Ligand: QOP (Tovorafenib, Ojemda)

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 4 100.0% 8F7OB
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TKL BRAF BRAF_HUMAN 6V34A 3.15 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnoo QOP Type2 449 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6V34B 3.15 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aannn APEdist_nnnn QOP Type2 449 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 8F7OA 3.54 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaooi APEdist_iioo QOP Type2 449 - 723 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 8F7OB 3.54 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_oooo QOP Type2 449 - 722 0 None None Serine/threonine-protein kinase B-raf

Ligand: QOP (Tovorafenib, Ojemda)

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 4 100.0% 8F7OB
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Advanced page
Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TKL BRAF BRAF_HUMAN 6V34A 3.15 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnoo QOP Type2 449 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 6V34B 3.15 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aannn APEdist_nnnn QOP Type2 449 - 721 0 None I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 8F7OA 3.54 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaooi APEdist_iioo QOP Type2 449 - 723 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 8F7OB 3.54 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_oooo QOP Type2 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens

Ligand: QOP (Tovorafenib, Ojemda)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Advanced page
Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism