8VYS

BRAF (Serine/threonine-protein kinase B-raf)
Group: TKL
Uniprot: BRAF_HUMAN
Organism: Homo sapiens
Domain boundary: 457 - 716
Resolu: 3.06

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAplus out-out out-out A1AEN Type1.5_Back 235 - 738 13
Representative sequence - Chain A
9 19 29 39
gmaalsgggg ggaepgqalf ngdmepeaga gagaaassaa
49 59 69 79
dpaipeevwn ikqmikltqe hiealldkfg gehnppsiyl
89 99 109 119
eayeeytskl dalqqreqql leslgngtdf svsssasmdt
129 139 149 159
vtssssssls vlpsslsvfq nptdvarsnp kspqkpivrv
169 179 189 199
flpnkqrtvv parcgvtvrd slkkalmmrg lipeccavyr
209 219 229 239
iqdgekkpig wdtdiswltg eelhvevlen vplttHNFVR
249 259 269 279
KTFFTLAFCD FCRKLLFQGF RCQTCGYKFH QRCSTEVPLM
289 299 309 319
CVnydqldll fvskffehhp ipqeeaslae taltsgssps
329 339 349 359
apasdsigpq iltspspsks ipipqpfrpa dedhrnqfgq
369 379 389 399
RDRSSSAPNV Hintiepvni ddlirdqgfr gdggsttgls
409 419 429 439
atppaslpgs ltnvkalqks pgpqrerkss sssedrnrmk
449 459 469 479
tlgrrdssDD WEIPDGQITV GQRIGSGSFG TVYKGKWHGD
489 499 509 519
VAVKMLNVTA PTPQQLQAFK NEVGVLRKTR HVNILLFMGY
529 539 549 559
STKPQLAIVT QWCEGSSLYH HLHIIETKFE MKKLIDIARQ
569 579 589 599
TAQGMDYLHA KSIIHRDLKS NNIFLHEDLT VKIGDFGLAT
609 619 629 639
EKsrwsgshq feqlsGSILW MAPEVirmqd knPYSFQSDV
649 659 669 679
YAFGIVLYEL MTGQLPYsni nnrdqiifmv grgylSPDLS
689 699 709 719
KVRSNCPKAM KRLMAECLKK KRDERPLFPQ ILASIELLAR
729 739 749 759
SLPKIHRSAS EPSLNRAGFq tedfslyaca spktpiqagg

ygafpvh
Lower-case residues are disordered in structure.
Mutations: V600E
Phosphorylation: X365,X729