -62.95, -40.46 in-out in 8.434 Saltbr-out 4.091 HRD-in -65.15, -46.37 77.52, -6.84 out-in-none SNCoin in-none ActLoopNT-in 3.374 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 39.25 APE8-rot-na 31.52 APE67-dihe-in -71.27, -25.91 -64.49, -36.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,C797S,E865A,E866A,K867A None None XRAY 2.943 0.207 0.246 A 331 288 19 0 0 15 [[712, 970]] 1.0 6jrj Homo sapiens TYR_EGFR_HUMAN TYR 3.3e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5Y25A P00533 698 1017 1210.0 8LU:61100 Type1 Inactive DFGin 5.072 15.24 BLAplus -135.07, -176.36 57.55, 57.43 -118.69, 40.35 43.37, 101.63 -71.29, -8.91 in-in in 9.165 Saltbr-in 2.935 HRD-in -62.19, -43.66 68.83, -3.95 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.04 APE8-dihe-in -99.62, 92.32 APE8-rot-na 24.61 APE67-dihe-in -66.0, -21.26 -68.05, -40.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.503 T790M,L858R None None XRAY 3.102 0.217 0.246 A 332 291 19 0 0 16 [[712, 970]] 1.0 5y25 Homo sapiens TYR_EGFR_HUMAN TYR 8.8e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5EDRA P00533 697 1018 1210.0 5N4:1101 Type1 Inactive DFGin 4.476 14.518 BLAplus -140.88, -176.91 54.86, 32.13 -91.81, -13.07 46.94, 81.82 -70.23, -16.55 in-in in 8.406 Saltbr-in 2.881 HRD-in -60.44, -58.52 79.57, -12.75 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.03 APE8-dihe-in -82.6, 73.37 APE8-rot-na 27.56 APE67-dihe-in -63.51, -16.69 -49.51, -47.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.483 T790M,L858R,E865A,E866A,K867A None None XRAY 2.6 0.192 0.215 A 331 299 18 0 0 16 [[712, 970]] 1.0 5edr Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5EM5A P00533 697 1019 1210.0 5Q2:1101 Type1 Inactive DFGin 4.838 15.181 BLAplus -136.71, -176.75 58.33, 34.93 -98.56, 19.71 49.9, 87.47 -81.65, -7.27 in-in in 8.914 Saltbr-in 3.101 HRD-in -55.65, -58.2 76.7, -11.43 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.16 APE8-dihe-in -83.15, 78.58 APE8-rot-na 26.69 APE67-dihe-in -63.88, -8.73 -52.94, -46.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.728 T790M,L858R,E865A,E866A,K867A None None XRAY 2.65 0.213 0.223 A 331 298 20 0 0 16 [[712, 970]] 1.0 5em5 Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6TFUB P00533 700 984 1210.0 N7K:1101 Type1.5_Back Inactive DFGin 5.089 13.784 BLAplus -138.35, -177.09 60.56, 54.11 -121.84, -30.08 55.57, 85.82 -88.61, 60.91 out-none out 13.449 Saltbr-none 999.0 HRD-in -75.19, -52.75 80.37, -17.47 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.89 APE8-dihe-in -74.28, 71.89 APE8-rot-na 29.18 APE67-dihe-in -75.39, -6.33 -57.09, -40.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.255 T790M,V948R None None XRAY 2.0 0.203 0.233 B 333 260 25 0 0 16 [[712, 970]] 1.0 6tfu Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5EDQA P00533 697 1018 1210.0 5N3:1101 Type1.5_Back Inactive DFGin 4.744 14.666 BLAplus -140.42, 178.58 58.92, 32.84 -88.45, -6.6 42.16, 85.52 -82.15, 42.09 in-in in 8.508 Saltbr-in 2.903 HRD-in -61.82, -59.01 77.45, -15.01 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.42 APE8-dihe-in -88.64, 71.48 APE8-rot-na 24.56 APE67-dihe-in -66.17, -8.57 -52.55, -46.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.808 T790M,L858R,E865A,E866A,K867A None None XRAY 2.8 0.209 0.241 A 331 298 16 0 0 16 [[712, 970]] 1.0 5edq Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8A27A P00533 701 985 1210.0 KY9:1102 Type3 Inactive DFGin 5.672 14.381 BLAplus -145.52, -178.77 57.22, 42.47 -100.42, -1.68 47.88, 94.3 -89.32, 20.08 out-out out 13.238 Saltbr-out 11.714 HRD-in -70.42, -54.97 75.01, -8.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.04 APE8-dihe-in -81.29, 59.61 APE8-rot-na 35.43 APE67-dihe-in -73.27, -7.01 -50.89, -40.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.484 None None None XRAY 1.07 0.126 0.16 A 326 269 16 0 0 16 [[712, 970]] 1.0 8a27 Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8A2AA P00533 700 1019 1210.0 KY9:1101 Type3 Inactive DFGin 5.117 14.356 BLAplus -139.34, 175.57 57.42, 45.45 -97.33, -2.42 49.8, 85.36 -104.26, 24.72 out-out out 13.637 Saltbr-out 12.255 HRD-in -68.19, -54.53 72.52, -7.02 out-out-out SNCooo out-out ActLoopNT-out 6.62 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.68 APE8-dihe-in -79.56, 62.59 APE8-rot-na 33.47 APE67-dihe-in -77.17, -2.3 -52.5, -40.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.037 None None None XRAY 1.43 0.19 0.223 A 326 306 8 0 0 8 [[712, 970]] 1.0 8a2a Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXIC P00533 700 1007 1210.0 8BS:1101 Type1 Inactive DFGin 7.177 14.411 BLBminus -132.91, 172.84 59.41, 71.0 -110.11, -162.74 349.91, 78.05 63.69, 999.0 out-out out 13.513 Saltbr-out 12.49 HRD-in -66.45, -56.15 77.12, -7.0 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.52 APE8-dihe-in -79.96, 70.34 APE8-rot-na 30.69 APE67-dihe-in -73.05, -5.2 -53.29, -45.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.533 T790M,V948R None None XRAY 3.0 0.278 0.312 C 331 283 21 0 0 18 [[712, 970]] 1.0 7jxi Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4RJ6A P00533 697 1018 1210.0 3R0:1102 Type1 Inactive DFGin 5.322 14.423 BLBminus -136.99, -168.04 64.48, 79.04 -92.03, -167.17 304.29, 99.79 103.27, -12.3 in-in in 8.534 Saltbr-in 2.793 HRD-in -56.87, -52.67 70.63, 0.35 in-in-none SNCiin in-none ActLoopNT-in 3.033 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.81 APE8-dihe-in -85.67, 77.34 APE8-rot-na 21.98 APE67-dihe-in -69.76, -9.03 -50.07, -50.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.097 T790M,L858R,E865A,E866A,K867A None None XRAY 2.7 0.209 0.245 A 331 297 18 0 0 14 [[712, 970]] 1.0 4rj6 Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5EM6A P00533 697 1019 1210.0 5Q3:1102 Type1.5_Back Inactive DFGin 5.878 14.145 BLBminus -133.39, -176.47 60.75, 93.41 -103.35, -152.41 296.39, 89.49 86.46, -35.52 in-in in 8.227 Saltbr-in 2.769 HRD-in -55.67, -47.22 65.49, -1.5 in-in-none SNCiin in-none ActLoopNT-in 2.851 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.38 APE8-dihe-in -86.72, 70.54 APE8-rot-na 29.24 APE67-dihe-in -70.1, -3.7 -44.09, -50.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.233 T790M,L858R,E865A,E866A,K867A None None XRAY 2.78 0.196 0.229 A 331 301 17 0 0 14 [[712, 970]] 1.0 5em6 Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8A2DA P00533 701 1021 1210.0 KXY:1103 Type3 Inactive DFGin 6.285 15.539 BLBminus -141.89, -177.21 45.57, 75.85 -58.33, 149.05 294.71, 179.21 -62.78, 135.74 out-out out 13.017 Saltbr-out 10.523 HRD-in -72.83, -53.94 77.64, -5.69 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.3 APE8-dihe-in -76.96, 68.89 APE8-rot-na 35.24 APE67-dihe-in -71.59, -9.31 -48.88, -43.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.169 L858R,V948R None None XRAY 1.11 0.164 0.179 A 326 281 10 0 0 10 [[712, 970]] 1.0 8a2d Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6P1LB P00533 702 1008 1210.0 ANP:1102 ATPlike Inactive DFGin 4.326 15.477 BLBplus -134.87, 177.11 52.28, 41.66 -92.52, 151.37 118.41, 82.73 79.24, 7.39 out-out out 13.751 Saltbr-out 14.766 HRD-in -69.63, -50.82 67.27, 3.74 out-out-out SNCooo out-out ActLoopNT-out 8.694 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -67.98 APE8-dihe-in -90.55, 79.54 APE8-rot-na 36.74 APE67-dihe-in -76.92, -3.19 -66.82, -38.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.382 T790M,V948R None None XRAY 2.8 0.203 0.237 B 327 292 15 0 0 15 [[712, 970]] 1.0 6p1l Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6WAKA P00533 702 1013 1210.0 ANP:1101 ATPlike Inactive DFGin 3.68 14.038 BLBplus -119.87, 174.58 64.54, 16.96 -69.25, 144.86 73.85, 86.13 77.2, -6.44 out-out out 14.19 Saltbr-out 14.87 HRD-in -68.06, -64.5 89.93, -15.8 out-out-out SNCooo out-out ActLoopNT-out 6.056 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -95.75, -0.13 APE9-dihe-in -104.56, 101.78 APE8-dihe-in -62.85, 69.07 APE8-rot-na 27.65 APE67-dihe-in -73.63, -8.28 -54.79, -35.95 APE12-dist-na 999.0 APE11-dist-na 15.624 APE10-dist-na 11.34 APE9-dist-in 7.772 T790M,V948R None None XRAY 2.4 0.219 0.23 A 328 297 10 0 0 10 [[712, 970]] 1.0 6wak Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6WAKD P00533 701 1014 1210.0 ANP:1101 ATPlike Inactive DFGin 3.881 14.667 BLBplus -128.56, 164.59 71.9, 35.94 -89.47, 146.64 77.53, 95.38 87.93, -24.37 out-out out 13.753 Saltbr-out 11.845 HRD-in -75.5, -62.2 82.94, 0.35 out-out-out SNCooo out-out ActLoopNT-out 6.735 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.69 APE8-dihe-in -82.11, 67.25 APE8-rot-na 35.47 APE67-dihe-in -67.78, -4.44 -51.76, -45.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.046 T790M,V948R None None XRAY 2.4 0.219 0.23 D 328 297 17 0 0 14 [[712, 970]] 1.0 6wak Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8FV3A P00533 701 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 3.96 13.397 BLBplus -132.16, 169.96 65.72, 32.0 -78.17, 140.3 56.84, 82.43 67.0, 6.27 out-out out 13.544 Saltbr-out 14.732 HRD-in -69.71, -62.71 86.1, -12.85 out-out-none SNCoon out-none ActLoopNT-out 6.542 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 27.23 APE9-dihe-in -63.25, 122.03 APE8-dihe-in -75.98, 67.82 APE8-rot-na 29.66 APE67-dihe-in -76.37, -3.74 -56.38, -36.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.726 APE9-dist-in 7.987 T790M,V948R None None XRAY 2.1 0.191 0.226 A 328 299 14 0 0 12 [[712, 970]] 1.0 8fv3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8FV4C P00533 702 1013 1210.0 ANP:1102 ATPlike Inactive DFGin 4.082 13.558 BLBplus -127.73, 168.23 73.07, 11.78 -61.24, 145.82 61.45, 98.91 81.41, -31.2 out-out out 13.742 Saltbr-out 16.115 HRD-in -67.13, -63.64 88.26, -13.01 out-out-out SNCooo out-out ActLoopNT-out 6.584 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -45.21, -49.43 APE9-dihe-in -74.91, 126.99 APE8-dihe-in -76.17, 58.7 APE8-rot-na 28.97 APE67-dihe-in -74.88, -4.9 -52.62, -40.92 APE12-dist-na 999.0 APE11-dist-na 16.262 APE10-dist-na 12.232 APE9-dist-out 8.1 T790M,V948R None None XRAY 2.2 0.204 0.261 C 328 296 11 0 0 11 [[712, 970]] 1.0 8fv4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8TO3B P00533 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 3.657 14.934 BLBplus -134.55, 162.66 68.08, 49.36 -93.73, 164.43 101.15, 105.54 56.1, 2.84 out-out out 13.767 Saltbr-out 13.971 HRD-in -68.15, -46.1 73.95, -11.19 out-out-out SNCooo out-out ActLoopNT-out 6.842 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 106.24 APE8-dihe-in -74.12, 71.61 APE8-rot-na 27.49 APE67-dihe-in -65.2, -1.6 -53.66, -41.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.13 T790M,V948R None None XRAY 2.49 0.231 0.269 B 328 291 18 0 0 13 [[712, 970]] 1.0 8to3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8TO4B P00533 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 4.321 13.838 BLBplus -145.22, 172.21 45.08, 44.37 -91.4, 153.78 67.05, 82.38 64.94, 7.17 out-out out 14.011 Saltbr-out 13.48 HRD-in -63.39, -70.27 96.97, -15.43 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.51 APE8-dihe-in -77.84, 67.96 APE8-rot-na 10.85 APE67-dihe-in -65.93, -24.75 -51.27, -47.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.537 T790M,V948R None None XRAY 2.99 0.176 0.231 B 328 290 18 0 0 14 [[712, 970]] 1.0 8to4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4ZSED P00533 701 1015 1210.0 ANP:4001 ATPlike Inactive DFGin 4.481 13.699 BLBplus -139.61, 164.7 66.53, 26.19 -71.23, 138.48 53.66, 91.47 74.43, 7.23 out-out out 13.877 Saltbr-out 13.686 HRD-in -70.41, -53.51 80.03, -13.83 out-out-none SNCoon out-none ActLoopNT-out 6.522 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.0 APE8-dihe-in -83.67, 68.18 APE8-rot-na 28.71 APE67-dihe-in -64.05, -23.47 -60.9, -39.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.989 T790M,V948R None None XRAY 1.97 0.191 0.213 D 331 297 14 0 0 12 [[712, 970]] 1.0 4zse Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5D41B P00533 701 1014 1210.0 ANP:2001 ATPlike Inactive DFGin 3.946 14.283 BLBplus -122.59, 173.39 56.77, 40.3 -84.43, 150.38 61.52, 86.97 79.88, -36.14 out-out out 13.666 Saltbr-out 11.144 HRD-in -72.27, -56.38 80.95, -10.72 out-out-out SNCooo out-out ActLoopNT-out 6.673 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -30.97 APE9-dihe-in -100.3, 124.18 APE8-dihe-in -72.86, 61.7 APE8-rot-na 30.04 APE67-dihe-in -79.76, 0.67 -51.2, -39.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.501 APE9-dist-out 8.352 T790M,V948R None None XRAY 2.31 0.175 0.207 B 331 302 12 0 0 12 [[712, 970]] 1.0 5d41 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5X2AD P00533 701 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 4.567 13.491 BLBplus -132.47, 164.02 73.22, 18.47 -66.23, 142.03 48.39, 91.71 77.4, 1.26 out-out out 13.992 Saltbr-out 14.35 HRD-in -72.94, -56.49 82.37, -10.91 out-out-out SNCooo out-out ActLoopNT-out 6.463 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 3.06 APE9-dihe-in -69.62, 129.82 APE8-dihe-in -83.4, 65.28 APE8-rot-na 22.72 APE67-dihe-in -72.49, -3.02 -53.67, -40.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.897 APE9-dist-out 8.235 T790M,V948R None None XRAY 1.85 0.176 0.219 D 331 297 13 0 0 10 [[712, 970]] 1.0 5x2a Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXKB P00533 700 1007 1210.0 ANP:1101 ATPlike Inactive DFGin 4.788 14.304 BLBplus -133.99, 169.66 58.32, 39.23 -93.88, 160.42 49.41, 87.38 74.89, 999.0 out-out out 13.49 Saltbr-out 12.394 HRD-in -66.37, -58.14 81.2, -5.32 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.52 APE8-dihe-in -80.54, 72.01 APE8-rot-na 30.24 APE67-dihe-in -73.85, -4.26 -53.45, -45.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.541 T790M,V948R None None XRAY 3.1 0.223 0.261 B 331 290 18 0 0 18 [[712, 970]] 1.0 7jxk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXMC P00533 702 1006 1210.0 ANP:1101 ATPlike Inactive DFGin 4.283 13.994 BLBplus -133.09, 168.24 59.36, 33.1 -80.78, 143.72 58.15, 87.09 66.36, 74.02 out-out out 13.963 Saltbr-out 13.118 HRD-in -67.9, -61.75 83.53, -6.82 out-out-none SNCoon out-none ActLoopNT-out 9.008 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.47 APE8-dihe-in -77.6, 66.96 APE8-rot-na 35.92 APE67-dihe-in -75.2, -5.27 -47.14, -42.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.517 T790M,V948R None None XRAY 2.192 0.228 0.271 C 331 285 20 0 0 15 [[712, 970]] 1.0 7jxm Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5CNOB P00533 698 1015 1210.0 ANP:61001 ATPlike Inactive DFGin 3.889 14.151 BLBplus -128.77, 161.65 68.19, 38.17 -78.09, 143.32 56.13, 92.23 54.89, 36.11 out-out out 13.877 Saltbr-out 12.607 HRD-in -79.53, -48.18 74.57, -9.86 out-out-out SNCooo out-out ActLoopNT-out 8.188 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 114.62 APE9-dihe-in -83.89, 124.6 APE8-dihe-in -81.17, 61.86 APE8-rot-na 30.73 APE67-dihe-in -73.98, -7.26 -47.13, -40.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.092 APE9-dist-out 8.401 V948R None None XRAY 1.55 0.176 0.203 B 330 302 16 0 0 12 [[712, 970]] 1.0 5cno Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5CNNA P00533 699 1014 1210.0 ANP:61101 ATPlike Inactive DFGin 3.97 14.17 BLBplus -125.09, 165.12 65.79, 30.65 -73.26, 142.49 57.23, 92.2 61.04, 28.88 out-out out 14.419 Saltbr-out 11.397 HRD-in -77.1, -52.71 74.61, -9.55 out-out-none SNCoon out-none ActLoopNT-out 8.169 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 61.56 APE9-dihe-in -85.48, 136.67 APE8-dihe-in -75.32, 67.13 APE8-rot-na 28.89 APE67-dihe-in -79.02, -2.66 -49.07, -38.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.997 APE9-dist-in 7.994 I706Q None None XRAY 1.9 0.183 0.211 A 350 300 16 0 0 13 [[712, 970]] 1.0 5cnn Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6P1DB P00533 702 1013 1210.0 ANP:1101,NQ1:1102 ATPlike,Type3 Inactive DFGin 4.737 14.03 BLBplus -133.29, 171.5 64.7, 17.77 -68.3, 145.06 52.12, 92.58 81.65, -14.38 out-out out 13.79 Saltbr-out 14.416 HRD-in -75.11, -58.04 81.02, -12.96 out-out-out SNCooo out-out ActLoopNT-out 6.39 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -53.71 APE8-dihe-in -78.39, 61.97 APE8-rot-na 34.06 APE67-dihe-in -73.46, -6.67 -54.96, -43.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.356 None None None XRAY 2.4 0.195 0.213 B 327 300 12 0 0 12 [[712, 970]] 1.0 6p1d Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6P1LA P00533 701 1007 1210.0 ANP:1102,9LL:1103 ATPlike,Type3 Inactive DFGin 5.09 14.609 BLBplus -137.99, 174.26 51.86, 38.49 -97.68, 160.33 56.12, 79.32 80.95, 13.49 out-out out 13.09 Saltbr-out 11.075 HRD-in -66.81, -53.87 69.64, 3.15 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.91 APE8-dihe-in -92.34, 76.37 APE8-rot-na 35.99 APE67-dihe-in -76.25, -4.78 -68.05, -35.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.361 T790M,V948R None None XRAY 2.8 0.203 0.237 A 327 288 19 0 0 17 [[712, 970]] 1.0 6p1l Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6P1LC P00533 702 1005 1210.0 ANP:1102,9LL:1103 ATPlike,Type3 Inactive DFGin 4.947 14.346 BLBplus -138.12, 175.57 52.19, 39.44 -97.35, 162.11 56.76, 79.57 81.63, 13.51 out-out out 13.069 Saltbr-out 12.69 HRD-in -65.46, -53.47 68.76, 3.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -21.1 APE8-dihe-in -91.14, 76.85 APE8-rot-na 36.16 APE67-dihe-in -74.42, -4.16 -69.53, -34.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.035 T790M,V948R None None XRAY 2.8 0.203 0.237 C 327 280 24 0 0 17 [[712, 970]] 1.0 6p1l Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6P1LD P00533 702 1015 1210.0 ANP:1102,9LL:1103 ATPlike,Type3 Inactive DFGin 5.193 14.634 BLBplus -136.45, 175.46 51.75, 39.49 -96.95, 158.96 56.24, 81.53 81.72, 11.0 out-out out 13.155 Saltbr-out 10.982 HRD-in -66.43, -53.42 65.79, 5.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.86 APE8-dihe-in -92.75, 77.55 APE8-rot-na 35.81 APE67-dihe-in -75.19, -4.23 -67.58, -35.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.094 T790M,V948R None None XRAY 2.8 0.203 0.237 D 327 296 17 0 0 17 [[712, 970]] 1.0 6p1l Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6P8QA P00533 699 1019 1210.0 ANP:2001,O57:2002 ATPlike,Type3 Inactive DFGin 5.291 14.467 BLBplus -136.39, 166.39 65.62, 19.67 -68.64, 141.86 47.45, 96.29 88.91, -15.41 out-out out 13.793 Saltbr-out 13.394 HRD-in -77.48, -60.3 86.7, -15.68 out-out-none SNCoon out-none ActLoopNT-out 6.927 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.69 APE8-dihe-in -82.28, 70.48 APE8-rot-na 31.78 APE67-dihe-in -69.54, -10.7 -59.7, -40.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.523 T790M,V948R None None XRAY 1.9 0.169 0.195 A 327 309 12 0 0 12 [[712, 970]] 1.0 6p8q Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6P8QB P00533 698 1007 1210.0 AMP:2001,O57:2002 ATPlike,Type3 Inactive DFGin 5.276 14.467 BLBplus -135.86, 166.31 67.07, 15.83 -64.3, 136.34 50.27, 96.09 85.52, -9.82 out-out out 13.54 Saltbr-out 13.7 HRD-in -74.24, -59.24 89.14, -20.92 out-out-none SNCoon out-none ActLoopNT-out 6.974 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 150.09 APE9-dihe-in -104.23, 113.6 APE8-dihe-in -82.27, 71.52 APE8-rot-na 22.76 APE67-dihe-in -69.35, -13.24 -58.74, -40.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.877 APE9-dist-in 7.993 T790M,V948R None None XRAY 1.9 0.169 0.195 B 327 300 10 0 0 10 [[712, 970]] 1.0 6p8q Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6P8QC P00533 699 1014 1210.0 AMP:2001,O57:2002 ATPlike,Type3 Inactive DFGin 5.309 14.59 BLBplus -130.27, 166.7 65.36, 18.32 -66.06, 140.33 49.17, 97.15 81.91, -12.21 out-out out 13.83 Saltbr-out 13.591 HRD-in -81.24, -59.54 87.32, -15.78 out-out-in SNCooi out-in ActLoopNT-out 6.911 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.57, 147.96 APE9-dihe-in -130.06, 156.46 APE8-dihe-in -83.94, 74.96 APE8-rot-na 27.22 APE67-dihe-in -70.93, -14.87 -56.96, -36.77 APE12-dist-na 16.927 APE11-dist-na 13.676 APE10-dist-na 14.094 APE9-dist-in 7.721 T790M,V948R None None XRAY 1.9 0.169 0.195 C 327 316 0 0 0 0 [[712, 970]] 1.0 6p8q Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6P8QD P00533 700 1007 1210.0 AMP:2001,O57:2002 ATPlike,Type3 Inactive DFGin 5.367 14.316 BLBplus -131.89, 166.57 70.0, 15.99 -68.19, 140.48 43.77, 99.15 83.83, -10.13 out-out out 13.426 Saltbr-out 13.149 HRD-in -73.29, -58.03 87.0, -17.51 out-out-none SNCoon out-none ActLoopNT-out 6.894 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 92.37 APE8-dihe-in -76.46, 76.63 APE8-rot-na 30.25 APE67-dihe-in -71.2, -11.99 -56.02, -38.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.449 T790M,V948R None None XRAY 1.9 0.169 0.195 D 327 296 12 0 0 12 [[712, 970]] 1.0 6p8q Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6XL4D P00533 700 1013 1210.0 ANP:1102,NQ1:1103 ATPlike,Type3 Inactive DFGin 4.89 14.247 BLBplus -133.2, 175.82 65.76, 18.85 -77.15, 145.6 52.8, 92.59 74.56, -2.19 out-out out 13.624 Saltbr-out 15.83 HRD-in -71.69, -57.79 76.59, -4.88 out-out-none SNCoon out-none ActLoopNT-out 6.478 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.17 APE8-dihe-in -78.79, 71.74 APE8-rot-na 31.74 APE67-dihe-in -74.38, -1.99 -55.71, -41.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.77 T790M,V948R None None XRAY 2.06 0.216 0.252 D 328 300 14 0 0 11 [[712, 970]] 1.0 6xl4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8TO4C P00533 702 1013 1210.0 ANP:1102,IXR:1103 ATPlike,Type3 Inactive DFGin 5.324 14.703 BLBplus -141.27, 171.12 64.77, 53.38 -109.59, 167.64 42.74, 100.72 59.4, 999.0 out-out out 13.294 Saltbr-out 12.35 HRD-in -63.29, -59.94 84.01, 4.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.05 APE8-dihe-in -90.09, 61.93 APE8-rot-na 21.85 APE67-dihe-in -81.47, -6.07 -53.96, -24.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.836 T790M,V948R None None XRAY 2.99 0.176 0.231 C 328 289 18 0 0 18 [[712, 970]] 1.0 8to4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8TO4D P00533 702 1005 1210.0 ANP:1102,IXR:1103 ATPlike,Type3 Inactive DFGin 4.551 14.188 BLBplus -127.27, 157.13 78.08, 44.22 -85.23, -172.29 38.08, 100.01 106.69, 999.0 out-out out 13.656 Saltbr-out 10.825 HRD-in -72.87, -44.75 69.45, -7.84 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 105.73 APE8-dihe-in -81.92, 60.79 APE8-rot-na 34.7 APE67-dihe-in -66.67, -11.33 -39.66, -48.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.66 T790M,V948R None None XRAY 2.99 0.176 0.231 D 328 283 20 0 0 18 [[712, 970]] 1.0 8to4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5D41A P00533 698 1014 1210.0 ANP:1102,57N:1103 ATPlike,Type3 Inactive DFGin 4.968 14.448 BLBplus -130.27, 169.23 61.95, 37.88 -93.29, 173.71 50.74, 86.35 79.65, -10.55 out-out out 12.815 Saltbr-out 11.374 HRD-in -77.25, -55.76 78.51, -14.31 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 155.57 APE8-dihe-in -80.12, 74.82 APE8-rot-na 31.53 APE67-dihe-in -75.45, -3.11 -51.46, -43.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8 T790M,V948R None None XRAY 2.31 0.175 0.207 A 331 300 17 0 0 17 [[712, 970]] 1.0 5d41 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6DUKA P00533 701 1006 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.416 14.801 BLBplus -133.89, 165.03 66.94, 37.08 -93.36, 166.29 58.42, 86.37 91.91, 6.11 out-out out 13.918 Saltbr-out 14.179 HRD-in -76.73, -64.87 85.37, -18.97 out-out-out SNCooo out-out ActLoopNT-out 7.438 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.39, -10.84 APE9-dihe-in -125.5, 116.79 APE8-dihe-in -80.16, 76.04 APE8-rot-na 31.69 APE67-dihe-in -76.14, -1.34 -58.18, -44.83 APE12-dist-na 17.364 APE11-dist-na 15.202 APE10-dist-na 11.776 APE9-dist-in 7.311 T790M,V948R None None XRAY 2.2 0.191 0.223 A 331 306 0 0 0 0 [[712, 970]] 1.0 6duk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6DUKB P00533 699 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.681 14.65 BLBplus -136.44, 165.42 61.83, 36.22 -89.54, 161.73 53.44, 89.67 90.48, 19.39 out-out out 13.812 Saltbr-out 14.733 HRD-in -68.48, -61.78 82.94, -15.18 out-out-none SNCoon out-none ActLoopNT-out 7.292 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.53 APE8-dihe-in -76.17, 63.91 APE8-rot-na 26.99 APE67-dihe-in -79.83, -2.27 -51.77, -41.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.922 T790M,V948R None None XRAY 2.2 0.191 0.223 B 331 296 13 0 0 13 [[712, 970]] 1.0 6duk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6DUKC P00533 699 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.661 14.391 BLBplus -137.36, 170.05 61.14, 32.95 -87.42, 165.36 52.89, 84.68 86.51, 15.0 out-out out 13.749 Saltbr-out 12.387 HRD-in -66.04, -61.2 80.35, -9.27 out-out-none SNCoon out-none ActLoopNT-out 8.286 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.92 APE8-dihe-in -77.64, 67.39 APE8-rot-na 32.93 APE67-dihe-in -71.69, -8.16 -55.72, -42.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.823 T790M,V948R None None XRAY 2.2 0.191 0.223 C 331 295 14 0 0 14 [[712, 970]] 1.0 6duk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6DUKD P00533 701 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.605 14.634 BLBplus -137.83, 165.45 65.63, 29.61 -82.3, 167.28 56.12, 84.13 94.16, 13.47 out-out out 14.053 Saltbr-out 14.886 HRD-in -74.03, -57.71 81.46, -18.53 out-out-out SNCooo out-out ActLoopNT-out 7.321 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -76.03, 11.31 APE9-dihe-in -134.89, 121.24 APE8-dihe-in -86.59, 77.19 APE8-rot-na 34.21 APE67-dihe-in -72.84, -7.51 -59.65, -43.13 APE12-dist-na 17.747 APE11-dist-na 15.555 APE10-dist-na 11.903 APE9-dist-in 7.539 T790M,V948R None None XRAY 2.2 0.191 0.223 D 331 307 0 0 0 0 [[712, 970]] 1.0 6duk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6DUKE P00533 698 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.706 14.387 BLBplus -132.31, 167.27 63.11, 42.82 -102.17, 159.55 52.62, 85.09 88.84, 16.78 out-out out 13.768 Saltbr-out 14.361 HRD-in -70.33, -59.21 85.76, -23.74 out-out-none SNCoon out-none ActLoopNT-out 7.686 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 1.83 APE9-dihe-in -127.74, 112.92 APE8-dihe-in -68.38, 64.27 APE8-rot-na 21.48 APE67-dihe-in -73.72, -8.33 -52.7, -41.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.291 APE9-dist-in 7.941 T790M,V948R None None XRAY 2.2 0.191 0.223 E 331 298 12 0 0 12 [[712, 970]] 1.0 6duk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6DUKF P00533 701 1009 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.653 14.612 BLBplus -133.82, 164.75 63.96, 32.85 -83.32, 163.7 53.83, 93.49 88.31, 19.42 out-out out 14.108 Saltbr-out 15.144 HRD-in -67.38, -62.37 88.35, -19.9 out-out-none SNCoon out-none ActLoopNT-out 7.319 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.72 APE8-dihe-in -80.72, 70.63 APE8-rot-na 32.98 APE67-dihe-in -75.6, -2.87 -62.49, -36.24 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.841 T790M,V948R None None XRAY 2.2 0.191 0.223 F 331 298 11 0 0 11 [[712, 970]] 1.0 6duk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXKD P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.861 14.45 BLBplus -134.29, 170.65 60.11, 37.92 -95.07, 160.21 48.8, 86.41 74.63, 26.88 out-out out 13.457 Saltbr-out 11.763 HRD-in -66.46, -59.56 80.54, -6.1 out-out-none SNCoon out-none ActLoopNT-out 8.903 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.41 APE8-dihe-in -81.29, 71.57 APE8-rot-na 30.4 APE67-dihe-in -73.66, -4.05 -53.54, -44.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.472 T790M,V948R None None XRAY 3.1 0.223 0.261 D 331 294 14 0 0 14 [[712, 970]] 1.0 7jxk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXMD P00533 700 1007 1210.0 ANP:1101,9LL:1103 ATPlike,Type3 Inactive DFGin 4.952 14.337 BLBplus -135.28, 170.25 61.86, 31.57 -85.27, 155.14 53.77, 85.22 78.23, 19.31 out-out out 13.049 Saltbr-out 11.894 HRD-in -66.52, -63.02 84.71, -6.37 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.04 APE8-dihe-in -80.42, 66.88 APE8-rot-na 32.97 APE67-dihe-in -76.05, -3.45 -51.47, -42.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.762 T790M,V948R None None XRAY 2.192 0.228 0.271 D 331 291 17 0 0 17 [[712, 970]] 1.0 7jxm Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXPA P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.747 14.617 BLBplus -136.18, 166.76 64.66, 34.04 -92.53, 168.9 56.02, 85.41 85.63, 11.86 out-out out 13.988 Saltbr-out 14.307 HRD-in -74.54, -64.28 89.28, -17.63 out-out-out SNCooo out-out ActLoopNT-out 7.509 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.63, -15.8 APE9-dihe-in -113.05, 126.54 APE8-dihe-in -83.29, 68.9 APE8-rot-na 33.94 APE67-dihe-in -74.36, -3.96 -52.3, -47.62 APE12-dist-na 17.096 APE11-dist-na 14.956 APE10-dist-na 11.693 APE9-dist-in 7.406 T790M,V948R None None XRAY 2.16 0.214 0.247 A 331 308 0 0 0 0 [[712, 970]] 1.0 7jxp Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXPB P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.671 14.511 BLBplus -135.21, 165.17 64.35, 37.85 -90.15, 169.17 53.82, 91.67 84.59, 7.68 out-out out 13.756 Saltbr-out 13.888 HRD-in -70.65, -63.17 87.36, -17.28 out-out-out SNCooo out-out ActLoopNT-out 7.592 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.44, -17.16 APE9-dihe-in -126.66, 129.43 APE8-dihe-in -78.52, 67.74 APE8-rot-na 34.72 APE67-dihe-in -76.32, -3.64 -51.52, -45.13 APE12-dist-na 17.438 APE11-dist-na 15.214 APE10-dist-na 12.275 APE9-dist-in 7.617 T790M,V948R None None XRAY 2.16 0.214 0.247 B 331 308 0 0 0 0 [[712, 970]] 1.0 7jxp Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXPD P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.766 14.661 BLBplus -135.69, 167.35 65.6, 33.96 -89.97, 168.72 55.6, 87.2 84.96, 9.82 out-out out 13.526 Saltbr-out 11.283 HRD-in -71.06, -65.03 87.13, -14.24 out-out-none SNCoon out-none ActLoopNT-out 8.004 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.01 APE8-dihe-in -77.89, 69.26 APE8-rot-na 33.29 APE67-dihe-in -74.9, -2.69 -52.27, -42.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.744 T790M,V948R None None XRAY 2.16 0.214 0.247 D 331 294 14 0 0 14 [[712, 970]] 1.0 7jxp Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXPF P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.974 14.702 BLBplus -136.82, 166.82 61.14, 36.57 -93.57, 171.83 53.4, 92.66 83.03, -0.51 out-out out 13.674 Saltbr-out 11.57 HRD-in -71.01, -63.71 87.17, -13.68 out-out-none SNCoon out-none ActLoopNT-out 9.118 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.33 APE8-dihe-in -78.62, 69.48 APE8-rot-na 32.72 APE67-dihe-in -72.69, -4.28 -52.16, -45.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.621 T790M,V948R None None XRAY 2.16 0.214 0.247 F 331 294 14 0 0 14 [[712, 970]] 1.0 7jxp Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXQB P00533 701 1007 1210.0 ANP:1102,VNS:1103 ATPlike,Type3 Inactive DFGin 4.915 14.438 BLBplus -136.8, 171.78 58.87, 35.86 -91.33, 162.29 51.51, 87.21 80.67, 16.0 out-out out 13.335 Saltbr-out 12.698 HRD-in -67.21, -58.71 77.88, -12.51 out-out-none SNCoon out-none ActLoopNT-out 8.896 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -177.71 APE9-dihe-in -105.47, 135.84 APE8-dihe-in -83.2, 67.78 APE8-rot-na 33.37 APE67-dihe-in -74.22, -7.65 -49.73, -41.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.734 APE9-dist-in 7.645 T790M,V948R None None XRAY 1.83 0.185 0.218 B 331 297 10 0 0 10 [[712, 970]] 1.0 7jxq Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXQD P00533 700 1007 1210.0 ANP:1102,VNS:1103 ATPlike,Type3 Inactive DFGin 4.844 14.328 BLBplus -136.14, 172.56 58.98, 36.18 -92.84, 162.13 51.55, 88.05 79.36, 17.26 out-out out 13.42 Saltbr-out 11.89 HRD-in -65.12, -58.0 78.92, -12.53 out-out-none SNCoon out-none ActLoopNT-out 8.94 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.09 APE8-dihe-in -80.19, 68.24 APE8-rot-na 33.29 APE67-dihe-in -74.77, -5.19 -50.69, -44.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.579 T790M,V948R None None XRAY 1.83 0.185 0.218 D 331 298 10 0 0 10 [[712, 970]] 1.0 7jxq Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7LTXA P00533 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.248 14.564 BLBplus -135.35, 163.04 64.03, 33.94 -82.37, 179.4 48.16, 87.26 -162.42, -162.89 out-out out 13.182 Saltbr-out 10.599 HRD-in -67.02, -61.48 82.46, -5.8 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.93 APE8-dihe-in -80.94, 68.72 APE8-rot-na 31.43 APE67-dihe-in -70.18, -9.53 -51.9, -44.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.02 T790M,V948R None None XRAY 2.3 0.187 0.216 A 331 292 16 0 0 16 [[712, 970]] 1.0 7ltx Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7LTXB P00533 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.197 14.495 BLBplus -136.17, 169.66 62.42, 34.77 -78.22, 170.05 42.44, 90.17 -152.16, -165.64 out-out out 13.123 Saltbr-out 10.226 HRD-in -65.63, -61.11 82.51, -6.05 out-out-none SNCoon out-none ActLoopNT-out 9.239 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.13 APE8-dihe-in -82.01, 66.41 APE8-rot-na 31.46 APE67-dihe-in -73.58, -7.26 -49.71, -42.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.829 T790M,V948R None None XRAY 2.3 0.187 0.216 B 331 293 15 0 0 15 [[712, 970]] 1.0 7ltx Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7LTXC P00533 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.123 14.511 BLBplus -136.55, 165.71 63.6, 32.17 -87.45, 156.27 46.73, 94.27 148.1, 156.05 out-out out 13.071 Saltbr-out 10.076 HRD-in -65.09, -59.89 81.29, -6.26 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.8 APE8-dihe-in -79.63, 67.92 APE8-rot-na 31.3 APE67-dihe-in -72.94, -5.81 -52.93, -44.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.864 T790M,V948R None None XRAY 2.3 0.187 0.216 C 331 292 16 0 0 16 [[712, 970]] 1.0 7ltx Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7LTXD P00533 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.346 14.443 BLBplus -137.08, 165.99 63.56, 34.05 -81.77, 167.16 44.82, 94.68 -177.57, 165.83 out-out out 12.986 Saltbr-out 10.34 HRD-in -68.33, -62.57 83.39, -4.99 out-out-none SNCoon out-none ActLoopNT-out 9.494 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.9 APE8-dihe-in -80.86, 67.56 APE8-rot-na 30.12 APE67-dihe-in -73.23, -5.97 -50.49, -42.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.917 T790M,V948R None None XRAY 2.3 0.187 0.216 D 331 293 15 0 0 15 [[712, 970]] 1.0 7ltx Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8GB4A P00533 700 1007 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.738 14.778 BLBplus -140.96, 174.92 57.37, 44.23 -99.53, 158.98 50.67, 86.24 74.62, 16.37 out-out out 13.355 Saltbr-out 11.698 HRD-in -69.91, -59.18 79.33, -9.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.01 APE8-dihe-in -76.27, 67.14 APE8-rot-na 30.24 APE67-dihe-in -75.65, -5.48 -58.37, -41.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.058 T790M,V948R None None XRAY 2.59 0.23 0.254 A 331 292 16 0 0 16 [[712, 970]] 1.0 8gb4 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8GB4B P00533 700 1007 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.858 14.681 BLBplus -140.61, 174.15 57.09, 43.59 -100.33, 162.57 51.99, 86.76 77.41, 18.84 out-out out 13.39 Saltbr-out 10.531 HRD-in -69.24, -58.17 79.24, -10.08 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.16 APE8-rot-na 30.06 APE67-dihe-in -75.09, -5.85 -58.81, -39.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 2.59 0.23 0.254 B 331 290 18 0 0 18 [[712, 970]] 1.0 8gb4 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8GB4C P00533 700 1012 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.732 14.602 BLBplus -141.16, 174.43 57.44, 44.8 -99.46, 158.79 49.11, 85.48 74.36, 22.53 out-out out 13.185 Saltbr-out 11.537 HRD-in -70.07, -59.0 77.64, -8.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.65 APE8-dihe-in -76.99, 66.94 APE8-rot-na 30.24 APE67-dihe-in -75.42, -5.6 -59.05, -41.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.014 T790M,V948R None None XRAY 2.59 0.23 0.254 C 331 297 16 0 0 16 [[712, 970]] 1.0 8gb4 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8GB4D P00533 700 1007 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.686 14.698 BLBplus -141.21, 175.0 57.29, 43.49 -99.79, 159.92 51.61, 87.18 76.57, 22.15 out-out out 13.561 Saltbr-out 10.91 HRD-in -69.19, -58.43 79.07, -10.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 65.97 APE8-rot-na 30.21 APE67-dihe-in -74.96, -5.48 -59.31, -40.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 2.59 0.23 0.254 D 331 291 17 0 0 17 [[712, 970]] 1.0 8gb4 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7K1IA P00533 700 1007 1210.0 ANP:1102,VNS:1103 ATPlike,Type3 Inactive DFGin 4.837 14.412 BLBplus -124.92, 173.52 55.34, 38.4 -93.27, 168.4 51.69, 86.03 70.99, 11.24 out-out out 13.596 Saltbr-out 12.212 HRD-in -68.02, -55.76 76.66, -7.58 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.86 APE8-dihe-in -84.0, 73.03 APE8-rot-na 29.2 APE67-dihe-in -72.27, -9.54 -58.41, -42.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.42 L858R,V948R None None XRAY 3.202 0.266 0.311 A 331 288 20 0 0 17 [[712, 970]] 1.0 7k1i Homo sapiens TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6WXNA P00533 699 1014 1210.0 No_ligand No_ligand Inactive DFGin 4.853 14.024 BLBplus -126.21, 168.87 69.17, 33.07 -82.8, 162.03 48.79, 88.7 44.39, 44.22 out-out out 13.115 Saltbr-out 12.745 HRD-in -70.78, -60.03 85.71, -15.47 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.13 APE8-dihe-in -86.46, 71.73 APE8-rot-na 36.97 APE67-dihe-in -76.26, -5.03 -50.8, -39.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.133 T790M,V948R None None XRAY 1.76 0.209 0.235 A 328 298 16 0 0 16 [[712, 970]] 1.0 6wxn Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7UKWA P00533 702 1014 1210.0 No_ligand No_ligand Inactive DFGin 3.581 13.829 BLBplus -128.6, 172.3 69.85, 12.86 -66.14, 147.6 72.2, 96.6 82.34, -29.23 out-out out 13.797 Saltbr-out 13.846 HRD-in -71.25, -59.42 83.42, -8.1 out-out-out SNCooo out-out ActLoopNT-out 6.712 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -76.18, -16.76 APE9-dihe-in -80.09, 122.05 APE8-dihe-in -79.83, 67.74 APE8-rot-na 31.37 APE67-dihe-in -79.14, 0.49 -56.49, -38.64 APE12-dist-na 18.86 APE11-dist-na 16.017 APE10-dist-na 11.421 APE9-dist-in 7.829 T790M,V948R None None XRAY 2.6 0.198 0.25 A 328 306 2 0 0 2 [[712, 970]] 1.0 7ukw Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7TVDA P00533 698 1009 1210.0 No_ligand No_ligand Inactive DFGin 4.431 14.232 BLBplus -146.5, 168.0 61.48, 51.23 -104.55, 142.32 34.5, 86.81 71.61, 13.83 in-out in 7.927 Saltbr-out 4.135 HRD-in -70.54, -56.96 76.98, -3.53 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.89 APE8-dihe-in -84.43, 67.37 APE8-rot-na 26.32 APE67-dihe-in -72.01, -9.76 -63.46, -35.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.453 None None None XRAY 2.96 0.242 0.277 A 335 292 16 0 0 16 [[712, 970]] 1.0 7tvd Homo sapiens TYR_EGFR_HUMAN TYR 2.7e-84 288.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5ZTOA P00533 697 1017 1210.0 9JO:1101 Type1 Inactive DFGin 4.655 14.859 BLBplus -130.18, 175.35 63.93, 30.88 -101.94, 137.29 49.3, 91.62 80.58, 29.83 in-in in 8.509 Saltbr-in 2.925 HRD-in -69.78, -52.43 69.58, -8.35 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 37.71 APE8-rot-na 39.97 APE67-dihe-in -56.49, -26.37 -64.04, -33.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,C797S None None XRAY 2.649 0.234 0.272 A 331 294 19 0 0 17 [[712, 970]] 1.0 5zto Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V66D P00533 701 1014 1210.0 QP1:1203 Type1 Inactive DFGin 4.096 13.943 BLBplus -133.25, 173.78 71.02, 17.1 -71.48, 143.37 58.07, 94.52 76.41, -7.86 out-out out 14.093 Saltbr-out 14.181 HRD-in -71.49, -55.9 81.36, -15.85 out-out-out SNCooo out-out ActLoopNT-out 6.527 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -93.31, -7.02 APE9-dihe-in -100.17, 123.42 APE8-dihe-in -79.15, 63.8 APE8-rot-na 32.12 APE67-dihe-in -77.89, -1.58 -50.41, -43.42 APE12-dist-na 18.544 APE11-dist-na 16.043 APE10-dist-na 11.737 APE9-dist-in 7.947 T790M,V948R None None XRAY 1.79 0.187 0.226 D 327 314 0 0 0 0 [[712, 970]] 1.0 6v66 Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V6KA P00533 700 1014 1210.0 QQJ:1202 Type1 Inactive DFGin 3.867 13.844 BLBplus -126.62, 172.08 72.11, 17.73 -68.46, 144.29 67.31, 94.55 80.98, -14.27 out-out out 14.069 Saltbr-out 13.117 HRD-in -76.25, -55.46 78.72, -10.68 out-out-none SNCoon out-none ActLoopNT-out 6.607 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.92 APE8-dihe-in -90.83, 73.86 APE8-rot-na 33.95 APE67-dihe-in -71.2, -5.54 -52.83, -43.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.981 T790M,V948R None None XRAY 2.2 0.215 0.239 A 327 300 13 0 0 13 [[712, 970]] 1.0 6v6k Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V6KC P00533 700 1014 1210.0 QQJ:1202 Type1 Inactive DFGin 3.742 14.114 BLBplus -126.65, 174.74 68.29, 24.91 -77.8, 144.03 65.82, 93.11 70.95, 0.99 out-out out 14.113 Saltbr-out 13.32 HRD-in -74.46, -61.55 88.29, -10.53 out-out-none SNCoon out-none ActLoopNT-out 6.895 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.13 APE8-dihe-in -80.16, 64.39 APE8-rot-na 34.44 APE67-dihe-in -74.67, -2.44 -48.42, -47.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.908 T790M,V948R None None XRAY 2.2 0.215 0.239 C 327 302 13 0 0 13 [[712, 970]] 1.0 6v6k Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V6KD P00533 701 1014 1210.0 QQJ:1202 Type1 Inactive DFGin 3.349 14.94 BLBplus -117.8, 170.46 73.04, 20.38 -74.63, 149.6 91.38, 90.72 79.09, -12.98 out-out out 13.99 Saltbr-out 13.446 HRD-in -72.66, -55.83 84.51, -14.82 out-out-out SNCooo out-out ActLoopNT-out 6.713 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.51, 1.42 APE9-dihe-in -116.89, 115.01 APE8-dihe-in -75.54, 67.0 APE8-rot-na 30.88 APE67-dihe-in -77.85, 1.7 -51.8, -42.48 APE12-dist-na 17.569 APE11-dist-na 15.006 APE10-dist-na 10.889 APE9-dist-in 7.789 T790M,V948R None None XRAY 2.2 0.215 0.239 D 327 314 0 0 0 0 [[712, 970]] 1.0 6v6k Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V6KF P00533 701 1014 1210.0 QQJ:1202 Type1 Inactive DFGin 3.98 13.825 BLBplus -120.93, 173.29 72.83, 17.47 -73.23, 142.03 63.46, 93.26 87.26, -10.56 out-out out 13.994 Saltbr-out 13.923 HRD-in -64.5, -59.24 85.68, -12.32 out-out-out SNCooo out-out ActLoopNT-out 6.808 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -89.94, 8.75 APE9-dihe-in -116.9, 120.13 APE8-dihe-in -80.85, 65.83 APE8-rot-na 33.37 APE67-dihe-in -73.94, -2.38 -51.14, -44.1 APE12-dist-na 18.149 APE11-dist-na 15.602 APE10-dist-na 11.467 APE9-dist-out 8.143 T790M,V948R None None XRAY 2.2 0.215 0.239 F 327 306 8 0 0 8 [[712, 970]] 1.0 6v6k Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V6KG P00533 701 1014 1210.0 QQJ:1202 Type1 Inactive DFGin 3.875 13.95 BLBplus -130.73, 172.58 73.14, 20.78 -75.62, 138.08 60.03, 93.12 84.61, -15.28 out-out out 14.036 Saltbr-out 14.615 HRD-in -71.13, -52.8 79.1, -13.85 out-out-out SNCooo out-out ActLoopNT-out 6.47 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.69, -0.28 APE9-dihe-in -105.61, 125.6 APE8-dihe-in -80.99, 60.63 APE8-rot-na 33.61 APE67-dihe-in -75.24, -7.52 -47.39, -44.79 APE12-dist-na 18.186 APE11-dist-na 15.859 APE10-dist-na 11.416 APE9-dist-in 7.933 T790M,V948R None None XRAY 2.2 0.215 0.239 G 327 314 0 0 0 0 [[712, 970]] 1.0 6v6k Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V6OC P00533 701 1011 1210.0 QQM:1202 Type1 Inactive DFGin 3.644 14.214 BLBplus -122.87, 171.43 70.23, 18.79 -66.69, 140.71 67.25, 92.35 81.97, -11.3 out-out out 14.261 Saltbr-out 13.537 HRD-in -75.21, -54.45 82.69, -13.83 out-out-out SNCooo out-out ActLoopNT-out 6.78 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.15 APE8-dihe-in -81.1, 67.37 APE8-rot-na 31.91 APE67-dihe-in -73.98, -4.02 -53.95, -44.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.276 T790M,V948R None None XRAY 2.1 0.196 0.221 C 327 297 12 0 0 12 [[712, 970]] 1.0 6v6o Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V6OD P00533 701 1014 1210.0 QQM:1202 Type1 Inactive DFGin 3.863 14.109 BLBplus -124.4, 171.55 69.25, 17.62 -67.5, 139.98 64.11, 93.51 81.27, -10.57 out-out out 14.298 Saltbr-out 13.561 HRD-in -74.72, -54.65 82.6, -12.74 out-out-out SNCooo out-out ActLoopNT-out 6.694 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.63, -11.25 APE9-dihe-in -98.47, 121.43 APE8-dihe-in -79.76, 67.8 APE8-rot-na 32.25 APE67-dihe-in -74.09, -4.64 -53.64, -43.16 APE12-dist-na 18.514 APE11-dist-na 15.909 APE10-dist-na 11.537 APE9-dist-in 7.999 T790M,V948R None None XRAY 2.1 0.196 0.221 D 327 314 0 0 0 0 [[712, 970]] 1.0 6v6o Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V6OE P00533 701 1014 1210.0 QQM:1202 Type1 Inactive DFGin 3.762 14.126 BLBplus -123.9, 171.7 69.62, 18.55 -66.64, 139.7 64.92, 95.49 81.38, -10.3 out-out out 14.01 Saltbr-out 14.506 HRD-in -75.07, -55.34 81.99, -12.92 out-out-none SNCoon out-none ActLoopNT-out 6.897 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -28.58 APE9-dihe-in -100.13, 119.03 APE8-dihe-in -80.06, 70.49 APE8-rot-na 32.0 APE67-dihe-in -73.71, -4.57 -52.25, -42.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.853 APE9-dist-in 7.834 T790M,V948R None None XRAY 2.1 0.196 0.221 E 327 303 11 0 0 11 [[712, 970]] 1.0 6v6o Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V6OH P00533 700 1014 1210.0 QQM:1202 Type1 Inactive DFGin 3.651 13.984 BLBplus -123.38, 171.8 70.53, 19.82 -66.37, 140.7 65.92, 91.26 79.41, -10.87 out-out out 13.699 Saltbr-out 12.865 HRD-in -75.67, -55.2 81.77, -12.73 out-out-none SNCoon out-none ActLoopNT-out 6.85 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -16.84 APE9-dihe-in -111.7, 114.25 APE8-dihe-in -84.18, 71.19 APE8-rot-na 31.92 APE67-dihe-in -73.23, -5.03 -51.26, -41.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.228 APE9-dist-in 7.798 T790M,V948R None None XRAY 2.1 0.196 0.221 H 327 299 11 0 0 11 [[712, 970]] 1.0 6v6o Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V5NA P00533 701 1014 1210.0 QP7:1101 Type1 Inactive DFGin 3.874 14.043 BLBplus -131.86, 170.73 72.76, 5.92 -62.08, 148.09 69.53, 94.27 88.44, -36.3 out-out out 13.696 Saltbr-out 14.382 HRD-in -69.73, -62.04 88.23, -15.47 out-out-out SNCooo out-out ActLoopNT-out 6.764 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 81.73, -91.94 APE9-dihe-in -62.41, 118.62 APE8-dihe-in -74.09, 69.5 APE8-rot-na 30.39 APE67-dihe-in -79.22, -7.19 -56.4, -40.52 APE12-dist-na 19.113 APE11-dist-na 16.022 APE10-dist-na 12.476 APE9-dist-in 7.932 T790M,V948R None None XRAY 2.4 0.194 0.243 A 328 314 0 0 0 0 [[712, 970]] 1.0 6v5n Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V5PA P00533 701 1014 1210.0 QP4:1101 Type1 Inactive DFGin 4.083 13.904 BLBplus -131.2, 176.01 67.46, 19.27 -70.58, 141.95 55.96, 94.52 75.39, -7.99 out-out out 14.12 Saltbr-out 13.869 HRD-in -75.98, -55.78 84.58, -17.4 out-out-out SNCooo out-out ActLoopNT-out 6.727 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -68.57, -1.97 APE9-dihe-in -106.2, 124.29 APE8-dihe-in -83.08, 63.06 APE8-rot-na 33.31 APE67-dihe-in -79.73, -4.58 -50.4, -37.06 APE12-dist-na 17.954 APE11-dist-na 15.473 APE10-dist-na 10.923 APE9-dist-in 7.812 T790M,V948R None None XRAY 2.3 0.18 0.194 A 328 314 0 0 0 0 [[712, 970]] 1.0 6v5p Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXLB P00533 700 1005 1210.0 VO7:1101 Type1 Inactive DFGin 5.246 13.632 BLBplus -132.57, 173.49 63.97, 37.87 -98.02, 155.82 53.78, 87.52 97.69, 168.21 out-out out 13.274 Saltbr-out 10.365 HRD-in -68.45, -55.65 82.41, -9.47 out-out-none SNCoon out-none ActLoopNT-out 11.071 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.84 APE8-dihe-in -79.09, 72.8 APE8-rot-na 32.94 APE67-dihe-in -75.09, -2.58 -53.56, -42.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.945 T790M,V948R None None XRAY 2.4 0.21 0.239 B 331 285 15 0 0 15 [[712, 970]] 1.0 7jxl Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXLC P00533 700 1007 1210.0 VO7:1101 Type1 Inactive DFGin 5.046 14.21 BLBplus -131.44, 169.42 60.64, 42.48 -100.4, 172.86 57.82, 96.69 101.73, -98.55 out-out out 13.295 Saltbr-out 10.82 HRD-in -68.59, -57.74 83.98, -10.65 out-out-out SNCooo out-out ActLoopNT-out 8.773 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.84 APE8-dihe-in -84.48, 72.12 APE8-rot-na 33.75 APE67-dihe-in -77.24, -3.14 -52.76, -40.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.068 T790M,V948R None None XRAY 2.4 0.21 0.239 C 331 292 16 0 0 14 [[712, 970]] 1.0 7jxl Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXLD P00533 700 1007 1210.0 VO7:1101 Type1 Inactive DFGin 5.173 13.928 BLBplus -133.7, 169.87 61.73, 43.83 -103.39, 170.74 58.35, 94.82 87.82, 34.82 out-out out 13.626 Saltbr-out 11.064 HRD-in -67.75, -57.45 83.8, -10.92 out-out-none SNCoon out-none ActLoopNT-out 9.169 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 68.84 APE8-rot-na 32.75 APE67-dihe-in -76.98, -2.85 -51.41, -42.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 2.4 0.21 0.239 D 331 292 16 0 0 16 [[712, 970]] 1.0 7jxl Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7KY0A P00533 701 1007 1210.0 XA4:1101 Type1 Inactive DFGin 4.934 13.72 BLBplus -141.11, -177.29 64.89, 51.57 -115.71, 120.75 54.84, 96.01 152.25, 35.37 out-out out 13.485 Saltbr-out 12.212 HRD-in -66.11, -56.54 81.78, -10.06 out-out-none SNCoon out-none ActLoopNT-out 8.644 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.15 APE8-dihe-in -82.92, 73.8 APE8-rot-na 32.47 APE67-dihe-in -76.16, -2.99 -59.22, -41.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.733 T790M,V948R None None XRAY 3.1 0.24 0.292 A 331 288 14 0 0 14 [[712, 970]] 1.0 7ky0 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6TFYA P00533 699 982 1210.0 N7Z:1101 Type1 Inactive DFGin 4.097 14.31 BLBplus -125.48, -177.34 63.89, 37.21 -107.03, 143.92 80.58, 98.31 105.92, 8.7 out-out out 14.098 Saltbr-out 12.905 HRD-in -73.28, -55.39 77.03, -6.83 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 105.38 APE9-dihe-in -67.96, 130.83 APE8-dihe-in -78.11, 63.29 APE8-rot-na 31.69 APE67-dihe-in -71.25, -7.27 -55.57, -39.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.72 APE9-dist-out 8.124 T790M,V948R None None XRAY 1.7 0.193 0.212 A 333 266 18 0 0 15 [[712, 970]] 1.0 6tfy Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7A6JB P00533 699 984 1210.0 R2E:1101 Type1 Inactive DFGin 5.458 13.796 BLBplus -144.25, -179.46 65.49, 29.82 -99.51, 152.89 65.46, 98.76 73.1, -125.3 out-out out 13.459 Saltbr-out 10.998 HRD-in -71.08, -55.82 83.36, -14.67 out-out-out SNCooo out-out ActLoopNT-out 9.376 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -57.31 APE8-dihe-in -78.95, 60.24 APE8-rot-na 32.73 APE67-dihe-in -71.17, -11.35 -55.28, -40.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.728 T790M,V948R None None XRAY 2.0 0.192 0.216 B 333 271 15 0 0 15 [[712, 970]] 1.0 7a6j Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7ZYQA P00533 700 984 1210.0 V58:1101 Type1 Inactive DFGin 5.351 14.039 BLBplus -126.85, 173.6 59.25, 54.42 -119.93, 159.99 65.54, 96.87 75.52, -19.59 out-none out 14.29 Saltbr-none 999.0 HRD-in -75.55, -54.64 81.44, -14.09 none-out-out SNCnoo out-out ActLoopNT-out 7.214 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 113.44 APE8-dihe-in -82.18, 68.98 APE8-rot-na 30.56 APE67-dihe-in -72.77, -5.68 -55.78, -43.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.137 T790M,V948R None None XRAY 2.1 0.199 0.223 A 333 270 15 0 0 15 [[712, 970]] 1.0 7zyq Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5FEEA P00533 697 1018 1210.0 5X4:1101 Type1 Inactive DFGin 4.52 13.749 BLBplus -148.22, -167.33 40.92, 69.1 -115.76, 70.34 31.37, 65.2 -71.51, -22.89 in-in in 8.791 Saltbr-in 3.318 HRD-in -72.57, -51.63 72.54, -3.53 in-in-out SNCiio in-out ActLoopNT-in 3.044 ActLoopCT-out TYR APEdihe_iioao APEdist_aaai APE10-dihe-in -61.11, 145.12 APE9-dihe-in -133.91, 152.17 APE8-dihe-out -65.95, -32.07 APE8-rot-na 335.9 APE67-dihe-out -78.14, -18.7 66.26, -53.45 APE12-dist-na 11.21 APE11-dist-na 8.385 APE10-dist-na 10.2 APE9-dist-in 6.967 T790M None None XRAY 2.7 0.192 0.229 A 328 287 14 0 0 5 [[712, 970]] 1.0 5fee Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5GTYA P00533 700 1014 1210.0 816:1101 Type1 Inactive DFGin 3.919 14.254 BLBplus -136.6, 160.21 83.79, 10.32 -71.62, 130.12 75.47, 69.3 84.21, -2.08 out-out out 14.11 Saltbr-out 15.158 HRD-in -64.26, -47.89 82.5, -11.45 out-out-none SNCoon out-none ActLoopNT-out 7.176 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 130.2 APE9-dihe-in -65.39, 157.4 APE8-dihe-in -83.63, 78.13 APE8-rot-na 34.93 APE67-dihe-in -61.71, -42.12 -62.97, -39.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 15.408 APE9-dist-in 7.816 T790M None None XRAY 3.14 0.258 0.28 A 331 300 15 0 0 11 [[712, 970]] 1.0 5gty Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5GTYC P00533 700 1013 1210.0 816:1101 Type1 Inactive DFGin 4.284 15.817 BLBplus -149.79, 169.46 71.39, 12.4 -62.83, 164.89 105.62, 48.04 58.84, -127.22 out-out out 13.78 Saltbr-out 14.402 HRD-in -63.98, -44.78 76.23, -10.44 out-out-none SNCoon out-none ActLoopNT-out 8.843 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -4.61 APE8-rot-na 27.64 APE67-dihe-in -61.37, -42.92 -62.91, -38.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M None None XRAY 3.14 0.258 0.28 C 331 295 19 0 0 15 [[712, 970]] 1.0 5gty Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5GTYF P00533 700 1013 1210.0 816:1101 Type1 Inactive DFGin 4.566 15.591 BLBplus -143.69, 172.87 60.29, 35.9 -98.19, 125.74 96.55, 67.96 83.35, -2.23 out-none out 14.169 Saltbr-none 999.0 HRD-out -91.66, 107.92 -65.69, -38.43 none-out-out SNCnoo out-out ActLoopNT-out 6.102 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -163.83 APE8-dihe-in -84.57, 72.91 APE8-rot-na 22.97 APE67-dihe-in -62.3, -42.82 -63.85, -40.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.491 T790M None None XRAY 3.14 0.258 0.28 F 331 297 17 0 0 13 [[712, 970]] 1.0 5gty Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6XL4A P00533 700 1007 1210.0 Q6K:1301,NQ1:1302 Type1,Type3 Inactive DFGin 5.098 14.695 BLBplus -134.42, 176.69 66.92, 16.35 -78.69, 146.78 51.46, 92.89 75.99, 3.76 out-out out 13.363 Saltbr-out 12.539 HRD-in -71.16, -58.13 77.59, -5.31 out-out-none SNCoon out-none ActLoopNT-out 7.386 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.31 APE8-dihe-in -78.15, 72.0 APE8-rot-na 31.9 APE67-dihe-in -74.09, -1.62 -55.44, -42.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.703 T790M,V948R None None XRAY 2.06 0.216 0.252 A 328 293 15 0 0 15 [[712, 970]] 1.0 6xl4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXKA P00533 700 1007 1210.0 8BS:1101,JBJ:1102 Type1,Type3 Inactive DFGin 4.862 14.824 BLBplus -134.12, 169.24 58.43, 39.5 -93.7, 161.51 49.25, 87.25 75.0, 16.23 out-out out 13.778 Saltbr-out 10.461 HRD-in -66.55, -57.53 81.35, -6.11 out-out-none SNCoon out-none ActLoopNT-out 8.816 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.68 APE8-dihe-in -81.09, 70.58 APE8-rot-na 30.58 APE67-dihe-in -73.21, -4.24 -54.1, -46.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.489 T790M,V948R None None XRAY 3.1 0.223 0.261 A 331 293 15 0 0 15 [[712, 970]] 1.0 7jxk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXKC P00533 701 1007 1210.0 8BS:1101,JBJ:1102 Type1,Type3 Inactive DFGin 4.503 14.594 BLBplus -134.13, 170.52 59.34, 39.88 -92.58, 159.61 51.08, 87.14 75.55, 20.71 out-out out 13.608 Saltbr-out 11.925 HRD-in -66.31, -58.5 79.98, -6.68 out-out-none SNCoon out-none ActLoopNT-out 8.44 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.55 APE8-dihe-in -81.28, 70.99 APE8-rot-na 30.58 APE67-dihe-in -73.05, -5.14 -53.98, -44.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.444 T790M,V948R None None XRAY 3.1 0.223 0.261 C 331 292 15 0 0 15 [[712, 970]] 1.0 7jxk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXKE P00533 700 1007 1210.0 8BS:1101,JBJ:1102 Type1,Type3 Inactive DFGin 4.893 14.488 BLBplus -134.7, 170.02 59.73, 38.84 -95.72, 161.23 49.85, 87.39 75.41, 21.47 out-out out 13.509 Saltbr-out 11.783 HRD-in -66.69, -59.11 80.54, -6.15 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.43 APE8-dihe-in -79.83, 71.88 APE8-rot-na 29.74 APE67-dihe-in -73.96, -4.52 -53.36, -45.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.534 T790M,V948R None None XRAY 3.1 0.223 0.261 E 331 287 16 0 0 16 [[712, 970]] 1.0 7jxk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXKF P00533 700 1007 1210.0 8BS:1101,JBJ:1102 Type1,Type3 Inactive DFGin 4.872 14.387 BLBplus -134.77, 169.91 59.08, 39.36 -94.94, 160.87 49.89, 87.34 75.14, 17.06 out-out out 13.528 Saltbr-out 12.787 HRD-in -66.88, -58.5 80.33, -5.79 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.79 APE8-dihe-in -81.39, 71.1 APE8-rot-na 29.52 APE67-dihe-in -73.84, -5.2 -54.64, -45.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.478 T790M,V948R None None XRAY 3.1 0.223 0.261 F 331 292 16 0 0 16 [[712, 970]] 1.0 7jxk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXMB P00533 701 1012 1210.0 YY3:1101,9LL:1102 Type1,Type3 Inactive DFGin 5.155 14.648 BLBplus -133.95, 169.04 59.67, 39.65 -96.16, 166.65 49.37, 86.58 68.24, 16.57 out-out out 13.166 Saltbr-out 10.454 HRD-in -67.1, -62.37 83.6, -7.78 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.13 APE8-dihe-in -90.39, 74.47 APE8-rot-na 39.92 APE67-dihe-in -71.29, -11.25 -51.45, -39.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.779 T790M,V948R None None XRAY 2.192 0.228 0.271 B 331 296 16 0 0 16 [[712, 970]] 1.0 7jxm Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXWA P00533 700 1007 1210.0 YY3:1301,VNS:1302 Type1,Type3 Inactive DFGin 4.579 14.666 BLBplus -138.64, 168.46 50.29, 44.7 -88.71, 170.77 52.75, 84.47 69.65, 17.94 out-out out 13.177 Saltbr-out 9.933 HRD-in -64.27, -62.7 83.56, -10.71 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -29.5 APE8-dihe-in -90.52, 58.97 APE8-rot-na 25.71 APE67-dihe-in -73.18, -5.87 -63.78, -37.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.655 T790M,V948R None None XRAY 2.5 0.276 0.319 A 331 288 20 0 0 16 [[712, 970]] 1.0 7jxw Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXWB P00533 700 1007 1210.0 YY3:1301,VNS:1302 Type1,Type3 Inactive DFGin 4.889 14.548 BLBplus -137.39, 167.04 52.05, 48.78 -89.33, 172.11 49.0, 84.75 70.86, 14.53 out-out out 12.88 Saltbr-out 9.64 HRD-in -63.98, -61.04 82.53, -9.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.58 APE8-rot-na 26.38 APE67-dihe-in -75.13, -4.52 -61.59, -34.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 2.5 0.276 0.319 B 331 291 17 0 0 17 [[712, 970]] 1.0 7jxw Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXWC P00533 700 1007 1210.0 YY3:1301,VNS:1302 Type1,Type3 Inactive DFGin 4.644 14.309 BLBplus -142.67, 169.6 56.07, 43.83 -87.93, 169.01 48.26, 81.62 68.95, 14.82 out-out out 13.394 Saltbr-out 10.06 HRD-in -68.52, -63.21 83.53, -10.12 out-out-none SNCoon out-none ActLoopNT-out 9.372 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.99 APE8-dihe-in -72.85, 69.17 APE8-rot-na 25.57 APE67-dihe-in -79.13, -5.07 -61.58, -38.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.741 T790M,V948R None None XRAY 2.5 0.276 0.319 C 331 293 15 0 0 15 [[712, 970]] 1.0 7jxw Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXWD P00533 700 1007 1210.0 YY3:1301,VNS:1302 Type1,Type3 Inactive DFGin 4.474 14.215 BLBplus -140.27, 167.25 54.64, 43.57 -89.93, 170.58 53.09, 83.38 70.73, 14.16 out-out out 13.287 Saltbr-out 10.176 HRD-in -66.78, -61.63 83.28, -9.7 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.01 APE8-dihe-in -78.05, 71.87 APE8-rot-na 25.04 APE67-dihe-in -75.98, -6.06 -65.38, -38.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.012 T790M,V948R None None XRAY 2.5 0.276 0.319 D 331 287 21 0 0 17 [[712, 970]] 1.0 7jxw Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8GK5A P00533 701 1011 1210.0 Q6K:1101,YW5:1102 Type1,Type3 Inactive DFGin 4.808 14.912 BLBplus -132.77, 163.28 59.53, 50.36 -94.02, 166.24 50.17, 88.29 66.49, 24.24 out-out out 13.127 Saltbr-out 9.96 HRD-in -72.38, -54.99 79.4, -8.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.66 APE8-dihe-in -80.77, 69.75 APE8-rot-na 32.13 APE67-dihe-in -76.82, -3.31 -58.55, -37.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.087 T790M,V948R None None XRAY 2.3 0.224 0.252 A 331 294 17 0 0 17 [[712, 970]] 1.0 8gk5 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8GK5B P00533 700 1008 1210.0 Q6K:1101,YW5:1102 Type1,Type3 Inactive DFGin 4.513 14.722 BLBplus -133.17, 164.36 59.73, 51.31 -91.4, 162.53 47.93, 87.21 64.33, 22.83 out-out out 13.093 Saltbr-out 12.438 HRD-in -72.73, -55.9 79.15, -8.43 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.91 APE8-dihe-in -79.02, 69.83 APE8-rot-na 32.01 APE67-dihe-in -76.26, -3.86 -58.1, -38.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.867 T790M,V948R None None XRAY 2.3 0.224 0.252 B 331 292 17 0 0 17 [[712, 970]] 1.0 8gk5 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8GK5C P00533 700 1008 1210.0 Q6K:1101,YW5:1102 Type1,Type3 Inactive DFGin 4.465 14.758 BLBplus -134.6, 164.78 60.76, 50.7 -93.92, 162.62 46.93, 87.83 64.54, 21.99 out-out out 13.135 Saltbr-out 11.494 HRD-in -72.37, -55.98 79.27, -6.85 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.09 APE8-dihe-in -76.74, 68.64 APE8-rot-na 31.76 APE67-dihe-in -75.53, -4.34 -59.95, -38.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.102 T790M,V948R None None XRAY 2.3 0.224 0.252 C 331 293 16 0 0 16 [[712, 970]] 1.0 8gk5 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8GK5D P00533 700 1008 1210.0 Q6K:1101,YW5:1102 Type1,Type3 Inactive DFGin 4.407 14.729 BLBplus -134.17, 163.98 61.67, 51.99 -93.03, 163.58 47.55, 87.87 65.01, 22.54 out-out out 13.091 Saltbr-out 12.29 HRD-in -70.88, -54.33 77.76, -8.04 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -1.54 APE9-dihe-in -75.57, 134.88 APE8-dihe-in -77.01, 71.98 APE8-rot-na 32.06 APE67-dihe-in -76.98, -3.79 -58.78, -38.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.721 APE9-dist-in 7.558 T790M,V948R None None XRAY 2.3 0.224 0.252 D 331 294 15 0 0 15 [[712, 970]] 1.0 8gk5 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6Z4BA P00533 700 982 1210.0 Q6K:1101,9LL:1102 Type1,Type3 Inactive DFGin 5.693 14.816 BLBplus -133.89, 164.94 59.43, 51.96 -98.19, 144.81 41.57, 85.88 67.58, 19.62 out-none out 14.398 Saltbr-none 999.0 HRD-in -67.89, -64.09 87.77, -27.23 none-out-out SNCnoo out-out ActLoopNT-out 7.141 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -2.64 APE9-dihe-in -120.02, 130.13 APE8-dihe-in -80.9, 78.34 APE8-rot-na 31.39 APE67-dihe-in -73.81, -4.61 -60.28, -41.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.71 APE9-dist-out 8.134 T790M,V948R None None XRAY 2.5 0.222 0.251 A 333 271 12 0 0 12 [[712, 970]] 1.0 6z4b Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6Z4BB P00533 699 984 1210.0 Q6K:1101,9LL:1102 Type1,Type3 Inactive DFGin 6.233 14.529 BLBplus -131.04, 166.01 60.41, 49.56 -101.97, 145.48 42.99, 86.21 -89.28, 999.0 out-out out 12.903 Saltbr-out 9.732 HRD-out -138.19, 95.22 -83.97, -17.5 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.87 APE8-dihe-in -88.45, 76.4 APE8-rot-na 32.2 APE67-dihe-in -72.84, -5.09 -59.16, -39.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.257 T790M,V948R None None XRAY 2.5 0.222 0.251 B 333 263 23 0 0 18 [[712, 970]] 1.0 6z4b Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6Z4DB P00533 700 984 1210.0 8BS:1101,57N:1102 Type1,Type3 Inactive DFGin 5.216 14.759 BLBplus -130.83, 169.9 60.42, 43.34 -92.85, 149.61 47.56, 91.66 72.77, 15.07 out-none out 13.458 Saltbr-none 999.0 HRD-in -75.42, -54.52 82.84, -20.67 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 176.11 APE9-dihe-in -119.54, 129.26 APE8-dihe-in -76.04, 63.14 APE8-rot-na 30.86 APE67-dihe-in -72.75, -5.66 -53.62, -40.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.675 APE9-dist-out 8.425 T790M,V948R None None XRAY 2.0 0.195 0.221 B 333 270 15 0 0 15 [[712, 970]] 1.0 6z4d Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5GNKA P00533 697 985 1210.0 80U:1001 Type1.5_Back Inactive DFGin 4.567 13.546 BLBplus -124.44, 160.99 73.54, 15.52 -61.64, 132.87 35.67, 94.83 87.34, -10.68 out-out out 12.136 Saltbr-out 9.468 HRD-in -71.44, -52.43 80.32, -11.88 out-out-out SNCooo out-out ActLoopNT-out 6.772 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 164.79 APE8-dihe-in -85.69, 72.36 APE8-rot-na 30.12 APE67-dihe-in -71.32, -14.07 -58.84, -38.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.046 T790M None None XRAY 1.796 0.166 0.177 A 297 277 12 0 0 12 [[712, 970]] 1.0 5gnk Homo sapiens TYR_EGFR_HUMAN TYR 5.7e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6WA2A P00533 699 1014 1210.0 TOV:1301 Type1.5_Back Inactive DFGin 4.044 14.259 BLBplus -130.21, 167.87 66.28, 28.26 -71.53, 137.79 56.13, 92.64 79.92, -10.79 out-out out 14.2 Saltbr-out 14.276 HRD-in -69.18, -54.46 82.51, -21.52 out-out-out SNCooo out-out ActLoopNT-out 6.808 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.16 APE8-dihe-in -69.52, 73.28 APE8-rot-na 28.29 APE67-dihe-in -78.42, 2.09 -58.73, -42.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.176 T790M,V948R None None XRAY 2.4 0.222 0.258 A 328 302 12 0 0 12 [[712, 970]] 1.0 6wa2 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6WA2B P00533 701 1014 1210.0 TOV:1202 Type1.5_Back Inactive DFGin 3.853 14.507 BLBplus -130.44, 170.54 68.6, 27.89 -72.96, 137.09 58.49, 93.15 78.78, -11.36 out-out out 14.62 Saltbr-out 15.92 HRD-in -69.14, -54.27 84.16, -20.91 out-out-out SNCooo out-out ActLoopNT-out 7.16 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.22, -29.83 APE9-dihe-in -89.49, 122.81 APE8-dihe-in -80.98, 72.1 APE8-rot-na 32.79 APE67-dihe-in -78.49, 1.16 -58.92, -42.99 APE12-dist-na 17.625 APE11-dist-na 15.041 APE10-dist-na 11.119 APE9-dist-in 7.835 T790M,V948R None None XRAY 2.4 0.222 0.258 B 328 314 0 0 0 0 [[712, 970]] 1.0 6wa2 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6WA2C P00533 701 1014 1210.0 TOV:1202 Type1.5_Back Inactive DFGin 3.59 15.223 BLBplus -129.9, 169.08 66.72, 27.67 -72.33, 138.28 81.68, 95.17 77.09, -11.93 out-out out 14.51 Saltbr-out 14.952 HRD-in -68.93, -54.81 83.12, -20.03 out-out-none SNCoon out-none ActLoopNT-out 6.51 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.6 APE8-dihe-in -75.46, 75.31 APE8-rot-na 31.12 APE67-dihe-in -77.15, 1.55 -57.9, -41.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.744 T790M,V948R None None XRAY 2.4 0.222 0.258 C 328 300 14 0 0 12 [[712, 970]] 1.0 6wa2 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6WA2D P00533 701 1014 1210.0 TOV:1301 Type1.5_Back Inactive DFGin 4.037 14.22 BLBplus -130.83, 170.13 66.86, 27.29 -72.91, 137.99 57.49, 89.24 79.84, -11.2 out-out out 14.143 Saltbr-out 16.135 HRD-in -67.86, -54.75 83.33, -19.28 out-out-out SNCooo out-out ActLoopNT-out 6.745 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -72.34, 16.66 APE9-dihe-in -119.43, 121.09 APE8-dihe-in -82.59, 71.16 APE8-rot-na 32.34 APE67-dihe-in -79.04, 1.4 -59.51, -42.07 APE12-dist-na 18.026 APE11-dist-na 15.504 APE10-dist-na 11.15 APE9-dist-in 7.966 T790M,V948R None None XRAY 2.4 0.222 0.258 D 328 314 0 0 0 0 [[712, 970]] 1.0 6wa2 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8FV3C P00533 701 1009 1210.0 YA6:1101 Type1.5_Back Inactive DFGin 4.976 14.226 BLBplus -140.28, 173.45 62.97, 49.98 -100.77, 147.39 44.76, 100.07 103.45, -165.1 out-out out 13.733 Saltbr-out 12.977 HRD-in -73.54, -54.95 81.69, -9.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 112.62 APE8-dihe-in -78.9, 67.7 APE8-rot-na 28.92 APE67-dihe-in -74.17, -1.93 -55.66, -42.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.207 T790M,V948R None None XRAY 2.1 0.191 0.226 C 328 291 18 0 0 17 [[712, 970]] 1.0 8fv3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8FV4D P00533 701 1005 1210.0 YAA:1101 Type1.5_Back Inactive DFGin 4.336 14.193 BLBplus -131.61, 167.63 65.73, 30.81 -71.32, 133.31 54.39, 91.6 84.61, 0.99 out-out out 13.944 Saltbr-out 12.433 HRD-in -68.84, -58.76 79.63, -1.53 out-out-none SNCoon out-none ActLoopNT-out 7.083 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 100.68 APE8-dihe-in -73.69, 77.18 APE8-rot-na 31.74 APE67-dihe-in -70.65, -4.38 -67.28, -33.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.815 T790M,V948R None None XRAY 2.2 0.204 0.261 D 328 291 14 0 0 13 [[712, 970]] 1.0 8fv4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6TFUA P00533 700 982 1210.0 N7K:1101 Type1.5_Back Inactive DFGin 4.427 13.864 BLBplus -130.16, 178.36 62.49, 31.16 -91.67, 140.32 64.62, 97.35 77.86, -17.11 out-out out 13.801 Saltbr-out 13.446 HRD-in -77.96, -51.4 79.0, -10.47 out-out-none SNCoon out-none ActLoopNT-out 8.182 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 113.15 APE8-dihe-in -73.63, 74.24 APE8-rot-na 30.82 APE67-dihe-in -74.45, -5.59 -56.1, -39.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.884 T790M,V948R None None XRAY 2.0 0.203 0.233 A 333 267 16 0 0 14 [[712, 970]] 1.0 6tfu Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6TFVA P00533 700 985 1210.0 N7Q:1101 Type1.5_Back Inactive DFGin 4.801 14.042 BLBplus -127.87, 178.85 65.5, 33.25 -100.08, 161.84 66.11, 92.22 81.21, -6.69 out-none out 14.097 Saltbr-none 999.0 HRD-in -73.79, -54.39 81.21, -13.14 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 112.65 APE9-dihe-in -63.36, 128.89 APE8-dihe-in -78.52, 63.85 APE8-rot-na 34.33 APE67-dihe-in -76.0, -5.3 -53.35, -39.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.172 APE9-dist-in 7.816 T790M,V948R None None XRAY 1.5 0.184 0.203 A 333 269 17 0 0 16 [[712, 970]] 1.0 6tfv Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6TFVB P00533 698 984 1210.0 N7Q:1105 Type1.5_Back Inactive DFGin 5.909 13.504 BLBplus -133.27, -177.3 66.71, 50.83 -134.53, -174.0 59.0, 89.26 81.06, -19.59 out-out out 13.563 Saltbr-out 12.152 HRD-in -76.67, -54.7 81.14, -9.97 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 145.82 APE9-dihe-in -98.3, 131.12 APE8-dihe-in -80.76, 67.11 APE8-rot-na 33.5 APE67-dihe-in -76.31, -4.36 -54.19, -40.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 16.478 APE9-dist-in 7.975 T790M,V948R None None XRAY 1.5 0.184 0.203 B 333 268 19 0 0 16 [[712, 970]] 1.0 6tfv Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6TFWA P00533 700 982 1210.0 N7W:1101 Type1.5_Back Inactive DFGin 4.787 14.107 BLBplus -132.64, 176.54 61.0, 25.14 -85.77, 143.95 61.55, 92.16 66.16, 16.86 out-out out 13.947 Saltbr-out 13.149 HRD-in -74.82, -54.24 72.68, 8.63 out-out-none SNCoon out-none ActLoopNT-out 8.163 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -86.61 APE9-dihe-in -122.2, 137.57 APE8-dihe-in -75.44, 74.31 APE8-rot-na 30.35 APE67-dihe-in -70.83, -4.37 -56.59, -44.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.952 APE9-dist-in 7.42 T790M,V948R None None XRAY 2.0 0.224 0.245 A 333 266 17 0 0 14 [[712, 970]] 1.0 6tfw Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6TFWB P00533 700 984 1210.0 N7W:1105 Type1.5_Back Inactive DFGin 5.473 13.953 BLBplus -136.84, -176.85 60.1, 54.53 -129.66, 147.25 61.08, 91.4 89.61, 999.0 out-out out 13.675 Saltbr-out 11.805 HRD-in -71.22, -49.17 82.6, -11.99 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 110.05 APE8-dihe-in -75.27, 77.65 APE8-rot-na 29.93 APE67-dihe-in -72.87, -8.08 -59.24, -42.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.022 T790M,V948R None None XRAY 2.0 0.224 0.245 B 333 264 21 0 0 18 [[712, 970]] 1.0 6tfw Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6TFYB P00533 699 984 1210.0 N7Z:1104 Type1.5_Back Inactive DFGin 5.537 13.915 BLBplus -129.47, -176.79 65.55, 50.72 -133.13, 168.46 63.91, 95.78 94.18, 6.69 out-out out 13.522 Saltbr-out 11.964 HRD-in -72.76, -56.5 77.72, -7.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.32 APE8-dihe-in -81.35, 62.3 APE8-rot-na 33.43 APE67-dihe-in -71.59, -7.13 -54.96, -40.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.37 T790M,V948R None None XRAY 1.7 0.193 0.212 B 333 264 22 0 0 17 [[712, 970]] 1.0 6tfy Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6TFZA P00533 701 982 1210.0 N7B:1101 Type1.5_Back Inactive DFGin 4.81 14.039 BLBplus -131.17, 176.76 66.24, 32.71 -90.96, 157.66 58.34, 95.96 78.65, -5.02 out-none out 13.738 Saltbr-none 999.0 HRD-in -73.66, -52.65 76.67, -10.13 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 62.7 APE9-dihe-in -78.68, 135.58 APE8-dihe-in -80.74, 62.33 APE8-rot-na 36.82 APE67-dihe-in -73.76, -8.98 -52.23, -40.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.266 APE9-dist-in 7.991 T790M,V948R None None XRAY 1.8 0.176 0.206 A 333 264 18 0 0 16 [[712, 970]] 1.0 6tfz Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6TFZB P00533 700 984 1210.0 N7B:1101 Type1.5_Back Inactive DFGin 5.918 13.336 BLBplus -137.17, -171.23 63.4, 43.24 -124.37, 167.57 57.63, 93.3 72.74, -129.39 out-none out 13.556 Saltbr-none 999.0 HRD-in -71.16, -57.76 83.58, -14.25 none-out-none SNCnon out-none ActLoopNT-out 9.804 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 154.49 APE8-dihe-in -82.81, 72.07 APE8-rot-na 33.88 APE67-dihe-in -76.45, -4.79 -54.88, -38.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.708 T790M,V948R None None XRAY 1.8 0.176 0.206 B 333 271 14 0 0 14 [[712, 970]] 1.0 6tfz Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6TG0A P00533 700 985 1210.0 N78:1101 Type1.5_Back Inactive DFGin 5.751 14.369 BLBplus -135.18, -174.71 67.55, 51.68 -142.66, 170.72 64.3, 92.15 77.6, 999.0 out-out out 14.056 Saltbr-out 12.766 HRD-in -71.97, -56.05 80.78, -8.56 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.61 APE8-dihe-in -78.26, 65.34 APE8-rot-na 35.68 APE67-dihe-in -76.24, -6.42 -52.05, -40.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.566 T790M,V948R None None XRAY 1.5 0.174 0.188 A 333 267 19 0 0 18 [[712, 970]] 1.0 6tg0 Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6TG0B P00533 698 984 1210.0 N78:1105 Type1.5_Back Inactive DFGin 6.259 13.66 BLBplus -137.8, -176.41 66.01, 56.66 -142.67, 173.28 62.89, 93.05 72.69, -137.17 out-out out 13.47 Saltbr-out 11.795 HRD-in -71.39, -56.76 81.41, -11.24 out-out-none SNCoon out-none ActLoopNT-out 9.898 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -3.99 APE9-dihe-in -123.88, 117.15 APE8-dihe-in -83.72, 66.18 APE8-rot-na 34.91 APE67-dihe-in -75.21, -6.99 -52.62, -41.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.935 APE9-dist-in 7.36 T790M,V948R None None XRAY 1.5 0.174 0.188 B 333 276 11 0 0 11 [[712, 970]] 1.0 6tg0 Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6TG1A P00533 699 984 1210.0 N82:1101 Type1.5_Back Inactive DFGin 5.884 14.313 BLBplus -135.09, -174.82 67.14, 52.49 -145.29, 161.02 65.35, 90.59 96.92, 999.0 out-out out 14.061 Saltbr-out 13.148 HRD-in -73.8, -54.65 80.6, -11.14 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.01 APE8-dihe-in -83.61, 66.82 APE8-rot-na 36.14 APE67-dihe-in -74.2, -5.59 -56.71, -41.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.347 T790M,V948R None None XRAY 1.6 0.182 0.198 A 333 268 18 0 0 18 [[712, 970]] 1.0 6tg1 Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6TG1B P00533 698 984 1210.0 N82:1101 Type1.5_Back Inactive DFGin 5.972 14.365 BLBplus -131.9, -167.09 65.39, 54.65 -153.53, 171.0 69.57, 91.23 106.74, -17.72 out-none out 13.59 Saltbr-none 999.0 HRD-in -72.65, -58.62 83.23, 2.46 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.94 APE8-dihe-in -81.28, 62.75 APE8-rot-na 33.22 APE67-dihe-in -73.65, -5.87 -52.25, -41.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.307 T790M,V948R None None XRAY 1.6 0.182 0.198 B 333 271 16 0 0 16 [[712, 970]] 1.0 6tg1 Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2JIVB P00533 699 982 1210.0 HKI:1797 Type1.5_Back Inactive DFGin 5.077 13.748 BLBplus -147.04, -173.33 50.03, 19.5 -76.15, 164.05 47.98, 89.4 34.92, 16.92 out-out out 14.258 Saltbr-out 14.063 HRD-in -76.44, -8.74 29.89, 32.3 out-out-out SNCooo out-out ActLoopNT-out 6.582 ActLoopCT-out TYR APEdihe_ooiai APEdist_aaao APE10-dihe-out -61.7, 27.79 APE9-dihe-out -57.93, -177.94 APE8-dihe-in -111.79, 65.27 APE8-rot-na 347.45 APE67-dihe-in -88.48, -47.11 -56.32, 0.62 APE12-dist-na 15.291 APE11-dist-na 15.522 APE10-dist-na 14.783 APE9-dist-out 8.197 T790M None None XRAY 3.5 0.253 0.284 B 328 272 12 0 0 11 [[712, 970]] 1.0 2jiv Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5GTYB P00533 700 1014 1210.0 816:1101 Type1.5_Back Inactive DFGin 4.29 14.347 BLBplus -138.92, 165.68 84.63, 3.85 -68.43, 135.48 78.45, 90.03 81.71, -3.27 out-out out 13.492 Saltbr-out 15.599 HRD-out -95.29, 124.61 -62.89, -41.97 out-out-out SNCooo out-out ActLoopNT-out 7.06 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -99.53 APE9-dihe-in -66.19, 150.26 APE8-dihe-in -83.76, 84.04 APE8-rot-na 28.01 APE67-dihe-in -63.91, -38.81 -63.74, -37.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.154 APE9-dist-out 9.305 T790M None None XRAY 3.14 0.258 0.28 B 331 299 16 0 0 12 [[712, 970]] 1.0 5gty Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5GTYD P00533 701 1014 1210.0 816:1101 Type1.5_Back Inactive DFGin 3.744 14.902 BLBplus -133.78, 167.12 81.14, 4.97 -64.51, 133.85 87.51, 89.95 82.67, -5.26 out-out out 14.125 Saltbr-out 12.581 HRD-in -64.22, -47.55 79.94, -12.61 out-out-out SNCooo out-out ActLoopNT-out 6.18 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 35.49 APE9-dihe-in -128.38, 151.23 APE8-dihe-in -84.12, 67.79 APE8-rot-na 27.63 APE67-dihe-in -63.81, -37.49 -62.48, -38.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.155 APE9-dist-out 8.324 T790M None None XRAY 3.14 0.258 0.28 D 331 297 17 0 0 12 [[712, 970]] 1.0 5gty Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5GTYE P00533 701 1014 1210.0 816:1101 Type1.5_Back Inactive DFGin 4.06 15.401 BLBplus -130.28, 163.95 73.19, 13.87 -64.73, 129.08 103.21, 59.68 78.99, -3.66 out-none out 13.741 Saltbr-none 999.0 HRD-in -63.53, -39.57 73.37, -57.08 none-out-out SNCnoo out-out ActLoopNT-out 5.679 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -16.57 APE9-dihe-in -63.24, 143.82 APE8-dihe-in -84.53, 69.95 APE8-rot-na 27.95 APE67-dihe-in -63.25, -38.96 -61.88, -39.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.901 APE9-dist-out 9.111 T790M None None XRAY 3.14 0.258 0.28 E 331 297 17 0 0 12 [[712, 970]] 1.0 5gty Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5GTYG P00533 699 1014 1210.0 816:1101 Type1.5_Back Inactive DFGin 5.067 14.626 BLBplus -143.11, 179.85 58.12, 44.59 -112.54, 128.63 59.94, 74.31 85.4, 3.0 out-out out 14.3 Saltbr-out 16.006 HRD-in -64.4, -40.83 72.49, -56.78 out-out-out SNCooo out-out ActLoopNT-out 7.055 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 152.17 APE9-dihe-in -112.88, 128.29 APE8-dihe-in -84.62, 80.89 APE8-rot-na 19.82 APE67-dihe-in -63.68, -40.43 -63.75, -39.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.262 APE9-dist-out 9.052 T790M None None XRAY 3.14 0.258 0.28 G 331 299 17 0 0 12 [[712, 970]] 1.0 5gty Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5GTYH P00533 700 1016 1210.0 816:1101 Type1.5_Back Inactive DFGin 4.464 14.996 BLBplus -155.19, 174.62 58.89, 40.9 -106.98, 132.32 74.94, 82.26 87.03, 0.91 out-out out 14.092 Saltbr-out 15.791 HRD-in -64.35, -48.45 80.9, -10.31 out-out-out SNCooo out-out ActLoopNT-out 6.834 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 6.3 APE9-dihe-in -114.67, 127.92 APE8-dihe-in -87.4, 86.48 APE8-rot-na 29.16 APE67-dihe-in -62.99, -38.55 -63.72, -40.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.525 APE9-dist-out 8.734 T790M None None XRAY 3.14 0.258 0.28 H 331 300 16 0 0 12 [[712, 970]] 1.0 5gty Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3W2RA P00533 698 1017 1210.0 W2R:1101 Type1.5_Back Inactive DFGin 4.449 12.33 BLBplus -137.59, 178.08 54.95, 38.03 -65.53, 155.88 47.33, 82.4 -65.44, 174.26 out-out out 11.302 Saltbr-out 9.806 HRD-in -74.49, -53.66 81.5, -16.32 out-out-none SNCoon out-none ActLoopNT-out 7.869 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.04 APE8-dihe-in -78.09, 65.46 APE8-rot-na 29.85 APE67-dihe-in -79.31, 0.09 -47.47, -44.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.899 T790M,L858R None None XRAY 2.05 0.22 0.275 A 331 297 14 0 0 14 [[712, 970]] 1.0 3w2r Homo sapiens TYR_EGFR_HUMAN TYR 8.7e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2RGPA P00533 702 1016 1210.0 HYZ:1 Type1.5_Back Inactive DFGin 4.639 13.972 BLBplus -140.95, 177.84 65.47, 21.11 -77.76, 153.7 43.68, 94.35 83.07, -34.52 out-out out 13.729 Saltbr-out 12.982 HRD-in -65.03, -54.97 78.42, -10.72 out-out-none SNCoon out-none ActLoopNT-out 6.364 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.81 APE8-dihe-in -76.74, 62.82 APE8-rot-na 346.55 APE67-dihe-in -70.49, -6.2 -47.73, -43.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.962 None None None XRAY 2.0 0.228 0.268 A 315 284 17 0 0 8 [[712, 970]] 1.0 2rgp Homo sapiens TYR_EGFR_HUMAN TYR 9.2e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3BELA P00533 702 1015 1210.0 POX:1 Type1.5_Back Inactive DFGin 4.429 13.975 BLBplus -144.0, 174.65 70.44, 15.84 -72.96, 152.06 48.87, 90.91 82.19, -30.43 out-out out 13.888 Saltbr-out 13.489 HRD-in -59.26, -60.02 83.7, -7.04 out-out-none SNCoon out-none ActLoopNT-out 6.315 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.28 APE8-dihe-in -78.06, 64.55 APE8-rot-na 39.14 APE67-dihe-in -67.84, -7.09 -49.38, -46.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.992 None None None XRAY 2.3 0.241 0.281 A 315 280 18 0 0 8 [[712, 970]] 1.0 3bel Homo sapiens TYR_EGFR_HUMAN TYR 9.2e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8PO4A P00533 700 1014 1210.0 26X:1101 Type1.5_Back Inactive DFGin 6.414 12.877 BLBplus -129.71, 175.35 61.58, 31.97 -84.17, 147.82 49.64, 93.29 52.87, 31.63 out-out out 14.96 Saltbr-out 16.421 HRD-in -66.94, -58.73 81.99, -13.79 out-out-out SNCooo out-out ActLoopNT-out 6.901 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.59 APE8-dihe-in -76.52, 64.66 APE8-rot-na 30.38 APE67-dihe-in -71.47, -7.3 -48.65, -42.92 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.097 V948R None None XRAY 1.621 0.211 0.243 A 328 307 8 0 0 8 [[712, 970]] 1.0 8po4 Homo sapiens TYR_EGFR_HUMAN TYR 7.9e-88 300.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3LZBA P00533 703 983 1210.0 ITI:60001 Type1.5_Back Inactive DFGin 4.413 14.113 BLBplus -125.13, 176.44 56.08, 40.39 -84.19, 136.21 42.68, 101.81 78.32, 7.67 out-out out 14.281 Saltbr-out 16.067 HRD-in -64.02, -64.87 94.19, -31.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 170.85 APE9-dihe-in -92.26, 121.26 APE8-dihe-in -64.31, 51.85 APE8-rot-na 8.36 APE67-dihe-in -68.59, -1.05 -39.19, -47.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.357 APE9-dist-out 8.223 V948R None None XRAY 2.7 0.206 0.257 A 327 265 16 0 0 16 [[712, 970]] 1.0 3lzb Homo sapiens TYR_EGFR_HUMAN TYR 7.8e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3LZBB P00533 703 983 1210.0 ITI:60001 Type1.5_Back Inactive DFGin 4.381 13.959 BLBplus -119.7, -179.35 54.89, 41.32 -86.82, 133.57 41.54, 106.13 73.46, 9.05 out-out out 14.275 Saltbr-out 16.097 HRD-in -65.79, -60.12 87.79, -17.38 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 175.31 APE9-dihe-in -89.1, 120.24 APE8-dihe-in -68.59, 65.01 APE8-rot-na 30.46 APE67-dihe-in -68.36, -3.12 -48.63, -40.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.171 APE9-dist-in 7.817 V948R None None XRAY 2.7 0.206 0.257 B 327 265 16 0 0 16 [[712, 970]] 1.0 3lzb Homo sapiens TYR_EGFR_HUMAN TYR 7.8e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3LZBC P00533 704 983 1210.0 ITI:60001 Type1.5_Back Inactive DFGin 4.388 14.034 BLBplus -132.56, 174.78 57.2, 36.27 -81.82, 140.08 44.1, 102.6 73.85, 8.44 out-out out 13.853 Saltbr-out 16.045 HRD-in -67.43, -53.65 76.74, -16.56 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 172.19 APE9-dihe-in -92.55, 117.86 APE8-dihe-in -70.59, 65.45 APE8-rot-na 30.7 APE67-dihe-in -69.07, -2.07 -45.86, -43.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.409 APE9-dist-in 7.638 V948R None None XRAY 2.7 0.206 0.257 C 327 259 21 0 0 16 [[712, 970]] 1.0 3lzb Homo sapiens TYR_EGFR_HUMAN TYR 7.8e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3LZBD P00533 703 983 1210.0 ITI:60001 Type1.5_Back Inactive DFGin 4.542 14.207 BLBplus -128.51, 168.04 64.67, 28.61 -76.12, 143.44 45.13, 102.55 72.45, 3.46 out-out out 14.931 Saltbr-out 17.043 HRD-in -64.23, -56.15 80.94, -21.59 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -168.64 APE9-dihe-in -94.62, 117.93 APE8-dihe-in -68.62, 65.64 APE8-rot-na 31.36 APE67-dihe-in -68.52, -3.42 -48.32, -42.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.196 APE9-dist-in 7.812 V948R None None XRAY 2.7 0.206 0.257 D 327 261 20 0 0 16 [[712, 970]] 1.0 3lzb Homo sapiens TYR_EGFR_HUMAN TYR 7.8e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3POZA P00533 701 1017 1210.0 03P:1023 Type1.5_Back Inactive DFGin 4.451 13.643 BLBplus -134.04, 177.92 66.76, 22.09 -77.01, 146.77 49.04, 92.91 73.32, 4.89 out-out out 14.048 Saltbr-out 14.594 HRD-in -70.57, -55.32 77.16, -8.09 out-out-none SNCoon out-none ActLoopNT-out 6.294 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 142.54 APE9-dihe-in -117.89, 144.54 APE8-dihe-in -79.69, 70.35 APE8-rot-na 31.29 APE67-dihe-in -71.87, -5.08 -51.91, -42.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.87 APE9-dist-in 7.568 None None None XRAY 1.5 0.22 0.243 A 327 293 18 0 0 7 [[712, 970]] 1.0 3poz Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3W2SA P00533 701 1019 1210.0 W2R:1101 Type1.5_Back Inactive DFGin 4.791 13.496 BLBplus -137.24, -178.36 61.1, 30.66 -95.07, 163.05 54.49, 90.43 79.34, 159.34 out-out out 14.307 Saltbr-out 13.317 HRD-in -69.79, -50.96 77.18, -17.46 out-out-out SNCooo out-out ActLoopNT-out 7.351 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 138.15 APE9-dihe-in -81.88, 121.8 APE8-dihe-in -75.83, 61.34 APE8-rot-na 27.79 APE67-dihe-in -72.23, -7.73 -51.73, -42.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 15.728 APE9-dist-out 8.291 None None None XRAY 1.9 0.207 0.258 A 330 307 12 0 0 12 [[712, 970]] 1.0 3w2s Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3W32A P00533 701 1017 1210.0 W32:1101 Type1.5_Back Inactive DFGin 4.654 13.377 BLBplus -134.93, 174.75 75.62, 15.73 -74.59, 136.0 48.33, 88.42 85.13, 3.49 out-out out 14.094 Saltbr-out 13.598 HRD-in -69.8, -59.18 76.05, -4.36 out-out-in SNCooi out-in ActLoopNT-out 6.242 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.7, 158.18 APE9-dihe-in -131.47, 158.06 APE8-dihe-in -79.68, 77.14 APE8-rot-na 27.77 APE67-dihe-in -73.57, -6.08 -55.16, -38.17 APE12-dist-na 16.516 APE11-dist-na 12.808 APE10-dist-na 13.448 APE9-dist-in 7.197 None None None XRAY 1.8 0.202 0.236 A 330 317 0 0 0 0 [[712, 970]] 1.0 3w32 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3W33A P00533 701 1018 1210.0 W19:1101 Type1.5_Back Inactive DFGin 4.713 13.306 BLBplus -137.46, -177.59 63.41, 25.25 -82.13, 140.46 46.7, 89.54 72.41, 8.85 out-out out 14.305 Saltbr-out 15.578 HRD-in -70.28, -56.62 80.46, -14.05 out-out-none SNCoon out-none ActLoopNT-out 6.735 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 102.54 APE9-dihe-in -105.56, 138.68 APE8-dihe-in -74.54, 70.67 APE8-rot-na 26.75 APE67-dihe-in -78.38, -6.64 -55.74, -35.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.105 APE9-dist-in 7.859 None None None XRAY 1.7 0.199 0.233 A 330 297 17 0 0 12 [[712, 970]] 1.0 3w33 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 1XKKA P00533 702 1018 1210.0 FMM:91 Type1.5_Back Inactive DFGin 4.633 13.862 BLBplus -142.44, -178.32 66.71, 16.01 -82.53, 163.31 49.94, 92.67 85.22, -36.9 out-out out 13.318 Saltbr-out 13.504 HRD-in -57.62, -56.43 78.67, -6.78 out-out-out SNCooo out-out ActLoopNT-out 6.262 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 94.63 APE8-dihe-out -68.36, 44.76 APE8-rot-na 338.83 APE67-dihe-in -77.24, -6.92 -41.16, -39.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.332 None None None XRAY 2.4 0.209 0.255 A 352 289 16 0 0 8 [[712, 970]] 1.0 1xkk Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-87 299.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8PO1A P00533 699 984 1210.0 2EI:61101 Type1.5_Back Inactive DFGin 9.117 13.761 BLBplus -125.95, 174.55 63.29, 27.9 -79.94, 142.02 40.25, 91.32 70.27, 11.76 out-out out 15.823 Saltbr-out 16.526 HRD-in -64.69, -54.66 73.39, -11.95 out-out-none SNCoon out-none ActLoopNT-out 6.807 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 110.41 APE8-dihe-in -78.71, 67.67 APE8-rot-na 28.95 APE67-dihe-in -72.75, -5.56 -46.63, -44.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.854 V948R None None XRAY 2.11 0.253 0.275 A 332 274 12 0 0 12 [[712, 970]] 1.0 8po1 Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8PO2A P00533 705 984 1210.0 26X:61101 Type1.5_Back Inactive DFGin 8.434 13.424 BLBplus -127.32, 170.0 62.53, 23.96 -71.08, 137.71 39.46, 86.24 60.84, 7.23 out-out out 16.74 Saltbr-out 16.215 HRD-in -57.53, -58.75 81.17, -7.29 out-out-none SNCoon out-none ActLoopNT-out 6.851 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 109.54 APE8-dihe-in -73.86, 76.5 APE8-rot-na 29.52 APE67-dihe-in -70.72, -9.55 -57.41, -38.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.881 V948R None None XRAY 2.28 0.196 0.246 A 332 268 12 0 0 12 [[712, 970]] 1.0 8po2 Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8PO2B P00533 702 984 1210.0 26X:61101 Type1.5_Back Inactive DFGin 8.069 13.788 BLBplus -112.88, 172.51 68.29, 13.84 -71.64, 140.71 51.27, 88.14 70.36, 3.83 out-out out 16.4 Saltbr-out 16.068 HRD-in -71.57, -60.59 82.79, -10.73 out-out-none SNCoon out-none ActLoopNT-out 6.737 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.17 APE8-dihe-in -79.43, 73.37 APE8-rot-na 31.37 APE67-dihe-in -68.51, -4.77 -58.78, -46.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.845 V948R None None XRAY 2.28 0.196 0.246 B 332 271 12 0 0 12 [[712, 970]] 1.0 8po2 Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9EWSA P00533 703 984 1210.0 A1H7N:61101 Type1.5_Back Inactive DFGin 5.652 13.831 BLBplus -124.76, 171.69 64.56, 37.53 -90.55, 139.48 51.46, 89.18 73.73, -4.13 out-out out 15.397 Saltbr-out 13.594 HRD-in -50.82, -55.36 72.45, -9.66 out-out-none SNCoon out-none ActLoopNT-out 6.098 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 104.58 APE8-dihe-in -81.99, 76.73 APE8-rot-na 31.18 APE67-dihe-in -64.5, 7.66 -49.18, -51.24 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.539 V948R None None XRAY 2.435 0.23 0.326 A 332 270 12 0 0 12 [[712, 970]] 1.0 9ews Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9EWTA P00533 703 984 1210.0 A1H7O:61101 Type1.5_Back Inactive DFGin 7.52 13.282 BLBplus -126.22, 168.9 67.49, 27.27 -77.28, 137.19 37.5, 85.6 57.97, 18.29 out-out out 16.063 Saltbr-out 16.774 HRD-in -64.15, -44.83 71.6, -39.03 out-out-out SNCooo out-out ActLoopNT-out 6.132 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.93 APE8-dihe-in -66.6, 94.08 APE8-rot-na 23.81 APE67-dihe-in -68.36, -26.48 -72.94, -33.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.455 V948R None None XRAY 3.019 0.238 0.342 A 332 270 12 0 0 12 [[712, 970]] 1.0 9ewt Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9EWTB P00533 703 984 1210.0 A1H7O:61101 Type1.5_Back Inactive DFGin 7.48 12.417 BLBplus -127.27, 169.71 57.86, 28.37 -72.42, 129.96 42.21, 100.6 74.66, -18.63 out-out out 15.176 Saltbr-out 16.331 HRD-in -58.87, -43.22 64.98, -9.53 out-out-none SNCoon out-none ActLoopNT-out 6.209 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.78 APE8-dihe-in -75.53, 79.59 APE8-rot-na 28.36 APE67-dihe-in -57.45, -45.92 -56.17, -38.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.505 V948R None None XRAY 3.019 0.238 0.342 B 332 270 12 0 0 12 [[712, 970]] 1.0 9ewt Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9GC4A P00533 703 984 1210.0 A1IZ7:61101 Type1.5_Back Inactive DFGin 5.441 13.105 BLBplus -109.8, 172.26 66.58, 31.46 -76.63, 144.79 41.68, 86.31 67.13, 5.16 out-out out 14.238 Saltbr-out 16.474 HRD-in -70.19, -48.03 77.36, -13.98 out-out-out SNCooo out-out ActLoopNT-out 7.108 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -83.34, -21.98 APE9-dihe-in -66.5, 130.36 APE8-dihe-in -82.93, 68.65 APE8-rot-na 28.49 APE67-dihe-in -78.96, 0.06 -56.31, -35.6 APE12-dist-na 17.12 APE11-dist-na 17.207 APE10-dist-na 12.588 APE9-dist-out 8.271 V948R None None XRAY 2.415 0.218 0.248 A 332 282 0 0 0 0 [[712, 970]] 1.0 9gc4 Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9GC4B P00533 703 984 1210.0 A1IZ7:61101 Type1.5_Back Inactive DFGin 4.916 13.352 BLBplus -109.37, 174.94 66.51, 23.29 -75.86, 137.04 48.21, 94.45 85.45, -20.15 out-out out 14.478 Saltbr-out 14.461 HRD-in -67.81, -57.01 77.79, -1.27 out-out-out SNCooo out-out ActLoopNT-out 6.407 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -91.21, 3.02 APE9-dihe-in -94.27, 129.32 APE8-dihe-in -83.53, 68.53 APE8-rot-na 28.65 APE67-dihe-in -77.55, -0.63 -56.32, -35.82 APE12-dist-na 16.945 APE11-dist-na 16.877 APE10-dist-na 12.32 APE9-dist-out 8.141 V948R None None XRAY 2.415 0.218 0.248 B 332 282 0 0 0 0 [[712, 970]] 1.0 9gc4 Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9HBOA P00533 702 986 1210.0 A1IUK:61101 Type1.5_Back Inactive DFGin 5.205 13.501 BLBplus -119.94, 175.34 66.34, 20.96 -73.32, 136.12 49.79, 85.71 78.53, -8.02 out-none out 13.985 Saltbr-none 999.0 HRD-in -66.69, -51.95 79.88, -14.14 none-out-out SNCnoo out-out ActLoopNT-out 6.899 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 118.12 APE9-dihe-in -76.23, 133.71 APE8-dihe-in -83.6, 64.85 APE8-rot-na 29.55 APE67-dihe-in -72.82, -1.73 -50.01, -41.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.553 APE9-dist-out 8.321 V948R None None XRAY 2.45 0.228 0.255 A 332 274 11 0 0 11 [[712, 970]] 1.0 9hbo Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9HBOB P00533 702 985 1210.0 A1IUK:61101 Type1.5_Back Inactive DFGin 5.178 13.613 BLBplus -119.57, 175.0 66.78, 20.15 -72.91, 140.31 50.15, 87.63 76.53, -8.09 out-none out 13.868 Saltbr-none 999.0 HRD-in -66.74, -52.01 79.37, -12.83 none-out-out SNCnoo out-out ActLoopNT-out 6.665 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -114.41, 116.5 APE9-dihe-in -78.42, 132.58 APE8-dihe-in -84.37, 63.76 APE8-rot-na 29.82 APE67-dihe-in -72.45, -2.09 -49.92, -41.53 APE12-dist-na 999.0 APE11-dist-na 13.533 APE10-dist-na 14.554 APE9-dist-out 8.405 V948R None None XRAY 2.45 0.228 0.255 B 332 278 6 0 0 6 [[712, 970]] 1.0 9hbo Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-85 293.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6WAKC P00533 701 1014 1210.0 TQA:1301 Type1.5_Front Inactive DFGin 4.108 14.307 BLBplus -128.74, 170.35 57.84, 42.31 -80.67, 146.74 56.84, 84.42 73.11, 52.84 out-out out 13.687 Saltbr-out 13.168 HRD-in -69.35, -57.7 81.97, -4.79 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -99.43 APE9-dihe-in -140.88, 118.68 APE8-dihe-in -72.34, 69.57 APE8-rot-na 41.21 APE67-dihe-in -76.32, 0.41 -56.53, -41.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.489 APE9-dist-out 8.042 T790M,V948R None None XRAY 2.4 0.219 0.23 C 328 299 15 0 0 15 [[712, 970]] 1.0 6wak Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6WXNC P00533 701 1014 1210.0 UEJ:1301 Type1.5_Front Inactive DFGin 5.149 14.242 BLBplus -125.79, 168.58 69.11, 30.42 -73.13, 126.76 42.33, 95.66 91.61, -9.41 out-out out 13.559 Saltbr-out 12.827 HRD-in -75.25, -56.93 84.93, -23.09 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.4 APE8-dihe-in -83.07, 65.64 APE8-rot-na 32.78 APE67-dihe-in -77.0, -5.94 -52.82, -37.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.347 T790M,V948R None None XRAY 1.76 0.209 0.235 C 328 286 28 0 0 16 [[712, 970]] 1.0 6wxn Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6WXND P00533 702 1014 1210.0 UEJ:1101 Type1.5_Front Inactive DFGin 5.021 14.15 BLBplus -127.07, 163.26 73.25, 22.29 -63.33, 141.68 45.73, 93.45 80.75, -14.01 out-out out 13.653 Saltbr-out 13.598 HRD-in -75.42, -56.41 82.09, -17.01 out-out-none SNCoon out-none ActLoopNT-out 6.661 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.16 APE8-dihe-in -83.51, 70.14 APE8-rot-na 34.07 APE67-dihe-in -73.61, -7.52 -55.72, -38.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.723 T790M,V948R None None XRAY 1.76 0.209 0.235 D 328 292 16 0 0 13 [[712, 970]] 1.0 6wxn Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8TO3A P00533 702 1007 1210.0 IXC:1101 Type1.5_Front Inactive DFGin 4.371 13.996 BLBplus -135.94, 169.11 67.48, 22.01 -70.94, 138.5 62.13, 97.63 90.56, 75.28 out-out out 13.482 Saltbr-out 16.432 HRD-in -64.1, -62.98 87.72, -19.67 out-out-out SNCooo out-out ActLoopNT-out 8.667 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.18 APE8-dihe-in -84.44, 67.85 APE8-rot-na 34.08 APE67-dihe-in -75.79, -1.46 -59.58, -38.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.492 T790M,V948R None None XRAY 2.49 0.231 0.269 A 328 291 15 0 0 15 [[712, 970]] 1.0 8to3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7LG8B P00533 702 1002 1210.0 VNS:1101,8RC:1102 Type1.5_Front,Type1 Inactive DFGin 4.918 14.797 BLBplus -141.19, 170.16 49.38, 57.43 -105.85, 156.28 47.74, 86.43 72.05, 29.16 out-out out 13.829 Saltbr-out 11.399 HRD-in -68.62, -56.52 80.22, -7.8 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 72.88 APE9-dihe-in -61.52, 127.34 APE8-dihe-in -70.71, 68.41 APE8-rot-na 28.03 APE67-dihe-in -75.05, -4.72 -60.67, -37.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.938 APE9-dist-out 8.676 T790M,V948R None None XRAY 2.93 0.237 0.27 B 331 275 15 0 0 15 [[712, 970]] 1.0 7lg8 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5ZWJA P00533 702 985 1210.0 9LL:1101 Type3 Inactive DFGin 5.542 14.462 BLBplus -134.76, 169.78 70.33, 21.35 -80.26, 157.71 46.02, 86.11 85.63, 6.58 out-none out 12.365 Saltbr-none 999.0 HRD-in -62.57, -46.38 74.18, -0.41 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 170.69 APE8-dihe-in -84.81, 75.57 APE8-rot-na 34.77 APE67-dihe-in -62.54, -42.94 -62.02, -41.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.058 T790M,C797S,V948R None None XRAY 2.9 0.256 0.272 A 355 267 17 0 0 17 [[712, 970]] 1.0 5zwj Homo sapiens TYR_EGFR_HUMAN TYR 5.9e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8A2BA P00533 702 990 1210.0 KY9:1101 Type3 Inactive DFGin 5.426 14.435 BLBplus -143.53, -174.33 44.34, 37.79 -92.75, 167.36 44.38, 91.12 110.41, -145.91 out-out out 13.246 Saltbr-out 12.26 HRD-in -75.49, -60.69 77.7, -7.21 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.84 APE8-dihe-in -84.13, 67.89 APE8-rot-na 33.21 APE67-dihe-in -76.37, -2.66 -52.66, -40.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.066 L858R,V948R None None XRAY 1.69 0.212 0.258 A 326 272 17 0 0 17 [[712, 970]] 1.0 8a2b Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6P1DC P00533 702 1006 1210.0 NQ1:1101,ANP:1102 Type3,ATPlike Inactive DFGin 5.383 14.459 BLBplus -142.0, 171.97 66.8, 29.01 -86.08, 152.7 44.82, 92.23 73.36, -11.9 out-out out 13.614 Saltbr-out 13.736 HRD-in -69.23, -60.69 76.65, -2.9 out-out-none SNCoon out-none ActLoopNT-out 6.785 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.45 APE8-dihe-in -76.51, 79.09 APE8-rot-na 31.04 APE67-dihe-in -75.49, -1.74 -58.74, -40.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.258 None None None XRAY 2.4 0.195 0.213 C 327 292 13 0 0 13 [[712, 970]] 1.0 6p1d Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6P1DD P00533 701 1008 1210.0 NQ1:1101,ANP:1102 Type3,ATPlike Inactive DFGin 4.796 14.102 BLBplus -132.01, 171.13 65.01, 17.93 -68.87, 143.86 51.94, 90.04 79.55, -15.22 out-out out 13.622 Saltbr-out 13.734 HRD-in -75.21, -58.43 80.83, -11.58 out-out-none SNCoon out-none ActLoopNT-out 6.633 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.5 APE8-dihe-in -78.23, 70.43 APE8-rot-na 33.16 APE67-dihe-in -74.16, -5.23 -50.48, -45.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.251 None None None XRAY 2.4 0.195 0.213 D 327 295 13 0 0 13 [[712, 970]] 1.0 6p1d Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXQA P00533 700 1007 1210.0 VNS:1102,ANP:1103 Type3,ATPlike Inactive DFGin 4.86 14.542 BLBplus -136.59, 171.99 58.78, 36.07 -93.08, 163.3 53.5, 85.99 81.0, 16.2 out-out out 13.6 Saltbr-out 11.402 HRD-in -66.89, -59.97 80.26, -12.87 out-out-out SNCooo out-out ActLoopNT-out 8.834 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 0.37 APE9-dihe-in -62.95, 136.95 APE8-dihe-in -80.94, 64.03 APE8-rot-na 32.82 APE67-dihe-in -75.31, -4.79 -52.17, -43.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.411 APE9-dist-out 8.21 T790M,V948R None None XRAY 1.83 0.185 0.218 A 331 296 12 0 0 12 [[712, 970]] 1.0 7jxq Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXQC P00533 700 1007 1210.0 VNS:1102,ANP:1103 Type3,ATPlike Inactive DFGin 4.785 14.453 BLBplus -135.56, 173.47 59.34, 36.33 -94.04, 161.61 52.57, 85.94 80.36, 16.26 out-out out 13.527 Saltbr-out 12.033 HRD-in -65.88, -57.49 78.82, -12.32 out-out-none SNCoon out-none ActLoopNT-out 8.819 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.15 APE8-dihe-in -80.46, 67.52 APE8-rot-na 31.26 APE67-dihe-in -73.66, -6.11 -51.25, -43.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.434 T790M,V948R None None XRAY 1.83 0.185 0.218 C 331 298 10 0 0 10 [[712, 970]] 1.0 7jxq Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6XL4B P00533 700 1007 1210.0 NQ1:1201,Q6K:1202 Type3,Type1 Inactive DFGin 4.808 14.497 BLBplus -133.43, 176.08 66.75, 17.79 -78.7, 146.83 53.41, 93.69 78.85, 14.72 out-out out 13.809 Saltbr-out 14.224 HRD-in -71.6, -57.82 77.95, -5.56 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.66 APE8-dihe-in -77.94, 72.67 APE8-rot-na 31.42 APE67-dihe-in -72.46, -3.15 -55.35, -40.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.932 T790M,V948R None None XRAY 2.06 0.216 0.252 B 328 292 16 0 0 16 [[712, 970]] 1.0 6xl4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXPC P00533 700 1007 1210.0 JBJ:1101,YY3:1102 Type3,Type1 Inactive DFGin 4.791 14.489 BLBplus -135.14, 166.93 58.75, 39.54 -88.72, 165.62 50.16, 82.07 80.91, 11.4 out-out out 13.215 Saltbr-out 10.01 HRD-in -71.03, -65.61 90.59, -16.24 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.4 APE8-dihe-in -78.08, 71.31 APE8-rot-na 31.49 APE67-dihe-in -74.31, -4.1 -55.2, -45.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.734 T790M,V948R None None XRAY 2.16 0.214 0.247 C 331 292 16 0 0 16 [[712, 970]] 1.0 7jxp Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXPE P00533 700 1007 1210.0 JBJ:1101,YY3:1102 Type3,Type1 Inactive DFGin 5.017 14.71 BLBplus -135.91, 163.38 57.21, 38.2 -87.34, 167.11 54.31, 95.16 79.16, 16.43 out-out out 13.581 Saltbr-out 11.008 HRD-in -68.91, -62.25 86.58, -12.8 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.81 APE8-dihe-in -81.71, 69.65 APE8-rot-na 31.8 APE67-dihe-in -77.02, -5.14 -52.47, -41.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.46 T790M,V948R None None XRAY 2.16 0.214 0.247 E 331 287 16 0 0 16 [[712, 970]] 1.0 7jxp Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7LG8A P00533 702 1006 1210.0 VNS:1101,8RC:1102 Type3,Type1 Inactive DFGin 4.633 14.844 BLBplus -140.27, 173.45 52.29, 60.01 -103.04, 154.16 45.73, 86.09 71.19, 28.15 out-out out 14.014 Saltbr-out 11.713 HRD-in -68.53, -55.23 80.07, -8.53 out-out-out SNCooo out-out ActLoopNT-out 9.249 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.7 APE8-dihe-in -73.13, 67.89 APE8-rot-na 28.49 APE67-dihe-in -77.47, -4.15 -60.09, -40.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.274 T790M,V948R None None XRAY 2.93 0.237 0.27 A 331 280 15 0 0 15 [[712, 970]] 1.0 7lg8 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7LG8C P00533 703 1004 1210.0 VNS:1101,8RC:1102 Type3,Type1 Inactive DFGin 4.832 14.737 BLBplus -140.02, 171.29 50.44, 57.58 -106.29, 155.85 48.29, 87.01 71.42, 29.21 out-out out 13.235 Saltbr-out 10.883 HRD-in -68.15, -55.55 79.56, -8.95 out-out-out SNCooo out-out ActLoopNT-out 9.216 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.11 APE8-dihe-in -71.99, 68.12 APE8-rot-na 28.1 APE67-dihe-in -76.72, -3.4 -59.75, -39.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.305 T790M,V948R None None XRAY 2.93 0.237 0.27 C 331 274 15 0 0 15 [[712, 970]] 1.0 7lg8 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7LG8D P00533 702 1003 1210.0 VNS:1101,8RC:1102 Type3,Type1 Inactive DFGin 4.926 15.183 BLBplus -140.41, 172.1 51.47, 58.23 -106.49, 156.3 49.03, 86.93 72.22, 33.01 out-out out 13.784 Saltbr-out 11.231 HRD-in -67.28, -53.4 81.73, -11.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.55 APE8-dihe-in -71.42, 69.12 APE8-rot-na 28.09 APE67-dihe-in -78.92, -4.05 -59.63, -41.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.446 T790M,V948R None None XRAY 2.93 0.237 0.27 D 331 271 17 0 0 17 [[712, 970]] 1.0 7lg8 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7A2AA P00533 700 984 1210.0 57N:1101,7G9:1102 Type3,Type1 Inactive DFGin 4.79 14.981 BLBplus -131.59, 170.62 61.54, 34.7 -80.75, 149.06 48.24, 92.48 77.59, 7.85 out-out out 13.521 Saltbr-out 11.363 HRD-in -68.93, -60.4 81.46, -8.87 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.16 APE8-dihe-in -83.82, 69.63 APE8-rot-na 32.14 APE67-dihe-in -69.62, -9.49 -57.3, -43.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.02 T790M,V948R None None XRAY 1.9 0.195 0.217 A 333 266 19 0 0 17 [[712, 970]] 1.0 7a2a Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7A2AB P00533 699 984 1210.0 57N:1101,7G9:1102 Type3,Type1 Inactive DFGin 5.429 14.754 BLBplus -131.31, 171.38 59.7, 35.33 -84.58, 153.3 50.04, 92.4 77.68, 999.0 out-out out 13.16 Saltbr-out 10.438 HRD-in -66.1, -59.16 82.47, -6.26 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.47 APE8-dihe-in -82.95, 68.33 APE8-rot-na 32.13 APE67-dihe-in -69.29, -8.38 -57.66, -41.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.16 T790M,V948R None None XRAY 1.9 0.195 0.217 B 333 268 18 0 0 18 [[712, 970]] 1.0 7a2a Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7K1HA P00533 701 1007 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 4.897 14.502 BLBplus -130.97, 170.62 58.17, 48.68 -100.05, 161.6 49.16, 78.42 69.2, 1.23 out-out out 13.749 Saltbr-out 11.264 HRD-in -77.07, -52.87 73.56, -9.67 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.57 APE8-dihe-in -79.59, 69.97 APE8-rot-na 32.69 APE67-dihe-in -73.02, -4.47 -58.4, -43.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.87 L858R,V948R None None XRAY 2.602 0.233 0.275 A 331 291 16 0 0 16 [[712, 970]] 1.0 7k1h Homo sapiens TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7K1HB P00533 701 1008 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 5.245 14.539 BLBplus -131.19, 172.0 58.43, 45.25 -101.59, 170.23 51.81, 92.29 77.64, 116.53 out-out out 13.419 Saltbr-out 9.137 HRD-in -79.53, -53.07 76.7, -9.03 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.65 APE8-dihe-in -81.29, 70.54 APE8-rot-na 31.4 APE67-dihe-in -72.0, -4.51 -57.97, -43.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.952 L858R,V948R None None XRAY 2.602 0.233 0.275 B 331 291 17 0 0 17 [[712, 970]] 1.0 7k1h Homo sapiens TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7K1HC P00533 701 1007 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 4.744 14.74 BLBplus -129.93, 170.49 56.69, 44.1 -96.18, 166.59 55.18, 77.55 73.78, 46.77 out-out out 13.454 Saltbr-out 8.834 HRD-in -79.27, -50.75 74.55, -8.77 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.24 APE8-dihe-in -82.15, 68.56 APE8-rot-na 31.93 APE67-dihe-in -74.95, -6.33 -58.99, -43.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.006 L858R,V948R None None XRAY 2.602 0.233 0.275 C 331 290 17 0 0 17 [[712, 970]] 1.0 7k1h Homo sapiens TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7K1HD P00533 701 1007 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 5.019 14.819 BLBplus -131.91, 172.88 57.19, 43.91 -99.27, 163.9 51.77, 84.58 74.04, -2.08 out-out out 13.649 Saltbr-out 10.156 HRD-in -78.62, -53.76 74.56, -9.86 out-out-out SNCooo out-out ActLoopNT-out 9.68 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.98 APE8-dihe-in -78.93, 62.04 APE8-rot-na 29.95 APE67-dihe-in -73.79, -3.52 -56.56, -42.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.07 L858R,V948R None None XRAY 2.602 0.233 0.275 D 331 292 15 0 0 15 [[712, 970]] 1.0 7k1h Homo sapiens TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7K1HE P00533 703 1007 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 5.157 14.635 BLBplus -131.84, 173.0 58.55, 47.55 -102.27, 167.87 51.85, 86.34 79.14, -85.43 out-out out 13.629 Saltbr-out 10.317 HRD-in -78.55, -50.1 74.47, -8.94 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.83 APE8-dihe-in -83.11, 68.71 APE8-rot-na 30.98 APE67-dihe-in -72.18, -4.84 -60.68, -43.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.99 L858R,V948R None None XRAY 2.602 0.233 0.275 E 331 289 16 0 0 16 [[712, 970]] 1.0 7k1h Homo sapiens TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7K1HF P00533 701 1007 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 4.905 14.421 BLBplus -132.01, 174.64 57.0, 46.09 -100.49, 170.69 50.88, 85.85 82.59, -107.03 out-out out 13.717 Saltbr-out 10.964 HRD-in -78.66, -52.82 76.59, -9.2 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.26 APE8-dihe-in -81.53, 68.79 APE8-rot-na 32.04 APE67-dihe-in -72.57, -5.45 -59.56, -43.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.067 L858R,V948R None None XRAY 2.602 0.233 0.275 F 331 290 17 0 0 17 [[712, 970]] 1.0 7k1h Homo sapiens TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6P1DA P00533 700 1021 1210.0 ANP:1101 ATPlike Inactive DFGin 5.301 16.437 BLBtrans -129.26, 172.58 65.52, 23.29 -64.33, 142.93 151.16, 79.23 78.73, -15.31 out-out out 13.52 Saltbr-out 12.421 HRD-in -76.98, -57.73 83.77, -12.82 out-out-none SNCoon out-none ActLoopNT-out 7.141 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 149.92 APE9-dihe-in -115.71, 137.77 APE8-dihe-in -79.58, 71.21 APE8-rot-na 32.94 APE67-dihe-in -73.74, -5.13 -51.22, -45.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.184 APE9-dist-in 7.677 None None None XRAY 2.4 0.195 0.213 A 327 309 13 0 0 13 [[712, 970]] 1.0 6p1d Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6WAKB P00533 701 1020 1210.0 ANP:1101 ATPlike Inactive DFGin 5.177 16.231 BLBtrans -117.23, 173.55 69.28, 15.65 -59.01, 135.6 148.98, 94.52 90.59, -20.79 out-out out 13.949 Saltbr-out 13.543 HRD-in -74.15, -58.44 85.37, -10.97 out-out-none SNCoon out-none ActLoopNT-out 6.481 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -3.86 APE9-dihe-in -108.7, 124.16 APE8-dihe-in -81.26, 64.66 APE8-rot-na 31.83 APE67-dihe-in -71.85, -2.7 -48.1, -51.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.366 APE9-dist-in 7.826 T790M,V948R None None XRAY 2.4 0.219 0.23 B 328 316 4 0 0 4 [[712, 970]] 1.0 6wak Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6WXNB P00533 701 1021 1210.0 ANP:1101 ATPlike Inactive DFGin 5.283 16.295 BLBtrans -123.51, 174.07 66.96, 19.19 -61.23, 137.15 158.07, 75.44 91.96, -18.66 out-out out 13.565 Saltbr-out 13.523 HRD-in -75.09, -55.39 80.46, -8.33 out-out-none SNCoon out-none ActLoopNT-out 6.48 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -21.86 APE9-dihe-in -115.99, 110.82 APE8-dihe-in -78.55, 77.75 APE8-rot-na 31.2 APE67-dihe-in -73.85, -5.28 -56.42, -42.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.825 APE9-dist-in 7.844 T790M,V948R None None XRAY 1.76 0.209 0.235 B 328 303 11 0 0 11 [[712, 970]] 1.0 6wxn Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8FV3B P00533 701 1021 1210.0 ANP:1102 ATPlike Inactive DFGin 5.439 16.496 BLBtrans -118.64, 177.37 63.4, 20.55 -58.75, 145.81 159.38, 77.34 77.7, -11.94 out-out out 13.907 Saltbr-out 12.609 HRD-in -79.27, -57.12 85.07, -16.18 out-out-none SNCoon out-none ActLoopNT-out 6.551 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -85.47 APE9-dihe-in -94.5, 111.51 APE8-dihe-in -78.45, 79.51 APE8-rot-na 26.67 APE67-dihe-in -72.96, -7.53 -57.83, -45.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.158 APE9-dist-in 7.609 T790M,V948R None None XRAY 2.1 0.191 0.226 B 328 307 12 0 0 12 [[712, 970]] 1.0 8fv3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8FV3D P00533 701 1008 1210.0 ANP:1102 ATPlike Inactive DFGin 5.123 16.069 BLBtrans -118.91, 178.66 63.22, 20.1 -58.76, 136.59 151.59, 72.8 86.53, -14.56 out-out out 13.636 Saltbr-out 11.878 HRD-in -77.73, -54.76 83.51, -15.49 out-out-none SNCoon out-none ActLoopNT-out 6.686 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -35.35 APE9-dihe-in -75.26, 139.37 APE8-dihe-in -77.41, 75.08 APE8-rot-na 30.35 APE67-dihe-in -77.52, -1.37 -56.44, -41.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.989 APE9-dist-in 7.856 T790M,V948R None None XRAY 2.1 0.191 0.226 D 328 295 13 0 0 12 [[712, 970]] 1.0 8fv3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8FV4A P00533 701 1013 1210.0 ANP:1102 ATPlike Inactive DFGin 5.115 16.083 BLBtrans -131.04, 178.71 63.39, 21.89 -65.77, 133.12 153.56, 67.25 81.77, -5.74 out-out out 13.965 Saltbr-out 14.366 HRD-in -75.29, -65.35 93.54, -10.41 out-out-out SNCooo out-out ActLoopNT-out 6.614 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.22 APE8-dihe-in -79.99, 70.44 APE8-rot-na 34.65 APE67-dihe-in -69.8, 5.09 -60.12, -39.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.027 T790M,V948R None None XRAY 2.2 0.204 0.261 A 328 298 15 0 0 13 [[712, 970]] 1.0 8fv4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8TO3C P00533 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 5.753 16.533 BLBtrans -133.38, -174.65 59.98, 24.74 -65.74, 136.64 157.32, 80.88 79.44, -13.7 out-out out 13.655 Saltbr-out 13.531 HRD-in -66.43, -56.05 80.37, -11.56 out-out-out SNCooo out-out ActLoopNT-out 6.373 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.97 APE8-dihe-in -84.11, 59.51 APE8-rot-na 29.31 APE67-dihe-in -74.18, -0.3 -51.78, -42.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.174 T790M,V948R None None XRAY 2.49 0.231 0.269 C 328 295 16 0 0 13 [[712, 970]] 1.0 8to3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8TO3D P00533 702 1008 1210.0 ANP:1102 ATPlike Inactive DFGin 6.266 16.712 BLBtrans -127.69, 172.31 68.6, 30.15 -69.25, 140.14 165.75, 69.84 67.25, -4.22 out-out out 14.386 Saltbr-out 13.199 HRD-in -68.61, -53.44 82.24, -15.94 out-out-out SNCooo out-out ActLoopNT-out 6.552 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.24 APE8-dihe-in -79.84, 75.73 APE8-rot-na 31.27 APE67-dihe-in -78.58, -0.75 -60.94, -39.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.144 T790M,V948R None None XRAY 2.49 0.231 0.269 D 328 293 14 0 0 13 [[712, 970]] 1.0 8to3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8TO4A P00533 701 1021 1210.0 ANP:1102 ATPlike Inactive DFGin 5.629 16.547 BLBtrans -124.14, -173.94 46.92, 31.67 -57.81, 155.21 158.64, 67.25 48.87, 11.58 out-out out 13.96 Saltbr-out 13.561 HRD-in -72.61, -58.43 93.96, -37.09 out-out-none SNCoon out-none ActLoopNT-out 6.932 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 82.65 APE8-dihe-in -66.65, 104.87 APE8-rot-na 26.84 APE67-dihe-in -69.56, -10.93 -75.01, -49.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.724 T790M,V948R None None XRAY 2.99 0.176 0.231 A 328 300 16 0 0 13 [[712, 970]] 1.0 8to4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4ZSEA P00533 699 1007 1210.0 ANP:1101 ATPlike Inactive DFGin 5.335 16.18 BLBtrans -132.89, 171.35 59.18, 30.95 -64.3, 136.47 153.66, 69.99 84.54, -7.18 out-out out 13.41 Saltbr-out 12.542 HRD-in -69.44, -53.13 80.36, -12.32 out-out-none SNCoon out-none ActLoopNT-out 6.5 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 151.84 APE9-dihe-in -73.75, 154.61 APE8-dihe-in -84.04, 78.01 APE8-rot-na 31.44 APE67-dihe-in -73.82, -9.83 -53.67, -42.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.754 APE9-dist-in 7.631 T790M,V948R None None XRAY 1.97 0.191 0.213 A 331 297 12 0 0 12 [[712, 970]] 1.0 4zse Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4ZSEB P00533 698 1022 1210.0 ANP:2001 ATPlike Inactive DFGin 5.443 16.534 BLBtrans -132.18, 168.84 69.74, 21.23 -63.33, 134.02 158.02, 77.95 88.87, -12.59 out-out out 13.594 Saltbr-out 12.729 HRD-in -70.54, -56.98 84.69, -9.62 out-out-none SNCoon out-none ActLoopNT-out 6.279 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -169.23 APE9-dihe-in -113.21, 138.46 APE8-dihe-in -83.6, 77.16 APE8-rot-na 29.29 APE67-dihe-in -64.08, -26.4 -59.09, -39.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.095 APE9-dist-in 7.664 T790M,V948R None None XRAY 1.97 0.191 0.213 B 331 313 12 0 0 12 [[712, 970]] 1.0 4zse Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4ZSEC P00533 700 1013 1210.0 ANP:3001 ATPlike Inactive DFGin 5.527 16.551 BLBtrans -132.06, 169.7 72.1, 15.79 -57.63, 131.91 161.52, 79.23 90.56, -14.81 out-out out 13.464 Saltbr-out 12.84 HRD-in -70.03, -52.52 81.38, -14.98 out-out-none SNCoon out-none ActLoopNT-out 6.218 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.83 APE8-dihe-in -83.98, 70.07 APE8-rot-na 31.43 APE67-dihe-in -69.54, -11.42 -60.89, -38.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.916 T790M,V948R None None XRAY 1.97 0.191 0.213 C 331 301 13 0 0 13 [[712, 970]] 1.0 4zse Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXMA P00533 700 1007 1210.0 ANP:1101 ATPlike Inactive DFGin 4.958 16.172 BLBtrans -132.35, 172.29 62.1, 35.15 -75.21, 146.26 142.71, 77.54 74.06, -11.26 out-out out 13.894 Saltbr-out 13.34 HRD-in -71.64, -59.02 81.62, -5.92 out-out-none SNCoon out-none ActLoopNT-out 8.072 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.88 APE8-dihe-in -79.6, 70.11 APE8-rot-na 34.33 APE67-dihe-in -76.06, -4.61 -47.57, -45.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.53 T790M,V948R None None XRAY 2.192 0.228 0.271 A 331 287 18 0 0 14 [[712, 970]] 1.0 7jxm Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8PO4B P00533 700 1014 1210.0 ATP:1101 ATPlike Inactive DFGin 5.624 16.394 BLBtrans -121.3, 175.63 63.19, 26.9 -63.92, 138.21 163.94, 68.04 83.38, -10.03 out-out out 13.6 Saltbr-out 13.029 HRD-in -73.28, -55.5 80.32, -14.85 out-out-out SNCooo out-out ActLoopNT-out 6.486 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.23 APE8-dihe-in -81.98, 63.66 APE8-rot-na 32.98 APE67-dihe-in -71.84, -8.05 -50.66, -40.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.255 V948R None None XRAY 1.621 0.211 0.243 B 328 295 20 0 0 13 [[712, 970]] 1.0 8po4 Homo sapiens TYR_EGFR_HUMAN TYR 7.9e-88 300.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2GS7A P00533 703 1012 1210.0 ANP:60301 ATPlike Inactive DFGin 5.373 16.634 BLBtrans -99.51, 171.1 60.81, 33.31 -69.51, 142.46 163.35, 73.66 92.75, -41.51 out-out out 14.089 Saltbr-out 13.075 HRD-in -69.91, -45.27 73.69, -18.97 out-out-out SNCooo out-out ActLoopNT-out 6.362 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 134.47 APE9-dihe-in -142.48, 136.32 APE8-dihe-in -67.69, 63.71 APE8-rot-na 37.05 APE67-dihe-in -69.28, 11.68 -49.57, -49.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.012 APE9-dist-out 8.2 V948R None None XRAY 2.6 0.258 0.298 A 330 281 4 0 0 4 [[712, 970]] 1.0 2gs7 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2GS7B P00533 701 1016 1210.0 ANP:60302 ATPlike Inactive DFGin 5.284 16.349 BLBtrans -104.25, 165.26 71.85, 26.96 -61.96, 139.7 163.92, 72.26 85.01, -32.88 out-out out 13.995 Saltbr-out 14.309 HRD-in -67.25, -42.1 68.95, -3.07 out-out-none SNCoon out-none ActLoopNT-out 6.473 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 151.84 APE9-dihe-in -148.05, 134.8 APE8-dihe-in -62.95, 72.83 APE8-rot-na 33.79 APE67-dihe-in -67.93, 1.22 -55.72, -45.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.13 APE9-dist-in 7.902 V948R None None XRAY 2.6 0.258 0.298 B 330 288 3 0 0 3 [[712, 970]] 1.0 2gs7 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3GT8A P00533 700 1014 1210.0 ANP:60002 ATPlike Inactive DFGin 4.993 16.39 BLBtrans -126.87, 160.91 79.29, 15.25 -62.33, 143.15 149.45, 88.24 77.42, 3.92 out-out out 14.088 Saltbr-out 14.957 HRD-in -72.04, -61.33 88.51, -0.69 out-out-none SNCoon out-none ActLoopNT-out 6.56 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 19.46 APE8-rot-na 342.23 APE67-dihe-in -68.79, -19.52 -40.63, -50.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V948R None None XRAY 2.955 0.219 0.275 A 330 300 15 0 0 15 [[712, 970]] 1.0 3gt8 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3GT8B P00533 701 1007 1210.0 ANP:60001 ATPlike Inactive DFGin 5.247 16.102 BLBtrans -113.7, -174.86 52.25, 31.77 -67.43, 143.58 157.41, 75.54 60.22, 2.12 out-out out 13.355 Saltbr-out 13.716 HRD-in -65.21, -59.58 85.13, -27.25 out-out-none SNCoon out-none ActLoopNT-out 6.384 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 3.18 APE8-rot-na 352.22 APE67-dihe-in -64.44, -9.93 -42.76, -50.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V948R None None XRAY 2.955 0.219 0.275 B 330 292 15 0 0 15 [[712, 970]] 1.0 3gt8 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3GT8C P00533 699 1007 1210.0 ANP:60003 ATPlike Inactive DFGin 4.731 16.042 BLBtrans -111.03, -172.93 50.46, 27.13 -68.53, 136.25 146.08, 72.89 59.13, 17.74 out-out out 14.315 Saltbr-out 13.283 HRD-in -57.94, -53.03 83.1, -30.64 out-out-none SNCoon out-none ActLoopNT-out 6.516 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.04 APE8-dihe-in -73.71, 55.48 APE8-rot-na 345.44 APE67-dihe-in -72.77, 4.68 -41.49, -48.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.982 V948R None None XRAY 2.955 0.219 0.275 C 330 296 13 0 0 13 [[712, 970]] 1.0 3gt8 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3GT8D P00533 701 1010 1210.0 ANP:60004 ATPlike Inactive DFGin 5.236 16.347 BLBtrans -129.98, 167.43 62.52, 32.14 -70.14, 140.82 152.86, 71.47 77.5, -20.57 out-out out 14.059 Saltbr-out 13.514 HRD-in -61.66, -53.51 87.8, -16.84 out-out-none SNCoon out-none ActLoopNT-out 6.797 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 30.46 APE8-rot-na 344.36 APE67-dihe-in -63.75, 2.23 -59.31, -42.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V948R None None XRAY 2.955 0.219 0.275 D 330 295 15 0 0 15 [[712, 970]] 1.0 3gt8 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5CNOA P00533 700 1015 1210.0 ANP:61001 ATPlike Inactive DFGin 5.504 16.161 BLBtrans -118.04, 171.2 68.22, 21.52 -56.79, 132.54 171.14, 68.18 99.53, -19.86 out-out out 13.718 Saltbr-out 12.944 HRD-in -82.44, -48.26 77.49, -9.43 out-out-out SNCooo out-out ActLoopNT-out 6.341 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 122.24 APE9-dihe-in -77.97, 140.5 APE8-dihe-in -80.47, 64.47 APE8-rot-na 27.48 APE67-dihe-in -78.06, -5.87 -50.51, -36.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.588 APE9-dist-out 8.271 V948R None None XRAY 1.55 0.176 0.203 A 330 300 16 0 0 11 [[712, 970]] 1.0 5cno Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5CNNB P00533 700 1014 1210.0 ANP:61101 ATPlike Inactive DFGin 5.571 16.39 BLBtrans -117.7, 174.34 67.16, 24.17 -60.91, 135.45 168.23, 72.49 97.23, -21.68 out-out out 13.788 Saltbr-out 12.759 HRD-in -80.25, -51.08 77.81, -11.48 out-out-out SNCooo out-out ActLoopNT-out 6.374 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -75.45 APE9-dihe-in -63.67, 125.67 APE8-dihe-in -78.86, 65.92 APE8-rot-na 30.44 APE67-dihe-in -73.57, -5.24 -51.98, -40.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.086 APE9-dist-out 8.279 I706Q None None XRAY 1.9 0.183 0.211 B 350 304 11 0 0 11 [[712, 970]] 1.0 5cnn Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6XL4C P00533 700 1011 1210.0 No_ligand No_ligand Inactive DFGin 5.173 16.517 BLBtrans -130.53, 179.54 70.03, 18.19 -70.23, 136.56 157.75, 76.14 77.79, 0.31 out-out out 14.194 Saltbr-out 13.111 HRD-in -72.76, -55.65 79.71, -6.02 out-out-none SNCoon out-none ActLoopNT-out 8.397 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -34.91 APE9-dihe-in -105.63, 136.03 APE8-dihe-in -73.26, 62.83 APE8-rot-na 34.69 APE67-dihe-in -76.36, -0.13 -55.59, -42.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.725 APE9-dist-in 7.853 T790M,V948R None None XRAY 2.06 0.216 0.252 C 328 302 10 0 0 7 [[712, 970]] 1.0 6xl4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7UKWD P00533 702 1012 1210.0 No_ligand No_ligand Inactive DFGin 5.111 16.402 BLBtrans -118.29, 176.11 63.98, 19.5 -58.45, 142.23 151.96, 85.11 74.09, -5.14 out-out out 14.506 Saltbr-out 14.168 HRD-in -78.92, -49.36 80.69, -15.83 out-out-none SNCoon out-none ActLoopNT-out 6.874 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -7.72 APE9-dihe-in -116.7, 121.41 APE8-dihe-in -78.74, 61.73 APE8-rot-na 35.22 APE67-dihe-in -71.17, 12.82 -43.8, -49.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.193 APE9-dist-in 7.4 T790M,V948R None None XRAY 2.6 0.198 0.25 D 328 300 6 0 0 6 [[712, 970]] 1.0 7ukw Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8FV4B P00533 702 1007 1210.0 No_ligand No_ligand Inactive DFGin 5.127 16.362 BLBtrans -126.57, 176.61 61.99, 14.29 -48.04, 140.93 155.83, 88.84 81.69, -24.77 out-out out 14.377 Saltbr-out 14.483 HRD-in -71.39, -59.22 91.02, -25.25 out-out-none SNCoon out-none ActLoopNT-out 6.657 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 172.6 APE9-dihe-in -105.91, 119.23 APE8-dihe-in -74.97, 58.92 APE8-rot-na 28.96 APE67-dihe-in -73.69, -0.36 -43.23, -49.45 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.935 APE9-dist-in 7.668 T790M,V948R None None XRAY 2.2 0.204 0.261 B 328 303 3 0 0 3 [[712, 970]] 1.0 8fv4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2RFDA P00533 703 1018 1210.0 No_ligand No_ligand Inactive DFGin 5.168 16.624 BLBtrans -126.59, 163.05 65.13, 46.33 -86.2, 138.52 145.4, 72.73 74.27, 0.85 out-out out 13.925 Saltbr-out 13.75 HRD-in -82.95, -54.79 88.4, -38.78 out-out-out SNCooo out-out ActLoopNT-out 6.675 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 120.67 APE9-dihe-in -92.29, 144.14 APE8-dihe-in -73.56, 103.24 APE8-rot-na 34.0 APE67-dihe-in -60.74, -31.07 -81.4, -44.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.277 APE9-dist-out 8.309 K823E None None XRAY 3.6 0.234 0.278 A 324 288 14 0 0 11 [[712, 970]] 1.0 2rfd Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2RFDB P00533 703 1018 1210.0 No_ligand No_ligand Inactive DFGin 4.798 16.048 BLBtrans -162.64, 174.09 64.27, 34.61 -66.47, 135.79 150.17, 58.46 39.76, 39.55 out-out out 14.551 Saltbr-out 14.591 HRD-in -87.58, -38.54 73.26, -40.51 out-out-out SNCooo out-out ActLoopNT-out 6.981 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -158.86, 162.54 APE9-dihe-in -151.43, 143.75 APE8-dihe-in -75.49, 85.44 APE8-rot-na 33.26 APE67-dihe-in -61.06, -19.22 -61.41, -32.59 APE12-dist-na 999.0 APE11-dist-na 14.137 APE10-dist-na 13.735 APE9-dist-out 8.341 K823E None None XRAY 3.6 0.234 0.278 B 324 286 12 0 0 8 [[712, 970]] 1.0 2rfd Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2RFEA P00533 702 1002 1210.0 No_ligand No_ligand Inactive DFGin 5.617 17.059 BLBtrans -126.07, 179.87 68.39, 3.88 -53.1, 130.92 165.63, 74.56 83.11, -16.61 out-out out 14.074 Saltbr-out 13.9 HRD-in -68.19, -58.25 85.2, -7.35 out-out-out SNCooo out-out ActLoopNT-out 7.529 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 169.37 APE9-dihe-in -153.82, 129.38 APE8-dihe-in -69.69, 55.01 APE8-rot-na 36.27 APE67-dihe-in -68.46, -8.85 -37.09, -46.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.019 APE9-dist-out 8.208 K823E None None XRAY 2.9 0.229 0.271 A 324 285 8 0 0 8 [[712, 970]] 1.0 2rfe Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2RFEB P00533 703 1012 1210.0 No_ligand No_ligand Inactive DFGin 5.547 16.821 BLBtrans -132.21, -179.96 69.1, 4.87 -54.39, 127.17 163.8, 72.34 86.16, -10.85 out-out out 14.149 Saltbr-out 13.706 HRD-in -70.46, -55.75 83.73, -11.44 out-out-out SNCooo out-out ActLoopNT-out 8.117 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 130.21 APE9-dihe-in -143.12, 137.45 APE8-dihe-in -71.16, 61.18 APE8-rot-na 39.12 APE67-dihe-in -74.49, -2.04 -48.16, -41.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.114 APE9-dist-out 8.386 K823E None None XRAY 2.9 0.229 0.271 B 324 273 11 0 0 11 [[712, 970]] 1.0 2rfe Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2RFEC P00533 702 983 1210.0 No_ligand No_ligand Inactive DFGin 5.429 16.838 BLBtrans -130.03, -176.46 64.15, 8.93 -57.23, 123.22 161.3, 70.99 105.16, -30.21 out-out out 13.896 Saltbr-out 13.655 HRD-in -74.31, -52.17 78.67, -3.86 out-out-out SNCooo out-out ActLoopNT-out 7.269 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 144.94 APE9-dihe-in -133.96, 136.3 APE8-dihe-in -70.77, 58.99 APE8-rot-na 32.18 APE67-dihe-in -75.34, 9.03 -46.34, -40.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.603 APE9-dist-out 8.072 K823E None None XRAY 2.9 0.229 0.271 C 324 262 20 0 0 11 [[712, 970]] 1.0 2rfe Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2RFED P00533 703 1018 1210.0 No_ligand No_ligand Inactive DFGin 5.25 16.653 BLBtrans -125.7, 174.95 73.25, 5.66 -51.33, 131.77 165.42, 64.15 87.01, -8.38 out-out out 14.409 Saltbr-out 13.43 HRD-in -76.96, -58.59 84.17, -6.71 out-out-out SNCooo out-out ActLoopNT-out 7.326 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 131.37 APE9-dihe-in -130.04, 137.41 APE8-dihe-in -68.34, 54.24 APE8-rot-na 34.22 APE67-dihe-in -67.2, -1.76 -41.17, -50.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.21 APE9-dist-out 8.062 K823E None None XRAY 2.9 0.229 0.271 D 324 278 14 0 0 11 [[712, 970]] 1.0 2rfe Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V66A P00533 701 1014 1210.0 QP1:1202 Type1 Inactive DFGin 5.426 16.514 BLBtrans -124.42, 177.95 61.86, 22.75 -59.98, 134.04 162.48, 75.29 88.51, -14.09 out-out out 14.22 Saltbr-out 14.194 HRD-in -77.47, -52.32 80.43, -9.63 out-out-out SNCooo out-out ActLoopNT-out 6.728 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.38, -13.47 APE9-dihe-in -92.56, 110.16 APE8-dihe-in -84.07, 69.49 APE8-rot-na 34.36 APE67-dihe-in -75.03, -2.7 -49.4, -44.98 APE12-dist-na 15.483 APE11-dist-na 13.333 APE10-dist-na 9.108 APE9-dist-in 7.409 T790M,V948R None None XRAY 1.79 0.187 0.226 A 327 314 0 0 0 0 [[712, 970]] 1.0 6v66 Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V66B P00533 701 1014 1210.0 QP1:1202 Type1 Inactive DFGin 5.419 16.392 BLBtrans -126.49, 176.29 67.7, 20.21 -61.15, 136.48 152.37, 70.68 83.55, -13.04 out-out out 13.94 Saltbr-out 13.622 HRD-in -79.19, -50.94 79.82, -14.47 out-out-out SNCooo out-out ActLoopNT-out 6.943 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 5.96 APE9-dihe-in -124.61, 120.95 APE8-dihe-in -80.22, 74.26 APE8-rot-na 32.87 APE67-dihe-in -76.34, -6.09 -59.72, -39.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.496 APE9-dist-out 8.123 T790M,V948R None None XRAY 1.79 0.187 0.226 B 327 302 12 0 0 12 [[712, 970]] 1.0 6v66 Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V66C P00533 701 1012 1210.0 QP1:1101 Type1 Inactive DFGin 5.717 16.359 BLBtrans -124.4, -178.87 63.87, 27.71 -73.72, 147.34 167.32, 74.76 78.96, -14.16 out-out out 13.351 Saltbr-out 12.617 HRD-in -80.32, -46.75 78.9, -11.66 out-out-none SNCoon out-none ActLoopNT-out 7.109 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.19 APE8-dihe-in -84.45, 72.53 APE8-rot-na 33.88 APE67-dihe-in -72.73, -2.16 -59.44, -40.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.949 T790M,V948R None None XRAY 1.79 0.187 0.226 C 327 299 13 0 0 13 [[712, 970]] 1.0 6v66 Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V6KB P00533 700 1014 1210.0 QQJ:1202 Type1 Inactive DFGin 5.446 16.677 BLBtrans -120.08, 174.38 67.53, 23.96 -61.85, 141.71 152.32, 75.87 78.49, -9.92 out-out out 13.799 Saltbr-out 12.459 HRD-in -73.15, -55.56 80.97, -11.2 out-out-none SNCoon out-none ActLoopNT-out 6.793 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 70.83 APE8-rot-na 32.65 APE67-dihe-in -71.54, -3.4 -53.97, -47.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 2.2 0.215 0.239 B 327 301 14 0 0 14 [[712, 970]] 1.0 6v6k Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V6KE P00533 701 1014 1210.0 QQJ:1202 Type1 Inactive DFGin 5.091 16.031 BLBtrans -122.64, 177.93 70.8, 11.32 -64.29, 136.62 145.68, 77.64 104.91, -23.54 out-out out 13.566 Saltbr-out 12.95 HRD-in -74.97, -57.13 87.56, -9.8 out-out-none SNCoon out-none ActLoopNT-out 6.785 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 103.34 APE8-dihe-in -72.02, 69.2 APE8-rot-na 28.12 APE67-dihe-in -72.14, 1.74 -55.9, -45.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.954 T790M,V948R None None XRAY 2.2 0.215 0.239 E 327 303 11 0 0 11 [[712, 970]] 1.0 6v6k Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V6KH P00533 701 1014 1210.0 QQJ:1202 Type1 Inactive DFGin 5.38 16.617 BLBtrans -122.23, -176.76 60.52, 24.13 -72.16, 137.8 149.6, 82.13 84.24, -7.03 out-out out 14.463 Saltbr-out 16.568 HRD-in -71.15, -55.32 82.36, -11.57 out-out-out SNCooo out-out ActLoopNT-out 6.532 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -89.11, -2.11 APE9-dihe-in -99.5, 119.67 APE8-dihe-in -81.25, 72.47 APE8-rot-na 35.55 APE67-dihe-in -80.47, -1.73 -53.94, -37.54 APE12-dist-na 18.705 APE11-dist-na 16.028 APE10-dist-na 11.677 APE9-dist-out 8.114 T790M,V948R None None XRAY 2.2 0.215 0.239 H 327 314 0 0 0 0 [[712, 970]] 1.0 6v6k Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V6OA P00533 701 1007 1210.0 QQM:1202 Type1 Inactive DFGin 5.298 16.727 BLBtrans -121.65, 172.71 69.64, 21.71 -62.97, 137.24 151.72, 75.2 80.63, -10.98 out-out out 14.391 Saltbr-out 13.42 HRD-in -75.85, -53.93 83.31, -13.79 out-out-out SNCooo out-out ActLoopNT-out 6.809 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.46, -8.8 APE9-dihe-in -105.55, 118.94 APE8-dihe-in -80.71, 68.41 APE8-rot-na 31.83 APE67-dihe-in -75.0, -4.07 -53.04, -43.94 APE12-dist-na 17.172 APE11-dist-na 14.893 APE10-dist-na 10.703 APE9-dist-in 7.811 T790M,V948R None None XRAY 2.1 0.196 0.221 A 327 307 0 0 0 0 [[712, 970]] 1.0 6v6o Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V6OB P00533 701 1014 1210.0 QQM:1202 Type1 Inactive DFGin 5.753 16.86 BLBtrans -121.27, 172.7 70.02, 21.31 -63.98, 138.97 154.89, 75.61 80.68, -11.77 out-out out 14.192 Saltbr-out 13.383 HRD-in -75.47, -53.91 84.16, -12.57 out-out-out SNCooo out-out ActLoopNT-out 6.456 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -76.92, -9.63 APE9-dihe-in -88.61, 118.08 APE8-dihe-in -81.24, 68.33 APE8-rot-na 32.0 APE67-dihe-in -74.5, -4.48 -53.39, -42.67 APE12-dist-na 18.881 APE11-dist-na 15.887 APE10-dist-na 11.381 APE9-dist-out 8.301 T790M,V948R None None XRAY 2.1 0.196 0.221 B 327 314 0 0 0 0 [[712, 970]] 1.0 6v6o Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V6OF P00533 701 1012 1210.0 QQM:1202 Type1 Inactive DFGin 5.905 17.242 BLBtrans -120.46, 172.23 70.73, 22.19 -64.5, 139.46 157.13, 75.08 81.89, -12.08 out-out out 13.742 Saltbr-out 12.61 HRD-in -74.49, -52.75 85.72, -15.71 out-out-none SNCoon out-none ActLoopNT-out 6.811 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.82 APE8-dihe-in -82.55, 69.28 APE8-rot-na 31.97 APE67-dihe-in -74.52, -5.14 -52.67, -43.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.827 T790M,V948R None None XRAY 2.1 0.196 0.221 F 327 299 13 0 0 13 [[712, 970]] 1.0 6v6o Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V6OG P00533 701 1009 1210.0 QQM:1301 Type1 Inactive DFGin 5.55 16.214 BLBtrans -119.98, -175.83 64.58, 23.85 -74.9, 132.09 162.27, 73.99 101.97, 164.72 out-out out 13.363 Saltbr-out 11.572 HRD-in -77.28, -50.81 78.9, -9.78 out-out-none SNCoon out-none ActLoopNT-out 9.86 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.89 APE8-dihe-in -78.97, 76.25 APE8-rot-na 32.23 APE67-dihe-in -70.7, -0.71 -59.43, -44.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.947 T790M,V948R None None XRAY 2.1 0.196 0.221 G 327 294 15 0 0 15 [[712, 970]] 1.0 6v6o Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V5NB P00533 700 1008 1210.0 QP7:1101 Type1 Inactive DFGin 5.528 16.668 BLBtrans -119.94, 178.74 66.11, 18.96 -52.29, 130.24 160.73, 59.1 85.08, -2.96 out-out out 14.066 Saltbr-out 12.919 HRD-in -79.78, -55.13 78.99, -6.78 out-out-none SNCoon out-none ActLoopNT-out 6.762 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 9.17 APE9-dihe-in -103.02, 125.51 APE8-dihe-in -71.63, 72.68 APE8-rot-na 25.68 APE67-dihe-in -77.13, 1.99 -54.76, -38.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.768 APE9-dist-in 7.861 T790M,V948R None None XRAY 2.4 0.194 0.243 B 328 297 12 0 0 12 [[712, 970]] 1.0 6v5n Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V5NC P00533 701 1007 1210.0 QP7:1101 Type1 Inactive DFGin 6.173 17.209 BLBtrans -123.09, 177.25 64.84, 25.93 -67.2, 127.86 173.41, 73.29 98.01, -33.09 out-out out 13.843 Saltbr-out 12.806 HRD-in -77.86, -53.16 83.3, -4.81 out-out-out SNCooo out-out ActLoopNT-out 6.605 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.15 APE8-dihe-in -80.57, 70.35 APE8-rot-na 34.86 APE67-dihe-in -74.95, -1.76 -59.11, -43.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.194 T790M,V948R None None XRAY 2.4 0.194 0.243 C 328 294 13 0 0 13 [[712, 970]] 1.0 6v5n Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V5ND P00533 701 1008 1210.0 QP7:1101 Type1 Inactive DFGin 5.464 16.875 BLBtrans -122.79, 173.83 67.54, 11.62 -44.12, 126.51 166.91, 74.2 86.38, -8.67 out-out out 14.234 Saltbr-out 13.559 HRD-in -79.51, -49.19 78.66, -5.24 out-out-out SNCooo out-out ActLoopNT-out 6.933 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -72.76, -24.22 APE9-dihe-in -89.09, 115.08 APE8-dihe-in -83.81, 64.66 APE8-rot-na 32.09 APE67-dihe-in -75.96, 5.83 -39.75, -53.8 APE12-dist-na 16.003 APE11-dist-na 13.192 APE10-dist-na 9.024 APE9-dist-in 7.333 T790M,V948R None None XRAY 2.4 0.194 0.243 D 328 308 0 0 0 0 [[712, 970]] 1.0 6v5n Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V5PB P00533 701 1012 1210.0 QP4:1101 Type1 Inactive DFGin 5.303 16.35 BLBtrans -118.73, 170.65 71.18, 16.69 -51.79, 134.25 157.01, 66.81 84.4, -8.65 out-out out 13.951 Saltbr-out 13.315 HRD-in -75.9, -58.94 89.67, -12.03 out-out-out SNCooo out-out ActLoopNT-out 6.666 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.92 APE8-dihe-in -85.33, 67.36 APE8-rot-na 31.73 APE67-dihe-in -71.82, -2.95 -53.08, -40.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.089 T790M,V948R None None XRAY 2.3 0.18 0.194 B 328 299 13 0 0 13 [[712, 970]] 1.0 6v5p Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V5PC P00533 701 1008 1210.0 QP4:1101 Type1 Inactive DFGin 5.83 16.755 BLBtrans -115.52, 179.63 64.16, 24.84 -64.39, 139.3 166.3, 74.9 85.47, -20.18 out-out out 13.606 Saltbr-out 13.882 HRD-in -73.77, -54.08 87.02, -8.4 out-out-none SNCoon out-none ActLoopNT-out 6.406 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.59 APE8-dihe-in -84.44, 72.48 APE8-rot-na 36.56 APE67-dihe-in -75.91, -4.6 -60.99, -34.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.988 T790M,V948R None None XRAY 2.3 0.18 0.194 C 328 295 13 0 0 13 [[712, 970]] 1.0 6v5p Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6V5PD P00533 701 1008 1210.0 QP4:1101 Type1 Inactive DFGin 5.46 16.564 BLBtrans -120.28, 175.29 66.46, 14.28 -49.73, 134.24 162.88, 82.49 92.29, -24.11 out-out out 14.343 Saltbr-out 14.015 HRD-in -75.94, -55.12 90.57, -21.14 out-out-out SNCooo out-out ActLoopNT-out 6.809 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -65.99, -23.04 APE9-dihe-in -93.42, 113.55 APE8-dihe-in -81.58, 67.98 APE8-rot-na 34.43 APE67-dihe-in -70.62, -1.7 -51.12, -49.96 APE12-dist-na 15.187 APE11-dist-na 13.359 APE10-dist-na 9.332 APE9-dist-in 7.511 T790M,V948R None None XRAY 2.3 0.18 0.194 D 328 308 0 0 0 0 [[712, 970]] 1.0 6v5p Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7UKWB P00533 702 1010 1210.0 ZRT:1101 Type1 Inactive DFGin 5.685 16.047 BLBtrans -113.97, -161.81 58.02, 23.78 -82.99, 120.69 174.98, 81.16 148.01, -65.31 out-out out 13.055 Saltbr-out 14.431 HRD-in -77.09, -41.34 72.52, -21.33 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.74 APE8-dihe-in -77.84, 69.21 APE8-rot-na 30.93 APE67-dihe-in -73.33, 2.8 -53.59, -40.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.885 T790M,V948R None None XRAY 2.6 0.198 0.25 B 328 292 17 0 0 17 [[712, 970]] 1.0 7ukw Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7UKWC P00533 700 1005 1210.0 ZRT:1101 Type1 Inactive DFGin 4.989 15.935 BLBtrans -123.13, -177.75 72.13, 23.23 -82.62, 140.54 153.1, 70.99 83.68, 5.4 out-out out 13.458 Saltbr-out 14.542 HRD-in -89.97, -42.34 71.46, -11.24 out-out-none SNCoon out-none ActLoopNT-out 7.301 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 104.7 APE8-dihe-in -76.72, 75.0 APE8-rot-na 20.02 APE67-dihe-in -68.67, -13.51 -56.7, -40.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.852 T790M,V948R None None XRAY 2.6 0.198 0.25 C 328 287 19 0 0 13 [[712, 970]] 1.0 7ukw Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5X2AC P00533 700 1015 1210.0 7XO:1104 Type1 Inactive DFGin 5.504 16.539 BLBtrans -121.56, -177.75 69.47, 12.59 -60.5, 141.21 167.5, 68.5 89.76, -35.23 out-out out 13.565 Saltbr-out 13.137 HRD-in -66.9, -48.76 80.92, -13.83 out-out-out SNCooo out-out ActLoopNT-out 7.021 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.32 APE8-dihe-in -80.48, 64.62 APE8-rot-na 38.22 APE67-dihe-in -72.09, -6.11 -53.33, -40.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.214 T790M,V948R None None XRAY 1.85 0.176 0.219 C 331 303 13 0 0 13 [[712, 970]] 1.0 5x2a Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5X2CA P00533 700 1015 1210.0 7XR:1104 Type1 Inactive DFGin 5.521 16.244 BLBtrans -119.2, -173.9 68.01, 13.0 -61.53, 135.68 163.01, 80.32 88.29, -8.64 out-out out 13.736 Saltbr-out 12.844 HRD-in -81.15, -54.79 82.63, -11.78 out-out-out SNCooo out-out ActLoopNT-out 6.575 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 8.3 APE9-dihe-in -61.54, 131.22 APE8-dihe-in -85.76, 71.43 APE8-rot-na 36.24 APE67-dihe-in -67.14, -14.04 -60.63, -39.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.547 APE9-dist-out 8.325 T790M,V948R None None XRAY 2.05 0.175 0.202 A 331 304 12 0 0 12 [[712, 970]] 1.0 5x2c Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5X2CB P00533 701 1014 1210.0 7XR:1108 Type1 Inactive DFGin 5.614 16.533 BLBtrans -123.4, -172.44 64.48, 17.44 -63.31, 135.2 170.91, 82.18 86.12, -10.39 out-out out 13.935 Saltbr-out 13.402 HRD-in -68.72, -52.33 82.34, -14.55 out-out-out SNCooo out-out ActLoopNT-out 6.813 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -134.03 APE9-dihe-in -64.14, 138.31 APE8-dihe-in -88.3, 72.92 APE8-rot-na 37.78 APE67-dihe-in -73.91, -8.47 -60.44, -40.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.552 APE9-dist-out 8.569 T790M,V948R None None XRAY 2.05 0.175 0.202 B 331 303 11 0 0 11 [[712, 970]] 1.0 5x2c Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5X2FA P00533 700 1014 1210.0 7XU:3001 Type1 Inactive DFGin 5.277 16.448 BLBtrans -123.32, 172.02 76.25, 14.66 -63.1, 136.14 155.85, 76.2 93.55, -18.43 out-out out 13.903 Saltbr-out 13.521 HRD-in -64.37, -47.13 82.94, -11.58 out-out-out SNCooo out-out ActLoopNT-out 6.686 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -139.26 APE9-dihe-in -65.98, 137.84 APE8-dihe-in -86.71, 77.15 APE8-rot-na 28.13 APE67-dihe-in -65.36, -24.94 -60.66, -39.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.462 APE9-dist-out 8.371 T790M,V948R None None XRAY 2.2 0.204 0.24 A 331 301 12 0 0 12 [[712, 970]] 1.0 5x2f Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5X2FB P00533 699 1010 1210.0 7XU:1101 Type1 Inactive DFGin 5.475 16.751 BLBtrans -127.63, 167.89 80.54, 16.33 -63.02, 131.83 161.78, 84.37 83.6, -4.7 out-out out 14.234 Saltbr-out 13.829 HRD-in -67.38, -48.36 82.16, -11.42 out-out-out SNCooo out-out ActLoopNT-out 6.717 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -58.77, -35.5 APE9-dihe-in -81.98, 121.93 APE8-dihe-in -88.82, 74.84 APE8-rot-na 21.79 APE67-dihe-in -65.18, -22.17 -60.37, -39.04 APE12-dist-na 16.028 APE11-dist-na 13.825 APE10-dist-na 9.783 APE9-dist-in 7.662 T790M,V948R None None XRAY 2.2 0.204 0.24 B 331 312 0 0 0 0 [[712, 970]] 1.0 5x2f Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5X2FC P00533 700 1014 1210.0 7XU:1101 Type1 Inactive DFGin 5.528 16.589 BLBtrans -127.54, 178.33 71.1, 24.62 -67.94, 133.51 165.25, 78.29 84.95, -3.1 out-out out 13.776 Saltbr-out 13.057 HRD-in -67.71, -49.31 79.01, -3.44 out-out-none SNCoon out-none ActLoopNT-out 6.954 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 150.95 APE8-dihe-in -93.37, 90.33 APE8-rot-na 3.23 APE67-dihe-in -70.21, -14.78 -62.45, -39.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.638 T790M,V948R None None XRAY 2.2 0.204 0.24 C 331 302 13 0 0 13 [[712, 970]] 1.0 5x2f Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5X2FD P00533 697 1014 1210.0 7XU:1101 Type1 Inactive DFGin 5.498 16.498 BLBtrans -130.98, 165.88 79.98, 18.78 -66.39, 133.64 153.14, 81.34 83.33, -4.64 out-out out 14.276 Saltbr-out 14.481 HRD-in -63.96, -47.23 82.78, -10.18 out-out-out SNCooo out-out ActLoopNT-out 6.486 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -35.63 APE9-dihe-in -100.74, 141.55 APE8-dihe-in -86.44, 64.59 APE8-rot-na 29.63 APE67-dihe-in -73.4, -13.47 -53.45, -43.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.743 APE9-dist-out 8.389 T790M,V948R None None XRAY 2.2 0.204 0.24 D 331 309 7 0 0 7 [[712, 970]] 1.0 5x2f Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXIA P00533 700 1006 1210.0 8BS:1101 Type1 Inactive DFGin 6.002 16.539 BLBtrans -128.56, -179.35 55.18, 20.34 -72.14, 105.08 161.03, 82.24 -164.24, -136.24 out-out out 13.357 Saltbr-out 11.38 HRD-in -66.93, -56.02 77.07, -6.66 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.19 APE8-dihe-in -80.02, 70.1 APE8-rot-na 30.7 APE67-dihe-in -73.23, -5.24 -53.52, -45.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.479 T790M,V948R None None XRAY 3.0 0.278 0.312 A 331 290 17 0 0 17 [[712, 970]] 1.0 7jxi Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXID P00533 702 1006 1210.0 8BS:1101 Type1 Inactive DFGin 5.407 16.257 BLBtrans -129.42, 179.04 50.18, 64.39 -110.41, 142.47 148.26, 80.05 85.73, -1.43 out-out out 13.403 Saltbr-out 12.596 HRD-in -71.0, -57.45 77.99, -6.63 out-out-none SNCoon out-none ActLoopNT-out 9.223 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.12 APE8-dihe-in -80.19, 70.22 APE8-rot-na 30.77 APE67-dihe-in -72.81, -5.27 -53.35, -45.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.383 T790M,V948R None None XRAY 3.0 0.278 0.312 D 331 289 16 0 0 13 [[712, 970]] 1.0 7jxi Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXLA P00533 701 1013 1210.0 VO7:1101 Type1 Inactive DFGin 5.542 16.067 BLBtrans -126.4, -179.97 66.03, 31.68 -87.54, 145.45 161.25, 72.83 92.56, -6.61 out-out out 13.282 Saltbr-out 13.233 HRD-in -72.85, -58.8 84.46, -15.1 out-out-none SNCoon out-none ActLoopNT-out 9.348 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.61 APE8-dihe-in -82.4, 69.83 APE8-rot-na 33.22 APE67-dihe-in -77.96, -2.7 -53.21, -40.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.765 T790M,V948R None None XRAY 2.4 0.21 0.239 A 331 294 19 0 0 14 [[712, 970]] 1.0 7jxl Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7KY0B P00533 700 1007 1210.0 XA4:1101 Type1 Inactive DFGin 4.244 15.439 BLBtrans -160.57, 176.1 77.66, 59.27 -115.51, 105.39 132.91, 62.63 158.65, 57.76 out-out out 13.296 Saltbr-out 10.451 HRD-in -69.02, -53.59 81.26, -3.78 out-out-out SNCooo out-out ActLoopNT-out 9.281 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.26 APE8-dihe-in -79.51, 75.82 APE8-rot-na 31.83 APE67-dihe-in -75.32, -0.28 -59.99, -39.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.269 T790M,V948R None None XRAY 3.1 0.24 0.292 B 331 285 20 0 0 14 [[712, 970]] 1.0 7ky0 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7KY0D P00533 700 1007 1210.0 XA4:1101 Type1 Inactive DFGin 4.302 15.48 BLBtrans -138.98, -176.35 58.31, 55.74 -112.38, 119.92 126.22, 87.9 141.73, 45.73 out-out out 13.342 Saltbr-out 11.554 HRD-in -67.33, -55.84 83.95, -5.94 out-out-none SNCoon out-none ActLoopNT-out 9.101 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.65 APE8-dihe-in -83.77, 71.98 APE8-rot-na 32.22 APE67-dihe-in -72.87, -2.69 -55.69, -38.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.511 T790M,V948R None None XRAY 3.1 0.24 0.292 D 331 294 14 0 0 14 [[712, 970]] 1.0 7ky0 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7U98B P00533 701 1005 1210.0 M1O:1101 Type1 Inactive DFGin 5.609 16.611 BLBtrans -140.13, -174.53 48.89, 57.71 -85.81, 131.72 167.62, 55.27 65.83, 6.33 out-out out 13.577 Saltbr-out 13.535 HRD-in -76.37, -57.65 78.87, -5.89 out-out-out SNCooo out-out ActLoopNT-out 6.917 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 8.89 APE9-dihe-in -69.72, 140.24 APE8-dihe-in -81.34, 67.13 APE8-rot-na 31.34 APE67-dihe-in -70.75, -7.15 -60.08, -43.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.672 APE9-dist-out 8.23 T790M,V948R None None XRAY 3.42 0.216 0.244 B 331 293 12 0 0 12 [[712, 970]] 1.0 7u98 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7U98C P00533 702 1007 1210.0 M1O:1101 Type1 Inactive DFGin 5.084 16.301 BLBtrans -131.03, -174.08 58.46, 35.85 -67.66, 147.46 158.98, 69.58 40.61, 29.57 out-out out 13.611 Saltbr-out 12.985 HRD-in -71.79, -58.03 80.81, -14.3 out-out-out SNCooo out-out ActLoopNT-out 8.704 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.85 APE8-dihe-in -70.24, 67.11 APE8-rot-na 29.02 APE67-dihe-in -75.38, -2.45 -60.79, -40.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.302 T790M,V948R None None XRAY 3.42 0.216 0.244 C 331 286 20 0 0 14 [[712, 970]] 1.0 7u98 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7U98D P00533 701 1007 1210.0 M1O:1101 Type1 Inactive DFGin 5.734 16.43 BLBtrans -133.75, -174.31 52.82, 34.09 -65.47, 149.8 160.31, 69.84 72.06, -122.62 out-out out 13.719 Saltbr-out 13.804 HRD-in -70.87, -55.75 80.84, -15.72 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.2 APE8-dihe-in -87.12, 65.67 APE8-rot-na 32.02 APE67-dihe-in -75.78, -0.75 -61.11, -41.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.534 T790M,V948R None None XRAY 3.42 0.216 0.244 D 331 285 22 0 0 16 [[712, 970]] 1.0 7u98 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8F1WA P00533 701 1007 1210.0 R2E:1101 Type1 Inactive DFGin 5.28 16.379 BLBtrans -128.45, -172.46 54.26, 51.11 -103.7, 148.5 152.13, 74.45 76.8, -16.65 out-out out 13.469 Saltbr-out 13.206 HRD-in -72.99, -57.24 80.64, -5.91 out-out-out SNCooo out-out ActLoopNT-out 8.08 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -99.43, -53.06 APE9-dihe-in -72.87, 140.92 APE8-dihe-in -84.73, 81.02 APE8-rot-na 32.64 APE67-dihe-in -74.93, -2.07 -61.05, -46.98 APE12-dist-na 19.316 APE11-dist-na 16.495 APE10-dist-na 12.256 APE9-dist-in 7.556 T790M,V948R None None XRAY 3.2 0.233 0.274 A 331 303 4 0 0 4 [[712, 970]] 1.0 8f1w Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8F1WB P00533 700 1007 1210.0 R2E:1101 Type1 Inactive DFGin 4.358 15.734 BLBtrans -129.99, -174.05 52.25, 52.37 -111.11, 152.05 129.92, 81.6 82.17, -3.69 out-out out 13.437 Saltbr-out 14.463 HRD-in -72.48, -56.45 81.7, -6.34 out-out-none SNCoon out-none ActLoopNT-out 8.913 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.67 APE8-dihe-in -84.49, 80.46 APE8-rot-na 32.73 APE67-dihe-in -74.43, -1.94 -61.83, -47.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.727 T790M,V948R None None XRAY 3.2 0.233 0.274 B 331 288 17 0 0 14 [[712, 970]] 1.0 8f1w Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8F1WC P00533 700 1007 1210.0 R2E:1101 Type1 Inactive DFGin 5.411 16.33 BLBtrans -128.1, -172.08 53.52, 45.92 -101.71, 133.48 161.59, 77.0 98.24, -6.72 out-out out 13.166 Saltbr-out 13.462 HRD-in -72.8, -56.41 81.38, -6.01 out-out-none SNCoon out-none ActLoopNT-out 8.716 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.55 APE8-dihe-in -84.21, 80.52 APE8-rot-na 32.64 APE67-dihe-in -74.76, -1.9 -61.65, -47.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.682 T790M,V948R None None XRAY 3.2 0.233 0.274 C 331 290 18 0 0 14 [[712, 970]] 1.0 8f1w Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8F1WD P00533 700 1007 1210.0 R2E:1101 Type1 Inactive DFGin 5.365 16.324 BLBtrans -129.36, -171.8 54.41, 47.64 -102.11, 148.89 154.19, 76.79 83.64, -7.92 out-out out 13.848 Saltbr-out 18.195 HRD-in -72.16, -56.36 81.51, -6.86 out-out-out SNCooo out-out ActLoopNT-out 8.707 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.09, -47.67 APE9-dihe-in -78.16, 141.77 APE8-dihe-in -84.0, 80.49 APE8-rot-na 32.67 APE67-dihe-in -74.57, -2.54 -61.13, -46.62 APE12-dist-na 18.773 APE11-dist-na 15.914 APE10-dist-na 11.838 APE9-dist-in 7.585 T790M,V948R None None XRAY 3.2 0.233 0.274 D 331 304 4 0 0 4 [[712, 970]] 1.0 8f1w Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6Z4DA P00533 701 984 1210.0 8BS:1101 Type1 Inactive DFGin 5.582 16.911 BLBtrans -114.92, 175.53 65.11, 24.14 -66.3, 140.38 162.98, 75.92 74.11, -7.31 out-out out 14.215 Saltbr-out 12.826 HRD-in -79.35, -52.49 82.58, -13.07 out-out-out SNCooo out-out ActLoopNT-out 7.154 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.13 APE8-dihe-in -73.43, 66.21 APE8-rot-na 29.65 APE67-dihe-in -74.75, -4.91 -55.02, -43.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.316 T790M,V948R None None XRAY 2.0 0.195 0.221 A 333 269 15 0 0 13 [[712, 970]] 1.0 6z4d Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7A6JA P00533 699 982 1210.0 R2E:1101 Type1 Inactive DFGin 5.453 16.618 BLBtrans -120.02, 179.59 64.16, 32.38 -80.87, 139.28 157.53, 71.5 71.31, -7.23 out-out out 13.937 Saltbr-out 13.528 HRD-in -70.46, -55.09 81.28, -12.68 out-out-out SNCooo out-out ActLoopNT-out 8.076 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.23 APE8-dihe-in -79.55, 65.7 APE8-rot-na 33.45 APE67-dihe-in -69.43, -10.33 -53.39, -41.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.191 T790M,V948R None None XRAY 2.0 0.192 0.216 A 333 270 14 0 0 14 [[712, 970]] 1.0 7a6j Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7A6KA P00533 700 984 1210.0 R28:1101 Type1 Inactive DFGin 5.672 16.532 BLBtrans -113.38, -178.74 66.45, 17.22 -70.85, 135.38 162.57, 71.95 93.0, -13.33 out-out out 13.46 Saltbr-out 13.73 HRD-in -79.28, -53.26 81.06, -6.15 out-out-out SNCooo out-out ActLoopNT-out 7.541 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 9.43 APE9-dihe-in -71.11, 126.54 APE8-dihe-in -79.69, 67.98 APE8-rot-na 32.03 APE67-dihe-in -70.72, -4.33 -56.41, -46.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.919 APE9-dist-out 8.412 T790M,V948R None None XRAY 2.0 0.193 0.22 A 333 266 19 0 0 14 [[712, 970]] 1.0 7a6k Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7A6KB P00533 700 982 1210.0 R28:1101 Type1 Inactive DFGin 5.343 15.868 BLBtrans -129.04, -178.67 62.57, 21.81 -71.79, 126.77 154.84, 72.08 83.61, 999.0 out-none out 13.481 Saltbr-none 999.0 HRD-in -76.88, -46.01 73.74, -7.71 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 133.51 APE9-dihe-in -84.9, 130.78 APE8-dihe-in -77.41, 66.48 APE8-rot-na 31.07 APE67-dihe-in -72.33, -5.85 -61.23, -39.01 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.682 T790M,V948R None None XRAY 2.0 0.193 0.22 B 333 260 23 0 0 17 [[712, 970]] 1.0 7a6k Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7A6KC P00533 700 984 1210.0 R28:1101 Type1 Inactive DFGin 5.484 15.789 BLBtrans -131.64, -174.72 61.99, 29.43 -91.7, 131.8 164.71, 64.61 141.03, 999.0 out-none out 13.417 Saltbr-none 999.0 HRD-in -76.77, -47.52 68.03, -0.55 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -68.19 APE9-dihe-in -103.13, 125.01 APE8-dihe-in -86.91, 68.74 APE8-rot-na 26.28 APE67-dihe-in -74.92, -1.32 -57.04, -40.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.556 T790M,V948R None None XRAY 2.0 0.193 0.22 C 333 262 23 0 0 17 [[712, 970]] 1.0 7a6k Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7A6KD P00533 702 984 1210.0 R28:1101 Type1 Inactive DFGin 5.163 15.725 BLBtrans -125.34, -177.59 58.43, 37.54 -98.25, 128.03 151.98, 71.88 111.44, 999.0 out-out out 13.356 Saltbr-out 9.148 HRD-in -91.6, -48.16 65.02, 0.98 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.46 APE8-dihe-in -80.89, 70.4 APE8-rot-na 24.1 APE67-dihe-in -72.66, -6.51 -57.4, -40.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.69 T790M,V948R None None XRAY 2.0 0.193 0.22 D 333 255 28 0 0 18 [[712, 970]] 1.0 7a6k Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4I24A P00533 700 1014 1210.0 1C9:9001 Type1 Inactive DFGin 5.661 16.446 BLBtrans -124.79, -177.97 65.95, 19.32 -65.94, 134.77 167.42, 77.24 100.69, -25.94 out-out out 13.775 Saltbr-out 12.829 HRD-in -83.3, -47.74 80.82, -14.46 out-out-out SNCooo out-out ActLoopNT-out 6.554 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.29 APE8-dihe-in -74.66, 58.68 APE8-rot-na 28.63 APE67-dihe-in -76.18, -6.25 -49.37, -41.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.306 T790M None None XRAY 1.8 0.21 0.239 A 329 295 20 0 0 13 [[712, 970]] 1.0 4i24 Homo sapiens TYR_EGFR_HUMAN TYR 8.2e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4I24B P00533 700 1014 1210.0 1C9:9001 Type1 Inactive DFGin 5.538 16.502 BLBtrans -127.49, -179.81 73.27, 11.54 -60.91, 132.74 167.82, 75.33 94.21, -14.75 out-out out 14.01 Saltbr-out 12.566 HRD-in -82.33, -49.07 80.92, -16.04 out-out-out SNCooo out-out ActLoopNT-out 6.75 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -77.49, -14.51 APE9-dihe-in -107.27, 109.9 APE8-dihe-in -79.94, 72.64 APE8-rot-na 30.26 APE67-dihe-in -75.43, -3.71 -52.62, -43.52 APE12-dist-na 999.0 APE11-dist-na 13.81 APE10-dist-na 9.903 APE9-dist-in 7.489 T790M None None XRAY 1.8 0.21 0.239 B 329 304 11 0 0 11 [[712, 970]] 1.0 4i24 Homo sapiens TYR_EGFR_HUMAN TYR 8.2e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5YU9A P00533 700 1017 1210.0 1E8:1101 Type1 Inactive DFGin 5.636 16.954 BLBtrans -125.21, 170.75 68.2, 24.35 -60.36, 133.88 165.48, 79.68 84.64, -7.33 out-out out 14.105 Saltbr-out 13.516 HRD-in -68.25, -48.62 80.2, -8.38 out-out-out SNCooo out-out ActLoopNT-out 6.623 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -1.9 APE9-dihe-in -68.14, 141.09 APE8-dihe-in -83.65, 70.23 APE8-rot-na 33.58 APE67-dihe-in -73.94, -5.17 -61.14, -38.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.164 APE9-dist-out 8.325 T790M None None XRAY 1.95 0.203 0.222 A 331 302 16 0 0 12 [[712, 970]] 1.0 5yu9 Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5YU9B P00533 699 1011 1210.0 1E8:1101 Type1 Inactive DFGin 5.578 16.845 BLBtrans -112.64, 177.79 63.79, 24.69 -63.05, 134.78 163.6, 79.76 84.83, -6.07 out-out out 14.134 Saltbr-out 14.101 HRD-in -68.46, -48.55 81.72, -13.78 out-out-out SNCooo out-out ActLoopNT-out 6.519 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.76 APE8-dihe-in -84.19, 72.46 APE8-rot-na 28.56 APE67-dihe-in -69.8, -15.04 -60.51, -37.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.185 T790M None None XRAY 1.95 0.203 0.222 B 331 295 18 0 0 13 [[712, 970]] 1.0 5yu9 Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5YU9C P00533 697 1021 1210.0 1E8:1101 Type1 Inactive DFGin 5.67 16.652 BLBtrans -122.9, 169.66 70.91, 24.34 -64.7, 134.43 166.29, 81.69 95.85, -22.56 out-out out 13.826 Saltbr-out 13.722 HRD-in -69.25, -50.19 81.18, -12.38 out-out-out SNCooo out-out ActLoopNT-out 6.805 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 107.02 APE9-dihe-in -132.02, 145.19 APE8-dihe-in -82.44, 66.61 APE8-rot-na 16.92 APE67-dihe-in -75.02, -8.16 -59.33, -36.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.992 APE9-dist-out 8.462 T790M None None XRAY 1.95 0.203 0.222 C 331 306 16 0 0 12 [[712, 970]] 1.0 5yu9 Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5YU9D P00533 700 1012 1210.0 1E8:1101 Type1 Inactive DFGin 5.71 16.766 BLBtrans -121.88, 171.32 72.04, 19.53 -55.62, 135.13 163.77, 67.42 83.7, -13.08 out-out out 13.758 Saltbr-out 13.361 HRD-in -69.57, -49.84 80.09, -14.78 out-out-out SNCooo out-out ActLoopNT-out 6.597 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 151.91 APE8-dihe-in -82.51, 73.37 APE8-rot-na 30.07 APE67-dihe-in -70.37, -12.42 -60.68, -39.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.027 T790M None None XRAY 1.95 0.203 0.222 D 331 300 13 0 0 13 [[712, 970]] 1.0 5yu9 Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4I22A P00533 700 1014 1210.0 IRE:9001 Type1 Inactive DFGin 5.463 16.472 BLBtrans -123.06, -178.62 68.31, 18.86 -65.27, 136.35 169.35, 71.91 94.28, -11.28 out-out out 13.657 Saltbr-out 12.177 HRD-in -84.17, -49.73 82.39, -10.75 out-out-out SNCooo out-out ActLoopNT-out 7.105 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.61 APE8-dihe-in -75.03, 69.55 APE8-rot-na 29.55 APE67-dihe-in -78.29, -2.11 -50.24, -41.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.297 T790M,L858R,V948R None None XRAY 1.71 0.198 0.224 A 329 297 18 0 0 13 [[712, 970]] 1.0 4i22 Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9GC6A P00533 698 1014 1210.0 A1IZ9:1101 Type1 Inactive DFGin 5.957 16.941 BLBtrans -113.12, 175.88 60.62, 26.23 -63.47, 128.84 168.58, 71.18 91.95, -9.99 out-out out 14.335 Saltbr-out 14.537 HRD-in -71.17, -49.86 79.87, -17.21 out-out-none SNCoon out-none ActLoopNT-out 6.959 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 106.41 APE8-dihe-in -75.37, 66.64 APE8-rot-na 32.21 APE67-dihe-in -70.19, -10.44 -46.86, -45.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.769 V948R None None XRAY 1.901 0.269 0.323 A 330 298 19 0 0 14 [[712, 970]] 1.0 9gc6 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9GC6B P00533 698 1014 1210.0 A1IZ9:1101 Type1 Inactive DFGin 6.022 16.945 BLBtrans -106.07, 175.04 65.48, 26.54 -65.44, 134.22 173.29, 73.76 87.47, -11.31 out-out out 14.006 Saltbr-out 14.543 HRD-in -70.88, -46.09 77.35, -9.72 out-out-none SNCoon out-none ActLoopNT-out 6.972 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 53.82 APE8-rot-na 32.21 APE67-dihe-in -63.66, -17.55 -53.54, -40.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V948R None None XRAY 1.901 0.269 0.323 B 330 300 17 0 0 14 [[712, 970]] 1.0 9gc6 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9GDVA P00533 702 985 1210.0 Q6K:1101 Type1 Inactive DFGin 5.61 15.829 BLBtrans -107.73, 177.69 65.5, 33.1 -82.9, 128.34 164.87, 70.16 94.26, -7.41 out-none out 12.642 Saltbr-none 999.0 HRD-in -75.43, -53.65 76.33, -6.74 none-out-none SNCnon out-none ActLoopNT-out 7.915 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 143.05 APE8-dihe-in -77.71, 68.12 APE8-rot-na 28.54 APE67-dihe-in -70.85, -6.5 -47.64, -45.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.734 V948R None None XRAY 2.218 0.235 0.293 A 330 262 22 0 0 15 [[712, 970]] 1.0 9gdv Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9GDVB P00533 702 985 1210.0 Q6K:1101 Type1 Inactive DFGin 4.579 15.491 BLBtrans -111.43, 179.21 66.37, 26.18 -74.59, 129.04 147.85, 63.03 60.16, 37.36 out-none out 12.538 Saltbr-none 999.0 HRD-out -124.5, 90.89 -69.11, -17.02 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 149.32 APE8-dihe-in -80.3, 68.77 APE8-rot-na 2.98 APE67-dihe-in -69.33, -16.36 -50.05, -40.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.271 V948R None None XRAY 2.218 0.235 0.293 B 330 267 17 0 0 17 [[712, 970]] 1.0 9gdv Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4HJOA P00533 703 984 1210.0 AQ4:61001 Type1 Inactive DFGin 5.388 16.318 BLBtrans -124.68, 174.05 69.43, 22.17 -65.94, 132.43 169.63, 65.82 88.49, -10.45 out-out out 13.639 Saltbr-out 13.3 HRD-in -64.45, -47.69 77.22, -1.5 out-out-out SNCooo out-out ActLoopNT-out 6.744 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -74.38, 153.06 APE9-dihe-in -116.04, 141.68 APE8-dihe-in -81.16, 64.87 APE8-rot-na 343.76 APE67-dihe-in -72.42, -1.21 -62.83, -39.56 APE12-dist-na 16.454 APE11-dist-na 13.108 APE10-dist-na 13.885 APE9-dist-out 8.594 V948R None None XRAY 2.75 0.231 0.253 A 337 278 4 0 0 0 [[712, 970]] 1.0 4hjo Homo sapiens TYR_EGFR_HUMAN TYR 8.7e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6JXTA P00533 697 984 1210.0 YY3:1101 Type1 Inactive DFGin 5.195 16.591 BLBtrans -111.23, 162.67 71.78, 29.16 -65.79, 134.38 147.38, 75.02 84.23, -1.16 out-out out 13.295 Saltbr-out 13.347 HRD-in -69.01, -50.38 82.25, -13.8 out-out-in SNCooi out-in ActLoopNT-out 7.742 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.48, 149.35 APE9-dihe-in -133.32, 157.03 APE8-dihe-in -83.78, 82.27 APE8-rot-na 27.63 APE67-dihe-in -60.52, -27.7 -61.29, -42.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.584 APE9-dist-in 7.368 E865A,E866A,K867A None None XRAY 2.307 0.218 0.239 A 331 284 4 0 0 2 [[712, 970]] 1.0 6jxt Homo sapiens TYR_EGFR_HUMAN TYR 5.8e-87 297.3 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5X2AB P00533 700 1022 1210.0 7XO:1105,ANP:1106 Type1,ATPlike Inactive DFGin 5.521 16.379 BLBtrans -118.08, 178.13 68.28, 22.21 -63.57, 132.1 161.37, 67.84 99.95, -15.3 out-out out 13.892 Saltbr-out 13.505 HRD-in -67.87, -49.57 81.65, -13.01 out-out-out SNCooo out-out ActLoopNT-out 6.364 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -63.35, -22.61 APE9-dihe-in -95.03, 108.56 APE8-dihe-in -83.98, 72.85 APE8-rot-na 21.28 APE67-dihe-in -71.39, -9.89 -59.75, -39.3 APE12-dist-na 15.726 APE11-dist-na 13.245 APE10-dist-na 9.274 APE9-dist-in 7.568 T790M,V948R None None XRAY 1.85 0.176 0.219 B 331 322 0 0 0 0 [[712, 970]] 1.0 5x2a Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5X2AA P00533 700 1011 1210.0 7XO:1107,ANP:1108 Type1,Allosteric Inactive DFGin 5.565 16.303 BLBtrans -120.52, 179.71 70.51, 14.21 -61.87, 136.6 165.52, 70.66 90.66, -18.93 out-out out 13.778 Saltbr-out 13.104 HRD-in -79.48, -46.8 73.07, -8.08 out-out-none SNCoon out-none ActLoopNT-out 6.728 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.51 APE8-dihe-in -84.48, 76.35 APE8-rot-na 26.1 APE67-dihe-in -71.21, -12.48 -60.14, -38.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.762 T790M,V948R None None XRAY 1.85 0.176 0.219 A 331 297 13 0 0 13 [[712, 970]] 1.0 5x2a Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9GC5A P00533 699 1012 1210.0 A1IZ8:1101 Type1.5_Back Inactive DFGin 5.6 16.79 BLBtrans -111.5, 178.08 56.68, 33.75 -72.61, 130.73 159.77, 72.21 91.77, -17.39 out-out out 13.965 Saltbr-out 14.411 HRD-in -70.39, -48.68 78.33, -15.6 out-out-none SNCoon out-none ActLoopNT-out 7.191 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.89 APE8-dihe-in -80.7, 65.69 APE8-rot-na 33.21 APE67-dihe-in -72.03, -12.63 -42.92, -46.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.813 V948R None None XRAY 1.909 0.222 0.261 A 330 300 14 0 0 14 [[712, 970]] 1.0 9gc5 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9GC5B P00533 699 1012 1210.0 A1IZ8:1101 Type1.5_Back Inactive DFGin 5.661 16.654 BLBtrans -109.72, -178.6 59.87, 20.79 -66.15, 129.46 164.43, 72.22 95.52, -21.82 out-out out 13.959 Saltbr-out 13.791 HRD-in -73.8, -49.03 79.45, -14.18 out-out-none SNCoon out-none ActLoopNT-out 6.897 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.92 APE8-dihe-in -77.6, 64.28 APE8-rot-na 29.47 APE67-dihe-in -68.23, -11.21 -44.13, -46.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.961 V948R None None XRAY 1.909 0.222 0.261 B 330 300 14 0 0 14 [[712, 970]] 1.0 9gc5 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8PO3A P00533 706 1001 1210.0 2II:1101 Type1.5_Front Inactive DFGin 5.664 17.494 BLBtrans -107.39, 172.75 67.19, 30.39 -61.3, 132.08 163.82, 77.02 76.73, -7.92 out-out out 15.498 Saltbr-out 15.217 HRD-in -73.05, -52.43 81.25, -11.07 out-out-out SNCooo out-out ActLoopNT-out 6.766 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.29 APE8-dihe-in -83.1, 70.29 APE8-rot-na 33.27 APE67-dihe-in -73.75, -3.18 -47.3, -43.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.215 V948R None None XRAY 2.13 0.222 0.269 A 330 279 13 0 0 13 [[712, 970]] 1.0 8po3 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4RIWB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.947 14.509 None -144.94, -140.84 60.54, -94.56 67.75, 16.38 293.55, 125.63 -72.75, -24.64 in-in in 8.962 Saltbr-in 2.577 HRD-out -81.5, 87.13 -71.92, 10.44 in-in-none SNCiin in-none ActLoopNT-in 2.914 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.11 APE8-dihe-in -64.72, 105.47 APE8-rot-na 338.81 APE67-dihe-in -78.09, 0.73 -66.98, -35.92 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.339 V948R,F997A,L1001A None None XRAY 3.1 0.233 0.287 B 345 293 4 0 0 4 [[712, 970]] 1.0 4riw Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4RIWD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 6.016 14.399 None -147.43, -141.55 60.24, -94.38 68.1, 17.38 294.17, 126.48 -72.23, -23.22 in-in in 8.845 Saltbr-in 3.081 HRD-in -78.23, -46.1 60.09, 5.38 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.64, 111.47 APE9-dihe-in -129.74, 134.09 APE8-dihe-in -62.84, 106.17 APE8-rot-na 337.89 APE67-dihe-in -78.37, 3.33 -65.15, -34.97 APE12-dist-na 11.397 APE11-dist-na 9.946 APE10-dist-na 9.723 APE9-dist-in 6.015 V948R,F997A,L1001A None None XRAY 3.1 0.233 0.287 D 345 297 0 0 0 0 [[712, 970]] 1.0 4riw Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4RIXB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.919 14.579 None -139.87, -153.46 71.8, -106.42 74.55, 12.91 300.13, 117.16 -73.01, -18.89 in-in in 8.778 Saltbr-in 2.851 HRD-out -79.93, 91.22 -73.37, 9.67 in-in-none SNCiin in-none ActLoopNT-in 2.815 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.04 APE8-dihe-in -57.54, 105.82 APE8-rot-na 336.15 APE67-dihe-in -83.65, 5.55 -71.82, -34.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.644 V948R,F997A,L1001A None None XRAY 3.1 0.21 0.258 B 345 293 4 0 0 4 [[712, 970]] 1.0 4rix Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4RIXD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.984 14.396 None -138.76, -155.76 70.86, -102.17 73.98, 14.44 299.1, 114.44 -71.0, -18.03 in-in in 8.433 Saltbr-in 2.13 HRD-in -75.74, -46.31 59.89, 5.04 in-in-in SNCiii in-in ActLoopNT-in 2.879 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.43, 115.77 APE9-dihe-in -128.43, 136.25 APE8-dihe-in -57.6, 106.59 APE8-rot-na 335.5 APE67-dihe-in -81.04, 4.3 -70.58, -32.32 APE12-dist-na 11.336 APE11-dist-na 10.144 APE10-dist-na 10.428 APE9-dist-in 5.987 V948R,F997A,L1001A None None XRAY 3.1 0.21 0.258 D 345 297 0 0 0 0 [[712, 970]] 1.0 4rix Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4RIYB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.952 14.655 None -154.99, 131.23 -173.19, -76.87 64.96, 12.46 300.69, 132.23 -71.94, -28.32 in-in in 8.685 Saltbr-in 2.95 HRD-out -79.99, 96.69 -77.78, 9.7 in-in-none SNCiin in-none ActLoopNT-in 2.884 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.59 APE8-dihe-in -76.15, 93.2 APE8-rot-na 346.43 APE67-dihe-in -79.33, 6.83 -64.49, -46.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.35 V948R,F997A,L1001A None None XRAY 2.981 0.221 0.267 B 345 293 4 0 0 4 [[712, 970]] 1.0 4riy Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4RIYD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.892 14.398 None -146.72, -160.68 90.34, -82.61 63.94, 14.36 297.22, 112.71 -69.53, -27.12 in-in in 8.333 Saltbr-in 2.327 HRD-in -73.91, -45.57 61.02, 4.8 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.34, 113.28 APE9-dihe-in -130.38, 137.58 APE8-dihe-in -69.37, 99.85 APE8-rot-na 344.82 APE67-dihe-in -75.56, 6.57 -58.1, -42.52 APE12-dist-na 11.232 APE11-dist-na 10.201 APE10-dist-na 9.961 APE9-dist-in 6.258 V948R,F997A,L1001A None None XRAY 2.981 0.221 0.267 D 345 297 0 0 0 0 [[712, 970]] 1.0 4riy Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8EMEA P00533 700 1007 1210.0 No_ligand No_ligand Inactive DFGin 3.986 13.839 None -137.24, 168.8 64.53, 119.38 -177.18, 999.0 59.37, 99.1 999.0, 999.0 out-out out 13.889 Saltbr-out 11.311 HRD-none 999.0, 999.0 999.0, 84.53 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -73.83, -4.04 999.0, -46.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 3.32 0.285 0.318 A 331 267 31 0 0 21 [[712, 970]] 1.0 8eme Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3GOPA P00533 676 1018 1210.0 No_ligand No_ligand Inactive DFGin 5.906 14.618 None -81.86, 151.27 -44.37, 145.0 -81.84, 77.36 22.41, 114.96 178.29, 999.0 in-na in 8.85 Saltbr-na 999.0 HRD-in -65.46, -52.27 80.15, -7.53 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.74 APE8-dihe-in -83.3, 83.47 APE8-rot-na 22.34 APE67-dihe-in -72.58, -12.26 -49.6, -41.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.954 K745M None None XRAY 2.8 0.213 0.259 A 361 300 29 0 0 18 [[712, 970]] 1.0 3gop Homo sapiens TYR_EGFR_HUMAN TYR 3.2e-86 295.0 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7JXIB P00533 702 1004 1210.0 8BS:1101 Type1 Inactive DFGin 4.641 14.267 None -127.65, -24.47 -127.47, 108.69 -144.39, 139.56 46.55, 108.56 -178.57, -134.7 out-out out 13.417 Saltbr-out 12.201 HRD-in -66.29, -55.89 76.11, -7.1 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.37 APE8-dihe-in -80.39, 70.42 APE8-rot-na 30.87 APE67-dihe-in -73.29, -5.7 -53.51, -46.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.511 T790M,V948R None None XRAY 3.0 0.278 0.312 B 331 274 25 0 0 17 [[712, 970]] 1.0 7jxi Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7KY0C P00533 700 1007 1210.0 XA4:1101 Type1 Inactive DFGin 5.795 16.213 None -140.43, -171.69 57.16, 56.26 -102.57, 14.47 175.77, 70.43 -64.23, -166.18 out-out out 13.304 Saltbr-out 13.711 HRD-in -68.5, -58.2 83.04, -5.79 out-out-none SNCoon out-none ActLoopNT-out 7.955 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.7 APE8-dihe-in -78.4, 79.01 APE8-rot-na 31.55 APE67-dihe-in -75.24, -1.85 -59.7, -43.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.59 T790M,V948R None None XRAY 3.1 0.24 0.292 C 331 289 19 0 0 14 [[712, 970]] 1.0 7ky0 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7U98A P00533 701 1007 1210.0 M1O:1101 Type1 Inactive DFGin 5.292 16.461 None -131.78, -176.31 58.71, 37.78 -55.07, -79.17 157.63, 65.72 -77.42, -26.86 out-out out 13.976 Saltbr-out 14.699 HRD-in -68.9, -54.72 82.24, -14.81 out-out-none SNCoon out-none ActLoopNT-out 7.121 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.12 APE8-rot-na 30.49 APE67-dihe-in -75.19, -1.88 -59.47, -39.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 3.42 0.216 0.244 A 331 287 20 0 0 14 [[712, 970]] 1.0 7u98 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7ZYQB P00533 700 984 1210.0 V58:1101 Type1 Inactive DFGin 5.144 13.295 None -125.84, 171.99 57.78, 57.18 -116.53, 999.0 63.4, 95.28 999.0, 999.0 out-out out 12.868 Saltbr-out 9.546 HRD-in -76.02, -55.26 80.29, -12.9 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.05 APE8-dihe-in -82.27, 69.03 APE8-rot-na 30.38 APE67-dihe-in -72.67, -5.58 -56.39, -41.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.47 T790M,V948R None None XRAY 2.1 0.199 0.223 B 333 260 25 0 0 19 [[712, 970]] 1.0 7zyq Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2JIVA P00533 700 984 1210.0 HKI:1797 Type1.5_Back Inactive DFGin 5.403 14.133 None -99.08, 179.7 43.08, 110.41 179.69, 142.51 59.42, 1.67 76.47, 0.27 out-out out 13.396 Saltbr-out 10.108 HRD-in -70.42, -63.2 89.91, -17.22 out-out-none SNCoon out-none ActLoopNT-out 6.928 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -38.75 APE9-dihe-in -107.53, 155.69 APE8-dihe-in -72.57, 63.91 APE8-rot-na 32.44 APE67-dihe-in -65.29, 3.74 -54.81, -43.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.932 APE9-dist-in 7.634 T790M None None XRAY 3.5 0.253 0.284 A 328 270 15 0 0 14 [[712, 970]] 1.0 2jiv Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8H7XB P00533 697 1018 1210.0 No_ligand No_ligand Inactive DFGinter 8.474 4.539 None -64.56, 138.69 -118.16, 46.75 -84.7, 147.88 264.74, 132.9 65.94, 48.18 in-in in 7.861 Saltbr-in 2.743 HRD-in -95.26, -40.89 71.41, -6.98 in-out-none SNCion out-none ActLoopNT-out 5.284 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.76 APE8-dihe-in -79.73, 83.74 APE8-rot-na 34.28 APE67-dihe-in -52.0, -45.23 -70.34, -44.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.766 T790M,C797S None None XRAY 3.404 0.189 0.256 B 330 304 7 0 0 7 [[712, 970]] 1.0 8h7x Homo sapiens TYR_EGFR_HUMAN TYR 6.2e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5XGNB P00533 697 1019 1210.0 No_ligand No_ligand Inactive DFGinter 8.875 4.226 None -66.63, 139.03 -107.84, 34.93 -81.79, 142.31 255.34, 148.71 68.34, 31.51 in-in in 7.665 Saltbr-in 3.035 HRD-in -69.88, -38.92 70.25, -6.15 in-out-out SNCioo out-out ActLoopNT-out 5.544 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 59.97, 52.07 APE9-dihe-in -79.54, 147.42 APE8-dihe-in -94.06, 88.44 APE8-rot-na 27.93 APE67-dihe-in -64.82, -35.28 -54.4, -44.67 APE12-dist-na 12.386 APE11-dist-na 15.391 APE10-dist-na 15.977 APE9-dist-in 7.966 T790M,C797S None None XRAY 3.0 0.222 0.251 B 331 308 5 0 0 4 [[712, 970]] 1.0 5xgn Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2JITB P00533 697 1018 1210.0 No_ligand No_ligand Inactive DFGinter 8.643 4.268 None -65.09, 133.17 -114.41, 36.11 -84.27, 149.81 251.72, 154.26 60.91, 22.91 in-in in 8.03 Saltbr-in 3.164 HRD-in -71.83, -62.45 88.36, -10.04 in-out-in SNCioi out-in ActLoopNT-out 4.332 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.87, 136.57 APE9-dihe-in -138.24, 154.81 APE8-dihe-in -91.0, 80.78 APE8-rot-na 356.06 APE67-dihe-in -73.95, 11.71 -56.2, -43.16 APE12-dist-na 15.983 APE11-dist-na 15.773 APE10-dist-na 15.968 APE9-dist-in 7.412 T790M None None XRAY 3.1 0.209 0.249 B 327 312 0 0 0 0 [[712, 970]] 1.0 2jit Homo sapiens TYR_EGFR_HUMAN TYR 8e-88 300.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2JIUB P00533 695 1004 1210.0 No_ligand No_ligand Inactive DFGinter 8.912 4.352 None -62.48, 140.76 -118.63, 55.68 -100.13, 143.92 258.8, 146.55 62.94, 28.63 in-in in 8.076 Saltbr-in 2.959 HRD-in -72.84, -64.99 94.58, -35.5 in-in-in SNCiii in-in ActLoopNT-in 3.489 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.69, 118.33 APE9-dihe-in -133.73, 161.67 APE8-dihe-in -92.78, 73.55 APE8-rot-na 15.24 APE67-dihe-in -66.9, -25.87 -50.11, -38.12 APE12-dist-na 16.383 APE11-dist-na 15.152 APE10-dist-na 16.405 APE9-dist-in 7.624 T790M None None XRAY 3.05 0.214 0.277 B 328 310 0 0 0 0 [[712, 970]] 1.0 2jiu Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4G5PB P00533 697 1018 1210.0 No_ligand No_ligand Inactive DFGinter 8.694 4.058 None -102.27, 130.04 -119.39, 11.63 -56.23, 139.55 268.64, 132.98 83.16, 48.09 in-in in 7.531 Saltbr-in 2.909 HRD-in -73.51, -36.65 75.01, -67.24 in-out-out SNCioo out-out ActLoopNT-out 5.511 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 136.61 APE9-dihe-in -136.04, 152.17 APE8-dihe-in -101.09, 85.15 APE8-rot-na 34.16 APE67-dihe-in -61.97, -21.6 -60.83, -40.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 16.343 APE9-dist-out 8.971 T790M None None XRAY 3.17 0.247 0.323 B 330 303 8 0 0 8 [[712, 970]] 1.0 4g5p Homo sapiens TYR_EGFR_HUMAN TYR 8.3e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 3IKAB P00533 697 1017 1210.0 No_ligand No_ligand Inactive DFGinter 8.717 4.604 None -75.22, 143.75 -113.63, 39.19 -87.68, 145.68 264.7, 149.87 65.59, 19.15 in-in in 7.748 Saltbr-in 2.721 HRD-in -71.43, -56.54 82.98, -12.02 in-out-in SNCioi out-in ActLoopNT-out 5.388 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.44, 137.59 APE9-dihe-in -139.25, 153.6 APE8-dihe-in -85.59, 76.58 APE8-rot-na 26.0 APE67-dihe-in -74.82, -10.46 -52.9, -35.6 APE12-dist-na 16.909 APE11-dist-na 15.822 APE10-dist-na 16.726 APE9-dist-in 7.764 T790M None None XRAY 2.9 0.21 0.257 B 331 310 2 0 0 2 [[712, 970]] 1.0 3ika Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4WD5B P00533 697 1016 1210.0 No_ligand No_ligand Inactive DFGinter 9.248 4.425 None -72.57, 139.36 -100.73, 10.04 -62.48, 143.44 260.7, 137.62 58.63, 39.1 in-out in 7.729 Saltbr-out 3.739 HRD-out -90.94, 114.01 -64.78, -40.5 out-out-out SNCooo out-out ActLoopNT-out 4.978 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -60.44, 137.91 APE9-dihe-in -137.14, 159.08 APE8-dihe-in -84.32, 85.1 APE8-rot-na 36.97 APE67-dihe-in -61.6, -40.36 -63.96, -40.18 APE12-dist-na 16.585 APE11-dist-na 15.83 APE10-dist-na 16.945 APE9-dist-out 8.836 T790M None None XRAY 3.3 0.211 0.239 B 331 304 5 0 0 5 [[712, 970]] 1.0 4wd5 Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5UWDA P00533 702 984 1210.0 8OV:9001 Type1 Inactive DFGinter 8.718 6.883 None -103.03, 102.14 -79.54, 67.3 -112.01, -2.59 296.52, 123.95 -53.45, -42.68 out-out out 12.173 Saltbr-out 13.169 HRD-in -62.38, -44.86 62.12, -14.75 out-out-out SNCooo out-out ActLoopNT-out 9.302 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 33.47 APE9-dihe-in -110.69, 126.69 APE8-dihe-in -92.9, 52.09 APE8-rot-na 21.1 APE67-dihe-in -67.65, -3.97 -43.65, -47.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.321 APE9-dist-out 9.235 T790M,L858R,V948R None None XRAY 3.06 0.216 0.28 A 329 271 12 0 0 12 [[712, 970]] 1.0 5uwd Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2RF9A P00533 699 983 1210.0 No_ligand No_ligand Inactive DFGout 13.946 6.908 BBAminus -121.77, 171.61 -138.84, 149.59 -128.18, 33.73 287.89, 52.24 57.49, 26.72 out-none out 11.966 Saltbr-none 999.0 HRD-in -57.96, -48.51 81.96, -56.62 none-in-out SNCnio in-out ActLoopNT-in 3.15 ActLoopCT-out TYR APEdihe_ooiai APEdist_aaai APE10-dihe-out 170.52, -17.42 APE9-dihe-out 56.97, 109.88 APE8-dihe-in -40.66, 127.28 APE8-rot-na 329.03 APE67-dihe-in -45.77, -18.55 -54.08, -53.0 APE12-dist-na 999.0 APE11-dist-na 8.375 APE10-dist-na 10.766 APE9-dist-in 6.542 None None None XRAY 3.5 0.272 0.329 A 330 280 5 0 0 2 [[712, 970]] 1.0 2rf9 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4ZJVA P00533 703 985 1210.0 No_ligand No_ligand Inactive DFGout 13.648 7.793 BBAminus -127.0, 171.58 -126.44, 148.68 -117.71, 34.52 301.49, 64.95 92.13, 1.64 out-out out 12.571 Saltbr-out 8.618 HRD-in -71.09, -45.98 69.32, 4.23 out-in-in SNCoii in-in ActLoopNT-in 2.807 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.99, 123.56 APE9-dihe-in -138.04, 139.86 APE8-dihe-in -81.95, 80.42 APE8-rot-na 33.11 APE67-dihe-in -74.68, -3.27 -50.68, -46.13 APE12-dist-na 12.202 APE11-dist-na 10.543 APE10-dist-na 10.977 APE9-dist-in 7.492 None None None XRAY 2.7 0.181 0.232 A 331 282 1 0 0 0 [[712, 970]] 1.0 4zjv Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4ZJVB P00533 703 982 1210.0 No_ligand No_ligand Inactive DFGout 13.523 7.892 BBAminus -124.84, -179.31 -140.7, 141.17 -113.98, 39.53 310.83, 71.28 73.86, 21.11 out-out out 12.731 Saltbr-out 9.268 HRD-in -65.16, -49.82 70.39, 1.35 out-in-in SNCoii in-in ActLoopNT-in 3.01 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.29, 131.48 APE9-dihe-in -146.27, 149.66 APE8-dihe-in -85.36, 88.82 APE8-rot-na 34.04 APE67-dihe-in -73.12, -6.68 -56.73, -47.09 APE12-dist-na 13.048 APE11-dist-na 11.237 APE10-dist-na 11.34 APE9-dist-in 7.21 None None None XRAY 2.7 0.181 0.232 B 331 273 7 0 0 0 [[712, 970]] 1.0 4zjv Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5HG5A P00533 700 1001 1210.0 633:9001 Type1 Inactive DFGout 14.803 8.364 BBAminus -123.7, 162.96 -128.37, 131.07 -111.5, 16.12 283.55, 100.99 125.19, -6.98 out-out out 13.42 Saltbr-out 11.009 HRD-in -75.53, -48.64 74.12, 0.13 out-in-in SNCoii in-in ActLoopNT-in 2.869 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.29, 133.37 APE9-dihe-in -135.03, 151.84 APE8-dihe-in -78.84, 71.68 APE8-rot-na 29.34 APE67-dihe-in -76.12, -5.73 -47.63, -43.25 APE12-dist-na 12.595 APE11-dist-na 11.415 APE10-dist-na 11.449 APE9-dist-in 7.118 T790M,L858R,V948R None None XRAY 1.52 0.206 0.224 A 329 302 0 0 0 0 [[712, 970]] 1.0 5hg5 Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5HG7A P00533 702 984 1210.0 630:9001 Type1 Inactive DFGout 14.326 8.337 BBAminus -132.67, 173.3 -137.69, 131.94 -112.36, 18.94 289.01, 99.14 120.48, -2.68 out-out out 13.337 Saltbr-out 9.744 HRD-in -74.38, -53.22 72.9, 3.74 out-in-in SNCoii in-in ActLoopNT-in 2.873 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.6, 144.48 APE9-dihe-in -123.53, 137.72 APE8-dihe-in -77.18, 77.49 APE8-rot-na 29.41 APE67-dihe-in -75.59, -6.28 -49.29, -43.46 APE12-dist-na 11.737 APE11-dist-na 8.689 APE10-dist-na 10.085 APE9-dist-in 6.782 T790M,L858R,V948R None None XRAY 1.85 0.216 0.246 A 329 280 3 0 0 0 [[712, 970]] 1.0 5hg7 Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5HG8A P00533 700 999 1210.0 634:9001 Type1 Inactive DFGout 14.824 8.42 BBAminus -120.04, 168.11 -134.21, 135.65 -116.21, 20.34 285.7, 99.23 125.69, -13.05 out-out out 13.481 Saltbr-out 11.185 HRD-in -79.82, -49.01 72.91, 1.6 out-in-in SNCoii in-in ActLoopNT-in 2.847 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.09, 131.22 APE9-dihe-in -129.9, 151.08 APE8-dihe-in -78.57, 73.71 APE8-rot-na 29.52 APE67-dihe-in -75.55, -4.65 -50.28, -43.3 APE12-dist-na 12.521 APE11-dist-na 11.344 APE10-dist-na 11.296 APE9-dist-in 7.094 T790M,L858R,V948R None None XRAY 1.42 0.208 0.213 A 329 300 0 0 0 0 [[712, 970]] 1.0 5hg8 Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5HG9A P00533 702 985 1210.0 63A:9001 Type1 Inactive DFGout 14.39 8.031 BBAminus -124.48, 175.19 -143.23, 132.24 -115.31, 25.27 290.88, 96.34 118.56, -2.84 out-out out 13.425 Saltbr-out 10.805 HRD-in -76.66, -52.48 72.95, 0.75 out-in-in SNCoii in-in ActLoopNT-in 2.866 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.64, 144.64 APE9-dihe-in -126.99, 143.05 APE8-dihe-in -81.54, 85.2 APE8-rot-na 31.9 APE67-dihe-in -76.05, -4.9 -55.51, -39.71 APE12-dist-na 11.85 APE11-dist-na 8.667 APE10-dist-na 10.172 APE9-dist-in 6.721 T790M,L858R,V948R None None XRAY 2.15 0.191 0.241 A 329 280 4 0 0 0 [[712, 970]] 1.0 5hg9 Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5U8LA P00533 702 990 1210.0 O44:9001 Type1 Inactive DFGout 14.815 9.361 BBAminus -121.7, 139.9 -99.4, 120.55 -99.31, -4.66 285.11, 109.75 141.82, -0.88 out-out out 13.654 Saltbr-out 12.561 HRD-in -70.65, -49.86 74.9, -3.35 out-in-in SNCoii in-in ActLoopNT-in 2.847 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.83, 129.47 APE9-dihe-in -131.89, 148.97 APE8-dihe-in -77.16, 74.14 APE8-rot-na 29.74 APE67-dihe-in -76.4, -4.1 -48.81, -42.77 APE12-dist-na 12.182 APE11-dist-na 11.655 APE10-dist-na 11.463 APE9-dist-in 7.113 None None None XRAY 1.6 0.19 0.202 A 329 289 0 0 0 0 [[712, 970]] 1.0 5u8l Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5UG8A P00533 702 985 1210.0 8BP:9001 Type1 Inactive DFGout 14.154 8.218 BBAminus -136.95, 178.16 -138.97, 140.08 -122.37, 24.1 292.18, 96.54 126.49, -17.35 out-out out 13.261 Saltbr-out 10.787 HRD-in -79.51, -49.34 70.66, 4.02 out-in-in SNCoii in-in ActLoopNT-in 2.866 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.2, 139.83 APE9-dihe-in -119.57, 140.26 APE8-dihe-in -79.14, 75.66 APE8-rot-na 29.58 APE67-dihe-in -73.42, -6.5 -50.33, -43.3 APE12-dist-na 11.938 APE11-dist-na 8.839 APE10-dist-na 10.264 APE9-dist-in 6.861 T790M,L858R,V948R None None XRAY 1.46 0.193 0.207 A 329 280 4 0 0 0 [[712, 970]] 1.0 5ug8 Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5UG9A P00533 702 985 1210.0 8AM:9001 Type1 Inactive DFGout 14.257 8.207 BBAminus -137.56, 179.37 -140.87, 137.56 -120.13, 23.73 290.74, 97.27 126.22, -18.83 out-out out 13.293 Saltbr-out 10.693 HRD-in -78.33, -49.72 70.86, 4.97 out-in-in SNCoii in-in ActLoopNT-in 2.858 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.76, 138.99 APE9-dihe-in -120.58, 137.1 APE8-dihe-in -77.47, 74.07 APE8-rot-na 30.0 APE67-dihe-in -74.27, -6.2 -49.29, -43.04 APE12-dist-na 12.02 APE11-dist-na 8.895 APE10-dist-na 10.135 APE9-dist-in 6.864 T790M,L858R,V948R None None XRAY 1.33 0.195 0.205 A 329 280 4 0 0 0 [[712, 970]] 1.0 5ug9 Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5UGAA P00533 703 985 1210.0 8BM:9001 Type1 Inactive DFGout 14.653 8.259 BBAminus -135.66, 174.07 -125.55, 131.08 -113.25, 24.65 287.39, 110.13 125.08, -19.22 out-out out 13.276 Saltbr-out 10.633 HRD-in -79.29, -52.3 75.94, 2.9 out-in-in SNCoii in-in ActLoopNT-in 2.783 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.23, 135.61 APE9-dihe-in -132.36, 142.32 APE8-dihe-in -74.87, 80.04 APE8-rot-na 29.35 APE67-dihe-in -76.19, -4.88 -52.02, -42.4 APE12-dist-na 12.138 APE11-dist-na 10.954 APE10-dist-na 10.799 APE9-dist-in 7.005 T790M,L858R,V948R None None XRAY 1.82 0.235 0.264 A 329 283 0 0 0 0 [[712, 970]] 1.0 5uga Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5UGCA P00533 702 985 1210.0 8BS:9001 Type1 Inactive DFGout 14.396 8.262 BBAminus -131.19, 172.02 -138.19, 139.68 -122.92, 19.28 287.71, 102.44 122.8, -6.46 out-out out 13.418 Saltbr-out 10.829 HRD-in -75.41, -48.99 67.88, 4.79 out-in-in SNCoii in-in ActLoopNT-in 2.811 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.27, 140.43 APE9-dihe-in -121.9, 140.0 APE8-dihe-in -80.12, 76.64 APE8-rot-na 31.38 APE67-dihe-in -74.2, -5.62 -50.31, -42.01 APE12-dist-na 12.007 APE11-dist-na 8.905 APE10-dist-na 10.23 APE9-dist-in 6.881 T790M,L858R,V948R None None XRAY 1.58 0.201 0.223 A 329 280 4 0 0 0 [[712, 970]] 1.0 5ugc Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4I1ZA P00533 701 987 1210.0 No_ligand No_ligand Inactive DFGout 14.873 4.045 None -123.84, 156.94 -117.6, 154.19 -127.95, 41.9 206.23, 152.19 82.25, 13.26 out-out out 13.312 Saltbr-out 9.204 HRD-in -77.26, -39.87 64.35, 3.98 out-in-in SNCoii in-in ActLoopNT-in 2.872 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.73, 133.95 APE9-dihe-in -134.0, 149.51 APE8-dihe-in -74.99, 74.17 APE8-rot-na 30.04 APE67-dihe-in -83.17, 2.17 -68.31, -25.86 APE12-dist-na 13.037 APE11-dist-na 11.822 APE10-dist-na 11.398 APE9-dist-in 7.294 T790M,L858R,V948R None None XRAY 3.0 0.189 0.227 A 329 287 0 0 0 0 [[712, 970]] 1.0 4i1z Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4I21A P00533 703 1019 1210.0 No_ligand No_ligand Inactive DFGout 14.75 4.552 None -100.28, 172.71 -126.15, 170.08 -163.08, 33.14 210.49, 157.35 95.37, -18.48 out-out out 12.846 Saltbr-out 9.647 HRD-in -39.7, -18.75 35.21, 19.68 out-in-in SNCoii in-in ActLoopNT-in 2.866 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.28, 128.62 APE9-dihe-in -128.58, 144.56 APE8-dihe-in -73.89, 96.03 APE8-rot-na 28.14 APE67-dihe-in -80.61, -14.84 -75.13, -32.8 APE12-dist-na 12.13 APE11-dist-na 11.768 APE10-dist-na 11.247 APE9-dist-in 7.173 T790M,L858R None None XRAY 3.37 0.233 0.279 A 329 290 0 0 0 0 [[712, 970]] 1.0 4i21 Homo sapiens TYR_EGFR_HUMAN TYR 8.6e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4I21B P00533 703 1020 1210.0 No_ligand No_ligand Inactive DFGout 14.754 4.55 None -99.82, 173.29 -125.81, 171.27 -163.87, 32.69 210.88, 156.94 95.05, -18.24 out-out out 12.842 Saltbr-out 9.62 HRD-in -39.87, -18.86 36.39, 17.8 out-in-in SNCoii in-in ActLoopNT-in 2.825 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.87, 127.85 APE9-dihe-in -127.9, 144.31 APE8-dihe-in -73.55, 96.22 APE8-rot-na 28.09 APE67-dihe-in -81.62, -14.13 -75.34, -32.76 APE12-dist-na 12.135 APE11-dist-na 11.769 APE10-dist-na 11.247 APE9-dist-in 7.172 T790M,L858R None None XRAY 3.37 0.233 0.279 B 329 302 0 0 0 0 [[712, 970]] 1.0 4i21 Homo sapiens TYR_EGFR_HUMAN TYR 8.6e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2RF9B P00533 701 985 1210.0 No_ligand No_ligand Inactive DFGout 13.677 7.667 None -135.45, 135.37 -89.59, 173.5 -159.16, 36.83 280.02, 95.88 54.88, 39.47 out-none out 12.947 Saltbr-none 999.0 HRD-in -35.92, -46.42 73.77, -11.36 none-in-out SNCnio in-out ActLoopNT-in 3.076 ActLoopCT-out TYR APEdihe_ioiai APEdist_aaao APE10-dihe-in -82.18, 154.3 APE9-dihe-out -131.03, 36.1 APE8-dihe-in -91.14, 62.73 APE8-rot-na 345.67 APE67-dihe-in -51.39, -4.74 -69.87, -65.73 APE12-dist-na 999.0 APE11-dist-na 12.061 APE10-dist-na 8.253 APE9-dist-out 9.864 None None None XRAY 3.5 0.272 0.329 B 330 269 16 0 0 6 [[712, 970]] 1.0 2rf9 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4I20A P00533 701 987 1210.0 No_ligand No_ligand Inactive DFGout 15.068 4.091 None -125.7, 154.37 -115.95, 140.98 -109.44, 14.57 214.5, 120.81 110.72, -3.64 out-out out 13.214 Saltbr-out 10.498 HRD-in -72.27, -34.7 64.8, -22.69 out-in-in SNCoii in-in ActLoopNT-in 2.809 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.43, 132.98 APE9-dihe-in -132.7, 146.38 APE8-dihe-in -79.32, 93.47 APE8-rot-na 29.59 APE67-dihe-in -71.84, 11.17 -69.52, -44.48 APE12-dist-na 12.558 APE11-dist-na 10.986 APE10-dist-na 11.04 APE9-dist-in 7.592 L858R,V948R None None XRAY 3.34 0.202 0.242 A 329 287 0 0 0 0 [[712, 970]] 1.0 4i20 Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2ITNA P00533 696 1019 1210.0 ANP:2021 ATPlike None DFGin 6.283 15.235 BLAminus -127.19, -173.38 63.95, 79.84 -96.65, 10.56 295.4, 91.5 -73.87, 28.38 in-in in 8.274 Saltbr-in 3.408 HRD-in -81.37, -44.82 70.79, -0.2 in-in-none SNCiin in-none ActLoopNT-in 2.843 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 98.73 APE8-dihe-in -79.18, 91.37 APE8-rot-na 30.4 APE67-dihe-in -69.96, -4.57 -72.15, -41.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.674 G719S None None XRAY 2.47 0.201 0.267 A 327 304 9 0 0 9 [[712, 970]] 1.0 2itn Homo sapiens TYR_EGFR_HUMAN TYR 9.6e-87 296.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2ITVA P00533 696 1019 1210.0 ANP:2020 ATPlike None DFGin 6.216 15.481 BLAminus -132.41, -173.63 61.69, 81.35 -94.21, 13.19 293.51, 90.37 -58.84, 7.8 in-in in 8.584 Saltbr-in 3.462 HRD-in -75.87, -46.5 68.4, 1.6 in-in-none SNCiin in-none ActLoopNT-in 2.737 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.23 APE8-dihe-in -83.21, 92.63 APE8-rot-na 31.24 APE67-dihe-in -66.41, -6.91 -75.93, -39.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.569 L858R None None XRAY 2.47 0.197 0.242 A 327 303 9 0 0 9 [[712, 970]] 1.0 2itv Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5J9ZA P00533 696 1020 1210.0 6HJ:1101 Type1 None DFGin 6.232 15.757 BLAminus -138.58, -164.56 57.88, 71.43 -86.37, 17.12 309.51, 126.8 -45.81, -60.55 in-in in 8.649 Saltbr-in 2.954 HRD-in -68.38, -55.75 71.97, -7.78 in-in-none SNCiin in-none ActLoopNT-in 2.987 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 169.67 APE8-dihe-in -76.27, 71.14 APE8-rot-na 34.32 APE67-dihe-in -73.66, -10.96 -65.96, -35.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.794 T790M None None XRAY 2.5 0.198 0.239 A 325 291 15 0 0 15 [[712, 970]] 1.0 5j9z Homo sapiens TYR_EGFR_HUMAN TYR 7.9e-88 300.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6JX4A P00533 696 1018 1210.0 YY3:1101 Type1 None DFGin 6.538 15.295 BLAminus -153.26, -174.41 59.27, 71.1 -94.69, 11.38 288.28, 101.84 -61.51, -40.3 in-in in 8.089 Saltbr-in 3.167 HRD-in -72.1, -56.13 75.51, 1.81 in-in-none SNCiin in-none ActLoopNT-in 2.76 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 44.4 APE9-dihe-in -64.43, 143.52 APE8-dihe-in -93.62, 106.36 APE8-rot-na 34.75 APE67-dihe-in -65.07, -25.73 -81.11, -32.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.137 APE9-dist-in 7.793 T790M None None XRAY 2.531 0.213 0.245 A 331 315 8 0 0 8 [[712, 970]] 1.0 6jx4 Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7VRAA P00533 696 1018 1210.0 I0A:1101 Type1 None DFGin 6.329 14.98 BLAminus -141.39, -166.19 53.63, 67.86 -86.81, 26.91 290.4, 77.76 -61.4, -34.62 in-in in 8.262 Saltbr-in 2.7 HRD-in -73.36, -43.6 68.83, -12.22 in-in-none SNCiin in-none ActLoopNT-in 2.816 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 128.24 APE9-dihe-in -138.53, 146.25 APE8-dihe-in -81.73, 106.37 APE8-rot-na 16.59 APE67-dihe-in -71.3, -8.33 -70.5, -37.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.507 APE9-dist-in 6.955 T790M,C797S None None XRAY 2.41 0.221 0.245 A 331 289 15 0 0 11 [[712, 970]] 1.0 7vra Homo sapiens TYR_EGFR_HUMAN TYR 3.3e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7VREA P00533 696 1018 1210.0 7VH:1101 Type1 None DFGin 6.536 14.855 BLAminus -135.27, -171.61 56.81, 74.8 -92.4, 15.96 289.99, 73.74 -54.73, -16.72 in-in in 8.209 Saltbr-in 2.854 HRD-in -71.51, -50.16 76.97, -3.83 in-in-none SNCiin in-none ActLoopNT-in 2.785 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 43.94 APE9-dihe-in -79.86, 134.45 APE8-dihe-in -82.74, 99.99 APE8-rot-na 32.04 APE67-dihe-in -80.29, -2.71 -71.55, -29.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.336 APE9-dist-in 7.113 T790M,C797S None None XRAY 2.507 0.203 0.242 A 331 312 11 0 0 8 [[712, 970]] 1.0 7vre Homo sapiens TYR_EGFR_HUMAN TYR 3.3e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7ZYPA P00533 695 1019 1210.0 R25:1101 Type1 None DFGin 5.985 16.009 BLAminus -153.74, -167.87 58.65, 77.37 -99.18, 25.22 298.05, 95.24 -63.28, -21.65 in-none in 9.654 Saltbr-none 999.0 HRD-in -69.35, -50.87 70.3, 4.62 none-in-in SNCnii in-in ActLoopNT-in 2.922 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.66, 142.21 APE9-dihe-in -148.7, 155.05 APE8-dihe-in -93.0, 109.16 APE8-rot-na 20.15 APE67-dihe-in -64.26, -18.17 -75.15, -37.25 APE12-dist-na 11.405 APE11-dist-na 10.035 APE10-dist-na 10.094 APE9-dist-in 6.803 T790M,C797S,E865A,E866A,K867A None None XRAY 2.8 0.2 0.228 A 333 305 0 0 0 0 [[712, 970]] 1.0 7zyp Homo sapiens TYR_EGFR_HUMAN TYR 3.4e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9KLWA P00533 696 1019 1210.0 A1L53:61101 Type1 None DFGin 5.36 15.016 BLAminus -137.92, -173.21 68.95, 86.53 -103.04, 23.39 302.9, 100.52 -66.02, -20.59 in-in in 8.729 Saltbr-in 3.41 HRD-in -69.44, -47.22 66.72, 12.67 in-in-none SNCiin in-none ActLoopNT-in 2.938 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 149.08 APE8-dihe-in -82.92, 74.1 APE8-rot-na 34.98 APE67-dihe-in -75.3, -8.48 -60.53, -40.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.69 T790M,L858R None None XRAY 2.67 0.2 0.257 A 330 298 14 0 0 13 [[712, 970]] 1.0 9klw Homo sapiens TYR_EGFR_HUMAN TYR 8.6e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2ITYA P00533 697 1019 1210.0 IRE:2020 Type1 None DFGin 5.709 14.347 BLAminus -166.22, -170.95 51.79, 94.03 -111.38, 9.95 304.52, 88.76 -48.13, -2.84 in-in in 8.08 Saltbr-in 2.831 HRD-in -75.89, -42.81 70.47, -11.39 in-in-none SNCiin in-none ActLoopNT-in 2.641 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 109.72 APE8-dihe-in -87.66, 98.01 APE8-rot-na 34.48 APE67-dihe-in -68.44, -18.24 -69.59, -44.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.612 None None None XRAY 3.42 0.216 0.26 A 327 300 10 0 0 10 [[712, 970]] 1.0 2ity Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2J5FA P00533 696 1020 1210.0 DJK:3021 Type1 None DFGin 5.657 14.384 BLAminus -144.79, -170.55 64.0, 79.04 -97.73, 24.0 296.97, 99.2 -43.96, -47.9 in-in in 8.267 Saltbr-in 2.813 HRD-in -61.54, -44.58 69.15, -3.0 in-in-none SNCiin in-none ActLoopNT-in 2.636 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 173.56 APE9-dihe-in -112.83, 120.26 APE8-dihe-in -93.5, 101.2 APE8-rot-na 33.0 APE67-dihe-in -64.88, -16.77 -72.19, -43.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.227 APE9-dist-in 7.146 None None None XRAY 3.0 0.194 0.246 A 327 309 8 0 0 8 [[712, 970]] 1.0 2j5f Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6VHNA P00533 696 1019 1210.0 QQJ:1101 Type1 None DFGin 6.268 15.406 BLAminus -137.01, -168.66 62.81, 80.02 -103.64, 23.1 296.88, 98.97 -61.22, -32.89 in-in in 8.718 Saltbr-in 2.854 HRD-in -76.27, -52.37 76.32, -0.98 in-in-none SNCiin in-none ActLoopNT-in 2.981 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.2 APE8-dihe-in -87.73, 89.87 APE8-rot-na 30.35 APE67-dihe-in -72.35, -2.54 -65.87, -41.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.437 None None None XRAY 2.4 0.199 0.2 A 327 286 18 0 0 13 [[712, 970]] 1.0 6vhn Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6VHPA P00533 696 1019 1210.0 QP1:1101 Type1 None DFGin 6.015 15.357 BLAminus -142.26, -172.24 60.71, 82.75 -104.59, 30.45 301.25, 87.72 -60.33, -51.94 in-in in 8.978 Saltbr-in 2.908 HRD-in -76.89, -42.36 67.95, -9.7 in-in-none SNCiin in-none ActLoopNT-in 3.083 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 114.68 APE9-dihe-in -145.42, 154.51 APE8-dihe-in -84.79, 102.47 APE8-rot-na 20.66 APE67-dihe-in -73.32, -7.85 -65.47, -47.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.969 APE9-dist-in 6.918 None None None XRAY 3.6 0.184 0.218 A 327 308 5 0 0 5 [[712, 970]] 1.0 6vhp Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 8G63A P00533 696 1017 1210.0 YXT:1101 Type1 None DFGin 5.529 14.747 BLAminus -143.24, -159.19 52.58, 83.43 -103.22, 21.32 305.76, 90.64 -45.28, -71.59 in-in in 8.933 Saltbr-in 2.765 HRD-in -81.87, -48.78 71.13, -4.89 in-in-none SNCiin in-none ActLoopNT-in 2.615 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 172.53 APE8-dihe-in -91.35, 75.86 APE8-rot-na 29.34 APE67-dihe-in -73.76, 1.1 -57.31, -35.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.515 None None None XRAY 2.5 0.21 0.257 A 327 280 21 0 0 14 [[712, 970]] 1.0 8g63 Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9MSRA P00533 697 1017 1210.0 A1BRC:1101 Type1 None DFGin 5.713 14.487 BLAminus -136.25, -171.1 65.96, 74.47 -93.18, 22.16 295.01, 102.32 -70.66, -22.18 in-in in 8.313 Saltbr-in 2.678 HRD-in -75.31, -48.76 73.94, -5.89 in-in-none SNCiin in-none ActLoopNT-in 2.72 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 153.99 APE8-dihe-in -81.17, 80.82 APE8-rot-na 38.27 APE67-dihe-in -73.27, -2.94 -55.9, -44.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.248 None None None XRAY 1.93 0.199 0.231 A 327 277 23 0 0 13 [[712, 970]] 1.0 9msr Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9NHWA P00533 698 1017 1210.0 A1BYD:1101 Type1 None DFGin 6.053 15.233 BLAminus -144.87, -175.31 63.29, 77.05 -97.54, 24.54 296.32, 92.45 -60.8, -21.57 in-in in 8.651 Saltbr-in 2.717 HRD-in -72.16, -41.92 62.16, 7.57 in-in-none SNCiin in-none ActLoopNT-in 2.897 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.95 APE8-dihe-in -67.02, 107.82 APE8-rot-na 338.68 APE67-dihe-in -78.27, -0.53 -71.56, -34.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.576 None None None XRAY 2.73 0.239 0.268 A 327 280 18 0 0 8 [[712, 970]] 1.0 9nhw Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9NISA P00533 696 1016 1210.0 A1BYK:1101 Type1 None DFGin 6.187 15.633 BLAminus -132.6, -171.59 61.46, 82.06 -102.11, 30.13 293.65, 92.81 -70.22, -9.04 in-in in 8.824 Saltbr-in 2.777 HRD-in -74.0, -46.82 70.75, 2.25 in-in-none SNCiin in-none ActLoopNT-in 2.962 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 151.12 APE8-dihe-in -77.06, 100.01 APE8-rot-na 28.66 APE67-dihe-in -74.77, -0.45 -66.74, -40.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.61 None None None XRAY 2.23 0.235 0.262 A 327 281 17 0 0 10 [[712, 970]] 1.0 9nis Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9NJ7A P00533 698 1017 1210.0 A1BYL:1201 Type1 None DFGin 6.064 15.618 BLAminus -139.58, -169.66 55.85, 84.13 -103.94, 33.72 294.22, 89.03 -68.52, -21.81 in-in in 8.785 Saltbr-in 2.695 HRD-in -73.41, -43.75 67.32, 4.02 in-in-none SNCiin in-none ActLoopNT-in 2.833 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.66 APE8-dihe-in -73.6, 99.04 APE8-rot-na 28.02 APE67-dihe-in -69.1, -11.18 -63.58, -37.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.492 None None None XRAY 2.53 0.233 0.281 A 327 266 30 0 0 15 [[712, 970]] 1.0 9nj7 Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9NJNA P00533 698 1017 1210.0 A1BYS:1101 Type1 None DFGin 6.052 15.492 BLAminus -138.03, -171.71 61.23, 82.93 -102.84, 28.68 295.04, 92.18 -66.73, -16.96 in-in in 8.924 Saltbr-in 3.498 HRD-in -75.24, -45.9 66.95, 7.02 in-in-none SNCiin in-none ActLoopNT-in 2.929 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.33 APE8-dihe-in -71.72, 99.92 APE8-rot-na 26.75 APE67-dihe-in -76.44, 0.7 -63.78, -39.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.484 None None None XRAY 2.24 0.242 0.275 A 327 268 28 0 0 13 [[712, 970]] 1.0 9njn Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9NM0A P00533 697 1018 1210.0 VO7:1101 Type1 None DFGin 6.308 15.402 BLAminus -140.17, -167.49 58.79, 90.01 -111.11, 22.07 294.08, 94.65 -58.39, -24.66 in-in in 8.079 Saltbr-in 3.12 HRD-in -72.56, -49.62 74.29, -11.19 in-in-none SNCiin in-none ActLoopNT-in 2.75 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 98.9 APE8-rot-na 32.89 APE67-dihe-in -82.2, -4.65 -68.26, -37.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.59 0.209 0.247 A 327 273 27 0 0 16 [[712, 970]] 1.0 9nm0 Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9OS6A P00533 697 1017 1210.0 A1CEA:1101 Type1 None DFGin 5.787 14.723 BLAminus -149.68, -169.55 59.63, 82.89 -107.09, 37.79 302.53, 107.91 -67.77, -19.45 in-in in 8.65 Saltbr-in 2.864 HRD-in -73.22, -47.28 69.98, 3.7 in-in-none SNCiin in-none ActLoopNT-in 3.018 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.25 APE8-dihe-in -84.48, 84.59 APE8-rot-na 30.42 APE67-dihe-in -71.55, 6.59 -60.52, -46.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.437 None None None XRAY 2.75 0.211 0.255 A 327 277 22 0 0 14 [[712, 970]] 1.0 9os6 Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9OU9A P00533 697 1017 1210.0 A1CEL:1101 Type1 None DFGin 5.729 14.516 BLAminus -137.92, -166.98 64.48, 74.8 -101.38, 16.31 294.29, 103.58 -68.16, -2.57 in-in in 8.231 Saltbr-in 2.731 HRD-in -76.83, -48.14 74.88, -4.57 in-in-none SNCiin in-none ActLoopNT-in 2.996 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.04 APE8-dihe-in -78.65, 85.77 APE8-rot-na 33.59 APE67-dihe-in -75.11, -2.66 -60.42, -41.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.221 None None None XRAY 2.1 0.214 0.237 A 327 273 27 0 0 14 [[712, 970]] 1.0 9ou9 Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9PMZA P00533 696 1017 1210.0 A1CI6:1101 Type1 None DFGin 5.741 14.718 BLAminus -141.27, -164.81 54.84, 75.79 -92.43, 17.4 302.76, 94.3 -60.93, -6.56 in-in in 8.224 Saltbr-in 2.955 HRD-in -74.27, -47.37 73.88, -9.62 in-in-none SNCiin in-none ActLoopNT-in 2.719 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.7 APE8-dihe-in -72.89, 85.98 APE8-rot-na 29.14 APE67-dihe-in -69.79, -5.39 -61.94, -45.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.228 None None None XRAY 2.33 0.212 0.234 A 327 275 24 0 0 14 [[712, 970]] 1.0 9pmz Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9Q0SA P00533 696 1017 1210.0 A1CNG:1101 Type1 None DFGin 5.818 14.767 BLAminus -143.82, -165.71 57.17, 86.13 -105.9, 15.22 297.18, 94.28 -50.67, -31.29 in-in in 8.231 Saltbr-in 2.931 HRD-in -72.33, -50.59 70.45, -0.8 in-in-none SNCiin in-none ActLoopNT-in 2.875 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 137.72 APE9-dihe-in -139.48, 141.11 APE8-dihe-in -78.02, 96.92 APE8-rot-na 30.24 APE67-dihe-in -74.69, -0.83 -75.68, -39.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.841 APE9-dist-in 6.924 None None None XRAY 2.46 0.199 0.241 A 327 283 18 0 0 8 [[712, 970]] 1.0 9q0s Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7UKVA P00533 696 1018 1210.0 ZRT:1101 Type1 None DFGin 5.936 15.094 BLAminus -138.2, -168.81 62.37, 83.02 -103.85, 24.26 298.25, 88.25 -61.11, -23.87 in-in in 8.689 Saltbr-in 2.994 HRD-in -78.76, -49.38 70.66, 2.89 in-in-none SNCiin in-none ActLoopNT-in 2.973 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 127.73 APE9-dihe-in -144.8, 152.44 APE8-dihe-in -81.13, 94.3 APE8-rot-na 29.19 APE67-dihe-in -72.65, 4.24 -61.82, -42.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.234 APE9-dist-in 6.419 None None None XRAY 2.4 0.213 0.243 A 328 290 13 0 0 6 [[712, 970]] 1.0 7ukv Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4ZAUA P00533 698 1017 1210.0 YY3:1101 Type1 None DFGin 6.017 15.47 BLAminus -144.79, -170.19 56.78, 87.23 -105.06, 22.23 291.67, 100.52 -61.25, -22.95 in-in in 9.092 Saltbr-in 3.506 HRD-in -80.01, -54.39 75.7, 11.54 in-in-none SNCiin in-none ActLoopNT-in 2.891 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 172.16 APE9-dihe-in -149.48, 142.85 APE8-dihe-in -76.13, 94.93 APE8-rot-na 357.17 APE67-dihe-in -79.77, -9.04 -61.73, -40.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.194 APE9-dist-in 6.955 None None None XRAY 2.8 0.196 0.244 A 330 283 14 0 0 5 [[712, 970]] 1.0 4zau Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7U9AA P00533 695 1018 1210.0 M19:61101 Type1 None DFGin 5.969 14.939 BLAminus -138.43, -165.64 57.15, 83.56 -106.29, 27.74 295.81, 111.25 -65.3, -26.31 in-in in 8.739 Saltbr-in 2.631 HRD-in -72.31, -46.85 63.99, 11.01 in-in-none SNCiin in-none ActLoopNT-in 2.885 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 100.67 APE9-dihe-in -142.4, 152.93 APE8-dihe-in -83.85, 92.87 APE8-rot-na 27.47 APE67-dihe-in -72.2, -7.47 -60.15, -49.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.104 APE9-dist-in 6.686 None None None XRAY 2.6 0.196 0.226 A 331 294 9 0 0 4 [[712, 970]] 1.0 7u9a Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 7B85A P00533 697 1020 1210.0 R28:1101 Type1 None DFGin 5.854 14.557 BLAminus -137.84, -174.1 60.63, 85.07 -103.17, 26.09 294.86, 88.23 -63.8, -24.92 in-in in 7.92 Saltbr-in 2.748 HRD-in -73.34, -48.14 69.22, 2.13 in-in-none SNCiin in-none ActLoopNT-in 3.018 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 121.75 APE9-dihe-in -146.0, 163.38 APE8-dihe-in -89.43, 103.15 APE8-rot-na 22.0 APE67-dihe-in -71.22, -17.13 -66.77, -37.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.554 APE9-dist-in 6.798 None None None XRAY 2.5 0.216 0.244 A 333 312 6 0 0 2 [[712, 970]] 1.0 7b85 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2ITOA P00533 696 1019 1210.0 IRE:2020 Type1 None DFGin 5.748 14.141 BLAminus -140.08, -168.63 58.3, 91.81 -104.54, 8.97 300.44, 102.41 -49.01, 0.84 in-in in 7.815 Saltbr-in 3.161 HRD-in -92.02, -52.4 73.42, 24.83 in-in-none SNCiin in-none ActLoopNT-in 2.691 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 104.39 APE8-dihe-in -85.12, 86.77 APE8-rot-na 30.96 APE67-dihe-in -73.18, -3.24 -69.84, -38.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.404 G719S None None XRAY 3.25 0.197 0.266 A 327 303 9 0 0 9 [[712, 970]] 1.0 2ito Homo sapiens TYR_EGFR_HUMAN TYR 9.6e-87 296.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6S9BA P00533 697 1019 1210.0 L1H:1101 Type1 None DFGin 6.118 15.018 BLAminus -148.24, -172.87 65.26, 88.24 -111.59, 23.4 302.91, 91.25 -69.84, -29.04 in-in in 8.68 Saltbr-in 2.766 HRD-in -77.95, -44.62 67.36, 12.41 in-in-none SNCiin in-none ActLoopNT-in 2.789 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 130.6 APE9-dihe-in -136.99, 149.82 APE8-dihe-in -88.88, 86.38 APE8-rot-na 33.73 APE67-dihe-in -72.04, -14.11 -61.18, -35.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.083 APE9-dist-in 7.2 T790M,L858R,E865A,E866A,K867A None None XRAY 3.25 0.186 0.232 A 326 291 15 0 0 12 [[712, 970]] 1.0 6s9b Homo sapiens TYR_EGFR_HUMAN TYR 4.4e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6S9CA P00533 696 1019 1210.0 L1K:61101 Type1 None DFGin 5.825 14.722 BLAminus -137.24, -177.45 69.22, 83.47 -102.5, 27.64 296.66, 90.76 -71.56, -8.94 in-in in 8.526 Saltbr-in 2.833 HRD-in -60.53, -44.79 71.19, 1.46 in-in-none SNCiin in-none ActLoopNT-in 2.756 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 105.07 APE9-dihe-in -124.15, 154.71 APE8-dihe-in -82.6, 76.59 APE8-rot-na 34.11 APE67-dihe-in -73.9, -13.53 -58.44, -39.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.508 APE9-dist-in 7.756 T790M,L858R,E865A,E866A,K867A None None XRAY 2.73 0.202 0.225 A 329 299 14 0 0 12 [[712, 970]] 1.0 6s9c Homo sapiens TYR_EGFR_HUMAN TYR 4.5e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4RJ4A P00533 697 1018 1210.0 3QW:1101 Type1 None DFGin 5.642 14.869 BLAminus -140.69, -172.61 68.51, 86.31 -99.76, 22.2 296.02, 102.47 -65.67, -16.31 in-in in 8.584 Saltbr-in 2.803 HRD-in -56.37, -48.84 66.69, -1.93 in-in-none SNCiin in-none ActLoopNT-in 2.843 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.29 APE8-dihe-in -86.76, 81.28 APE8-rot-na 21.53 APE67-dihe-in -69.94, -5.61 -53.89, -50.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.202 T790M,L858R,E865A,E866A,K867A None None XRAY 2.78 0.19 0.226 A 331 299 17 0 0 14 [[712, 970]] 1.0 4rj4 Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4RJ7A P00533 697 1018 1210.0 3R1:1102 Type1 None DFGin 6.017 14.69 BLAminus -136.51, -172.32 66.59, 81.87 -97.51, 17.72 294.15, 102.13 -65.84, -16.96 in-in in 8.348 Saltbr-in 3.238 HRD-in -60.19, -50.96 69.31, -0.58 in-in-none SNCiin in-none ActLoopNT-in 2.741 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.16 APE8-dihe-in -78.25, 70.95 APE8-rot-na 29.95 APE67-dihe-in -67.71, -3.19 -45.43, -49.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.219 T790M,L858R,E865A,E866A,K867A None None XRAY 2.55 0.207 0.234 A 331 295 19 0 0 14 [[712, 970]] 1.0 4rj7 Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4RJ8A P00533 697 1018 1210.0 3QS:1102 Type1 None DFGin 5.739 14.839 BLAminus -139.18, -167.47 68.29, 77.56 -89.12, 10.26 294.1, 106.72 -54.86, -20.91 in-in in 8.396 Saltbr-in 2.794 HRD-in -60.49, -55.01 73.42, -2.13 in-in-none SNCiin in-none ActLoopNT-in 2.781 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.62 APE8-dihe-in -86.58, 81.4 APE8-rot-na 26.4 APE67-dihe-in -68.07, -3.17 -48.59, -54.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.12 T790M,L858R,E865A,E866A,K867A None None XRAY 2.5 0.197 0.226 A 331 298 18 0 0 14 [[712, 970]] 1.0 4rj8 Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5C8KA P00533 697 1018 1210.0 4YV:1101 Type1 None DFGin 5.618 14.865 BLAminus -142.56, -168.74 65.75, 82.14 -97.63, 22.27 300.75, 101.92 -60.4, -26.09 in-in in 8.741 Saltbr-in 2.765 HRD-in -67.41, -39.79 60.89, -7.73 in-in-none SNCiin in-none ActLoopNT-in 2.986 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.8 APE8-dihe-in -95.26, 73.85 APE8-rot-na 27.78 APE67-dihe-in -64.32, -5.28 -41.93, -56.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.159 T790M,L858R,E865A,E866A,K867A None None XRAY 3.0 0.202 0.251 A 331 300 17 0 0 15 [[712, 970]] 1.0 5c8k Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5C8MA P00533 697 1019 1210.0 4YW:1101 Type1 None DFGin 6.03 15.137 BLAminus -139.93, -166.43 62.51, 82.79 -104.18, 35.15 303.24, 104.63 -71.47, -7.58 in-in in 8.656 Saltbr-in 2.802 HRD-in -63.0, -55.16 74.91, -5.77 in-in-none SNCiin in-none ActLoopNT-in 3.092 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.92 APE8-dihe-in -91.72, 83.46 APE8-rot-na 23.85 APE67-dihe-in -63.98, -6.63 -55.14, -47.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.308 T790M,L858R,E865A,E866A,K867A None None XRAY 2.9 0.21 0.252 A 331 302 16 0 0 14 [[712, 970]] 1.0 5c8m Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5C8NA P00533 696 1019 1210.0 4YX:1102 Type1 None DFGin 5.55 14.849 BLAminus -130.09, -164.08 61.96, 83.03 -95.79, 18.7 301.11, 101.32 -62.83, -10.09 in-in in 8.554 Saltbr-in 2.837 HRD-in -74.54, -49.37 73.34, -0.43 in-in-none SNCiin in-none ActLoopNT-in 2.861 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.63 APE8-dihe-in -90.67, 83.94 APE8-rot-na 35.45 APE67-dihe-in -71.85, 0.66 -67.76, -45.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.237 T790M,L858R,E865A,E866A,K867A None None XRAY 2.401 0.204 0.258 A 331 300 17 0 0 14 [[712, 970]] 1.0 5c8n Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5CALA P00533 697 1018 1210.0 4Z8:1101 Type1 None DFGin 5.497 14.495 BLAminus -137.41, -172.89 65.78, 89.63 -103.26, 18.8 297.84, 103.35 -65.07, -18.88 in-in in 8.735 Saltbr-in 2.949 HRD-in -63.06, -53.55 70.57, -1.46 in-in-none SNCiin in-none ActLoopNT-in 3.026 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.13 APE8-dihe-in -87.57, 76.27 APE8-rot-na 28.21 APE67-dihe-in -69.94, -3.46 -48.77, -46.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.071 T790M,L858R,E865A,E866A,K867A None None XRAY 2.7 0.206 0.227 A 331 300 17 0 0 15 [[712, 970]] 1.0 5cal Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5CANA P00533 696 1019 1210.0 4ZB:1102 Type1 None DFGin 5.619 14.735 BLAminus -142.73, -174.9 68.91, 93.29 -106.76, 21.14 296.79, 103.43 -65.99, -14.88 in-in in 8.569 Saltbr-in 2.838 HRD-in -62.3, -49.88 68.9, -1.6 in-in-none SNCiin in-none ActLoopNT-in 2.799 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.26 APE8-dihe-in -87.26, 78.01 APE8-rot-na 20.78 APE67-dihe-in -67.65, -1.03 -49.32, -53.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.199 T790M,L858R,E865A,E866A,K867A None None XRAY 2.8 0.198 0.232 A 331 301 16 0 0 14 [[712, 970]] 1.0 5can Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5CAOA P00533 697 1019 1210.0 4ZG:1101 Type1 None DFGin 5.726 14.535 BLAminus -132.0, -172.67 65.56, 80.31 -104.95, 26.76 323.84, 105.62 -77.97, 14.2 in-in in 8.772 Saltbr-in 3.033 HRD-in -58.9, -58.41 76.18, -10.46 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.94 APE8-dihe-in -90.41, 73.41 APE8-rot-na 26.26 APE67-dihe-in -60.83, -6.66 -44.66, -55.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.42 T790M,L858R,E865A,E866A,K867A None None XRAY 2.6 0.203 0.231 A 331 300 19 0 0 16 [[712, 970]] 1.0 5cao Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5CAPA P00533 697 1019 1210.0 4ZH:1103 Type1 None DFGin 5.965 15.081 BLAminus -134.45, -171.01 71.99, 88.37 -110.44, 24.81 303.88, 121.07 -72.28, -6.86 in-in in 8.389 Saltbr-in 2.786 HRD-in -63.56, -57.8 76.6, -10.03 in-in-none SNCiin in-none ActLoopNT-in 3.14 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.82 APE8-dihe-in -83.94, 76.0 APE8-rot-na 26.21 APE67-dihe-in -67.04, -0.42 -50.69, -48.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.483 T790M,L858R,E865A,E866A,K867A None None XRAY 2.4 0.191 0.213 A 331 303 15 0 0 15 [[712, 970]] 1.0 5cap Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5EM7A P00533 696 1019 1210.0 5Q4:1102 Type1 None DFGin 6.063 14.737 BLAminus -135.51, -175.43 63.24, 90.16 -107.26, 25.15 291.83, 97.24 -73.87, -13.09 in-in in 8.193 Saltbr-in 2.807 HRD-in -60.94, -47.98 66.46, -2.63 in-in-none SNCiin in-none ActLoopNT-in 2.774 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.59 APE8-dihe-in -87.95, 81.76 APE8-rot-na 24.14 APE67-dihe-in -66.12, -4.01 -54.22, -49.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.23 T790M,L858R,E865A,E866A,K867A None None XRAY 2.81 0.19 0.216 A 331 300 17 0 0 14 [[712, 970]] 1.0 5em7 Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5HCXA P00533 696 1018 1210.0 60B:1102 Type1 None DFGin 5.679 14.34 BLAminus -134.75, -168.37 67.26, 84.11 -97.03, 11.58 292.78, 109.41 -56.16, -12.04 in-in in 8.197 Saltbr-in 3.182 HRD-in -55.82, -53.35 72.1, 1.2 in-in-none SNCiin in-none ActLoopNT-in 2.777 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.91 APE8-dihe-in -89.45, 69.04 APE8-rot-na 28.83 APE67-dihe-in -67.35, -11.16 -46.21, -47.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.3 T790M,L858R,E865A,E866A,K867A None None XRAY 2.6 0.194 0.223 A 331 298 17 0 0 14 [[712, 970]] 1.0 5hcx Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5HCZA P00533 696 1019 1210.0 60E:1102 Type1 None DFGin 5.51 14.126 BLAminus -138.48, -168.94 67.59, 84.64 -98.68, 22.07 297.97, 107.23 -59.74, -32.24 in-in in 8.208 Saltbr-in 2.979 HRD-in -55.25, -49.19 68.73, 4.6 in-in-none SNCiin in-none ActLoopNT-in 2.777 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.77 APE8-dihe-in -87.19, 65.54 APE8-rot-na 27.65 APE67-dihe-in -64.96, -12.37 -40.06, -51.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.324 T790M,L858R,E865A,E866A,K867A None None XRAY 2.62 0.196 0.227 A 331 300 17 0 0 14 [[712, 970]] 1.0 5hcz Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 2ITTA P00533 697 1019 1210.0 AEE:2020 Type1 None DFGin 5.936 14.965 BLAminus -130.73, -162.83 54.09, 78.3 -90.96, 8.6 295.86, 89.36 -44.57, 3.1 in-in in 8.368 Saltbr-in 2.867 HRD-in -70.65, -43.73 65.16, 6.34 in-in-none SNCiin in-none ActLoopNT-in 2.821 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.78 APE8-dihe-in -88.12, 98.9 APE8-rot-na 27.6 APE67-dihe-in -72.01, -6.18 -71.82, -40.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.493 L858R None None XRAY 2.73 0.212 0.262 A 327 302 9 0 0 9 [[712, 970]] 1.0 2itt Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5X26A P00533 697 1020 1210.0 7XO:1101 Type1 None DFGin 6.188 14.935 BLAminus -153.57, -170.14 58.63, 70.59 -94.54, 18.38 292.51, 110.93 -60.72, -39.59 in-in in 8.548 Saltbr-in 3.317 HRD-in -64.24, -45.47 69.82, 6.31 in-in-none SNCiin in-none ActLoopNT-in 2.835 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.99 APE8-dihe-in -94.19, 95.15 APE8-rot-na 32.94 APE67-dihe-in -63.12, -36.92 -65.94, -42.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.448 L858R None None XRAY 2.951 0.197 0.222 A 327 302 9 0 0 9 [[712, 970]] 1.0 5x26 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5X27A P00533 697 1020 1210.0 7XR:1101 Type1 None DFGin 6.089 14.567 BLAminus -142.52, -171.15 59.08, 68.89 -91.56, 16.87 296.22, 103.35 -59.61, -40.88 in-in in 8.476 Saltbr-in 3.407 HRD-in -67.74, -41.55 62.13, 9.32 in-in-none SNCiin in-none ActLoopNT-in 2.795 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.75 APE8-dihe-in -94.41, 99.92 APE8-rot-na 33.71 APE67-dihe-in -62.5, -41.39 -64.95, -42.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.156 L858R None None XRAY 2.952 0.205 0.238 A 327 302 9 0 0 9 [[712, 970]] 1.0 5x27 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5X28A P00533 697 1020 1210.0 7XU:1101 Type1 None DFGin 6.242 14.981 BLAminus -155.25, -168.54 56.92, 67.25 -92.6, 16.38 291.1, 113.77 -60.0, -38.56 in-in in 8.766 Saltbr-in 2.872 HRD-in -64.09, -44.41 72.37, 3.05 in-in-none SNCiin in-none ActLoopNT-in 2.907 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.7 APE8-dihe-in -90.21, 91.04 APE8-rot-na 33.64 APE67-dihe-in -63.4, -43.04 -64.77, -43.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.502 L858R None None XRAY 2.952 0.211 0.25 A 327 310 9 0 0 9 [[712, 970]] 1.0 5x28 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5XDLA P00533 696 1018 1210.0 8JC:1101 Type1 None DFGin 6.15 14.871 BLAminus -146.3, -172.59 64.93, 71.28 -94.1, 9.83 302.09, 99.18 -52.93, -42.05 in-in in 8.394 Saltbr-in 3.228 HRD-in -74.03, -53.77 76.73, 1.67 in-in-none SNCiin in-none ActLoopNT-in 3.156 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 59.31 APE8-rot-na 32.98 APE67-dihe-in -74.19, -13.64 -84.48, -30.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 L858R None None XRAY 2.7 0.212 0.256 A 331 292 17 0 0 15 [[712, 970]] 1.0 5xdl Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 9U8CD P00533 696 987 1210.0 A1L8T:61101 Type1 None DFGin 5.518 14.842 BLAminus -152.89, -164.88 57.37, 59.02 -76.65, 17.66 286.7, 98.09 -55.38, -41.88 in-in in 8.871 Saltbr-in 3.187 HRD-in -114.09, -29.54 63.53, -55.66 in-in-none SNCiin in-none ActLoopNT-in 3.462 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.4 APE8-dihe-in -82.7, 101.15 APE8-rot-na 29.1 APE67-dihe-in -63.15, -43.97 -69.62, -36.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.518 None None None XRAY 3.5 0.275 0.3 D 338 285 7 0 0 4 [[712, 970]] 1.0 9u8c Homo sapiens TYR_EGFR_HUMAN TYR 1.7e-85 292.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 6D8EA P00533 696 1019 1210.0 FZP:1101 Type1.5_Back None DFGin 6.042 15.059 BLAminus -138.11, -172.24 64.79, 63.43 -86.6, 14.58 312.63, 81.25 -43.94, -59.79 in-in in 8.652 Saltbr-in 2.645 HRD-in -72.15, -45.77 63.05, 4.69 in-in-none SNCiin in-none ActLoopNT-in 3.016 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 112.81 APE9-dihe-in -139.79, 164.58 APE8-dihe-in -99.25, 105.5 APE8-rot-na 28.33 APE67-dihe-in -68.5, -6.69 -82.32, -41.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.866 APE9-dist-in 7.175 None None None XRAY 2.537 0.212 0.243 A 327 304 9 0 0 5 [[712, 970]] 1.0 6d8e Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 4RJ5A P00533 697 1019 1210.0 3QY:1101 Type1.5_Back None DFGin 6.144 15.305 BLAminus -139.13, -172.0 64.67, 84.34 -102.51, 37.37 294.94, 103.28 -69.92, -22.45 in-in in 8.602 Saltbr-in 2.803 HRD-in -64.72, -40.04 62.76, -16.92 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.1 APE8-dihe-in -84.86, 78.78 APE8-rot-na 27.08 APE67-dihe-in -69.19, -9.72 -53.68, -42.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.385 T790M,L858R,E865A,E866A,K867A None None XRAY 3.1 0.195 0.229 A 331 296 20 0 0 16 [[712, 970]] 1.0 4rj5 Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5CAQA P00533 697 1018 1210.0 4ZJ:1102 Type1.5_Back None DFGin 5.668 14.915 BLAminus -137.02, -170.07 67.33, 79.05 -91.72, 13.18 294.21, 102.26 -60.56, -10.03 in-in in 8.672 Saltbr-in 2.802 HRD-in -60.07, -52.9 72.53, 1.36 in-in-none SNCiin in-none ActLoopNT-in 2.794 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.08 APE8-dihe-in -79.35, 76.04 APE8-rot-na 30.69 APE67-dihe-in -65.52, -10.47 -45.15, -52.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.989 T790M,L858R,E865A,E866A,K867A None None XRAY 2.5 0.185 0.224 A 331 301 16 0 0 14 [[712, 970]] 1.0 5caq Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5CASA P00533 696 1019 1210.0 4ZQ:1102 Type1.5_Back None DFGin 5.648 14.99 BLAminus -138.57, -167.77 68.04, 80.06 -91.6, 15.8 296.16, 107.26 -57.65, -21.97 in-in in 8.912 Saltbr-in 2.832 HRD-in -67.55, -52.18 71.84, 1.99 in-in-none SNCiin in-none ActLoopNT-in 2.788 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.6 APE8-dihe-in -82.22, 70.93 APE8-rot-na 30.15 APE67-dihe-in -66.03, -7.47 -43.73, -55.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.053 T790M,L858R,E865A,E866A,K867A None None XRAY 2.1 0.184 0.209 A 331 299 17 0 0 13 [[712, 970]] 1.0 5cas Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5CAUA P00533 696 1018 1210.0 4ZR:1102 Type1.5_Back None DFGin 5.613 14.906 BLAminus -141.53, -166.31 67.78, 77.4 -89.35, 12.82 295.09, 107.73 -56.63, -14.57 in-in in 8.802 Saltbr-in 2.786 HRD-in -63.68, -54.38 71.77, 1.7 in-in-none SNCiin in-none ActLoopNT-in 2.815 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.07 APE8-dihe-in -84.23, 76.34 APE8-rot-na 31.68 APE67-dihe-in -64.39, -7.38 -48.76, -54.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.158 T790M,L858R,E865A,E866A,K867A None None XRAY 2.25 0.188 0.211 A 331 297 18 0 0 14 [[712, 970]] 1.0 5cau Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5HCYA P00533 696 1019 1210.0 60D:1102 Type1.5_Back None DFGin 5.564 14.343 BLAminus -135.17, -165.75 65.93, 78.25 -91.02, 13.27 295.4, 107.72 -55.11, -21.47 in-in in 8.422 Saltbr-in 2.796 HRD-in -60.52, -51.07 73.09, 1.44 in-in-none SNCiin in-none ActLoopNT-in 2.793 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.03 APE8-dihe-in -85.54, 71.02 APE8-rot-na 32.48 APE67-dihe-in -70.08, -5.63 -50.19, -42.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.509 T790M,L858R,E865A,E866A,K867A None None XRAY 2.46 0.178 0.221 A 331 302 15 0 0 13 [[712, 970]] 1.0 5hcy Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
EGFR_HUMAN 5HICA P00533 697 1019 1210.0 63N:1102 Type1.5_Back None DFGin 5.647 14.297 BLAminus -139.13, -164.08 62.52, 78.14 -92.5, 16.36 295.34, 105.72 -61.37, -14.82 in-in in 8.313 Saltbr-in 3.06 HRD-in -60.28, -47.26 67.03, 5.82 in-in-none SNCiin in-none ActLoopNT-in 2.815 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.05 APE8-dihe-in -87.68, 72.67 APE8-rot-na 27.72 APE67-dihe-in -63.88, -10.28 -48.63, -51.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.353 T790M,L858R,E865A,E866A,K867A None None XRAY 2.6 0.191 0.233 A 331 302 16 0 0 14 [[712, 970]] 1.0 5hic Homo sapiens TYR_EGFR_HUMAN TYR 4.6e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

TYR_EGFR (Epidermal growth factor receptor)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name