8D76

EGFR (Epidermal growth factor receptor)
Group: TYR
Uniprot: EGFR_HUMAN
Organism: Homo sapiens
Domain boundary: 712 - 970
Resolu: 2.4

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in QFO Type1.5_Back 703 - 1014 0
B Active DFGin BLAminus in-in in-in QFO Type1.5_Back 702 - 1014 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
         -          -        704        714 
mgsshhhhhh ssgenlyfqg sgeapnqALL RILKETEFKK 
       724        734        744        754 
IKVLGSGAFG TVYKGLWIPE GEKVKIPVAI KELREATSPK 
       764        774        784        794 
ANKEILDEAY VMASVDNPHV CRLLGICLTS TVQLIMQLMP 
       804        814        824        834 
FGCLLDYVRE HKDNIGSQYL LNWCVQIAKG MNYLEDRRLV 
       844        854        864        874 
HRDLAARNVL VKTPQHVKIT DFGRAKLLGA EEKEYHAEGG 
       884        894        904        914 
KVPIKWMALE SILHRIYTHQ SDVWSYGVTV WELMTFGSKP 
       924        934        944        954 
YDGIPASEIS SILEKGERLP QPPICTIDVY MIMRKCWMID 
       964        974        984        994 
ADSRPKFREL IIEFSKMARD PQRYLVIQGD ERMHLPSPTD 
      1004       1014 
SNFYRALMDE EDMDDVVDAD eylipqqg
Lower-case residues are disordered in structure.
Mutations: T790M,L858R,V948R
Phosphorylation: None