TKL_BRAF (Serine/threonine-protein kinase B-raf)

Total number of chains: 218
Active chains: 4
Uniprot: BRAF_HUMAN
Kinase Domain Residues: 457 - 716
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 73 33.5% 8C7YA
DFGin BLAplus 41 18.8% 9BP8A
DFGin BLAminus 39 17.9% AF-P15056-K1A
DFGin BLBplus 20 9.2% 7M0XA
DFGin BLBminus 13 6.0% 7P3VB
None None 12 5.5% 6Q0JA
DFGin None 11 5.0% 4MBJB
DFGout None 7 3.2% 8QQGA
DFGin ABAminus 2 0.9% 4H58B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P15056-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 449 - 724 0 None None Serine/threonine-protein kinase B-raf
AF-P15056-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 449 - 724 0 None None Serine/threonine-protein kinase B-raf
4MNEC 2.848 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 449 - 720 0 None None Serine/threonine-protein kinase B-raf
4MNEF 2.848 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 449 - 721 0 None None Serine/threonine-protein kinase B-raf
4H58B 3.1 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaoii APEdist_nooo No_ligand No_ligand 448 - 722 0 None None Serine/threonine-protein kinase B-raf
3PRFA 2.9 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaioo APEdist_nnno FP3 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf
9AXXB 2.07 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 449 - 721 0 None None Serine/threonine-protein kinase B-raf
4XV1B 2.47 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aanii APEdist_nnnn No_ligand No_ligand 449 - 705 0 None S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R Serine/threonine-protein kinase B-raf
6XAGC 3.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 449 - 732 0 SEP729 None Serine/threonine-protein kinase B-raf
6XAGD 3.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nioo No_ligand No_ligand 448 - 733 0 SEP729 None Serine/threonine-protein kinase B-raf
9AXXD 2.07 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi No_ligand No_ligand 449 - 720 0 None None Serine/threonine-protein kinase B-raf
3Q4CB 3.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo No_ligand No_ligand 448 - 723 0 None None Serine/threonine-protein kinase B-raf
4MNEB 2.848 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioi No_ligand No_ligand 449 - 722 0 None None Serine/threonine-protein kinase B-raf
4MNEG 2.848 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioi No_ligand No_ligand 449 - 720 0 None None Serine/threonine-protein kinase B-raf
6UANC 3.9 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaini APEdist_iioo No_ligand No_ligand 449 - 733 0 SEP729 T373C,I374M Serine/threonine-protein kinase B-raf
6U2HC 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnno 29L Type1 448 - 733 0 SEP729 None Serine/threonine-protein kinase B-raf
6U2HD 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 29L Type1 448 - 733 0 SEP729 None Serine/threonine-protein kinase B-raf
4YHTA 3.05 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnno 4EF Type1 449 - 719 0 None I543T,I544N,I551T,L706T,L716T Serine/threonine-protein kinase B-raf
4YHTB 3.05 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnno 4EF Type1 449 - 720 0 None I543T,I544N,I551T,L706T,L716T Serine/threonine-protein kinase B-raf
2FB8A 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi 215 Type1 449 - 720 0 None None Serine/threonine-protein kinase B-raf
2FB8B 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnio 215 Type1 449 - 720 0 None None Serine/threonine-protein kinase B-raf
3D4QA 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaoio APEdist_nooo SM5 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf
3D4QB 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaoio APEdist_nooo SM5 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf
3PPKA 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno FNI Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf
3PPKB 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nioo FNI Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf
3PRIA 3.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooo FP4 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf
3PRIB 3.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooo FP4 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf
3PSBA 3.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno SM6 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf
3PSBB 3.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nioo SM6 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf
3PSDA 3.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno SM7 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf
3PSDB 3.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nioo SM7 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf
3Q4CA 3.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo RSW Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf
4E26A 2.55 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo 734 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf
7SHVA 2.88 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnio 29L Type1 449 - 721 0 None None Serine/threonine-protein kinase B-raf
4MNFB 2.802 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 29L Type1 449 - 720 0 None V600E Serine/threonine-protein kinase B-raf
7MFFA 3.89 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_nnoo 215 Type1 449 - 732 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf
7MFFB 3.89 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoi 215 Type1 449 - 733 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf
3PPJA 3.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnno FOI Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf
3PPJB 3.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nioo FOI Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf
7SHVB 2.88 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnio 29L Type1.5_Back 449 - 721 0 None None Serine/threonine-protein kinase B-raf
5JSMA 2.19 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_nnoo No_ligand No_ligand 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
5JSMD 2.19 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooi APEdist_nnoo No_ligand No_ligand 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
5JT2B 2.702 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 448 - 719 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
5JT2D 2.702 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 448 - 718 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
6UANB 3.9 Inactive DFGin‑BLAplus in-out in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 449 - 750 0 SEP729 T373C,I374M Serine/threonine-protein kinase B-raf
9BFBA 1.92 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooi APEdist_iooo A1AN9 Type1 448 - 721 0 None F667A,R671A,Y673A Serine/threonine-protein kinase B-raf
9BP8A 1.73 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_iooo A1AQY Type1 449 - 721 0 None F667A,R671A,Y673A Serine/threonine-protein kinase B-raf
5FD2B 2.89 Inactive DFGin‑BLAplus out-none none-out nonTYR APEdihe_aaiii APEdist_nnno 5XJ Type1 449 - 720 0 None None Serine/threonine-protein kinase B-raf
3SKCB 3.2 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooi APEdist_iooo BR2 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf
8VYUA 4.07 Inactive DFGin‑BLAplus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn A1AEN Type1 235 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf
4CQEA 2.3 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaoii APEdist_nnno CQE Type1.5_Back 449 - 720 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
5JRQA 2.287 Inactive DFGin‑BLAplus out-out out-none nonTYR APEdihe_aanii APEdist_nnnn 6N9 Type1.5_Back 448 - 719 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
5JRQB 2.287 Inactive DFGin‑BLAplus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn 6N9 Type1.5_Back 448 - 720 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
5JSMB 2.19 Inactive DFGin‑BLAplus out-out out-none nonTYR APEdihe_aanii APEdist_nnnn 6NB Type1.5_Back 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
5JSMC 2.19 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 6NB Type1.5_Back 448 - 722 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
5JT2A 2.702 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 6NC Type1.5_Back 448 - 719 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
5JT2C 2.702 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 6NC Type1.5_Back 448 - 719 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
4RZVA 2.994 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioo 032 Type1.5_Back 449 - 721 0 None R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
4RZVB 2.994 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo 032 Type1.5_Back 449 - 722 0 None R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
4XV1A 2.47 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 904 Type1.5_Back 449 - 705 0 None S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R Serine/threonine-protein kinase B-raf
4XV3A 2.8 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno P02 Type1.5_Back 448 - 705 0 None S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R Serine/threonine-protein kinase B-raf
4FK3A 2.65 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaiii APEdist_nnno 325 Type1.5_Back 448 - 718 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
6UUOB 3.288 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaooi APEdist_nnno QH1 Type1.5_Back 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
5ITAA 1.95 Inactive DFGin‑BLAplus out-out none-none nonTYR APEdihe_aanii APEdist_nnnn 6DC Type1.5_Back 448 - 718 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
4WO5A 2.83 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooo APEdist_iooo 324 Type1.5_Back 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
4WO5B 2.83 Inactive DFGin‑BLAplus out-none out-out nonTYR APEdihe_aaiii APEdist_nnno 324 Type1.5_Back 450 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
3OG7A 2.45 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 032 Type1.5_Back 449 - 720 0 None K522A,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf
4EHGA 3.5 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno RI9 Type1.5_Back 448 - 723 0 None V600E Serine/threonine-protein kinase B-raf
4EHGB 3.5 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaioi APEdist_nnoo RI9 Type1.5_Back 448 - 723 0 None V600E Serine/threonine-protein kinase B-raf
5FD2A 2.89 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_nnoo 5XJ Type1.5_Back 448 - 720 0 None None Serine/threonine-protein kinase B-raf
3TV4A 3.4 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_nnoo TV4 Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf
3TV4B 3.4 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_iooo TV4 Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf
3TV6A 3.3 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_nnoo B0R Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf
3TV6B 3.3 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_iooo B0R Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf
4E4XA 3.6 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooi APEdist_nooo T1Q Type1.5_Back 448 - 721 0 None None Serine/threonine-protein kinase B-raf
4E4XB 3.6 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooi APEdist_iooo T1Q Type1.5_Back 448 - 721 0 None None Serine/threonine-protein kinase B-raf
4EHEA 3.3 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooi APEdist_nnoo RI8 Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf
4EHEB 3.3 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooi APEdist_iooo RI8 Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf
4PP7A 3.4 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_nooo 2VX Type1.5_Back 448 - 721 0 None None Serine/threonine-protein kinase B-raf
4PP7B 3.4 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_iooo 2VX Type1.5_Back 448 - 721 0 None None Serine/threonine-protein kinase B-raf
8VYSA 3.06 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooi APEdist_nnno A1AEN Type1.5_Back 235 - 738 0 SEP365,SEP729 V600E Serine/threonine-protein kinase B-raf
3SKCA 3.2 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaooi APEdist_nnno BR2 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf
4E26B 2.55 Inactive DFGin‑BLBminus in-in in-out nonTYR APEdihe_aaoii APEdist_nnoo 734 Type1 448 - 722 0 None None Serine/threonine-protein kinase B-raf
5HIEA 3.0 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnno P06 Type1 449 - 722 0 None None Serine/threonine-protein kinase B-raf
5HIEB 3.0 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo P06 Type1 449 - 722 0 None None Serine/threonine-protein kinase B-raf
5HIEC 3.0 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaiii APEdist_nnoo P06 Type1 449 - 722 0 None None Serine/threonine-protein kinase B-raf
5HIED 3.0 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaiii APEdist_nnoo P06 Type1 449 - 722 0 None None Serine/threonine-protein kinase B-raf
7P3VA 2.37 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaoii APEdist_nnno 5I4 Type1.5_Back 448 - 719 0 None V600E Serine/threonine-protein kinase B-raf
7P3VB 2.37 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaoii APEdist_oooo 5I4 Type1.5_Back 448 - 719 0 None V600E Serine/threonine-protein kinase B-raf
4CQEB 2.3 Inactive DFGin‑BLBminus in-out none-out nonTYR APEdihe_aaoii APEdist_nnno CQE Type1.5_Back 448 - 720 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
4XV2A 2.5 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno P06 Type1.5_Back 449 - 705 0 None S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R Serine/threonine-protein kinase B-raf
4XV2B 2.5 Inactive DFGin‑BLBminus in-out none-out nonTYR APEdihe_aaoii APEdist_nnno P06 Type1.5_Back 448 - 705 0 None S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R Serine/threonine-protein kinase B-raf
5CSWB 2.66 Inactive DFGin‑BLBminus out-out none-none nonTYR APEdihe_aanii APEdist_nnnn P06 Type1.5_Back 447 - 721 0 None R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf
6V2UB 3.78 Inactive DFGin‑BLBminus out-out none-none nonTYR APEdihe_aanii APEdist_nnnn P06 Type1.5_Back 449 - 720 0 None None Serine/threonine-protein kinase B-raf
9AXYA 3.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 448 - 722 0 None None Serine/threonine-protein kinase B-raf
6PP9A 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 447 - 722 0 None None Serine/threonine-protein kinase B-raf
6V2WA 3.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 447 - 721 0 None None Serine/threonine-protein kinase B-raf
7M0TA 3.19 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioo APEdist_iooo ANP ATPlike 448 - 721 0 None None Serine/threonine-protein kinase B-raf
7M0UA 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 449 - 722 0 None None Serine/threonine-protein kinase B-raf
7M0VA 3.16 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_iooo ANP ATPlike 449 - 722 0 None None Serine/threonine-protein kinase B-raf
7M0WA 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 448 - 721 0 None None Serine/threonine-protein kinase B-raf
7M0XA 2.47 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 447 - 722 0 None None Serine/threonine-protein kinase B-raf
7M0YA 3.45 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 447 - 721 0 None None Serine/threonine-protein kinase B-raf
7M0ZA 3.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_iooo ANP ATPlike 449 - 721 0 None None Serine/threonine-protein kinase B-raf
9ECUA 3.46 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ANP ATPlike 447 - 722 0 None None Serine/threonine-protein kinase B-raf
6U2GB 2.886 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ACP ATPlike 451 - 722 0 None None Serine/threonine-protein kinase B-raf
6NYBA 4.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo AGS ATPlike 233 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf
8DGSA 4.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo AGS ATPlike 155 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf
8DGTA 3.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo AGS ATPlike 151 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf
7MFDA 3.66 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooi APEdist_iooo No_ligand No_ligand 156 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf
7MFEA 4.07 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_iooo No_ligand No_ligand 156 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf
9O2ZA 3.83 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_iooo No_ligand No_ligand 156 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf
8VYOA 3.74 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioo APEdist_nnno No_ligand No_ligand 235 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf
3C4CA 2.57 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 324 Type1.5_Back 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf
4XV3B 2.8 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaoii APEdist_nnno No_ligand No_ligand 448 - 705 0 None S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R Serine/threonine-protein kinase B-raf
4FK3B 2.65 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaooi APEdist_nnoo No_ligand No_ligand 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
3OG7B 2.45 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaoii APEdist_nnno No_ligand No_ligand 449 - 720 0 None K522A,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf
6UUOA 3.288 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaoii APEdist_nnno QH1 Type1 450 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
4H58A 3.1 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_nnio 10Z Type1 448 - 722 0 None None Serine/threonine-protein kinase B-raf
3PRFB 2.9 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaiii APEdist_nnno FP3 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf
5CSWA 2.66 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnno P06 Type1.5_Back 449 - 721 0 None R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf
5ITAB 1.95 Inactive DFGin‑None out-in none-out nonTYR APEdihe_aaoii APEdist_nnno 6DC Type1.5_Back 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
6V2UA 3.78 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaiii APEdist_nnno P06 Type1.5_Back 449 - 721 0 None None Serine/threonine-protein kinase B-raf
4MBJA 3.6 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nooo DFS Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf
4MBJB 3.6 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iooo DFS Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf
4H58C 3.1 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo No_ligand No_ligand 449 - 722 0 None None Serine/threonine-protein kinase B-raf
4G9RB 3.2 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnno B1E Type1 448 - 721 0 None V600E Serine/threonine-protein kinase B-raf
5CSXA 2.51 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaoii APEdist_nnoo 54J Type1.5_Back 448 - 720 0 None R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf
8C7YA 1.65 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo TXV Type2 448 - 721 0 None V600E Serine/threonine-protein kinase B-raf
8C7YB 1.65 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_nnno TXV Type2 449 - 721 0 None V600E Serine/threonine-protein kinase B-raf
6V34A 3.15 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnoo QOP Type2 449 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf
6V34B 3.15 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aannn APEdist_nnnn QOP Type2 449 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf
4R5YA 3.5 Inactive DFGout‑BBAminus in-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 3K3 Type2 449 - 720 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
4R5YB 3.5 Inactive DFGout‑BBAminus in-out out-out nonTYR APEdihe_aaoii APEdist_nnoo 3K3 Type2 449 - 720 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
6XFPA 2.0 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_iooo V1Y Type2 449 - 720 0 None None Serine/threonine-protein kinase B-raf
6XLOA 2.493 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo V5J Type2 449 - 720 0 None None Serine/threonine-protein kinase B-raf
6XLOB 2.493 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn V5J Type2 450 - 720 0 None None Serine/threonine-protein kinase B-raf
7K0VA 1.93 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_iooo VQP Type2 449 - 722 0 None None Serine/threonine-protein kinase B-raf
7K0VB 1.93 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_oooo VQP Type2 449 - 722 0 None None Serine/threonine-protein kinase B-raf
7K0VC 1.93 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_nnno VQP Type2 448 - 722 0 None None Serine/threonine-protein kinase B-raf
7K0VD 1.93 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo VQP Type2 449 - 722 0 None None Serine/threonine-protein kinase B-raf
6P3DA 2.11 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaooi APEdist_nnoo 0LI Type2 448 - 721 0 None None Serine/threonine-protein kinase B-raf
6P7GA 2.65 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo E7M Type2 449 - 720 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
6P7GC 2.65 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno E7M Type2 449 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
6P7GD 2.65 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo E7M Type2 449 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
8F7OA 3.54 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaooi APEdist_iioo QOP Type2 449 - 723 0 None None Serine/threonine-protein kinase B-raf
8F7OB 3.54 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_oooo QOP Type2 449 - 722 0 None None Serine/threonine-protein kinase B-raf
8F7PA 2.74 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_nnno K81 Type2 449 - 721 0 None None Serine/threonine-protein kinase B-raf
8F7PB 2.74 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_nioo K81 Type2 448 - 721 0 None None Serine/threonine-protein kinase B-raf
4JVGA 3.09 Inactive DFGout‑BBAminus in-in out-none nonTYR APEdihe_aanii APEdist_nnnn B96 Type2 448 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
4JVGB 3.09 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn B96 Type2 448 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
4JVGC 3.09 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn B96 Type2 448 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
4JVGD 3.09 Inactive DFGout‑BBAminus in-in out-none nonTYR APEdihe_aanii APEdist_nnnn B96 Type2 448 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
6CADA 2.55 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaooi APEdist_nnno EU4 Type2 449 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
6NSQA 3.05 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo KZP Type2 448 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
8C7XA 1.65 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo TXV Type2 449 - 721 0 None None Serine/threonine-protein kinase B-raf
8C7XB 1.65 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo TXV Type2 448 - 721 0 None None Serine/threonine-protein kinase B-raf
4XV9A 2.0 Inactive DFGout‑BBAminus out-out none-out nonTYR APEdihe_aaoii APEdist_nioo 1OO Type2 448 - 705 0 None R443S,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R Serine/threonine-protein kinase B-raf
5HI2A 2.512 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn BAX Type2 449 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
5HIDA 2.5 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaoii APEdist_iioo B1E Type2 449 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
5HIDB 2.5 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo B1E Type2 449 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
1UWJA 3.5 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno BAX Type2 448 - 723 0 None V600E Serine/threonine-protein kinase B-raf
1UWJB 3.5 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno BAX Type2 448 - 723 0 None V600E Serine/threonine-protein kinase B-raf
6N0PA 2.37 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_oioo K81 Type2 449 - 721 0 None None Serine/threonine-protein kinase B-raf
6N0PB 2.37 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaooi APEdist_nnoo K81 Type2 449 - 721 0 None None Serine/threonine-protein kinase B-raf
8QQGB 2.979 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nioo WJ9 Type2 448 - 721 0 None None Serine/threonine-protein kinase B-raf
8QQGC 2.979 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo WJ9 Type2 448 - 721 0 None None Serine/threonine-protein kinase B-raf
5CT7A 3.17 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 55J Type2 449 - 721 0 None None Serine/threonine-protein kinase B-raf
5VALA 2.26 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn 92D Type2 446 - 720 0 None None Serine/threonine-protein kinase B-raf
5VALB 2.26 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 92D Type2 448 - 721 0 None None Serine/threonine-protein kinase B-raf
5VAMA 2.1 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_oioo 92J Type2 449 - 721 0 None None Serine/threonine-protein kinase B-raf
5VAMB 2.1 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno 92J Type2 449 - 721 0 None None Serine/threonine-protein kinase B-raf
6B8UA 2.68 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 8EN Type2 449 - 720 0 None None Serine/threonine-protein kinase B-raf
6B8UB 2.68 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 8EN Type2 447 - 720 0 None None Serine/threonine-protein kinase B-raf
6N0QA 2.04 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaooi APEdist_nnno K7S Type2 446 - 721 0 None None Serine/threonine-protein kinase B-raf
6N0QB 2.04 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno K7S Type2 448 - 721 0 None None Serine/threonine-protein kinase B-raf
3Q96A 3.1 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 0NF Type2 449 - 722 0 None None Serine/threonine-protein kinase B-raf
3Q96B 3.1 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnno 0NF Type2 449 - 720 0 None None Serine/threonine-protein kinase B-raf
4DBNA 3.15 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 0JA Type2 448 - 721 0 None None Serine/threonine-protein kinase B-raf
4DBNB 3.15 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno 0JA Type2 448 - 720 0 None None Serine/threonine-protein kinase B-raf
4FC0A 2.95 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno 0T2 Type2 448 - 722 0 None None Serine/threonine-protein kinase B-raf
4FC0B 2.95 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnno 0T2 Type2 448 - 720 0 None None Serine/threonine-protein kinase B-raf
4KSPA 2.93 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno 1SU Type2 448 - 722 0 None None Serine/threonine-protein kinase B-raf
4KSPB 2.93 Inactive DFGout‑BBAminus in-out none-out nonTYR APEdihe_aaiii APEdist_nnno 1SU Type2 448 - 720 0 None None Serine/threonine-protein kinase B-raf
4KSQA 3.3 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 1SW Type2 448 - 722 0 None None Serine/threonine-protein kinase B-raf
4KSQB 3.3 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno 1SW Type2 449 - 720 0 None None Serine/threonine-protein kinase B-raf
3IDPA 2.7 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnno L1E Type2 449 - 720 0 None V600E Serine/threonine-protein kinase B-raf
3IDPB 2.7 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaooi APEdist_nnoo L1E Type2 449 - 720 0 None V600E Serine/threonine-protein kinase B-raf
4G9RA 3.2 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno B1E Type2 448 - 721 0 None V600E Serine/threonine-protein kinase B-raf
5C9CA 2.7 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn 4Z5 Type2 449 - 720 0 None V600E Serine/threonine-protein kinase B-raf
5C9CB 2.7 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 4Z5 Type2 449 - 720 0 None V600E Serine/threonine-protein kinase B-raf
1UWHA 2.95 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nioo BAX Type2 448 - 723 0 None None Serine/threonine-protein kinase B-raf
1UWHB 2.95 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nioo BAX Type2 448 - 723 0 None None Serine/threonine-protein kinase B-raf
3II5A 2.79 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaioi APEdist_iioo 831 Type2 448 - 720 0 None None Serine/threonine-protein kinase B-raf
3II5B 2.79 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno 831 Type2 449 - 721 0 None None Serine/threonine-protein kinase B-raf
4G9CA 3.5 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nooo 0WP Type2 448 - 723 0 None None Serine/threonine-protein kinase B-raf
4G9CB 3.5 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nioo 0WP Type2 448 - 723 0 None None Serine/threonine-protein kinase B-raf
6P7GB 2.65 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_iooo E7M, NHE Type2, Allosteric 449 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
4RZWA 3.493 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno B1E Type1 448 - 720 0 None R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
3C4CB 2.57 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaiii APEdist_nnno 324 Type1.5_Back 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf
4RZWB 3.493 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno B1E Type2 448 - 721 0 None R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
6CADB 2.55 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno EU4 Type2 449 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
6NSQB 3.05 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno KZP Type2 447 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
8QQGA 2.979 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_nnno WJ9 Type2 449 - 722 0 None None Serine/threonine-protein kinase B-raf
5CT7B 3.17 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 55J Type2 449 - 721 0 None None Serine/threonine-protein kinase B-raf
8VYPC 3.29 Inactive None‑None in-out none-none nonTYR APEdihe_aannn APEdist_nnnn AGS ATPlike 363 - 733 0 SEP365,SEP729 V600E Serine/threonine-protein kinase B-raf
8VYRA 4.32 Inactive None‑None in-none none-none nonTYR APEdihe_aanni APEdist_nnnn No_ligand No_ligand 361 - 736 0 SEP365,SEP729 V600E Serine/threonine-protein kinase B-raf
7ZR0K 3.4 Inactive None‑None none-none none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 521 - 724 0 None None Serine/threonine-protein kinase B-raf
7ZR5K 3.9 Inactive None‑None none-none none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 521 - 724 0 None None Serine/threonine-protein kinase B-raf
7ZR6K 4.2 Inactive None‑None none-none none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 521 - 724 0 None None Serine/threonine-protein kinase B-raf
6Q0JA 4.9 Inactive None‑None in-none in-out nonTYR APEdihe_aaini APEdist_iioi No_ligand No_ligand 449 - 733 0 SEP729 S365A Serine/threonine-protein kinase B-raf
6Q0JB 4.9 Inactive None‑None in-none in-out nonTYR APEdihe_aaini APEdist_iioi No_ligand No_ligand 449 - 734 0 SEP729 S365A Serine/threonine-protein kinase B-raf
6Q0TA 5.7 Inactive None‑None in-none in-out nonTYR APEdihe_aaini APEdist_iioi No_ligand No_ligand 449 - 732 0 SEP729 S365A Serine/threonine-protein kinase B-raf
6Q0TB 5.7 Inactive None‑None in-none in-out nonTYR APEdihe_aaini APEdist_iioi No_ligand No_ligand 449 - 730 0 SEP729 S365A Serine/threonine-protein kinase B-raf
6Q0KA 6.8 Inactive None‑None in-none in-out nonTYR APEdihe_aaini APEdist_iioi No_ligand No_ligand 449 - 737 0 SEP729 None Serine/threonine-protein kinase B-raf
6Q0KB 6.8 Inactive None‑None in-none in-out nonTYR APEdihe_aaini APEdist_iioi No_ligand No_ligand 449 - 733 0 SEP729 None Serine/threonine-protein kinase B-raf
8VYVC 5.86 Inactive None‑None in-none none-none nonTYR APEdihe_aanni APEdist_nnnn No_ligand No_ligand 362 - 733 0 SEP365,SEP729 K601E Serine/threonine-protein kinase B-raf
4MNFA 2.802 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn 29L Type1 449 - 720 0 None V600E Serine/threonine-protein kinase B-raf

TKL_BRAF (Serine/threonine-protein kinase B-raf)

Total number of chains: 218
Active chains: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 73 33.5% 8C7YA
DFGin BLAplus 41 18.8% 9BP8A
DFGin BLAminus 39 17.9% AF-P15056-K1A
DFGin BLBplus 20 9.2% 7M0XA
DFGin BLBminus 13 6.0% 7P3VB
None None 12 5.5% 6Q0JA
DFGin None 11 5.0% 4MBJB
DFGout None 7 3.2% 8QQGA
DFGin ABAminus 2 0.9% 4H58B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
BRAF_HUMAN AF-P15056-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 449 - 724 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN AF-P15056-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 449 - 724 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4MNEC 2.848 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 449 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4MNEF 2.848 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4H58B 3.1 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaoii APEdist_nooo No_ligand No_ligand 448 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3PRFA 2.9 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaioo APEdist_nnno FP3 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 9AXXB 2.07 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4XV1B 2.47 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aanii APEdist_nnnn No_ligand No_ligand 449 - 705 0 None S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6XAGC 3.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 449 - 732 0 SEP729 None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6XAGD 3.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nioo No_ligand No_ligand 448 - 733 0 SEP729 None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 9AXXD 2.07 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi No_ligand No_ligand 449 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3Q4CB 3.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo No_ligand No_ligand 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4MNEB 2.848 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioi No_ligand No_ligand 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4MNEG 2.848 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioi No_ligand No_ligand 449 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6UANC 3.9 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaini APEdist_iioo No_ligand No_ligand 449 - 733 0 SEP729 T373C,I374M Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6U2HC 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnno 29L Type1 448 - 733 0 SEP729 None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6U2HD 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 29L Type1 448 - 733 0 SEP729 None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4YHTA 3.05 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnno 4EF Type1 449 - 719 0 None I543T,I544N,I551T,L706T,L716T Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4YHTB 3.05 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnno 4EF Type1 449 - 720 0 None I543T,I544N,I551T,L706T,L716T Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 2FB8A 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi 215 Type1 449 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 2FB8B 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnio 215 Type1 449 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3D4QA 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaoio APEdist_nooo SM5 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3D4QB 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaoio APEdist_nooo SM5 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3PPKA 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno FNI Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3PPKB 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nioo FNI Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3PRIA 3.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooo FP4 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3PRIB 3.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooo FP4 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3PSBA 3.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno SM6 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3PSBB 3.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nioo SM6 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3PSDA 3.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno SM7 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3PSDB 3.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nioo SM7 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3Q4CA 3.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo RSW Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4E26A 2.55 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oooo 734 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7SHVA 2.88 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnio 29L Type1 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4MNFB 2.802 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 29L Type1 449 - 720 0 None V600E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7MFFA 3.89 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_nnoo 215 Type1 449 - 732 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7MFFB 3.89 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoi 215 Type1 449 - 733 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3PPJA 3.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnno FOI Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3PPJB 3.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nioo FOI Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7SHVB 2.88 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnio 29L Type1.5_Back 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5JSMA 2.19 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_nnoo No_ligand No_ligand 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5JSMD 2.19 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooi APEdist_nnoo No_ligand No_ligand 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5JT2B 2.702 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 448 - 719 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5JT2D 2.702 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 448 - 718 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6UANB 3.9 Inactive DFGin‑BLAplus in-out in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 449 - 750 0 SEP729 T373C,I374M Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 9BFBA 1.92 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooi APEdist_iooo A1AN9 Type1 448 - 721 0 None F667A,R671A,Y673A Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 9BP8A 1.73 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_iooo A1AQY Type1 449 - 721 0 None F667A,R671A,Y673A Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5FD2B 2.89 Inactive DFGin‑BLAplus out-none none-out nonTYR APEdihe_aaiii APEdist_nnno 5XJ Type1 449 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3SKCB 3.2 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooi APEdist_iooo BR2 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 8VYUA 4.07 Inactive DFGin‑BLAplus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn A1AEN Type1 235 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4CQEA 2.3 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaoii APEdist_nnno CQE Type1.5_Back 449 - 720 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5JRQA 2.287 Inactive DFGin‑BLAplus out-out out-none nonTYR APEdihe_aanii APEdist_nnnn 6N9 Type1.5_Back 448 - 719 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5JRQB 2.287 Inactive DFGin‑BLAplus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn 6N9 Type1.5_Back 448 - 720 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5JSMB 2.19 Inactive DFGin‑BLAplus out-out out-none nonTYR APEdihe_aanii APEdist_nnnn 6NB Type1.5_Back 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5JSMC 2.19 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 6NB Type1.5_Back 448 - 722 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5JT2A 2.702 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 6NC Type1.5_Back 448 - 719 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5JT2C 2.702 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 6NC Type1.5_Back 448 - 719 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4RZVA 2.994 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioo 032 Type1.5_Back 449 - 721 0 None R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4RZVB 2.994 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo 032 Type1.5_Back 449 - 722 0 None R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4XV1A 2.47 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 904 Type1.5_Back 449 - 705 0 None S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4XV3A 2.8 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno P02 Type1.5_Back 448 - 705 0 None S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4FK3A 2.65 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaiii APEdist_nnno 325 Type1.5_Back 448 - 718 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6UUOB 3.288 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaooi APEdist_nnno QH1 Type1.5_Back 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5ITAA 1.95 Inactive DFGin‑BLAplus out-out none-none nonTYR APEdihe_aanii APEdist_nnnn 6DC Type1.5_Back 448 - 718 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4WO5A 2.83 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooo APEdist_iooo 324 Type1.5_Back 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4WO5B 2.83 Inactive DFGin‑BLAplus out-none out-out nonTYR APEdihe_aaiii APEdist_nnno 324 Type1.5_Back 450 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3OG7A 2.45 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 032 Type1.5_Back 449 - 720 0 None K522A,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4EHGA 3.5 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno RI9 Type1.5_Back 448 - 723 0 None V600E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4EHGB 3.5 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaioi APEdist_nnoo RI9 Type1.5_Back 448 - 723 0 None V600E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5FD2A 2.89 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_nnoo 5XJ Type1.5_Back 448 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3TV4A 3.4 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_nnoo TV4 Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3TV4B 3.4 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_iooo TV4 Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3TV6A 3.3 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_nnoo B0R Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3TV6B 3.3 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_iooo B0R Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4E4XA 3.6 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooi APEdist_nooo T1Q Type1.5_Back 448 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4E4XB 3.6 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooi APEdist_iooo T1Q Type1.5_Back 448 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4EHEA 3.3 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooi APEdist_nnoo RI8 Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4EHEB 3.3 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooi APEdist_iooo RI8 Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4PP7A 3.4 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_nooo 2VX Type1.5_Back 448 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4PP7B 3.4 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaoii APEdist_iooo 2VX Type1.5_Back 448 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 8VYSA 3.06 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaooi APEdist_nnno A1AEN Type1.5_Back 235 - 738 0 SEP365,SEP729 V600E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3SKCA 3.2 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaooi APEdist_nnno BR2 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4E26B 2.55 Inactive DFGin‑BLBminus in-in in-out nonTYR APEdihe_aaoii APEdist_nnoo 734 Type1 448 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5HIEA 3.0 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnno P06 Type1 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5HIEB 3.0 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo P06 Type1 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5HIEC 3.0 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaiii APEdist_nnoo P06 Type1 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5HIED 3.0 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaiii APEdist_nnoo P06 Type1 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7P3VA 2.37 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaoii APEdist_nnno 5I4 Type1.5_Back 448 - 719 0 None V600E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7P3VB 2.37 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaoii APEdist_oooo 5I4 Type1.5_Back 448 - 719 0 None V600E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4CQEB 2.3 Inactive DFGin‑BLBminus in-out none-out nonTYR APEdihe_aaoii APEdist_nnno CQE Type1.5_Back 448 - 720 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4XV2A 2.5 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno P06 Type1.5_Back 449 - 705 0 None S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4XV2B 2.5 Inactive DFGin‑BLBminus in-out none-out nonTYR APEdihe_aaoii APEdist_nnno P06 Type1.5_Back 448 - 705 0 None S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5CSWB 2.66 Inactive DFGin‑BLBminus out-out none-none nonTYR APEdihe_aanii APEdist_nnnn P06 Type1.5_Back 447 - 721 0 None R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6V2UB 3.78 Inactive DFGin‑BLBminus out-out none-none nonTYR APEdihe_aanii APEdist_nnnn P06 Type1.5_Back 449 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 9AXYA 3.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 448 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6PP9A 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 447 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6V2WA 3.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 447 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7M0TA 3.19 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioo APEdist_iooo ANP ATPlike 448 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7M0UA 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7M0VA 3.16 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_iooo ANP ATPlike 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7M0WA 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 448 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7M0XA 2.47 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 447 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7M0YA 3.45 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 447 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7M0ZA 3.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_iooo ANP ATPlike 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 9ECUA 3.46 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ANP ATPlike 447 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6U2GB 2.886 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ACP ATPlike 451 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6NYBA 4.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo AGS ATPlike 233 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 8DGSA 4.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo AGS ATPlike 155 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 8DGTA 3.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo AGS ATPlike 151 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7MFDA 3.66 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooi APEdist_iooo No_ligand No_ligand 156 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7MFEA 4.07 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_iooo No_ligand No_ligand 156 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 9O2ZA 3.83 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_iooo No_ligand No_ligand 156 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 8VYOA 3.74 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioo APEdist_nnno No_ligand No_ligand 235 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3C4CA 2.57 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 324 Type1.5_Back 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4XV3B 2.8 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaoii APEdist_nnno No_ligand No_ligand 448 - 705 0 None S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4FK3B 2.65 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaooi APEdist_nnoo No_ligand No_ligand 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3OG7B 2.45 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaoii APEdist_nnno No_ligand No_ligand 449 - 720 0 None K522A,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6UUOA 3.288 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaoii APEdist_nnno QH1 Type1 450 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4H58A 3.1 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_nnio 10Z Type1 448 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3PRFB 2.9 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaiii APEdist_nnno FP3 Type1 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5CSWA 2.66 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnno P06 Type1.5_Back 449 - 721 0 None R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5ITAB 1.95 Inactive DFGin‑None out-in none-out nonTYR APEdihe_aaoii APEdist_nnno 6DC Type1.5_Back 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6V2UA 3.78 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaiii APEdist_nnno P06 Type1.5_Back 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4MBJA 3.6 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nooo DFS Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4MBJB 3.6 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iooo DFS Type1.5_Back 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4H58C 3.1 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo No_ligand No_ligand 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4G9RB 3.2 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnno B1E Type1 448 - 721 0 None V600E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5CSXA 2.51 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaoii APEdist_nnoo 54J Type1.5_Back 448 - 720 0 None R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 8C7YA 1.65 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo TXV Type2 448 - 721 0 None V600E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 8C7YB 1.65 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_nnno TXV Type2 449 - 721 0 None V600E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6V34A 3.15 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnoo QOP Type2 449 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6V34B 3.15 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aannn APEdist_nnnn QOP Type2 449 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4R5YA 3.5 Inactive DFGout‑BBAminus in-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 3K3 Type2 449 - 720 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4R5YB 3.5 Inactive DFGout‑BBAminus in-out out-out nonTYR APEdihe_aaoii APEdist_nnoo 3K3 Type2 449 - 720 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6XFPA 2.0 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_iooo V1Y Type2 449 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6XLOA 2.493 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo V5J Type2 449 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6XLOB 2.493 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn V5J Type2 450 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7K0VA 1.93 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_iooo VQP Type2 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7K0VB 1.93 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_oooo VQP Type2 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7K0VC 1.93 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_nnno VQP Type2 448 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7K0VD 1.93 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo VQP Type2 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6P3DA 2.11 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaooi APEdist_nnoo 0LI Type2 448 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6P7GA 2.65 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo E7M Type2 449 - 720 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6P7GC 2.65 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnno E7M Type2 449 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6P7GD 2.65 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo E7M Type2 449 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 8F7OA 3.54 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaooi APEdist_iioo QOP Type2 449 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 8F7OB 3.54 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_oooo QOP Type2 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 8F7PA 2.74 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_nnno K81 Type2 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 8F7PB 2.74 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_nioo K81 Type2 448 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4JVGA 3.09 Inactive DFGout‑BBAminus in-in out-none nonTYR APEdihe_aanii APEdist_nnnn B96 Type2 448 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4JVGB 3.09 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn B96 Type2 448 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4JVGC 3.09 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn B96 Type2 448 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4JVGD 3.09 Inactive DFGout‑BBAminus in-in out-none nonTYR APEdihe_aanii APEdist_nnnn B96 Type2 448 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6CADA 2.55 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaooi APEdist_nnno EU4 Type2 449 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6NSQA 3.05 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo KZP Type2 448 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 8C7XA 1.65 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo TXV Type2 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 8C7XB 1.65 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo TXV Type2 448 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4XV9A 2.0 Inactive DFGout‑BBAminus out-out none-out nonTYR APEdihe_aaoii APEdist_nioo 1OO Type2 448 - 705 0 None R443S,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5HI2A 2.512 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn BAX Type2 449 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5HIDA 2.5 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaoii APEdist_iioo B1E Type2 449 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5HIDB 2.5 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_iioo B1E Type2 449 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 1UWJA 3.5 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno BAX Type2 448 - 723 0 None V600E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 1UWJB 3.5 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno BAX Type2 448 - 723 0 None V600E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6N0PA 2.37 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_oioo K81 Type2 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6N0PB 2.37 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaooi APEdist_nnoo K81 Type2 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 8QQGB 2.979 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nioo WJ9 Type2 448 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 8QQGC 2.979 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo WJ9 Type2 448 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5CT7A 3.17 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 55J Type2 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5VALA 2.26 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn 92D Type2 446 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5VALB 2.26 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 92D Type2 448 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5VAMA 2.1 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_oioo 92J Type2 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5VAMB 2.1 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno 92J Type2 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6B8UA 2.68 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 8EN Type2 449 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6B8UB 2.68 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 8EN Type2 447 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6N0QA 2.04 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaooi APEdist_nnno K7S Type2 446 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6N0QB 2.04 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno K7S Type2 448 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3Q96A 3.1 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 0NF Type2 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3Q96B 3.1 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnno 0NF Type2 449 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4DBNA 3.15 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 0JA Type2 448 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4DBNB 3.15 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno 0JA Type2 448 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4FC0A 2.95 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno 0T2 Type2 448 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4FC0B 2.95 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnno 0T2 Type2 448 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4KSPA 2.93 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno 1SU Type2 448 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4KSPB 2.93 Inactive DFGout‑BBAminus in-out none-out nonTYR APEdihe_aaiii APEdist_nnno 1SU Type2 448 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4KSQA 3.3 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 1SW Type2 448 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4KSQB 3.3 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno 1SW Type2 449 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3IDPA 2.7 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnno L1E Type2 449 - 720 0 None V600E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3IDPB 2.7 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaooi APEdist_nnoo L1E Type2 449 - 720 0 None V600E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4G9RA 3.2 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno B1E Type2 448 - 721 0 None V600E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5C9CA 2.7 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn 4Z5 Type2 449 - 720 0 None V600E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5C9CB 2.7 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 4Z5 Type2 449 - 720 0 None V600E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 1UWHA 2.95 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nioo BAX Type2 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 1UWHB 2.95 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nioo BAX Type2 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3II5A 2.79 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaioi APEdist_iioo 831 Type2 448 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3II5B 2.79 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno 831 Type2 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4G9CA 3.5 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nooo 0WP Type2 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4G9CB 3.5 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nioo 0WP Type2 448 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6P7GB 2.65 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_iooo E7M, NHE Type2, Allosteric 449 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4RZWA 3.493 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno B1E Type1 448 - 720 0 None R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 3C4CB 2.57 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaiii APEdist_nnno 324 Type1.5_Back 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4RZWB 3.493 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno B1E Type2 448 - 721 0 None R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6CADB 2.55 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno EU4 Type2 449 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6NSQB 3.05 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno KZP Type2 447 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 8QQGA 2.979 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_nnno WJ9 Type2 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 5CT7B 3.17 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 55J Type2 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 8VYPC 3.29 Inactive None‑None in-out none-none nonTYR APEdihe_aannn APEdist_nnnn AGS ATPlike 363 - 733 0 SEP365,SEP729 V600E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 8VYRA 4.32 Inactive None‑None in-none none-none nonTYR APEdihe_aanni APEdist_nnnn No_ligand No_ligand 361 - 736 0 SEP365,SEP729 V600E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7ZR0K 3.4 Inactive None‑None none-none none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 521 - 724 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7ZR5K 3.9 Inactive None‑None none-none none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 521 - 724 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 7ZR6K 4.2 Inactive None‑None none-none none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 521 - 724 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6Q0JA 4.9 Inactive None‑None in-none in-out nonTYR APEdihe_aaini APEdist_iioi No_ligand No_ligand 449 - 733 0 SEP729 S365A Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6Q0JB 4.9 Inactive None‑None in-none in-out nonTYR APEdihe_aaini APEdist_iioi No_ligand No_ligand 449 - 734 0 SEP729 S365A Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6Q0TA 5.7 Inactive None‑None in-none in-out nonTYR APEdihe_aaini APEdist_iioi No_ligand No_ligand 449 - 732 0 SEP729 S365A Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6Q0TB 5.7 Inactive None‑None in-none in-out nonTYR APEdihe_aaini APEdist_iioi No_ligand No_ligand 449 - 730 0 SEP729 S365A Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6Q0KA 6.8 Inactive None‑None in-none in-out nonTYR APEdihe_aaini APEdist_iioi No_ligand No_ligand 449 - 737 0 SEP729 None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 6Q0KB 6.8 Inactive None‑None in-none in-out nonTYR APEdihe_aaini APEdist_iioi No_ligand No_ligand 449 - 733 0 SEP729 None Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 8VYVC 5.86 Inactive None‑None in-none none-none nonTYR APEdihe_aanni APEdist_nnnn No_ligand No_ligand 362 - 733 0 SEP365,SEP729 K601E Serine/threonine-protein kinase B-raf Homo sapiens
BRAF_HUMAN 4MNFA 2.802 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn 29L Type1 449 - 720 0 None V600E Serine/threonine-protein kinase B-raf Homo sapiens

TKL_BRAF (Serine/threonine-protein kinase B-raf)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism