PDB: 4MNE — 2 kinases

Total number of chains: 8
Active chains: 2
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 50.0% 4MNEB
DFGin BLBplus 4 50.0% 4MNEA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
STE MAP2K1 MP2K1_HUMAN 4MNEA 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type1 63 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNED 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type1 66 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNEE 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type3 62 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4MNEH 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ACP, 573, 573 ATPlike, Type3, Allosteric 66 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1
TKL BRAF BRAF_HUMAN 4MNEB 2.848 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioi No_ligand No_ligand 449 - 722 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4MNEC 2.848 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 449 - 720 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4MNEF 2.848 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 449 - 721 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4MNEG 2.848 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioi No_ligand No_ligand 449 - 720 0 None None Serine/threonine-protein kinase B-raf

PDB: 4MNE — 2 kinases

Total number of chains: 8
Active chains: 2
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 50.0% 4MNEB
DFGin BLBplus 4 50.0% 4MNEA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
STE MAP2K1 MP2K1_HUMAN 4MNEA 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type1 63 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4MNED 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type1 66 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4MNEE 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ACP, 573 ATPlike, Type3 62 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4MNEH 2.848 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ACP, 573, 573 ATPlike, Type3, Allosteric 66 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
TKL BRAF BRAF_HUMAN 4MNEB 2.848 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioi No_ligand No_ligand 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 4MNEC 2.848 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 449 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 4MNEF 2.848 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 4MNEG 2.848 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioi No_ligand No_ligand 449 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens

PDB: 4MNE — 2 kinases

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism