TKL_BRAF (Serine/threonine-protein kinase B-raf)

Total number of chains: 218
Active chains: 4
Family: TKL
Uniprot: BRAF_HUMAN
Kinase Domain Residues: 457 - 716
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 73 33.5% 8C7YA
DFGin BLAplus 41 18.8% 9BP8A
DFGin BLAminus 39 17.9% AF-P15056-K1A
DFGin BLBplus 20 9.2% 7M0XA
DFGin BLBminus 13 6.0% 7P3VB
None None 12 5.5% 6Q0JA
DFGin None 11 5.0% 4MBJB
DFGout None 7 3.2% 8QQGA
DFGin ABAminus 2 0.9% 4H58B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P15056-K1A 449 724 766.0 No_ligand No_ligand Active DFGin 6.578 14.002 BLAminus -136.42, -168.61 54.52, 78.24 -91.38, 15.3 291.45, 90.84 -61.05, -27.93 in-in in 8.73 Saltbr-in 2.806 HRD-in -73.46, -42.74 68.11, -17.22 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.87, 119.19 APE9-dihe-na 120.45, -176.86 APE8-dihe-in -87.87, 116.2 APE8-rot-in 298.87 APE67-dihe-in -55.14, -36.76 -47.67, -38.83 APE12-dist-in 12.648 APE11-dist-in 12.303 APE10-dist-in 6.871 APE9-dist-in 5.7 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[457, 716]] 1.0 AF-P15056-K1 TKL_BRAF_HUMAN TKL 7.4e-82 280.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
AF-P15056-K3A 449 724 766.0 No_ligand No_ligand Active DFGin 6.489 13.906 BLAminus -136.13, -161.95 56.79, 58.46 -83.12, 17.87 298.48, 102.52 -58.43, -33.8 in-in in 7.988 Saltbr-in 2.695 HRD-in -75.87, -39.62 66.63, -12.61 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.1, 139.45 APE9-dihe-na 110.12, -162.95 APE8-dihe-in -111.8, 115.95 APE8-rot-in 306.17 APE67-dihe-in -66.26, -25.72 -56.57, -34.14 APE12-dist-in 11.842 APE11-dist-in 12.109 APE10-dist-in 6.41 APE9-dist-in 4.023 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[457, 716]] 1.0 AF-P15056-K3 TKL_BRAF_HUMAN TKL 7.4e-82 280.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4MNEC 449 720 766.0 No_ligand No_ligand Active DFGin 6.31 14.127 BLAminus -116.31, -150.46 30.76, 90.61 -104.11, 27.82 277.24, 67.68 -70.79, -9.9 in-in in 8.744 Saltbr-in 2.439 HRD-in -70.5, -40.5 60.78, 9.72 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.23, 133.86 APE9-dihe-na 149.56, -167.49 APE8-dihe-in -112.25, 121.13 APE8-rot-in 303.71 APE67-dihe-in -62.07, -20.02 -56.34, -38.04 APE12-dist-in 12.159 APE11-dist-in 11.556 APE10-dist-in 7.51 APE9-dist-in 5.815 None None None XRAY 2.848 0.186 0.24 C 308 260 12 0 0 7 [[457, 716]] 1.0 4mne TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4MNEF 449 721 766.0 No_ligand No_ligand Active DFGin 6.476 13.745 BLAminus -130.3, -157.72 45.09, 83.38 -99.59, 25.57 282.18, 62.71 -60.3, -26.4 in-in in 8.685 Saltbr-in 2.75 HRD-in -78.22, -41.28 65.37, 2.99 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.88, 144.35 APE9-dihe-na 131.47, -165.54 APE8-dihe-in -107.46, 126.01 APE8-rot-in 299.7 APE67-dihe-in -57.35, -35.84 -68.63, -28.44 APE12-dist-in 12.528 APE11-dist-in 11.988 APE10-dist-in 7.516 APE9-dist-in 5.875 None None None XRAY 2.848 0.186 0.24 F 308 258 15 0 0 9 [[457, 716]] 1.0 4mne TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4H58B 448 722 766.0 No_ligand No_ligand Inactive DFGin 6.84 14.824 ABAminus -98.82, -88.13 -93.34, 121.12 -119.32, 28.65 302.28, 124.2 -55.88, -57.22 in-in in 8.27 Saltbr-in 3.392 HRD-in -67.57, -56.11 87.58, -17.44 in-in-out SNCiio in-out ActLoopNT-in 3.02 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na 58.08, 30.11 APE9-dihe-na 109.46, 38.41 APE8-dihe-out -130.74, 22.57 APE8-rot-in 295.42 APE67-dihe-in -65.56, -25.13 -73.36, -24.11 APE12-dist-none 999.0 APE11-dist-out 14.043 APE10-dist-out 13.463 APE9-dist-out 11.108 None None None XRAY 3.1 0.224 0.272 B 275 262 13 0 0 13 [[457, 716]] 1.0 4h58 TKL_BRAF_HUMAN TKL 7.3e-82 280.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3PRFA 448 723 766.0 FP3:727 Type1 Inactive DFGin 6.396 13.706 ABAminus -158.36, 65.71 -149.53, 120.08 -122.92, 49.77 297.22, 87.28 -80.96, 85.15 in-in in 8.203 Saltbr-in 2.752 HRD-in -72.88, -40.09 60.57, 12.2 in-out-out SNCioo out-out ActLoopNT-out 5.394 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 128.3 APE8-dihe-in -99.37, 109.81 APE8-rot-out 47.4 APE67-dihe-out 95.65, -37.23 -70.26, -89.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.293 None None None XRAY 2.9 0.271 0.31 A 307 262 14 0 0 14 [[457, 716]] 1.0 3prf TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
9AXXB 449 721 766.0 ANP:60801 ATPlike Inactive DFGin 6.272 14.156 BLAminus -118.96, -160.68 44.13, 79.21 -91.3, 29.71 285.28, 70.2 -64.85, -24.03 in-out in 8.968 Saltbr-out 6.042 HRD-in -74.42, -44.59 66.93, 5.21 out-in-in SNCoii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.1, 120.32 APE9-dihe-na 137.74, -165.97 APE8-dihe-in -102.01, 122.38 APE8-rot-in 304.65 APE67-dihe-in -63.13, -30.61 -66.04, -26.1 APE12-dist-in 13.099 APE11-dist-in 12.628 APE10-dist-in 7.472 APE9-dist-in 5.708 None None None XRAY 2.07 0.215 0.248 B 280 261 12 0 0 6 [[457, 716]] 1.0 9axx TKL_BRAF_HUMAN TKL 7.8e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4XV1B 449 705 766.0 No_ligand No_ligand Inactive DFGin 6.294 14.61 BLAminus -145.75, -149.46 45.86, 66.44 -86.18, 28.57 259.03, 77.6 -56.14, -27.52 in-out in 8.843 Saltbr-out 4.117 HRD-in -70.86, -48.46 69.69, 2.81 out-in-none SNCoin in-none ActLoopNT-in 3.027 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -2.07 APE8-rot-in 300.39 APE67-dihe-in -68.18, -18.6 -56.02, -38.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R None None XRAY 2.47 0.236 0.273 B 292 233 24 0 0 15 [[457, 716]] 1.0 4xv1 TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6XAGC 449 732 766.0 No_ligand No_ligand Inactive DFGin 6.514 14.119 BLAminus -135.38, 176.92 64.87, 80.23 -95.35, 23.32 284.06, 65.51 -66.44, -29.75 in-in in 8.966 Saltbr-in 2.407 HRD-in -79.02, -38.34 63.13, 1.72 in-in-out SNCiio in-out ActLoopNT-in 2.912 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -34.9 APE8-dihe-in -75.72, 91.46 APE8-rot-out 85.17 APE67-dihe-in -63.91, -36.72 -120.11, -4.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.233 None SEP729 SEP729 XRAY 3.3 0.252 0.3 C 290 276 8 0 0 7 [[457, 716]] 1.0 6xag TKL_BRAF_HUMAN TKL 5.2e-84 287.9 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6XAGD 448 733 766.0 No_ligand No_ligand Inactive DFGin 6.503 13.633 BLAminus -140.73, -174.41 58.18, 74.07 -91.48, 27.0 290.75, 52.26 -65.73, -26.35 in-in in 8.956 Saltbr-in 2.598 HRD-in -81.24, -40.38 63.54, 1.85 in-in-out SNCiio in-out ActLoopNT-in 2.803 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na 58.02, -132.89 APE9-dihe-na -103.64, -7.92 APE8-dihe-in -77.52, 80.03 APE8-rot-out 82.48 APE67-dihe-in -75.94, -11.64 -83.69, -22.48 APE12-dist-none 999.0 APE11-dist-in 9.313 APE10-dist-out 10.954 APE9-dist-out 10.923 None SEP729 SEP729 XRAY 3.3 0.252 0.3 D 290 278 8 0 0 5 [[457, 716]] 1.0 6xag TKL_BRAF_HUMAN TKL 5.2e-84 287.9 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
9AXXD 449 720 766.0 No_ligand No_ligand Inactive DFGin 6.384 14.198 BLAminus -129.89, -173.73 62.98, 88.51 -109.58, 28.81 291.63, 88.61 -59.73, -40.17 in-in in 8.176 Saltbr-in 2.745 HRD-in -72.62, -47.14 70.14, -3.87 in-in-out SNCiio in-out ActLoopNT-in 2.848 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -147.43, 156.79 APE9-dihe-na -104.74, -133.5 APE8-dihe-in -87.21, 139.54 APE8-rot-in 302.48 APE67-dihe-in -63.49, -37.11 -65.97, -35.07 APE12-dist-in 10.401 APE11-dist-out 6.024 APE10-dist-out 9.101 APE9-dist-in 4.67 None None None XRAY 2.07 0.215 0.248 D 280 272 0 0 0 0 [[457, 716]] 1.0 9axx TKL_BRAF_HUMAN TKL 7.8e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3Q4CB 448 723 766.0 No_ligand No_ligand Inactive DFGin 6.545 14.559 BLAminus -146.12, -159.83 35.91, 93.44 -110.83, 27.67 289.71, 99.42 -62.68, -9.95 in-in in 8.148 Saltbr-in 3.051 HRD-in -70.95, -56.96 74.51, 13.37 in-in-out SNCiio in-out ActLoopNT-in 2.87 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 84.43 APE9-dihe-na -83.51, 57.43 APE8-dihe-in -129.0, 61.86 APE8-rot-out 58.54 APE67-dihe-in -58.42, -27.85 -82.03, -13.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.208 APE9-dist-out 10.973 None None None XRAY 3.2 0.232 0.28 B 307 264 12 0 0 12 [[457, 716]] 1.0 3q4c TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4MNEB 449 722 766.0 No_ligand No_ligand Inactive DFGin 6.382 14.165 BLAminus -125.74, -157.34 46.68, 85.76 -102.98, 25.57 282.33, 63.28 -59.91, -20.47 in-in in 8.812 Saltbr-in 3.014 HRD-in -72.72, -45.6 70.84, -1.11 in-in-out SNCiio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -136.48, 156.53 APE9-dihe-na 140.48, 169.17 APE8-dihe-in -83.53, 130.6 APE8-rot-in 280.97 APE67-dihe-in -60.93, -19.54 -69.93, -34.89 APE12-dist-in 12.006 APE11-dist-in 11.471 APE10-dist-out 8.112 APE9-dist-in 5.607 None None None XRAY 2.848 0.186 0.24 B 308 270 4 0 0 0 [[457, 716]] 1.0 4mne TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4MNEG 449 720 766.0 No_ligand No_ligand Inactive DFGin 6.351 14.005 BLAminus -133.48, -159.53 39.44, 81.15 -97.21, 35.04 282.93, 67.03 -73.28, -12.15 in-in in 8.979 Saltbr-in 2.571 HRD-in -72.6, -50.8 70.28, 6.2 in-in-out SNCiio in-out ActLoopNT-in 2.881 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -151.59, 152.98 APE9-dihe-na 137.55, -171.6 APE8-dihe-in -109.27, 119.72 APE8-rot-in 306.4 APE67-dihe-in -64.78, -21.88 -56.06, -36.62 APE12-dist-in 12.029 APE11-dist-in 11.478 APE10-dist-out 8.056 APE9-dist-in 5.674 None None None XRAY 2.848 0.186 0.24 G 308 259 13 0 0 8 [[457, 716]] 1.0 4mne TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6UANC 449 733 766.0 No_ligand No_ligand Inactive DFGin 6.722 15.086 BLAminus -133.66, -145.42 58.01, 67.46 -89.23, 29.8 285.54, 141.38 -68.94, -15.87 in-out in 9.453 Saltbr-out 5.351 HRD-out -71.43, 94.34 -71.05, -36.25 out-in-out SNCoio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioo APE10-dihe-na -159.48, 168.73 APE9-dihe-na -90.57, 11.03 APE8-dihe-in -91.34, 50.74 APE8-rot-none 999.0 APE67-dihe-in -76.53, -9.36 -80.03, -36.5 APE12-dist-in 13.374 APE11-dist-in 12.637 APE10-dist-out 10.006 APE9-dist-out 11.619 T373C,I374M SEP729 SEP729 EM 3.9 999.0 999.0 C 768 285 0 0 0 0 [[457, 716]] 1.0 6uan TKL_BRAF_HUMAN TKL 1.3e-80 277.1 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6U2HC 448 733 766.0 29L:60801 Type1 Inactive DFGin 6.75 14.236 BLAminus -140.81, -173.87 57.62, 73.3 -90.9, 27.8 291.38, 51.17 -64.94, -25.09 in-in in 8.624 Saltbr-in 2.732 HRD-in -81.66, -40.52 63.75, 1.44 in-in-out SNCiio in-out ActLoopNT-in 2.831 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -6.73 APE8-dihe-in -77.44, 81.11 APE8-rot-in 298.33 APE67-dihe-in -77.58, -10.43 -81.03, -23.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.369 None SEP729 SEP729 XRAY 2.5 0.222 0.263 C 290 275 11 0 0 11 [[457, 716]] 1.0 6u2h TKL_BRAF_HUMAN TKL 5.2e-84 287.9 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6U2HD 448 733 766.0 29L:60801 Type1 Inactive DFGin 6.362 13.853 BLAminus -135.68, 175.39 64.72, 81.19 -94.93, 22.46 283.79, 66.21 -67.34, -30.28 in-in in 8.599 Saltbr-in 2.78 HRD-in -78.94, -38.38 63.06, 1.76 in-in-out SNCiio in-out ActLoopNT-in 2.96 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 55.45, -147.38 APE9-dihe-na -70.68, -35.18 APE8-dihe-in -76.57, 92.11 APE8-rot-out 85.56 APE67-dihe-in -62.26, -37.46 -120.91, -2.65 APE12-dist-in 8.832 APE11-dist-in 9.503 APE10-dist-out 11.387 APE9-dist-out 11.583 None SEP729 SEP729 XRAY 2.5 0.222 0.263 D 290 283 3 0 0 3 [[457, 716]] 1.0 6u2h TKL_BRAF_HUMAN TKL 5.2e-84 287.9 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4YHTA 449 719 766.0 4EF:61002 Type1 Inactive DFGin 6.44 13.919 BLAminus -130.91, -175.71 59.89, 88.64 -101.88, 16.92 281.61, 73.69 -54.19, -26.07 in-in in 8.608 Saltbr-in 2.731 HRD-in -63.73, -42.35 62.62, 3.64 in-in-out SNCiio in-out ActLoopNT-in 2.881 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -6.83 APE8-dihe-in -100.18, 82.06 APE8-rot-in 287.27 APE67-dihe-in -63.55, -16.06 -74.16, -21.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.11 I543T,I544N,I551T,L706T,L716T None None XRAY 3.05 0.2 0.233 A 272 256 15 0 0 13 [[457, 716]] 1.0 4yht TKL_BRAF_HUMAN TKL 2.7e-84 288.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4YHTB 449 720 766.0 4EF:60802 Type1 Inactive DFGin 6.405 13.921 BLAminus -128.69, -172.56 54.11, 90.89 -102.92, 13.66 281.86, 71.12 -49.43, -28.96 in-in in 8.583 Saltbr-in 2.701 HRD-in -63.82, -42.99 62.91, 4.22 in-in-out SNCiio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -6.59 APE8-dihe-in -97.87, 80.96 APE8-rot-in 285.28 APE67-dihe-in -62.85, -18.47 -75.71, -20.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.034 I543T,I544N,I551T,L706T,L716T None None XRAY 3.05 0.2 0.233 B 272 258 14 0 0 12 [[457, 716]] 1.0 4yht TKL_BRAF_HUMAN TKL 2.7e-84 288.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
2FB8A 449 720 766.0 215:102 Type1 Inactive DFGin 6.49 14.247 BLAminus -146.27, -176.88 62.65, 94.56 -116.52, 20.29 274.9, 82.58 -45.53, -44.52 in-in in 8.885 Saltbr-in 2.919 HRD-in -63.2, -49.5 66.34, 11.44 in-in-out SNCiio in-out ActLoopNT-in 3.093 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 14.21 APE9-dihe-na 115.89, -169.69 APE8-dihe-in -101.37, 114.44 APE8-rot-in 279.54 APE67-dihe-in -65.73, -0.43 -52.43, -50.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.685 APE9-dist-in 5.958 None None None XRAY 2.9 0.203 0.291 A 281 259 13 0 0 13 [[457, 716]] 1.0 2fb8 TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
2FB8B 449 720 766.0 215:101 Type1 Inactive DFGin 6.479 14.148 BLAminus -111.07, -173.65 45.12, 91.89 -99.34, 30.47 289.04, 74.24 -44.77, -52.25 in-in in 8.669 Saltbr-in 3.215 HRD-in -70.79, -48.1 71.94, -5.57 in-in-out SNCiio in-out ActLoopNT-in 3.036 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnio APE10-dihe-na 999.0, 56.52 APE9-dihe-na 105.86, -135.38 APE8-dihe-in -106.43, 95.16 APE8-rot-in 246.18 APE67-dihe-in -77.85, -8.64 -35.19, -42.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.872 APE9-dist-out 6.834 None None None XRAY 2.9 0.203 0.291 B 281 259 13 0 0 13 [[457, 716]] 1.0 2fb8 TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3D4QA 448 723 766.0 SM5:1 Type1 Inactive DFGin 6.591 13.98 BLAminus -119.59, 176.85 67.73, 95.94 -114.03, 16.83 290.63, 70.02 -53.33, -35.88 in-in in 8.593 Saltbr-in 2.779 HRD-in -69.64, -42.7 65.9, 5.04 in-in-out SNCiio in-out ActLoopNT-in 2.91 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nooo APE10-dihe-na -176.28, 137.47 APE9-dihe-na -172.16, 131.15 APE8-dihe-out -92.13, -69.99 APE8-rot-in 247.02 APE67-dihe-out -57.22, -24.41 81.09, -39.44 APE12-dist-none 999.0 APE11-dist-out 15.289 APE10-dist-out 10.683 APE9-dist-out 9.333 None None None XRAY 2.8 0.216 0.25 A 307 264 12 0 0 12 [[457, 716]] 1.0 3d4q TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3D4QB 448 723 766.0 SM5:1 Type1 Inactive DFGin 6.509 13.98 BLAminus -115.72, 179.48 64.55, 97.83 -118.24, 22.87 289.99, 73.94 -51.25, -41.28 in-in in 8.536 Saltbr-in 2.839 HRD-in -70.17, -40.87 65.01, 1.27 in-in-out SNCiio in-out ActLoopNT-in 2.897 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nooo APE10-dihe-na -176.8, 137.66 APE9-dihe-na -170.57, 133.86 APE8-dihe-out -95.43, -67.47 APE8-rot-in 248.38 APE67-dihe-out -55.71, -23.19 80.91, -41.16 APE12-dist-none 999.0 APE11-dist-out 15.289 APE10-dist-out 10.69 APE9-dist-out 9.387 None None None XRAY 2.8 0.216 0.25 B 307 264 12 0 0 12 [[457, 716]] 1.0 3d4q TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3PPKA 448 723 766.0 FNI:727 Type1 Inactive DFGin 6.787 14.382 BLAminus -124.0, -178.09 61.54, 97.13 -118.14, 23.65 285.19, 77.52 -61.73, -35.13 in-in in 8.737 Saltbr-in 2.86 HRD-in -66.77, -41.36 66.1, 8.95 in-in-out SNCiio in-out ActLoopNT-in 2.934 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 99.28 APE8-dihe-in -100.64, 92.54 APE8-rot-out 47.4 APE67-dihe-in -51.11, -21.18 -88.3, -31.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.435 None None None XRAY 3.0 0.24 0.28 A 307 262 14 0 0 14 [[457, 716]] 1.0 3ppk TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3PPKB 448 723 766.0 FNI:727 Type1 Inactive DFGin 6.709 14.378 BLAminus -125.5, 174.44 62.28, 98.6 -113.07, 20.9 286.12, 77.58 -56.3, -29.42 in-in in 8.315 Saltbr-in 2.694 HRD-in -66.38, -37.05 62.53, -7.49 in-in-out SNCiio in-out ActLoopNT-in 2.888 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -30.44, 114.56 APE9-dihe-na -161.69, -112.88 APE8-dihe-in -94.17, 136.57 APE8-rot-in 283.49 APE67-dihe-in -57.1, -15.24 -108.67, -33.54 APE12-dist-none 999.0 APE11-dist-in 8.399 APE10-dist-out 11.658 APE9-dist-out 8.314 None None None XRAY 3.0 0.24 0.28 B 307 264 12 0 0 12 [[457, 716]] 1.0 3ppk TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3PRIA 448 723 766.0 FP4:727 Type1 Inactive DFGin 6.215 14.127 BLAminus -135.2, 167.28 72.88, 95.66 -113.67, 26.28 291.49, 68.16 -64.26, -12.29 in-in in 7.819 Saltbr-in 3.236 HRD-in -75.89, -45.29 67.83, 4.74 in-in-out SNCiio in-out ActLoopNT-in 2.919 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na 176.55, 160.69 APE9-dihe-na -174.14, 132.32 APE8-dihe-in -103.13, 129.4 APE8-rot-in 329.91 APE67-dihe-in -52.17, -13.03 -124.84, -28.03 APE12-dist-none 999.0 APE11-dist-out 15.441 APE10-dist-out 11.72 APE9-dist-out 9.456 None None None XRAY 3.5 0.245 0.303 A 307 264 12 0 0 12 [[457, 716]] 1.0 3pri TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3PRIB 448 723 766.0 FP4:727 Type1 Inactive DFGin 6.276 14.119 BLAminus -135.51, 166.8 73.87, 93.46 -111.51, 27.64 290.87, 67.31 -64.08, -14.39 in-in in 7.843 Saltbr-in 3.198 HRD-in -77.37, -41.63 65.39, 3.71 in-in-out SNCiio in-out ActLoopNT-in 2.926 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na 175.7, 161.19 APE9-dihe-na -175.35, 132.33 APE8-dihe-in -100.79, 127.95 APE8-rot-in 333.36 APE67-dihe-in -51.21, -11.34 -122.71, -29.84 APE12-dist-none 999.0 APE11-dist-out 15.444 APE10-dist-out 11.699 APE9-dist-out 9.43 None None None XRAY 3.5 0.245 0.303 B 307 264 12 0 0 12 [[457, 716]] 1.0 3pri TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3PSBA 448 723 766.0 SM6:1 Type1 Inactive DFGin 6.662 14.269 BLAminus -125.3, 175.18 70.16, 91.03 -111.9, 31.45 288.37, 77.4 -63.51, -33.07 in-in in 8.905 Saltbr-in 2.816 HRD-in -79.27, -40.84 66.72, 0.33 in-in-out SNCiio in-out ActLoopNT-in 2.863 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -36.93 APE8-dihe-in -106.54, 109.48 APE8-rot-out 47.62 APE67-dihe-in -64.21, -24.1 -90.91, -19.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.548 None None None XRAY 3.4 0.227 0.268 A 307 262 14 0 0 14 [[457, 716]] 1.0 3psb TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3PSBB 448 723 766.0 SM6:2 Type1 Inactive DFGin 6.454 14.334 BLAminus -122.43, 177.07 60.31, 95.43 -106.26, 23.21 282.6, 72.21 -49.54, -41.79 in-in in 8.963 Saltbr-in 2.886 HRD-in -72.06, -46.11 69.91, 7.1 in-in-out SNCiio in-out ActLoopNT-in 2.884 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -97.04, -173.46 APE9-dihe-na 154.34, -136.18 APE8-dihe-in -110.25, 135.65 APE8-rot-out 42.37 APE67-dihe-in -65.97, -15.91 -96.73, -17.75 APE12-dist-none 999.0 APE11-dist-in 8.301 APE10-dist-out 10.37 APE9-dist-out 7.559 None None None XRAY 3.4 0.227 0.268 B 307 264 12 0 0 12 [[457, 716]] 1.0 3psb TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3PSDA 448 723 766.0 SM7:1 Type1 Inactive DFGin 6.833 14.15 BLAminus -124.82, -173.12 58.04, 92.45 -113.75, 29.97 285.75, 86.06 -69.4, -23.14 in-in in 8.529 Saltbr-in 2.855 HRD-in -68.2, -46.27 67.99, 0.3 in-in-out SNCiio in-out ActLoopNT-in 3.073 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -64.61 APE8-dihe-in -100.67, 127.64 APE8-rot-out 52.84 APE67-dihe-in -68.31, -19.86 -96.93, -21.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.421 None None None XRAY 3.6 0.28 0.335 A 307 262 14 0 0 14 [[457, 716]] 1.0 3psd TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3PSDB 448 723 766.0 SM7:2 Type1 Inactive DFGin 6.685 14.142 BLAminus -119.75, -174.7 61.11, 89.79 -111.04, 26.35 285.59, 87.99 -65.63, -24.51 in-in in 8.658 Saltbr-in 2.813 HRD-in -69.49, -46.17 68.55, -0.6 in-in-out SNCiio in-out ActLoopNT-in 3.078 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -70.44, 155.68 APE9-dihe-na 171.41, -116.26 APE8-dihe-in -82.49, 133.65 APE8-rot-out 55.09 APE67-dihe-in -67.11, -16.33 -104.44, -22.29 APE12-dist-none 999.0 APE11-dist-in 8.049 APE10-dist-out 11.69 APE9-dist-out 8.401 None None None XRAY 3.6 0.28 0.335 B 307 264 12 0 0 12 [[457, 716]] 1.0 3psd TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3Q4CA 448 723 766.0 RSW:60001 Type1 Inactive DFGin 6.444 14.235 BLAminus -146.59, -170.54 63.5, 77.08 -100.12, 34.36 288.59, 75.88 -64.75, -40.97 in-in in 8.552 Saltbr-in 3.431 HRD-in -69.37, -57.8 78.74, 3.85 in-in-out SNCiio in-out ActLoopNT-in 3.139 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 83.59 APE9-dihe-na -85.67, 50.75 APE8-dihe-in -115.48, 63.75 APE8-rot-out 49.22 APE67-dihe-in -67.89, -18.46 -76.77, -7.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.574 APE9-dist-out 10.668 None None None XRAY 3.2 0.232 0.28 A 307 264 12 0 0 12 [[457, 716]] 1.0 3q4c TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4E26A 448 723 766.0 734:801 Type1 Inactive DFGin 6.548 14.259 BLAminus -123.09, -155.83 45.29, 82.31 -99.48, 28.47 287.12, 71.36 -65.78, -23.11 in-in in 8.473 Saltbr-in 3.276 HRD-in -66.92, -52.0 73.01, 1.38 in-in-out SNCiio in-out ActLoopNT-in 2.882 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na 176.82, 70.9 APE9-dihe-na -151.07, -48.08 APE8-dihe-in -102.0, 76.55 APE8-rot-out 48.66 APE67-dihe-in -58.71, -28.19 -81.89, -17.55 APE12-dist-out 6.526 APE11-dist-out 6.954 APE10-dist-out 12.284 APE9-dist-out 10.192 None None None XRAY 2.55 0.22 0.262 A 307 270 6 0 0 6 [[457, 716]] 1.0 4e26 TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7SHVA 449 721 766.0 29L:60801 Type1 Inactive DFGin 7.149 13.975 BLAminus -147.63, -169.13 58.79, 78.75 -106.95, 34.37 285.73, 83.49 -85.44, -39.06 in-in in 8.58 Saltbr-in 2.607 HRD-in -66.2, -50.26 77.35, -0.9 in-in-out SNCiio in-out ActLoopNT-in 2.912 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnio APE10-dihe-na 999.0, -52.91 APE9-dihe-na 60.55, -7.98 APE8-dihe-in -83.24, 65.36 APE8-rot-out 38.35 APE67-dihe-in -63.32, -24.58 -66.92, -44.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.959 APE9-dist-out 9.497 None None None XRAY 2.88 0.221 0.242 A 308 261 12 0 0 12 [[457, 716]] 1.0 7shv TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4MNFB 449 720 766.0 29L:801 Type1 Inactive DFGin 6.486 13.922 BLAminus -122.68, -176.93 63.73, 92.47 -110.65, 27.31 288.5, 68.83 -50.42, -45.23 in-in in 8.699 Saltbr-in 2.866 HRD-in -76.32, -52.93 74.07, 3.14 in-in-out SNCiio in-out ActLoopNT-in 3.063 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 13.12 APE8-rot-out 79.33 APE67-dihe-in -65.4, -15.67 -79.06, -24.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 V600E None None XRAY 2.802 0.215 0.275 B 329 257 15 0 0 15 [[457, 716]] 1.0 4mnf TKL_BRAF_HUMAN TKL 1.4e-81 279.9 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7MFFA 449 732 766.0 215:801 Type1 Inactive DFGin 6.36 14.742 BLAminus -112.03, -166.91 58.58, 66.73 -90.64, 30.13 276.88, 45.65 -62.65, -42.41 in-out in 9.03 Saltbr-out 4.521 HRD-in -80.55, -46.77 72.64, -3.52 out-in-out SNCoio in-out ActLoopNT-in 3.118 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -12.78 APE9-dihe-na 72.05, -150.48 APE8-dihe-in -69.83, 149.19 APE8-rot-out 174.32 APE67-dihe-in -65.5, -22.12 -103.63, -2.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.005 APE9-dist-out 9.013 None SEP365,SEP729 SEP365,SEP729 EM 3.89 999.0 999.0 A 766 271 13 0 0 13 [[457, 716]] 1.0 7mff TKL_BRAF_HUMAN TKL 1.3e-80 277.1 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7MFFB 449 733 766.0 215:801 Type1 Inactive DFGin 6.597 15.01 BLAminus -114.09, -161.38 57.73, 64.61 -99.79, 23.65 275.25, 74.28 -77.75, -48.0 in-in in 9.896 Saltbr-in 3.331 HRD-in -85.83, -46.32 64.25, 3.39 in-in-out SNCiio in-out ActLoopNT-in 3.041 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, -42.1 APE9-dihe-na 151.05, -167.76 APE8-dihe-in -113.77, 134.96 APE8-rot-out 186.35 APE67-dihe-in -104.87, -21.77 -63.7, -3.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.552 APE9-dist-in 5.872 None SEP365,SEP729 SEP365,SEP729 EM 3.89 999.0 999.0 B 766 272 13 0 0 13 [[457, 716]] 1.0 7mff TKL_BRAF_HUMAN TKL 1.3e-80 277.1 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3PPJA 448 723 766.0 FOI:727 Type1.5_Back Inactive DFGin 6.512 14.144 BLAminus -118.68, 162.14 70.52, 93.12 -108.75, 36.02 292.03, 61.87 -65.84, -21.38 in-in in 8.592 Saltbr-in 2.735 HRD-in -81.51, -38.2 60.89, 6.44 in-in-out SNCiio in-out ActLoopNT-in 2.903 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -75.6 APE8-dihe-in -107.01, 122.44 APE8-rot-in 355.7 APE67-dihe-in -62.87, -11.96 -106.79, -22.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.701 None None None XRAY 3.7 0.251 0.272 A 307 262 14 0 0 14 [[457, 716]] 1.0 3ppj TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3PPJB 448 723 766.0 FOI:727 Type1.5_Back Inactive DFGin 6.498 14.158 BLAminus -117.7, 161.15 71.69, 92.42 -107.49, 34.88 292.55, 61.48 -64.16, -21.41 in-in in 8.599 Saltbr-in 2.762 HRD-in -81.58, -39.05 61.66, 5.65 in-in-out SNCiio in-out ActLoopNT-in 2.899 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -45.39, 125.84 APE9-dihe-na -167.47, -85.86 APE8-dihe-in -107.52, 124.34 APE8-rot-in 353.86 APE67-dihe-in -62.54, -12.0 -107.16, -21.64 APE12-dist-none 999.0 APE11-dist-in 8.478 APE10-dist-out 11.708 APE9-dist-out 8.628 None None None XRAY 3.7 0.251 0.272 B 307 264 12 0 0 12 [[457, 716]] 1.0 3ppj TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7SHVB 449 721 766.0 29L:60801 Type1.5_Back Inactive DFGin 6.736 14.171 BLAminus -147.31, -168.46 59.95, 68.87 -90.82, 20.67 284.09, 50.14 -57.74, -56.04 in-in in 8.771 Saltbr-in 2.802 HRD-in -76.59, -37.99 67.86, -2.2 in-in-out SNCiio in-out ActLoopNT-in 2.859 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnio APE10-dihe-na 999.0, -136.62 APE9-dihe-na -141.24, 15.82 APE8-dihe-in -103.28, 75.96 APE8-rot-in 280.52 APE67-dihe-in -56.94, -26.52 -73.16, -41.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.391 APE9-dist-out 9.402 None None None XRAY 2.88 0.221 0.242 B 308 262 11 0 0 11 [[457, 716]] 1.0 7shv TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5JSMA 448 721 766.0 No_ligand No_ligand Inactive DFGin 6.391 13.039 BLAplus -138.4, -174.44 69.43, 19.37 -96.67, -11.2 60.48, 90.73 -70.16, 170.4 out-out out 12.519 Saltbr-out 11.848 HRD-in -67.42, -52.76 81.37, -8.85 out-out-out SNCooo out-out ActLoopNT-out 7.37 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -126.49 APE9-dihe-na -72.61, -3.43 APE8-dihe-out -78.38, -5.15 APE8-rot-in 323.72 APE67-dihe-in -63.19, -24.3 -66.02, -22.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.021 APE9-dist-out 11.751 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.19 0.209 0.26 A 280 262 12 0 0 12 [[457, 716]] 1.0 5jsm TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5JSMD 448 721 766.0 No_ligand No_ligand Inactive DFGin 6.123 13.031 BLAplus -131.14, -174.1 61.1, 20.52 -90.6, -7.92 60.52, 88.06 -77.98, 170.41 out-out out 12.232 Saltbr-out 11.469 HRD-in -70.97, -49.77 79.36, -15.05 out-out-out SNCooo out-out ActLoopNT-out 6.931 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -122.39 APE9-dihe-na -69.86, -160.53 APE8-dihe-out 66.03, 26.93 APE8-rot-out 79.84 APE67-dihe-in -63.53, -17.75 -74.4, -20.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.286 APE9-dist-out 11.499 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.19 0.209 0.26 D 280 255 19 0 0 11 [[457, 716]] 1.0 5jsm TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5JT2B 448 719 766.0 No_ligand No_ligand Inactive DFGin 6.475 13.127 BLAplus -132.05, -178.42 60.44, 26.71 -91.43, -16.34 56.91, 94.97 -75.01, 161.8 out-out out 12.667 Saltbr-out 10.981 HRD-in -71.51, -55.74 82.51, -8.57 out-out-out SNCooo out-out ActLoopNT-out 7.395 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -9.45 APE8-rot-out 58.42 APE67-dihe-in -62.61, -14.07 -74.77, -25.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.702 0.216 0.273 B 280 250 22 0 0 16 [[457, 716]] 1.0 5jt2 TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5JT2D 448 718 766.0 No_ligand No_ligand Inactive DFGin 6.579 13.39 BLAplus -136.04, -175.12 61.39, 23.06 -96.39, -13.73 60.15, 86.19 -72.12, 160.9 out-out out 12.512 Saltbr-out 11.095 HRD-in -68.92, -57.27 83.18, -10.11 out-out-out SNCooo out-out ActLoopNT-out 7.019 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -2.9 APE8-rot-out 210.05 APE67-dihe-in -67.61, -13.98 -75.83, -31.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.702 0.216 0.273 D 280 232 39 0 0 15 [[457, 716]] 1.0 5jt2 TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6UANB 449 750 766.0 No_ligand No_ligand Inactive DFGin 6.087 12.636 BLAplus -154.71, 179.74 58.46, 43.55 -98.79, 69.87 37.99, 91.03 -71.09, -56.22 in-out in 9.594 Saltbr-out 7.483 HRD-in -73.07, -51.77 71.88, -8.56 out-in-none SNCoin in-none ActLoopNT-in 3.233 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T373C,I374M SEP729 SEP729 EM 3.9 999.0 999.0 B 768 261 41 0 0 21 [[457, 716]] 1.0 6uan TKL_BRAF_HUMAN TKL 1.3e-80 277.1 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
9BFBA 448 721 766.0 A1AN9:803 Type1 Inactive DFGin 5.324 13.571 BLAplus -126.78, -169.92 68.06, 26.72 -98.4, -4.13 57.41, 91.95 -79.05, 165.15 out-out out 12.668 Saltbr-out 12.074 HRD-in -66.55, -53.43 79.05, -12.09 out-out-out SNCooo out-out ActLoopNT-out 8.862 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -57.65, -38.69 APE9-dihe-na -78.55, -14.23 APE8-dihe-out -117.57, -4.84 APE8-rot-out 65.23 APE67-dihe-in -63.24, -28.07 -55.27, -36.67 APE12-dist-in 12.058 APE11-dist-out 16.695 APE10-dist-out 19.29 APE9-dist-out 10.837 F667A,R671A,Y673A None None XRAY 1.92 0.166 0.189 A 294 272 2 0 0 0 [[457, 716]] 1.0 9bfb TKL_BRAF_HUMAN TKL 1e-81 280.4 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
9BP8A 449 721 766.0 A1AQY:801 Type1 Inactive DFGin 5.22 13.557 BLAplus -129.41, -173.26 66.62, 35.11 -102.57, -8.15 57.04, 89.1 -72.95, 156.71 out-out out 13.126 Saltbr-out 11.44 HRD-in -67.37, -53.21 82.55, -13.02 out-out-out SNCooo out-out ActLoopNT-out 9.031 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -60.62, -35.92 APE9-dihe-na -79.61, -15.25 APE8-dihe-out -112.44, -12.93 APE8-rot-in 291.55 APE67-dihe-in -61.23, -28.38 -53.66, -40.13 APE12-dist-in 11.885 APE11-dist-out 16.59 APE10-dist-out 19.005 APE9-dist-out 10.527 F667A,R671A,Y673A None None XRAY 1.73 0.166 0.193 A 294 273 0 0 0 0 [[457, 716]] 1.0 9bp8 TKL_BRAF_HUMAN TKL 1e-81 280.4 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5FD2B 449 720 766.0 5XJ:801 Type1 Inactive DFGin 6.515 12.754 BLAplus -160.33, 172.82 88.44, 33.77 -112.02, 12.86 60.15, 87.86 -69.02, 999.0 out-none out 11.96 Saltbr-none 999.0 HRD-in -57.39, -37.56 64.99, -12.71 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 171.99 APE9-dihe-na -126.99, 19.84 APE8-dihe-in -138.9, 57.46 APE8-rot-in 290.89 APE67-dihe-in -57.69, -25.53 -71.85, -27.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.999 None None None XRAY 2.89 0.216 0.278 B 300 234 38 0 0 17 [[457, 716]] 1.0 5fd2 TKL_BRAF_HUMAN TKL 1e-81 280.4 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3SKCB 448 723 766.0 BR2:801 Type1 Inactive DFGin 5.463 14.203 BLAplus -135.93, 171.09 86.44, 39.5 -114.85, -0.83 58.51, 73.54 -75.68, 174.8 out-out out 11.35 Saltbr-out 11.059 HRD-in -71.95, -50.11 76.71, 2.16 out-out-out SNCooo out-out ActLoopNT-out 8.683 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -168.63, -26.01 APE9-dihe-na -100.89, 7.04 APE8-dihe-out -156.0, 39.42 APE8-rot-out 37.87 APE67-dihe-in -67.54, -21.27 -78.88, -19.35 APE12-dist-in 11.09 APE11-dist-out 14.619 APE10-dist-out 17.407 APE9-dist-out 10.328 None None None XRAY 3.2 0.235 0.271 B 307 276 0 0 0 0 [[457, 716]] 1.0 3skc TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
8VYUA 235 738 766.0 A1AEN:801 Type1 Inactive DFGin 7.167 13.275 BLAplus -117.18, -150.85 59.81, 31.27 -110.17, 13.73 54.05, 90.61 -85.24, -171.83 out-out out 13.497 Saltbr-out 10.409 HRD-out -111.09, 143.69 -109.47, -35.63 out-out-none SNCoon out-none ActLoopNT-out 10.157 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP365,SEP729 SEP365,SEP729 EM 4.07 999.0 999.0 A 767 290 58 0 0 22 [[457, 716]] 1.0 8vyu TKL_BRAF_HUMAN TKL 2.8e-81 279.2 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4CQEA 449 720 766.0 CQE:1721 Type1.5_Back Inactive DFGin 5.478 13.664 BLAplus -125.88, -177.56 65.78, 47.02 -122.69, 7.58 61.31, 87.06 -91.72, 999.0 out-out out 10.982 Saltbr-out 5.484 HRD-in -68.23, -53.22 84.59, -16.79 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -19.36 APE8-dihe-out -111.66, 7.78 APE8-rot-in 306.87 APE67-dihe-in -63.32, -25.17 -66.28, -32.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.467 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.3 0.21 0.255 A 278 250 22 0 0 18 [[457, 716]] 1.0 4cqe TKL_BRAF_HUMAN TKL 4.5e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5JRQA 448 719 766.0 6N9:60801 Type1.5_Back Inactive DFGin 6.383 12.701 BLAplus -128.11, -173.12 63.43, 15.29 -89.17, -1.57 61.53, 90.6 -61.67, 159.33 out-out out 12.012 Saltbr-out 11.509 HRD-in -71.32, -62.23 83.15, -16.2 out-out-none SNCoon out-none ActLoopNT-out 6.585 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -5.1 APE8-rot-in 271.28 APE67-dihe-in -63.55, -24.37 -59.37, -34.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.287 0.2 0.254 A 280 257 15 0 0 12 [[457, 716]] 1.0 5jrq TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5JRQB 448 720 766.0 6N9:60801 Type1.5_Back Inactive DFGin 6.17 12.698 BLAplus -133.12, -173.75 67.64, 13.36 -87.31, -1.91 62.04, 89.76 -64.01, 169.14 out-out out 12.002 Saltbr-out 11.845 HRD-in -80.28, -50.19 74.7, -17.58 out-out-none SNCoon out-none ActLoopNT-out 6.658 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -66.56, -23.24 999.0, -42.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.287 0.2 0.254 B 280 245 28 0 0 16 [[457, 716]] 1.0 5jrq TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5JSMB 448 721 766.0 6NB:60801 Type1.5_Back Inactive DFGin 6.062 13.115 BLAplus -131.27, -176.98 63.39, 23.33 -93.63, -10.63 60.2, 91.2 -76.07, 171.28 out-out out 12.226 Saltbr-out 11.076 HRD-in -71.71, -49.86 78.57, -16.34 out-out-none SNCoon out-none ActLoopNT-out 6.866 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 9.89 APE8-rot-in 315.15 APE67-dihe-in -61.71, -26.31 -77.16, -23.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.19 0.209 0.26 B 280 259 15 0 0 12 [[457, 716]] 1.0 5jsm TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5JSMC 448 722 766.0 6NB:60801 Type1.5_Back Inactive DFGin 6.383 13.11 BLAplus -129.7, -173.18 63.38, 21.31 -96.67, -12.5 57.76, 93.77 -77.13, 167.54 out-out out 12.637 Saltbr-out 11.85 HRD-in -70.95, -49.33 78.01, -16.99 out-out-out SNCooo out-out ActLoopNT-out 6.854 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 9.67 APE8-rot-out 63.05 APE67-dihe-in -58.68, -22.16 -80.83, -26.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.19 0.209 0.26 C 280 259 16 0 0 15 [[457, 716]] 1.0 5jsm TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5JT2A 448 719 766.0 6NC:60802 Type1.5_Back Inactive DFGin 6.222 12.912 BLAplus -131.83, -179.76 60.44, 27.47 -91.8, -15.26 60.84, 91.27 -76.03, 163.63 out-out out 12.161 Saltbr-out 10.863 HRD-in -68.55, -55.07 79.46, -6.74 out-out-out SNCooo out-out ActLoopNT-out 6.973 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -10.99 APE8-rot-out 59.11 APE67-dihe-in -63.98, -11.05 -84.27, -24.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.702 0.216 0.273 A 280 253 19 0 0 11 [[457, 716]] 1.0 5jt2 TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5JT2C 448 719 766.0 6NC:60801 Type1.5_Back Inactive DFGin 6.266 13.213 BLAplus -132.63, 179.4 60.59, 25.36 -92.03, -16.73 59.91, 87.97 -73.39, 163.09 out-out out 12.305 Saltbr-out 11.076 HRD-in -70.05, -56.98 80.65, -10.11 out-out-out SNCooo out-out ActLoopNT-out 6.95 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -13.76 APE8-rot-out 58.86 APE67-dihe-in -62.78, -11.84 -84.22, -24.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.702 0.216 0.273 C 280 247 25 0 0 12 [[457, 716]] 1.0 5jt2 TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4RZVA 449 721 766.0 032:801 Type1.5_Back Inactive DFGin 6.623 12.87 BLAplus -130.91, -172.9 60.6, 24.8 -98.53, -10.69 57.76, 91.05 -69.22, 172.66 out-out out 12.644 Saltbr-out 10.258 HRD-in -67.58, -51.33 73.51, -5.96 out-out-out SNCooo out-out ActLoopNT-out 7.109 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -135.17, 121.31 APE9-dihe-na -132.69, 47.25 APE8-dihe-in -116.19, 105.13 APE8-rot-in 306.78 APE67-dihe-in -65.92, -31.75 -100.96, -1.47 APE12-dist-none 999.0 APE11-dist-in 13.566 APE10-dist-out 15.169 APE9-dist-out 10.302 R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.994 0.207 0.267 A 281 261 12 0 0 12 [[457, 716]] 1.0 4rzv TKL_BRAF_HUMAN TKL 7.2e-84 287.4 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4RZVB 449 722 766.0 032:801 Type1.5_Back Inactive DFGin 6.47 12.835 BLAplus -121.2, 178.65 56.71, 36.71 -99.28, -19.01 59.27, 87.57 -68.87, 172.54 out-out out 12.328 Saltbr-out 11.67 HRD-in -71.84, -50.61 63.03, 10.44 out-out-out SNCooo out-out ActLoopNT-out 6.743 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -82.65, 28.28 APE9-dihe-na -100.48, -28.28 APE8-dihe-in -136.49, 95.01 APE8-rot-in 296.61 APE67-dihe-in -55.46, -18.41 -85.27, -21.3 APE12-dist-in 13.178 APE11-dist-in 13.816 APE10-dist-out 18.847 APE9-dist-out 11.166 R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.994 0.207 0.267 B 281 271 3 0 0 0 [[457, 716]] 1.0 4rzv TKL_BRAF_HUMAN TKL 7.2e-84 287.4 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4XV1A 449 705 766.0 904:60801 Type1.5_Back Inactive DFGin 5.265 13.518 BLAplus -126.0, -170.09 68.06, 24.34 -98.7, -10.99 52.38, 90.09 -65.7, 999.0 out-out out 11.078 Saltbr-out 8.082 HRD-in -65.2, -48.41 74.87, -5.74 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, -52.0 APE9-dihe-na -137.15, 170.54 APE8-dihe-in -90.29, 107.37 APE8-rot-out 51.85 APE67-dihe-in -59.87, -29.31 -94.54, -12.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.673 S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R None None XRAY 2.47 0.236 0.273 A 292 228 29 0 0 17 [[457, 716]] 1.0 4xv1 TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4XV3A 448 705 766.0 P02:60801 Type1.5_Back Inactive DFGin 5.531 13.402 BLAplus -134.46, -171.77 61.26, 48.36 -114.54, -11.83 46.72, 87.81 -64.98, 999.0 out-out out 11.101 Saltbr-out 10.159 HRD-in -61.64, -42.75 69.87, -4.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 19.55 APE9-dihe-na -138.7, -116.01 APE8-dihe-in -79.73, 110.93 APE8-rot-out 50.96 APE67-dihe-in -61.23, -22.36 -102.85, -13.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.336 S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R None None XRAY 2.8 0.26 0.296 A 292 232 26 0 0 17 [[457, 716]] 1.0 4xv3 TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4FK3A 448 718 766.0 325:801 Type1.5_Back Inactive DFGin 5.366 13.695 BLAplus -133.88, -167.56 58.89, 45.8 -124.05, 12.28 65.31, 91.87 -122.04, 999.0 out-out out 11.004 Saltbr-out 9.73 HRD-in -61.94, -44.69 76.48, -14.73 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 26.64 APE9-dihe-na -141.77, -157.8 APE8-dihe-in -80.67, 92.47 APE8-rot-in 332.2 APE67-dihe-in -66.02, -29.09 -81.79, -14.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.34 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.65 0.262 0.315 A 292 251 20 0 0 17 [[457, 716]] 1.0 4fk3 TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6UUOB 448 721 766.0 QH1:801 Type1.5_Back Inactive DFGin 5.804 13.272 BLAplus -152.6, -159.47 58.51, 46.15 -126.1, 28.18 55.52, 85.25 -102.19, 999.0 out-out out 11.675 Saltbr-out 8.592 HRD-out -75.28, 102.15 -78.85, -32.66 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 145.23 APE8-dihe-out -88.62, 38.26 APE8-rot-out 65.25 APE67-dihe-in -65.54, -37.74 -66.97, -36.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 22.994 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.288 0.265 0.288 B 284 252 22 0 0 18 [[457, 716]] 1.0 6uuo TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5ITAA 448 718 766.0 6DC:801 Type1.5_Back Inactive DFGin 5.055 13.46 BLAplus -120.12, -172.98 68.68, 46.04 -122.35, 5.81 57.91, 88.28 -59.19, -177.17 out-out out 10.684 Saltbr-out 5.233 HRD-in -60.95, -54.03 78.17, -8.74 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -164.16 APE8-rot-in 278.34 APE67-dihe-in -68.96, -22.68 -78.66, -20.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 1.95 0.197 0.244 A 297 250 21 0 0 18 [[457, 716]] 1.0 5ita TKL_BRAF_HUMAN TKL 5.7e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4WO5A 448 721 766.0 324:801 Type1.5_Back Inactive DFGin 6.197 12.471 BLAplus -113.39, 171.89 60.4, 25.87 -88.62, -20.81 62.14, 83.22 -76.85, 162.27 out-out out 11.855 Saltbr-out 10.947 HRD-in -61.99, -45.91 75.82, -24.69 out-out-out SNCooo out-out ActLoopNT-out 6.802 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iooo APE10-dihe-na -106.86, 132.67 APE9-dihe-na -94.97, 98.91 APE8-dihe-out -154.69, -103.68 APE8-rot-out 172.98 APE67-dihe-out -59.88, -33.44 59.76, -29.06 APE12-dist-in 13.661 APE11-dist-out 17.614 APE10-dist-out 20.645 APE9-dist-out 12.338 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.83 0.196 0.26 A 300 266 8 0 0 4 [[457, 716]] 1.0 4wo5 TKL_BRAF_HUMAN TKL 5.9e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4WO5B 450 721 766.0 324:801 Type1.5_Back Inactive DFGin 6.888 12.867 BLAplus -140.91, 168.85 84.0, 47.56 -114.71, 82.32 38.72, 99.17 -44.17, -77.3 out-none out 11.966 Saltbr-none 999.0 HRD-in -57.15, -60.67 87.46, -19.9 none-out-out SNCnoo out-out ActLoopNT-out 9.245 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -63.37 APE8-dihe-in -130.43, 79.93 APE8-rot-in 273.2 APE67-dihe-in -55.15, -30.0 -52.46, -34.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.189 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.83 0.196 0.26 B 300 257 15 0 0 15 [[457, 716]] 1.0 4wo5 TKL_BRAF_HUMAN TKL 5.9e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3OG7A 449 720 766.0 032:1 Type1.5_Back Inactive DFGin 5.36 13.446 BLAplus -137.59, -179.01 76.97, 18.21 -89.25, -11.03 54.09, 93.51 -42.45, 999.0 out-out out 11.242 Saltbr-out 8.406 HRD-in -57.13, -46.63 78.91, -15.01 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -115.54 APE8-dihe-in -81.75, 114.02 APE8-rot-out 53.56 APE67-dihe-in -69.21, -23.46 -108.29, -5.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.262 K522A,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 2.45 0.214 0.258 A 289 247 25 0 0 18 [[457, 716]] 1.0 3og7 TKL_BRAF_HUMAN TKL 1.2e-83 286.6 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4EHGA 448 723 766.0 RI9:801 Type1.5_Back Inactive DFGin 5.855 13.82 BLAplus -113.94, 175.52 73.83, 70.69 -143.13, -9.0 47.54, 75.61 -62.53, 153.47 out-out out 11.628 Saltbr-out 10.57 HRD-in -82.57, -33.1 63.93, -24.44 out-out-out SNCooo out-out ActLoopNT-out 7.414 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -27.9 APE8-dihe-in -157.45, 120.42 APE8-rot-out 42.51 APE67-dihe-in -59.0, -29.49 -117.63, -12.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.335 V600E None None XRAY 3.5 0.215 0.27 A 307 262 14 0 0 14 [[457, 716]] 1.0 4ehg TKL_BRAF_HUMAN TKL 1.1e-81 280.2 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4EHGB 448 723 766.0 RI9:801 Type1.5_Back Inactive DFGin 5.267 13.707 BLAplus -134.99, -176.48 67.9, 27.36 -89.31, -32.37 52.05, 105.83 -56.04, 153.23 out-out out 11.602 Saltbr-out 10.458 HRD-in -79.82, -38.1 68.62, -6.56 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -131.11 APE9-dihe-na -82.46, 60.2 APE8-dihe-in -164.62, 72.39 APE8-rot-out 68.9 APE67-dihe-in -59.85, -21.12 -109.92, -9.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.596 APE9-dist-out 11.826 V600E None None XRAY 3.5 0.215 0.27 B 307 260 16 0 0 16 [[457, 716]] 1.0 4ehg TKL_BRAF_HUMAN TKL 1.1e-81 280.2 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5FD2A 448 720 766.0 5XJ:801 Type1.5_Back Inactive DFGin 5.671 13.483 BLAplus -131.37, -172.89 52.29, 39.93 -105.53, -8.5 56.1, 88.04 -63.55, 167.18 out-out out 12.509 Saltbr-out 10.07 HRD-in -66.35, -44.8 69.83, -6.15 out-out-out SNCooo out-out ActLoopNT-out 7.746 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -37.28 APE9-dihe-na -133.55, 43.79 APE8-dihe-out -129.77, 15.23 APE8-rot-in 311.9 APE67-dihe-in -66.32, -26.35 -70.67, -25.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.448 APE9-dist-out 10.545 None None None XRAY 2.89 0.216 0.278 A 300 264 9 0 0 9 [[457, 716]] 1.0 5fd2 TKL_BRAF_HUMAN TKL 1e-81 280.4 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3TV4A 448 723 766.0 TV4:1 Type1.5_Back Inactive DFGin 5.402 13.697 BLAplus -142.83, -171.49 46.74, 47.2 -119.19, -6.43 69.26, 117.52 -75.58, 165.81 out-out out 12.033 Saltbr-out 11.313 HRD-in -68.61, -47.44 76.91, -23.27 out-out-out SNCooo out-out ActLoopNT-out 9.064 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -82.49 APE9-dihe-na -79.94, 51.24 APE8-dihe-out -152.88, 1.97 APE8-rot-in 289.52 APE67-dihe-in -59.4, -38.95 -39.48, -42.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.881 APE9-dist-out 10.479 None None None XRAY 3.4 0.244 0.307 A 307 264 12 0 0 10 [[457, 716]] 1.0 3tv4 TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3TV4B 448 723 766.0 TV4:1 Type1.5_Back Inactive DFGin 5.453 13.695 BLAplus -121.56, -159.18 14.55, 74.26 -129.62, -2.38 64.64, 122.32 -64.07, -82.37 out-out out 11.627 Saltbr-out 10.593 HRD-in -79.62, -54.84 87.21, -27.02 out-out-out SNCooo out-out ActLoopNT-out 8.571 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -77.3, -34.85 APE9-dihe-na -85.7, 48.56 APE8-dihe-out -160.1, -10.48 APE8-rot-in 291.93 APE67-dihe-in -59.37, -49.79 -52.97, -39.23 APE12-dist-in 10.775 APE11-dist-out 14.274 APE10-dist-out 17.99 APE9-dist-out 10.256 None None None XRAY 3.4 0.244 0.307 B 307 276 0 0 0 0 [[457, 716]] 1.0 3tv4 TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3TV6A 448 723 766.0 B0R:1 Type1.5_Back Inactive DFGin 5.276 13.377 BLAplus -121.97, -177.73 69.22, 15.6 -85.44, -8.43 61.04, 102.69 -77.52, 161.68 out-out out 11.947 Saltbr-out 10.65 HRD-out -67.75, -47.34 58.38, 69.46 out-out-out SNCooo out-out ActLoopNT-out 8.407 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 132.99 APE9-dihe-na 61.12, -175.64 APE8-dihe-out 54.5, 0.69 APE8-rot-in 303.6 APE67-dihe-in -61.66, -28.98 -65.54, -27.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.017 APE9-dist-out 11.525 None None None XRAY 3.3 0.24 0.288 A 307 268 8 0 0 8 [[457, 716]] 1.0 3tv6 TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3TV6B 448 723 766.0 B0R:1 Type1.5_Back Inactive DFGin 5.502 13.843 BLAplus -125.08, -169.86 55.0, 38.89 -104.29, -19.25 56.18, 93.9 -40.71, -81.07 out-out out 11.869 Saltbr-out 10.492 HRD-in -64.31, -49.25 75.66, -4.37 out-out-out SNCooo out-out ActLoopNT-out 8.382 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -72.44, -33.04 APE9-dihe-na -83.46, 25.61 APE8-dihe-out -151.0, 10.45 APE8-rot-in 297.95 APE67-dihe-in -66.52, -19.91 -69.09, -32.84 APE12-dist-in 11.217 APE11-dist-out 14.75 APE10-dist-out 18.32 APE9-dist-out 10.404 None None None XRAY 3.3 0.24 0.288 B 307 276 0 0 0 0 [[457, 716]] 1.0 3tv6 TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4E4XA 448 721 766.0 T1Q:801 Type1.5_Back Inactive DFGin 5.415 13.363 BLAplus -131.88, 173.14 75.18, 30.58 -101.82, -10.02 55.81, 83.67 -117.53, 134.84 out-out out 11.598 Saltbr-out 10.556 HRD-in -63.36, -55.37 84.27, -20.39 out-out-out SNCooo out-out ActLoopNT-out 8.693 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -122.89, -73.39 APE9-dihe-na -70.95, 32.47 APE8-dihe-out -146.48, 22.51 APE8-rot-out 45.91 APE67-dihe-in -65.86, -22.59 -84.31, -22.16 APE12-dist-none 999.0 APE11-dist-out 14.616 APE10-dist-out 18.31 APE9-dist-out 11.183 None None None XRAY 3.6 0.275 0.315 A 307 267 7 0 0 7 [[457, 716]] 1.0 4e4x TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4E4XB 448 721 766.0 T1Q:801 Type1.5_Back Inactive DFGin 5.416 13.351 BLAplus -132.24, 173.33 74.51, 29.59 -99.47, -9.48 56.23, 83.84 -121.9, 128.32 out-out out 11.602 Saltbr-out 10.548 HRD-in -63.26, -55.6 84.82, -20.39 out-out-out SNCooo out-out ActLoopNT-out 8.694 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -123.17, -73.01 APE9-dihe-na -71.52, 32.88 APE8-dihe-out -146.5, 22.32 APE8-rot-out 45.55 APE67-dihe-in -65.69, -23.22 -84.43, -21.74 APE12-dist-in 11.291 APE11-dist-out 14.588 APE10-dist-out 18.297 APE9-dist-out 11.19 None None None XRAY 3.6 0.275 0.315 B 307 274 0 0 0 0 [[457, 716]] 1.0 4e4x TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4EHEA 448 723 766.0 RI8:801 Type1.5_Back Inactive DFGin 5.048 13.184 BLAplus -125.98, -178.47 62.84, 29.19 -94.42, -4.71 59.77, 96.5 -101.0, 165.52 out-out out 11.944 Saltbr-out 10.778 HRD-in -64.88, -47.02 61.07, 32.78 out-out-out SNCooo out-out ActLoopNT-out 8.737 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 118.03 APE9-dihe-na 87.24, 14.12 APE8-dihe-out -132.26, 44.88 APE8-rot-out 37.19 APE67-dihe-in -55.75, -26.88 -67.03, -34.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.019 APE9-dist-out 11.158 None None None XRAY 3.3 0.228 0.296 A 307 266 10 0 0 10 [[457, 716]] 1.0 4ehe TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4EHEB 448 723 766.0 RI8:801 Type1.5_Back Inactive DFGin 5.529 13.841 BLAplus -127.25, -168.5 56.47, 32.77 -102.51, 8.59 61.37, 88.08 -68.29, -97.55 out-out out 11.86 Saltbr-out 11.0 HRD-in -73.09, -51.91 79.83, -18.55 out-out-out SNCooo out-out ActLoopNT-out 8.714 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -63.16, -31.12 APE9-dihe-na -64.6, -10.1 APE8-dihe-out -150.53, 33.92 APE8-rot-out 19.79 APE67-dihe-in -56.94, -33.52 -58.48, -40.21 APE12-dist-in 11.294 APE11-dist-out 14.993 APE10-dist-out 18.447 APE9-dist-out 10.035 None None None XRAY 3.3 0.228 0.296 B 307 276 0 0 0 0 [[457, 716]] 1.0 4ehe TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4PP7A 448 721 766.0 2VX:801 Type1.5_Back Inactive DFGin 5.063 13.55 BLAplus -144.36, -179.4 70.84, 11.79 -79.39, -18.32 64.06, 95.8 -64.87, 163.13 out-out out 11.819 Saltbr-out 9.898 HRD-in -60.94, -49.15 74.91, 0.91 out-out-out SNCooo out-out ActLoopNT-out 8.882 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -161.63, 37.41 APE9-dihe-na -160.85, -8.39 APE8-dihe-out -110.61, 12.59 APE8-rot-in 299.45 APE67-dihe-in -61.85, -28.03 -37.74, -49.88 APE12-dist-none 999.0 APE11-dist-out 14.074 APE10-dist-out 17.73 APE9-dist-out 10.587 None None None XRAY 3.4 0.198 0.254 A 307 267 7 0 0 7 [[457, 716]] 1.0 4pp7 TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4PP7B 448 721 766.0 2VX:801 Type1.5_Back Inactive DFGin 5.575 13.855 BLAplus -143.27, -178.26 56.82, 45.93 -107.94, -13.37 54.78, 79.55 -65.66, 171.36 out-out out 11.418 Saltbr-out 10.581 HRD-in -65.31, -43.62 75.45, -24.33 out-out-out SNCooo out-out ActLoopNT-out 8.573 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -59.94, -29.73 APE9-dihe-na -89.39, 13.82 APE8-dihe-out -141.1, 5.05 APE8-rot-in 299.07 APE67-dihe-in -66.69, -31.17 -60.83, -30.61 APE12-dist-in 11.426 APE11-dist-out 15.016 APE10-dist-out 18.533 APE9-dist-out 10.452 None None None XRAY 3.4 0.198 0.254 B 307 274 0 0 0 0 [[457, 716]] 1.0 4pp7 TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
8VYSA 235 738 766.0 A1AEN:801 Type1.5_Back Inactive DFGin 6.682 13.203 BLAplus -142.03, -178.59 74.92, 8.76 -86.61, -7.69 62.8, 83.25 -71.31, -163.31 out-out out 11.734 Saltbr-out 10.677 HRD-out -77.69, 104.1 -73.86, -30.17 out-out-out SNCooo out-out ActLoopNT-out 9.159 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 7.34 APE8-dihe-out -101.13, 17.39 APE8-rot-out 182.67 APE67-dihe-in -57.56, -44.9 -61.0, -42.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.066 V600E SEP365,SEP729 SEP365,SEP729 EM 3.06 999.0 999.0 A 767 311 38 0 0 13 [[457, 716]] 1.0 8vys TKL_BRAF_HUMAN TKL 2.9e-81 279.2 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3SKCA 448 723 766.0 BR2:801 Type1 Inactive DFGin 6.265 14.373 BLBminus -140.28, 169.02 94.82, 74.85 -82.48, -134.09 285.7, 0.62 -102.42, 999.0 out-out out 11.319 Saltbr-out 11.094 HRD-in -72.66, -48.6 73.69, 2.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -166.13, -26.66 APE9-dihe-na -100.41, 9.29 APE8-dihe-out -157.77, 40.44 APE8-rot-out 36.63 APE67-dihe-in -70.95, -19.94 -78.93, -17.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.339 None None None XRAY 3.2 0.235 0.271 A 307 260 16 0 0 16 [[457, 716]] 1.0 3skc TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4E26B 448 722 766.0 734:801 Type1 Inactive DFGin 6.361 14.26 BLBminus -129.24, -167.87 46.52, 96.15 -111.58, -138.63 293.59, 65.8 80.77, -62.67 in-in in 8.043 Saltbr-in 3.038 HRD-in -58.73, -54.71 74.73, 10.01 in-in-out SNCiio in-out ActLoopNT-in 2.844 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -177.61 APE9-dihe-na -153.13, 152.76 APE8-dihe-out -144.56, 37.84 APE8-rot-in 294.76 APE67-dihe-in -56.79, -31.94 -61.82, -28.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.722 APE9-dist-out 10.434 None None None XRAY 2.55 0.22 0.262 B 307 264 11 0 0 11 [[457, 716]] 1.0 4e26 TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5HIEA 449 722 766.0 P06:801 Type1 Inactive DFGin 8.929 14.448 BLBminus -141.8, -164.77 53.26, 57.86 -65.92, 138.13 285.18, 76.08 -69.2, 130.11 out-out out 15.725 Saltbr-out 12.5 HRD-in -60.62, -46.76 71.26, -9.44 out-out-out SNCooo out-out ActLoopNT-out 12.738 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 143.17 APE8-dihe-in -83.81, 99.59 APE8-rot-in 302.38 APE67-dihe-in -53.53, -27.96 -85.37, -23.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.176 None None None XRAY 3.0 0.196 0.221 A 302 258 11 0 0 11 [[457, 716]] 1.0 5hie TKL_BRAF_HUMAN TKL 5.8e-80 274.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5HIEB 449 722 766.0 P06:801 Type1 Inactive DFGin 9.077 14.341 BLBminus -142.86, -164.65 53.45, 58.39 -66.51, 138.76 285.5, 75.66 -69.99, 128.6 out-out out 16.44 Saltbr-out 12.325 HRD-in -61.23, -46.57 70.13, -7.74 out-out-out SNCooo out-out ActLoopNT-out 12.525 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 61.11 APE9-dihe-na -158.28, 177.47 APE8-dihe-in -84.39, 102.56 APE8-rot-in 300.94 APE67-dihe-in -53.91, -28.83 -85.61, -22.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.135 APE9-dist-out 9.836 None None None XRAY 3.0 0.196 0.221 B 302 259 10 0 0 10 [[457, 716]] 1.0 5hie TKL_BRAF_HUMAN TKL 5.8e-80 274.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5HIEC 449 722 766.0 P06:801 Type1 Inactive DFGin 10.205 14.448 BLBminus -142.24, -163.89 53.8, 57.5 -66.04, 139.53 285.14, 75.68 -75.41, 148.8 out-out out 16.307 Saltbr-out 11.857 HRD-in -60.99, -45.77 71.53, -8.16 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 139.61 APE9-dihe-na 88.59, -130.66 APE8-dihe-in -113.06, 104.87 APE8-rot-in 299.6 APE67-dihe-in -52.68, -29.4 -86.36, -21.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.111 APE9-dist-out 10.018 None None None XRAY 3.0 0.196 0.221 C 302 253 16 0 0 16 [[457, 716]] 1.0 5hie TKL_BRAF_HUMAN TKL 5.8e-80 274.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5HIED 449 722 766.0 P06:801 Type1 Inactive DFGin 10.028 14.32 BLBminus -141.99, -164.94 53.95, 58.44 -66.89, 145.64 284.8, 75.43 -81.74, 146.41 out-out out 15.147 Saltbr-out 11.827 HRD-in -60.57, -44.96 73.09, -9.93 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -51.59 APE9-dihe-na 147.01, -158.11 APE8-dihe-in -84.1, 102.2 APE8-rot-in 299.84 APE67-dihe-in -53.01, -29.18 -85.5, -22.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.012 APE9-dist-out 9.79 None None None XRAY 3.0 0.196 0.221 D 302 253 16 0 0 16 [[457, 716]] 1.0 5hie TKL_BRAF_HUMAN TKL 5.8e-80 274.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7P3VA 448 719 766.0 5I4:60801 Type1.5_Back Inactive DFGin 6.573 13.864 BLBminus -132.28, -174.45 67.47, 52.83 -58.57, 159.1 307.91, 177.77 -106.73, 178.46 out-out out 11.321 Saltbr-out 9.99 HRD-in -69.94, -53.92 84.86, -4.8 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 46.37 APE8-dihe-out -133.02, 7.4 APE8-rot-in 305.9 APE67-dihe-in -60.12, -27.16 -57.18, -32.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 24.606 V600E None None XRAY 2.37 0.199 0.247 A 275 255 17 0 0 17 [[457, 716]] 1.0 7p3v TKL_BRAF_HUMAN TKL 4.4e-84 288.1 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7P3VB 448 719 766.0 5I4:60801 Type1.5_Back Inactive DFGin 6.599 14.065 BLBminus -139.7, -168.52 56.89, 64.51 -61.24, 134.6 284.56, 99.09 -59.19, 165.99 out-out out 10.205 Saltbr-out 8.783 HRD-in -73.95, -50.21 81.58, -8.37 out-out-out SNCooo out-out ActLoopNT-out 9.015 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -57.16, -48.45 APE9-dihe-na -92.46, 16.67 APE8-dihe-out -115.27, 2.88 APE8-rot-in 311.42 APE67-dihe-in -57.19, -21.5 -69.31, -33.03 APE12-dist-out 16.021 APE11-dist-out 17.041 APE10-dist-out 19.183 APE9-dist-out 27.818 V600E None None XRAY 2.37 0.199 0.247 B 275 272 0 0 0 0 [[457, 716]] 1.0 7p3v TKL_BRAF_HUMAN TKL 4.4e-84 288.1 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4CQEB 448 720 766.0 CQE:1721 Type1.5_Back Inactive DFGin 6.311 14.132 BLBminus -125.28, -175.92 54.18, 61.71 -63.93, 129.8 306.56, 14.82 132.95, 999.0 in-out in 9.88 Saltbr-out 5.188 HRD-in -79.1, -45.33 81.44, -17.5 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -28.49 APE8-dihe-out -103.79, 5.93 APE8-rot-in 295.43 APE67-dihe-in -65.51, -22.37 -48.65, -48.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.803 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.3 0.21 0.255 B 278 248 25 0 0 18 [[457, 716]] 1.0 4cqe TKL_BRAF_HUMAN TKL 4.5e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4XV2A 449 705 766.0 P06:60801 Type1.5_Back Inactive DFGin 6.763 13.948 BLBminus -133.93, -165.69 64.07, 52.33 -63.95, 158.03 294.89, 175.12 -66.38, 999.0 out-out out 10.344 Saltbr-out 7.452 HRD-in -71.95, -45.63 74.38, -8.24 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -20.37 APE8-dihe-in -98.15, 73.68 APE8-rot-out 55.31 APE67-dihe-in -65.42, -22.32 -89.03, -12.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.993 S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R None None XRAY 2.5 0.213 0.244 A 292 232 25 0 0 18 [[457, 716]] 1.0 4xv2 TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4XV2B 448 705 766.0 P06:60801 Type1.5_Back Inactive DFGin 6.819 13.774 BLBminus -141.76, -166.98 57.02, 61.55 -73.62, 172.94 297.53, 174.93 -94.28, 999.0 in-out in 9.976 Saltbr-out 8.713 HRD-in -67.71, -52.17 77.27, -8.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -11.01 APE8-dihe-out -79.14, 4.89 APE8-rot-in 319.95 APE67-dihe-in -63.35, -27.69 -53.48, -40.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.112 S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R None None XRAY 2.5 0.213 0.244 B 292 234 24 0 0 18 [[457, 716]] 1.0 4xv2 TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5CSWB 447 721 766.0 P06:801 Type1.5_Back Inactive DFGin 6.566 14.173 BLBminus -145.39, -140.94 43.16, 61.8 -68.34, 137.1 284.56, 18.12 -76.08, 152.66 out-out out 10.713 Saltbr-out 8.739 HRD-in -69.52, -52.78 80.79, -11.78 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -28.45 APE8-rot-in 308.43 APE67-dihe-in -56.08, -31.02 -67.74, -22.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 2.66 0.22 0.282 B 282 252 23 0 0 18 [[457, 716]] 1.0 5csw TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6V2UB 449 720 766.0 P06:801 Type1.5_Back Inactive DFGin 6.762 13.777 BLBminus -153.94, -155.26 51.92, 62.16 -71.1, 141.57 289.52, 177.82 -77.09, 149.3 out-out out 10.592 Saltbr-out 8.699 HRD-in -70.71, -52.85 79.91, -12.49 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -21.81 APE8-rot-in 289.14 APE67-dihe-in -65.05, -25.48 -78.98, -16.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.78 0.282 0.309 B 283 250 22 0 0 18 [[457, 716]] 1.0 6v2u TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
9AXYA 448 722 766.0 ANP:801 ATPlike Inactive DFGin 5.917 13.541 BLBplus -133.51, 174.13 59.27, 33.71 -86.77, 154.56 49.71, 87.92 69.37, -142.48 out-out out 14.096 Saltbr-out 13.007 HRD-in -70.93, -41.64 75.57, -39.02 out-out-out SNCooo out-out ActLoopNT-out 9.069 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -141.06, 145.96 APE9-dihe-na 71.75, -130.61 APE8-dihe-in -87.56, 149.58 APE8-rot-out 200.58 APE67-dihe-in -69.57, -29.74 -96.77, -9.15 APE12-dist-out 14.194 APE11-dist-out 15.515 APE10-dist-out 11.663 APE9-dist-out 9.677 None None None XRAY 3.6 0.19 0.237 A 280 275 0 0 0 0 [[457, 716]] 1.0 9axy TKL_BRAF_HUMAN TKL 7.8e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6PP9A 447 722 766.0 ANP:801 ATPlike Inactive DFGin 5.342 13.498 BLBplus -130.79, 177.54 57.37, 43.96 -96.57, 156.54 49.86, 89.0 63.47, -135.71 out-out out 14.313 Saltbr-out 12.69 HRD-in -66.97, -47.8 65.51, 3.6 out-out-out SNCooo out-out ActLoopNT-out 9.256 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -142.44, 146.23 APE9-dihe-na 73.26, -154.57 APE8-dihe-in -71.36, 154.2 APE8-rot-out 182.15 APE67-dihe-in -61.64, -19.53 -112.25, -5.75 APE12-dist-out 15.201 APE11-dist-out 15.9 APE10-dist-out 12.693 APE9-dist-out 10.139 None None None XRAY 2.59 0.222 0.245 A 283 276 0 0 0 0 [[457, 716]] 1.0 6pp9 TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6V2WA 447 721 766.0 ANP:801 ATPlike Inactive DFGin 5.532 13.704 BLBplus -135.72, 175.83 57.63, 35.46 -91.96, 158.82 53.8, 96.09 64.15, -137.39 out-out out 14.475 Saltbr-out 12.433 HRD-in -69.37, -44.53 66.04, 8.13 out-out-out SNCooo out-out ActLoopNT-out 8.99 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -146.39, 170.31 APE9-dihe-na 111.41, -172.95 APE8-dihe-in -92.84, 135.37 APE8-rot-out 52.69 APE67-dihe-in -65.1, -26.74 -72.43, -22.76 APE12-dist-out 14.729 APE11-dist-out 14.898 APE10-dist-out 12.159 APE9-dist-out 6.256 None None None XRAY 3.12 0.189 0.237 A 283 275 0 0 0 0 [[457, 716]] 1.0 6v2w TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7M0TA 448 721 766.0 ANP:801 ATPlike Inactive DFGin 5.483 13.645 BLBplus -101.53, -171.54 49.12, 40.35 -93.39, 158.36 49.68, 91.24 67.74, -141.33 out-out out 14.633 Saltbr-out 13.418 HRD-in -63.36, -50.98 81.19, -14.99 out-out-out SNCooo out-out ActLoopNT-out 9.096 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iooo APE10-dihe-na -146.63, 169.35 APE9-dihe-na 113.78, -178.56 APE8-dihe-in -87.12, 141.18 APE8-rot-out 208.64 APE67-dihe-out -59.38, 160.81 -70.93, -34.96 APE12-dist-in 13.663 APE11-dist-out 15.277 APE10-dist-out 12.449 APE9-dist-out 6.689 None None None XRAY 3.19 0.199 0.254 A 283 274 0 0 0 0 [[457, 716]] 1.0 7m0t TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7M0UA 449 722 766.0 ANP:801 ATPlike Inactive DFGin 5.826 13.545 BLBplus -114.76, -174.76 53.19, 33.71 -86.73, 158.23 49.19, 93.22 61.58, -136.88 out-out out 14.508 Saltbr-out 13.628 HRD-in -66.62, -51.93 79.28, -5.3 out-out-out SNCooo out-out ActLoopNT-out 8.968 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -137.94, 171.17 APE9-dihe-na 125.59, 173.92 APE8-dihe-in -78.53, 136.46 APE8-rot-out 49.62 APE67-dihe-in -63.36, -26.84 -75.55, -22.51 APE12-dist-out 14.59 APE11-dist-out 14.476 APE10-dist-out 12.102 APE9-dist-out 6.331 None None None XRAY 3.09 0.193 0.23 A 283 274 0 0 0 0 [[457, 716]] 1.0 7m0u TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7M0VA 449 722 766.0 ANP:801 ATPlike Inactive DFGin 5.741 13.29 BLBplus -118.84, -178.01 61.17, 44.22 -99.98, 160.93 40.29, 99.45 62.33, -140.62 out-out out 14.111 Saltbr-out 13.141 HRD-in -76.68, -47.66 79.51, -34.29 out-out-out SNCooo out-out ActLoopNT-out 9.324 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -140.71, 145.59 APE9-dihe-na 81.77, -131.39 APE8-dihe-in -106.29, 148.31 APE8-rot-out 201.4 APE67-dihe-in -54.29, -30.39 -107.29, -13.89 APE12-dist-in 13.909 APE11-dist-out 15.777 APE10-dist-out 12.613 APE9-dist-out 10.163 None None None XRAY 3.16 0.188 0.234 A 283 274 0 0 0 0 [[457, 716]] 1.0 7m0v TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7M0WA 448 721 766.0 ANP:801 ATPlike Inactive DFGin 5.7 13.563 BLBplus -128.57, -174.24 58.52, 36.11 -93.32, 163.98 47.26, 91.72 57.0, -141.37 out-out out 14.273 Saltbr-out 13.044 HRD-in -64.47, -50.11 78.2, -6.17 out-out-out SNCooo out-out ActLoopNT-out 8.98 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -140.16, 158.71 APE9-dihe-na 121.26, -178.69 APE8-dihe-in -87.94, 138.93 APE8-rot-out 43.99 APE67-dihe-in -65.6, -30.89 -79.08, -13.62 APE12-dist-out 14.335 APE11-dist-out 15.342 APE10-dist-out 12.134 APE9-dist-out 6.651 None None None XRAY 3.09 0.197 0.233 A 283 274 0 0 0 0 [[457, 716]] 1.0 7m0w TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7M0XA 447 722 766.0 ANP:801 ATPlike Inactive DFGin 5.445 13.495 BLBplus -123.82, 174.92 60.79, 42.33 -96.45, 161.16 49.04, 90.67 58.85, -140.33 out-out out 14.265 Saltbr-out 13.063 HRD-in -65.53, -50.34 78.03, -10.0 out-out-out SNCooo out-out ActLoopNT-out 9.245 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -141.24, 149.26 APE9-dihe-na 65.43, -162.66 APE8-dihe-in -61.59, 142.77 APE8-rot-out 179.57 APE67-dihe-in -62.52, -26.23 -97.92, -3.07 APE12-dist-out 15.152 APE11-dist-out 15.966 APE10-dist-out 12.626 APE9-dist-out 10.084 None None None XRAY 2.47 0.18 0.215 A 283 276 0 0 0 0 [[457, 716]] 1.0 7m0x TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7M0YA 447 721 766.0 ANP:801 ATPlike Inactive DFGin 5.925 13.72 BLBplus -130.12, 178.08 53.67, 39.87 -94.09, 143.26 51.07, 86.66 77.46, -140.33 out-out out 14.454 Saltbr-out 12.42 HRD-in -66.6, -53.86 81.89, -14.1 out-out-out SNCooo out-out ActLoopNT-out 8.968 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -138.96, 162.77 APE9-dihe-na 110.62, -175.34 APE8-dihe-in -77.87, 138.5 APE8-rot-out 52.44 APE67-dihe-in -64.93, -32.89 -83.52, -17.07 APE12-dist-out 14.226 APE11-dist-out 15.27 APE10-dist-out 12.007 APE9-dist-out 6.781 None None None XRAY 3.45 0.196 0.218 A 283 275 0 0 0 0 [[457, 716]] 1.0 7m0y TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7M0ZA 449 721 766.0 ANP:801 ATPlike Inactive DFGin 5.591 13.558 BLBplus -131.23, -177.35 57.24, 31.09 -88.02, 155.4 49.99, 89.35 66.37, -137.56 out-out out 14.378 Saltbr-out 12.797 HRD-in -63.1, -49.11 70.7, -2.29 out-out-out SNCooo out-out ActLoopNT-out 8.934 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -140.88, 158.66 APE9-dihe-na 126.45, -167.01 APE8-dihe-in -93.79, 132.25 APE8-rot-out 208.38 APE67-dihe-in -66.35, -24.31 -75.16, -20.55 APE12-dist-in 12.987 APE11-dist-out 14.918 APE10-dist-out 11.822 APE9-dist-out 6.385 None None None XRAY 3.12 0.193 0.225 A 283 273 0 0 0 0 [[457, 716]] 1.0 7m0z TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
9ECUA 447 722 766.0 ANP:801 ATPlike Inactive DFGin 5.395 13.556 BLBplus -125.65, 169.46 60.46, 40.01 -87.45, 154.95 47.27, 91.45 64.75, -132.56 out-out out 13.975 Saltbr-out 13.736 HRD-in -64.53, -58.29 87.19, -19.63 out-out-out SNCooo out-out ActLoopNT-out 9.233 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -128.75, 123.72 APE9-dihe-na 163.56, -169.21 APE8-dihe-in -104.16, 118.8 APE8-rot-in 298.64 APE67-dihe-in -60.82, -35.98 -59.26, -34.28 APE12-dist-out 14.691 APE11-dist-out 15.132 APE10-dist-out 11.51 APE9-dist-out 6.31 None None None XRAY 3.46 0.202 0.237 A 284 276 0 0 0 0 [[457, 716]] 1.0 9ecu TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6U2GB 451 722 766.0 ACP:901 ATPlike Inactive DFGin 6.15 13.909 BLBplus -127.14, -173.09 46.65, 53.2 -113.93, 152.92 52.73, 94.7 72.25, -152.99 out-out out 14.606 Saltbr-out 12.705 HRD-in -59.19, -53.53 76.48, -9.73 out-out-out SNCooo out-out ActLoopNT-out 9.495 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -146.07, 161.59 APE9-dihe-na 90.18, -141.72 APE8-dihe-in -101.38, 139.04 APE8-rot-out 180.97 APE67-dihe-in -60.58, -31.67 -70.85, -22.56 APE12-dist-out 15.336 APE11-dist-out 15.709 APE10-dist-out 13.592 APE9-dist-out 9.892 None None None XRAY 2.886 0.231 0.276 B 307 264 8 0 0 8 [[457, 716]] 1.0 6u2g TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6NYBA 233 738 766.0 AGS:60801 ATPlike Inactive DFGin 5.498 13.825 BLBplus -130.99, 171.98 57.42, 47.58 -103.38, 154.64 56.0, 92.93 63.13, -128.72 out-out out 13.824 Saltbr-out 12.604 HRD-in -73.31, -44.18 67.31, 1.32 out-out-out SNCooo out-out ActLoopNT-out 9.065 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -162.22, 166.73 APE9-dihe-na 98.18, -110.24 APE8-dihe-in -136.25, 146.51 APE8-rot-out 61.57 APE67-dihe-in -62.67, -27.04 -119.01, -4.59 APE12-dist-out 14.66 APE11-dist-out 15.641 APE10-dist-out 13.882 APE9-dist-out 8.763 None SEP365,SEP729 SEP365,SEP729 EM 4.1 999.0 999.0 A 805 350 0 0 0 0 [[457, 716]] 1.0 6nyb TKL_BRAF_HUMAN TKL 1.4e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
8DGSA 155 738 766.0 AGS:60801 ATPlike Inactive DFGin 6.606 13.238 BLBplus -138.09, -166.17 58.48, 64.88 -134.87, 173.46 48.16, 90.78 58.1, -132.32 out-out out 14.522 Saltbr-out 12.258 HRD-in -71.36, -47.09 71.02, -12.92 out-out-out SNCooo out-out ActLoopNT-out 9.554 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -160.2, 161.72 APE9-dihe-na 103.44, -137.95 APE8-dihe-in -102.25, 169.61 APE8-rot-in 312.72 APE67-dihe-in -64.56, -41.44 -121.48, -15.09 APE12-dist-out 14.082 APE11-dist-out 15.843 APE10-dist-out 12.46 APE9-dist-out 8.209 None SEP365,SEP729 SEP365,SEP729 EM 4.3 999.0 999.0 A 805 427 0 0 0 0 [[457, 716]] 1.0 8dgs TKL_BRAF_HUMAN TKL 1.4e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
8DGTA 151 738 766.0 AGS:60801 ATPlike Inactive DFGin 5.641 13.675 BLBplus -132.23, 178.7 56.78, 46.46 -100.79, 153.62 51.93, 96.21 64.7, -132.47 out-out out 13.923 Saltbr-out 12.693 HRD-in -71.52, -43.55 65.96, -9.54 out-out-out SNCooo out-out ActLoopNT-out 8.998 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -155.42, 128.83 APE9-dihe-na 147.85, 157.58 APE8-dihe-in -55.44, 116.98 APE8-rot-out 39.4 APE67-dihe-in -65.02, -24.91 -67.41, -12.47 APE12-dist-out 14.368 APE11-dist-out 14.543 APE10-dist-out 11.934 APE9-dist-out 6.457 None SEP365,SEP729 SEP365,SEP729 EM 3.9 999.0 999.0 A 805 431 0 0 0 0 [[457, 716]] 1.0 8dgt TKL_BRAF_HUMAN TKL 1.4e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7MFDA 156 738 766.0 No_ligand No_ligand Inactive DFGin 6.133 14.028 BLBplus -147.17, -167.77 58.95, 63.63 -141.3, 173.3 63.34, 90.1 84.7, -138.28 out-out out 13.444 Saltbr-out 14.964 HRD-in -65.44, -45.07 53.09, 12.91 out-out-out SNCooo out-out ActLoopNT-out 10.126 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -115.53, 118.71 APE9-dihe-na 124.14, -152.32 APE8-dihe-out -80.3, -174.47 APE8-rot-out 175.42 APE67-dihe-in -88.54, -38.49 -131.9, 1.65 APE12-dist-in 12.524 APE11-dist-out 15.293 APE10-dist-out 11.941 APE9-dist-out 9.006 None SEP365,SEP729 SEP365,SEP729 EM 3.66 999.0 999.0 A 766 410 0 0 0 0 [[457, 716]] 1.0 7mfd TKL_BRAF_HUMAN TKL 1.3e-80 277.1 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7MFEA 156 738 766.0 No_ligand No_ligand Inactive DFGin 5.592 14.077 BLBplus -177.8, -165.52 58.54, 65.19 -141.16, 177.04 83.19, 84.53 83.39, -159.89 out-out out 13.98 Saltbr-out 13.724 HRD-in -67.64, -50.06 72.14, -8.98 out-out-out SNCooo out-out ActLoopNT-out 9.848 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -158.83, 165.63 APE9-dihe-na 60.73, -126.1 APE8-dihe-in -116.98, 164.64 APE8-rot-out 62.4 APE67-dihe-in -73.69, -58.3 -108.21, 16.9 APE12-dist-in 13.855 APE11-dist-out 15.971 APE10-dist-out 12.319 APE9-dist-out 8.857 None SEP365,SEP729 SEP365,SEP729 EM 4.07 999.0 999.0 A 766 409 0 0 0 0 [[457, 716]] 1.0 7mfe TKL_BRAF_HUMAN TKL 1.3e-80 277.1 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
9O2ZA 156 738 766.0 No_ligand No_ligand Inactive DFGin 5.227 14.852 BLBplus -158.75, -165.27 58.03, 65.17 -135.36, 168.35 93.37, 94.37 65.45, -126.84 out-out out 14.181 Saltbr-out 12.733 HRD-in -63.04, -43.06 56.11, 7.15 out-out-out SNCooo out-out ActLoopNT-out 10.052 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -122.26, 135.07 APE9-dihe-na 116.39, -152.99 APE8-dihe-in -82.69, 172.63 APE8-rot-out 176.75 APE67-dihe-in -65.4, -27.16 -118.54, -27.57 APE12-dist-in 12.399 APE11-dist-out 15.332 APE10-dist-out 12.287 APE9-dist-out 9.286 None SEP365,SEP729 SEP365,SEP729 EM 3.83 999.0 999.0 A 766 412 0 0 0 0 [[457, 716]] 1.0 9o2z TKL_BRAF_HUMAN TKL 1.3e-80 277.1 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
8VYOA 235 738 766.0 No_ligand No_ligand Inactive DFGin 6.329 11.959 BLBplus -106.72, -170.53 56.46, 17.56 -67.21, 152.55 41.04, 73.92 52.43, -143.18 out-out out 14.4 Saltbr-out 10.253 HRD-in -71.72, -18.44 66.71, -45.69 out-out-out SNCooo out-out ActLoopNT-out 8.463 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -118.68 APE8-dihe-in -140.61, 156.59 APE8-rot-out 63.25 APE67-dihe-out -119.23, -9.19 -147.56, 106.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.692 None SEP365,SEP729 SEP365,SEP729 EM 3.74 999.0 999.0 A 767 309 19 0 0 12 [[457, 716]] 1.0 8vyo TKL_BRAF_HUMAN TKL 1.3e-80 277.1 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3C4CA 448 721 766.0 324:60002 Type1.5_Back Inactive DFGin 5.638 13.547 BLBplus -139.33, -169.83 64.62, 39.85 -103.64, 171.83 60.3, 95.42 83.99, 999.0 out-out out 11.62 Saltbr-out 8.693 HRD-in -73.87, -57.97 102.26, -19.82 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, -163.04 APE9-dihe-na -121.17, -138.04 APE8-dihe-in -92.13, 91.4 APE8-rot-out 47.35 APE67-dihe-in -63.77, -25.31 -68.49, -17.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.55 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 2.57 0.261 0.303 A 280 257 17 0 0 17 [[457, 716]] 1.0 3c4c TKL_BRAF_HUMAN TKL 4.5e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4XV3B 448 705 766.0 No_ligand No_ligand Inactive DFGin 6.285 15.063 None -134.59, -161.64 56.33, 52.08 -63.4, 999.0 279.75, 63.83 999.0, 999.0 in-in in 8.928 Saltbr-in 3.324 HRD-in -65.71, -41.29 62.65, 10.76 in-in-out SNCiio in-out ActLoopNT-in 2.983 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -32.28 APE8-dihe-out -76.54, 7.27 APE8-rot-in 304.4 APE67-dihe-in -61.73, -25.86 -63.95, -33.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.701 S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R None None XRAY 2.8 0.26 0.296 B 292 225 33 0 0 16 [[457, 716]] 1.0 4xv3 TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4FK3B 448 721 766.0 No_ligand No_ligand Inactive DFGin 5.772 14.711 None -140.8, -152.47 49.25, 52.94 -56.33, -72.64 272.7, 56.86 47.33, -79.68 in-out in 9.045 Saltbr-out 5.373 HRD-in -75.07, -44.36 65.22, -1.5 out-in-out SNCoio in-out ActLoopNT-in 3.194 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 141.11 APE9-dihe-na 86.3, -24.42 APE8-dihe-out -101.18, 22.22 APE8-rot-out 89.79 APE67-dihe-in -68.94, -26.21 -73.51, -33.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.132 APE9-dist-out 11.411 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.65 0.262 0.315 B 292 257 17 0 0 13 [[457, 716]] 1.0 4fk3 TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3OG7B 449 720 766.0 No_ligand No_ligand Inactive DFGin 5.961 14.384 None -166.94, -137.57 40.92, 51.52 -52.94, -84.66 283.54, 98.08 68.73, -46.65 in-in in 8.951 Saltbr-in 2.588 HRD-in -73.27, -47.93 73.19, 0.79 in-in-out SNCiio in-out ActLoopNT-in 2.969 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -31.76 APE8-dihe-out -68.94, -9.04 APE8-rot-in 313.5 APE67-dihe-in -62.19, -30.71 -52.08, -39.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.037 K522A,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 2.45 0.214 0.258 B 289 254 18 0 0 14 [[457, 716]] 1.0 3og7 TKL_BRAF_HUMAN TKL 1.2e-83 286.6 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6UUOA 450 722 766.0 QH1:801 Type1 Inactive DFGin 5.483 13.575 None -154.98, -157.82 59.8, 46.61 -126.81, 999.0 56.6, 86.97 999.0, 999.0 out-none out 10.441 Saltbr-none 999.0 HRD-out -76.54, 102.1 -78.95, -33.04 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -71.64, -31.02 APE9-dihe-na -70.11, -42.33 APE8-dihe-out -89.38, 32.83 APE8-rot-in 313.94 APE67-dihe-in -71.42, -39.61 -73.97, -40.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 28.326 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.288 0.265 0.288 A 284 254 19 0 0 14 [[457, 716]] 1.0 6uuo TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4H58A 448 722 766.0 10Z:60801 Type1 Inactive DFGin 5.96 13.722 None -110.59, -118.32 -39.31, 108.26 -95.89, 11.56 277.46, 88.25 -35.77, -74.73 in-in in 8.302 Saltbr-in 2.764 HRD-in -69.13, -43.65 65.49, 6.98 in-in-out SNCiio in-out ActLoopNT-in 2.835 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnio APE10-dihe-na 999.0, 79.67 APE9-dihe-na -70.74, 22.44 APE8-dihe-in -101.01, 94.21 APE8-rot-in 260.42 APE67-dihe-in -50.49, -22.55 -89.83, -41.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.565 APE9-dist-out 10.307 None None None XRAY 3.1 0.224 0.272 A 275 263 12 0 0 12 [[457, 716]] 1.0 4h58 TKL_BRAF_HUMAN TKL 7.3e-82 280.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3PRFB 448 723 766.0 FP3:727 Type1 Inactive DFGin 6.428 13.643 None -169.57, 116.91 168.47, 123.69 -125.85, 47.13 283.69, 79.02 -70.43, 82.93 in-in in 8.154 Saltbr-in 2.997 HRD-in -67.72, -35.03 62.32, -6.1 in-out-out SNCioo out-out ActLoopNT-out 5.602 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -169.48 APE8-dihe-in -103.48, 122.52 APE8-rot-in 275.2 APE67-dihe-in -59.13, -20.14 -98.86, -20.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.526 None None None XRAY 2.9 0.271 0.31 B 307 262 14 0 0 14 [[457, 716]] 1.0 3prf TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5CSWA 449 721 766.0 P06:801 Type1.5_Back Inactive DFGin 6.563 13.725 None -154.89, -152.27 52.45, 58.54 -68.5, 999.0 303.98, 168.7 999.0, 999.0 out-out out 10.269 Saltbr-out 7.429 HRD-in -64.98, -59.02 86.25, -16.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 30.46 APE8-dihe-out -158.22, 46.88 APE8-rot-in 285.64 APE67-dihe-in -66.32, -23.33 -79.02, -14.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.364 R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 2.66 0.22 0.282 A 282 254 19 0 0 19 [[457, 716]] 1.0 5csw TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5ITAB 448 721 766.0 6DC:801 Type1.5_Back Inactive DFGin 5.363 13.803 None -122.71, -173.14 61.94, 63.43 -148.55, 999.0 64.56, 89.23 999.0, 999.0 out-in out 10.351 Saltbr-in 3.533 HRD-in -69.84, -55.2 76.82, -4.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, -11.31 APE9-dihe-na -82.19, 19.66 APE8-dihe-out -126.85, 23.68 APE8-rot-in 305.8 APE67-dihe-in -61.03, -25.66 -65.06, -28.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.333 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 1.95 0.197 0.244 B 297 252 22 0 0 18 [[457, 716]] 1.0 5ita TKL_BRAF_HUMAN TKL 5.7e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6V2UA 449 721 766.0 P06:801 Type1.5_Back Inactive DFGin 6.785 13.871 None -154.67, -156.07 52.1, 63.13 -70.26, 999.0 290.51, 178.01 999.0, 999.0 out-none out 10.27 Saltbr-none 999.0 HRD-in -70.43, -53.73 79.13, -11.56 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, -132.33 APE9-dihe-na -124.36, 116.11 APE8-dihe-in -169.83, 67.75 APE8-rot-in 288.88 APE67-dihe-in -62.03, -24.27 -79.94, -15.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.486 None None None XRAY 3.78 0.282 0.309 A 283 255 18 0 0 18 [[457, 716]] 1.0 6v2u TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4MBJA 448 723 766.0 DFS:801 Type1.5_Back Inactive DFGin 5.04 14.172 None -105.17, -97.55 -92.89, 45.25 -92.17, -5.13 71.79, 75.67 -66.15, 168.52 out-out out 11.905 Saltbr-out 10.125 HRD-in -75.95, -40.1 71.4, -7.47 out-out-out SNCooo out-out ActLoopNT-out 8.69 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na 173.82, -65.98 APE9-dihe-na -61.43, -19.22 APE8-dihe-in -120.24, 91.44 APE8-rot-out 31.9 APE67-dihe-in -51.31, -26.45 -118.43, -32.49 APE12-dist-none 999.0 APE11-dist-out 14.519 APE10-dist-out 17.705 APE9-dist-out 11.07 None None None XRAY 3.6 0.276 0.328 A 304 269 7 0 0 7 [[457, 716]] 1.0 4mbj TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4MBJB 448 723 766.0 DFS:801 Type1.5_Back Inactive DFGin 5.023 14.149 None -106.4, -95.1 -95.18, 47.42 -92.84, -5.68 72.56, 75.57 -66.19, 170.04 out-out out 11.925 Saltbr-out 10.201 HRD-in -72.66, -45.72 76.66, -7.37 out-out-out SNCooo out-out ActLoopNT-out 8.704 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na 171.46, -66.25 APE9-dihe-na -61.77, -19.59 APE8-dihe-in -119.83, 90.82 APE8-rot-out 33.61 APE67-dihe-in -51.95, -27.84 -118.81, -32.64 APE12-dist-in 11.252 APE11-dist-out 14.492 APE10-dist-out 17.693 APE9-dist-out 11.058 None None None XRAY 3.6 0.276 0.328 B 304 276 0 0 0 0 [[457, 716]] 1.0 4mbj TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4H58C 449 722 766.0 No_ligand No_ligand Inactive DFGout 12.314 12.229 BBAminus -160.6, -162.0 -123.7, 93.43 -89.2, -0.33 292.68, 81.74 36.99, -133.77 in-in in 7.705 Saltbr-in 2.647 HRD-in -62.88, -49.99 78.35, 6.93 in-out-out SNCioo out-out ActLoopNT-out 18.505 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -120.11, -16.47 APE9-dihe-na -80.65, -129.6 APE8-dihe-in -116.99, 109.87 APE8-rot-in 290.33 APE67-dihe-in -66.58, -13.25 -83.92, -32.56 APE12-dist-out 20.827 APE11-dist-out 17.582 APE10-dist-out 13.409 APE9-dist-out 9.258 None None None XRAY 3.1 0.224 0.272 C 275 272 2 0 0 0 [[457, 716]] 1.0 4h58 TKL_BRAF_HUMAN TKL 7.3e-82 280.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4G9RB 448 721 766.0 B1E:801 Type1 Inactive DFGout 12.547 11.72 BBAminus -147.94, -171.25 -121.56, 97.8 -91.5, -5.17 309.53, 111.01 -58.05, 149.39 in-in in 8.782 Saltbr-in 2.627 HRD-in -65.66, -45.28 76.96, -21.52 in-out-out SNCioo out-out ActLoopNT-out 13.877 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -133.81 APE8-dihe-in -92.38, 126.95 APE8-rot-in 272.42 APE67-dihe-in -63.84, -25.88 -100.21, -30.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.21 V600E None None XRAY 3.2 0.229 0.277 B 307 261 13 0 0 13 [[457, 716]] 1.0 4g9r TKL_BRAF_HUMAN TKL 1.1e-81 280.2 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5CSXA 448 720 766.0 54J:801 Type1.5_Back Inactive DFGout 13.281 11.102 BBAminus -150.59, -157.43 -140.52, 94.87 -94.05, 9.61 293.76, 75.18 -76.48, 136.85 out-out out 10.528 Saltbr-out 5.656 HRD-in -70.41, -44.57 77.65, -9.55 out-out-out SNCooo out-out ActLoopNT-out 15.571 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -69.23 APE9-dihe-na -103.11, 22.42 APE8-dihe-out -123.47, 4.1 APE8-rot-in 303.94 APE67-dihe-in -63.23, -27.45 -60.87, -31.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.462 APE9-dist-out 10.951 R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 2.51 0.223 0.282 A 282 261 12 0 0 10 [[457, 716]] 1.0 5csx TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
8C7YA 448 721 766.0 TXV:60819 Type2 Inactive DFGout 12.408 11.726 BBAminus -137.73, -175.36 -123.6, 90.82 -84.7, -1.49 298.01, 93.91 -135.43, 40.89 in-in in 8.387 Saltbr-in 2.85 HRD-in -66.11, -47.81 81.15, -13.03 in-out-out SNCioo out-out ActLoopNT-out 14.657 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -57.81, -31.54 APE9-dihe-na -75.2, -3.67 APE8-dihe-out -121.03, -1.94 APE8-rot-in 304.31 APE67-dihe-in -66.09, -22.26 -55.41, -37.84 APE12-dist-in 10.58 APE11-dist-in 10.609 APE10-dist-out 14.146 APE9-dist-out 10.866 V600E None None XRAY 1.65 0.153 0.175 A 282 274 0 0 0 0 [[457, 716]] 1.0 8c7y TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
8C7YB 449 721 766.0 TXV:60803 Type2 Inactive DFGout 12.204 11.719 BBAminus -146.3, -168.52 -130.63, 88.27 -86.35, -12.6 298.57, 95.44 49.99, -135.3 in-in in 8.379 Saltbr-in 2.775 HRD-in -71.56, -48.93 77.75, -10.34 in-out-out SNCioo out-out ActLoopNT-out 18.062 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 5.82 APE8-dihe-out -125.92, 1.76 APE8-rot-in 306.06 APE67-dihe-in -66.57, -23.27 -61.15, -28.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.759 V600E None None XRAY 1.65 0.153 0.175 B 282 258 15 0 0 15 [[457, 716]] 1.0 8c7y TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6V34A 449 721 766.0 QOP:60801 Type2 Inactive DFGout 12.434 11.575 BBAminus -154.0, -169.02 -128.32, 93.65 -90.71, 10.51 309.15, 147.81 -68.37, 132.98 in-in in 9.086 Saltbr-in 2.538 HRD-in -69.77, -32.09 68.47, -18.7 in-out-out SNCioo out-out ActLoopNT-out 14.574 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 76.8 APE9-dihe-na -77.41, 65.97 APE8-dihe-in -153.14, 51.16 APE8-rot-in 295.33 APE67-dihe-in -64.54, -20.97 -83.49, -26.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.524 APE9-dist-out 11.638 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 3.15 0.257 0.286 A 283 254 19 0 0 14 [[457, 716]] 1.0 6v34 TKL_BRAF_HUMAN TKL 4.9e-84 287.9 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6V34B 449 721 766.0 QOP:60801 Type2 Inactive DFGout 12.56 11.92 BBAminus -154.71, -167.6 -127.21, 92.8 -91.69, -108.51 309.26, 147.08 122.27, 999.0 in-in in 9.301 Saltbr-in 2.891 HRD-in -70.04, -32.52 68.23, -18.05 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.85, -18.83 999.0, -26.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 3.15 0.257 0.286 B 283 247 26 0 0 20 [[457, 716]] 1.0 6v34 TKL_BRAF_HUMAN TKL 4.9e-84 287.9 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4R5YA 449 720 766.0 3K3:801 Type2 Inactive DFGout 12.424 11.403 BBAminus -178.69, -170.96 -106.97, 94.73 -95.79, 9.88 289.99, 76.28 -115.28, 999.0 in-out in 8.866 Saltbr-out 5.529 HRD-in -60.99, -46.63 78.01, -10.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -4.67 APE8-rot-out 203.05 APE67-dihe-in -69.84, -20.28 -83.09, -13.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.5 0.229 0.306 A 292 253 19 0 0 19 [[457, 716]] 1.0 4r5y TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4R5YB 449 720 766.0 3K3:801 Type2 Inactive DFGout 12.727 11.371 BBAminus -171.56, -169.77 -112.44, 105.89 -99.56, 4.22 290.31, 63.5 -85.76, 129.56 in-out in 8.573 Saltbr-out 5.139 HRD-out -74.44, 104.88 -75.35, 1.11 out-out-out SNCooo out-out ActLoopNT-out 16.506 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -62.43 APE9-dihe-na -110.62, 18.0 APE8-dihe-out -132.72, 21.46 APE8-rot-in 308.12 APE67-dihe-in -68.31, -34.38 -66.71, -16.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.501 APE9-dist-out 10.835 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.5 0.229 0.306 B 292 254 18 0 0 14 [[457, 716]] 1.0 4r5y TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6XFPA 449 720 766.0 V1Y:801 Type2 Inactive DFGout 12.785 11.794 BBAminus -152.68, -168.04 -122.37, 95.79 -81.47, -2.45 289.34, 78.53 -103.07, -17.89 in-in in 8.82 Saltbr-in 2.68 HRD-in -72.84, -49.41 80.71, -18.06 in-out-out SNCioo out-out ActLoopNT-out 15.912 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -63.42, 112.38 APE9-dihe-na 63.49, 13.54 APE8-dihe-out -120.51, -9.67 APE8-rot-in 293.98 APE67-dihe-in -68.28, -18.63 -59.36, -37.51 APE12-dist-in 10.898 APE11-dist-out 14.068 APE10-dist-out 10.739 APE9-dist-out 10.978 None None None XRAY 2.0 0.207 0.257 A 288 272 0 0 0 0 [[457, 716]] 1.0 6xfp TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6XLOA 449 720 766.0 V5J:801 Type2 Inactive DFGout 12.584 12.478 BBAminus -143.26, -154.83 -139.35, 81.57 -80.55, 3.31 328.42, 130.67 -78.49, 138.96 in-in in 8.236 Saltbr-in 2.674 HRD-in -62.92, -51.69 76.71, -8.67 in-out-out SNCioo out-out ActLoopNT-out 14.203 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -50.07, -31.4 APE9-dihe-na -91.29, 26.43 APE8-dihe-out -148.42, -12.6 APE8-rot-in 284.88 APE67-dihe-in -62.29, -18.91 -54.15, -42.06 APE12-dist-in 10.361 APE11-dist-in 11.867 APE10-dist-out 13.072 APE9-dist-out 10.899 None None None XRAY 2.493 0.237 0.267 A 288 258 14 0 0 5 [[457, 716]] 1.0 6xlo TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6XLOB 450 720 766.0 V5J:801 Type2 Inactive DFGout 12.584 12.441 BBAminus -143.08, -155.74 -139.03, 82.3 -80.56, 3.3 327.55, 70.15 -79.44, 140.59 in-in in 8.225 Saltbr-in 2.637 HRD-in -63.28, -51.61 76.36, -9.34 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -12.77 APE8-rot-in 284.58 APE67-dihe-in -62.16, -19.3 -54.01, -41.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.493 0.237 0.267 B 288 250 21 0 0 18 [[457, 716]] 1.0 6xlo TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7K0VA 449 722 766.0 VQP:801 Type2 Inactive DFGout 12.195 11.918 BBAminus -162.68, -156.07 -117.9, 96.89 -109.54, 16.15 299.04, 103.45 -77.91, 116.59 in-in in 8.676 Saltbr-in 3.148 HRD-in -72.28, -41.59 81.4, -9.83 in-out-out SNCioo out-out ActLoopNT-out 23.093 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -92.4, 141.9 APE9-dihe-na -84.31, -172.93 APE8-dihe-in -81.24, 56.12 APE8-rot-in 309.48 APE67-dihe-in -74.89, -22.92 -59.56, -24.75 APE12-dist-in 9.752 APE11-dist-out 15.297 APE10-dist-out 14.399 APE9-dist-out 8.984 None None None XRAY 1.93 0.187 0.23 A 288 262 12 0 0 9 [[457, 716]] 1.0 7k0v TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7K0VB 449 722 766.0 VQP:801 Type2 Inactive DFGout 12.34 11.701 BBAminus -167.19, -159.19 -104.12, 109.97 -117.14, 1.82 293.72, 96.78 -102.83, -58.49 in-in in 8.352 Saltbr-in 2.756 HRD-in -71.48, -47.17 73.94, -6.06 in-out-out SNCioo out-out ActLoopNT-out 14.087 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -97.2, 2.25 APE9-dihe-na 176.29, 177.5 APE8-dihe-out 64.18, 15.92 APE8-rot-in 287.72 APE67-dihe-in -68.76, -19.22 -66.09, -26.1 APE12-dist-out 14.721 APE11-dist-out 16.447 APE10-dist-out 12.441 APE9-dist-out 10.103 None None None XRAY 1.93 0.187 0.23 B 288 264 10 0 0 7 [[457, 716]] 1.0 7k0v TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7K0VC 448 722 766.0 VQP:801 Type2 Inactive DFGout 12.415 11.312 BBAminus -149.63, -160.06 -140.65, 98.9 -96.4, 9.54 307.52, 103.4 -76.49, 147.45 in-in in 8.558 Saltbr-in 2.727 HRD-in -65.37, -52.41 83.32, -6.12 in-out-out SNCioo out-out ActLoopNT-out 18.181 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -119.69 APE8-dihe-out -98.34, 2.05 APE8-rot-in 283.36 APE67-dihe-in -63.48, -24.0 -64.49, -30.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.091 None None None XRAY 1.93 0.187 0.23 C 288 267 8 0 0 8 [[457, 716]] 1.0 7k0v TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7K0VD 449 722 766.0 VQP:801 Type2 Inactive DFGout 12.377 11.418 BBAminus -149.15, -161.3 -137.52, 97.73 -97.03, 6.48 305.14, 104.21 -74.28, 146.89 in-in in 8.685 Saltbr-in 2.725 HRD-in -66.71, -47.33 78.8, -19.85 in-out-out SNCioo out-out ActLoopNT-out 18.689 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -56.48, -29.5 APE9-dihe-na -75.21, -5.78 APE8-dihe-out -116.03, -0.39 APE8-rot-in 294.97 APE67-dihe-in -63.2, -20.28 -68.0, -40.36 APE12-dist-in 10.95 APE11-dist-in 12.547 APE10-dist-out 13.523 APE9-dist-out 10.751 None None None XRAY 1.93 0.187 0.23 D 288 271 3 0 0 3 [[457, 716]] 1.0 7k0v TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6P3DA 448 721 766.0 0LI:61001 Type2 Inactive DFGout 12.35 10.905 BBAminus -138.54, -166.92 -135.05, 80.45 -80.66, -37.84 293.17, 97.28 81.0, 10.25 in-in in 8.665 Saltbr-in 2.997 HRD-in -65.6, -55.77 77.59, -19.55 in-out-out SNCioo out-out ActLoopNT-out 19.945 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -19.82 APE9-dihe-na 76.62, -63.3 APE8-dihe-out -51.89, -23.77 APE8-rot-out 78.9 APE67-dihe-in -55.73, -23.59 -56.01, -24.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.7 APE9-dist-out 11.871 None None None XRAY 2.11 0.188 0.245 A 297 261 13 0 0 13 [[457, 716]] 1.0 6p3d TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6P7GA 449 720 766.0 E7M:801 Type2 Inactive DFGout 12.215 11.891 BBAminus -159.65, -164.2 -127.7, 90.3 -82.38, -7.57 301.17, 86.83 60.88, -78.71 in-in in 8.177 Saltbr-in 2.532 HRD-in -63.47, -53.15 82.99, -13.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -135.97 APE9-dihe-na 134.09, -59.01 APE8-dihe-out -67.41, -14.79 APE8-rot-in 305.65 APE67-dihe-in -66.79, -30.61 -54.99, -26.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.479 APE9-dist-out 10.957 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.65 0.249 0.279 A 297 256 16 0 0 16 [[457, 716]] 1.0 6p7g TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6P7GC 449 721 766.0 E7M:1001 Type2 Inactive DFGout 12.085 11.902 BBAminus -160.21, -162.76 -128.55, 89.81 -81.26, -8.23 299.73, 85.89 54.67, -101.58 in-in in 8.142 Saltbr-in 2.537 HRD-in -62.98, -54.21 81.98, -13.39 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 56.12 APE8-dihe-out -61.58, -13.4 APE8-rot-in 306.31 APE67-dihe-in -67.6, -30.05 -49.64, -29.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.895 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.65 0.249 0.279 C 297 256 17 0 0 17 [[457, 716]] 1.0 6p7g TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6P7GD 449 721 766.0 E7M:801 Type2 Inactive DFGout 12.087 11.766 BBAminus -164.2, -158.89 -130.34, 90.23 -82.14, -3.98 300.53, 97.34 65.59, -81.4 in-in in 8.324 Saltbr-in 2.527 HRD-in -63.14, -53.82 83.11, -14.53 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 64.01 APE9-dihe-na -163.55, 2.06 APE8-dihe-out -71.33, -6.98 APE8-rot-in 296.6 APE67-dihe-in -66.21, -30.46 -50.72, -28.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.342 APE9-dist-out 11.097 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.65 0.249 0.279 D 297 254 19 0 0 16 [[457, 716]] 1.0 6p7g TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
8F7OA 449 723 766.0 QOP:801 Type2 Inactive DFGout 12.249 12.005 BBAminus -159.37, -168.95 -123.81, 84.53 -83.54, -89.81 307.46, 148.61 127.38, -72.17 in-in in 8.972 Saltbr-in 2.449 HRD-in -72.55, -36.43 67.7, -16.13 in-out-out SNCioo out-out ActLoopNT-out 20.564 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na 65.25, -64.98 APE9-dihe-na -63.4, 3.38 APE8-dihe-out -60.69, 15.08 APE8-rot-out 16.0 APE67-dihe-in -61.67, -17.82 -103.11, -29.37 APE12-dist-in 11.837 APE11-dist-in 9.427 APE10-dist-out 14.448 APE9-dist-out 13.325 None None None XRAY 3.54 0.221 0.269 A 283 263 12 0 0 12 [[457, 716]] 1.0 8f7o TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
8F7OB 449 722 766.0 QOP:801 Type2 Inactive DFGout 12.526 11.094 BBAminus -157.64, -171.1 -125.72, 86.17 -82.43, 36.51 307.61, 97.24 -67.66, 176.06 in-in in 8.823 Saltbr-in 2.519 HRD-in -71.26, -35.39 67.81, -16.97 in-out-out SNCioo out-out ActLoopNT-out 13.331 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -143.78, -76.44 APE9-dihe-na -71.8, -5.6 APE8-dihe-out -117.21, 21.56 APE8-rot-in 305.57 APE67-dihe-in -66.7, -20.49 -89.8, -34.59 APE12-dist-out 21.596 APE11-dist-out 24.172 APE10-dist-out 26.848 APE9-dist-out 27.611 None None None XRAY 3.54 0.221 0.269 B 283 263 11 0 0 11 [[457, 716]] 1.0 8f7o TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
8F7PA 449 721 766.0 K81:801 Type2 Inactive DFGout 12.271 11.628 BBAminus -156.68, -164.15 -121.75, 85.43 -84.12, 10.71 303.7, 107.46 -81.06, 134.26 in-in in 8.888 Saltbr-in 3.014 HRD-in -73.5, -44.32 71.2, -9.26 in-out-out SNCioo out-out ActLoopNT-out 18.561 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 33.99 APE8-dihe-out -134.95, 21.55 APE8-rot-in 320.31 APE67-dihe-in -64.87, -22.48 -65.57, -35.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.619 None None None XRAY 2.74 0.216 0.258 A 283 255 18 0 0 14 [[457, 716]] 1.0 8f7p TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
8F7PB 448 721 766.0 K81:801 Type2 Inactive DFGout 12.607 12.007 BBAminus -155.49, -166.94 -122.97, 87.7 -80.57, 10.81 303.23, 78.54 -77.37, 131.38 in-in in 8.787 Saltbr-in 2.438 HRD-in -71.72, -41.08 70.64, -13.43 in-out-out SNCioo out-out ActLoopNT-out 16.028 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -51.39, -20.78 APE9-dihe-na -101.13, 28.63 APE8-dihe-out -146.13, 10.57 APE8-rot-in 318.08 APE67-dihe-in -64.57, -22.2 -69.36, -34.46 APE12-dist-none 999.0 APE11-dist-in 13.018 APE10-dist-out 13.824 APE9-dist-out 10.776 None None None XRAY 2.74 0.216 0.258 B 283 265 9 0 0 6 [[457, 716]] 1.0 8f7p TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4JVGA 448 722 766.0 B96:801 Type2 Inactive DFGout 12.601 12.142 BBAminus -152.0, -179.18 -108.57, 103.11 -89.17, -11.63 297.68, 64.75 -65.51, 135.76 in-in in 8.092 Saltbr-in 2.208 HRD-in -60.98, -42.98 82.63, -9.91 in-out-none SNCion out-none ActLoopNT-out 12.896 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.14 APE8-rot-in 256.63 APE67-dihe-inflip 91.68, -19.72 -68.13, 164.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.09 0.235 0.295 A 284 262 13 0 0 13 [[457, 716]] 1.0 4jvg TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4JVGB 448 722 766.0 B96:801 Type2 Inactive DFGout 12.826 12.184 BBAminus -174.75, 179.41 -102.42, 106.41 -90.9, -4.12 297.49, 49.02 -65.8, 122.16 in-in in 8.459 Saltbr-in 2.71 HRD-in -64.11, -47.16 78.18, -4.98 in-out-out SNCioo out-out ActLoopNT-out 13.769 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -160.08 APE8-rot-out 74.04 APE67-dihe-in -54.93, -35.08 -66.58, -46.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.09 0.235 0.295 B 284 259 16 0 0 16 [[457, 716]] 1.0 4jvg TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4JVGC 448 722 766.0 B96:801 Type2 Inactive DFGout 12.873 11.926 BBAminus -170.55, 179.85 -107.23, 105.54 -90.8, -7.34 293.44, 58.77 -62.12, 118.99 in-in in 8.075 Saltbr-in 3.185 HRD-in -64.29, -46.36 80.05, -5.68 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 172.84 APE8-rot-in 258.15 APE67-dihe-in -55.16, -37.17 -69.96, -40.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.09 0.235 0.295 C 284 258 17 0 0 17 [[457, 716]] 1.0 4jvg TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4JVGD 448 722 766.0 B96:801 Type2 Inactive DFGout 12.516 12.022 BBAminus -150.99, -178.96 -114.25, 104.97 -92.99, -5.76 302.31, 60.74 -58.21, 124.26 in-in in 7.708 Saltbr-in 2.985 HRD-in -62.82, -47.42 78.22, -6.34 in-out-none SNCion out-none ActLoopNT-out 12.749 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 171.09 APE8-rot-in 273.64 APE67-dihe-in -55.99, -27.69 -64.17, -43.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.09 0.235 0.295 D 284 262 13 0 0 13 [[457, 716]] 1.0 4jvg TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6CADA 449 722 766.0 EU4:801 Type2 Inactive DFGout 12.595 11.825 BBAminus -159.24, -179.7 -103.39, 71.59 -75.73, 54.56 304.33, 87.02 -141.23, 999.0 in-in in 8.568 Saltbr-in 2.974 HRD-out -95.68, 91.01 -62.19, -31.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, -44.86 APE9-dihe-na -72.4, -11.01 APE8-dihe-out -124.58, 43.91 APE8-rot-out 63.2 APE67-dihe-in -54.15, -31.66 -63.78, -40.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.376 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.55 0.256 0.277 A 284 249 25 0 0 17 [[457, 716]] 1.0 6cad TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6NSQA 448 722 766.0 KZP:801 Type2 Inactive DFGout 12.902 11.243 BBAminus -166.96, 168.99 -96.91, 86.85 -86.08, -39.02 294.09, 94.9 -83.04, -178.29 in-in in 8.909 Saltbr-in 2.678 HRD-out -92.47, 101.24 -82.61, 157.61 in-out-out SNCioo out-out ActLoopNT-out 14.412 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -67.92, -25.45 APE9-dihe-na -63.86, -33.25 APE8-dihe-out -82.75, 8.97 APE8-rot-out 73.84 APE67-dihe-in -57.79, -36.09 -62.1, -28.45 APE12-dist-out 4.008 APE11-dist-out 6.369 APE10-dist-out 10.097 APE9-dist-out 12.107 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.05 0.237 0.275 A 284 274 1 0 0 1 [[457, 716]] 1.0 6nsq TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
8C7XA 449 721 766.0 TXV:60819 Type2 Inactive DFGout 12.443 11.732 BBAminus -135.27, -175.23 -125.31, 91.5 -84.77, 1.35 298.16, 96.35 -135.3, 38.11 in-in in 8.498 Saltbr-in 2.865 HRD-in -69.83, -48.66 82.13, -14.5 in-out-out SNCioo out-out ActLoopNT-out 14.684 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -57.54, -34.33 APE9-dihe-na -66.65, -4.24 APE8-dihe-out -124.33, -3.25 APE8-rot-in 302.06 APE67-dihe-in -65.06, -18.56 -51.42, -40.3 APE12-dist-in 10.517 APE11-dist-in 10.208 APE10-dist-out 14.036 APE9-dist-out 10.816 None None None XRAY 1.65 0.154 0.171 A 284 273 0 0 0 0 [[457, 716]] 1.0 8c7x TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
8C7XB 448 721 766.0 TXV:60803 Type2 Inactive DFGout 12.319 11.743 BBAminus -141.6, -169.03 -129.23, 87.73 -87.17, -9.74 297.6, 98.29 46.23, -133.22 in-in in 8.467 Saltbr-in 2.726 HRD-in -71.23, -49.45 77.51, -13.46 in-out-out SNCioo out-out ActLoopNT-out 18.117 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -73.7 APE9-dihe-na -64.9, -3.59 APE8-dihe-out -123.65, 0.9 APE8-rot-in 304.25 APE67-dihe-in -68.19, -19.78 -53.41, -37.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.251 APE9-dist-out 10.731 None None None XRAY 1.65 0.154 0.171 B 284 261 13 0 0 13 [[457, 716]] 1.0 8c7x TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4XV9A 448 705 766.0 1OO:60801 Type2 Inactive DFGout 13.008 11.278 BBAminus -160.05, -146.26 -134.54, 69.07 -82.79, -64.14 300.54, 89.49 60.6, 38.5 out-out out 11.04 Saltbr-out 8.75 HRD-in -67.4, -51.3 81.85, -11.8 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -66.79, -18.46 APE9-dihe-na -86.17, 22.53 APE8-dihe-out -132.0, -0.24 APE8-rot-in 286.92 APE67-dihe-in -67.66, -22.33 -58.08, -40.23 APE12-dist-none 999.0 APE11-dist-in 10.793 APE10-dist-out 13.834 APE9-dist-out 10.834 R443S,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R None None XRAY 2.0 0.206 0.238 A 292 244 14 0 0 14 [[457, 716]] 1.0 4xv9 TKL_BRAF_HUMAN TKL 5.3e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5HI2A 449 721 766.0 BAX:801 Type2 Inactive DFGout 12.342 11.652 BBAminus -149.96, -163.11 -123.43, 99.25 -92.3, 0.56 291.37, 69.87 -68.92, 152.82 in-in in 8.093 Saltbr-in 2.759 HRD-in -69.01, -47.24 79.78, -21.21 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 20.66 APE8-rot-in 304.3 APE67-dihe-in -43.41, -33.84 -68.26, -34.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.512 0.191 0.237 A 283 247 21 0 0 18 [[457, 716]] 1.0 5hi2 TKL_BRAF_HUMAN TKL 2.7e-82 282.3 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5HIDA 449 722 766.0 B1E:801 Type2 Inactive DFGout 12.493 12.017 BBAminus -148.05, -170.32 -131.28, 92.62 -86.53, -2.96 298.53, 92.2 -68.79, 146.98 in-in in 8.492 Saltbr-in 2.766 HRD-in -64.1, -45.87 83.74, -14.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -62.68, -30.19 APE9-dihe-na -87.33, 7.43 APE8-dihe-out -130.88, -13.43 APE8-rot-in 296.58 APE67-dihe-in -61.83, -28.04 -56.1, -37.18 APE12-dist-in 11.153 APE11-dist-in 12.543 APE10-dist-out 13.696 APE9-dist-out 11.15 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.5 0.236 0.279 A 283 257 12 0 0 12 [[457, 716]] 1.0 5hid TKL_BRAF_HUMAN TKL 2.7e-82 282.3 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5HIDB 449 722 766.0 B1E:801 Type2 Inactive DFGout 12.159 11.835 BBAminus -150.17, -165.44 -136.1, 98.11 -93.2, 7.71 302.03, 95.62 -74.12, 132.04 in-in in 8.403 Saltbr-in 2.744 HRD-in -63.77, -45.74 86.42, -18.86 in-out-out SNCioo out-out ActLoopNT-out 15.47 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -62.79, -30.35 APE9-dihe-na -86.15, 7.38 APE8-dihe-out -132.43, -14.16 APE8-rot-in 296.5 APE67-dihe-in -61.76, -28.27 -56.26, -37.09 APE12-dist-in 11.765 APE11-dist-in 13.042 APE10-dist-out 14.145 APE9-dist-out 11.066 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.5 0.236 0.279 B 283 269 0 0 0 0 [[457, 716]] 1.0 5hid TKL_BRAF_HUMAN TKL 2.7e-82 282.3 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
1UWJA 448 723 766.0 BAX:61723 Type2 Inactive DFGout 12.472 11.399 BBAminus -166.47, 179.42 -106.43, 75.02 -68.47, 24.79 296.03, 53.21 -94.41, 168.9 in-in in 8.03 Saltbr-in 2.628 HRD-in -71.1, -39.74 67.88, -2.3 in-out-out SNCioo out-out ActLoopNT-out 14.476 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -8.12 APE8-dihe-in -179.1, 96.45 APE8-rot-out 67.95 APE67-dihe-in -46.32, -38.84 -93.37, -26.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.063 V600E None None XRAY 3.5 0.275 0.357 A 276 264 12 0 0 12 [[457, 716]] 1.0 1uwj TKL_BRAF_HUMAN TKL 7.6e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
1UWJB 448 723 766.0 BAX:61723 Type2 Inactive DFGout 12.471 11.42 BBAminus -165.41, 177.79 -106.4, 76.01 -68.12, 23.11 295.71, 53.18 -92.84, 169.18 in-in in 8.023 Saltbr-in 2.55 HRD-in -72.21, -38.76 66.05, -0.46 in-out-out SNCioo out-out ActLoopNT-out 14.414 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -129.57 APE8-dihe-in -120.6, 126.56 APE8-rot-out 201.87 APE67-dihe-in -46.86, -38.56 -98.38, -30.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.281 V600E None None XRAY 3.5 0.275 0.357 B 276 263 13 0 0 13 [[457, 716]] 1.0 1uwj TKL_BRAF_HUMAN TKL 7.6e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6N0PA 449 721 766.0 K81:801 Type2 Inactive DFGout 12.214 11.878 BBAminus -150.84, -166.36 -133.26, 90.72 -86.01, 5.11 312.19, 120.29 -83.35, 143.89 in-in in 8.618 Saltbr-in 2.792 HRD-in -60.05, -51.45 77.42, -10.85 in-out-out SNCioo out-out ActLoopNT-out 13.664 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -167.57, 118.61 APE9-dihe-na -72.7, 74.77 APE8-dihe-out -135.49, 20.32 APE8-rot-in 288.2 APE67-dihe-in -64.39, -23.79 -58.12, -33.58 APE12-dist-out 15.29 APE11-dist-in 12.999 APE10-dist-out 9.621 APE9-dist-out 10.504 None None None XRAY 2.37 0.196 0.233 A 273 268 5 0 0 5 [[457, 716]] 1.0 6n0p TKL_BRAF_HUMAN TKL 7.1e-82 280.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6N0PB 449 721 766.0 K81:801 Type2 Inactive DFGout 12.27 11.601 BBAminus -154.33, -158.54 -140.36, 105.46 -99.62, 9.7 309.45, 119.59 -74.9, 146.92 in-in in 8.476 Saltbr-in 2.793 HRD-in -59.73, -52.44 77.31, -9.83 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 63.33 APE9-dihe-na 137.65, 178.51 APE8-dihe-out 52.67, 41.68 APE8-rot-out 72.23 APE67-dihe-in -63.68, -28.63 -72.48, -21.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.127 APE9-dist-out 9.729 None None None XRAY 2.37 0.196 0.233 B 273 256 17 0 0 15 [[457, 716]] 1.0 6n0p TKL_BRAF_HUMAN TKL 7.1e-82 280.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
8QQGB 448 721 766.0 WJ9:60801 Type2 Inactive DFGout 12.382 12.017 BBAminus -147.64, -162.97 -128.12, 93.85 -88.61, -11.38 305.49, 128.3 -67.77, 148.99 in-in in 8.343 Saltbr-in 2.945 HRD-in -62.34, -52.73 84.22, -12.03 in-out-out SNCioo out-out ActLoopNT-out 14.174 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -85.62, -151.01 APE9-dihe-na 70.57, -172.47 APE8-dihe-in -97.07, 129.86 APE8-rot-in 279.34 APE67-dihe-in -65.5, -31.27 -104.89, -8.68 APE12-dist-none 999.0 APE11-dist-in 13.739 APE10-dist-out 10.992 APE9-dist-out 9.912 None None None XRAY 2.979 0.225 0.261 B 275 262 12 0 0 12 [[457, 716]] 1.0 8qqg TKL_BRAF_HUMAN TKL 7.3e-82 280.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
8QQGC 448 721 766.0 WJ9:60801 Type2 Inactive DFGout 12.154 11.896 BBAminus -150.55, -165.27 -126.65, 93.95 -89.32, -7.92 305.19, 129.14 -67.42, 148.67 in-in in 7.878 Saltbr-in 2.934 HRD-in -64.1, -53.0 82.95, -9.08 in-out-out SNCioo out-out ActLoopNT-out 14.73 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -89.43, -34.97 APE9-dihe-na -79.6, -159.5 APE8-dihe-in -94.88, 131.57 APE8-rot-out 206.31 APE67-dihe-in -66.23, -31.33 -106.98, -10.88 APE12-dist-out 17.968 APE11-dist-out 15.914 APE10-dist-out 10.977 APE9-dist-out 8.683 None None None XRAY 2.979 0.225 0.261 C 275 266 8 0 0 6 [[457, 716]] 1.0 8qqg TKL_BRAF_HUMAN TKL 7.3e-82 280.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5CT7A 449 721 766.0 55J:801 Type2 Inactive DFGout 12.886 11.052 BBAminus -138.5, -161.87 -136.53, 63.32 -70.71, 0.76 307.97, 85.91 -84.3, 147.11 in-in in 7.833 Saltbr-in 2.965 HRD-in -54.99, -43.88 73.11, -9.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 170.28 APE8-dihe-in -118.08, 74.43 APE8-rot-out 47.26 APE67-dihe-in -69.51, -27.98 -64.63, -15.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.883 None None None XRAY 3.17 0.183 0.217 A 281 257 16 0 0 16 [[457, 716]] 1.0 5ct7 TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5VALA 446 720 766.0 92D:801 Type2 Inactive DFGout 12.11 11.911 BBAminus -149.01, -174.68 -126.07, 88.73 -82.22, 0.8 299.36, 118.93 169.17, 999.0 in-in in 8.015 Saltbr-in 2.798 HRD-in -64.34, -52.83 80.65, -12.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 33.61 APE8-rot-out 63.69 APE67-dihe-in -62.38, -27.8 -66.35, -27.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.26 0.183 0.217 A 281 254 21 0 0 19 [[457, 716]] 1.0 5val TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5VALB 448 721 766.0 92D:801 Type2 Inactive DFGout 12.354 11.993 BBAminus -149.26, -173.77 -126.01, 88.92 -82.78, 0.42 299.72, 118.18 52.97, -120.88 in-in in 8.298 Saltbr-in 2.728 HRD-in -64.61, -53.09 81.08, -12.76 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -50.39 APE8-dihe-in -90.0, 76.18 APE8-rot-out 45.23 APE67-dihe-in -62.08, -27.1 -72.62, -25.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.213 None None None XRAY 2.26 0.183 0.217 B 281 254 20 0 0 17 [[457, 716]] 1.0 5val TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5VAMA 449 721 766.0 92J:801 Type2 Inactive DFGout 12.357 11.611 BBAminus -140.58, -169.46 -141.4, 105.48 -100.78, 5.91 303.65, 125.69 -66.9, 143.7 in-in in 8.659 Saltbr-in 2.781 HRD-in -61.66, -53.22 75.75, -7.37 in-out-out SNCioo out-out ActLoopNT-out 16.385 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -116.11, 170.97 APE9-dihe-na 75.01, 10.89 APE8-dihe-out -136.21, 30.89 APE8-rot-in 310.43 APE67-dihe-in -62.28, -24.09 -56.43, -35.95 APE12-dist-out 17.014 APE11-dist-in 12.06 APE10-dist-out 12.944 APE9-dist-out 9.767 None None None XRAY 2.1 0.194 0.223 A 281 269 4 0 0 4 [[457, 716]] 1.0 5vam TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5VAMB 449 721 766.0 92J:801 Type2 Inactive DFGout 12.148 11.53 BBAminus -153.03, -162.76 -138.62, 102.37 -98.12, 14.9 310.11, 121.47 -69.82, 134.27 in-in in 9.125 Saltbr-in 2.782 HRD-in -61.72, -53.8 75.79, -5.73 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 117.24 APE8-dihe-in -95.34, 81.39 APE8-rot-in 346.58 APE67-dihe-in -66.96, -30.47 -72.22, -17.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.178 None None None XRAY 2.1 0.194 0.223 B 281 260 13 0 0 13 [[457, 716]] 1.0 5vam TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6B8UA 449 720 766.0 8EN:801 Type2 Inactive DFGout 12.512 11.898 BBAminus -161.83, -162.08 -129.43, 94.63 -82.19, -3.04 296.13, 79.0 -80.39, 164.52 in-in in 8.689 Saltbr-in 2.829 HRD-in -58.24, -54.19 79.37, -7.03 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -156.99 APE8-dihe-in -124.8, 88.68 APE8-rot-out 60.47 APE67-dihe-in -67.38, -25.35 -78.09, -12.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.404 None None None XRAY 2.68 0.18 0.218 A 281 253 19 0 0 16 [[457, 716]] 1.0 6b8u TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6B8UB 447 720 766.0 8EN:801 Type2 Inactive DFGout 12.531 12.284 BBAminus -160.02, -169.59 -125.27, 94.83 -82.88, 12.14 291.51, 88.01 57.91, 999.0 in-in in 8.375 Saltbr-in 2.77 HRD-in -59.3, -53.28 79.2, -6.72 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -20.81 APE8-rot-in 292.76 APE67-dihe-in -67.06, -25.25 -64.08, -25.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.68 0.18 0.218 B 281 248 26 0 0 19 [[457, 716]] 1.0 6b8u TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6N0QA 446 721 766.0 K7S:801 Type2 Inactive DFGout 12.152 11.976 BBAminus -145.97, -168.83 -131.27, 90.27 -81.9, -25.38 302.79, 126.64 -85.46, 999.0 in-in in 8.219 Saltbr-in 2.76 HRD-in -66.82, -47.88 78.99, -14.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 105.38 APE9-dihe-na -87.38, 57.4 APE8-dihe-out -149.43, 0.41 APE8-rot-out 65.63 APE67-dihe-in -63.4, -24.61 -63.61, -33.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.794 None None None XRAY 2.04 0.182 0.213 A 281 257 19 0 0 17 [[457, 716]] 1.0 6n0q TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6N0QB 448 721 766.0 K7S:801 Type2 Inactive DFGout 12.234 12.096 BBAminus -154.72, -168.56 -126.78, 88.07 -81.57, 1.49 304.84, 119.23 48.5, -147.29 in-in in 8.377 Saltbr-in 2.743 HRD-in -68.08, -48.45 77.62, -16.78 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -71.71 APE8-dihe-in -79.85, 72.37 APE8-rot-out 48.17 APE67-dihe-in -65.78, -27.35 -71.67, -17.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.42 None None None XRAY 2.04 0.182 0.213 B 281 254 20 0 0 17 [[457, 716]] 1.0 6n0q TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3Q96A 449 722 766.0 0NF:1 Type2 Inactive DFGout 12.887 10.676 BBAminus -160.13, -172.44 -118.2, 91.86 -79.01, 12.35 294.04, 84.62 -59.8, 141.31 in-in in 8.392 Saltbr-in 2.855 HRD-in -57.31, -47.78 82.12, -11.82 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -115.71 APE8-rot-in 265.02 APE67-dihe-in -61.58, -24.04 -87.09, -36.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.233 0.288 A 282 253 21 0 0 18 [[457, 716]] 1.0 3q96 TKL_BRAF_HUMAN TKL 8e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3Q96B 449 720 766.0 0NF:1 Type2 Inactive DFGout 12.338 11.655 BBAminus -159.06, -168.23 -117.43, 81.54 -79.68, 17.57 296.0, 82.29 -26.83, 105.54 in-in in 8.586 Saltbr-in 3.176 HRD-in -76.92, -42.58 73.28, -12.97 in-out-out SNCioo out-out ActLoopNT-out 18.49 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 159.44 APE8-dihe-in -92.55, 126.53 APE8-rot-in 290.06 APE67-dihe-in -62.77, -20.3 -102.35, -28.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.232 None None None XRAY 3.1 0.233 0.288 B 282 262 10 0 0 10 [[457, 716]] 1.0 3q96 TKL_BRAF_HUMAN TKL 8e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4DBNA 448 721 766.0 0JA:60901 Type2 Inactive DFGout 12.524 11.592 BBAminus -154.44, -162.66 -150.64, 90.45 -97.41, 13.96 314.34, 97.82 -74.51, 142.3 in-in in 8.345 Saltbr-in 2.831 HRD-in -68.35, -47.82 78.16, -4.01 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 178.62 APE8-dihe-in -127.19, 92.91 APE8-rot-out 54.29 APE67-dihe-in -55.76, -28.27 -65.45, -34.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.512 None None None XRAY 3.15 0.198 0.243 A 284 257 17 0 0 17 [[457, 716]] 1.0 4dbn TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4DBNB 448 720 766.0 0JA:60901 Type2 Inactive DFGout 12.609 11.59 BBAminus -128.03, -174.95 -129.84, 81.69 -87.83, -34.52 305.83, 115.71 70.01, -76.13 in-in in 8.216 Saltbr-in 2.902 HRD-in -63.73, -52.28 81.42, -15.1 in-out-out SNCioo out-out ActLoopNT-out 18.344 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -154.96 APE8-dihe-in -121.29, 96.58 APE8-rot-out 211.52 APE67-dihe-in -67.37, -17.59 -73.93, -38.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.298 None None None XRAY 3.15 0.198 0.243 B 284 263 10 0 0 10 [[457, 716]] 1.0 4dbn TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4FC0A 448 722 766.0 0T2:60901 Type2 Inactive DFGout 12.126 11.586 BBAminus -153.59, -164.38 -132.76, 92.72 -91.26, 26.45 298.08, 84.06 -114.26, 999.0 in-in in 8.796 Saltbr-in 2.697 HRD-in -64.95, -50.81 80.25, -12.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 154.13 APE8-dihe-in -107.59, 65.51 APE8-rot-in 301.84 APE67-dihe-in -60.02, -23.67 -50.91, -43.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.522 None None None XRAY 2.95 0.2 0.243 A 284 254 21 0 0 18 [[457, 716]] 1.0 4fc0 TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4FC0B 448 720 766.0 0T2:60901 Type2 Inactive DFGout 12.239 11.705 BBAminus -154.95, -168.83 -118.03, 93.75 -95.71, 51.36 301.2, 97.17 -51.2, 96.43 in-in in 8.256 Saltbr-in 2.925 HRD-in -64.51, -53.67 78.65, 1.79 in-out-out SNCioo out-out ActLoopNT-out 18.643 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -114.88 APE8-dihe-in -124.62, 102.83 APE8-rot-in 269.89 APE67-dihe-in -59.25, -18.38 -83.24, -36.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.89 None None None XRAY 2.95 0.2 0.243 B 284 263 10 0 0 10 [[457, 716]] 1.0 4fc0 TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4KSPA 448 722 766.0 1SU:60901 Type2 Inactive DFGout 12.838 11.375 BBAminus -149.86, -149.06 -154.88, 90.05 -92.69, 5.43 311.76, 133.96 -47.03, 999.0 in-in in 8.4 Saltbr-in 2.992 HRD-in -71.91, -41.9 72.24, -17.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 169.52 APE8-dihe-in -109.46, 89.69 APE8-rot-in 258.16 APE67-dihe-in -65.67, -26.43 -74.75, -36.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.845 None None None XRAY 2.93 0.197 0.242 A 284 257 18 0 0 18 [[457, 716]] 1.0 4ksp TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4KSPB 448 720 766.0 1SU:60901 Type2 Inactive DFGout 12.257 11.846 BBAminus -174.12, -155.73 -118.56, 108.74 -113.95, 66.59 308.83, 114.94 -51.82, -77.14 in-out in 8.44 Saltbr-out 3.88 HRD-in -64.99, -50.42 81.78, -18.05 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.14 APE8-dihe-in -120.79, 103.17 APE8-rot-in 280.31 APE67-dihe-in -69.23, -21.09 -88.21, -30.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.148 None None None XRAY 2.93 0.197 0.242 B 284 256 17 0 0 17 [[457, 716]] 1.0 4ksp TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4KSQA 448 722 766.0 1SW:60901 Type2 Inactive DFGout 12.7 11.263 BBAminus -139.07, -156.01 -144.98, 102.81 -100.72, 21.0 314.74, 133.71 -88.35, 145.76 in-in in 8.372 Saltbr-in 2.877 HRD-in -64.0, -43.15 74.68, -17.09 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 177.23 APE8-dihe-in -108.75, 103.33 APE8-rot-out 22.61 APE67-dihe-in -67.5, -19.5 -79.7, -29.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 7.836 None None None XRAY 3.3 0.208 0.256 A 284 258 17 0 0 17 [[457, 716]] 1.0 4ksq TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4KSQB 449 720 766.0 1SW:60901 Type2 Inactive DFGout 12.08 11.493 BBAminus -150.55, -156.53 -118.96, 105.53 -118.02, 18.97 306.08, 127.85 -60.37, 126.34 in-in in 8.332 Saltbr-in 2.809 HRD-in -72.57, -35.68 69.22, 0.73 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -48.23 APE8-dihe-in -139.11, 75.84 APE8-rot-in 282.78 APE67-dihe-in -67.26, -25.58 -86.58, -18.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.927 None None None XRAY 3.3 0.208 0.256 B 284 255 17 0 0 17 [[457, 716]] 1.0 4ksq TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3IDPA 449 720 766.0 L1E:2 Type2 Inactive DFGout 12.784 11.643 BBAminus -154.3, -166.43 -118.1, 93.34 -83.15, -5.46 288.88, 80.78 -65.67, 144.09 in-in in 8.476 Saltbr-in 2.797 HRD-in -56.89, -51.61 76.63, -12.91 in-out-out SNCioo out-out ActLoopNT-out 13.943 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -130.04 APE8-dihe-in -103.78, 110.36 APE8-rot-in 306.9 APE67-dihe-in -67.72, -24.2 -82.73, -11.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.893 V600E None None XRAY 2.7 0.206 0.264 A 300 255 17 0 0 15 [[457, 716]] 1.0 3idp TKL_BRAF_HUMAN TKL 1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3IDPB 449 720 766.0 L1E:1 Type2 Inactive DFGout 12.66 12.065 BBAminus -170.28, -168.48 -119.7, 97.43 -90.31, 6.48 291.12, 88.12 -97.93, 157.06 in-in in 8.02 Saltbr-in 2.77 HRD-in -64.31, -45.74 77.59, -13.7 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 27.56 APE9-dihe-na -92.87, 13.62 APE8-dihe-out -117.99, 16.22 APE8-rot-out 50.32 APE67-dihe-in -55.44, -27.24 -54.86, -44.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.914 APE9-dist-out 10.591 V600E None None XRAY 2.7 0.206 0.264 B 300 256 16 0 0 16 [[457, 716]] 1.0 3idp TKL_BRAF_HUMAN TKL 1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4G9RA 448 721 766.0 B1E:801 Type2 Inactive DFGout 12.281 11.51 BBAminus -140.44, -166.78 -124.54, 91.04 -84.58, 2.38 307.85, 108.16 -62.63, 139.55 in-in in 8.807 Saltbr-in 3.043 HRD-in -67.08, -45.9 76.5, -11.17 in-out-out SNCioo out-out ActLoopNT-out 13.601 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 154.29 APE8-dihe-in -88.42, 102.32 APE8-rot-out 32.85 APE67-dihe-in -68.06, -31.95 -78.15, -27.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.034 V600E None None XRAY 3.2 0.229 0.277 A 307 262 12 0 0 12 [[457, 716]] 1.0 4g9r TKL_BRAF_HUMAN TKL 1.1e-81 280.2 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5C9CA 449 720 766.0 4Z5:60900 Type2 Inactive DFGout 12.175 11.99 BBAminus -152.77, -152.03 -130.27, 99.34 -91.23, 12.84 306.39, 96.61 -100.31, 162.73 in-in in 8.656 Saltbr-in 2.707 HRD-in -65.42, -47.95 80.81, -8.16 in-out-out SNCioo out-out ActLoopNT-out 14.134 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 42.04 APE8-rot-out 210.25 APE67-dihe-in -65.15, -19.42 -79.84, -17.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 V600E None None XRAY 2.7 0.196 0.238 A 307 254 18 0 0 16 [[457, 716]] 1.0 5c9c TKL_BRAF_HUMAN TKL 1.1e-81 280.2 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5C9CB 449 720 766.0 4Z5:60801 Type2 Inactive DFGout 12.2 12.241 BBAminus -164.91, -156.21 -132.52, 106.2 -105.64, 12.12 297.13, 98.22 -118.65, 173.79 in-in in 8.611 Saltbr-in 2.75 HRD-in -71.76, -43.74 73.35, -12.16 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 165.69 APE8-rot-in 273.18 APE67-dihe-in -53.48, -28.51 -70.47, -29.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 V600E None None XRAY 2.7 0.196 0.238 B 307 251 21 0 0 18 [[457, 716]] 1.0 5c9c TKL_BRAF_HUMAN TKL 1.1e-81 280.2 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
1UWHA 448 723 766.0 BAX:61723 Type2 Inactive DFGout 12.495 11.481 BBAminus -173.91, -166.78 -121.32, 89.16 -83.23, 16.41 301.34, 66.03 -83.78, 148.03 in-in in 8.456 Saltbr-in 2.989 HRD-in -65.62, -55.23 80.22, -7.91 in-out-out SNCioo out-out ActLoopNT-out 14.57 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -61.57, 175.06 APE9-dihe-na 174.29, 130.89 APE8-dihe-in -93.46, 78.64 APE8-rot-out 46.11 APE67-dihe-in -63.44, -27.03 -60.72, -32.82 APE12-dist-none 999.0 APE11-dist-in 11.595 APE10-dist-out 8.374 APE9-dist-out 8.656 None None None XRAY 2.95 0.222 0.257 A 276 264 12 0 0 12 [[457, 716]] 1.0 1uwh TKL_BRAF_HUMAN TKL 1.8e-81 279.5 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
1UWHB 448 723 766.0 BAX:61723 Type2 Inactive DFGout 12.495 11.491 BBAminus -173.56, -167.09 -121.29, 88.77 -83.17, 16.44 301.44, 65.99 -83.54, 148.34 in-in in 8.438 Saltbr-in 2.963 HRD-in -65.94, -55.1 80.05, -8.58 in-out-out SNCioo out-out ActLoopNT-out 14.988 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -54.44, 165.53 APE9-dihe-na -176.68, 134.04 APE8-dihe-in -91.08, 81.56 APE8-rot-out 44.97 APE67-dihe-in -53.91, -27.06 -61.59, -40.98 APE12-dist-none 999.0 APE11-dist-in 11.198 APE10-dist-out 8.711 APE9-dist-out 9.032 None None None XRAY 2.95 0.222 0.257 B 276 264 12 0 0 12 [[457, 716]] 1.0 1uwh TKL_BRAF_HUMAN TKL 1.8e-81 279.5 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3II5A 448 720 766.0 831:60001 Type2 Inactive DFGout 12.301 11.496 BBAminus -155.57, -166.63 -127.64, 99.56 -98.31, 13.93 306.98, 120.6 -79.68, 131.63 in-in in 9.106 Saltbr-in 3.018 HRD-in -60.69, -56.02 84.38, -6.21 in-out-out SNCioo out-out ActLoopNT-out 13.961 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -120.26, -83.23 APE9-dihe-na 113.98, 136.9 APE8-dihe-in -101.61, 115.55 APE8-rot-out 202.45 APE67-dihe-in -63.73, -30.08 -83.87, -5.58 APE12-dist-in 13.239 APE11-dist-in 8.684 APE10-dist-out 10.766 APE9-dist-out 7.853 None None None XRAY 2.79 0.209 0.251 A 306 262 11 0 0 11 [[457, 716]] 1.0 3ii5 TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3II5B 449 721 766.0 831:60001 Type2 Inactive DFGout 12.443 11.441 BBAminus -134.74, -174.76 -130.73, 93.7 -95.95, 18.9 313.23, 121.08 -68.68, 112.3 in-in in 8.876 Saltbr-in 2.72 HRD-in -72.77, -40.04 68.53, -1.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -10.56 APE8-dihe-in -115.75, 77.93 APE8-rot-in 273.36 APE67-dihe-in -56.24, -18.59 -62.57, -41.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.731 None None None XRAY 2.79 0.209 0.251 B 306 257 16 0 0 16 [[457, 716]] 1.0 3ii5 TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4G9CA 448 723 766.0 0WP:801 Type2 Inactive DFGout 12.323 11.957 BBAminus -161.79, -178.1 -114.62, 68.22 -59.97, -23.71 305.31, 100.52 75.79, -130.3 in-in in 8.462 Saltbr-in 2.898 HRD-in -82.65, -45.05 76.52, 0.21 in-out-out SNCioo out-out ActLoopNT-out 18.943 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -63.56, -116.68 APE9-dihe-na 141.17, 171.61 APE8-dihe-in -108.81, 106.37 APE8-rot-in 322.97 APE67-dihe-in -54.58, -37.58 -76.8, -42.56 APE12-dist-none 999.0 APE11-dist-out 14.198 APE10-dist-out 11.022 APE9-dist-out 8.852 None None None XRAY 3.5 0.262 0.291 A 307 265 11 0 0 11 [[457, 716]] 1.0 4g9c TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4G9CB 448 723 766.0 0WP:801 Type2 Inactive DFGout 12.372 11.675 BBAminus -162.63, -177.84 -114.09, 70.68 -59.01, -42.42 300.41, 107.75 -27.19, 128.65 in-in in 8.505 Saltbr-in 2.914 HRD-in -80.74, -47.08 78.89, -0.43 in-out-out SNCioo out-out ActLoopNT-out 16.551 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -65.14, -116.41 APE9-dihe-na 140.87, 171.82 APE8-dihe-in -109.02, 105.11 APE8-rot-in 323.76 APE67-dihe-in -55.25, -37.4 -76.81, -41.18 APE12-dist-none 999.0 APE11-dist-in 13.621 APE10-dist-out 11.737 APE9-dist-out 8.869 None None None XRAY 3.5 0.262 0.291 B 307 264 12 0 0 12 [[457, 716]] 1.0 4g9c TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6P7GB 449 721 766.0 E7M:801,NHE:802 Type2,Allosteric Inactive DFGout 12.213 11.607 BBAminus -161.83, -162.67 -128.78, 90.51 -86.35, -51.52 303.99, 97.12 26.26, 73.75 in-in in 8.25 Saltbr-in 2.536 HRD-in -62.65, -53.67 83.64, -15.67 in-out-out SNCioo out-out ActLoopNT-out 21.235 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -80.82, -17.55 APE9-dihe-na -132.56, -84.95 APE8-dihe-out -42.28, -25.63 APE8-rot-in 319.56 APE67-dihe-in -73.22, -25.37 -56.64, -24.48 APE12-dist-in 12.581 APE11-dist-out 14.229 APE10-dist-out 10.095 APE9-dist-out 10.776 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.65 0.249 0.279 B 297 273 0 0 0 0 [[457, 716]] 1.0 6p7g TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4RZWA 448 720 766.0 B1E:801 Type1 Inactive DFGout 12.982 11.639 None -156.36, -171.72 -123.23, 113.58 -116.17, 177.63 318.28, 100.74 -121.26, 999.0 in-in in 8.374 Saltbr-in 2.791 HRD-in -73.4, -48.32 68.37, -5.73 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 16.65 APE8-dihe-in -104.01, 112.39 APE8-rot-in 337.69 APE67-dihe-in -68.56, -25.59 -122.97, -37.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.887 R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.493 0.248 0.28 A 281 251 22 0 0 18 [[457, 716]] 1.0 4rzw TKL_BRAF_HUMAN TKL 7.2e-84 287.4 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
3C4CB 448 721 766.0 324:60003 Type1.5_Back Inactive DFGout 17.121 11.474 None -158.07, 167.38 -86.45, 172.73 27.7, 999.0 226.78, 93.67 999.0, 999.0 in-out in 9.671 Saltbr-out 7.076 HRD-in -64.15, -34.82 70.63, -1.96 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 56.1 APE9-dihe-na 175.12, 83.72 APE8-dihe-in -104.65, 152.29 APE8-rot-in 256.49 APE67-dihe-in -58.95, -27.9 -70.54, -27.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.729 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 2.57 0.261 0.303 B 280 256 18 0 0 18 [[457, 716]] 1.0 3c4c TKL_BRAF_HUMAN TKL 4.5e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4RZWB 448 721 766.0 B1E:801 Type2 Inactive DFGout 12.777 11.345 None -156.46, -173.05 -125.91, 116.19 -115.01, 999.0 318.43, 102.28 999.0, 999.0 in-in in 8.698 Saltbr-in 2.594 HRD-in -72.06, -47.23 69.11, -4.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 173.84 APE8-dihe-in -101.6, 117.12 APE8-rot-in 296.77 APE67-dihe-in -61.72, -26.32 -116.4, -11.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.268 R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.493 0.248 0.28 B 281 252 22 0 0 19 [[457, 716]] 1.0 4rzw TKL_BRAF_HUMAN TKL 7.2e-84 287.4 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6CADB 449 721 766.0 EU4:801 Type2 Inactive DFGout 12.662 12.132 None -160.15, -178.54 -102.61, 71.13 -75.43, 999.0 305.36, 107.93 999.0, 999.0 in-in in 9.177 Saltbr-in 2.868 HRD-out -93.08, 91.91 -61.44, -31.11 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, -45.98 APE9-dihe-na 97.43, -17.05 APE8-dihe-out -130.37, 38.81 APE8-rot-out 60.99 APE67-dihe-in -57.79, -30.41 -66.2, -46.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.938 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.55 0.256 0.277 B 284 248 25 0 0 18 [[457, 716]] 1.0 6cad TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6NSQB 447 722 766.0 KZP:801 Type2 Inactive DFGout 12.875 11.101 None -166.73, 169.09 -97.13, 87.27 -86.05, 168.9 293.43, 85.03 -83.41, 999.0 in-in in 9.027 Saltbr-in 2.429 HRD-out -91.78, 102.77 -82.81, 156.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -34.39 APE8-dihe-out -84.15, 8.29 APE8-rot-out 179.63 APE67-dihe-in -56.54, -36.36 -64.17, -26.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.775 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.05 0.237 0.275 B 284 253 23 0 0 18 [[457, 716]] 1.0 6nsq TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
8QQGA 449 722 766.0 WJ9:60801 Type2 Inactive DFGout 12.472 11.969 None -151.57, -162.48 -133.16, 90.66 -89.77, 999.0 301.2, 128.17 999.0, 999.0 in-in in 8.016 Saltbr-in 2.939 HRD-in -63.61, -53.7 83.78, -13.79 in-out-out SNCioo out-out ActLoopNT-out 19.241 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -92.3, -36.41 APE9-dihe-na -80.62, -156.71 APE8-dihe-in -88.56, 123.78 APE8-rot-in 289.2 APE67-dihe-in -66.04, -32.02 -104.4, -18.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.105 None None None XRAY 2.979 0.225 0.261 A 275 269 5 0 0 3 [[457, 716]] 1.0 8qqg TKL_BRAF_HUMAN TKL 7.3e-82 280.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
5CT7B 449 721 766.0 55J:801 Type2 Inactive DFGout 13.038 11.219 None -137.4, -162.96 -136.57, 63.11 -71.61, 999.0 306.68, 86.17 999.0, 999.0 in-in in 7.777 Saltbr-in 2.976 HRD-in -56.61, -40.43 63.81, 0.34 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 168.65 APE8-dihe-in -118.54, 73.49 APE8-rot-out 48.75 APE67-dihe-in -70.66, -26.63 -65.01, -15.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.198 None None None XRAY 3.17 0.183 0.217 B 281 254 19 0 0 19 [[457, 716]] 1.0 5ct7 TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
8VYPC 363 733 766.0 AGS:801 ATPlike Inactive None 999.0 999.0 None 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 8.998 Saltbr-out 6.594 HRD-in -95.64, -57.28 53.13, 41.02 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 V600E SEP365,SEP729 SEP365,SEP729 EM 3.29 999.0 999.0 C 767 171 110 0 0 30 [[457, 716]] 1.0 8vyp TKL_BRAF_HUMAN TKL 1.3e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
8VYRA 361 736 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-none in 8.202 Saltbr-none 999.0 HRD-in -72.99, -54.08 72.8, -14.1 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -3.13 APE8-rot-none 999.0 APE67-dihe-in -78.78, -23.88 -52.18, -42.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 V600E SEP365,SEP729 SEP365,SEP729 EM 4.32 999.0 999.0 A 767 235 56 0 0 22 [[457, 716]] 1.0 8vyr TKL_BRAF_HUMAN TKL 1.3e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7ZR0K 521 724 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None -147.96, -165.47 -131.21, -25.27 -43.61, 121.0 28.34, 64.52 -164.96, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -123.64, -31.16 73.6, -12.81 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 152.74 APE8-dihe-out -135.59, 42.49 APE8-rot-out 92.4 APE67-dihe-in -103.42, -12.96 -90.89, 11.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.747 None None None EM 3.4 999.0 999.0 K 828 186 82 0 0 18 [[457, 716]] 1.0 7zr0 TKL_BRAF_HUMAN TKL 1.5e-80 276.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7ZR5K 521 724 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None -142.68, 170.56 -118.72, -1.17 -61.64, 141.86 74.36, 104.13 -173.91, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.18, -30.56 72.36, -16.41 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 76.96 APE8-dihe-out -138.42, 28.65 APE8-rot-out 67.46 APE67-dihe-in -98.65, -24.43 -90.46, 11.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.779 None None None EM 3.9 999.0 999.0 K 828 186 82 0 0 18 [[457, 716]] 1.0 7zr5 TKL_BRAF_HUMAN TKL 1.5e-80 276.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
7ZR6K 521 724 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None -98.5, 171.19 -129.29, -36.65 -81.13, 151.47 63.73, 90.42 -79.12, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -116.13, -33.15 67.35, -9.25 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -36.72 APE8-dihe-out -120.28, 26.45 APE8-rot-out 68.06 APE67-dihe-in -122.37, 11.39 -67.64, -22.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.453 None None None EM 4.2 999.0 999.0 K 828 186 82 0 0 18 [[457, 716]] 1.0 7zr6 TKL_BRAF_HUMAN TKL 1.5e-80 276.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6Q0JA 449 733 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None -125.75, -157.37 46.77, 85.74 -102.95, 25.57 999.0, 999.0 -59.98, -20.53 in-none in 8.812 Saltbr-none 999.0 HRD-in -72.62, -45.55 71.04, -1.27 none-in-out SNCnio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioi APE10-dihe-na -136.58, 156.58 APE9-dihe-na 140.45, 169.19 APE8-dihe-in -83.63, 130.47 APE8-rot-none 999.0 APE67-dihe-in -60.99, -19.46 -69.8, -34.98 APE12-dist-in 12.005 APE11-dist-in 11.471 APE10-dist-out 8.112 APE9-dist-in 5.608 S365A SEP729 SEP729 EM 4.9 999.0 999.0 A 805 281 4 0 0 0 [[457, 716]] 1.0 6q0j TKL_BRAF_HUMAN TKL 1.4e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6Q0JB 449 734 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None -125.77, -157.3 46.62, 85.83 -103.01, 25.5 999.0, 999.0 -59.84, -20.56 in-none in 8.812 Saltbr-none 999.0 HRD-in -72.72, -45.58 70.9, -1.18 none-in-out SNCnio in-out ActLoopNT-in 2.865 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioi APE10-dihe-na -136.54, 156.42 APE9-dihe-na 140.6, 169.11 APE8-dihe-in -83.47, 130.71 APE8-rot-none 999.0 APE67-dihe-in -60.7, -19.7 -69.93, -35.05 APE12-dist-in 12.006 APE11-dist-in 11.471 APE10-dist-out 8.112 APE9-dist-in 5.607 S365A SEP729 SEP729 EM 4.9 999.0 999.0 B 805 282 4 0 0 0 [[457, 716]] 1.0 6q0j TKL_BRAF_HUMAN TKL 1.4e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6Q0TA 449 732 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None -125.68, -157.44 46.86, 85.51 -102.96, 25.68 999.0, 999.0 -59.84, -20.53 in-none in 8.812 Saltbr-none 999.0 HRD-in -72.53, -45.64 70.89, -1.18 none-in-out SNCnio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioi APE10-dihe-na -136.48, 156.68 APE9-dihe-na 140.41, 169.16 APE8-dihe-in -83.57, 130.55 APE8-rot-none 999.0 APE67-dihe-in -60.84, -19.83 -69.97, -34.72 APE12-dist-in 12.006 APE11-dist-in 11.472 APE10-dist-out 8.113 APE9-dist-in 5.61 S365A SEP729 SEP729 EM 5.7 999.0 999.0 A 805 280 4 0 0 0 [[457, 716]] 1.0 6q0t TKL_BRAF_HUMAN TKL 1.4e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6Q0TB 449 730 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None -125.71, -157.51 46.95, 85.47 -102.88, 25.78 999.0, 999.0 -60.15, -20.42 in-none in 8.813 Saltbr-none 999.0 HRD-in -72.6, -45.69 70.98, -1.32 none-in-out SNCnio in-out ActLoopNT-in 2.863 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioi APE10-dihe-na -136.41, 156.62 APE9-dihe-na 140.41, 169.2 APE8-dihe-in -83.59, 130.6 APE8-rot-none 999.0 APE67-dihe-in -60.82, -19.75 -69.88, -34.94 APE12-dist-in 12.003 APE11-dist-in 11.471 APE10-dist-out 8.113 APE9-dist-in 5.609 S365A SEP729 SEP729 EM 5.7 999.0 999.0 B 805 278 4 0 0 0 [[457, 716]] 1.0 6q0t TKL_BRAF_HUMAN TKL 1.4e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6Q0KA 449 737 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None -125.65, -157.35 46.68, 85.84 -103.11, 25.65 999.0, 999.0 -59.88, -20.67 in-none in 8.817 Saltbr-none 999.0 HRD-in -72.59, -45.63 71.09, -1.3 none-in-out SNCnio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioi APE10-dihe-na -136.56, 156.53 APE9-dihe-na 140.45, 169.15 APE8-dihe-in -83.59, 130.49 APE8-rot-none 999.0 APE67-dihe-in -60.96, -19.48 -69.78, -35.01 APE12-dist-in 12.005 APE11-dist-in 11.47 APE10-dist-out 8.113 APE9-dist-in 5.608 None SEP729 SEP729 EM 6.8 999.0 999.0 A 805 285 4 0 0 0 [[457, 716]] 1.0 6q0k TKL_BRAF_HUMAN TKL 1.4e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
6Q0KB 449 733 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None -125.68, -157.33 46.68, 85.75 -103.02, 25.67 999.0, 999.0 -59.95, -20.61 in-none in 8.816 Saltbr-none 999.0 HRD-in -72.72, -45.54 70.99, -1.15 none-in-out SNCnio in-out ActLoopNT-in 2.863 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioi APE10-dihe-na -136.64, 156.57 APE9-dihe-na 140.44, 169.17 APE8-dihe-in -83.6, 130.41 APE8-rot-none 999.0 APE67-dihe-in -60.93, -19.46 -69.77, -35.05 APE12-dist-in 12.006 APE11-dist-in 11.471 APE10-dist-out 8.112 APE9-dist-in 5.609 None SEP729 SEP729 EM 6.8 999.0 999.0 B 805 281 4 0 0 0 [[457, 716]] 1.0 6q0k TKL_BRAF_HUMAN TKL 1.4e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
8VYVC 362 733 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-none in 8.58 Saltbr-none 999.0 HRD-in -70.11, -50.02 76.69, -10.1 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 142.8 APE8-rot-none 999.0 APE67-dihe-in -62.43, -28.28 -57.02, -49.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K601E SEP365,SEP729 SEP365,SEP729 EM 5.86 999.0 999.0 C 767 178 92 0 0 24 [[457, 716]] 1.0 8vyv TKL_BRAF_HUMAN TKL 2.4e-80 276.1 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
4MNFA 449 720 766.0 29L:801 Type1 None DFGin 6.831 14.084 BLAminus -138.14, -173.65 64.87, 78.28 -102.21, 29.93 290.33, 73.26 -66.38, -51.46 in-in in 8.582 Saltbr-in 2.768 HRD-in -70.14, -50.01 76.68, -10.07 in-in-none SNCiin in-none ActLoopNT-in 2.834 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 142.76 APE8-rot-in 296.87 APE67-dihe-in -62.48, -28.21 -57.0, -49.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 V600E None None XRAY 2.802 0.215 0.275 A 329 257 15 0 0 15 [[457, 716]] 1.0 4mnf TKL_BRAF_HUMAN TKL 1.4e-81 279.9 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf

TKL_BRAF (Serine/threonine-protein kinase B-raf)

Total number of chains: 218
Active chains: 4
Family: TKL
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 73 33.5% 8C7YA
DFGin BLAplus 41 18.8% 9BP8A
DFGin BLAminus 39 17.9% AF-P15056-K1A
DFGin BLBplus 20 9.2% 7M0XA
DFGin BLBminus 13 6.0% 7P3VB
None None 12 5.5% 6Q0JA
DFGin None 11 5.0% 4MBJB
DFGout None 7 3.2% 8QQGA
DFGin ABAminus 2 0.9% 4H58B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
BRAF_HUMAN AF-P15056-K1A P15056 449 724 766.0 No_ligand No_ligand Active DFGin 6.578 14.002 BLAminus -136.42, -168.61 54.52, 78.24 -91.38, 15.3 291.45, 90.84 -61.05, -27.93 in-in in 8.73 Saltbr-in 2.806 HRD-in -73.46, -42.74 68.11, -17.22 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.87, 119.19 APE9-dihe-na 120.45, -176.86 APE8-dihe-in -87.87, 116.2 APE8-rot-in 298.87 APE67-dihe-in -55.14, -36.76 -47.67, -38.83 APE12-dist-in 12.648 APE11-dist-in 12.303 APE10-dist-in 6.871 APE9-dist-in 5.7 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[457, 716]] 1.0 AF-P15056-K1 Homo sapiens TKL_BRAF_HUMAN TKL 7.4e-82 280.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN AF-P15056-K3A P15056 449 724 766.0 No_ligand No_ligand Active DFGin 6.489 13.906 BLAminus -136.13, -161.95 56.79, 58.46 -83.12, 17.87 298.48, 102.52 -58.43, -33.8 in-in in 7.988 Saltbr-in 2.695 HRD-in -75.87, -39.62 66.63, -12.61 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.1, 139.45 APE9-dihe-na 110.12, -162.95 APE8-dihe-in -111.8, 115.95 APE8-rot-in 306.17 APE67-dihe-in -66.26, -25.72 -56.57, -34.14 APE12-dist-in 11.842 APE11-dist-in 12.109 APE10-dist-in 6.41 APE9-dist-in 4.023 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[457, 716]] 1.0 AF-P15056-K3 Homo sapiens TKL_BRAF_HUMAN TKL 7.4e-82 280.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4MNEC P15056 449 720 766.0 No_ligand No_ligand Active DFGin 6.31 14.127 BLAminus -116.31, -150.46 30.76, 90.61 -104.11, 27.82 277.24, 67.68 -70.79, -9.9 in-in in 8.744 Saltbr-in 2.439 HRD-in -70.5, -40.5 60.78, 9.72 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.23, 133.86 APE9-dihe-na 149.56, -167.49 APE8-dihe-in -112.25, 121.13 APE8-rot-in 303.71 APE67-dihe-in -62.07, -20.02 -56.34, -38.04 APE12-dist-in 12.159 APE11-dist-in 11.556 APE10-dist-in 7.51 APE9-dist-in 5.815 None None None XRAY 2.848 0.186 0.24 C 308 260 12 0 0 7 [[457, 716]] 1.0 4mne Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4MNEF P15056 449 721 766.0 No_ligand No_ligand Active DFGin 6.476 13.745 BLAminus -130.3, -157.72 45.09, 83.38 -99.59, 25.57 282.18, 62.71 -60.3, -26.4 in-in in 8.685 Saltbr-in 2.75 HRD-in -78.22, -41.28 65.37, 2.99 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.88, 144.35 APE9-dihe-na 131.47, -165.54 APE8-dihe-in -107.46, 126.01 APE8-rot-in 299.7 APE67-dihe-in -57.35, -35.84 -68.63, -28.44 APE12-dist-in 12.528 APE11-dist-in 11.988 APE10-dist-in 7.516 APE9-dist-in 5.875 None None None XRAY 2.848 0.186 0.24 F 308 258 15 0 0 9 [[457, 716]] 1.0 4mne Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4H58B P15056 448 722 766.0 No_ligand No_ligand Inactive DFGin 6.84 14.824 ABAminus -98.82, -88.13 -93.34, 121.12 -119.32, 28.65 302.28, 124.2 -55.88, -57.22 in-in in 8.27 Saltbr-in 3.392 HRD-in -67.57, -56.11 87.58, -17.44 in-in-out SNCiio in-out ActLoopNT-in 3.02 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na 58.08, 30.11 APE9-dihe-na 109.46, 38.41 APE8-dihe-out -130.74, 22.57 APE8-rot-in 295.42 APE67-dihe-in -65.56, -25.13 -73.36, -24.11 APE12-dist-none 999.0 APE11-dist-out 14.043 APE10-dist-out 13.463 APE9-dist-out 11.108 None None None XRAY 3.1 0.224 0.272 B 275 262 13 0 0 13 [[457, 716]] 1.0 4h58 Homo sapiens TKL_BRAF_HUMAN TKL 7.3e-82 280.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3PRFA P15056 448 723 766.0 FP3:727 Type1 Inactive DFGin 6.396 13.706 ABAminus -158.36, 65.71 -149.53, 120.08 -122.92, 49.77 297.22, 87.28 -80.96, 85.15 in-in in 8.203 Saltbr-in 2.752 HRD-in -72.88, -40.09 60.57, 12.2 in-out-out SNCioo out-out ActLoopNT-out 5.394 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 128.3 APE8-dihe-in -99.37, 109.81 APE8-rot-out 47.4 APE67-dihe-out 95.65, -37.23 -70.26, -89.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.293 None None None XRAY 2.9 0.271 0.31 A 307 262 14 0 0 14 [[457, 716]] 1.0 3prf Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 9AXXB P15056 449 721 766.0 ANP:60801 ATPlike Inactive DFGin 6.272 14.156 BLAminus -118.96, -160.68 44.13, 79.21 -91.3, 29.71 285.28, 70.2 -64.85, -24.03 in-out in 8.968 Saltbr-out 6.042 HRD-in -74.42, -44.59 66.93, 5.21 out-in-in SNCoii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.1, 120.32 APE9-dihe-na 137.74, -165.97 APE8-dihe-in -102.01, 122.38 APE8-rot-in 304.65 APE67-dihe-in -63.13, -30.61 -66.04, -26.1 APE12-dist-in 13.099 APE11-dist-in 12.628 APE10-dist-in 7.472 APE9-dist-in 5.708 None None None XRAY 2.07 0.215 0.248 B 280 261 12 0 0 6 [[457, 716]] 1.0 9axx Homo sapiens TKL_BRAF_HUMAN TKL 7.8e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4XV1B P15056 449 705 766.0 No_ligand No_ligand Inactive DFGin 6.294 14.61 BLAminus -145.75, -149.46 45.86, 66.44 -86.18, 28.57 259.03, 77.6 -56.14, -27.52 in-out in 8.843 Saltbr-out 4.117 HRD-in -70.86, -48.46 69.69, 2.81 out-in-none SNCoin in-none ActLoopNT-in 3.027 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -2.07 APE8-rot-in 300.39 APE67-dihe-in -68.18, -18.6 -56.02, -38.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R None None XRAY 2.47 0.236 0.273 B 292 233 24 0 0 15 [[457, 716]] 1.0 4xv1 Homo sapiens TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6XAGC P15056 449 732 766.0 No_ligand No_ligand Inactive DFGin 6.514 14.119 BLAminus -135.38, 176.92 64.87, 80.23 -95.35, 23.32 284.06, 65.51 -66.44, -29.75 in-in in 8.966 Saltbr-in 2.407 HRD-in -79.02, -38.34 63.13, 1.72 in-in-out SNCiio in-out ActLoopNT-in 2.912 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -34.9 APE8-dihe-in -75.72, 91.46 APE8-rot-out 85.17 APE67-dihe-in -63.91, -36.72 -120.11, -4.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.233 None SEP729 SEP729 XRAY 3.3 0.252 0.3 C 290 276 8 0 0 7 [[457, 716]] 1.0 6xag Homo sapiens TKL_BRAF_HUMAN TKL 5.2e-84 287.9 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6XAGD P15056 448 733 766.0 No_ligand No_ligand Inactive DFGin 6.503 13.633 BLAminus -140.73, -174.41 58.18, 74.07 -91.48, 27.0 290.75, 52.26 -65.73, -26.35 in-in in 8.956 Saltbr-in 2.598 HRD-in -81.24, -40.38 63.54, 1.85 in-in-out SNCiio in-out ActLoopNT-in 2.803 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na 58.02, -132.89 APE9-dihe-na -103.64, -7.92 APE8-dihe-in -77.52, 80.03 APE8-rot-out 82.48 APE67-dihe-in -75.94, -11.64 -83.69, -22.48 APE12-dist-none 999.0 APE11-dist-in 9.313 APE10-dist-out 10.954 APE9-dist-out 10.923 None SEP729 SEP729 XRAY 3.3 0.252 0.3 D 290 278 8 0 0 5 [[457, 716]] 1.0 6xag Homo sapiens TKL_BRAF_HUMAN TKL 5.2e-84 287.9 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 9AXXD P15056 449 720 766.0 No_ligand No_ligand Inactive DFGin 6.384 14.198 BLAminus -129.89, -173.73 62.98, 88.51 -109.58, 28.81 291.63, 88.61 -59.73, -40.17 in-in in 8.176 Saltbr-in 2.745 HRD-in -72.62, -47.14 70.14, -3.87 in-in-out SNCiio in-out ActLoopNT-in 2.848 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -147.43, 156.79 APE9-dihe-na -104.74, -133.5 APE8-dihe-in -87.21, 139.54 APE8-rot-in 302.48 APE67-dihe-in -63.49, -37.11 -65.97, -35.07 APE12-dist-in 10.401 APE11-dist-out 6.024 APE10-dist-out 9.101 APE9-dist-in 4.67 None None None XRAY 2.07 0.215 0.248 D 280 272 0 0 0 0 [[457, 716]] 1.0 9axx Homo sapiens TKL_BRAF_HUMAN TKL 7.8e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3Q4CB P15056 448 723 766.0 No_ligand No_ligand Inactive DFGin 6.545 14.559 BLAminus -146.12, -159.83 35.91, 93.44 -110.83, 27.67 289.71, 99.42 -62.68, -9.95 in-in in 8.148 Saltbr-in 3.051 HRD-in -70.95, -56.96 74.51, 13.37 in-in-out SNCiio in-out ActLoopNT-in 2.87 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 84.43 APE9-dihe-na -83.51, 57.43 APE8-dihe-in -129.0, 61.86 APE8-rot-out 58.54 APE67-dihe-in -58.42, -27.85 -82.03, -13.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.208 APE9-dist-out 10.973 None None None XRAY 3.2 0.232 0.28 B 307 264 12 0 0 12 [[457, 716]] 1.0 3q4c Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4MNEB P15056 449 722 766.0 No_ligand No_ligand Inactive DFGin 6.382 14.165 BLAminus -125.74, -157.34 46.68, 85.76 -102.98, 25.57 282.33, 63.28 -59.91, -20.47 in-in in 8.812 Saltbr-in 3.014 HRD-in -72.72, -45.6 70.84, -1.11 in-in-out SNCiio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -136.48, 156.53 APE9-dihe-na 140.48, 169.17 APE8-dihe-in -83.53, 130.6 APE8-rot-in 280.97 APE67-dihe-in -60.93, -19.54 -69.93, -34.89 APE12-dist-in 12.006 APE11-dist-in 11.471 APE10-dist-out 8.112 APE9-dist-in 5.607 None None None XRAY 2.848 0.186 0.24 B 308 270 4 0 0 0 [[457, 716]] 1.0 4mne Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4MNEG P15056 449 720 766.0 No_ligand No_ligand Inactive DFGin 6.351 14.005 BLAminus -133.48, -159.53 39.44, 81.15 -97.21, 35.04 282.93, 67.03 -73.28, -12.15 in-in in 8.979 Saltbr-in 2.571 HRD-in -72.6, -50.8 70.28, 6.2 in-in-out SNCiio in-out ActLoopNT-in 2.881 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -151.59, 152.98 APE9-dihe-na 137.55, -171.6 APE8-dihe-in -109.27, 119.72 APE8-rot-in 306.4 APE67-dihe-in -64.78, -21.88 -56.06, -36.62 APE12-dist-in 12.029 APE11-dist-in 11.478 APE10-dist-out 8.056 APE9-dist-in 5.674 None None None XRAY 2.848 0.186 0.24 G 308 259 13 0 0 8 [[457, 716]] 1.0 4mne Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6UANC P15056 449 733 766.0 No_ligand No_ligand Inactive DFGin 6.722 15.086 BLAminus -133.66, -145.42 58.01, 67.46 -89.23, 29.8 285.54, 141.38 -68.94, -15.87 in-out in 9.453 Saltbr-out 5.351 HRD-out -71.43, 94.34 -71.05, -36.25 out-in-out SNCoio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioo APE10-dihe-na -159.48, 168.73 APE9-dihe-na -90.57, 11.03 APE8-dihe-in -91.34, 50.74 APE8-rot-none 999.0 APE67-dihe-in -76.53, -9.36 -80.03, -36.5 APE12-dist-in 13.374 APE11-dist-in 12.637 APE10-dist-out 10.006 APE9-dist-out 11.619 T373C,I374M SEP729 SEP729 EM 3.9 999.0 999.0 C 768 285 0 0 0 0 [[457, 716]] 1.0 6uan Homo sapiens TKL_BRAF_HUMAN TKL 1.3e-80 277.1 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6U2HC P15056 448 733 766.0 29L:60801 Type1 Inactive DFGin 6.75 14.236 BLAminus -140.81, -173.87 57.62, 73.3 -90.9, 27.8 291.38, 51.17 -64.94, -25.09 in-in in 8.624 Saltbr-in 2.732 HRD-in -81.66, -40.52 63.75, 1.44 in-in-out SNCiio in-out ActLoopNT-in 2.831 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -6.73 APE8-dihe-in -77.44, 81.11 APE8-rot-in 298.33 APE67-dihe-in -77.58, -10.43 -81.03, -23.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.369 None SEP729 SEP729 XRAY 2.5 0.222 0.263 C 290 275 11 0 0 11 [[457, 716]] 1.0 6u2h Homo sapiens TKL_BRAF_HUMAN TKL 5.2e-84 287.9 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6U2HD P15056 448 733 766.0 29L:60801 Type1 Inactive DFGin 6.362 13.853 BLAminus -135.68, 175.39 64.72, 81.19 -94.93, 22.46 283.79, 66.21 -67.34, -30.28 in-in in 8.599 Saltbr-in 2.78 HRD-in -78.94, -38.38 63.06, 1.76 in-in-out SNCiio in-out ActLoopNT-in 2.96 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 55.45, -147.38 APE9-dihe-na -70.68, -35.18 APE8-dihe-in -76.57, 92.11 APE8-rot-out 85.56 APE67-dihe-in -62.26, -37.46 -120.91, -2.65 APE12-dist-in 8.832 APE11-dist-in 9.503 APE10-dist-out 11.387 APE9-dist-out 11.583 None SEP729 SEP729 XRAY 2.5 0.222 0.263 D 290 283 3 0 0 3 [[457, 716]] 1.0 6u2h Homo sapiens TKL_BRAF_HUMAN TKL 5.2e-84 287.9 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4YHTA P15056 449 719 766.0 4EF:61002 Type1 Inactive DFGin 6.44 13.919 BLAminus -130.91, -175.71 59.89, 88.64 -101.88, 16.92 281.61, 73.69 -54.19, -26.07 in-in in 8.608 Saltbr-in 2.731 HRD-in -63.73, -42.35 62.62, 3.64 in-in-out SNCiio in-out ActLoopNT-in 2.881 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -6.83 APE8-dihe-in -100.18, 82.06 APE8-rot-in 287.27 APE67-dihe-in -63.55, -16.06 -74.16, -21.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.11 I543T,I544N,I551T,L706T,L716T None None XRAY 3.05 0.2 0.233 A 272 256 15 0 0 13 [[457, 716]] 1.0 4yht Homo sapiens TKL_BRAF_HUMAN TKL 2.7e-84 288.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4YHTB P15056 449 720 766.0 4EF:60802 Type1 Inactive DFGin 6.405 13.921 BLAminus -128.69, -172.56 54.11, 90.89 -102.92, 13.66 281.86, 71.12 -49.43, -28.96 in-in in 8.583 Saltbr-in 2.701 HRD-in -63.82, -42.99 62.91, 4.22 in-in-out SNCiio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -6.59 APE8-dihe-in -97.87, 80.96 APE8-rot-in 285.28 APE67-dihe-in -62.85, -18.47 -75.71, -20.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.034 I543T,I544N,I551T,L706T,L716T None None XRAY 3.05 0.2 0.233 B 272 258 14 0 0 12 [[457, 716]] 1.0 4yht Homo sapiens TKL_BRAF_HUMAN TKL 2.7e-84 288.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 2FB8A P15056 449 720 766.0 215:102 Type1 Inactive DFGin 6.49 14.247 BLAminus -146.27, -176.88 62.65, 94.56 -116.52, 20.29 274.9, 82.58 -45.53, -44.52 in-in in 8.885 Saltbr-in 2.919 HRD-in -63.2, -49.5 66.34, 11.44 in-in-out SNCiio in-out ActLoopNT-in 3.093 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 14.21 APE9-dihe-na 115.89, -169.69 APE8-dihe-in -101.37, 114.44 APE8-rot-in 279.54 APE67-dihe-in -65.73, -0.43 -52.43, -50.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.685 APE9-dist-in 5.958 None None None XRAY 2.9 0.203 0.291 A 281 259 13 0 0 13 [[457, 716]] 1.0 2fb8 Homo sapiens TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 2FB8B P15056 449 720 766.0 215:101 Type1 Inactive DFGin 6.479 14.148 BLAminus -111.07, -173.65 45.12, 91.89 -99.34, 30.47 289.04, 74.24 -44.77, -52.25 in-in in 8.669 Saltbr-in 3.215 HRD-in -70.79, -48.1 71.94, -5.57 in-in-out SNCiio in-out ActLoopNT-in 3.036 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnio APE10-dihe-na 999.0, 56.52 APE9-dihe-na 105.86, -135.38 APE8-dihe-in -106.43, 95.16 APE8-rot-in 246.18 APE67-dihe-in -77.85, -8.64 -35.19, -42.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.872 APE9-dist-out 6.834 None None None XRAY 2.9 0.203 0.291 B 281 259 13 0 0 13 [[457, 716]] 1.0 2fb8 Homo sapiens TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3D4QA P15056 448 723 766.0 SM5:1 Type1 Inactive DFGin 6.591 13.98 BLAminus -119.59, 176.85 67.73, 95.94 -114.03, 16.83 290.63, 70.02 -53.33, -35.88 in-in in 8.593 Saltbr-in 2.779 HRD-in -69.64, -42.7 65.9, 5.04 in-in-out SNCiio in-out ActLoopNT-in 2.91 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nooo APE10-dihe-na -176.28, 137.47 APE9-dihe-na -172.16, 131.15 APE8-dihe-out -92.13, -69.99 APE8-rot-in 247.02 APE67-dihe-out -57.22, -24.41 81.09, -39.44 APE12-dist-none 999.0 APE11-dist-out 15.289 APE10-dist-out 10.683 APE9-dist-out 9.333 None None None XRAY 2.8 0.216 0.25 A 307 264 12 0 0 12 [[457, 716]] 1.0 3d4q Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3D4QB P15056 448 723 766.0 SM5:1 Type1 Inactive DFGin 6.509 13.98 BLAminus -115.72, 179.48 64.55, 97.83 -118.24, 22.87 289.99, 73.94 -51.25, -41.28 in-in in 8.536 Saltbr-in 2.839 HRD-in -70.17, -40.87 65.01, 1.27 in-in-out SNCiio in-out ActLoopNT-in 2.897 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nooo APE10-dihe-na -176.8, 137.66 APE9-dihe-na -170.57, 133.86 APE8-dihe-out -95.43, -67.47 APE8-rot-in 248.38 APE67-dihe-out -55.71, -23.19 80.91, -41.16 APE12-dist-none 999.0 APE11-dist-out 15.289 APE10-dist-out 10.69 APE9-dist-out 9.387 None None None XRAY 2.8 0.216 0.25 B 307 264 12 0 0 12 [[457, 716]] 1.0 3d4q Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3PPKA P15056 448 723 766.0 FNI:727 Type1 Inactive DFGin 6.787 14.382 BLAminus -124.0, -178.09 61.54, 97.13 -118.14, 23.65 285.19, 77.52 -61.73, -35.13 in-in in 8.737 Saltbr-in 2.86 HRD-in -66.77, -41.36 66.1, 8.95 in-in-out SNCiio in-out ActLoopNT-in 2.934 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 99.28 APE8-dihe-in -100.64, 92.54 APE8-rot-out 47.4 APE67-dihe-in -51.11, -21.18 -88.3, -31.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.435 None None None XRAY 3.0 0.24 0.28 A 307 262 14 0 0 14 [[457, 716]] 1.0 3ppk Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3PPKB P15056 448 723 766.0 FNI:727 Type1 Inactive DFGin 6.709 14.378 BLAminus -125.5, 174.44 62.28, 98.6 -113.07, 20.9 286.12, 77.58 -56.3, -29.42 in-in in 8.315 Saltbr-in 2.694 HRD-in -66.38, -37.05 62.53, -7.49 in-in-out SNCiio in-out ActLoopNT-in 2.888 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -30.44, 114.56 APE9-dihe-na -161.69, -112.88 APE8-dihe-in -94.17, 136.57 APE8-rot-in 283.49 APE67-dihe-in -57.1, -15.24 -108.67, -33.54 APE12-dist-none 999.0 APE11-dist-in 8.399 APE10-dist-out 11.658 APE9-dist-out 8.314 None None None XRAY 3.0 0.24 0.28 B 307 264 12 0 0 12 [[457, 716]] 1.0 3ppk Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3PRIA P15056 448 723 766.0 FP4:727 Type1 Inactive DFGin 6.215 14.127 BLAminus -135.2, 167.28 72.88, 95.66 -113.67, 26.28 291.49, 68.16 -64.26, -12.29 in-in in 7.819 Saltbr-in 3.236 HRD-in -75.89, -45.29 67.83, 4.74 in-in-out SNCiio in-out ActLoopNT-in 2.919 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na 176.55, 160.69 APE9-dihe-na -174.14, 132.32 APE8-dihe-in -103.13, 129.4 APE8-rot-in 329.91 APE67-dihe-in -52.17, -13.03 -124.84, -28.03 APE12-dist-none 999.0 APE11-dist-out 15.441 APE10-dist-out 11.72 APE9-dist-out 9.456 None None None XRAY 3.5 0.245 0.303 A 307 264 12 0 0 12 [[457, 716]] 1.0 3pri Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3PRIB P15056 448 723 766.0 FP4:727 Type1 Inactive DFGin 6.276 14.119 BLAminus -135.51, 166.8 73.87, 93.46 -111.51, 27.64 290.87, 67.31 -64.08, -14.39 in-in in 7.843 Saltbr-in 3.198 HRD-in -77.37, -41.63 65.39, 3.71 in-in-out SNCiio in-out ActLoopNT-in 2.926 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na 175.7, 161.19 APE9-dihe-na -175.35, 132.33 APE8-dihe-in -100.79, 127.95 APE8-rot-in 333.36 APE67-dihe-in -51.21, -11.34 -122.71, -29.84 APE12-dist-none 999.0 APE11-dist-out 15.444 APE10-dist-out 11.699 APE9-dist-out 9.43 None None None XRAY 3.5 0.245 0.303 B 307 264 12 0 0 12 [[457, 716]] 1.0 3pri Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3PSBA P15056 448 723 766.0 SM6:1 Type1 Inactive DFGin 6.662 14.269 BLAminus -125.3, 175.18 70.16, 91.03 -111.9, 31.45 288.37, 77.4 -63.51, -33.07 in-in in 8.905 Saltbr-in 2.816 HRD-in -79.27, -40.84 66.72, 0.33 in-in-out SNCiio in-out ActLoopNT-in 2.863 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -36.93 APE8-dihe-in -106.54, 109.48 APE8-rot-out 47.62 APE67-dihe-in -64.21, -24.1 -90.91, -19.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.548 None None None XRAY 3.4 0.227 0.268 A 307 262 14 0 0 14 [[457, 716]] 1.0 3psb Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3PSBB P15056 448 723 766.0 SM6:2 Type1 Inactive DFGin 6.454 14.334 BLAminus -122.43, 177.07 60.31, 95.43 -106.26, 23.21 282.6, 72.21 -49.54, -41.79 in-in in 8.963 Saltbr-in 2.886 HRD-in -72.06, -46.11 69.91, 7.1 in-in-out SNCiio in-out ActLoopNT-in 2.884 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -97.04, -173.46 APE9-dihe-na 154.34, -136.18 APE8-dihe-in -110.25, 135.65 APE8-rot-out 42.37 APE67-dihe-in -65.97, -15.91 -96.73, -17.75 APE12-dist-none 999.0 APE11-dist-in 8.301 APE10-dist-out 10.37 APE9-dist-out 7.559 None None None XRAY 3.4 0.227 0.268 B 307 264 12 0 0 12 [[457, 716]] 1.0 3psb Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3PSDA P15056 448 723 766.0 SM7:1 Type1 Inactive DFGin 6.833 14.15 BLAminus -124.82, -173.12 58.04, 92.45 -113.75, 29.97 285.75, 86.06 -69.4, -23.14 in-in in 8.529 Saltbr-in 2.855 HRD-in -68.2, -46.27 67.99, 0.3 in-in-out SNCiio in-out ActLoopNT-in 3.073 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -64.61 APE8-dihe-in -100.67, 127.64 APE8-rot-out 52.84 APE67-dihe-in -68.31, -19.86 -96.93, -21.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.421 None None None XRAY 3.6 0.28 0.335 A 307 262 14 0 0 14 [[457, 716]] 1.0 3psd Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3PSDB P15056 448 723 766.0 SM7:2 Type1 Inactive DFGin 6.685 14.142 BLAminus -119.75, -174.7 61.11, 89.79 -111.04, 26.35 285.59, 87.99 -65.63, -24.51 in-in in 8.658 Saltbr-in 2.813 HRD-in -69.49, -46.17 68.55, -0.6 in-in-out SNCiio in-out ActLoopNT-in 3.078 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -70.44, 155.68 APE9-dihe-na 171.41, -116.26 APE8-dihe-in -82.49, 133.65 APE8-rot-out 55.09 APE67-dihe-in -67.11, -16.33 -104.44, -22.29 APE12-dist-none 999.0 APE11-dist-in 8.049 APE10-dist-out 11.69 APE9-dist-out 8.401 None None None XRAY 3.6 0.28 0.335 B 307 264 12 0 0 12 [[457, 716]] 1.0 3psd Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3Q4CA P15056 448 723 766.0 RSW:60001 Type1 Inactive DFGin 6.444 14.235 BLAminus -146.59, -170.54 63.5, 77.08 -100.12, 34.36 288.59, 75.88 -64.75, -40.97 in-in in 8.552 Saltbr-in 3.431 HRD-in -69.37, -57.8 78.74, 3.85 in-in-out SNCiio in-out ActLoopNT-in 3.139 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 83.59 APE9-dihe-na -85.67, 50.75 APE8-dihe-in -115.48, 63.75 APE8-rot-out 49.22 APE67-dihe-in -67.89, -18.46 -76.77, -7.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.574 APE9-dist-out 10.668 None None None XRAY 3.2 0.232 0.28 A 307 264 12 0 0 12 [[457, 716]] 1.0 3q4c Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4E26A P15056 448 723 766.0 734:801 Type1 Inactive DFGin 6.548 14.259 BLAminus -123.09, -155.83 45.29, 82.31 -99.48, 28.47 287.12, 71.36 -65.78, -23.11 in-in in 8.473 Saltbr-in 3.276 HRD-in -66.92, -52.0 73.01, 1.38 in-in-out SNCiio in-out ActLoopNT-in 2.882 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na 176.82, 70.9 APE9-dihe-na -151.07, -48.08 APE8-dihe-in -102.0, 76.55 APE8-rot-out 48.66 APE67-dihe-in -58.71, -28.19 -81.89, -17.55 APE12-dist-out 6.526 APE11-dist-out 6.954 APE10-dist-out 12.284 APE9-dist-out 10.192 None None None XRAY 2.55 0.22 0.262 A 307 270 6 0 0 6 [[457, 716]] 1.0 4e26 Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7SHVA P15056 449 721 766.0 29L:60801 Type1 Inactive DFGin 7.149 13.975 BLAminus -147.63, -169.13 58.79, 78.75 -106.95, 34.37 285.73, 83.49 -85.44, -39.06 in-in in 8.58 Saltbr-in 2.607 HRD-in -66.2, -50.26 77.35, -0.9 in-in-out SNCiio in-out ActLoopNT-in 2.912 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnio APE10-dihe-na 999.0, -52.91 APE9-dihe-na 60.55, -7.98 APE8-dihe-in -83.24, 65.36 APE8-rot-out 38.35 APE67-dihe-in -63.32, -24.58 -66.92, -44.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.959 APE9-dist-out 9.497 None None None XRAY 2.88 0.221 0.242 A 308 261 12 0 0 12 [[457, 716]] 1.0 7shv Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4MNFB P15056 449 720 766.0 29L:801 Type1 Inactive DFGin 6.486 13.922 BLAminus -122.68, -176.93 63.73, 92.47 -110.65, 27.31 288.5, 68.83 -50.42, -45.23 in-in in 8.699 Saltbr-in 2.866 HRD-in -76.32, -52.93 74.07, 3.14 in-in-out SNCiio in-out ActLoopNT-in 3.063 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 13.12 APE8-rot-out 79.33 APE67-dihe-in -65.4, -15.67 -79.06, -24.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 V600E None None XRAY 2.802 0.215 0.275 B 329 257 15 0 0 15 [[457, 716]] 1.0 4mnf Homo sapiens TKL_BRAF_HUMAN TKL 1.4e-81 279.9 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7MFFA P15056 449 732 766.0 215:801 Type1 Inactive DFGin 6.36 14.742 BLAminus -112.03, -166.91 58.58, 66.73 -90.64, 30.13 276.88, 45.65 -62.65, -42.41 in-out in 9.03 Saltbr-out 4.521 HRD-in -80.55, -46.77 72.64, -3.52 out-in-out SNCoio in-out ActLoopNT-in 3.118 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -12.78 APE9-dihe-na 72.05, -150.48 APE8-dihe-in -69.83, 149.19 APE8-rot-out 174.32 APE67-dihe-in -65.5, -22.12 -103.63, -2.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.005 APE9-dist-out 9.013 None SEP365,SEP729 SEP365,SEP729 EM 3.89 999.0 999.0 A 766 271 13 0 0 13 [[457, 716]] 1.0 7mff Homo sapiens TKL_BRAF_HUMAN TKL 1.3e-80 277.1 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7MFFB P15056 449 733 766.0 215:801 Type1 Inactive DFGin 6.597 15.01 BLAminus -114.09, -161.38 57.73, 64.61 -99.79, 23.65 275.25, 74.28 -77.75, -48.0 in-in in 9.896 Saltbr-in 3.331 HRD-in -85.83, -46.32 64.25, 3.39 in-in-out SNCiio in-out ActLoopNT-in 3.041 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, -42.1 APE9-dihe-na 151.05, -167.76 APE8-dihe-in -113.77, 134.96 APE8-rot-out 186.35 APE67-dihe-in -104.87, -21.77 -63.7, -3.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.552 APE9-dist-in 5.872 None SEP365,SEP729 SEP365,SEP729 EM 3.89 999.0 999.0 B 766 272 13 0 0 13 [[457, 716]] 1.0 7mff Homo sapiens TKL_BRAF_HUMAN TKL 1.3e-80 277.1 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3PPJA P15056 448 723 766.0 FOI:727 Type1.5_Back Inactive DFGin 6.512 14.144 BLAminus -118.68, 162.14 70.52, 93.12 -108.75, 36.02 292.03, 61.87 -65.84, -21.38 in-in in 8.592 Saltbr-in 2.735 HRD-in -81.51, -38.2 60.89, 6.44 in-in-out SNCiio in-out ActLoopNT-in 2.903 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -75.6 APE8-dihe-in -107.01, 122.44 APE8-rot-in 355.7 APE67-dihe-in -62.87, -11.96 -106.79, -22.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.701 None None None XRAY 3.7 0.251 0.272 A 307 262 14 0 0 14 [[457, 716]] 1.0 3ppj Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3PPJB P15056 448 723 766.0 FOI:727 Type1.5_Back Inactive DFGin 6.498 14.158 BLAminus -117.7, 161.15 71.69, 92.42 -107.49, 34.88 292.55, 61.48 -64.16, -21.41 in-in in 8.599 Saltbr-in 2.762 HRD-in -81.58, -39.05 61.66, 5.65 in-in-out SNCiio in-out ActLoopNT-in 2.899 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -45.39, 125.84 APE9-dihe-na -167.47, -85.86 APE8-dihe-in -107.52, 124.34 APE8-rot-in 353.86 APE67-dihe-in -62.54, -12.0 -107.16, -21.64 APE12-dist-none 999.0 APE11-dist-in 8.478 APE10-dist-out 11.708 APE9-dist-out 8.628 None None None XRAY 3.7 0.251 0.272 B 307 264 12 0 0 12 [[457, 716]] 1.0 3ppj Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7SHVB P15056 449 721 766.0 29L:60801 Type1.5_Back Inactive DFGin 6.736 14.171 BLAminus -147.31, -168.46 59.95, 68.87 -90.82, 20.67 284.09, 50.14 -57.74, -56.04 in-in in 8.771 Saltbr-in 2.802 HRD-in -76.59, -37.99 67.86, -2.2 in-in-out SNCiio in-out ActLoopNT-in 2.859 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnio APE10-dihe-na 999.0, -136.62 APE9-dihe-na -141.24, 15.82 APE8-dihe-in -103.28, 75.96 APE8-rot-in 280.52 APE67-dihe-in -56.94, -26.52 -73.16, -41.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.391 APE9-dist-out 9.402 None None None XRAY 2.88 0.221 0.242 B 308 262 11 0 0 11 [[457, 716]] 1.0 7shv Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5JSMA P15056 448 721 766.0 No_ligand No_ligand Inactive DFGin 6.391 13.039 BLAplus -138.4, -174.44 69.43, 19.37 -96.67, -11.2 60.48, 90.73 -70.16, 170.4 out-out out 12.519 Saltbr-out 11.848 HRD-in -67.42, -52.76 81.37, -8.85 out-out-out SNCooo out-out ActLoopNT-out 7.37 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -126.49 APE9-dihe-na -72.61, -3.43 APE8-dihe-out -78.38, -5.15 APE8-rot-in 323.72 APE67-dihe-in -63.19, -24.3 -66.02, -22.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.021 APE9-dist-out 11.751 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.19 0.209 0.26 A 280 262 12 0 0 12 [[457, 716]] 1.0 5jsm Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5JSMD P15056 448 721 766.0 No_ligand No_ligand Inactive DFGin 6.123 13.031 BLAplus -131.14, -174.1 61.1, 20.52 -90.6, -7.92 60.52, 88.06 -77.98, 170.41 out-out out 12.232 Saltbr-out 11.469 HRD-in -70.97, -49.77 79.36, -15.05 out-out-out SNCooo out-out ActLoopNT-out 6.931 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -122.39 APE9-dihe-na -69.86, -160.53 APE8-dihe-out 66.03, 26.93 APE8-rot-out 79.84 APE67-dihe-in -63.53, -17.75 -74.4, -20.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.286 APE9-dist-out 11.499 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.19 0.209 0.26 D 280 255 19 0 0 11 [[457, 716]] 1.0 5jsm Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5JT2B P15056 448 719 766.0 No_ligand No_ligand Inactive DFGin 6.475 13.127 BLAplus -132.05, -178.42 60.44, 26.71 -91.43, -16.34 56.91, 94.97 -75.01, 161.8 out-out out 12.667 Saltbr-out 10.981 HRD-in -71.51, -55.74 82.51, -8.57 out-out-out SNCooo out-out ActLoopNT-out 7.395 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -9.45 APE8-rot-out 58.42 APE67-dihe-in -62.61, -14.07 -74.77, -25.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.702 0.216 0.273 B 280 250 22 0 0 16 [[457, 716]] 1.0 5jt2 Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5JT2D P15056 448 718 766.0 No_ligand No_ligand Inactive DFGin 6.579 13.39 BLAplus -136.04, -175.12 61.39, 23.06 -96.39, -13.73 60.15, 86.19 -72.12, 160.9 out-out out 12.512 Saltbr-out 11.095 HRD-in -68.92, -57.27 83.18, -10.11 out-out-out SNCooo out-out ActLoopNT-out 7.019 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -2.9 APE8-rot-out 210.05 APE67-dihe-in -67.61, -13.98 -75.83, -31.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.702 0.216 0.273 D 280 232 39 0 0 15 [[457, 716]] 1.0 5jt2 Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6UANB P15056 449 750 766.0 No_ligand No_ligand Inactive DFGin 6.087 12.636 BLAplus -154.71, 179.74 58.46, 43.55 -98.79, 69.87 37.99, 91.03 -71.09, -56.22 in-out in 9.594 Saltbr-out 7.483 HRD-in -73.07, -51.77 71.88, -8.56 out-in-none SNCoin in-none ActLoopNT-in 3.233 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T373C,I374M SEP729 SEP729 EM 3.9 999.0 999.0 B 768 261 41 0 0 21 [[457, 716]] 1.0 6uan Homo sapiens TKL_BRAF_HUMAN TKL 1.3e-80 277.1 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 9BFBA P15056 448 721 766.0 A1AN9:803 Type1 Inactive DFGin 5.324 13.571 BLAplus -126.78, -169.92 68.06, 26.72 -98.4, -4.13 57.41, 91.95 -79.05, 165.15 out-out out 12.668 Saltbr-out 12.074 HRD-in -66.55, -53.43 79.05, -12.09 out-out-out SNCooo out-out ActLoopNT-out 8.862 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -57.65, -38.69 APE9-dihe-na -78.55, -14.23 APE8-dihe-out -117.57, -4.84 APE8-rot-out 65.23 APE67-dihe-in -63.24, -28.07 -55.27, -36.67 APE12-dist-in 12.058 APE11-dist-out 16.695 APE10-dist-out 19.29 APE9-dist-out 10.837 F667A,R671A,Y673A None None XRAY 1.92 0.166 0.189 A 294 272 2 0 0 0 [[457, 716]] 1.0 9bfb Homo sapiens TKL_BRAF_HUMAN TKL 1e-81 280.4 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 9BP8A P15056 449 721 766.0 A1AQY:801 Type1 Inactive DFGin 5.22 13.557 BLAplus -129.41, -173.26 66.62, 35.11 -102.57, -8.15 57.04, 89.1 -72.95, 156.71 out-out out 13.126 Saltbr-out 11.44 HRD-in -67.37, -53.21 82.55, -13.02 out-out-out SNCooo out-out ActLoopNT-out 9.031 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -60.62, -35.92 APE9-dihe-na -79.61, -15.25 APE8-dihe-out -112.44, -12.93 APE8-rot-in 291.55 APE67-dihe-in -61.23, -28.38 -53.66, -40.13 APE12-dist-in 11.885 APE11-dist-out 16.59 APE10-dist-out 19.005 APE9-dist-out 10.527 F667A,R671A,Y673A None None XRAY 1.73 0.166 0.193 A 294 273 0 0 0 0 [[457, 716]] 1.0 9bp8 Homo sapiens TKL_BRAF_HUMAN TKL 1e-81 280.4 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5FD2B P15056 449 720 766.0 5XJ:801 Type1 Inactive DFGin 6.515 12.754 BLAplus -160.33, 172.82 88.44, 33.77 -112.02, 12.86 60.15, 87.86 -69.02, 999.0 out-none out 11.96 Saltbr-none 999.0 HRD-in -57.39, -37.56 64.99, -12.71 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 171.99 APE9-dihe-na -126.99, 19.84 APE8-dihe-in -138.9, 57.46 APE8-rot-in 290.89 APE67-dihe-in -57.69, -25.53 -71.85, -27.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.999 None None None XRAY 2.89 0.216 0.278 B 300 234 38 0 0 17 [[457, 716]] 1.0 5fd2 Homo sapiens TKL_BRAF_HUMAN TKL 1e-81 280.4 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3SKCB P15056 448 723 766.0 BR2:801 Type1 Inactive DFGin 5.463 14.203 BLAplus -135.93, 171.09 86.44, 39.5 -114.85, -0.83 58.51, 73.54 -75.68, 174.8 out-out out 11.35 Saltbr-out 11.059 HRD-in -71.95, -50.11 76.71, 2.16 out-out-out SNCooo out-out ActLoopNT-out 8.683 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -168.63, -26.01 APE9-dihe-na -100.89, 7.04 APE8-dihe-out -156.0, 39.42 APE8-rot-out 37.87 APE67-dihe-in -67.54, -21.27 -78.88, -19.35 APE12-dist-in 11.09 APE11-dist-out 14.619 APE10-dist-out 17.407 APE9-dist-out 10.328 None None None XRAY 3.2 0.235 0.271 B 307 276 0 0 0 0 [[457, 716]] 1.0 3skc Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 8VYUA P15056 235 738 766.0 A1AEN:801 Type1 Inactive DFGin 7.167 13.275 BLAplus -117.18, -150.85 59.81, 31.27 -110.17, 13.73 54.05, 90.61 -85.24, -171.83 out-out out 13.497 Saltbr-out 10.409 HRD-out -111.09, 143.69 -109.47, -35.63 out-out-none SNCoon out-none ActLoopNT-out 10.157 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP365,SEP729 SEP365,SEP729 EM 4.07 999.0 999.0 A 767 290 58 0 0 22 [[457, 716]] 1.0 8vyu Homo sapiens TKL_BRAF_HUMAN TKL 2.8e-81 279.2 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4CQEA P15056 449 720 766.0 CQE:1721 Type1.5_Back Inactive DFGin 5.478 13.664 BLAplus -125.88, -177.56 65.78, 47.02 -122.69, 7.58 61.31, 87.06 -91.72, 999.0 out-out out 10.982 Saltbr-out 5.484 HRD-in -68.23, -53.22 84.59, -16.79 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -19.36 APE8-dihe-out -111.66, 7.78 APE8-rot-in 306.87 APE67-dihe-in -63.32, -25.17 -66.28, -32.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.467 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.3 0.21 0.255 A 278 250 22 0 0 18 [[457, 716]] 1.0 4cqe Homo sapiens TKL_BRAF_HUMAN TKL 4.5e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5JRQA P15056 448 719 766.0 6N9:60801 Type1.5_Back Inactive DFGin 6.383 12.701 BLAplus -128.11, -173.12 63.43, 15.29 -89.17, -1.57 61.53, 90.6 -61.67, 159.33 out-out out 12.012 Saltbr-out 11.509 HRD-in -71.32, -62.23 83.15, -16.2 out-out-none SNCoon out-none ActLoopNT-out 6.585 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -5.1 APE8-rot-in 271.28 APE67-dihe-in -63.55, -24.37 -59.37, -34.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.287 0.2 0.254 A 280 257 15 0 0 12 [[457, 716]] 1.0 5jrq Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5JRQB P15056 448 720 766.0 6N9:60801 Type1.5_Back Inactive DFGin 6.17 12.698 BLAplus -133.12, -173.75 67.64, 13.36 -87.31, -1.91 62.04, 89.76 -64.01, 169.14 out-out out 12.002 Saltbr-out 11.845 HRD-in -80.28, -50.19 74.7, -17.58 out-out-none SNCoon out-none ActLoopNT-out 6.658 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -66.56, -23.24 999.0, -42.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.287 0.2 0.254 B 280 245 28 0 0 16 [[457, 716]] 1.0 5jrq Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5JSMB P15056 448 721 766.0 6NB:60801 Type1.5_Back Inactive DFGin 6.062 13.115 BLAplus -131.27, -176.98 63.39, 23.33 -93.63, -10.63 60.2, 91.2 -76.07, 171.28 out-out out 12.226 Saltbr-out 11.076 HRD-in -71.71, -49.86 78.57, -16.34 out-out-none SNCoon out-none ActLoopNT-out 6.866 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 9.89 APE8-rot-in 315.15 APE67-dihe-in -61.71, -26.31 -77.16, -23.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.19 0.209 0.26 B 280 259 15 0 0 12 [[457, 716]] 1.0 5jsm Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5JSMC P15056 448 722 766.0 6NB:60801 Type1.5_Back Inactive DFGin 6.383 13.11 BLAplus -129.7, -173.18 63.38, 21.31 -96.67, -12.5 57.76, 93.77 -77.13, 167.54 out-out out 12.637 Saltbr-out 11.85 HRD-in -70.95, -49.33 78.01, -16.99 out-out-out SNCooo out-out ActLoopNT-out 6.854 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 9.67 APE8-rot-out 63.05 APE67-dihe-in -58.68, -22.16 -80.83, -26.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.19 0.209 0.26 C 280 259 16 0 0 15 [[457, 716]] 1.0 5jsm Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5JT2A P15056 448 719 766.0 6NC:60802 Type1.5_Back Inactive DFGin 6.222 12.912 BLAplus -131.83, -179.76 60.44, 27.47 -91.8, -15.26 60.84, 91.27 -76.03, 163.63 out-out out 12.161 Saltbr-out 10.863 HRD-in -68.55, -55.07 79.46, -6.74 out-out-out SNCooo out-out ActLoopNT-out 6.973 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -10.99 APE8-rot-out 59.11 APE67-dihe-in -63.98, -11.05 -84.27, -24.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.702 0.216 0.273 A 280 253 19 0 0 11 [[457, 716]] 1.0 5jt2 Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5JT2C P15056 448 719 766.0 6NC:60801 Type1.5_Back Inactive DFGin 6.266 13.213 BLAplus -132.63, 179.4 60.59, 25.36 -92.03, -16.73 59.91, 87.97 -73.39, 163.09 out-out out 12.305 Saltbr-out 11.076 HRD-in -70.05, -56.98 80.65, -10.11 out-out-out SNCooo out-out ActLoopNT-out 6.95 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -13.76 APE8-rot-out 58.86 APE67-dihe-in -62.78, -11.84 -84.22, -24.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.702 0.216 0.273 C 280 247 25 0 0 12 [[457, 716]] 1.0 5jt2 Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4RZVA P15056 449 721 766.0 032:801 Type1.5_Back Inactive DFGin 6.623 12.87 BLAplus -130.91, -172.9 60.6, 24.8 -98.53, -10.69 57.76, 91.05 -69.22, 172.66 out-out out 12.644 Saltbr-out 10.258 HRD-in -67.58, -51.33 73.51, -5.96 out-out-out SNCooo out-out ActLoopNT-out 7.109 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -135.17, 121.31 APE9-dihe-na -132.69, 47.25 APE8-dihe-in -116.19, 105.13 APE8-rot-in 306.78 APE67-dihe-in -65.92, -31.75 -100.96, -1.47 APE12-dist-none 999.0 APE11-dist-in 13.566 APE10-dist-out 15.169 APE9-dist-out 10.302 R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.994 0.207 0.267 A 281 261 12 0 0 12 [[457, 716]] 1.0 4rzv Homo sapiens TKL_BRAF_HUMAN TKL 7.2e-84 287.4 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4RZVB P15056 449 722 766.0 032:801 Type1.5_Back Inactive DFGin 6.47 12.835 BLAplus -121.2, 178.65 56.71, 36.71 -99.28, -19.01 59.27, 87.57 -68.87, 172.54 out-out out 12.328 Saltbr-out 11.67 HRD-in -71.84, -50.61 63.03, 10.44 out-out-out SNCooo out-out ActLoopNT-out 6.743 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -82.65, 28.28 APE9-dihe-na -100.48, -28.28 APE8-dihe-in -136.49, 95.01 APE8-rot-in 296.61 APE67-dihe-in -55.46, -18.41 -85.27, -21.3 APE12-dist-in 13.178 APE11-dist-in 13.816 APE10-dist-out 18.847 APE9-dist-out 11.166 R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.994 0.207 0.267 B 281 271 3 0 0 0 [[457, 716]] 1.0 4rzv Homo sapiens TKL_BRAF_HUMAN TKL 7.2e-84 287.4 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4XV1A P15056 449 705 766.0 904:60801 Type1.5_Back Inactive DFGin 5.265 13.518 BLAplus -126.0, -170.09 68.06, 24.34 -98.7, -10.99 52.38, 90.09 -65.7, 999.0 out-out out 11.078 Saltbr-out 8.082 HRD-in -65.2, -48.41 74.87, -5.74 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, -52.0 APE9-dihe-na -137.15, 170.54 APE8-dihe-in -90.29, 107.37 APE8-rot-out 51.85 APE67-dihe-in -59.87, -29.31 -94.54, -12.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.673 S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R None None XRAY 2.47 0.236 0.273 A 292 228 29 0 0 17 [[457, 716]] 1.0 4xv1 Homo sapiens TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4XV3A P15056 448 705 766.0 P02:60801 Type1.5_Back Inactive DFGin 5.531 13.402 BLAplus -134.46, -171.77 61.26, 48.36 -114.54, -11.83 46.72, 87.81 -64.98, 999.0 out-out out 11.101 Saltbr-out 10.159 HRD-in -61.64, -42.75 69.87, -4.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 19.55 APE9-dihe-na -138.7, -116.01 APE8-dihe-in -79.73, 110.93 APE8-rot-out 50.96 APE67-dihe-in -61.23, -22.36 -102.85, -13.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.336 S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R None None XRAY 2.8 0.26 0.296 A 292 232 26 0 0 17 [[457, 716]] 1.0 4xv3 Homo sapiens TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4FK3A P15056 448 718 766.0 325:801 Type1.5_Back Inactive DFGin 5.366 13.695 BLAplus -133.88, -167.56 58.89, 45.8 -124.05, 12.28 65.31, 91.87 -122.04, 999.0 out-out out 11.004 Saltbr-out 9.73 HRD-in -61.94, -44.69 76.48, -14.73 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 26.64 APE9-dihe-na -141.77, -157.8 APE8-dihe-in -80.67, 92.47 APE8-rot-in 332.2 APE67-dihe-in -66.02, -29.09 -81.79, -14.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.34 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.65 0.262 0.315 A 292 251 20 0 0 17 [[457, 716]] 1.0 4fk3 Homo sapiens TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6UUOB P15056 448 721 766.0 QH1:801 Type1.5_Back Inactive DFGin 5.804 13.272 BLAplus -152.6, -159.47 58.51, 46.15 -126.1, 28.18 55.52, 85.25 -102.19, 999.0 out-out out 11.675 Saltbr-out 8.592 HRD-out -75.28, 102.15 -78.85, -32.66 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 145.23 APE8-dihe-out -88.62, 38.26 APE8-rot-out 65.25 APE67-dihe-in -65.54, -37.74 -66.97, -36.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 22.994 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.288 0.265 0.288 B 284 252 22 0 0 18 [[457, 716]] 1.0 6uuo Homo sapiens TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5ITAA P15056 448 718 766.0 6DC:801 Type1.5_Back Inactive DFGin 5.055 13.46 BLAplus -120.12, -172.98 68.68, 46.04 -122.35, 5.81 57.91, 88.28 -59.19, -177.17 out-out out 10.684 Saltbr-out 5.233 HRD-in -60.95, -54.03 78.17, -8.74 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -164.16 APE8-rot-in 278.34 APE67-dihe-in -68.96, -22.68 -78.66, -20.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 1.95 0.197 0.244 A 297 250 21 0 0 18 [[457, 716]] 1.0 5ita Homo sapiens TKL_BRAF_HUMAN TKL 5.7e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4WO5A P15056 448 721 766.0 324:801 Type1.5_Back Inactive DFGin 6.197 12.471 BLAplus -113.39, 171.89 60.4, 25.87 -88.62, -20.81 62.14, 83.22 -76.85, 162.27 out-out out 11.855 Saltbr-out 10.947 HRD-in -61.99, -45.91 75.82, -24.69 out-out-out SNCooo out-out ActLoopNT-out 6.802 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iooo APE10-dihe-na -106.86, 132.67 APE9-dihe-na -94.97, 98.91 APE8-dihe-out -154.69, -103.68 APE8-rot-out 172.98 APE67-dihe-out -59.88, -33.44 59.76, -29.06 APE12-dist-in 13.661 APE11-dist-out 17.614 APE10-dist-out 20.645 APE9-dist-out 12.338 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.83 0.196 0.26 A 300 266 8 0 0 4 [[457, 716]] 1.0 4wo5 Homo sapiens TKL_BRAF_HUMAN TKL 5.9e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4WO5B P15056 450 721 766.0 324:801 Type1.5_Back Inactive DFGin 6.888 12.867 BLAplus -140.91, 168.85 84.0, 47.56 -114.71, 82.32 38.72, 99.17 -44.17, -77.3 out-none out 11.966 Saltbr-none 999.0 HRD-in -57.15, -60.67 87.46, -19.9 none-out-out SNCnoo out-out ActLoopNT-out 9.245 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -63.37 APE8-dihe-in -130.43, 79.93 APE8-rot-in 273.2 APE67-dihe-in -55.15, -30.0 -52.46, -34.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.189 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.83 0.196 0.26 B 300 257 15 0 0 15 [[457, 716]] 1.0 4wo5 Homo sapiens TKL_BRAF_HUMAN TKL 5.9e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3OG7A P15056 449 720 766.0 032:1 Type1.5_Back Inactive DFGin 5.36 13.446 BLAplus -137.59, -179.01 76.97, 18.21 -89.25, -11.03 54.09, 93.51 -42.45, 999.0 out-out out 11.242 Saltbr-out 8.406 HRD-in -57.13, -46.63 78.91, -15.01 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -115.54 APE8-dihe-in -81.75, 114.02 APE8-rot-out 53.56 APE67-dihe-in -69.21, -23.46 -108.29, -5.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.262 K522A,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 2.45 0.214 0.258 A 289 247 25 0 0 18 [[457, 716]] 1.0 3og7 Homo sapiens TKL_BRAF_HUMAN TKL 1.2e-83 286.6 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4EHGA P15056 448 723 766.0 RI9:801 Type1.5_Back Inactive DFGin 5.855 13.82 BLAplus -113.94, 175.52 73.83, 70.69 -143.13, -9.0 47.54, 75.61 -62.53, 153.47 out-out out 11.628 Saltbr-out 10.57 HRD-in -82.57, -33.1 63.93, -24.44 out-out-out SNCooo out-out ActLoopNT-out 7.414 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -27.9 APE8-dihe-in -157.45, 120.42 APE8-rot-out 42.51 APE67-dihe-in -59.0, -29.49 -117.63, -12.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.335 V600E None None XRAY 3.5 0.215 0.27 A 307 262 14 0 0 14 [[457, 716]] 1.0 4ehg Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.2 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4EHGB P15056 448 723 766.0 RI9:801 Type1.5_Back Inactive DFGin 5.267 13.707 BLAplus -134.99, -176.48 67.9, 27.36 -89.31, -32.37 52.05, 105.83 -56.04, 153.23 out-out out 11.602 Saltbr-out 10.458 HRD-in -79.82, -38.1 68.62, -6.56 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -131.11 APE9-dihe-na -82.46, 60.2 APE8-dihe-in -164.62, 72.39 APE8-rot-out 68.9 APE67-dihe-in -59.85, -21.12 -109.92, -9.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.596 APE9-dist-out 11.826 V600E None None XRAY 3.5 0.215 0.27 B 307 260 16 0 0 16 [[457, 716]] 1.0 4ehg Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.2 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5FD2A P15056 448 720 766.0 5XJ:801 Type1.5_Back Inactive DFGin 5.671 13.483 BLAplus -131.37, -172.89 52.29, 39.93 -105.53, -8.5 56.1, 88.04 -63.55, 167.18 out-out out 12.509 Saltbr-out 10.07 HRD-in -66.35, -44.8 69.83, -6.15 out-out-out SNCooo out-out ActLoopNT-out 7.746 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -37.28 APE9-dihe-na -133.55, 43.79 APE8-dihe-out -129.77, 15.23 APE8-rot-in 311.9 APE67-dihe-in -66.32, -26.35 -70.67, -25.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.448 APE9-dist-out 10.545 None None None XRAY 2.89 0.216 0.278 A 300 264 9 0 0 9 [[457, 716]] 1.0 5fd2 Homo sapiens TKL_BRAF_HUMAN TKL 1e-81 280.4 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3TV4A P15056 448 723 766.0 TV4:1 Type1.5_Back Inactive DFGin 5.402 13.697 BLAplus -142.83, -171.49 46.74, 47.2 -119.19, -6.43 69.26, 117.52 -75.58, 165.81 out-out out 12.033 Saltbr-out 11.313 HRD-in -68.61, -47.44 76.91, -23.27 out-out-out SNCooo out-out ActLoopNT-out 9.064 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -82.49 APE9-dihe-na -79.94, 51.24 APE8-dihe-out -152.88, 1.97 APE8-rot-in 289.52 APE67-dihe-in -59.4, -38.95 -39.48, -42.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.881 APE9-dist-out 10.479 None None None XRAY 3.4 0.244 0.307 A 307 264 12 0 0 10 [[457, 716]] 1.0 3tv4 Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3TV4B P15056 448 723 766.0 TV4:1 Type1.5_Back Inactive DFGin 5.453 13.695 BLAplus -121.56, -159.18 14.55, 74.26 -129.62, -2.38 64.64, 122.32 -64.07, -82.37 out-out out 11.627 Saltbr-out 10.593 HRD-in -79.62, -54.84 87.21, -27.02 out-out-out SNCooo out-out ActLoopNT-out 8.571 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -77.3, -34.85 APE9-dihe-na -85.7, 48.56 APE8-dihe-out -160.1, -10.48 APE8-rot-in 291.93 APE67-dihe-in -59.37, -49.79 -52.97, -39.23 APE12-dist-in 10.775 APE11-dist-out 14.274 APE10-dist-out 17.99 APE9-dist-out 10.256 None None None XRAY 3.4 0.244 0.307 B 307 276 0 0 0 0 [[457, 716]] 1.0 3tv4 Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3TV6A P15056 448 723 766.0 B0R:1 Type1.5_Back Inactive DFGin 5.276 13.377 BLAplus -121.97, -177.73 69.22, 15.6 -85.44, -8.43 61.04, 102.69 -77.52, 161.68 out-out out 11.947 Saltbr-out 10.65 HRD-out -67.75, -47.34 58.38, 69.46 out-out-out SNCooo out-out ActLoopNT-out 8.407 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 132.99 APE9-dihe-na 61.12, -175.64 APE8-dihe-out 54.5, 0.69 APE8-rot-in 303.6 APE67-dihe-in -61.66, -28.98 -65.54, -27.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.017 APE9-dist-out 11.525 None None None XRAY 3.3 0.24 0.288 A 307 268 8 0 0 8 [[457, 716]] 1.0 3tv6 Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3TV6B P15056 448 723 766.0 B0R:1 Type1.5_Back Inactive DFGin 5.502 13.843 BLAplus -125.08, -169.86 55.0, 38.89 -104.29, -19.25 56.18, 93.9 -40.71, -81.07 out-out out 11.869 Saltbr-out 10.492 HRD-in -64.31, -49.25 75.66, -4.37 out-out-out SNCooo out-out ActLoopNT-out 8.382 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -72.44, -33.04 APE9-dihe-na -83.46, 25.61 APE8-dihe-out -151.0, 10.45 APE8-rot-in 297.95 APE67-dihe-in -66.52, -19.91 -69.09, -32.84 APE12-dist-in 11.217 APE11-dist-out 14.75 APE10-dist-out 18.32 APE9-dist-out 10.404 None None None XRAY 3.3 0.24 0.288 B 307 276 0 0 0 0 [[457, 716]] 1.0 3tv6 Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4E4XA P15056 448 721 766.0 T1Q:801 Type1.5_Back Inactive DFGin 5.415 13.363 BLAplus -131.88, 173.14 75.18, 30.58 -101.82, -10.02 55.81, 83.67 -117.53, 134.84 out-out out 11.598 Saltbr-out 10.556 HRD-in -63.36, -55.37 84.27, -20.39 out-out-out SNCooo out-out ActLoopNT-out 8.693 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -122.89, -73.39 APE9-dihe-na -70.95, 32.47 APE8-dihe-out -146.48, 22.51 APE8-rot-out 45.91 APE67-dihe-in -65.86, -22.59 -84.31, -22.16 APE12-dist-none 999.0 APE11-dist-out 14.616 APE10-dist-out 18.31 APE9-dist-out 11.183 None None None XRAY 3.6 0.275 0.315 A 307 267 7 0 0 7 [[457, 716]] 1.0 4e4x Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4E4XB P15056 448 721 766.0 T1Q:801 Type1.5_Back Inactive DFGin 5.416 13.351 BLAplus -132.24, 173.33 74.51, 29.59 -99.47, -9.48 56.23, 83.84 -121.9, 128.32 out-out out 11.602 Saltbr-out 10.548 HRD-in -63.26, -55.6 84.82, -20.39 out-out-out SNCooo out-out ActLoopNT-out 8.694 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -123.17, -73.01 APE9-dihe-na -71.52, 32.88 APE8-dihe-out -146.5, 22.32 APE8-rot-out 45.55 APE67-dihe-in -65.69, -23.22 -84.43, -21.74 APE12-dist-in 11.291 APE11-dist-out 14.588 APE10-dist-out 18.297 APE9-dist-out 11.19 None None None XRAY 3.6 0.275 0.315 B 307 274 0 0 0 0 [[457, 716]] 1.0 4e4x Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4EHEA P15056 448 723 766.0 RI8:801 Type1.5_Back Inactive DFGin 5.048 13.184 BLAplus -125.98, -178.47 62.84, 29.19 -94.42, -4.71 59.77, 96.5 -101.0, 165.52 out-out out 11.944 Saltbr-out 10.778 HRD-in -64.88, -47.02 61.07, 32.78 out-out-out SNCooo out-out ActLoopNT-out 8.737 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 118.03 APE9-dihe-na 87.24, 14.12 APE8-dihe-out -132.26, 44.88 APE8-rot-out 37.19 APE67-dihe-in -55.75, -26.88 -67.03, -34.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.019 APE9-dist-out 11.158 None None None XRAY 3.3 0.228 0.296 A 307 266 10 0 0 10 [[457, 716]] 1.0 4ehe Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4EHEB P15056 448 723 766.0 RI8:801 Type1.5_Back Inactive DFGin 5.529 13.841 BLAplus -127.25, -168.5 56.47, 32.77 -102.51, 8.59 61.37, 88.08 -68.29, -97.55 out-out out 11.86 Saltbr-out 11.0 HRD-in -73.09, -51.91 79.83, -18.55 out-out-out SNCooo out-out ActLoopNT-out 8.714 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -63.16, -31.12 APE9-dihe-na -64.6, -10.1 APE8-dihe-out -150.53, 33.92 APE8-rot-out 19.79 APE67-dihe-in -56.94, -33.52 -58.48, -40.21 APE12-dist-in 11.294 APE11-dist-out 14.993 APE10-dist-out 18.447 APE9-dist-out 10.035 None None None XRAY 3.3 0.228 0.296 B 307 276 0 0 0 0 [[457, 716]] 1.0 4ehe Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4PP7A P15056 448 721 766.0 2VX:801 Type1.5_Back Inactive DFGin 5.063 13.55 BLAplus -144.36, -179.4 70.84, 11.79 -79.39, -18.32 64.06, 95.8 -64.87, 163.13 out-out out 11.819 Saltbr-out 9.898 HRD-in -60.94, -49.15 74.91, 0.91 out-out-out SNCooo out-out ActLoopNT-out 8.882 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -161.63, 37.41 APE9-dihe-na -160.85, -8.39 APE8-dihe-out -110.61, 12.59 APE8-rot-in 299.45 APE67-dihe-in -61.85, -28.03 -37.74, -49.88 APE12-dist-none 999.0 APE11-dist-out 14.074 APE10-dist-out 17.73 APE9-dist-out 10.587 None None None XRAY 3.4 0.198 0.254 A 307 267 7 0 0 7 [[457, 716]] 1.0 4pp7 Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4PP7B P15056 448 721 766.0 2VX:801 Type1.5_Back Inactive DFGin 5.575 13.855 BLAplus -143.27, -178.26 56.82, 45.93 -107.94, -13.37 54.78, 79.55 -65.66, 171.36 out-out out 11.418 Saltbr-out 10.581 HRD-in -65.31, -43.62 75.45, -24.33 out-out-out SNCooo out-out ActLoopNT-out 8.573 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -59.94, -29.73 APE9-dihe-na -89.39, 13.82 APE8-dihe-out -141.1, 5.05 APE8-rot-in 299.07 APE67-dihe-in -66.69, -31.17 -60.83, -30.61 APE12-dist-in 11.426 APE11-dist-out 15.016 APE10-dist-out 18.533 APE9-dist-out 10.452 None None None XRAY 3.4 0.198 0.254 B 307 274 0 0 0 0 [[457, 716]] 1.0 4pp7 Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 8VYSA P15056 235 738 766.0 A1AEN:801 Type1.5_Back Inactive DFGin 6.682 13.203 BLAplus -142.03, -178.59 74.92, 8.76 -86.61, -7.69 62.8, 83.25 -71.31, -163.31 out-out out 11.734 Saltbr-out 10.677 HRD-out -77.69, 104.1 -73.86, -30.17 out-out-out SNCooo out-out ActLoopNT-out 9.159 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 7.34 APE8-dihe-out -101.13, 17.39 APE8-rot-out 182.67 APE67-dihe-in -57.56, -44.9 -61.0, -42.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.066 V600E SEP365,SEP729 SEP365,SEP729 EM 3.06 999.0 999.0 A 767 311 38 0 0 13 [[457, 716]] 1.0 8vys Homo sapiens TKL_BRAF_HUMAN TKL 2.9e-81 279.2 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3SKCA P15056 448 723 766.0 BR2:801 Type1 Inactive DFGin 6.265 14.373 BLBminus -140.28, 169.02 94.82, 74.85 -82.48, -134.09 285.7, 0.62 -102.42, 999.0 out-out out 11.319 Saltbr-out 11.094 HRD-in -72.66, -48.6 73.69, 2.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -166.13, -26.66 APE9-dihe-na -100.41, 9.29 APE8-dihe-out -157.77, 40.44 APE8-rot-out 36.63 APE67-dihe-in -70.95, -19.94 -78.93, -17.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.339 None None None XRAY 3.2 0.235 0.271 A 307 260 16 0 0 16 [[457, 716]] 1.0 3skc Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4E26B P15056 448 722 766.0 734:801 Type1 Inactive DFGin 6.361 14.26 BLBminus -129.24, -167.87 46.52, 96.15 -111.58, -138.63 293.59, 65.8 80.77, -62.67 in-in in 8.043 Saltbr-in 3.038 HRD-in -58.73, -54.71 74.73, 10.01 in-in-out SNCiio in-out ActLoopNT-in 2.844 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -177.61 APE9-dihe-na -153.13, 152.76 APE8-dihe-out -144.56, 37.84 APE8-rot-in 294.76 APE67-dihe-in -56.79, -31.94 -61.82, -28.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.722 APE9-dist-out 10.434 None None None XRAY 2.55 0.22 0.262 B 307 264 11 0 0 11 [[457, 716]] 1.0 4e26 Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5HIEA P15056 449 722 766.0 P06:801 Type1 Inactive DFGin 8.929 14.448 BLBminus -141.8, -164.77 53.26, 57.86 -65.92, 138.13 285.18, 76.08 -69.2, 130.11 out-out out 15.725 Saltbr-out 12.5 HRD-in -60.62, -46.76 71.26, -9.44 out-out-out SNCooo out-out ActLoopNT-out 12.738 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 143.17 APE8-dihe-in -83.81, 99.59 APE8-rot-in 302.38 APE67-dihe-in -53.53, -27.96 -85.37, -23.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.176 None None None XRAY 3.0 0.196 0.221 A 302 258 11 0 0 11 [[457, 716]] 1.0 5hie Homo sapiens TKL_BRAF_HUMAN TKL 5.8e-80 274.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5HIEB P15056 449 722 766.0 P06:801 Type1 Inactive DFGin 9.077 14.341 BLBminus -142.86, -164.65 53.45, 58.39 -66.51, 138.76 285.5, 75.66 -69.99, 128.6 out-out out 16.44 Saltbr-out 12.325 HRD-in -61.23, -46.57 70.13, -7.74 out-out-out SNCooo out-out ActLoopNT-out 12.525 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 61.11 APE9-dihe-na -158.28, 177.47 APE8-dihe-in -84.39, 102.56 APE8-rot-in 300.94 APE67-dihe-in -53.91, -28.83 -85.61, -22.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.135 APE9-dist-out 9.836 None None None XRAY 3.0 0.196 0.221 B 302 259 10 0 0 10 [[457, 716]] 1.0 5hie Homo sapiens TKL_BRAF_HUMAN TKL 5.8e-80 274.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5HIEC P15056 449 722 766.0 P06:801 Type1 Inactive DFGin 10.205 14.448 BLBminus -142.24, -163.89 53.8, 57.5 -66.04, 139.53 285.14, 75.68 -75.41, 148.8 out-out out 16.307 Saltbr-out 11.857 HRD-in -60.99, -45.77 71.53, -8.16 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 139.61 APE9-dihe-na 88.59, -130.66 APE8-dihe-in -113.06, 104.87 APE8-rot-in 299.6 APE67-dihe-in -52.68, -29.4 -86.36, -21.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.111 APE9-dist-out 10.018 None None None XRAY 3.0 0.196 0.221 C 302 253 16 0 0 16 [[457, 716]] 1.0 5hie Homo sapiens TKL_BRAF_HUMAN TKL 5.8e-80 274.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5HIED P15056 449 722 766.0 P06:801 Type1 Inactive DFGin 10.028 14.32 BLBminus -141.99, -164.94 53.95, 58.44 -66.89, 145.64 284.8, 75.43 -81.74, 146.41 out-out out 15.147 Saltbr-out 11.827 HRD-in -60.57, -44.96 73.09, -9.93 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -51.59 APE9-dihe-na 147.01, -158.11 APE8-dihe-in -84.1, 102.2 APE8-rot-in 299.84 APE67-dihe-in -53.01, -29.18 -85.5, -22.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.012 APE9-dist-out 9.79 None None None XRAY 3.0 0.196 0.221 D 302 253 16 0 0 16 [[457, 716]] 1.0 5hie Homo sapiens TKL_BRAF_HUMAN TKL 5.8e-80 274.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7P3VA P15056 448 719 766.0 5I4:60801 Type1.5_Back Inactive DFGin 6.573 13.864 BLBminus -132.28, -174.45 67.47, 52.83 -58.57, 159.1 307.91, 177.77 -106.73, 178.46 out-out out 11.321 Saltbr-out 9.99 HRD-in -69.94, -53.92 84.86, -4.8 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 46.37 APE8-dihe-out -133.02, 7.4 APE8-rot-in 305.9 APE67-dihe-in -60.12, -27.16 -57.18, -32.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 24.606 V600E None None XRAY 2.37 0.199 0.247 A 275 255 17 0 0 17 [[457, 716]] 1.0 7p3v Homo sapiens TKL_BRAF_HUMAN TKL 4.4e-84 288.1 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7P3VB P15056 448 719 766.0 5I4:60801 Type1.5_Back Inactive DFGin 6.599 14.065 BLBminus -139.7, -168.52 56.89, 64.51 -61.24, 134.6 284.56, 99.09 -59.19, 165.99 out-out out 10.205 Saltbr-out 8.783 HRD-in -73.95, -50.21 81.58, -8.37 out-out-out SNCooo out-out ActLoopNT-out 9.015 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -57.16, -48.45 APE9-dihe-na -92.46, 16.67 APE8-dihe-out -115.27, 2.88 APE8-rot-in 311.42 APE67-dihe-in -57.19, -21.5 -69.31, -33.03 APE12-dist-out 16.021 APE11-dist-out 17.041 APE10-dist-out 19.183 APE9-dist-out 27.818 V600E None None XRAY 2.37 0.199 0.247 B 275 272 0 0 0 0 [[457, 716]] 1.0 7p3v Homo sapiens TKL_BRAF_HUMAN TKL 4.4e-84 288.1 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4CQEB P15056 448 720 766.0 CQE:1721 Type1.5_Back Inactive DFGin 6.311 14.132 BLBminus -125.28, -175.92 54.18, 61.71 -63.93, 129.8 306.56, 14.82 132.95, 999.0 in-out in 9.88 Saltbr-out 5.188 HRD-in -79.1, -45.33 81.44, -17.5 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -28.49 APE8-dihe-out -103.79, 5.93 APE8-rot-in 295.43 APE67-dihe-in -65.51, -22.37 -48.65, -48.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.803 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.3 0.21 0.255 B 278 248 25 0 0 18 [[457, 716]] 1.0 4cqe Homo sapiens TKL_BRAF_HUMAN TKL 4.5e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4XV2A P15056 449 705 766.0 P06:60801 Type1.5_Back Inactive DFGin 6.763 13.948 BLBminus -133.93, -165.69 64.07, 52.33 -63.95, 158.03 294.89, 175.12 -66.38, 999.0 out-out out 10.344 Saltbr-out 7.452 HRD-in -71.95, -45.63 74.38, -8.24 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -20.37 APE8-dihe-in -98.15, 73.68 APE8-rot-out 55.31 APE67-dihe-in -65.42, -22.32 -89.03, -12.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.993 S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R None None XRAY 2.5 0.213 0.244 A 292 232 25 0 0 18 [[457, 716]] 1.0 4xv2 Homo sapiens TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4XV2B P15056 448 705 766.0 P06:60801 Type1.5_Back Inactive DFGin 6.819 13.774 BLBminus -141.76, -166.98 57.02, 61.55 -73.62, 172.94 297.53, 174.93 -94.28, 999.0 in-out in 9.976 Saltbr-out 8.713 HRD-in -67.71, -52.17 77.27, -8.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -11.01 APE8-dihe-out -79.14, 4.89 APE8-rot-in 319.95 APE67-dihe-in -63.35, -27.69 -53.48, -40.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.112 S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R None None XRAY 2.5 0.213 0.244 B 292 234 24 0 0 18 [[457, 716]] 1.0 4xv2 Homo sapiens TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5CSWB P15056 447 721 766.0 P06:801 Type1.5_Back Inactive DFGin 6.566 14.173 BLBminus -145.39, -140.94 43.16, 61.8 -68.34, 137.1 284.56, 18.12 -76.08, 152.66 out-out out 10.713 Saltbr-out 8.739 HRD-in -69.52, -52.78 80.79, -11.78 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -28.45 APE8-rot-in 308.43 APE67-dihe-in -56.08, -31.02 -67.74, -22.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 2.66 0.22 0.282 B 282 252 23 0 0 18 [[457, 716]] 1.0 5csw Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6V2UB P15056 449 720 766.0 P06:801 Type1.5_Back Inactive DFGin 6.762 13.777 BLBminus -153.94, -155.26 51.92, 62.16 -71.1, 141.57 289.52, 177.82 -77.09, 149.3 out-out out 10.592 Saltbr-out 8.699 HRD-in -70.71, -52.85 79.91, -12.49 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -21.81 APE8-rot-in 289.14 APE67-dihe-in -65.05, -25.48 -78.98, -16.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.78 0.282 0.309 B 283 250 22 0 0 18 [[457, 716]] 1.0 6v2u Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 9AXYA P15056 448 722 766.0 ANP:801 ATPlike Inactive DFGin 5.917 13.541 BLBplus -133.51, 174.13 59.27, 33.71 -86.77, 154.56 49.71, 87.92 69.37, -142.48 out-out out 14.096 Saltbr-out 13.007 HRD-in -70.93, -41.64 75.57, -39.02 out-out-out SNCooo out-out ActLoopNT-out 9.069 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -141.06, 145.96 APE9-dihe-na 71.75, -130.61 APE8-dihe-in -87.56, 149.58 APE8-rot-out 200.58 APE67-dihe-in -69.57, -29.74 -96.77, -9.15 APE12-dist-out 14.194 APE11-dist-out 15.515 APE10-dist-out 11.663 APE9-dist-out 9.677 None None None XRAY 3.6 0.19 0.237 A 280 275 0 0 0 0 [[457, 716]] 1.0 9axy Homo sapiens TKL_BRAF_HUMAN TKL 7.8e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6PP9A P15056 447 722 766.0 ANP:801 ATPlike Inactive DFGin 5.342 13.498 BLBplus -130.79, 177.54 57.37, 43.96 -96.57, 156.54 49.86, 89.0 63.47, -135.71 out-out out 14.313 Saltbr-out 12.69 HRD-in -66.97, -47.8 65.51, 3.6 out-out-out SNCooo out-out ActLoopNT-out 9.256 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -142.44, 146.23 APE9-dihe-na 73.26, -154.57 APE8-dihe-in -71.36, 154.2 APE8-rot-out 182.15 APE67-dihe-in -61.64, -19.53 -112.25, -5.75 APE12-dist-out 15.201 APE11-dist-out 15.9 APE10-dist-out 12.693 APE9-dist-out 10.139 None None None XRAY 2.59 0.222 0.245 A 283 276 0 0 0 0 [[457, 716]] 1.0 6pp9 Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6V2WA P15056 447 721 766.0 ANP:801 ATPlike Inactive DFGin 5.532 13.704 BLBplus -135.72, 175.83 57.63, 35.46 -91.96, 158.82 53.8, 96.09 64.15, -137.39 out-out out 14.475 Saltbr-out 12.433 HRD-in -69.37, -44.53 66.04, 8.13 out-out-out SNCooo out-out ActLoopNT-out 8.99 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -146.39, 170.31 APE9-dihe-na 111.41, -172.95 APE8-dihe-in -92.84, 135.37 APE8-rot-out 52.69 APE67-dihe-in -65.1, -26.74 -72.43, -22.76 APE12-dist-out 14.729 APE11-dist-out 14.898 APE10-dist-out 12.159 APE9-dist-out 6.256 None None None XRAY 3.12 0.189 0.237 A 283 275 0 0 0 0 [[457, 716]] 1.0 6v2w Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7M0TA P15056 448 721 766.0 ANP:801 ATPlike Inactive DFGin 5.483 13.645 BLBplus -101.53, -171.54 49.12, 40.35 -93.39, 158.36 49.68, 91.24 67.74, -141.33 out-out out 14.633 Saltbr-out 13.418 HRD-in -63.36, -50.98 81.19, -14.99 out-out-out SNCooo out-out ActLoopNT-out 9.096 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iooo APE10-dihe-na -146.63, 169.35 APE9-dihe-na 113.78, -178.56 APE8-dihe-in -87.12, 141.18 APE8-rot-out 208.64 APE67-dihe-out -59.38, 160.81 -70.93, -34.96 APE12-dist-in 13.663 APE11-dist-out 15.277 APE10-dist-out 12.449 APE9-dist-out 6.689 None None None XRAY 3.19 0.199 0.254 A 283 274 0 0 0 0 [[457, 716]] 1.0 7m0t Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7M0UA P15056 449 722 766.0 ANP:801 ATPlike Inactive DFGin 5.826 13.545 BLBplus -114.76, -174.76 53.19, 33.71 -86.73, 158.23 49.19, 93.22 61.58, -136.88 out-out out 14.508 Saltbr-out 13.628 HRD-in -66.62, -51.93 79.28, -5.3 out-out-out SNCooo out-out ActLoopNT-out 8.968 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -137.94, 171.17 APE9-dihe-na 125.59, 173.92 APE8-dihe-in -78.53, 136.46 APE8-rot-out 49.62 APE67-dihe-in -63.36, -26.84 -75.55, -22.51 APE12-dist-out 14.59 APE11-dist-out 14.476 APE10-dist-out 12.102 APE9-dist-out 6.331 None None None XRAY 3.09 0.193 0.23 A 283 274 0 0 0 0 [[457, 716]] 1.0 7m0u Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7M0VA P15056 449 722 766.0 ANP:801 ATPlike Inactive DFGin 5.741 13.29 BLBplus -118.84, -178.01 61.17, 44.22 -99.98, 160.93 40.29, 99.45 62.33, -140.62 out-out out 14.111 Saltbr-out 13.141 HRD-in -76.68, -47.66 79.51, -34.29 out-out-out SNCooo out-out ActLoopNT-out 9.324 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -140.71, 145.59 APE9-dihe-na 81.77, -131.39 APE8-dihe-in -106.29, 148.31 APE8-rot-out 201.4 APE67-dihe-in -54.29, -30.39 -107.29, -13.89 APE12-dist-in 13.909 APE11-dist-out 15.777 APE10-dist-out 12.613 APE9-dist-out 10.163 None None None XRAY 3.16 0.188 0.234 A 283 274 0 0 0 0 [[457, 716]] 1.0 7m0v Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7M0WA P15056 448 721 766.0 ANP:801 ATPlike Inactive DFGin 5.7 13.563 BLBplus -128.57, -174.24 58.52, 36.11 -93.32, 163.98 47.26, 91.72 57.0, -141.37 out-out out 14.273 Saltbr-out 13.044 HRD-in -64.47, -50.11 78.2, -6.17 out-out-out SNCooo out-out ActLoopNT-out 8.98 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -140.16, 158.71 APE9-dihe-na 121.26, -178.69 APE8-dihe-in -87.94, 138.93 APE8-rot-out 43.99 APE67-dihe-in -65.6, -30.89 -79.08, -13.62 APE12-dist-out 14.335 APE11-dist-out 15.342 APE10-dist-out 12.134 APE9-dist-out 6.651 None None None XRAY 3.09 0.197 0.233 A 283 274 0 0 0 0 [[457, 716]] 1.0 7m0w Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7M0XA P15056 447 722 766.0 ANP:801 ATPlike Inactive DFGin 5.445 13.495 BLBplus -123.82, 174.92 60.79, 42.33 -96.45, 161.16 49.04, 90.67 58.85, -140.33 out-out out 14.265 Saltbr-out 13.063 HRD-in -65.53, -50.34 78.03, -10.0 out-out-out SNCooo out-out ActLoopNT-out 9.245 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -141.24, 149.26 APE9-dihe-na 65.43, -162.66 APE8-dihe-in -61.59, 142.77 APE8-rot-out 179.57 APE67-dihe-in -62.52, -26.23 -97.92, -3.07 APE12-dist-out 15.152 APE11-dist-out 15.966 APE10-dist-out 12.626 APE9-dist-out 10.084 None None None XRAY 2.47 0.18 0.215 A 283 276 0 0 0 0 [[457, 716]] 1.0 7m0x Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7M0YA P15056 447 721 766.0 ANP:801 ATPlike Inactive DFGin 5.925 13.72 BLBplus -130.12, 178.08 53.67, 39.87 -94.09, 143.26 51.07, 86.66 77.46, -140.33 out-out out 14.454 Saltbr-out 12.42 HRD-in -66.6, -53.86 81.89, -14.1 out-out-out SNCooo out-out ActLoopNT-out 8.968 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -138.96, 162.77 APE9-dihe-na 110.62, -175.34 APE8-dihe-in -77.87, 138.5 APE8-rot-out 52.44 APE67-dihe-in -64.93, -32.89 -83.52, -17.07 APE12-dist-out 14.226 APE11-dist-out 15.27 APE10-dist-out 12.007 APE9-dist-out 6.781 None None None XRAY 3.45 0.196 0.218 A 283 275 0 0 0 0 [[457, 716]] 1.0 7m0y Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7M0ZA P15056 449 721 766.0 ANP:801 ATPlike Inactive DFGin 5.591 13.558 BLBplus -131.23, -177.35 57.24, 31.09 -88.02, 155.4 49.99, 89.35 66.37, -137.56 out-out out 14.378 Saltbr-out 12.797 HRD-in -63.1, -49.11 70.7, -2.29 out-out-out SNCooo out-out ActLoopNT-out 8.934 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -140.88, 158.66 APE9-dihe-na 126.45, -167.01 APE8-dihe-in -93.79, 132.25 APE8-rot-out 208.38 APE67-dihe-in -66.35, -24.31 -75.16, -20.55 APE12-dist-in 12.987 APE11-dist-out 14.918 APE10-dist-out 11.822 APE9-dist-out 6.385 None None None XRAY 3.12 0.193 0.225 A 283 273 0 0 0 0 [[457, 716]] 1.0 7m0z Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 9ECUA P15056 447 722 766.0 ANP:801 ATPlike Inactive DFGin 5.395 13.556 BLBplus -125.65, 169.46 60.46, 40.01 -87.45, 154.95 47.27, 91.45 64.75, -132.56 out-out out 13.975 Saltbr-out 13.736 HRD-in -64.53, -58.29 87.19, -19.63 out-out-out SNCooo out-out ActLoopNT-out 9.233 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -128.75, 123.72 APE9-dihe-na 163.56, -169.21 APE8-dihe-in -104.16, 118.8 APE8-rot-in 298.64 APE67-dihe-in -60.82, -35.98 -59.26, -34.28 APE12-dist-out 14.691 APE11-dist-out 15.132 APE10-dist-out 11.51 APE9-dist-out 6.31 None None None XRAY 3.46 0.202 0.237 A 284 276 0 0 0 0 [[457, 716]] 1.0 9ecu Homo sapiens TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6U2GB P15056 451 722 766.0 ACP:901 ATPlike Inactive DFGin 6.15 13.909 BLBplus -127.14, -173.09 46.65, 53.2 -113.93, 152.92 52.73, 94.7 72.25, -152.99 out-out out 14.606 Saltbr-out 12.705 HRD-in -59.19, -53.53 76.48, -9.73 out-out-out SNCooo out-out ActLoopNT-out 9.495 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -146.07, 161.59 APE9-dihe-na 90.18, -141.72 APE8-dihe-in -101.38, 139.04 APE8-rot-out 180.97 APE67-dihe-in -60.58, -31.67 -70.85, -22.56 APE12-dist-out 15.336 APE11-dist-out 15.709 APE10-dist-out 13.592 APE9-dist-out 9.892 None None None XRAY 2.886 0.231 0.276 B 307 264 8 0 0 8 [[457, 716]] 1.0 6u2g Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6NYBA P15056 233 738 766.0 AGS:60801 ATPlike Inactive DFGin 5.498 13.825 BLBplus -130.99, 171.98 57.42, 47.58 -103.38, 154.64 56.0, 92.93 63.13, -128.72 out-out out 13.824 Saltbr-out 12.604 HRD-in -73.31, -44.18 67.31, 1.32 out-out-out SNCooo out-out ActLoopNT-out 9.065 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -162.22, 166.73 APE9-dihe-na 98.18, -110.24 APE8-dihe-in -136.25, 146.51 APE8-rot-out 61.57 APE67-dihe-in -62.67, -27.04 -119.01, -4.59 APE12-dist-out 14.66 APE11-dist-out 15.641 APE10-dist-out 13.882 APE9-dist-out 8.763 None SEP365,SEP729 SEP365,SEP729 EM 4.1 999.0 999.0 A 805 350 0 0 0 0 [[457, 716]] 1.0 6nyb Homo sapiens TKL_BRAF_HUMAN TKL 1.4e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 8DGSA P15056 155 738 766.0 AGS:60801 ATPlike Inactive DFGin 6.606 13.238 BLBplus -138.09, -166.17 58.48, 64.88 -134.87, 173.46 48.16, 90.78 58.1, -132.32 out-out out 14.522 Saltbr-out 12.258 HRD-in -71.36, -47.09 71.02, -12.92 out-out-out SNCooo out-out ActLoopNT-out 9.554 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -160.2, 161.72 APE9-dihe-na 103.44, -137.95 APE8-dihe-in -102.25, 169.61 APE8-rot-in 312.72 APE67-dihe-in -64.56, -41.44 -121.48, -15.09 APE12-dist-out 14.082 APE11-dist-out 15.843 APE10-dist-out 12.46 APE9-dist-out 8.209 None SEP365,SEP729 SEP365,SEP729 EM 4.3 999.0 999.0 A 805 427 0 0 0 0 [[457, 716]] 1.0 8dgs Homo sapiens TKL_BRAF_HUMAN TKL 1.4e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 8DGTA P15056 151 738 766.0 AGS:60801 ATPlike Inactive DFGin 5.641 13.675 BLBplus -132.23, 178.7 56.78, 46.46 -100.79, 153.62 51.93, 96.21 64.7, -132.47 out-out out 13.923 Saltbr-out 12.693 HRD-in -71.52, -43.55 65.96, -9.54 out-out-out SNCooo out-out ActLoopNT-out 8.998 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -155.42, 128.83 APE9-dihe-na 147.85, 157.58 APE8-dihe-in -55.44, 116.98 APE8-rot-out 39.4 APE67-dihe-in -65.02, -24.91 -67.41, -12.47 APE12-dist-out 14.368 APE11-dist-out 14.543 APE10-dist-out 11.934 APE9-dist-out 6.457 None SEP365,SEP729 SEP365,SEP729 EM 3.9 999.0 999.0 A 805 431 0 0 0 0 [[457, 716]] 1.0 8dgt Homo sapiens TKL_BRAF_HUMAN TKL 1.4e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7MFDA P15056 156 738 766.0 No_ligand No_ligand Inactive DFGin 6.133 14.028 BLBplus -147.17, -167.77 58.95, 63.63 -141.3, 173.3 63.34, 90.1 84.7, -138.28 out-out out 13.444 Saltbr-out 14.964 HRD-in -65.44, -45.07 53.09, 12.91 out-out-out SNCooo out-out ActLoopNT-out 10.126 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -115.53, 118.71 APE9-dihe-na 124.14, -152.32 APE8-dihe-out -80.3, -174.47 APE8-rot-out 175.42 APE67-dihe-in -88.54, -38.49 -131.9, 1.65 APE12-dist-in 12.524 APE11-dist-out 15.293 APE10-dist-out 11.941 APE9-dist-out 9.006 None SEP365,SEP729 SEP365,SEP729 EM 3.66 999.0 999.0 A 766 410 0 0 0 0 [[457, 716]] 1.0 7mfd Homo sapiens TKL_BRAF_HUMAN TKL 1.3e-80 277.1 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7MFEA P15056 156 738 766.0 No_ligand No_ligand Inactive DFGin 5.592 14.077 BLBplus -177.8, -165.52 58.54, 65.19 -141.16, 177.04 83.19, 84.53 83.39, -159.89 out-out out 13.98 Saltbr-out 13.724 HRD-in -67.64, -50.06 72.14, -8.98 out-out-out SNCooo out-out ActLoopNT-out 9.848 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -158.83, 165.63 APE9-dihe-na 60.73, -126.1 APE8-dihe-in -116.98, 164.64 APE8-rot-out 62.4 APE67-dihe-in -73.69, -58.3 -108.21, 16.9 APE12-dist-in 13.855 APE11-dist-out 15.971 APE10-dist-out 12.319 APE9-dist-out 8.857 None SEP365,SEP729 SEP365,SEP729 EM 4.07 999.0 999.0 A 766 409 0 0 0 0 [[457, 716]] 1.0 7mfe Homo sapiens TKL_BRAF_HUMAN TKL 1.3e-80 277.1 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 9O2ZA P15056 156 738 766.0 No_ligand No_ligand Inactive DFGin 5.227 14.852 BLBplus -158.75, -165.27 58.03, 65.17 -135.36, 168.35 93.37, 94.37 65.45, -126.84 out-out out 14.181 Saltbr-out 12.733 HRD-in -63.04, -43.06 56.11, 7.15 out-out-out SNCooo out-out ActLoopNT-out 10.052 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -122.26, 135.07 APE9-dihe-na 116.39, -152.99 APE8-dihe-in -82.69, 172.63 APE8-rot-out 176.75 APE67-dihe-in -65.4, -27.16 -118.54, -27.57 APE12-dist-in 12.399 APE11-dist-out 15.332 APE10-dist-out 12.287 APE9-dist-out 9.286 None SEP365,SEP729 SEP365,SEP729 EM 3.83 999.0 999.0 A 766 412 0 0 0 0 [[457, 716]] 1.0 9o2z Homo sapiens TKL_BRAF_HUMAN TKL 1.3e-80 277.1 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 8VYOA P15056 235 738 766.0 No_ligand No_ligand Inactive DFGin 6.329 11.959 BLBplus -106.72, -170.53 56.46, 17.56 -67.21, 152.55 41.04, 73.92 52.43, -143.18 out-out out 14.4 Saltbr-out 10.253 HRD-in -71.72, -18.44 66.71, -45.69 out-out-out SNCooo out-out ActLoopNT-out 8.463 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -118.68 APE8-dihe-in -140.61, 156.59 APE8-rot-out 63.25 APE67-dihe-out -119.23, -9.19 -147.56, 106.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.692 None SEP365,SEP729 SEP365,SEP729 EM 3.74 999.0 999.0 A 767 309 19 0 0 12 [[457, 716]] 1.0 8vyo Homo sapiens TKL_BRAF_HUMAN TKL 1.3e-80 277.1 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3C4CA P15056 448 721 766.0 324:60002 Type1.5_Back Inactive DFGin 5.638 13.547 BLBplus -139.33, -169.83 64.62, 39.85 -103.64, 171.83 60.3, 95.42 83.99, 999.0 out-out out 11.62 Saltbr-out 8.693 HRD-in -73.87, -57.97 102.26, -19.82 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, -163.04 APE9-dihe-na -121.17, -138.04 APE8-dihe-in -92.13, 91.4 APE8-rot-out 47.35 APE67-dihe-in -63.77, -25.31 -68.49, -17.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.55 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 2.57 0.261 0.303 A 280 257 17 0 0 17 [[457, 716]] 1.0 3c4c Homo sapiens TKL_BRAF_HUMAN TKL 4.5e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4XV3B P15056 448 705 766.0 No_ligand No_ligand Inactive DFGin 6.285 15.063 None -134.59, -161.64 56.33, 52.08 -63.4, 999.0 279.75, 63.83 999.0, 999.0 in-in in 8.928 Saltbr-in 3.324 HRD-in -65.71, -41.29 62.65, 10.76 in-in-out SNCiio in-out ActLoopNT-in 2.983 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -32.28 APE8-dihe-out -76.54, 7.27 APE8-rot-in 304.4 APE67-dihe-in -61.73, -25.86 -63.95, -33.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.701 S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R None None XRAY 2.8 0.26 0.296 B 292 225 33 0 0 16 [[457, 716]] 1.0 4xv3 Homo sapiens TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4FK3B P15056 448 721 766.0 No_ligand No_ligand Inactive DFGin 5.772 14.711 None -140.8, -152.47 49.25, 52.94 -56.33, -72.64 272.7, 56.86 47.33, -79.68 in-out in 9.045 Saltbr-out 5.373 HRD-in -75.07, -44.36 65.22, -1.5 out-in-out SNCoio in-out ActLoopNT-in 3.194 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 141.11 APE9-dihe-na 86.3, -24.42 APE8-dihe-out -101.18, 22.22 APE8-rot-out 89.79 APE67-dihe-in -68.94, -26.21 -73.51, -33.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.132 APE9-dist-out 11.411 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.65 0.262 0.315 B 292 257 17 0 0 13 [[457, 716]] 1.0 4fk3 Homo sapiens TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3OG7B P15056 449 720 766.0 No_ligand No_ligand Inactive DFGin 5.961 14.384 None -166.94, -137.57 40.92, 51.52 -52.94, -84.66 283.54, 98.08 68.73, -46.65 in-in in 8.951 Saltbr-in 2.588 HRD-in -73.27, -47.93 73.19, 0.79 in-in-out SNCiio in-out ActLoopNT-in 2.969 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -31.76 APE8-dihe-out -68.94, -9.04 APE8-rot-in 313.5 APE67-dihe-in -62.19, -30.71 -52.08, -39.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.037 K522A,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 2.45 0.214 0.258 B 289 254 18 0 0 14 [[457, 716]] 1.0 3og7 Homo sapiens TKL_BRAF_HUMAN TKL 1.2e-83 286.6 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6UUOA P15056 450 722 766.0 QH1:801 Type1 Inactive DFGin 5.483 13.575 None -154.98, -157.82 59.8, 46.61 -126.81, 999.0 56.6, 86.97 999.0, 999.0 out-none out 10.441 Saltbr-none 999.0 HRD-out -76.54, 102.1 -78.95, -33.04 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -71.64, -31.02 APE9-dihe-na -70.11, -42.33 APE8-dihe-out -89.38, 32.83 APE8-rot-in 313.94 APE67-dihe-in -71.42, -39.61 -73.97, -40.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 28.326 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.288 0.265 0.288 A 284 254 19 0 0 14 [[457, 716]] 1.0 6uuo Homo sapiens TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4H58A P15056 448 722 766.0 10Z:60801 Type1 Inactive DFGin 5.96 13.722 None -110.59, -118.32 -39.31, 108.26 -95.89, 11.56 277.46, 88.25 -35.77, -74.73 in-in in 8.302 Saltbr-in 2.764 HRD-in -69.13, -43.65 65.49, 6.98 in-in-out SNCiio in-out ActLoopNT-in 2.835 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnio APE10-dihe-na 999.0, 79.67 APE9-dihe-na -70.74, 22.44 APE8-dihe-in -101.01, 94.21 APE8-rot-in 260.42 APE67-dihe-in -50.49, -22.55 -89.83, -41.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.565 APE9-dist-out 10.307 None None None XRAY 3.1 0.224 0.272 A 275 263 12 0 0 12 [[457, 716]] 1.0 4h58 Homo sapiens TKL_BRAF_HUMAN TKL 7.3e-82 280.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3PRFB P15056 448 723 766.0 FP3:727 Type1 Inactive DFGin 6.428 13.643 None -169.57, 116.91 168.47, 123.69 -125.85, 47.13 283.69, 79.02 -70.43, 82.93 in-in in 8.154 Saltbr-in 2.997 HRD-in -67.72, -35.03 62.32, -6.1 in-out-out SNCioo out-out ActLoopNT-out 5.602 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -169.48 APE8-dihe-in -103.48, 122.52 APE8-rot-in 275.2 APE67-dihe-in -59.13, -20.14 -98.86, -20.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.526 None None None XRAY 2.9 0.271 0.31 B 307 262 14 0 0 14 [[457, 716]] 1.0 3prf Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5CSWA P15056 449 721 766.0 P06:801 Type1.5_Back Inactive DFGin 6.563 13.725 None -154.89, -152.27 52.45, 58.54 -68.5, 999.0 303.98, 168.7 999.0, 999.0 out-out out 10.269 Saltbr-out 7.429 HRD-in -64.98, -59.02 86.25, -16.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 30.46 APE8-dihe-out -158.22, 46.88 APE8-rot-in 285.64 APE67-dihe-in -66.32, -23.33 -79.02, -14.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.364 R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 2.66 0.22 0.282 A 282 254 19 0 0 19 [[457, 716]] 1.0 5csw Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5ITAB P15056 448 721 766.0 6DC:801 Type1.5_Back Inactive DFGin 5.363 13.803 None -122.71, -173.14 61.94, 63.43 -148.55, 999.0 64.56, 89.23 999.0, 999.0 out-in out 10.351 Saltbr-in 3.533 HRD-in -69.84, -55.2 76.82, -4.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, -11.31 APE9-dihe-na -82.19, 19.66 APE8-dihe-out -126.85, 23.68 APE8-rot-in 305.8 APE67-dihe-in -61.03, -25.66 -65.06, -28.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.333 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 1.95 0.197 0.244 B 297 252 22 0 0 18 [[457, 716]] 1.0 5ita Homo sapiens TKL_BRAF_HUMAN TKL 5.7e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6V2UA P15056 449 721 766.0 P06:801 Type1.5_Back Inactive DFGin 6.785 13.871 None -154.67, -156.07 52.1, 63.13 -70.26, 999.0 290.51, 178.01 999.0, 999.0 out-none out 10.27 Saltbr-none 999.0 HRD-in -70.43, -53.73 79.13, -11.56 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, -132.33 APE9-dihe-na -124.36, 116.11 APE8-dihe-in -169.83, 67.75 APE8-rot-in 288.88 APE67-dihe-in -62.03, -24.27 -79.94, -15.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.486 None None None XRAY 3.78 0.282 0.309 A 283 255 18 0 0 18 [[457, 716]] 1.0 6v2u Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4MBJA P15056 448 723 766.0 DFS:801 Type1.5_Back Inactive DFGin 5.04 14.172 None -105.17, -97.55 -92.89, 45.25 -92.17, -5.13 71.79, 75.67 -66.15, 168.52 out-out out 11.905 Saltbr-out 10.125 HRD-in -75.95, -40.1 71.4, -7.47 out-out-out SNCooo out-out ActLoopNT-out 8.69 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na 173.82, -65.98 APE9-dihe-na -61.43, -19.22 APE8-dihe-in -120.24, 91.44 APE8-rot-out 31.9 APE67-dihe-in -51.31, -26.45 -118.43, -32.49 APE12-dist-none 999.0 APE11-dist-out 14.519 APE10-dist-out 17.705 APE9-dist-out 11.07 None None None XRAY 3.6 0.276 0.328 A 304 269 7 0 0 7 [[457, 716]] 1.0 4mbj Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4MBJB P15056 448 723 766.0 DFS:801 Type1.5_Back Inactive DFGin 5.023 14.149 None -106.4, -95.1 -95.18, 47.42 -92.84, -5.68 72.56, 75.57 -66.19, 170.04 out-out out 11.925 Saltbr-out 10.201 HRD-in -72.66, -45.72 76.66, -7.37 out-out-out SNCooo out-out ActLoopNT-out 8.704 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na 171.46, -66.25 APE9-dihe-na -61.77, -19.59 APE8-dihe-in -119.83, 90.82 APE8-rot-out 33.61 APE67-dihe-in -51.95, -27.84 -118.81, -32.64 APE12-dist-in 11.252 APE11-dist-out 14.492 APE10-dist-out 17.693 APE9-dist-out 11.058 None None None XRAY 3.6 0.276 0.328 B 304 276 0 0 0 0 [[457, 716]] 1.0 4mbj Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4H58C P15056 449 722 766.0 No_ligand No_ligand Inactive DFGout 12.314 12.229 BBAminus -160.6, -162.0 -123.7, 93.43 -89.2, -0.33 292.68, 81.74 36.99, -133.77 in-in in 7.705 Saltbr-in 2.647 HRD-in -62.88, -49.99 78.35, 6.93 in-out-out SNCioo out-out ActLoopNT-out 18.505 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -120.11, -16.47 APE9-dihe-na -80.65, -129.6 APE8-dihe-in -116.99, 109.87 APE8-rot-in 290.33 APE67-dihe-in -66.58, -13.25 -83.92, -32.56 APE12-dist-out 20.827 APE11-dist-out 17.582 APE10-dist-out 13.409 APE9-dist-out 9.258 None None None XRAY 3.1 0.224 0.272 C 275 272 2 0 0 0 [[457, 716]] 1.0 4h58 Homo sapiens TKL_BRAF_HUMAN TKL 7.3e-82 280.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4G9RB P15056 448 721 766.0 B1E:801 Type1 Inactive DFGout 12.547 11.72 BBAminus -147.94, -171.25 -121.56, 97.8 -91.5, -5.17 309.53, 111.01 -58.05, 149.39 in-in in 8.782 Saltbr-in 2.627 HRD-in -65.66, -45.28 76.96, -21.52 in-out-out SNCioo out-out ActLoopNT-out 13.877 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -133.81 APE8-dihe-in -92.38, 126.95 APE8-rot-in 272.42 APE67-dihe-in -63.84, -25.88 -100.21, -30.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.21 V600E None None XRAY 3.2 0.229 0.277 B 307 261 13 0 0 13 [[457, 716]] 1.0 4g9r Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.2 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5CSXA P15056 448 720 766.0 54J:801 Type1.5_Back Inactive DFGout 13.281 11.102 BBAminus -150.59, -157.43 -140.52, 94.87 -94.05, 9.61 293.76, 75.18 -76.48, 136.85 out-out out 10.528 Saltbr-out 5.656 HRD-in -70.41, -44.57 77.65, -9.55 out-out-out SNCooo out-out ActLoopNT-out 15.571 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -69.23 APE9-dihe-na -103.11, 22.42 APE8-dihe-out -123.47, 4.1 APE8-rot-in 303.94 APE67-dihe-in -63.23, -27.45 -60.87, -31.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.462 APE9-dist-out 10.951 R443P,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 2.51 0.223 0.282 A 282 261 12 0 0 10 [[457, 716]] 1.0 5csx Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 8C7YA P15056 448 721 766.0 TXV:60819 Type2 Inactive DFGout 12.408 11.726 BBAminus -137.73, -175.36 -123.6, 90.82 -84.7, -1.49 298.01, 93.91 -135.43, 40.89 in-in in 8.387 Saltbr-in 2.85 HRD-in -66.11, -47.81 81.15, -13.03 in-out-out SNCioo out-out ActLoopNT-out 14.657 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -57.81, -31.54 APE9-dihe-na -75.2, -3.67 APE8-dihe-out -121.03, -1.94 APE8-rot-in 304.31 APE67-dihe-in -66.09, -22.26 -55.41, -37.84 APE12-dist-in 10.58 APE11-dist-in 10.609 APE10-dist-out 14.146 APE9-dist-out 10.866 V600E None None XRAY 1.65 0.153 0.175 A 282 274 0 0 0 0 [[457, 716]] 1.0 8c7y Homo sapiens TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 8C7YB P15056 449 721 766.0 TXV:60803 Type2 Inactive DFGout 12.204 11.719 BBAminus -146.3, -168.52 -130.63, 88.27 -86.35, -12.6 298.57, 95.44 49.99, -135.3 in-in in 8.379 Saltbr-in 2.775 HRD-in -71.56, -48.93 77.75, -10.34 in-out-out SNCioo out-out ActLoopNT-out 18.062 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 5.82 APE8-dihe-out -125.92, 1.76 APE8-rot-in 306.06 APE67-dihe-in -66.57, -23.27 -61.15, -28.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.759 V600E None None XRAY 1.65 0.153 0.175 B 282 258 15 0 0 15 [[457, 716]] 1.0 8c7y Homo sapiens TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6V34A P15056 449 721 766.0 QOP:60801 Type2 Inactive DFGout 12.434 11.575 BBAminus -154.0, -169.02 -128.32, 93.65 -90.71, 10.51 309.15, 147.81 -68.37, 132.98 in-in in 9.086 Saltbr-in 2.538 HRD-in -69.77, -32.09 68.47, -18.7 in-out-out SNCioo out-out ActLoopNT-out 14.574 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 76.8 APE9-dihe-na -77.41, 65.97 APE8-dihe-in -153.14, 51.16 APE8-rot-in 295.33 APE67-dihe-in -64.54, -20.97 -83.49, -26.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.524 APE9-dist-out 11.638 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 3.15 0.257 0.286 A 283 254 19 0 0 14 [[457, 716]] 1.0 6v34 Homo sapiens TKL_BRAF_HUMAN TKL 4.9e-84 287.9 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6V34B P15056 449 721 766.0 QOP:60801 Type2 Inactive DFGout 12.56 11.92 BBAminus -154.71, -167.6 -127.21, 92.8 -91.69, -108.51 309.26, 147.08 122.27, 999.0 in-in in 9.301 Saltbr-in 2.891 HRD-in -70.04, -32.52 68.23, -18.05 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.85, -18.83 999.0, -26.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 3.15 0.257 0.286 B 283 247 26 0 0 20 [[457, 716]] 1.0 6v34 Homo sapiens TKL_BRAF_HUMAN TKL 4.9e-84 287.9 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4R5YA P15056 449 720 766.0 3K3:801 Type2 Inactive DFGout 12.424 11.403 BBAminus -178.69, -170.96 -106.97, 94.73 -95.79, 9.88 289.99, 76.28 -115.28, 999.0 in-out in 8.866 Saltbr-out 5.529 HRD-in -60.99, -46.63 78.01, -10.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -4.67 APE8-rot-out 203.05 APE67-dihe-in -69.84, -20.28 -83.09, -13.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.5 0.229 0.306 A 292 253 19 0 0 19 [[457, 716]] 1.0 4r5y Homo sapiens TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4R5YB P15056 449 720 766.0 3K3:801 Type2 Inactive DFGout 12.727 11.371 BBAminus -171.56, -169.77 -112.44, 105.89 -99.56, 4.22 290.31, 63.5 -85.76, 129.56 in-out in 8.573 Saltbr-out 5.139 HRD-out -74.44, 104.88 -75.35, 1.11 out-out-out SNCooo out-out ActLoopNT-out 16.506 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -62.43 APE9-dihe-na -110.62, 18.0 APE8-dihe-out -132.72, 21.46 APE8-rot-in 308.12 APE67-dihe-in -68.31, -34.38 -66.71, -16.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.501 APE9-dist-out 10.835 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.5 0.229 0.306 B 292 254 18 0 0 14 [[457, 716]] 1.0 4r5y Homo sapiens TKL_BRAF_HUMAN TKL 5.5e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6XFPA P15056 449 720 766.0 V1Y:801 Type2 Inactive DFGout 12.785 11.794 BBAminus -152.68, -168.04 -122.37, 95.79 -81.47, -2.45 289.34, 78.53 -103.07, -17.89 in-in in 8.82 Saltbr-in 2.68 HRD-in -72.84, -49.41 80.71, -18.06 in-out-out SNCioo out-out ActLoopNT-out 15.912 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -63.42, 112.38 APE9-dihe-na 63.49, 13.54 APE8-dihe-out -120.51, -9.67 APE8-rot-in 293.98 APE67-dihe-in -68.28, -18.63 -59.36, -37.51 APE12-dist-in 10.898 APE11-dist-out 14.068 APE10-dist-out 10.739 APE9-dist-out 10.978 None None None XRAY 2.0 0.207 0.257 A 288 272 0 0 0 0 [[457, 716]] 1.0 6xfp Homo sapiens TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6XLOA P15056 449 720 766.0 V5J:801 Type2 Inactive DFGout 12.584 12.478 BBAminus -143.26, -154.83 -139.35, 81.57 -80.55, 3.31 328.42, 130.67 -78.49, 138.96 in-in in 8.236 Saltbr-in 2.674 HRD-in -62.92, -51.69 76.71, -8.67 in-out-out SNCioo out-out ActLoopNT-out 14.203 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -50.07, -31.4 APE9-dihe-na -91.29, 26.43 APE8-dihe-out -148.42, -12.6 APE8-rot-in 284.88 APE67-dihe-in -62.29, -18.91 -54.15, -42.06 APE12-dist-in 10.361 APE11-dist-in 11.867 APE10-dist-out 13.072 APE9-dist-out 10.899 None None None XRAY 2.493 0.237 0.267 A 288 258 14 0 0 5 [[457, 716]] 1.0 6xlo Homo sapiens TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6XLOB P15056 450 720 766.0 V5J:801 Type2 Inactive DFGout 12.584 12.441 BBAminus -143.08, -155.74 -139.03, 82.3 -80.56, 3.3 327.55, 70.15 -79.44, 140.59 in-in in 8.225 Saltbr-in 2.637 HRD-in -63.28, -51.61 76.36, -9.34 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -12.77 APE8-rot-in 284.58 APE67-dihe-in -62.16, -19.3 -54.01, -41.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.493 0.237 0.267 B 288 250 21 0 0 18 [[457, 716]] 1.0 6xlo Homo sapiens TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7K0VA P15056 449 722 766.0 VQP:801 Type2 Inactive DFGout 12.195 11.918 BBAminus -162.68, -156.07 -117.9, 96.89 -109.54, 16.15 299.04, 103.45 -77.91, 116.59 in-in in 8.676 Saltbr-in 3.148 HRD-in -72.28, -41.59 81.4, -9.83 in-out-out SNCioo out-out ActLoopNT-out 23.093 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -92.4, 141.9 APE9-dihe-na -84.31, -172.93 APE8-dihe-in -81.24, 56.12 APE8-rot-in 309.48 APE67-dihe-in -74.89, -22.92 -59.56, -24.75 APE12-dist-in 9.752 APE11-dist-out 15.297 APE10-dist-out 14.399 APE9-dist-out 8.984 None None None XRAY 1.93 0.187 0.23 A 288 262 12 0 0 9 [[457, 716]] 1.0 7k0v Homo sapiens TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7K0VB P15056 449 722 766.0 VQP:801 Type2 Inactive DFGout 12.34 11.701 BBAminus -167.19, -159.19 -104.12, 109.97 -117.14, 1.82 293.72, 96.78 -102.83, -58.49 in-in in 8.352 Saltbr-in 2.756 HRD-in -71.48, -47.17 73.94, -6.06 in-out-out SNCioo out-out ActLoopNT-out 14.087 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -97.2, 2.25 APE9-dihe-na 176.29, 177.5 APE8-dihe-out 64.18, 15.92 APE8-rot-in 287.72 APE67-dihe-in -68.76, -19.22 -66.09, -26.1 APE12-dist-out 14.721 APE11-dist-out 16.447 APE10-dist-out 12.441 APE9-dist-out 10.103 None None None XRAY 1.93 0.187 0.23 B 288 264 10 0 0 7 [[457, 716]] 1.0 7k0v Homo sapiens TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7K0VC P15056 448 722 766.0 VQP:801 Type2 Inactive DFGout 12.415 11.312 BBAminus -149.63, -160.06 -140.65, 98.9 -96.4, 9.54 307.52, 103.4 -76.49, 147.45 in-in in 8.558 Saltbr-in 2.727 HRD-in -65.37, -52.41 83.32, -6.12 in-out-out SNCioo out-out ActLoopNT-out 18.181 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -119.69 APE8-dihe-out -98.34, 2.05 APE8-rot-in 283.36 APE67-dihe-in -63.48, -24.0 -64.49, -30.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.091 None None None XRAY 1.93 0.187 0.23 C 288 267 8 0 0 8 [[457, 716]] 1.0 7k0v Homo sapiens TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7K0VD P15056 449 722 766.0 VQP:801 Type2 Inactive DFGout 12.377 11.418 BBAminus -149.15, -161.3 -137.52, 97.73 -97.03, 6.48 305.14, 104.21 -74.28, 146.89 in-in in 8.685 Saltbr-in 2.725 HRD-in -66.71, -47.33 78.8, -19.85 in-out-out SNCioo out-out ActLoopNT-out 18.689 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -56.48, -29.5 APE9-dihe-na -75.21, -5.78 APE8-dihe-out -116.03, -0.39 APE8-rot-in 294.97 APE67-dihe-in -63.2, -20.28 -68.0, -40.36 APE12-dist-in 10.95 APE11-dist-in 12.547 APE10-dist-out 13.523 APE9-dist-out 10.751 None None None XRAY 1.93 0.187 0.23 D 288 271 3 0 0 3 [[457, 716]] 1.0 7k0v Homo sapiens TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6P3DA P15056 448 721 766.0 0LI:61001 Type2 Inactive DFGout 12.35 10.905 BBAminus -138.54, -166.92 -135.05, 80.45 -80.66, -37.84 293.17, 97.28 81.0, 10.25 in-in in 8.665 Saltbr-in 2.997 HRD-in -65.6, -55.77 77.59, -19.55 in-out-out SNCioo out-out ActLoopNT-out 19.945 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -19.82 APE9-dihe-na 76.62, -63.3 APE8-dihe-out -51.89, -23.77 APE8-rot-out 78.9 APE67-dihe-in -55.73, -23.59 -56.01, -24.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.7 APE9-dist-out 11.871 None None None XRAY 2.11 0.188 0.245 A 297 261 13 0 0 13 [[457, 716]] 1.0 6p3d Homo sapiens TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6P7GA P15056 449 720 766.0 E7M:801 Type2 Inactive DFGout 12.215 11.891 BBAminus -159.65, -164.2 -127.7, 90.3 -82.38, -7.57 301.17, 86.83 60.88, -78.71 in-in in 8.177 Saltbr-in 2.532 HRD-in -63.47, -53.15 82.99, -13.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -135.97 APE9-dihe-na 134.09, -59.01 APE8-dihe-out -67.41, -14.79 APE8-rot-in 305.65 APE67-dihe-in -66.79, -30.61 -54.99, -26.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.479 APE9-dist-out 10.957 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.65 0.249 0.279 A 297 256 16 0 0 16 [[457, 716]] 1.0 6p7g Homo sapiens TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6P7GC P15056 449 721 766.0 E7M:1001 Type2 Inactive DFGout 12.085 11.902 BBAminus -160.21, -162.76 -128.55, 89.81 -81.26, -8.23 299.73, 85.89 54.67, -101.58 in-in in 8.142 Saltbr-in 2.537 HRD-in -62.98, -54.21 81.98, -13.39 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 56.12 APE8-dihe-out -61.58, -13.4 APE8-rot-in 306.31 APE67-dihe-in -67.6, -30.05 -49.64, -29.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.895 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.65 0.249 0.279 C 297 256 17 0 0 17 [[457, 716]] 1.0 6p7g Homo sapiens TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6P7GD P15056 449 721 766.0 E7M:801 Type2 Inactive DFGout 12.087 11.766 BBAminus -164.2, -158.89 -130.34, 90.23 -82.14, -3.98 300.53, 97.34 65.59, -81.4 in-in in 8.324 Saltbr-in 2.527 HRD-in -63.14, -53.82 83.11, -14.53 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 64.01 APE9-dihe-na -163.55, 2.06 APE8-dihe-out -71.33, -6.98 APE8-rot-in 296.6 APE67-dihe-in -66.21, -30.46 -50.72, -28.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.342 APE9-dist-out 11.097 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.65 0.249 0.279 D 297 254 19 0 0 16 [[457, 716]] 1.0 6p7g Homo sapiens TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 8F7OA P15056 449 723 766.0 QOP:801 Type2 Inactive DFGout 12.249 12.005 BBAminus -159.37, -168.95 -123.81, 84.53 -83.54, -89.81 307.46, 148.61 127.38, -72.17 in-in in 8.972 Saltbr-in 2.449 HRD-in -72.55, -36.43 67.7, -16.13 in-out-out SNCioo out-out ActLoopNT-out 20.564 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na 65.25, -64.98 APE9-dihe-na -63.4, 3.38 APE8-dihe-out -60.69, 15.08 APE8-rot-out 16.0 APE67-dihe-in -61.67, -17.82 -103.11, -29.37 APE12-dist-in 11.837 APE11-dist-in 9.427 APE10-dist-out 14.448 APE9-dist-out 13.325 None None None XRAY 3.54 0.221 0.269 A 283 263 12 0 0 12 [[457, 716]] 1.0 8f7o Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 8F7OB P15056 449 722 766.0 QOP:801 Type2 Inactive DFGout 12.526 11.094 BBAminus -157.64, -171.1 -125.72, 86.17 -82.43, 36.51 307.61, 97.24 -67.66, 176.06 in-in in 8.823 Saltbr-in 2.519 HRD-in -71.26, -35.39 67.81, -16.97 in-out-out SNCioo out-out ActLoopNT-out 13.331 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -143.78, -76.44 APE9-dihe-na -71.8, -5.6 APE8-dihe-out -117.21, 21.56 APE8-rot-in 305.57 APE67-dihe-in -66.7, -20.49 -89.8, -34.59 APE12-dist-out 21.596 APE11-dist-out 24.172 APE10-dist-out 26.848 APE9-dist-out 27.611 None None None XRAY 3.54 0.221 0.269 B 283 263 11 0 0 11 [[457, 716]] 1.0 8f7o Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 8F7PA P15056 449 721 766.0 K81:801 Type2 Inactive DFGout 12.271 11.628 BBAminus -156.68, -164.15 -121.75, 85.43 -84.12, 10.71 303.7, 107.46 -81.06, 134.26 in-in in 8.888 Saltbr-in 3.014 HRD-in -73.5, -44.32 71.2, -9.26 in-out-out SNCioo out-out ActLoopNT-out 18.561 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 33.99 APE8-dihe-out -134.95, 21.55 APE8-rot-in 320.31 APE67-dihe-in -64.87, -22.48 -65.57, -35.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.619 None None None XRAY 2.74 0.216 0.258 A 283 255 18 0 0 14 [[457, 716]] 1.0 8f7p Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 8F7PB P15056 448 721 766.0 K81:801 Type2 Inactive DFGout 12.607 12.007 BBAminus -155.49, -166.94 -122.97, 87.7 -80.57, 10.81 303.23, 78.54 -77.37, 131.38 in-in in 8.787 Saltbr-in 2.438 HRD-in -71.72, -41.08 70.64, -13.43 in-out-out SNCioo out-out ActLoopNT-out 16.028 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -51.39, -20.78 APE9-dihe-na -101.13, 28.63 APE8-dihe-out -146.13, 10.57 APE8-rot-in 318.08 APE67-dihe-in -64.57, -22.2 -69.36, -34.46 APE12-dist-none 999.0 APE11-dist-in 13.018 APE10-dist-out 13.824 APE9-dist-out 10.776 None None None XRAY 2.74 0.216 0.258 B 283 265 9 0 0 6 [[457, 716]] 1.0 8f7p Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4JVGA P15056 448 722 766.0 B96:801 Type2 Inactive DFGout 12.601 12.142 BBAminus -152.0, -179.18 -108.57, 103.11 -89.17, -11.63 297.68, 64.75 -65.51, 135.76 in-in in 8.092 Saltbr-in 2.208 HRD-in -60.98, -42.98 82.63, -9.91 in-out-none SNCion out-none ActLoopNT-out 12.896 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.14 APE8-rot-in 256.63 APE67-dihe-inflip 91.68, -19.72 -68.13, 164.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.09 0.235 0.295 A 284 262 13 0 0 13 [[457, 716]] 1.0 4jvg Homo sapiens TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4JVGB P15056 448 722 766.0 B96:801 Type2 Inactive DFGout 12.826 12.184 BBAminus -174.75, 179.41 -102.42, 106.41 -90.9, -4.12 297.49, 49.02 -65.8, 122.16 in-in in 8.459 Saltbr-in 2.71 HRD-in -64.11, -47.16 78.18, -4.98 in-out-out SNCioo out-out ActLoopNT-out 13.769 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -160.08 APE8-rot-out 74.04 APE67-dihe-in -54.93, -35.08 -66.58, -46.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.09 0.235 0.295 B 284 259 16 0 0 16 [[457, 716]] 1.0 4jvg Homo sapiens TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4JVGC P15056 448 722 766.0 B96:801 Type2 Inactive DFGout 12.873 11.926 BBAminus -170.55, 179.85 -107.23, 105.54 -90.8, -7.34 293.44, 58.77 -62.12, 118.99 in-in in 8.075 Saltbr-in 3.185 HRD-in -64.29, -46.36 80.05, -5.68 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 172.84 APE8-rot-in 258.15 APE67-dihe-in -55.16, -37.17 -69.96, -40.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.09 0.235 0.295 C 284 258 17 0 0 17 [[457, 716]] 1.0 4jvg Homo sapiens TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4JVGD P15056 448 722 766.0 B96:801 Type2 Inactive DFGout 12.516 12.022 BBAminus -150.99, -178.96 -114.25, 104.97 -92.99, -5.76 302.31, 60.74 -58.21, 124.26 in-in in 7.708 Saltbr-in 2.985 HRD-in -62.82, -47.42 78.22, -6.34 in-out-none SNCion out-none ActLoopNT-out 12.749 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 171.09 APE8-rot-in 273.64 APE67-dihe-in -55.99, -27.69 -64.17, -43.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.09 0.235 0.295 D 284 262 13 0 0 13 [[457, 716]] 1.0 4jvg Homo sapiens TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6CADA P15056 449 722 766.0 EU4:801 Type2 Inactive DFGout 12.595 11.825 BBAminus -159.24, -179.7 -103.39, 71.59 -75.73, 54.56 304.33, 87.02 -141.23, 999.0 in-in in 8.568 Saltbr-in 2.974 HRD-out -95.68, 91.01 -62.19, -31.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, -44.86 APE9-dihe-na -72.4, -11.01 APE8-dihe-out -124.58, 43.91 APE8-rot-out 63.2 APE67-dihe-in -54.15, -31.66 -63.78, -40.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.376 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.55 0.256 0.277 A 284 249 25 0 0 17 [[457, 716]] 1.0 6cad Homo sapiens TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6NSQA P15056 448 722 766.0 KZP:801 Type2 Inactive DFGout 12.902 11.243 BBAminus -166.96, 168.99 -96.91, 86.85 -86.08, -39.02 294.09, 94.9 -83.04, -178.29 in-in in 8.909 Saltbr-in 2.678 HRD-out -92.47, 101.24 -82.61, 157.61 in-out-out SNCioo out-out ActLoopNT-out 14.412 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -67.92, -25.45 APE9-dihe-na -63.86, -33.25 APE8-dihe-out -82.75, 8.97 APE8-rot-out 73.84 APE67-dihe-in -57.79, -36.09 -62.1, -28.45 APE12-dist-out 4.008 APE11-dist-out 6.369 APE10-dist-out 10.097 APE9-dist-out 12.107 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.05 0.237 0.275 A 284 274 1 0 0 1 [[457, 716]] 1.0 6nsq Homo sapiens TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 8C7XA P15056 449 721 766.0 TXV:60819 Type2 Inactive DFGout 12.443 11.732 BBAminus -135.27, -175.23 -125.31, 91.5 -84.77, 1.35 298.16, 96.35 -135.3, 38.11 in-in in 8.498 Saltbr-in 2.865 HRD-in -69.83, -48.66 82.13, -14.5 in-out-out SNCioo out-out ActLoopNT-out 14.684 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -57.54, -34.33 APE9-dihe-na -66.65, -4.24 APE8-dihe-out -124.33, -3.25 APE8-rot-in 302.06 APE67-dihe-in -65.06, -18.56 -51.42, -40.3 APE12-dist-in 10.517 APE11-dist-in 10.208 APE10-dist-out 14.036 APE9-dist-out 10.816 None None None XRAY 1.65 0.154 0.171 A 284 273 0 0 0 0 [[457, 716]] 1.0 8c7x Homo sapiens TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 8C7XB P15056 448 721 766.0 TXV:60803 Type2 Inactive DFGout 12.319 11.743 BBAminus -141.6, -169.03 -129.23, 87.73 -87.17, -9.74 297.6, 98.29 46.23, -133.22 in-in in 8.467 Saltbr-in 2.726 HRD-in -71.23, -49.45 77.51, -13.46 in-out-out SNCioo out-out ActLoopNT-out 18.117 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -73.7 APE9-dihe-na -64.9, -3.59 APE8-dihe-out -123.65, 0.9 APE8-rot-in 304.25 APE67-dihe-in -68.19, -19.78 -53.41, -37.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.251 APE9-dist-out 10.731 None None None XRAY 1.65 0.154 0.171 B 284 261 13 0 0 13 [[457, 716]] 1.0 8c7x Homo sapiens TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4XV9A P15056 448 705 766.0 1OO:60801 Type2 Inactive DFGout 13.008 11.278 BBAminus -160.05, -146.26 -134.54, 69.07 -82.79, -64.14 300.54, 89.49 60.6, 38.5 out-out out 11.04 Saltbr-out 8.75 HRD-in -67.4, -51.3 81.85, -11.8 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -66.79, -18.46 APE9-dihe-na -86.17, 22.53 APE8-dihe-out -132.0, -0.24 APE8-rot-in 286.92 APE67-dihe-in -67.66, -22.33 -58.08, -40.23 APE12-dist-none 999.0 APE11-dist-in 10.793 APE10-dist-out 13.834 APE9-dist-out 10.834 R443S,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R None None XRAY 2.0 0.206 0.238 A 292 244 14 0 0 14 [[457, 716]] 1.0 4xv9 Homo sapiens TKL_BRAF_HUMAN TKL 5.3e-84 287.8 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5HI2A P15056 449 721 766.0 BAX:801 Type2 Inactive DFGout 12.342 11.652 BBAminus -149.96, -163.11 -123.43, 99.25 -92.3, 0.56 291.37, 69.87 -68.92, 152.82 in-in in 8.093 Saltbr-in 2.759 HRD-in -69.01, -47.24 79.78, -21.21 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 20.66 APE8-rot-in 304.3 APE67-dihe-in -43.41, -33.84 -68.26, -34.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.512 0.191 0.237 A 283 247 21 0 0 18 [[457, 716]] 1.0 5hi2 Homo sapiens TKL_BRAF_HUMAN TKL 2.7e-82 282.3 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5HIDA P15056 449 722 766.0 B1E:801 Type2 Inactive DFGout 12.493 12.017 BBAminus -148.05, -170.32 -131.28, 92.62 -86.53, -2.96 298.53, 92.2 -68.79, 146.98 in-in in 8.492 Saltbr-in 2.766 HRD-in -64.1, -45.87 83.74, -14.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -62.68, -30.19 APE9-dihe-na -87.33, 7.43 APE8-dihe-out -130.88, -13.43 APE8-rot-in 296.58 APE67-dihe-in -61.83, -28.04 -56.1, -37.18 APE12-dist-in 11.153 APE11-dist-in 12.543 APE10-dist-out 13.696 APE9-dist-out 11.15 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.5 0.236 0.279 A 283 257 12 0 0 12 [[457, 716]] 1.0 5hid Homo sapiens TKL_BRAF_HUMAN TKL 2.7e-82 282.3 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5HIDB P15056 449 722 766.0 B1E:801 Type2 Inactive DFGout 12.159 11.835 BBAminus -150.17, -165.44 -136.1, 98.11 -93.2, 7.71 302.03, 95.62 -74.12, 132.04 in-in in 8.403 Saltbr-in 2.744 HRD-in -63.77, -45.74 86.42, -18.86 in-out-out SNCioo out-out ActLoopNT-out 15.47 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -62.79, -30.35 APE9-dihe-na -86.15, 7.38 APE8-dihe-out -132.43, -14.16 APE8-rot-in 296.5 APE67-dihe-in -61.76, -28.27 -56.26, -37.09 APE12-dist-in 11.765 APE11-dist-in 13.042 APE10-dist-out 14.145 APE9-dist-out 11.066 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.5 0.236 0.279 B 283 269 0 0 0 0 [[457, 716]] 1.0 5hid Homo sapiens TKL_BRAF_HUMAN TKL 2.7e-82 282.3 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 1UWJA P15056 448 723 766.0 BAX:61723 Type2 Inactive DFGout 12.472 11.399 BBAminus -166.47, 179.42 -106.43, 75.02 -68.47, 24.79 296.03, 53.21 -94.41, 168.9 in-in in 8.03 Saltbr-in 2.628 HRD-in -71.1, -39.74 67.88, -2.3 in-out-out SNCioo out-out ActLoopNT-out 14.476 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -8.12 APE8-dihe-in -179.1, 96.45 APE8-rot-out 67.95 APE67-dihe-in -46.32, -38.84 -93.37, -26.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.063 V600E None None XRAY 3.5 0.275 0.357 A 276 264 12 0 0 12 [[457, 716]] 1.0 1uwj Homo sapiens TKL_BRAF_HUMAN TKL 7.6e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 1UWJB P15056 448 723 766.0 BAX:61723 Type2 Inactive DFGout 12.471 11.42 BBAminus -165.41, 177.79 -106.4, 76.01 -68.12, 23.11 295.71, 53.18 -92.84, 169.18 in-in in 8.023 Saltbr-in 2.55 HRD-in -72.21, -38.76 66.05, -0.46 in-out-out SNCioo out-out ActLoopNT-out 14.414 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -129.57 APE8-dihe-in -120.6, 126.56 APE8-rot-out 201.87 APE67-dihe-in -46.86, -38.56 -98.38, -30.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.281 V600E None None XRAY 3.5 0.275 0.357 B 276 263 13 0 0 13 [[457, 716]] 1.0 1uwj Homo sapiens TKL_BRAF_HUMAN TKL 7.6e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6N0PA P15056 449 721 766.0 K81:801 Type2 Inactive DFGout 12.214 11.878 BBAminus -150.84, -166.36 -133.26, 90.72 -86.01, 5.11 312.19, 120.29 -83.35, 143.89 in-in in 8.618 Saltbr-in 2.792 HRD-in -60.05, -51.45 77.42, -10.85 in-out-out SNCioo out-out ActLoopNT-out 13.664 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -167.57, 118.61 APE9-dihe-na -72.7, 74.77 APE8-dihe-out -135.49, 20.32 APE8-rot-in 288.2 APE67-dihe-in -64.39, -23.79 -58.12, -33.58 APE12-dist-out 15.29 APE11-dist-in 12.999 APE10-dist-out 9.621 APE9-dist-out 10.504 None None None XRAY 2.37 0.196 0.233 A 273 268 5 0 0 5 [[457, 716]] 1.0 6n0p Homo sapiens TKL_BRAF_HUMAN TKL 7.1e-82 280.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6N0PB P15056 449 721 766.0 K81:801 Type2 Inactive DFGout 12.27 11.601 BBAminus -154.33, -158.54 -140.36, 105.46 -99.62, 9.7 309.45, 119.59 -74.9, 146.92 in-in in 8.476 Saltbr-in 2.793 HRD-in -59.73, -52.44 77.31, -9.83 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 63.33 APE9-dihe-na 137.65, 178.51 APE8-dihe-out 52.67, 41.68 APE8-rot-out 72.23 APE67-dihe-in -63.68, -28.63 -72.48, -21.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.127 APE9-dist-out 9.729 None None None XRAY 2.37 0.196 0.233 B 273 256 17 0 0 15 [[457, 716]] 1.0 6n0p Homo sapiens TKL_BRAF_HUMAN TKL 7.1e-82 280.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 8QQGB P15056 448 721 766.0 WJ9:60801 Type2 Inactive DFGout 12.382 12.017 BBAminus -147.64, -162.97 -128.12, 93.85 -88.61, -11.38 305.49, 128.3 -67.77, 148.99 in-in in 8.343 Saltbr-in 2.945 HRD-in -62.34, -52.73 84.22, -12.03 in-out-out SNCioo out-out ActLoopNT-out 14.174 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -85.62, -151.01 APE9-dihe-na 70.57, -172.47 APE8-dihe-in -97.07, 129.86 APE8-rot-in 279.34 APE67-dihe-in -65.5, -31.27 -104.89, -8.68 APE12-dist-none 999.0 APE11-dist-in 13.739 APE10-dist-out 10.992 APE9-dist-out 9.912 None None None XRAY 2.979 0.225 0.261 B 275 262 12 0 0 12 [[457, 716]] 1.0 8qqg Homo sapiens TKL_BRAF_HUMAN TKL 7.3e-82 280.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 8QQGC P15056 448 721 766.0 WJ9:60801 Type2 Inactive DFGout 12.154 11.896 BBAminus -150.55, -165.27 -126.65, 93.95 -89.32, -7.92 305.19, 129.14 -67.42, 148.67 in-in in 7.878 Saltbr-in 2.934 HRD-in -64.1, -53.0 82.95, -9.08 in-out-out SNCioo out-out ActLoopNT-out 14.73 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -89.43, -34.97 APE9-dihe-na -79.6, -159.5 APE8-dihe-in -94.88, 131.57 APE8-rot-out 206.31 APE67-dihe-in -66.23, -31.33 -106.98, -10.88 APE12-dist-out 17.968 APE11-dist-out 15.914 APE10-dist-out 10.977 APE9-dist-out 8.683 None None None XRAY 2.979 0.225 0.261 C 275 266 8 0 0 6 [[457, 716]] 1.0 8qqg Homo sapiens TKL_BRAF_HUMAN TKL 7.3e-82 280.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5CT7A P15056 449 721 766.0 55J:801 Type2 Inactive DFGout 12.886 11.052 BBAminus -138.5, -161.87 -136.53, 63.32 -70.71, 0.76 307.97, 85.91 -84.3, 147.11 in-in in 7.833 Saltbr-in 2.965 HRD-in -54.99, -43.88 73.11, -9.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 170.28 APE8-dihe-in -118.08, 74.43 APE8-rot-out 47.26 APE67-dihe-in -69.51, -27.98 -64.63, -15.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.883 None None None XRAY 3.17 0.183 0.217 A 281 257 16 0 0 16 [[457, 716]] 1.0 5ct7 Homo sapiens TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5VALA P15056 446 720 766.0 92D:801 Type2 Inactive DFGout 12.11 11.911 BBAminus -149.01, -174.68 -126.07, 88.73 -82.22, 0.8 299.36, 118.93 169.17, 999.0 in-in in 8.015 Saltbr-in 2.798 HRD-in -64.34, -52.83 80.65, -12.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 33.61 APE8-rot-out 63.69 APE67-dihe-in -62.38, -27.8 -66.35, -27.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.26 0.183 0.217 A 281 254 21 0 0 19 [[457, 716]] 1.0 5val Homo sapiens TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5VALB P15056 448 721 766.0 92D:801 Type2 Inactive DFGout 12.354 11.993 BBAminus -149.26, -173.77 -126.01, 88.92 -82.78, 0.42 299.72, 118.18 52.97, -120.88 in-in in 8.298 Saltbr-in 2.728 HRD-in -64.61, -53.09 81.08, -12.76 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -50.39 APE8-dihe-in -90.0, 76.18 APE8-rot-out 45.23 APE67-dihe-in -62.08, -27.1 -72.62, -25.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.213 None None None XRAY 2.26 0.183 0.217 B 281 254 20 0 0 17 [[457, 716]] 1.0 5val Homo sapiens TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5VAMA P15056 449 721 766.0 92J:801 Type2 Inactive DFGout 12.357 11.611 BBAminus -140.58, -169.46 -141.4, 105.48 -100.78, 5.91 303.65, 125.69 -66.9, 143.7 in-in in 8.659 Saltbr-in 2.781 HRD-in -61.66, -53.22 75.75, -7.37 in-out-out SNCioo out-out ActLoopNT-out 16.385 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -116.11, 170.97 APE9-dihe-na 75.01, 10.89 APE8-dihe-out -136.21, 30.89 APE8-rot-in 310.43 APE67-dihe-in -62.28, -24.09 -56.43, -35.95 APE12-dist-out 17.014 APE11-dist-in 12.06 APE10-dist-out 12.944 APE9-dist-out 9.767 None None None XRAY 2.1 0.194 0.223 A 281 269 4 0 0 4 [[457, 716]] 1.0 5vam Homo sapiens TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5VAMB P15056 449 721 766.0 92J:801 Type2 Inactive DFGout 12.148 11.53 BBAminus -153.03, -162.76 -138.62, 102.37 -98.12, 14.9 310.11, 121.47 -69.82, 134.27 in-in in 9.125 Saltbr-in 2.782 HRD-in -61.72, -53.8 75.79, -5.73 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 117.24 APE8-dihe-in -95.34, 81.39 APE8-rot-in 346.58 APE67-dihe-in -66.96, -30.47 -72.22, -17.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.178 None None None XRAY 2.1 0.194 0.223 B 281 260 13 0 0 13 [[457, 716]] 1.0 5vam Homo sapiens TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6B8UA P15056 449 720 766.0 8EN:801 Type2 Inactive DFGout 12.512 11.898 BBAminus -161.83, -162.08 -129.43, 94.63 -82.19, -3.04 296.13, 79.0 -80.39, 164.52 in-in in 8.689 Saltbr-in 2.829 HRD-in -58.24, -54.19 79.37, -7.03 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -156.99 APE8-dihe-in -124.8, 88.68 APE8-rot-out 60.47 APE67-dihe-in -67.38, -25.35 -78.09, -12.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.404 None None None XRAY 2.68 0.18 0.218 A 281 253 19 0 0 16 [[457, 716]] 1.0 6b8u Homo sapiens TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6B8UB P15056 447 720 766.0 8EN:801 Type2 Inactive DFGout 12.531 12.284 BBAminus -160.02, -169.59 -125.27, 94.83 -82.88, 12.14 291.51, 88.01 57.91, 999.0 in-in in 8.375 Saltbr-in 2.77 HRD-in -59.3, -53.28 79.2, -6.72 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -20.81 APE8-rot-in 292.76 APE67-dihe-in -67.06, -25.25 -64.08, -25.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.68 0.18 0.218 B 281 248 26 0 0 19 [[457, 716]] 1.0 6b8u Homo sapiens TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6N0QA P15056 446 721 766.0 K7S:801 Type2 Inactive DFGout 12.152 11.976 BBAminus -145.97, -168.83 -131.27, 90.27 -81.9, -25.38 302.79, 126.64 -85.46, 999.0 in-in in 8.219 Saltbr-in 2.76 HRD-in -66.82, -47.88 78.99, -14.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 105.38 APE9-dihe-na -87.38, 57.4 APE8-dihe-out -149.43, 0.41 APE8-rot-out 65.63 APE67-dihe-in -63.4, -24.61 -63.61, -33.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.794 None None None XRAY 2.04 0.182 0.213 A 281 257 19 0 0 17 [[457, 716]] 1.0 6n0q Homo sapiens TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6N0QB P15056 448 721 766.0 K7S:801 Type2 Inactive DFGout 12.234 12.096 BBAminus -154.72, -168.56 -126.78, 88.07 -81.57, 1.49 304.84, 119.23 48.5, -147.29 in-in in 8.377 Saltbr-in 2.743 HRD-in -68.08, -48.45 77.62, -16.78 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -71.71 APE8-dihe-in -79.85, 72.37 APE8-rot-out 48.17 APE67-dihe-in -65.78, -27.35 -71.67, -17.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.42 None None None XRAY 2.04 0.182 0.213 B 281 254 20 0 0 17 [[457, 716]] 1.0 6n0q Homo sapiens TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3Q96A P15056 449 722 766.0 0NF:1 Type2 Inactive DFGout 12.887 10.676 BBAminus -160.13, -172.44 -118.2, 91.86 -79.01, 12.35 294.04, 84.62 -59.8, 141.31 in-in in 8.392 Saltbr-in 2.855 HRD-in -57.31, -47.78 82.12, -11.82 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -115.71 APE8-rot-in 265.02 APE67-dihe-in -61.58, -24.04 -87.09, -36.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.233 0.288 A 282 253 21 0 0 18 [[457, 716]] 1.0 3q96 Homo sapiens TKL_BRAF_HUMAN TKL 8e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3Q96B P15056 449 720 766.0 0NF:1 Type2 Inactive DFGout 12.338 11.655 BBAminus -159.06, -168.23 -117.43, 81.54 -79.68, 17.57 296.0, 82.29 -26.83, 105.54 in-in in 8.586 Saltbr-in 3.176 HRD-in -76.92, -42.58 73.28, -12.97 in-out-out SNCioo out-out ActLoopNT-out 18.49 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 159.44 APE8-dihe-in -92.55, 126.53 APE8-rot-in 290.06 APE67-dihe-in -62.77, -20.3 -102.35, -28.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.232 None None None XRAY 3.1 0.233 0.288 B 282 262 10 0 0 10 [[457, 716]] 1.0 3q96 Homo sapiens TKL_BRAF_HUMAN TKL 8e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4DBNA P15056 448 721 766.0 0JA:60901 Type2 Inactive DFGout 12.524 11.592 BBAminus -154.44, -162.66 -150.64, 90.45 -97.41, 13.96 314.34, 97.82 -74.51, 142.3 in-in in 8.345 Saltbr-in 2.831 HRD-in -68.35, -47.82 78.16, -4.01 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 178.62 APE8-dihe-in -127.19, 92.91 APE8-rot-out 54.29 APE67-dihe-in -55.76, -28.27 -65.45, -34.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.512 None None None XRAY 3.15 0.198 0.243 A 284 257 17 0 0 17 [[457, 716]] 1.0 4dbn Homo sapiens TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4DBNB P15056 448 720 766.0 0JA:60901 Type2 Inactive DFGout 12.609 11.59 BBAminus -128.03, -174.95 -129.84, 81.69 -87.83, -34.52 305.83, 115.71 70.01, -76.13 in-in in 8.216 Saltbr-in 2.902 HRD-in -63.73, -52.28 81.42, -15.1 in-out-out SNCioo out-out ActLoopNT-out 18.344 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -154.96 APE8-dihe-in -121.29, 96.58 APE8-rot-out 211.52 APE67-dihe-in -67.37, -17.59 -73.93, -38.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.298 None None None XRAY 3.15 0.198 0.243 B 284 263 10 0 0 10 [[457, 716]] 1.0 4dbn Homo sapiens TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4FC0A P15056 448 722 766.0 0T2:60901 Type2 Inactive DFGout 12.126 11.586 BBAminus -153.59, -164.38 -132.76, 92.72 -91.26, 26.45 298.08, 84.06 -114.26, 999.0 in-in in 8.796 Saltbr-in 2.697 HRD-in -64.95, -50.81 80.25, -12.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 154.13 APE8-dihe-in -107.59, 65.51 APE8-rot-in 301.84 APE67-dihe-in -60.02, -23.67 -50.91, -43.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.522 None None None XRAY 2.95 0.2 0.243 A 284 254 21 0 0 18 [[457, 716]] 1.0 4fc0 Homo sapiens TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4FC0B P15056 448 720 766.0 0T2:60901 Type2 Inactive DFGout 12.239 11.705 BBAminus -154.95, -168.83 -118.03, 93.75 -95.71, 51.36 301.2, 97.17 -51.2, 96.43 in-in in 8.256 Saltbr-in 2.925 HRD-in -64.51, -53.67 78.65, 1.79 in-out-out SNCioo out-out ActLoopNT-out 18.643 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -114.88 APE8-dihe-in -124.62, 102.83 APE8-rot-in 269.89 APE67-dihe-in -59.25, -18.38 -83.24, -36.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.89 None None None XRAY 2.95 0.2 0.243 B 284 263 10 0 0 10 [[457, 716]] 1.0 4fc0 Homo sapiens TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4KSPA P15056 448 722 766.0 1SU:60901 Type2 Inactive DFGout 12.838 11.375 BBAminus -149.86, -149.06 -154.88, 90.05 -92.69, 5.43 311.76, 133.96 -47.03, 999.0 in-in in 8.4 Saltbr-in 2.992 HRD-in -71.91, -41.9 72.24, -17.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 169.52 APE8-dihe-in -109.46, 89.69 APE8-rot-in 258.16 APE67-dihe-in -65.67, -26.43 -74.75, -36.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.845 None None None XRAY 2.93 0.197 0.242 A 284 257 18 0 0 18 [[457, 716]] 1.0 4ksp Homo sapiens TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4KSPB P15056 448 720 766.0 1SU:60901 Type2 Inactive DFGout 12.257 11.846 BBAminus -174.12, -155.73 -118.56, 108.74 -113.95, 66.59 308.83, 114.94 -51.82, -77.14 in-out in 8.44 Saltbr-out 3.88 HRD-in -64.99, -50.42 81.78, -18.05 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.14 APE8-dihe-in -120.79, 103.17 APE8-rot-in 280.31 APE67-dihe-in -69.23, -21.09 -88.21, -30.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.148 None None None XRAY 2.93 0.197 0.242 B 284 256 17 0 0 17 [[457, 716]] 1.0 4ksp Homo sapiens TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4KSQA P15056 448 722 766.0 1SW:60901 Type2 Inactive DFGout 12.7 11.263 BBAminus -139.07, -156.01 -144.98, 102.81 -100.72, 21.0 314.74, 133.71 -88.35, 145.76 in-in in 8.372 Saltbr-in 2.877 HRD-in -64.0, -43.15 74.68, -17.09 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 177.23 APE8-dihe-in -108.75, 103.33 APE8-rot-out 22.61 APE67-dihe-in -67.5, -19.5 -79.7, -29.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 7.836 None None None XRAY 3.3 0.208 0.256 A 284 258 17 0 0 17 [[457, 716]] 1.0 4ksq Homo sapiens TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4KSQB P15056 449 720 766.0 1SW:60901 Type2 Inactive DFGout 12.08 11.493 BBAminus -150.55, -156.53 -118.96, 105.53 -118.02, 18.97 306.08, 127.85 -60.37, 126.34 in-in in 8.332 Saltbr-in 2.809 HRD-in -72.57, -35.68 69.22, 0.73 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -48.23 APE8-dihe-in -139.11, 75.84 APE8-rot-in 282.78 APE67-dihe-in -67.26, -25.58 -86.58, -18.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.927 None None None XRAY 3.3 0.208 0.256 B 284 255 17 0 0 17 [[457, 716]] 1.0 4ksq Homo sapiens TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3IDPA P15056 449 720 766.0 L1E:2 Type2 Inactive DFGout 12.784 11.643 BBAminus -154.3, -166.43 -118.1, 93.34 -83.15, -5.46 288.88, 80.78 -65.67, 144.09 in-in in 8.476 Saltbr-in 2.797 HRD-in -56.89, -51.61 76.63, -12.91 in-out-out SNCioo out-out ActLoopNT-out 13.943 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -130.04 APE8-dihe-in -103.78, 110.36 APE8-rot-in 306.9 APE67-dihe-in -67.72, -24.2 -82.73, -11.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.893 V600E None None XRAY 2.7 0.206 0.264 A 300 255 17 0 0 15 [[457, 716]] 1.0 3idp Homo sapiens TKL_BRAF_HUMAN TKL 1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3IDPB P15056 449 720 766.0 L1E:1 Type2 Inactive DFGout 12.66 12.065 BBAminus -170.28, -168.48 -119.7, 97.43 -90.31, 6.48 291.12, 88.12 -97.93, 157.06 in-in in 8.02 Saltbr-in 2.77 HRD-in -64.31, -45.74 77.59, -13.7 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 27.56 APE9-dihe-na -92.87, 13.62 APE8-dihe-out -117.99, 16.22 APE8-rot-out 50.32 APE67-dihe-in -55.44, -27.24 -54.86, -44.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.914 APE9-dist-out 10.591 V600E None None XRAY 2.7 0.206 0.264 B 300 256 16 0 0 16 [[457, 716]] 1.0 3idp Homo sapiens TKL_BRAF_HUMAN TKL 1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4G9RA P15056 448 721 766.0 B1E:801 Type2 Inactive DFGout 12.281 11.51 BBAminus -140.44, -166.78 -124.54, 91.04 -84.58, 2.38 307.85, 108.16 -62.63, 139.55 in-in in 8.807 Saltbr-in 3.043 HRD-in -67.08, -45.9 76.5, -11.17 in-out-out SNCioo out-out ActLoopNT-out 13.601 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 154.29 APE8-dihe-in -88.42, 102.32 APE8-rot-out 32.85 APE67-dihe-in -68.06, -31.95 -78.15, -27.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.034 V600E None None XRAY 3.2 0.229 0.277 A 307 262 12 0 0 12 [[457, 716]] 1.0 4g9r Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.2 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5C9CA P15056 449 720 766.0 4Z5:60900 Type2 Inactive DFGout 12.175 11.99 BBAminus -152.77, -152.03 -130.27, 99.34 -91.23, 12.84 306.39, 96.61 -100.31, 162.73 in-in in 8.656 Saltbr-in 2.707 HRD-in -65.42, -47.95 80.81, -8.16 in-out-out SNCioo out-out ActLoopNT-out 14.134 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 42.04 APE8-rot-out 210.25 APE67-dihe-in -65.15, -19.42 -79.84, -17.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 V600E None None XRAY 2.7 0.196 0.238 A 307 254 18 0 0 16 [[457, 716]] 1.0 5c9c Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.2 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5C9CB P15056 449 720 766.0 4Z5:60801 Type2 Inactive DFGout 12.2 12.241 BBAminus -164.91, -156.21 -132.52, 106.2 -105.64, 12.12 297.13, 98.22 -118.65, 173.79 in-in in 8.611 Saltbr-in 2.75 HRD-in -71.76, -43.74 73.35, -12.16 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 165.69 APE8-rot-in 273.18 APE67-dihe-in -53.48, -28.51 -70.47, -29.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 V600E None None XRAY 2.7 0.196 0.238 B 307 251 21 0 0 18 [[457, 716]] 1.0 5c9c Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.2 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 1UWHA P15056 448 723 766.0 BAX:61723 Type2 Inactive DFGout 12.495 11.481 BBAminus -173.91, -166.78 -121.32, 89.16 -83.23, 16.41 301.34, 66.03 -83.78, 148.03 in-in in 8.456 Saltbr-in 2.989 HRD-in -65.62, -55.23 80.22, -7.91 in-out-out SNCioo out-out ActLoopNT-out 14.57 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -61.57, 175.06 APE9-dihe-na 174.29, 130.89 APE8-dihe-in -93.46, 78.64 APE8-rot-out 46.11 APE67-dihe-in -63.44, -27.03 -60.72, -32.82 APE12-dist-none 999.0 APE11-dist-in 11.595 APE10-dist-out 8.374 APE9-dist-out 8.656 None None None XRAY 2.95 0.222 0.257 A 276 264 12 0 0 12 [[457, 716]] 1.0 1uwh Homo sapiens TKL_BRAF_HUMAN TKL 1.8e-81 279.5 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 1UWHB P15056 448 723 766.0 BAX:61723 Type2 Inactive DFGout 12.495 11.491 BBAminus -173.56, -167.09 -121.29, 88.77 -83.17, 16.44 301.44, 65.99 -83.54, 148.34 in-in in 8.438 Saltbr-in 2.963 HRD-in -65.94, -55.1 80.05, -8.58 in-out-out SNCioo out-out ActLoopNT-out 14.988 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioo APE10-dihe-na -54.44, 165.53 APE9-dihe-na -176.68, 134.04 APE8-dihe-in -91.08, 81.56 APE8-rot-out 44.97 APE67-dihe-in -53.91, -27.06 -61.59, -40.98 APE12-dist-none 999.0 APE11-dist-in 11.198 APE10-dist-out 8.711 APE9-dist-out 9.032 None None None XRAY 2.95 0.222 0.257 B 276 264 12 0 0 12 [[457, 716]] 1.0 1uwh Homo sapiens TKL_BRAF_HUMAN TKL 1.8e-81 279.5 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3II5A P15056 448 720 766.0 831:60001 Type2 Inactive DFGout 12.301 11.496 BBAminus -155.57, -166.63 -127.64, 99.56 -98.31, 13.93 306.98, 120.6 -79.68, 131.63 in-in in 9.106 Saltbr-in 3.018 HRD-in -60.69, -56.02 84.38, -6.21 in-out-out SNCioo out-out ActLoopNT-out 13.961 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -120.26, -83.23 APE9-dihe-na 113.98, 136.9 APE8-dihe-in -101.61, 115.55 APE8-rot-out 202.45 APE67-dihe-in -63.73, -30.08 -83.87, -5.58 APE12-dist-in 13.239 APE11-dist-in 8.684 APE10-dist-out 10.766 APE9-dist-out 7.853 None None None XRAY 2.79 0.209 0.251 A 306 262 11 0 0 11 [[457, 716]] 1.0 3ii5 Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3II5B P15056 449 721 766.0 831:60001 Type2 Inactive DFGout 12.443 11.441 BBAminus -134.74, -174.76 -130.73, 93.7 -95.95, 18.9 313.23, 121.08 -68.68, 112.3 in-in in 8.876 Saltbr-in 2.72 HRD-in -72.77, -40.04 68.53, -1.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -10.56 APE8-dihe-in -115.75, 77.93 APE8-rot-in 273.36 APE67-dihe-in -56.24, -18.59 -62.57, -41.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.731 None None None XRAY 2.79 0.209 0.251 B 306 257 16 0 0 16 [[457, 716]] 1.0 3ii5 Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4G9CA P15056 448 723 766.0 0WP:801 Type2 Inactive DFGout 12.323 11.957 BBAminus -161.79, -178.1 -114.62, 68.22 -59.97, -23.71 305.31, 100.52 75.79, -130.3 in-in in 8.462 Saltbr-in 2.898 HRD-in -82.65, -45.05 76.52, 0.21 in-out-out SNCioo out-out ActLoopNT-out 18.943 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -63.56, -116.68 APE9-dihe-na 141.17, 171.61 APE8-dihe-in -108.81, 106.37 APE8-rot-in 322.97 APE67-dihe-in -54.58, -37.58 -76.8, -42.56 APE12-dist-none 999.0 APE11-dist-out 14.198 APE10-dist-out 11.022 APE9-dist-out 8.852 None None None XRAY 3.5 0.262 0.291 A 307 265 11 0 0 11 [[457, 716]] 1.0 4g9c Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4G9CB P15056 448 723 766.0 0WP:801 Type2 Inactive DFGout 12.372 11.675 BBAminus -162.63, -177.84 -114.09, 70.68 -59.01, -42.42 300.41, 107.75 -27.19, 128.65 in-in in 8.505 Saltbr-in 2.914 HRD-in -80.74, -47.08 78.89, -0.43 in-out-out SNCioo out-out ActLoopNT-out 16.551 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -65.14, -116.41 APE9-dihe-na 140.87, 171.82 APE8-dihe-in -109.02, 105.11 APE8-rot-in 323.76 APE67-dihe-in -55.25, -37.4 -76.81, -41.18 APE12-dist-none 999.0 APE11-dist-in 13.621 APE10-dist-out 11.737 APE9-dist-out 8.869 None None None XRAY 3.5 0.262 0.291 B 307 264 12 0 0 12 [[457, 716]] 1.0 4g9c Homo sapiens TKL_BRAF_HUMAN TKL 1.1e-81 280.3 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6P7GB P15056 449 721 766.0 E7M:801,NHE:802 Type2,Allosteric Inactive DFGout 12.213 11.607 BBAminus -161.83, -162.67 -128.78, 90.51 -86.35, -51.52 303.99, 97.12 26.26, 73.75 in-in in 8.25 Saltbr-in 2.536 HRD-in -62.65, -53.67 83.64, -15.67 in-out-out SNCioo out-out ActLoopNT-out 21.235 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -80.82, -17.55 APE9-dihe-na -132.56, -84.95 APE8-dihe-out -42.28, -25.63 APE8-rot-in 319.56 APE67-dihe-in -73.22, -25.37 -56.64, -24.48 APE12-dist-in 12.581 APE11-dist-out 14.229 APE10-dist-out 10.095 APE9-dist-out 10.776 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.65 0.249 0.279 B 297 273 0 0 0 0 [[457, 716]] 1.0 6p7g Homo sapiens TKL_BRAF_HUMAN TKL 5.8e-84 287.7 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4RZWA P15056 448 720 766.0 B1E:801 Type1 Inactive DFGout 12.982 11.639 None -156.36, -171.72 -123.23, 113.58 -116.17, 177.63 318.28, 100.74 -121.26, 999.0 in-in in 8.374 Saltbr-in 2.791 HRD-in -73.4, -48.32 68.37, -5.73 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 16.65 APE8-dihe-in -104.01, 112.39 APE8-rot-in 337.69 APE67-dihe-in -68.56, -25.59 -122.97, -37.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.887 R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.493 0.248 0.28 A 281 251 22 0 0 18 [[457, 716]] 1.0 4rzw Homo sapiens TKL_BRAF_HUMAN TKL 7.2e-84 287.4 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 3C4CB P15056 448 721 766.0 324:60003 Type1.5_Back Inactive DFGout 17.121 11.474 None -158.07, 167.38 -86.45, 172.73 27.7, 999.0 226.78, 93.67 999.0, 999.0 in-out in 9.671 Saltbr-out 7.076 HRD-in -64.15, -34.82 70.63, -1.96 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 56.1 APE9-dihe-na 175.12, 83.72 APE8-dihe-in -104.65, 152.29 APE8-rot-in 256.49 APE67-dihe-in -58.95, -27.9 -70.54, -27.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.729 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 2.57 0.261 0.303 B 280 256 18 0 0 18 [[457, 716]] 1.0 3c4c Homo sapiens TKL_BRAF_HUMAN TKL 4.5e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4RZWB P15056 448 721 766.0 B1E:801 Type2 Inactive DFGout 12.777 11.345 None -156.46, -173.05 -125.91, 116.19 -115.01, 999.0 318.43, 102.28 999.0, 999.0 in-in in 8.698 Saltbr-in 2.594 HRD-in -72.06, -47.23 69.11, -4.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 173.84 APE8-dihe-in -101.6, 117.12 APE8-rot-in 296.77 APE67-dihe-in -61.72, -26.32 -116.4, -11.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.268 R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.493 0.248 0.28 B 281 252 22 0 0 19 [[457, 716]] 1.0 4rzw Homo sapiens TKL_BRAF_HUMAN TKL 7.2e-84 287.4 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6CADB P15056 449 721 766.0 EU4:801 Type2 Inactive DFGout 12.662 12.132 None -160.15, -178.54 -102.61, 71.13 -75.43, 999.0 305.36, 107.93 999.0, 999.0 in-in in 9.177 Saltbr-in 2.868 HRD-out -93.08, 91.91 -61.44, -31.11 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, -45.98 APE9-dihe-na 97.43, -17.05 APE8-dihe-out -130.37, 38.81 APE8-rot-out 60.99 APE67-dihe-in -57.79, -30.41 -66.2, -46.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.938 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.55 0.256 0.277 B 284 248 25 0 0 18 [[457, 716]] 1.0 6cad Homo sapiens TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6NSQB P15056 447 722 766.0 KZP:801 Type2 Inactive DFGout 12.875 11.101 None -166.73, 169.09 -97.13, 87.27 -86.05, 168.9 293.43, 85.03 -83.41, 999.0 in-in in 9.027 Saltbr-in 2.429 HRD-out -91.78, 102.77 -82.81, 156.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -34.39 APE8-dihe-out -84.15, 8.29 APE8-rot-out 179.63 APE67-dihe-in -56.54, -36.36 -64.17, -26.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.775 I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 3.05 0.237 0.275 B 284 253 23 0 0 18 [[457, 716]] 1.0 6nsq Homo sapiens TKL_BRAF_HUMAN TKL 4.8e-84 288.0 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 8QQGA P15056 449 722 766.0 WJ9:60801 Type2 Inactive DFGout 12.472 11.969 None -151.57, -162.48 -133.16, 90.66 -89.77, 999.0 301.2, 128.17 999.0, 999.0 in-in in 8.016 Saltbr-in 2.939 HRD-in -63.61, -53.7 83.78, -13.79 in-out-out SNCioo out-out ActLoopNT-out 19.241 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -92.3, -36.41 APE9-dihe-na -80.62, -156.71 APE8-dihe-in -88.56, 123.78 APE8-rot-in 289.2 APE67-dihe-in -66.04, -32.02 -104.4, -18.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.105 None None None XRAY 2.979 0.225 0.261 A 275 269 5 0 0 3 [[457, 716]] 1.0 8qqg Homo sapiens TKL_BRAF_HUMAN TKL 7.3e-82 280.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 5CT7B P15056 449 721 766.0 55J:801 Type2 Inactive DFGout 13.038 11.219 None -137.4, -162.96 -136.57, 63.11 -71.61, 999.0 306.68, 86.17 999.0, 999.0 in-in in 7.777 Saltbr-in 2.976 HRD-in -56.61, -40.43 63.81, 0.34 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 168.65 APE8-dihe-in -118.54, 73.49 APE8-rot-out 48.75 APE67-dihe-in -70.66, -26.63 -65.01, -15.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.198 None None None XRAY 3.17 0.183 0.217 B 281 254 19 0 0 19 [[457, 716]] 1.0 5ct7 Homo sapiens TKL_BRAF_HUMAN TKL 7.9e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 8VYPC P15056 363 733 766.0 AGS:801 ATPlike Inactive None 999.0 999.0 None 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 8.998 Saltbr-out 6.594 HRD-in -95.64, -57.28 53.13, 41.02 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 V600E SEP365,SEP729 SEP365,SEP729 EM 3.29 999.0 999.0 C 767 171 110 0 0 30 [[457, 716]] 1.0 8vyp Homo sapiens TKL_BRAF_HUMAN TKL 1.3e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 8VYRA P15056 361 736 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-none in 8.202 Saltbr-none 999.0 HRD-in -72.99, -54.08 72.8, -14.1 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -3.13 APE8-rot-none 999.0 APE67-dihe-in -78.78, -23.88 -52.18, -42.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 V600E SEP365,SEP729 SEP365,SEP729 EM 4.32 999.0 999.0 A 767 235 56 0 0 22 [[457, 716]] 1.0 8vyr Homo sapiens TKL_BRAF_HUMAN TKL 1.3e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7ZR0K P15056 521 724 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None -147.96, -165.47 -131.21, -25.27 -43.61, 121.0 28.34, 64.52 -164.96, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -123.64, -31.16 73.6, -12.81 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 152.74 APE8-dihe-out -135.59, 42.49 APE8-rot-out 92.4 APE67-dihe-in -103.42, -12.96 -90.89, 11.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.747 None None None EM 3.4 999.0 999.0 K 828 186 82 0 0 18 [[457, 716]] 1.0 7zr0 Homo sapiens TKL_BRAF_HUMAN TKL 1.5e-80 276.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7ZR5K P15056 521 724 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None -142.68, 170.56 -118.72, -1.17 -61.64, 141.86 74.36, 104.13 -173.91, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.18, -30.56 72.36, -16.41 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 76.96 APE8-dihe-out -138.42, 28.65 APE8-rot-out 67.46 APE67-dihe-in -98.65, -24.43 -90.46, 11.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.779 None None None EM 3.9 999.0 999.0 K 828 186 82 0 0 18 [[457, 716]] 1.0 7zr5 Homo sapiens TKL_BRAF_HUMAN TKL 1.5e-80 276.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 7ZR6K P15056 521 724 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None -98.5, 171.19 -129.29, -36.65 -81.13, 151.47 63.73, 90.42 -79.12, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -116.13, -33.15 67.35, -9.25 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -36.72 APE8-dihe-out -120.28, 26.45 APE8-rot-out 68.06 APE67-dihe-in -122.37, 11.39 -67.64, -22.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.453 None None None EM 4.2 999.0 999.0 K 828 186 82 0 0 18 [[457, 716]] 1.0 7zr6 Homo sapiens TKL_BRAF_HUMAN TKL 1.5e-80 276.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6Q0JA P15056 449 733 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None -125.75, -157.37 46.77, 85.74 -102.95, 25.57 999.0, 999.0 -59.98, -20.53 in-none in 8.812 Saltbr-none 999.0 HRD-in -72.62, -45.55 71.04, -1.27 none-in-out SNCnio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioi APE10-dihe-na -136.58, 156.58 APE9-dihe-na 140.45, 169.19 APE8-dihe-in -83.63, 130.47 APE8-rot-none 999.0 APE67-dihe-in -60.99, -19.46 -69.8, -34.98 APE12-dist-in 12.005 APE11-dist-in 11.471 APE10-dist-out 8.112 APE9-dist-in 5.608 S365A SEP729 SEP729 EM 4.9 999.0 999.0 A 805 281 4 0 0 0 [[457, 716]] 1.0 6q0j Homo sapiens TKL_BRAF_HUMAN TKL 1.4e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6Q0JB P15056 449 734 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None -125.77, -157.3 46.62, 85.83 -103.01, 25.5 999.0, 999.0 -59.84, -20.56 in-none in 8.812 Saltbr-none 999.0 HRD-in -72.72, -45.58 70.9, -1.18 none-in-out SNCnio in-out ActLoopNT-in 2.865 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioi APE10-dihe-na -136.54, 156.42 APE9-dihe-na 140.6, 169.11 APE8-dihe-in -83.47, 130.71 APE8-rot-none 999.0 APE67-dihe-in -60.7, -19.7 -69.93, -35.05 APE12-dist-in 12.006 APE11-dist-in 11.471 APE10-dist-out 8.112 APE9-dist-in 5.607 S365A SEP729 SEP729 EM 4.9 999.0 999.0 B 805 282 4 0 0 0 [[457, 716]] 1.0 6q0j Homo sapiens TKL_BRAF_HUMAN TKL 1.4e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6Q0TA P15056 449 732 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None -125.68, -157.44 46.86, 85.51 -102.96, 25.68 999.0, 999.0 -59.84, -20.53 in-none in 8.812 Saltbr-none 999.0 HRD-in -72.53, -45.64 70.89, -1.18 none-in-out SNCnio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioi APE10-dihe-na -136.48, 156.68 APE9-dihe-na 140.41, 169.16 APE8-dihe-in -83.57, 130.55 APE8-rot-none 999.0 APE67-dihe-in -60.84, -19.83 -69.97, -34.72 APE12-dist-in 12.006 APE11-dist-in 11.472 APE10-dist-out 8.113 APE9-dist-in 5.61 S365A SEP729 SEP729 EM 5.7 999.0 999.0 A 805 280 4 0 0 0 [[457, 716]] 1.0 6q0t Homo sapiens TKL_BRAF_HUMAN TKL 1.4e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6Q0TB P15056 449 730 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None -125.71, -157.51 46.95, 85.47 -102.88, 25.78 999.0, 999.0 -60.15, -20.42 in-none in 8.813 Saltbr-none 999.0 HRD-in -72.6, -45.69 70.98, -1.32 none-in-out SNCnio in-out ActLoopNT-in 2.863 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioi APE10-dihe-na -136.41, 156.62 APE9-dihe-na 140.41, 169.2 APE8-dihe-in -83.59, 130.6 APE8-rot-none 999.0 APE67-dihe-in -60.82, -19.75 -69.88, -34.94 APE12-dist-in 12.003 APE11-dist-in 11.471 APE10-dist-out 8.113 APE9-dist-in 5.609 S365A SEP729 SEP729 EM 5.7 999.0 999.0 B 805 278 4 0 0 0 [[457, 716]] 1.0 6q0t Homo sapiens TKL_BRAF_HUMAN TKL 1.4e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6Q0KA P15056 449 737 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None -125.65, -157.35 46.68, 85.84 -103.11, 25.65 999.0, 999.0 -59.88, -20.67 in-none in 8.817 Saltbr-none 999.0 HRD-in -72.59, -45.63 71.09, -1.3 none-in-out SNCnio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioi APE10-dihe-na -136.56, 156.53 APE9-dihe-na 140.45, 169.15 APE8-dihe-in -83.59, 130.49 APE8-rot-none 999.0 APE67-dihe-in -60.96, -19.48 -69.78, -35.01 APE12-dist-in 12.005 APE11-dist-in 11.47 APE10-dist-out 8.113 APE9-dist-in 5.608 None SEP729 SEP729 EM 6.8 999.0 999.0 A 805 285 4 0 0 0 [[457, 716]] 1.0 6q0k Homo sapiens TKL_BRAF_HUMAN TKL 1.4e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 6Q0KB P15056 449 733 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None -125.68, -157.33 46.68, 85.75 -103.02, 25.67 999.0, 999.0 -59.95, -20.61 in-none in 8.816 Saltbr-none 999.0 HRD-in -72.72, -45.54 70.99, -1.15 none-in-out SNCnio in-out ActLoopNT-in 2.863 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iioi APE10-dihe-na -136.64, 156.57 APE9-dihe-na 140.44, 169.17 APE8-dihe-in -83.6, 130.41 APE8-rot-none 999.0 APE67-dihe-in -60.93, -19.46 -69.77, -35.05 APE12-dist-in 12.006 APE11-dist-in 11.471 APE10-dist-out 8.112 APE9-dist-in 5.609 None SEP729 SEP729 EM 6.8 999.0 999.0 B 805 281 4 0 0 0 [[457, 716]] 1.0 6q0k Homo sapiens TKL_BRAF_HUMAN TKL 1.4e-80 277.0 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 8VYVC P15056 362 733 766.0 No_ligand No_ligand Inactive None 999.0 999.0 None 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-none in 8.58 Saltbr-none 999.0 HRD-in -70.11, -50.02 76.69, -10.1 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 142.8 APE8-rot-none 999.0 APE67-dihe-in -62.43, -28.28 -57.02, -49.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K601E SEP365,SEP729 SEP365,SEP729 EM 5.86 999.0 999.0 C 767 178 92 0 0 24 [[457, 716]] 1.0 8vyv Homo sapiens TKL_BRAF_HUMAN TKL 2.4e-80 276.1 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
BRAF_HUMAN 4MNFA P15056 449 720 766.0 29L:801 Type1 None DFGin 6.831 14.084 BLAminus -138.14, -173.65 64.87, 78.28 -102.21, 29.93 290.33, 73.26 -66.38, -51.46 in-in in 8.582 Saltbr-in 2.768 HRD-in -70.14, -50.01 76.68, -10.07 in-in-none SNCiin in-none ActLoopNT-in 2.834 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 142.76 APE8-rot-in 296.87 APE67-dihe-in -62.48, -28.21 -57.0, -49.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 V600E None None XRAY 2.802 0.215 0.275 A 329 257 15 0 0 15 [[457, 716]] 1.0 4mnf Homo sapiens TKL_BRAF_HUMAN TKL 1.4e-81 279.9 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf

TKL_BRAF (Serine/threonine-protein kinase B-raf)

Total number of chains: 0
Active chains: 0
Family: TKL
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name